{"title":"A rare case of toxic epidermal necrolysis (TEN) like presentation of bullous pemphigoid with coexistent esophageal candidiasis in an elderly man","authors":"Preema Sinha, Lekshmipriya Krishnan, Abhishek Mahato, Priyank Dhiman, M. Madakshira, Vinod Sharma","doi":"10.4103/ijdpdd.ijdpdd_30_22","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_30_22","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129983879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ijdpdd.ijdpdd_38_21
Sushanti Jadhav, A. Dongre, B. Darkase
{"title":"Palisaded neutrophilic granulomatous dermatitis in a case of seronegative arthritis","authors":"Sushanti Jadhav, A. Dongre, B. Darkase","doi":"10.4103/ijdpdd.ijdpdd_38_21","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_38_21","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114747742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ijdpdd.ijdpdd_3_22
Rashmiben Agharia, Hitarth N. Mehta, Ankit H. Bharti, Manal D. Dave, V. Patel
Context: Owing to myriad clinical presentations in leprosy, it becomes a diagnostic challenge. Dermoscopy visualizes skin structures not normally visible to the naked eye, providing additional morphological information. Aims: The aim of this work was to study and evaluate the various dermoscopic patterns of different types of leprosy and lepra reactions and to assess their association with clinical and histopathology. Materials and Methods: A descriptive cross-sectional study was undertaken at dermatology OPD over 1.5 years after ethical approval. Thorough clinical, physical, local examination, and gross photographs were taken. Dermoscopy was taken and the images were analyzed for dermoscopic features. Biopsy from the same lesion was taken. Results: A total of 50 naïve cases of leprosy and lepra reactions with skin phototypes of IV to VI were studied. Males (30) outnumbered females (20). The most common type was Borderline tuberculoid Leprosy (BT) (21,42%). We observed yellowish-brown and white structureless areas histologically corresponding to dermal granulomatous infiltrate, whereas vascular findings predominantly of linear irregular vessels and variable loss of appendageal structures histologically corresponding to perivascular and periappendageal infiltrate respectively were predominant features throughout the spectrum. Appendageal structures were markedly reduced in the tuberculoid pole. We noted reduced pigmentary network towards tuberculoid pole whereas accentuation towards the lepromatous pole. Follicular plugging, scaling, and shiny white areas were additional features in the lepra reaction. Conclusion: Yellowish brown and white structureless areas, associated vascular findings predominantly of linear irregular vessels, and variable loss of appendageal structures were key features throughout the spectrum. Sunflower-like appearance, rosette-like pattern and milky red background in histoid leprosy, target-like pattern in type 2 lepra reaction were the unique dermoscopic findings from our study.
{"title":"Dermoscopic, clinical, and histopathological aspects of leprosy and lepra reaction cases: An observational cross-sectional study","authors":"Rashmiben Agharia, Hitarth N. Mehta, Ankit H. Bharti, Manal D. Dave, V. Patel","doi":"10.4103/ijdpdd.ijdpdd_3_22","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_3_22","url":null,"abstract":"Context: Owing to myriad clinical presentations in leprosy, it becomes a diagnostic challenge. Dermoscopy visualizes skin structures not normally visible to the naked eye, providing additional morphological information. Aims: The aim of this work was to study and evaluate the various dermoscopic patterns of different types of leprosy and lepra reactions and to assess their association with clinical and histopathology. Materials and Methods: A descriptive cross-sectional study was undertaken at dermatology OPD over 1.5 years after ethical approval. Thorough clinical, physical, local examination, and gross photographs were taken. Dermoscopy was taken and the images were analyzed for dermoscopic features. Biopsy from the same lesion was taken. Results: A total of 50 naïve cases of leprosy and lepra reactions with skin phototypes of IV to VI were studied. Males (30) outnumbered females (20). The most common type was Borderline tuberculoid Leprosy (BT) (21,42%). We observed yellowish-brown and white structureless areas histologically corresponding to dermal granulomatous infiltrate, whereas vascular findings predominantly of linear irregular vessels and variable loss of appendageal structures histologically corresponding to perivascular and periappendageal infiltrate respectively were predominant features throughout the spectrum. Appendageal structures were markedly reduced in the tuberculoid pole. We noted reduced pigmentary network towards tuberculoid pole whereas accentuation towards the lepromatous pole. Follicular plugging, scaling, and shiny white areas were additional features in the lepra reaction. Conclusion: Yellowish brown and white structureless areas, associated vascular findings predominantly of linear irregular vessels, and variable loss of appendageal structures were key features throughout the spectrum. Sunflower-like appearance, rosette-like pattern and milky red background in histoid leprosy, target-like pattern in type 2 lepra reaction were the unique dermoscopic findings from our study.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"231 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115501017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ijdpdd.ijdpdd_5_23
R. Tirumalae, J. Prabhu
{"title":"MicroRNA Expression Profile in Mycosis Fungoides – Preliminary Findings","authors":"R. Tirumalae, J. Prabhu","doi":"10.4103/ijdpdd.ijdpdd_5_23","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_5_23","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133410221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ijdpdd.ijdpdd_107_20
Shweta Patil, H. Pathave, C. Nayak
Background: Among various nail disorders encountered in dermatology outpatient department, nail psoriasis is not uncommon. Around 80%–90% of patients with psoriasis present with nail involvement at some point in their life. In 1%–5% of patients, alterations compatible with nail psoriasis may also occur in the absence of cutaneous lesions. There is limited literature on nail psoriasis especially in Indian patients. Objective: The present study was undertaken to evaluate clinical, histopathological, and dermoscopic features in nail psoriasis and its impact on quality of life. Materials and Methods: All clinically suspected cases of nail psoriasis were included in the study. Clinical parameters and dermoscopic findings were observed and noted. Nail biopsy was performed to confirm the findings. Impact on quality of life was evaluated by correlating Nail Psoriasis Severity Index (NAPSI) score and nail psoriasis quality of life scale (NPQ10) score. Results: Of 50 patients with clinically suspected nail psoriasis, skin involvement was seen in 45 (90%), and 5 (10%) had only nail involvement. The mean NAPSI score was 34.34 in our study. The most common clinical nail finding was pitting (38 [76%]) followed by onycholysis (31 [62%]). The most common dermoscopic finding was pitting (39 [76%]) followed by onycholysis (32 [64%]). Histopathologically, the most common finding was parakeratosis (41 [82%]) followed by focal hypergranulosis (40 [80%]). The majority of the patients (21 [42%]) had NPQ10 (modified) score between 10 and 20, and moderate positive correlation between NAPSI score and NPQ10 scale score was observed. Limitations: Small sample size and no control group. Conclusion: Nail psoriasis does impact the quality of life of patients especially in females who feel embarrassed in social gatherings and workplace. Nail biopsy, though painful and difficult to perform, is the most efficient method to diagnose nail psoriasis.
{"title":"A cross-sectional observational study of clinical, histopathological, and dermoscopic correlation in patients with nail psoriasis at a tertiary care hospital","authors":"Shweta Patil, H. Pathave, C. Nayak","doi":"10.4103/ijdpdd.ijdpdd_107_20","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_107_20","url":null,"abstract":"Background: Among various nail disorders encountered in dermatology outpatient department, nail psoriasis is not uncommon. Around 80%–90% of patients with psoriasis present with nail involvement at some point in their life. In 1%–5% of patients, alterations compatible with nail psoriasis may also occur in the absence of cutaneous lesions. There is limited literature on nail psoriasis especially in Indian patients. Objective: The present study was undertaken to evaluate clinical, histopathological, and dermoscopic features in nail psoriasis and its impact on quality of life. Materials and Methods: All clinically suspected cases of nail psoriasis were included in the study. Clinical parameters and dermoscopic findings were observed and noted. Nail biopsy was performed to confirm the findings. Impact on quality of life was evaluated by correlating Nail Psoriasis Severity Index (NAPSI) score and nail psoriasis quality of life scale (NPQ10) score. Results: Of 50 patients with clinically suspected nail psoriasis, skin involvement was seen in 45 (90%), and 5 (10%) had only nail involvement. The mean NAPSI score was 34.34 in our study. The most common clinical nail finding was pitting (38 [76%]) followed by onycholysis (31 [62%]). The most common dermoscopic finding was pitting (39 [76%]) followed by onycholysis (32 [64%]). Histopathologically, the most common finding was parakeratosis (41 [82%]) followed by focal hypergranulosis (40 [80%]). The majority of the patients (21 [42%]) had NPQ10 (modified) score between 10 and 20, and moderate positive correlation between NAPSI score and NPQ10 scale score was observed. Limitations: Small sample size and no control group. Conclusion: Nail psoriasis does impact the quality of life of patients especially in females who feel embarrassed in social gatherings and workplace. Nail biopsy, though painful and difficult to perform, is the most efficient method to diagnose nail psoriasis.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125088015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/ijdpdd.ijdpdd_29_22
Bhavya Swarnkar, K. Sahni, Hena Khandakar, S. Agarwal
Myopericytoma is a rare soft tissue tumour which orginates from pericytes. Histopathology shows nodular perivascular proliferation of cells with myoid differentiation. Myopericytomatosis and multifocal myopericytomas are the two uncommon variants of this entity. We report an uncommon case of multifocal myopericytomas over the sole.
{"title":"Multifocal myopericytomas: Rare soft tissue tumor over the sole","authors":"Bhavya Swarnkar, K. Sahni, Hena Khandakar, S. Agarwal","doi":"10.4103/ijdpdd.ijdpdd_29_22","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_29_22","url":null,"abstract":"Myopericytoma is a rare soft tissue tumour which orginates from pericytes. Histopathology shows nodular perivascular proliferation of cells with myoid differentiation. Myopericytomatosis and multifocal myopericytomas are the two uncommon variants of this entity. We report an uncommon case of multifocal myopericytomas over the sole.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124973431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/ijdpdd.ijdpdd_79_21
Aishni Shah, Dhruv M. Patel, J. Tandel, P. Nair
{"title":"Eccrine poroma under the dermatoscope","authors":"Aishni Shah, Dhruv M. Patel, J. Tandel, P. Nair","doi":"10.4103/ijdpdd.ijdpdd_79_21","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_79_21","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126107143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/ijdpdd.ijdpdd_83_21
Jose A Cervantes, Kavina Patel, Wendi E Wohltmann, J. Wisell
Gelfoam, an absorbable gelatin material that can carry thrombin and provide a matrix for the clotting cascade, is commonly used in dermatologic surgery to obtain hemostasis. Gelfoam application is often well tolerated, with minimal surgical site reaction. Gelfoam may be an incidental histopathologic finding following cutaneous surgery, typically without any clinical sequelae. Both dermatologic surgeons and pathologists should be familiar with this histopathologic finding to eliminate confusion and to avoid additional intervention. We present a case of a 76-year-old man with an interesting histopathologic finding of basophilic material predominantly overlying and among keratinocytes in an epithelializing surgical defect that was covered with Gelfoam.
{"title":"Histopathologic findings following hemostasis with Gelfoam","authors":"Jose A Cervantes, Kavina Patel, Wendi E Wohltmann, J. Wisell","doi":"10.4103/ijdpdd.ijdpdd_83_21","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_83_21","url":null,"abstract":"Gelfoam, an absorbable gelatin material that can carry thrombin and provide a matrix for the clotting cascade, is commonly used in dermatologic surgery to obtain hemostasis. Gelfoam application is often well tolerated, with minimal surgical site reaction. Gelfoam may be an incidental histopathologic finding following cutaneous surgery, typically without any clinical sequelae. Both dermatologic surgeons and pathologists should be familiar with this histopathologic finding to eliminate confusion and to avoid additional intervention. We present a case of a 76-year-old man with an interesting histopathologic finding of basophilic material predominantly overlying and among keratinocytes in an epithelializing surgical defect that was covered with Gelfoam.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128275265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/ijdpdd.ijdpdd_70_21
P. Balasubramanian, Chhakchhuak Laldinthari, Robert Lalnunpuia
Introduction: Remdesivir and favipiravir are two antiviral medicines used in the treatment of Covid-19 infection widely. The studies pertaining to the mucocutaneous adverse events of these two drugs are scarce. Hence, we performed a systematic review to bridge the above gap. Materials and Methods: The study is performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. All original articles, case series, and case reports pertaining to mucocutaneous adverse drug reactions caused by remdesivir and favipiravir, while any of these drugs were administered in Covid-19-infected patients, were included in the present study. Results: Six articles were identified pertaining to the mucocutaneous adverse reactions of remdesivir, of which two were original articles and four were case reports. Four case reports pertaining to the mucocutaneous adverse events of favipiravir are included in this study. The details regarding the same are elaborated in the main manuscript. Conclusion: In the present systematic analysis, the mucocutaneous adverse events of the two widely used antiviral medications in Covid-19 were described. This articles throws light on the aspects which are hardly reported or discussed in the literature.
{"title":"Mucocutaneous adverse effects of remdesivir and favipiravir in patients with Covid-19 infection: A systematic review","authors":"P. Balasubramanian, Chhakchhuak Laldinthari, Robert Lalnunpuia","doi":"10.4103/ijdpdd.ijdpdd_70_21","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_70_21","url":null,"abstract":"Introduction: Remdesivir and favipiravir are two antiviral medicines used in the treatment of Covid-19 infection widely. The studies pertaining to the mucocutaneous adverse events of these two drugs are scarce. Hence, we performed a systematic review to bridge the above gap. Materials and Methods: The study is performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. All original articles, case series, and case reports pertaining to mucocutaneous adverse drug reactions caused by remdesivir and favipiravir, while any of these drugs were administered in Covid-19-infected patients, were included in the present study. Results: Six articles were identified pertaining to the mucocutaneous adverse reactions of remdesivir, of which two were original articles and four were case reports. Four case reports pertaining to the mucocutaneous adverse events of favipiravir are included in this study. The details regarding the same are elaborated in the main manuscript. Conclusion: In the present systematic analysis, the mucocutaneous adverse events of the two widely used antiviral medications in Covid-19 were described. This articles throws light on the aspects which are hardly reported or discussed in the literature.","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122331772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.4103/ijdpdd.ijdpdd_20_22
Richa Kumar, Navya Donaparthi
{"title":"Scarring alopecia of scalp: It is not always about the hair!","authors":"Richa Kumar, Navya Donaparthi","doi":"10.4103/ijdpdd.ijdpdd_20_22","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_20_22","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134427951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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