Purpose: (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model.
Materials and methods: Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-κB), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed.
Results: Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively).
Conclusion: The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.
{"title":"Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis.","authors":"Didem Bezirci, Meltem Karsiyaka Hendek, Gonen Ozcan, Oguz Kul, Tugce Anteplioglu, Ebru Olgun","doi":"10.26650/eor.20241248958","DOIUrl":"10.26650/eor.20241248958","url":null,"abstract":"<p><strong>Purpose: </strong>(6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model.</p><p><strong>Materials and methods: </strong>Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-κB), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed.</p><p><strong>Results: </strong>Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively).</p><p><strong>Conclusion: </strong>The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.</p>","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.26650/eor.20241264315
Boris Saha, Sharique Alam, Daiasharailang Lyngdoh, Surendra Mishra
{"title":"Comparative evaluation of digital radiography, electronic apex locator and simultaneous working length determination on postoperative pain after root canal treatment: a randomized clinical trial","authors":"Boris Saha, Sharique Alam, Daiasharailang Lyngdoh, Surendra Mishra","doi":"10.26650/eor.20241264315","DOIUrl":"https://doi.org/10.26650/eor.20241264315","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.26650/eor.20241261599
Ahmet Nalbantoğlu, Deniz Yanık, Soner Albay
{"title":"The location of mandibular foramen relative to the occlusal plane: a study on anatolian dry mandible","authors":"Ahmet Nalbantoğlu, Deniz Yanık, Soner Albay","doi":"10.26650/eor.20241261599","DOIUrl":"https://doi.org/10.26650/eor.20241261599","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135342592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.26650/eor.20241175997
Elif Aslan, A. Canberk Ulusoy, B. Güniz Baksı, Ali Mert, B. Hakan Şen
{"title":"Cone beam computed tomography evaluation of c-shaped canal morphology in mandibular premolar teeth","authors":"Elif Aslan, A. Canberk Ulusoy, B. Güniz Baksı, Ali Mert, B. Hakan Şen","doi":"10.26650/eor.20241175997","DOIUrl":"https://doi.org/10.26650/eor.20241175997","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of three different primary teeth rotary instrument systems on the amount of apically extruded debris in pulpectomy of primary teeth","authors":"Müşfig Abdulhaligov, Nagehan Yılmaz, Tamer Tüzüner, Özgül Baygın, Cansu Emeksiz","doi":"10.26650/eor.20241057693","DOIUrl":"https://doi.org/10.26650/eor.20241057693","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135342383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.26650/eor.20241231589
Kübra Çakan
{"title":"Comparison of the Cameriere's third molar maturity index and Olze et al.’s stages of radiographic visibility of the root pulp in a Turkish population","authors":"Kübra Çakan","doi":"10.26650/eor.20241231589","DOIUrl":"https://doi.org/10.26650/eor.20241231589","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136067887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.26650/eor.20231302012
Mehdi Abed Kahnamouei, Mahmoud Bahari, Mohammad Chaharom, Soodabeh Kimyai, Mehdi Daneshpooy, Katayoun Katebi, Bahareh Elhami
{"title":"The effect of preheating on microhardness and flexural strength of bulk-fill resin composites: an in-vitro study","authors":"Mehdi Abed Kahnamouei, Mahmoud Bahari, Mohammad Chaharom, Soodabeh Kimyai, Mehdi Daneshpooy, Katayoun Katebi, Bahareh Elhami","doi":"10.26650/eor.20231302012","DOIUrl":"https://doi.org/10.26650/eor.20231302012","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136070082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress distribution of four implant supported overdentures with tilted standard-sized implants and mini implants","authors":"Işıl Turp, Volkan Turp, İlkin Tuncel, Aslıhan Üşümez","doi":"10.26650/eor.20241272144","DOIUrl":"https://doi.org/10.26650/eor.20241272144","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136209944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.26650/eor.20241312721
Muhammet Fidan, Ceren Mutluer, Mustafa Fidan
{"title":"Development of a scale for measuring university students’ attitudes toward oral health","authors":"Muhammet Fidan, Ceren Mutluer, Mustafa Fidan","doi":"10.26650/eor.20241312721","DOIUrl":"https://doi.org/10.26650/eor.20241312721","url":null,"abstract":"","PeriodicalId":41993,"journal":{"name":"European Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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