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Closed reduction of zygomatic arch fractures by using Tubbs-Logan mitral valve dilator Tubbs-Logan二尖瓣扩张器在颧弓骨折闭合复位中的应用
IF 0.1 Pub Date : 2020-04-25 DOI: 10.32448/entupdates.709516
Y. Yontar, Sedat Tatar, H. Baykan
Objective : To present technical details and experiences regarding the use of a Tubbs-Logan mitral valve dilator for the closed reduction of zygomatic arch fractures. Method: Over a period of about three years, closed reduction was indicated and performed in 22 patients with a zygomatic arch fracture. In all patients, depressed fracture segments were reduced using a Tubbs-Logan mitral valve dilator via the Gillies’ temporal approach. Results: The majority of the injuries were due to motor vehicle collisions (n=8, 36.4%). The zygomatic arch fracture was isolated in 12 patients (54.5%). However, it was a component of a zygomatic complex fracture in 10 patients (45.5%). Of those, rigid internal fixation of the zygomatic body was performed in 8 and the zygomatic body was only closely reduced by a bone hook in 2 patients. Repair of a concomitant orbital floor fracture was performed in 2, a mandibular angle fracture in 1 and a frontal sinus fracture in 1 patient. The reduction status of the zygomatic arch was excellent in 12 (54.5%), good in 8 (36.4%) and fair in 2 patients (9.1%). During the follow-ups, no functional or cosmetic sequelae regarding repaired fractures of the zygomatic arch, zygomatic body or other facial bones were recorded. Conclusion: We suggest that the Tubbs-Logan mitral valve dilator is a safe and effective alternative in terms of closed reduction of zygomatic arch fractures, whether they are isolated or not. We think that further ergonomic modifications would be beneficial to improve the positioning of the instrument in restricted areas observed due to severe depression of the zygomatic arch.
目的:介绍Tubbs-Logan二尖瓣扩张器用于颧弓骨折闭式复位术的技术细节和经验。方法:在三年多的时间里,对22例颧骨弓骨折患者进行了闭合复位。所有患者均采用Tubbs-Logan二尖瓣扩张器经Gillies颞部入路复位凹陷骨折节段。结果:以机动车碰撞伤害为主(n=8, 36.4%)。孤立性颧弓骨折12例(54.5%)。然而,在10例(45.5%)患者中,它是颧骨复合体骨折的一个组成部分。其中8例患者行颧体刚性内固定,2例患者行骨钩紧密复位。2例合并眶底骨折,1例下颌角骨折,1例额窦骨折。颧弓复位情况优良12例(54.5%),良好8例(36.4%),一般2例(9.1%)。随访期间,颧骨弓、颧骨体或其他面骨骨折修复后无功能性或美观性后遗症。结论:我们认为Tubbs-Logan二尖瓣扩张器是一种安全有效的颧弓骨折闭式复位术,无论是否孤立。我们认为进一步的人体工程学修改将有助于改善仪器在由于颧骨弓严重凹陷而观察到的受限区域的定位。
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引用次数: 0
Editorial 编辑
IF 0.1 Pub Date : 2020-04-25 DOI: 10.32448/entupdates.726222
Cemal Cingi
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引用次数: 0
The Effect of Selfies on Cosmetic Surgery 自拍对整容手术的影响
IF 0.1 Pub Date : 2020-04-20 DOI: 10.32448/entupdates.664150
Mohammed Alkarzae, B. Aldosari, Lama S Alalula, Reham Almuhaya, Ibrahim AlAwadh
Objective: Objectives: The present study aimed to evalu-ate how selfies (self-photographs) are related to cosmetic surgery. Methods: This is a prospective, observational study per-formed using a self-administered survey. An online ques-tionnaire was distributed through social media to a ran-dom sample of 653 individuals from Saudi Arabia aged 18 to 65 years (mean 29.4±10.9 years). 25.1% of respondents were male (164 men), 74.9% were female (489 women). Results: The majority of respondents were satisfied by their appearance in the selfie. 5.8% of respondents stated they had had a cosmetic procedure as a result of self-pho-tography. The procedures involved were: lip fillers, botox, rhinoplasty, cheek fillers, chin implant, scar revision and face-lift. A further 37.8% of respondents expressed a wish to undergo a cosmetic procedure (rhinoplasty, lip fillers, chin implant, scar revision, cheek fillers, botox or face-lift) due to selfies. 134 respondents expressed dissatisfac-tion with their appearance in selfies, 47 of whom (35.1%) expressed an interest in a cosmetic procedure. 46% of those who believed selfies reveal their deformities also wished to have a corrective procedure. Concerning their preferred type of procedure, women chose rhinoplasty, lip fillers, cheek fillers, anti-aging botox, face-lifts and chin implants more often than men. Conclusion: Improvements to body-image through cosmetic surgery outcomes should improve body image and thereby promote self-esteem and socialization. The selfie may underlie the increase in demand for cosmetic procedures and the number of such procedures subsequently undertaken.
目的:本研究旨在评估自拍(自拍照)与整容手术的关系。方法:这是一项前瞻性观察性研究,采用自我管理调查。通过社交媒体向来自沙特阿拉伯的653名年龄在18至65岁(平均29.4±10.9岁)的随机样本发放在线问卷。男性占25.1%(164人),女性占74.9%(489人)。结果:大多数受访者对自己在自拍中的形象感到满意。5.8%的受访者表示,他们曾因自拍而进行过整容手术。所涉及的手术包括:嘴唇填充、肉毒杆菌注射、鼻整形、面颊填充、下巴植入、疤痕修复和面部提升。另有37.8%的受访者表示希望因自拍而接受整容手术(隆鼻、丰唇、下巴植入、疤痕修复、面颊填充、肉毒杆菌注射或整容)。134名受访者对自己的自拍照不满意,其中47人(35.1%)表示有兴趣做整容手术。46%认为自拍会暴露自己的畸形的人也希望做矫正手术。至于她们喜欢的手术类型,女性比男性更多地选择隆鼻、丰唇、面颊填充、抗衰老肉毒杆菌、拉皮和下巴植入。结论:通过整形手术效果改善身体形象可以改善身体形象,从而促进自尊和社交。自拍可能是美容手术需求增加以及随后进行的此类手术数量增加的基础。
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引用次数: 5
A comprehensive study of oxidative stress in patients with chronic otitis media 慢性中耳炎患者氧化应激的综合研究
IF 0.1 Pub Date : 2020-04-15 DOI: 10.32448/ENTUPDATES.630369
M. Çelik, I. Koyuncu
Objective: The purpose of this research study was to evaluate dynamic thiol/disulphide homeostasis (TDH) as a novel oxidative stress marker in participants with noncholesteatomatous chronic otitis media (ncCOM) and cholesteatomatous chronic otitis media (cCOM), as well as to investigate lipid hydroperoxide (LOOH), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) markers and compare the results with a healthy control group. Methods: This research was carried out at Harran University Medical Faculty Ear-Nose-Throat Department, between April 2017 and April 2019. This was a prospective controlled trial study including 121 participants, 40 ncCOM, 39 cCOM and 42 healthy controls. Total thiol, native thiol, disulphide levels and LOOH, TAS, TOS levels were measured in plasma of all patients and healthy volunteers. Results: In our study, we found that total thiol, native thiol levels, native thiol/total thiol ratios and TAS levels were significantly lower in cCOM patients compared with the control group (p<0.01). Disulphide/native thiol, disulphide/total thiol ratios, LOOH, TOS and OSI levels were significantly increased in the cCOM group compared with the control group (p<0.01). Conclusion: Oxidative stress (OS) is believed to be one of the underlying reasons for COM pathogenesis. In this research, we analyzed dynamic TDH as a novel OS marker using a novel improved fully automatic colorimetric technique, along with other parameters. This study may shed light on understanding the underlying reasons for the pathogenesis of COM and identify potential targets for antioxidant drug treatment.
目的:本研究的目的是评估动态硫醇/二硫稳态(TDH)作为一种新的氧化应激标志物在非胆固醇瘤性慢性中耳炎(ncCOM)和胆固醇瘤性慢性中耳炎(cCOM)参与者中,以及研究脂质过氧化氢(LOOH)、总抗氧化状态(TAS)、总氧化状态(TOS)和氧化应激指数(OSI)标志物,并将结果与健康对照组进行比较。方法:本研究于2017年4月至2019年4月在哈兰大学医学院耳鼻喉科进行。这是一项前瞻性对照试验研究,包括121名参与者,40名ncCOM, 39名cCOM和42名健康对照。测定所有患者及健康志愿者血浆中总硫醇、天然硫醇、二硫化物水平及LOOH、TAS、TOS水平。结果:我们的研究发现,cCOM患者的总硫醇、天然硫醇水平、天然硫醇/总硫醇比值和TAS水平均显著低于对照组(p<0.01)。与对照组相比,cCOM组二硫/天然硫醇、二硫/总硫醇比值、LOOH、TOS和OSI水平均显著升高(p<0.01)。结论:氧化应激(OS)可能是COM发病的潜在原因之一。在这项研究中,我们使用一种新的改进的全自动比色技术,以及其他参数,分析了动态TDH作为一种新的OS标记物。这项研究可能有助于理解COM发病机制的潜在原因,并确定抗氧化药物治疗的潜在靶点。
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引用次数: 1
A great mimicker of mastoiditis- Multisystem Langerhans’ cell histiocytosis 乳腺炎的伟大模仿者——多系统郎格汉斯细胞组织细胞增多症
IF 0.1 Pub Date : 2020-04-15 DOI: 10.32448/ENTUPDATES.673014
F. Kin, O. Ai, F. Hussain, B. Goh
Langerhans’ cell histiocytosis (LCH) is a rare group of diseases characterized by abnormal clonal proliferation of Langerhans cells in one or more systems. LCH can occur in any system. We report a case of bilateral otologic LCH that presented as a case of mastoiditis. Despite multiple courses of antibiotics, there was no improvement. Subsequent excision biopsy of a postauricular mass confirmed the diagnosis of LCH. The patient responded well to chemotherapy.
朗格汉斯细胞组织细胞增多症(LCH)是一组罕见的疾病,其特征是朗格汉斯细胞在一个或多个系统中异常克隆增殖。LCH可以发生在任何系统中。我们报告一例双侧耳科LCH,表现为乳突炎。尽管使用了多个疗程的抗生素,但没有任何改善。随后耳后肿块的切除活组织检查证实了LCH的诊断。病人对化疗反应良好。
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引用次数: 2
Retrospective analysis of ranula patients managed with surgical treatment ranula患者手术治疗的回顾性分析
IF 0.1 Pub Date : 2020-04-15 DOI: 10.32448/entupdates.688446
F. Altin, Y. Alimoglu
Objective: We aimed to examine patient characteristics, recurrence rate and efficacy of treatment methods in patients who underwent surgery with the diagnosis of ranula in our department retrospectively. The subject is discussed in the light of current literature. Methods: Twenty-seven patients with ranula managed surgically between 2008 and 2018 were included in this study. The indications, age and sex distribution, surgical pathology reports, surgical methods, complications encountered and recurrence rates were examined retrospectively. Results: The mean age was 27.48±18.66 years. There were 8 (29.6%) male and 19 (70.4%) female cases. The mean size of the ranula was 3.07±0.35 cm. When the symptoms were evaluated, 23 (85.2%) of the patients had a swelling in the floor of the mouth, 3 (11.1%) had a neck swelling and 1 (3.7%) had swelling on the lower surface of the tongue. The treatment method was marsupialization in 11 (40.7%) patients and ranula cyst excision in 16 (59.3%) patients. Four (14.8%) of these patients had a recurrence. The first surgical procedure was marsupialization in 3 (75%) and cyst excision in 1 (25%) of the cases with recurrence. Of the patients with recurrence, 3 subsequently underwent cyst excision and 1 of the patients underwent marsupialization. No complication or additional recurrence was observed in the follow-up of these patients. Conclusions: Concerning our ten years of experience with the management of ranula, we can conclude that ranula can be treated by both marsupialization and cyst excision with a low risk of recurrence.
目的:回顾性分析我科诊断为ranula的手术患者的特点、复发率和治疗方法的疗效。这个问题是根据目前的文献讨论的。方法:本研究纳入了2008年至2018年间手术治疗的27例ranula患者。回顾性分析适应症、年龄和性别分布、手术病理报告、手术方法、并发症和复发率。结果:平均年龄27.48±18.66岁。男性8例(29.6%),女性19例(70.4%)。ranula的平均大小为3.07±0.35厘米。在评估症状时,23名(85.2%)患者口腔底部肿胀,3名(11.1%)患者颈部肿胀,1名(3.7%)患者舌头下表面肿胀。治疗方法有袋化11例(40.7%),ranula囊肿切除16例(59.3%)。其中4例(14.8%)复发。在复发的病例中,第一次手术是3例(75%)的有袋切除术和1例(25%)的囊肿切除术。在复发的患者中,3名随后接受了囊肿切除术,1名患者接受了有袋化术。在这些患者的随访中没有观察到并发症或额外的复发。结论:根据我们十年来治疗ranula的经验,我们可以得出结论,ranula可以通过有袋切除术和囊肿切除术进行治疗,复发风险很低。
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引用次数: 0
A comparison of endoscopic and microscopic techniques for the repair of tympanic membrane perforations 内窥镜与显微技术在鼓膜穿孔修复中的比较
IF 0.1 Pub Date : 2019-12-20 DOI: 10.32448/ENTUPDATES.576183
İ. Güler, Müge Özcan
Objective: This study aims to compare endoscopic and microscopic tympanoplasty in terms of graft success rate and hearing gain. Methods: Medical records of 236 patients (99 females and 137 males) aged 18 to 74 years with chronic otitis media who underwent myringoplasty, between January 2014 and June 2017 were retrospectively compared. Patients were divided into two groups; microscopic myringoplasty (140 patients), endoscopic myringoplasty (96 patients). Demographic data, pure tone audiometric results preoperatively and 6 months postopera­tively, operation time, hearing gain and graft success rate were evaluated. Results: The mean operation time was 57.8±9.6 minutes for the endoscopic group and 78.6±17.7 minutes for the microscopic group (p<0.001). The mean preoperative air bone gap (ABG) was 24.1±11.5 dB for the microscopic group and 22.7±9.2 dB for the endoscopic group, whereas the mean postoperative ABG was 11.6±9.9 and 9.8±9.3 dB respectively. Graft success rate was 90.3% (213 patients) for entire group, 89.7% (131 patients) for the microscopic group, and 91.1% (82 patients) for the endoscopic group (p=0.727). The functional success rate (ABG ≤ 10 dB) was 72.5% (171 patients) in the entire group. The mean hearing gain was 12.4±10.8 and 12.8±9 dB in the microscopic and endoscopic groups respectively. Conclusion: Endoscopic technique offers similar graft success and hearing outcomes to microscopic technique along with a shorter operation time.
目的:本研究旨在比较内镜下和显微镜下鼓室成形术在移植物成功率和听力增益方面的差异。方法:回顾性比较2014年1月至2017年6月期间236名年龄在18至74岁之间接受鼓膜成形术的慢性中耳炎患者(99名女性和137名男性)的医疗记录。将患者分为两组;显微镜下鼓膜成形术(140例)、内镜下鼓膜成形法(96例)。评估人口统计学数据、术前和术后6个月纯音听力测量结果、手术时间、听力增益和移植物成功率。结果:内镜组和显微镜组的平均手术时间分别为57.8±9.6分钟和78.6±17.7分钟(p<0.001)。显微镜组和内镜组的平均术前空气骨间隙(ABG)分别为24.1±11.5 dB和22.7±9.2 dB,而术后平均ABG分别为11.6±9.9和9.8±9.3 dB。全组移植物成功率为90.3%(213例),显微镜组为89.7%(131例),内镜组为91.1%(82例)(p=0.727)。全组功能成功率(ABG≤10dB)为72.5%(171例)。显微镜组和内窥镜组的平均听力增益分别为12.4±10.8和12.8±9dB。结论:内窥镜技术提供了与显微镜技术相似的移植物成功率和听力结果,并且手术时间更短。
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引用次数: 1
Balance disorders and hypothyroidism: A rare cause worth remembering 平衡障碍和甲状腺功能减退:一个值得记住的罕见原因
IF 0.1 Pub Date : 2019-12-20 DOI: 10.32448/entupdates.633311
A. Kul, A. Bilen, N. Bilge, Köksal Sarıhan, H. Uzkeser, R. Dayanan, Fatih Baygutalp
Objectives : This study aimed to evaluate balance disorders and potential risk factors for falling in patients with hypothyroidism, as well as postural stability and the risk of falling. Methods : The participants' sex, age, body mass index (BMI), falls history in the past one year, and Falls Efficacy Scale - International (FES-I), Neuropathic Pain Diagnostic questionnaire (DN4) and clinical symptoms were recorded. The stability index (SI), weight distribution index (WDI) and falls risk analysis were performed for postural stability by objective computerised dynamic posturography. Results : 50 patients were matched for age and sex (mean age:41.7±11 years; age range:19-61 years) with 47 healthy (euthyroid) controls (mean age:39±9.6 years; age range:23-60 years). All SI, HL-WDI and falls risk scores, except FES-I, DN4 and NO-SI, were significantly higher in the patient group. In addition, other symptoms were present at a higher rate, with the exception of morning stiffness (p 0.05). However, there was a slight positive correlation between the existence of paraesthetic symptoms, a history of falling, and the overall SI and HL-WDI values (r>0.3 and p<0.05). Conclusions: It was determined that, as postural stability is affected in cases of hypothyroidism, balance becomes disordered and the risk of falls increases.  This increase in the risk of falls was associated with being hypothyroid, but not with FT4 or TSH levels or the other factors evaluated.
目的:本研究旨在评估甲状腺功能减退患者的平衡障碍和跌倒的潜在危险因素,以及姿势稳定性和跌倒风险。方法:记录参与者的性别、年龄、体重指数(BMI)、过去一年的跌倒史、国际跌倒疗效量表(FES-I)、神经性疼痛诊断问卷(DN4)和临床症状。稳定性指数(SI)、体重分布指数(WDI)和跌倒风险分析通过客观的计算机动态姿势描记术进行姿势稳定性。结果:50名患者的年龄和性别(平均年龄:41.7±11岁;年龄范围:19-61岁)与47名健康(甲状腺功能正常)对照组(平均年龄39±9.6岁;年龄区间:23-60岁)相匹配。除FES-I、DN4和NO-SI外,患者组的所有SI、HL-WDI和跌倒风险评分均显著较高。此外,除晨僵外,其他症状的出现率更高(p 0.05)。然而,审美障碍症状的存在、跌倒史与整体SI和HL-WDI值之间存在轻微的正相关(r>0.3和p<0.05),平衡变得紊乱,跌倒的风险增加。跌倒风险的增加与甲状腺功能减退有关,但与FT4或TSH水平或其他评估因素无关。
{"title":"Balance disorders and hypothyroidism: A rare cause worth remembering","authors":"A. Kul, A. Bilen, N. Bilge, Köksal Sarıhan, H. Uzkeser, R. Dayanan, Fatih Baygutalp","doi":"10.32448/entupdates.633311","DOIUrl":"https://doi.org/10.32448/entupdates.633311","url":null,"abstract":"Objectives : This study aimed to evaluate balance disorders and potential risk factors for falling in patients with hypothyroidism, as well as postural stability and the risk of falling. Methods : The participants' sex, age, body mass index (BMI), falls history in the past one year, and Falls Efficacy Scale - International (FES-I), Neuropathic Pain Diagnostic questionnaire (DN4) and clinical symptoms were recorded. The stability index (SI), weight distribution index (WDI) and falls risk analysis were performed for postural stability by objective computerised dynamic posturography. Results : 50 patients were matched for age and sex (mean age:41.7±11 years; age range:19-61 years) with 47 healthy (euthyroid) controls (mean age:39±9.6 years; age range:23-60 years). All SI, HL-WDI and falls risk scores, except FES-I, DN4 and NO-SI, were significantly higher in the patient group. In addition, other symptoms were present at a higher rate, with the exception of morning stiffness (p 0.05). However, there was a slight positive correlation between the existence of paraesthetic symptoms, a history of falling, and the overall SI and HL-WDI values (r>0.3 and p<0.05). Conclusions: It was determined that, as postural stability is affected in cases of hypothyroidism, balance becomes disordered and the risk of falls increases.  This increase in the risk of falls was associated with being hypothyroid, but not with FT4 or TSH levels or the other factors evaluated.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44496877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to Orbital Complications in Rhinosinusitis 鼻鼻窦炎眼眶并发症的探讨
IF 0.1 Pub Date : 2019-12-20 DOI: 10.32448/ENTUPDATES.576655
S. Çayır, S. Kayabaşı
Objective: Whilst orbital complications arising from acute rhinosinusitis are infrequent in contemporary practice, the spread of infection orbitally or intracranially can result in severe complications and a high mortality. This study aims to review cases of orbital complications arising from rhinosinusitis in the light of the published literature on the topic. Methods: Eight cases of individuals presenting to a particular clinic with the development of orbital complications following sinusitis within the previous four years were included in the study. The characteristic features of these cases in terms of diagnosis, treatment and follow-up were investigated. Results: The mean age of all cases was 29.5 years. In three cases, orbital abscess, and in five cases, preseptal cellulitis, were observed as complications. Both surgical and medical treatment was administered in three cases, while medical treatment alone was used for five cases. Conclusion: The region where the complications of rhinosinusitis are most commonly observed is the orbit, due to its proximity to the paranasal sinuses, especially the ethmoid cells. Where limitation of eye movements, proptosis, and a decrease in vision exists alongside an orbital abscess which itself has developed as a complication of sinusitis, surgical treatment is the most important option to consider to prevent complications.
目的:虽然急性鼻窦炎引起的眼眶并发症在当代临床中并不常见,但感染在眼眶或颅内的扩散可导致严重的并发症和高死亡率。本研究旨在回顾鼻鼻窦炎引起的眼眶并发症的病例,并结合已发表的相关文献。方法:在过去的四年里,有8例个体在鼻窦炎后的眼眶并发症出现在一个特定的诊所。分析这些病例在诊断、治疗和随访方面的特点。结果:所有病例平均年龄29.5岁。其中眼眶脓肿3例,间隔前蜂窝织炎5例。3例采用手术和药物治疗,5例仅采用药物治疗。结论:鼻窦炎并发症最常见的部位为眶部,因眶部靠近鼻窦,尤以鼻窦细胞为主。当眼球运动受限、眼球突出、视力下降并伴有眼眶脓肿时,手术治疗是预防并发症的最重要选择。
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引用次数: 0
Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media 慢性中耳炎患者对氧磷酶1基因多态性的检测
IF 0.1 Pub Date : 2019-12-06 DOI: 10.32448/entupdates.594272
K. Durmuş, Hande Küçük Kurtulgan, Adem Bora, M. Yıldırım, E. Altuntaş
Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism. Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion: The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group control may indicate a protective effect in COM.
目的:慢性中耳炎是一种多因素疾病,其发病机制尚未完全阐明。许多病因因素,包括遗传、咽鼓管功能障碍、自身免疫、感染、破骨细胞活性、细胞因子、内毒素和氧化应激引起的脂质过氧化产物,都被提出来解释慢性炎症是这种疾病的核心。本研究的目的是探讨COM发病机制与对氧磷酶1 (PON1)基因多态性之间的可能关系。方法:对2017年9月至11月在耳鼻喉科就诊并确诊为COM的49例患者进行调查。对照组由51名健康个体组成。采用聚合酶链反应(PCR) -限制性片段长度多态性(RFLP)方法对PON1 Q192R (rs662)多态性进行基因分型。结果:病例组与对照组PON1 (Q192)多态性存在情况比较,两组间差异无统计学意义(p=0.166, p>0.05)。组间比较PON1 (Q192)多态性类型,差异无统计学意义(p=0.261, p < 0.05)。结论:本研究是首次在COM病例中检测PON1多态性的研究。我们的研究结果未能表明PON1多态性与COM之间存在统计学意义上的关系。然而,值得注意的是,在对照组中较高的192RR多态性率可能表明对COM有保护作用。
{"title":"Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media","authors":"K. Durmuş, Hande Küçük Kurtulgan, Adem Bora, M. Yıldırım, E. Altuntaş","doi":"10.32448/entupdates.594272","DOIUrl":"https://doi.org/10.32448/entupdates.594272","url":null,"abstract":"Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism. Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion: The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group control may indicate a protective effect in COM.","PeriodicalId":41744,"journal":{"name":"ENT Updates","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47819688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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