The article analyzes clinical manifestations, operative diagnostics and emergency medical care for endocrine emergencies. The authors notes that urgent endocrine conditions are serious and potentially life-threatening conditions that require immediate medical attention. Medical care in such cases may include rapid diagnosis and immediate treatment to prevent complications. Medical care for urgent endocrine conditions is critically important for saving the patient’s life and preventing serious complications. One of the directions of improving the methods of medical care for urgent endocrine conditions is the use of the latest technologies and innovative methods of treatment.
{"title":"Endocrine emergencies: clinical manifestations, operative diagnostics and emergency medical care","authors":"E.R. Karpenko, I.D. Gurova, A.E. Pogodina, A.N. Kompaniets, V.E. Bairova, D.A. Zaichuk, A.A. Egorova","doi":"10.18137/cardiometry.2023.27.150160","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.150160","url":null,"abstract":"The article analyzes clinical manifestations, operative diagnostics and emergency medical care for endocrine emergencies. The authors notes that urgent endocrine conditions are serious and potentially life-threatening conditions that require immediate medical attention. Medical care in such cases may include rapid diagnosis and immediate treatment to prevent complications. Medical care for urgent endocrine conditions is critically important for saving the patient’s life and preventing serious complications. One of the directions of improving the methods of medical care for urgent endocrine conditions is the use of the latest technologies and innovative methods of treatment.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46440232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.8695
I.K. Nakhusheva, D. Yurchenko, M.M. Sviridova, N.K. Dzhgarkava, M. V. Yarosh, Y.E. Emets
The COVID-19 infection has become an unexpected challenge for global health in recent years. The SARS-CoV-2 virus, which causes severe illness in adults, was most often asymptomatic in the pediatric population. However, since the appearance of the new virus, the estimated share of infected children has risen from less than 2% to 8.5% of all infected patients. Taking into account the fact that asymptomatic and oligosymptomatic pediatric patients most often do not complain, it can be assumed that the exact occurrence rate of the SARS-CoV-2 virus among children is higher than officially published data. Similarly to adults, the presence of comorbidities in children was associated with severe forms of the coronavirus infection and the need for intensive care. The clinical pattern of COVID-19 in children is not fundamentally different from that in adult patients, but however, gastrointestinal symptoms are found much more often. In addition, complications characteristic of the pediatric population are observed. The aim hereof was to analyze the features of the manifestation of the COVID-19 infection in pediatric patients.
{"title":"Features of the course of Covid-19 infection in children","authors":"I.K. Nakhusheva, D. Yurchenko, M.M. Sviridova, N.K. Dzhgarkava, M. V. Yarosh, Y.E. Emets","doi":"10.18137/cardiometry.2023.27.8695","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.8695","url":null,"abstract":"The COVID-19 infection has become an unexpected challenge for global health in recent years. The SARS-CoV-2 virus, which causes severe illness in adults, was most often asymptomatic in the pediatric population. However, since the appearance of the new virus, the estimated share of infected children has risen from less than 2% to 8.5% of all infected patients. Taking into account the fact that asymptomatic and oligosymptomatic pediatric patients most often do not complain, it can be assumed that the exact occurrence rate of the SARS-CoV-2 virus among children is higher than officially published data. Similarly to adults, the presence of comorbidities in children was associated with severe forms of the coronavirus infection and the need for intensive care. The clinical pattern of COVID-19 in children is not fundamentally different from that in adult patients, but however, gastrointestinal symptoms are found much more often. In addition, complications characteristic of the pediatric population are observed. The aim hereof was to analyze the features of the manifestation of the COVID-19 infection in pediatric patients.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47532994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.221228
K.A. Sytdykova, Y. V. Kazantseva, A. Sinanyan, M.N. Dulkina, G.O. Fatenkov, M.A. Fatenkova
This article analyzes age-related risk factors that affect the population health. Risk factors that contribute to poor health are those that increase the likelihood of getting sick or injured. Risk factors are often presented individually, but it is confirmed that they are often interrelated in practice. For example, physical inactivity will lead to weight gain, high blood pressure, and high cholesterol over time. Together, they significantly increase the chance of developing chronic heart and other diseases, and the older a person is, the more various factors impact his health. The study aims to identify age-related risk factors affecting the morbidity of the population. The research was carried out using theoretical methods: the study of scientific articles, literature on the topic, and practical methods: observation and generalization. As a result, it was revealed what risk factors affect the population’s morbidity, the form and degree of their influence on humans, and methods for reducing the influence of these factors were proposed.
{"title":"Age-related risk factors affecting the population morbidity","authors":"K.A. Sytdykova, Y. V. Kazantseva, A. Sinanyan, M.N. Dulkina, G.O. Fatenkov, M.A. Fatenkova","doi":"10.18137/cardiometry.2023.27.221228","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.221228","url":null,"abstract":"This article analyzes age-related risk factors that affect the population health. Risk factors that contribute to poor health are those that increase the likelihood of getting sick or injured. Risk factors are often presented individually, but it is confirmed that they are often interrelated in practice. For example, physical inactivity will lead to weight gain, high blood pressure, and high cholesterol over time. Together, they significantly increase the chance of developing chronic heart and other diseases, and the older a person is, the more various factors impact his health. The study aims to identify age-related risk factors affecting the morbidity of the population. The research was carried out using theoretical methods: the study of scientific articles, literature on the topic, and practical methods: observation and generalization. As a result, it was revealed what risk factors affect the population’s morbidity, the form and degree of their influence on humans, and methods for reducing the influence of these factors were proposed.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44660353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27/161163
V. Kureichik, S. S. Pirozhkov, O. N. Sakharova, K. V. Kamyshev, Elena N. Kamenskaya
At present, in the conditions of the active development of the information society, when information is the main means of production, special attention is paid to the methods and means of organizing its protection and storage. A large number of developments, both software and physical, are devoted to this issue. Cybersecurity is becoming more and more necessary every day and, as a result, popular, as a result of which a large number of specialists with a basic education in the field of information security graduate every year. In addition, an extensive regulatory framework has been developed that regulates the procedure and principles for protecting and storing data. Thus, we can talk about the existence of an entire industry aimed at maintaining and improving information security. Besides, it is proved herein that there is a need to develop a method for quantitative assessment of the security of stored data.
{"title":"Analysis of methods for assessing threats in the field of data storage","authors":"V. Kureichik, S. S. Pirozhkov, O. N. Sakharova, K. V. Kamyshev, Elena N. Kamenskaya","doi":"10.18137/cardiometry.2023.27/161163","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27/161163","url":null,"abstract":"At present, in the conditions of the active development of the information society, when information is the main means of production, special attention is paid to the methods and means of organizing its protection and storage. A large number of developments, both software and physical, are devoted to this issue. Cybersecurity is becoming more and more necessary every day and, as a result, popular, as a result of which a large number of specialists with a basic education in the field of information security graduate every year. In addition, an extensive regulatory framework has been developed that regulates the procedure and principles for protecting and storing data. Thus, we can talk about the existence of an entire industry aimed at maintaining and improving information security. Besides, it is proved herein that there is a need to develop a method for quantitative assessment of the security of stored data.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41951170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.181193
Hussam Abed, A. Abdelaziz
Aim. The neuromuscular blocker has long been used during surgical procedures. The neuromuscular blockade produced by rocuronium can be reversed with sugammadex and neostigmine as reversal agents. This systematic review aims to determine the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Materials and Methods. This review examined recent studies assessing the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Data were searched from Google Scholar, PubMed, Hindawi, Anesthesiology, MEDLINE, and CENTRAL using keywords’ General Anesthesia,’ ‘Reversal Agent,’ ‘Rocuronium for Pediatric Patients,’ ‘Neuromuscular Blockers,’ ‘Sugammadex and Neostigmine,’ ‘Role of Analgesics.’ The review followed PRISMA guidelines. Results. The initial search for publications comparing sugammadex and neostigmine as a reversal agent of rocuronium for pediatric patients yielded 9000 papers, from which 600 were selected. The reviews’ articles were further analyzed to ensure they were pertinent to the Comparative Impact of Reversal Agents (Sugammadex And Neostigmine) of Rocuronium for Pediatric Patients. Around 319 references were examined for their potential applicability to the medical field of anesthesia. A total of 15 articles were included, with preference given to those published from 2014 to 2023 during the last ten years. Conclusion. The particular relaxant-binding medication promptly and successfully alleviates rocuronium-induced neuromuscular blockade in pediatric surgery patients. Considering the study’s outcomes, it can be concluded that sugammadex may restore any level of steroidal muscle relaxant-induced neuromuscular block faster than neostigmine.
{"title":"Comparative study between sugammedex and neostigmine as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anaesthesia","authors":"Hussam Abed, A. Abdelaziz","doi":"10.18137/cardiometry.2023.27.181193","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.181193","url":null,"abstract":"Aim. The neuromuscular blocker has long been used during surgical procedures. The neuromuscular blockade produced by rocuronium can be reversed with sugammadex and neostigmine as reversal agents. This systematic review aims to determine the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Materials and Methods. This review examined recent studies assessing the impact of sugammadex and neostigmine comparison as a reversal agent of rocuronium for pediatric patients 2-12 years old going for surgery under general anesthesia. Data were searched from Google Scholar, PubMed, Hindawi, Anesthesiology, MEDLINE, and CENTRAL using keywords’ General Anesthesia,’ ‘Reversal Agent,’ ‘Rocuronium for Pediatric Patients,’ ‘Neuromuscular Blockers,’ ‘Sugammadex and Neostigmine,’ ‘Role of Analgesics.’ The review followed PRISMA guidelines. Results. The initial search for publications comparing sugammadex and neostigmine as a reversal agent of rocuronium for pediatric patients yielded 9000 papers, from which 600 were selected. The reviews’ articles were further analyzed to ensure they were pertinent to the Comparative Impact of Reversal Agents (Sugammadex And Neostigmine) of Rocuronium for Pediatric Patients. Around 319 references were examined for their potential applicability to the medical field of anesthesia. A total of 15 articles were included, with preference given to those published from 2014 to 2023 during the last ten years. Conclusion. The particular relaxant-binding medication promptly and successfully alleviates rocuronium-induced neuromuscular blockade in pediatric surgery patients. Considering the study’s outcomes, it can be concluded that sugammadex may restore any level of steroidal muscle relaxant-induced neuromuscular block faster than neostigmine.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43620065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.111117
Elvira R. Safiullina, Ekaterina I. Rychkova, V. Irina, ayorova, Diana Kh. Khairutdinova, Anna A. Slonskaya, Anna S. Faronova, Yaroslava A. Davydova, Izobella A. Mussova
The article analyzes the use of digital methods and artificial intelligence capabilities for diagnostics in the field of obstetrics and gynecology. The author notes that digital methods and artificial intelligence (AI) have a high potential for the diagnosis of gynecological diseases, since it can analyze medical images and other medical data with great accuracy and speed. For example, AI can help in the diagnosis of cervical cancer by identifying anomalies in digital images and screening tests. The use of AI can also help in the recognition of other gynecological diseases, such as endometriosis, uterine fibroids, polyps, etc. In addition, AI can help improve the efficiency and accuracy of diagnostics, as well as reduce the time required to process medical data. This can be especially important in cases where diagnosis needs to be done quickly in order to start treatment as early as possible. However, it should be noted that AI cannot completely replace the experience and expertise of doctors. Still, it can help doctors make more accurate diagnoses and develop more effective treatment strategies.
{"title":"Application of digital methods and artificial intelligence capabilities for diagnostics in obstetrics and gynecology","authors":"Elvira R. Safiullina, Ekaterina I. Rychkova, V. Irina, ayorova, Diana Kh. Khairutdinova, Anna A. Slonskaya, Anna S. Faronova, Yaroslava A. Davydova, Izobella A. Mussova","doi":"10.18137/cardiometry.2023.27.111117","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.111117","url":null,"abstract":"The article analyzes the use of digital methods and artificial intelligence capabilities for diagnostics in the field of obstetrics and gynecology. The author notes that digital methods and artificial intelligence (AI) have a high potential for the diagnosis of gynecological diseases, since it can analyze medical images and other medical data with great accuracy and speed. For example, AI can help in the diagnosis of cervical cancer by identifying anomalies in digital images and screening tests. The use of AI can also help in the recognition of other gynecological diseases, such as endometriosis, uterine fibroids, polyps, etc. In addition, AI can help improve the efficiency and accuracy of diagnostics, as well as reduce the time required to process medical data. This can be especially important in cases where diagnosis needs to be done quickly in order to start treatment as early as possible. However, it should be noted that AI cannot completely replace the experience and expertise of doctors. Still, it can help doctors make more accurate diagnoses and develop more effective treatment strategies.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48969145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.2632
O. Kit, E. Frantsiyants, V. Bandovkina, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, D. Cheryarina, Y. Pogorelova, L. K. Trepitaki, I. Kotieva, L. Rozenko, Marina A. Arzamastseva, E. Agarkova, M. Sergeeva, V. Irina, Neskubina, K. Lidia, Trepitaki, A. Marina, Arzamastseva
The aim was to study changes in the functioning of the hypothalamic-pituitary-gonadal (HPG) axis in BALB/c Nude mice of both sexes with multiple primary malignant tumors (MPMTs). The BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14), a reference group of mice of both sexes with standard subcutaneous inoculation of B16/F10 melanoma (n=14); the main group of mice with the reproduction of the MPMT model (n=14); B16/ F10 melanoma and Lewis carcinoma were inoculated into mice sequentially subcutaneously on two sides: one on the left side and the other on the right side. After 15 days of the growth of the malignant tumors, GnRH, LH and FSH contents were determined by ELISA using standard kits in 1% of the homogenates of the hypothalamic and pituitary tissues, and estradiol content (E2) was determined in 10% homogenates of ovaries and testes, as well concentrations of testosterone (T) and progesterone (P4) were identified in blood serum with the standard RIA kits (Immunotech, Czech Republic). Results. In the hypothalamus in females of the reference and main groups, the level of GnRH increased by 2.5-4 times, and in males it decreased by an average of 3.1 times; in response to those changes in animals of both sexes in the reference group and in the main group only in females in the pituitary gland the level of LH increased by 1.3-1.6 times, however a decrease in FSH in all groups was more pronounced in females: by 7.8-13.7 times and less pronounced in males: by 1.4-1.7 times (р˂0, 05). In the gonads of females, the level of E2 increased, but the levels of T and P4 decreased, while P4 increased in males. Blood parameters did not reflect hormonal changes in the organs. Conclusion. Abnormalities in the HHG axis performance, along with primary immunodeficiency, play a decisive role in overcoming antitumor protection for uncharacteristic malignant tumors.
{"title":"Effect made by the growth of multiple primary malignant tumors on the hypothalamicpituitary-gonadal axis in BALB/c Nude mice of both sexes","authors":"O. Kit, E. Frantsiyants, V. Bandovkina, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, D. Cheryarina, Y. Pogorelova, L. K. Trepitaki, I. Kotieva, L. Rozenko, Marina A. Arzamastseva, E. Agarkova, M. Sergeeva, V. Irina, Neskubina, K. Lidia, Trepitaki, A. Marina, Arzamastseva","doi":"10.18137/cardiometry.2023.27.2632","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.2632","url":null,"abstract":"The aim was to study changes in the functioning of the hypothalamic-pituitary-gonadal (HPG) axis in BALB/c Nude mice of both sexes with multiple primary malignant tumors (MPMTs). The BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14), a reference group of mice of both sexes with standard subcutaneous inoculation of B16/F10 melanoma (n=14); the main group of mice with the reproduction of the MPMT model (n=14); B16/ F10 melanoma and Lewis carcinoma were inoculated into mice sequentially subcutaneously on two sides: one on the left side and the other on the right side. After 15 days of the growth of the malignant tumors, GnRH, LH and FSH contents were determined by ELISA using standard kits in 1% of the homogenates of the hypothalamic and pituitary tissues, and estradiol content (E2) was determined in 10% homogenates of ovaries and testes, as well concentrations of testosterone (T) and progesterone (P4) were identified in blood serum with the standard RIA kits (Immunotech, Czech Republic). Results. In the hypothalamus in females of the reference and main groups, the level of GnRH increased by 2.5-4 times, and in males it decreased by an average of 3.1 times; in response to those changes in animals of both sexes in the reference group and in the main group only in females in the pituitary gland the level of LH increased by 1.3-1.6 times, however a decrease in FSH in all groups was more pronounced in females: by 7.8-13.7 times and less pronounced in males: by 1.4-1.7 times (р˂0, 05). In the gonads of females, the level of E2 increased, but the levels of T and P4 decreased, while P4 increased in males. Blood parameters did not reflect hormonal changes in the organs. Conclusion. Abnormalities in the HHG axis performance, along with primary immunodeficiency, play a decisive role in overcoming antitumor protection for uncharacteristic malignant tumors.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41297464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.6374
O. Bocharova, Ilia V. Kazeev, V. E. Shevchenko, N. Ionov, O. P. Sheichenko, E. Bocharov, Regina V. Karpova, V. Kucheryanu, A. Lagunin, D. Filimonov, Vyacheslav B. Kosorukov, V. Poroikov, V. Tutelyan, N. V. Pyatigorskaya, A. Victor, Tutelyan
The original herbal formula of homeostasis regulator Multiphytoadaptogen (MPhA) for preventive oncology developed by the N.N. Blokhin Center of Oncology containing phytocomponents from Schizandra chinensis has been investigated in vitro, in vivo and in clinical studies. The MPhA multi-target effects are achieved by optimizing the functioning of the nervous, immune and endocrine defense systems that regulate homeostasis under stress. Everything that has been previously studied for MPhA can be considered as preclinical testing, including clinical research, which can be regarded as the pilot studies. This was allowed because MPhA in Russia is registered as a parapharmaceutical agent and therefore standardized according to established requirements. However, due to the high efficiency of MPhA, a detailed study of the chemical composition and standardization of it is required, including the composition of Schisandra chinensis Baill (Schisandraceae) active components, which turned out to be translocated into MPhA as a result of the extraction technology developed. So, for MPhA identification and standardization we detected the secondary metabolites in the herbal formula MPhA as well as in fruits extract of Schisándra chinénsis using high-performance liquid chromatography in combination with mass spectrometry. Chromatography was performed on an ACQUITY UPLC BEH C18 column in a gradient mode. A TSQ Vantage triple quadrupole mass spectrometer with electrospray ionization was used. Lignans Schizandrin and Schizantherin A were identified in the MPhA as well as in Schisándra chinénsis fruits extract obtained by the technology developed. The determined secondary metabolites can be used for standardization and quality testing of the herbal formula MPhA. In addition, we performed in silico analyzes of Schizandrin and Schizantherin A biological activity spectra using computer program PASS (Prediction of Activity Spectra for Substances). Schizandrin and Schizantherin A activities, according the scientific literature and in silico analysis, correspond to the properties studied for MPhA which therefore fits into the concept of a drug – homeostasis regulator adaptogen for preventive oncology.
{"title":"Secondary metabolites of Schisandra chinensis in homeostasis regulator adaptogen herbal formula for preventive oncology","authors":"O. Bocharova, Ilia V. Kazeev, V. E. Shevchenko, N. Ionov, O. P. Sheichenko, E. Bocharov, Regina V. Karpova, V. Kucheryanu, A. Lagunin, D. Filimonov, Vyacheslav B. Kosorukov, V. Poroikov, V. Tutelyan, N. V. Pyatigorskaya, A. Victor, Tutelyan","doi":"10.18137/cardiometry.2023.27.6374","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.6374","url":null,"abstract":"The original herbal formula of homeostasis regulator Multiphytoadaptogen (MPhA) for preventive oncology developed by the N.N. Blokhin Center of Oncology containing phytocomponents from Schizandra chinensis has been investigated in vitro, in vivo and in clinical studies. The MPhA multi-target effects are achieved by optimizing the functioning of the nervous, immune and endocrine defense systems that regulate homeostasis under stress. Everything that has been previously studied for MPhA can be considered as preclinical testing, including clinical research, which can be regarded as the pilot studies. This was allowed because MPhA in Russia is registered as a parapharmaceutical agent and therefore standardized according to established requirements. However, due to the high efficiency of MPhA, a detailed study of the chemical composition and standardization of it is required, including the composition of Schisandra chinensis Baill (Schisandraceae) active components, which turned out to be translocated into MPhA as a result of the extraction technology developed. So, for MPhA identification and standardization we detected the secondary metabolites in the herbal formula MPhA as well as in fruits extract of Schisándra chinénsis using high-performance liquid chromatography in combination with mass spectrometry. Chromatography was performed on an ACQUITY UPLC BEH C18 column in a gradient mode. A TSQ Vantage triple quadrupole mass spectrometer with electrospray ionization was used. Lignans Schizandrin and Schizantherin A were identified in the MPhA as well as in Schisándra chinénsis fruits extract obtained by the technology developed. The determined secondary metabolites can be used for standardization and quality testing of the herbal formula MPhA. In addition, we performed in silico analyzes of Schizandrin and Schizantherin A biological activity spectra using computer program PASS (Prediction of Activity Spectra for Substances). Schizandrin and Schizantherin A activities, according the scientific literature and in silico analysis, correspond to the properties studied for MPhA which therefore fits into the concept of a drug – homeostasis regulator adaptogen for preventive oncology.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49563330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.194199
A. P. Reddy, R. Sunitha, P. Thangavel, J. Ramkumar, S. Miller
Cardiopulmonary bypass (CPB) might have several systemic impacts on organs such as the liver. This prospective research was designed to investigate the occurrence & significance of this shift in more depth.40 patients of cardiopulmonary bypass were chosen at random for the research. After coronary artery bypass grafting, total bilirubin, direct bilirubin, Alkaline Phosphatase (ALP), SGOT, & SGPT were determined preoperatively & post operation after 24, 48 hours. The liver function tests’ (LFT) post-operative value, in relation to above factors, was compared with preoperative value using t test. The results show a statistically significant increase (p ≤ 0.05) in total bilirubin, direct bilirubin, Alkaline Phosphatase, SGOT, & SGPT on post-operative days 1 & 2 in patients who had complex surgeries & valve replacement surgeries while on CPB. Low cardiac output may be related with a transient rise in hepatic enzyme levels following surgery. Throughout the post-operative period, hepatic enzyme levels were higher in patients with longer CPB durations.
{"title":"Effects of cardiopulmonary bypass on liver function in patients undergoing cardiac surgery","authors":"A. P. Reddy, R. Sunitha, P. Thangavel, J. Ramkumar, S. Miller","doi":"10.18137/cardiometry.2023.27.194199","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.194199","url":null,"abstract":"Cardiopulmonary bypass (CPB) might have several systemic impacts on organs such as the liver. This prospective research was designed to investigate the occurrence & significance of this shift in more depth.40 patients of cardiopulmonary bypass were chosen at random for the research. After coronary artery bypass grafting, total bilirubin, direct bilirubin, Alkaline Phosphatase (ALP), SGOT, & SGPT were determined preoperatively & post operation after 24, 48 hours. The liver function tests’ (LFT) post-operative value, in relation to above factors, was compared with preoperative value using t test. The results show a statistically significant increase (p ≤ 0.05) in total bilirubin, direct bilirubin, Alkaline Phosphatase, SGOT, & SGPT on post-operative days 1 & 2 in patients who had complex surgeries & valve replacement surgeries while on CPB. Low cardiac output may be related with a transient rise in hepatic enzyme levels following surgery. Throughout the post-operative period, hepatic enzyme levels were higher in patients with longer CPB durations.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46422331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.233236
T. Onbysh, M. Vilkova, E.E. Dubovik, E. A. Nosov
The article deals with the interaction between the mother and the fetus in the aspect of immunology. The immunological problems which the maternal immune system may encounter in pregnancy and their potential negative effects on the fetal health are also of interest to us. Therefore, it is necessary to consider the features of the interaction between the fetus and the mother, which will allow assessing the prospects for future research in the field of the interaction between the maternal and fetal immune systems for more effective prevention and treatment of immunological problems in pregnancy.
{"title":"Interaction between the mother and the fetus in the aspect of immunology","authors":"T. Onbysh, M. Vilkova, E.E. Dubovik, E. A. Nosov","doi":"10.18137/cardiometry.2023.27.233236","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.233236","url":null,"abstract":"The article deals with the interaction between the mother and the fetus in the aspect of immunology. The immunological problems which the maternal immune system may encounter in pregnancy and their potential negative effects on the fetal health are also of interest to us. Therefore, it is necessary to consider the features of the interaction between the fetus and the mother, which will allow assessing the prospects for future research in the field of the interaction between the maternal and fetal immune systems for more effective prevention and treatment of immunological problems in pregnancy.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49283433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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