Pub Date : 2022-01-01DOI: 10.17721/fujcv10i1p13-29
A. Tiwari, D. Jaspal, Shradha Deshmukh, Preeti Mulay
Cheminformatics has entrenched itself as a core discipline within chemistry, biology, and allied sciences, more particularly in the field of Drug Design Discovery and Development. The article begins with a patent analysis of the progressing field of cheminformatics from 1996 to early 2021 using the Relecura and Lens patent database. It proceeds with a description of patents in various domains and aspects. The eye-catching mind map shows the landscape of cheminformatics patent search. The results reveal the star rating-wise patent counts and the trends in the sub-technological research areas. At the end of the article, quantum clustering and eminent directions towards the future of cheminformatics have been discussed. This study would provide the directions to academicians, techno enthusiasts, researchers, stakeholders, or investors and helps increase the awareness of the potential of cheminformatics and quantum clustering.
{"title":"Cheminformatics: A Patentometric Analysis","authors":"A. Tiwari, D. Jaspal, Shradha Deshmukh, Preeti Mulay","doi":"10.17721/fujcv10i1p13-29","DOIUrl":"https://doi.org/10.17721/fujcv10i1p13-29","url":null,"abstract":"Cheminformatics has entrenched itself as a core discipline within chemistry, biology, and allied sciences, more particularly in the field of Drug Design Discovery and Development. The article begins with a patent analysis of the progressing field of cheminformatics from 1996 to early 2021 using the Relecura and Lens patent database. It proceeds with a description of patents in various domains and aspects. The eye-catching mind map shows the landscape of cheminformatics patent search. The results reveal the star rating-wise patent counts and the trends in the sub-technological research areas. At the end of the article, quantum clustering and eminent directions towards the future of cheminformatics have been discussed. This study would provide the directions to academicians, techno enthusiasts, researchers, stakeholders, or investors and helps increase the awareness of the potential of cheminformatics and quantum clustering.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.17721/fujcv10i1p155-174
A. Chumak, Ruslana Khodzhaeva, Olena Kharchenko, V. Kotlyar, O. Kolomoitsev, Andrii Doroshenko
1,3,5-Triaryl-2-pyrazoline derivatives with a pyridine ring in position 1 and 2-benzimidazolyl or 2-benzothiazolyl bicycles in position 3 were synthesized. Spectral properties in solvents of similar polarity, i.e. aprotic acetonitrile and in protic methanol, were studied, complexation with cadmium and mercury ions in acetonitrile was elucidated as well. Quantum-chemical modeling with application of the elements of Bader's atoms-in-molecules (AIM) theory of the title molecules conformational structure and 1:1 stoichiometry complexes formed with polyvalent metals of various nature (Mg, Zn, Cd, Pb, Hg, Ba) was conducted. The principal possibility of “nitrogen-sulfur” switching of the metal ions binding sites for the benzothiazole derivative was revealed, and makes possible to classify this compound as “smart ligand”.
{"title":"Complexation of 1,3-dihetaryl-5-phenyl-2-pyrazoline Derivatives with Polyvalent Metal Ions: Quantum Chemical Modeling and Experimental Investigation","authors":"A. Chumak, Ruslana Khodzhaeva, Olena Kharchenko, V. Kotlyar, O. Kolomoitsev, Andrii Doroshenko","doi":"10.17721/fujcv10i1p155-174","DOIUrl":"https://doi.org/10.17721/fujcv10i1p155-174","url":null,"abstract":"1,3,5-Triaryl-2-pyrazoline derivatives with a pyridine ring in position 1 and 2-benzimidazolyl or 2-benzothiazolyl bicycles in position 3 were synthesized. Spectral properties in solvents of similar polarity, i.e. aprotic acetonitrile and in protic methanol, were studied, complexation with cadmium and mercury ions in acetonitrile was elucidated as well. Quantum-chemical modeling with application of the elements of Bader's atoms-in-molecules (AIM) theory of the title molecules conformational structure and 1:1 stoichiometry complexes formed with polyvalent metals of various nature (Mg, Zn, Cd, Pb, Hg, Ba) was conducted. The principal possibility of “nitrogen-sulfur” switching of the metal ions binding sites for the benzothiazole derivative was revealed, and makes possible to classify this compound as “smart ligand”.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical transformation of Ceftriaxone with the reaction of potassium caroate has been proposed. The appearance of a new wave gives the possibility of developing a new procedure for the quantitative determination of Ceftriaxone. The obtained results of accuracy and precision are as follows: RSD = 1.63-2.25 %, δ = 0.33-0.96 %. LOD = 0.1 µg/mL, LOQ = 0.33 µg/mL.
{"title":"Development and Validation of a Simple Procedure for the Kinetic Spectrophotometric Quantitative Determination of Ceftriaxone Using Potassium Caroate","authors":"M. Blazheyevskiy, Y. Serdiukova, S. Karpova","doi":"10.17721/fujcv10i1p1-12","DOIUrl":"https://doi.org/10.17721/fujcv10i1p1-12","url":null,"abstract":"A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical transformation of Ceftriaxone with the reaction of potassium caroate has been proposed. The appearance of a new wave gives the possibility of developing a new procedure for the quantitative determination of Ceftriaxone. The obtained results of accuracy and precision are as follows: RSD = 1.63-2.25 %, δ = 0.33-0.96 %. LOD = 0.1 µg/mL, LOQ = 0.33 µg/mL.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.17721/fujcv10i1p84-100
I. Sokolovskaya
Inflammatory diseases cause health disorders which result in a reduction of the population. That is why this medical problem is considered to be a very important one. The human immune system is responsible for protecting the body from infections of various origins, while inducing chronic inflammation (characterized by a long, often invisible course) which can result in proneness to recurrence, complications and resistance to therapy. The authors of the article analyzed and proved that there are immune status shifts in patients with chronic nonspecific inflammatory processes depending on the pathogen, phase and level of damage.
{"title":"Features of Indicators of Blood General Clinical Analysis and the Summary Analysis of an Organism’s General Reactivity at Chronic Inflammatory Process","authors":"I. Sokolovskaya","doi":"10.17721/fujcv10i1p84-100","DOIUrl":"https://doi.org/10.17721/fujcv10i1p84-100","url":null,"abstract":"Inflammatory diseases cause health disorders which result in a reduction of the population. That is why this medical problem is considered to be a very important one. The human immune system is responsible for protecting the body from infections of various origins, while inducing chronic inflammation (characterized by a long, often invisible course) which can result in proneness to recurrence, complications and resistance to therapy. The authors of the article analyzed and proved that there are immune status shifts in patients with chronic nonspecific inflammatory processes depending on the pathogen, phase and level of damage.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67433068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the study was to investigate the relationship between the vitamin D content, melatonin and the characteristics of pineal gland calcifications in patients with malignant tumors of the bones of the lower extremities. Vitamin D deficiency and pineal gland calcifications are observed in almost 100 % of patients with malignant tumors of the lower extremities’ bones. The high heterogeneity of calcifications and its dynamics during the treatment of patients may indicate the processes of their litholysis and dissolution.
{"title":"Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors","authors":"O. Drobotun, M. Kolotilov, M. Safonov","doi":"10.17721/fujcv9i1p63-69","DOIUrl":"https://doi.org/10.17721/fujcv9i1p63-69","url":null,"abstract":"The aim of the study was to investigate the relationship between the vitamin D content, melatonin and the characteristics of pineal gland calcifications in patients with malignant tumors of the bones of the lower extremities. Vitamin D deficiency and pineal gland calcifications are observed in almost 100 % of patients with malignant tumors of the lower extremities’ bones. The high heterogeneity of calcifications and its dynamics during the treatment of patients may indicate the processes of their litholysis and dissolution.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43530185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Onen, James Watmon, Timothy Omara, Daniel Ocira
Persuasive adverts and exaggeration of health benefits from consumption of herbal products as well as the mental picture of ‘natural’ is ‘safe’ has boosted traditional medicine use in Uganda. However, herbal products may be unsafe due to the possibility of their contamination with mycotoxins. In this study, we quantified the levels of aflatoxins (B1, B2, G1 and G2) in Real Koff product, Eddagala ly’e kifuba n’e senyiga, Omusujja, Cough mixture and Fever herbal products sold in Kampala, Uganda using high performance liquid chromatography-tandem mass spectrometry. The associated consumption health risks were assessed using the hazard index method. Only aflatoxin B1 was detected in 60% of the samples, with 40% of these surpassing WHO guidelines of ≤ 5 µg/kg. The hazard indices were all less than 1, implying that Ugandans who heavily rely on the herbal products are exposed to aflatoxins at sublethal doses which may lead to chronic effects in the long run. Studies using a larger sample size should assess whether the current observation is a routine occurrence or a sporadic event.
{"title":"Aflatoxin content and health risks associated with consumption of some herbal products sold in Kampala, Uganda","authors":"Patrick Onen, James Watmon, Timothy Omara, Daniel Ocira","doi":"10.17721/fujcv9i1p1-8","DOIUrl":"https://doi.org/10.17721/fujcv9i1p1-8","url":null,"abstract":"Persuasive adverts and exaggeration of health benefits from consumption of herbal products as well as the mental picture of ‘natural’ is ‘safe’ has boosted traditional medicine use in Uganda. However, herbal products may be unsafe due to the possibility of their contamination with mycotoxins. In this study, we quantified the levels of aflatoxins (B1, B2, G1 and G2) in Real Koff product, Eddagala ly’e kifuba n’e senyiga, Omusujja, Cough mixture and Fever herbal products sold in Kampala, Uganda using high performance liquid chromatography-tandem mass spectrometry. The associated consumption health risks were assessed using the hazard index method. Only aflatoxin B1 was detected in 60% of the samples, with 40% of these surpassing WHO guidelines of ≤ 5 µg/kg. The hazard indices were all less than 1, implying that Ugandans who heavily rely on the herbal products are exposed to aflatoxins at sublethal doses which may lead to chronic effects in the long run. Studies using a larger sample size should assess whether the current observation is a routine occurrence or a sporadic event.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48289502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article considers the chemistry and technology of the methods of roasting and extracting different types of coffees, Arabica and Robusta. Parameters and equipment to improve roasting in microwave ovens and distillation of coffee with water-alcohol vapors demonstrate that the weight loss of green coffee beans has decreased from 18-20% to 12-15%. Mass spectroscopic analysis of extracts of coffee substances with water vapor and alcohol identified 36 substances, 14 of them being the main substances that create a unique bouquet - the taste and aroma of coffee. We have experimentally demonstrated that aqueous distillates of coffee extracts accelerate 1.5-2.5 times the metabolism of ethyl alcohol in the human body to the acceptable concentrations of 0.2 ‰ per ppm.
{"title":"Chemistry and technology of roasting and extracting different types of coffees with preservation of taste and aromas","authors":"S. Kurta, Mаria Yakubiak, O. Khatsevich","doi":"10.17721/fujcv9i1p31-43","DOIUrl":"https://doi.org/10.17721/fujcv9i1p31-43","url":null,"abstract":"The article considers the chemistry and technology of the methods of roasting and extracting different types of coffees, Arabica and Robusta. Parameters and equipment to improve roasting in microwave ovens and distillation of coffee with water-alcohol vapors demonstrate that the weight loss of green coffee beans has decreased from 18-20% to 12-15%. Mass spectroscopic analysis of extracts of coffee substances with water vapor and alcohol identified 36 substances, 14 of them being the main substances that create a unique bouquet - the taste and aroma of coffee. We have experimentally demonstrated that aqueous distillates of coffee extracts accelerate 1.5-2.5 times the metabolism of ethyl alcohol in the human body to the acceptable concentrations of 0.2 ‰ per ppm.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48338679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Titov, N. Belyavina, M. Slobodyanik, O. Nakonechna, N. Strutynska
Effects of substitution of the Strontium atoms with smaller Calcium atoms on the structural features of the Ruddlesden-Popper SrLa2Sc2O7 two-slab compound is established. The crystal structure of orthorhombic Sr0.85Ca0.15La2Sc2O7 phase with maximum degree of substitution was determined by the Rietveld method (Fmmm space group, a = 0.5766(2) nm, b = 0.5743(2) nm, c = 2.0522(7) nm). Comparison of the structural features of SrLa2Sc2O7 and Sr0.85Ca0.15La2Sc2O7 shows that such type of substitution leads to a decrease in the (La,Sr)2 - О2 interblock bond length (from 0.222 (2) nm at x = 0 to 0.215 (1) nm at x = 0.15). The decrease in interblock bond length brings the constitution of the two-dimensional structure Sr1-хCaxLa2Sc2O7 closer to the structure of the three-dimensional perovskite, leads to its instability at х > 0.15 and gives a reason to conclude that this factor causes a limitation of region of the Sr1-хCaxLa2Sc2O7 solid solutions with a slab perovskite-like structure. Presence of such structure changes is the precondition for regulation of structural-dependent features of the materials on the base of scandates alkaline-earth and rare earth metals.
{"title":"Effect of strontium atoms substitution on the features of two-slab structure of Sr1-xCaxLa2Sc2O7 scandates","authors":"Y. Titov, N. Belyavina, M. Slobodyanik, O. Nakonechna, N. Strutynska","doi":"10.17721/fujcv9i1p44-50","DOIUrl":"https://doi.org/10.17721/fujcv9i1p44-50","url":null,"abstract":"Effects of substitution of the Strontium atoms with smaller Calcium atoms on the structural features of the Ruddlesden-Popper SrLa2Sc2O7 two-slab compound is established. The crystal structure of orthorhombic Sr0.85Ca0.15La2Sc2O7 phase with maximum degree of substitution was determined by the Rietveld method (Fmmm space group, a = 0.5766(2) nm, b = 0.5743(2) nm, c = 2.0522(7) nm). Comparison of the structural features of SrLa2Sc2O7 and Sr0.85Ca0.15La2Sc2O7 shows that such type of substitution leads to a decrease in the (La,Sr)2 - О2 interblock bond length (from 0.222 (2) nm at x = 0 to 0.215 (1) nm at x = 0.15). The decrease in interblock bond length brings the constitution of the two-dimensional structure Sr1-хCaxLa2Sc2O7 closer to the structure of the three-dimensional perovskite, leads to its instability at х > 0.15 and gives a reason to conclude that this factor causes a limitation of region of the Sr1-хCaxLa2Sc2O7 solid solutions with a slab perovskite-like structure. Presence of such structure changes is the precondition for regulation of structural-dependent features of the materials on the base of scandates alkaline-earth and rare earth metals.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48066743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Samoilenko, L. Yashchenko, N. Yarova, O. Babich, O. Brovko
Hemp wood core (HWC) filled Si-containing epoxyurethane biocomposites, in which diane epoxy resin was replaced with epoxidized soybean oil (ESO), were obtained. It was shown that the tensile strength of ESO-containing polymer was higher, and the flexural strength was lower than those of original polymer. HWC was especially effective strengthening filler for modified epoxyurethanes, because in that case mechanical properties of composites were higher than those of unfilled polymer matrices. Particularly, flexural and tensile strength of unfilled epoxyurethane with maximum content of ESO were 8.1 and 6.8 MPa respectively, while in corresponding composite they reached 17.3 and 15.7 MPa.
{"title":"Physicomechanical Properties of Epoxyurethane Biocomposites Strengthened with Hemp Wood Core","authors":"T. Samoilenko, L. Yashchenko, N. Yarova, O. Babich, O. Brovko","doi":"10.17721/fujcv9i1p9-18","DOIUrl":"https://doi.org/10.17721/fujcv9i1p9-18","url":null,"abstract":"Hemp wood core (HWC) filled Si-containing epoxyurethane biocomposites, in which diane epoxy resin was replaced with epoxidized soybean oil (ESO), were obtained. It was shown that the tensile strength of ESO-containing polymer was higher, and the flexural strength was lower than those of original polymer. HWC was especially effective strengthening filler for modified epoxyurethanes, because in that case mechanical properties of composites were higher than those of unfilled polymer matrices. Particularly, flexural and tensile strength of unfilled epoxyurethane with maximum content of ESO were 8.1 and 6.8 MPa respectively, while in corresponding composite they reached 17.3 and 15.7 MPa.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47455004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fused chromones are attracting increasing attention as novel therapeutic agents due to their wide distribution in nature, effective bioactivities and low toxicity. 6-Carbonyl-7-hydroxychromones proved to be versatile synthons for the synthesis of linear hetarenochromones by annulation of heterocycle to the chromone core. The present review is focused on the syntheses of furo[3,2-g]chromones, pyrano[3,2-g]chromones and some of their N-containing analogues, namely chromeno[6,7-d]isoxazoles, pyrano[3’,2’:6,7]chromeno[4,3-b]pyridine-5,11-diones and pyrano[3’,2’:6,7]chromeno[4,3-c]pyridine-5,11-diones based on the 7-hydroxy-6-formylchromones or 7-hydroxy-6-acetylchromones and shows the current state of research to date. The methods for the synthesis of the starting 7-hydroxy-6-formylchromones and 7-hydroxy-6-acetylchromones have been also mentioned. The biological activity of naturally occurring and modified synthetic linear hetarenochromones has been also represented.
{"title":"Synthesis of linear hetarenochromones based on 7-hydroxy-6-formyl(acetyl)chromones","authors":"Tatyana Shokol, N. Gorbulenko, Khilya Volodymyr","doi":"10.17721/fujcv9i1p70-96","DOIUrl":"https://doi.org/10.17721/fujcv9i1p70-96","url":null,"abstract":"Fused chromones are attracting increasing attention as novel therapeutic agents due to their wide distribution in nature, effective bioactivities and low toxicity. 6-Carbonyl-7-hydroxychromones proved to be versatile synthons for the synthesis of linear hetarenochromones by annulation of heterocycle to the chromone core. The present review is focused on the syntheses of furo[3,2-g]chromones, pyrano[3,2-g]chromones and some of their N-containing analogues, namely chromeno[6,7-d]isoxazoles, pyrano[3’,2’:6,7]chromeno[4,3-b]pyridine-5,11-diones and pyrano[3’,2’:6,7]chromeno[4,3-c]pyridine-5,11-diones based on the 7-hydroxy-6-formylchromones or 7-hydroxy-6-acetylchromones and shows the current state of research to date. The methods for the synthesis of the starting 7-hydroxy-6-formylchromones and 7-hydroxy-6-acetylchromones have been also mentioned. The biological activity of naturally occurring and modified synthetic linear hetarenochromones has been also represented.","PeriodicalId":42056,"journal":{"name":"French-Ukrainian Journal of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48888804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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