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A clinico-mycological study of dermatophytoses and their in-vitro sensitivity to antifungal drugs 皮肤真菌的临床真菌学研究及其对抗真菌药物的体外敏感性
Pub Date : 2022-07-01 DOI: 10.4103/ijdpdd.ijdpdd_41_21
Manjunath Kadnur, Shishira R. Jartarkar, Girish Narayanaswamy, Ashwath Manoj Kumar, Sheen J Arora, Thushara Balakrishnan
Background: There is an increase in the frequency of resistant and recurrent dermatophyte infections in India. We undertook a study to isolate the organisms in different clinical presentations and to study their sensitivity to clotrimazole, miconazole, fluconazole, and griseofulvin. Aims: The aim of this article was to study the clinico-mycological pattern of dermatophytes and their in-vitro sensitivity to commonly used antifungals. Objectives: The objectives were as follows: (1) to study the clinico-mycological patterns of dermatophytosis and (2) to study the in-vitro sensitivity patterns of culture isolates to clotrimazole, miconazole, fluconazole, and griseofulvin. Materials and Methods: A total number of 48 patients were included in the study. The study period was from August 2019 to February 2021. Skin scrapings and nail clippings were inoculated in Sabouraud dextrose agar. Isolates were identified based on gross colony characteristics and microscopic morphology of their micro- and macroconidia and accessory structures. The isolates were then transferred to sterile distilled water in vials and stored. The clinical isolates stored in the stock solution were subcultured on to Potato dextrose agar. Then, the antifungal disks and Griseofulvin E strip were applied on to the plates. The zones of inhibition around the disks were measured and recorded. In the case of E strip, the minimum inhibitory concentration value is read from the scale in terms of µg/mL, where the ellipse edge intersects the strip. Results: The total number of cases included were 48. Commonest clinical presentation was co-occurrence of Tinea cruris and corporis (33%). Trichophyton mentagrophytes was isolated in 56% of cases. Isolates showed highest sensitivity to clotrimazole (87.5%) followed by miconazole (60.4%). Only 8.3% were sensitive to fluconazole and 37.5% were sensitive to griseofulvin. Conclusion: T. mentagrophytes is the causative organism in significant numbers of dermatophytic infections. Though broth dilution is the standard method for sensitivity assay of dermatophytes, disk diffusion method could become a more simple alternative.
背景:在印度,耐药和复发性皮肤真菌感染的频率有所增加。我们进行了一项研究,以分离不同临床表现的微生物,并研究它们对克霉唑、咪康唑、氟康唑和灰黄霉素的敏感性。目的:研究皮肤真菌的临床-真菌学模式及其对常用抗真菌药物的体外敏感性。目的:(1)研究皮肤真菌病的临床真菌学特征;(2)研究培养菌株对克霉唑、咪康唑、氟康唑和灰黄霉素的体外敏感性特征。材料与方法:共纳入48例患者。研究时间为2019年8月至2021年2月。将皮肤屑和指甲屑接种于沙伯罗德葡萄糖琼脂中。根据菌落特征和微、大分生孢子及其附属结构的显微形态鉴定分离菌株。然后将分离物转移到无菌蒸馏水中并储存在小瓶中。将储存在原液中的临床分离株传代到马铃薯葡萄糖琼脂上。然后,将抗真菌片和灰黄霉素E条涂于平板上。测量并记录了圆盘周围的抑制区。在E条的情况下,从刻度中读取最小抑制浓度值,以µg/mL为单位,其中椭圆边缘与条相交。结果:共纳入病例48例。最常见的临床表现为股癣和体癣同时发生(33%)。在56%的病例中分离到毛藓。菌株对克霉唑的敏感性最高(87.5%),其次是咪康唑(60.4%)。对氟康唑和灰黄霉素敏感的分别为8.3%和37.5%。结论:在大量的皮肤真菌感染中,mentagrophytot是病原菌。虽然肉汤稀释法是皮癣菌敏感性测定的标准方法,但纸片扩散法可以成为一种更简单的替代方法。
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引用次数: 1
Erythroderma secondary to dermatophytosis 继发于皮肤植物病的红皮病
Pub Date : 2022-07-01 DOI: 10.4103/ijdpdd.ijdpdd_45_21
Aseefa Vellattuchola, T. Anoop, P. Mathew, S. Rajiv
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引用次数: 0
Dermatosis neglecta in inpatients of a tertiary care center: A case series 三级医疗中心住院病人的皮肤病忽视:一个病例系列
Pub Date : 2022-07-01 DOI: 10.4103/ijdpdd.ijdpdd_44_21
Sruthi Kareddy, Spoorthy Babu, Mamatha Pappala
Background: Dermatosis neglecta (DN) is an underdiagnosed localized pigmentary disorder, characterized by asymptomatic hyperpigmented patches and plaques with adherent scales in an inadequately cleansed area. It is a diagnostic challenge leading to unnecessary interventions and burden to patients. Dermoscopy is a noninvasive handy diagnostic tool, though its utility in the diagnosis of DN is unexplored. Objective: To describe the various clinical and dermoscopic patterns in patients with DN. Materials and Methods: An observational study in 10 admitted patients of a tertiary hospital with DN was done, who consulted in department of dermatology in view of hyperpigmented lesions. After a thorough history and clinical examination, dermoscopy was done over the lesions. Results: In 10 patients, DN was confirmed with a resolution of part of lesion on the application of water-soaked gauze. On dermoscopy, dark-brown polygonal, cornflake-like scales are seen arranged in a mosaic pattern with intervening normal skin, sometimes over an erythematous background. On further probing, most patients gave the history of unintentional neglect of the affected part related to their primary illness. Limitations: Small sample size. Conclusions: DN is an underreported localized hyperpigmented disorder, mimicking other dermatoses. It should always be kept in mind in patients with morbidities that lead to the inability to maintain hygiene in the relevant areas, which may not be the classically described sites of DN. Dermoscopy helps to differentiate it from other hyperpigmented lesions, especially in its milder forms, avoiding the act of wiping the lesions especially in areas associated with hyperesthesia and helps in reinforcing the diagnosis. However, the criteria to diagnose DN based on dermoscopy is not definite.
背景:疏忽性皮肤病(DN)是一种未确诊的局部色素紊乱,其特征是在未充分清洁的区域出现无症状的色素沉着斑块和斑块,并伴有粘附的鳞片。这是一项诊断挑战,导致不必要的干预和患者负担。皮肤镜检查是一种无创的方便的诊断工具,虽然它在诊断DN的效用尚未探索。目的:探讨DN患者的临床及皮肤镜表现。材料与方法:对某三级医院收治的10例DN患者进行观察性研究,这些患者因色素沉着病变就诊于皮肤科。在详细的病史和临床检查后,对病变进行皮肤镜检查。结果:10例患者经水浸纱布处理,部分病变消退,确诊DN。皮肤镜下,深棕色多边形玉米片状鳞片呈马赛克状排列,其间有正常皮肤,有时在红斑背景上。进一步探查后,大多数患者都有无意中忽视与其原发疾病相关的受影响部位的病史。局限性:样本量小。结论:DN是一种未被报道的局部性色素沉着症,类似于其他皮肤病。对于那些发病导致相关区域无法保持卫生的患者,这可能不是DN的经典描述部位,应该始终牢记。皮肤镜检查有助于将其与其他色素沉着的病变区分开来,特别是在其较温和的形式下,避免擦拭病变,特别是在与感觉亢进有关的区域,并有助于加强诊断。然而,基于皮肤镜诊断DN的标准尚不明确。
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引用次数: 0
Pigmented epithelioid melanocytoma: A clinico-histopathological enigma 色素上皮样黑素细胞瘤:一个临床组织病理学谜团
Pub Date : 2022-07-01 DOI: 10.4103/ijdpdd.ijdpdd_32_22
P. Shah, Raju G. Chaudhary, Ashish Jagati, Kalgi D. Baxi
Blue nevi are a group of congenital or acquired benign dermal melanocytic tumors. Various clinical and histological variants have been described.Epithelioid blue nevus (EBN), an uncommon variant may present as blue gray nodule over trunk, extremities which might occur either sporadically or in association with Carney complex. Due to clinical and histological overlap with other pigmented melanocytic lesions clinicopathological correlation is essential. We report a case of epithelioid blue nevus on dorsum of right foot in a 22-year-old man.
蓝痣是一组先天性或获得性良性皮肤黑色素细胞肿瘤。各种临床和组织学变异已被描述。上皮样蓝痣(EBN)是一种罕见的变体,可表现为躯干和四肢上的蓝灰色结节,可能偶尔发生或与卡尼复合体有关。由于临床和组织学重叠与其他色素黑素细胞病变的临床病理相关性是必不可少的。我们报告一个22岁男性右脚背上皮样蓝色痣的病例。
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引用次数: 0
Clinico-dermatoscopic and histopathological evaluation of a case of generalized lichen nitidus 广泛性地衣1例临床皮镜及组织病理学分析
Pub Date : 2022-07-01 DOI: 10.4103/ijdpdd.ijdpdd_57_21
S. Mahajan, Surender Singh, Yallappa Kabbannavar, V. Kharkar
Lichen nitidus (LN) is a rare asymptomatic skin disease composed of numerous tiny, shiny, flat papules mainly over the chest, forehead, neck, forearm, and glans penis. They are of two types based on distribution, localized which is more common compared to generalized. Dermoscopy helps in differentiating LN from other similar dermatoses such as lichen planus, keratosis pilaris, follicular eczema, lichen spinulosus, which is non-invasive. We describe a 15-year-old female with generalized lichen nitidus with palms, soles, and nail involvement with dermoscopic features and histopathological correlation.
黑斑地衣(LN)是一种罕见的无症状皮肤病,由许多细小、有光泽的扁平丘疹组成,主要分布在胸部、前额、颈部、前臂和阴茎头。它们有两种基于分布的类型,局部分布比广义分布更常见。皮肤镜检查有助于区分LN与其他类似的皮肤病,如扁平苔藓、毛毛角化病、毛囊性湿疹、棘状苔藓,这是无创的。我们描述了一个15岁的女性广泛性地衣nitidus与手掌,鞋底和指甲累及皮肤镜特征和组织病理学的相关性。
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引用次数: 0
A rare case of purely cutaneous Rosai–Dorfman’s disease: Xanthoma-like presentation 一例罕见的纯皮肤Rosai-Dorfman病:黄瘤样表现
Pub Date : 2022-01-01 DOI: 10.4103/ijdpdd.ijdpdd_37_21
Sushanti Jadhav, A. Dongre, B. Darkase, Ameet L. Dandale
Rosai–Dorfman’s disease (RDD) is sinus histiocytosis with massive lymphadenopathy. Cutaneous RDD is a rare entity that presents with isolated skin involvement without any systemic involvement. We report a 35-year-old man with an asymptomatic large nodule on the preauricular region of the face with an irregular surface and multiple yellow studded nodules. On detailed physical and systemic examination, there was no lymph node or systemic involvement. Skin biopsy on histopathology showed dense dermal inflammatory infiltrate and foamy histiocytes with emperipolesis. Immunohistochemical markers were positive for S100 protein and CD68 protein but negative for CD1a. Thus, a diagnosis of cutaneous RDD was made.
Rosai-Dorfman病(RDD)是一种窦性组织细胞增生伴大量淋巴结病。皮肤RDD是一个罕见的实体,表现为孤立的皮肤受累而没有任何全身受累。我们报告一个35岁的男性,在脸的耳前区域有一个无症状的大结节,表面不规则,并有多个黄色点缀的结节。详细的体格和全身检查,没有淋巴结或全身受累。皮肤组织病理活检显示真皮炎症浸润,组织细胞呈泡沫状,并伴有表皮增生。免疫组化标记S100蛋白和CD68蛋白阳性,CD1a蛋白阴性。因此,诊断为皮肤RDD。
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引用次数: 0
Habit tic deformity of bilateral thumbnails: A dermoscopic view 双侧拇指指甲习惯性畸形:皮肤镜观察
Pub Date : 2022-01-01 DOI: 10.4103/ijdpdd.ijdpdd_78_21
Anmol Bhargava, S. Mahajan
Nail examination is an important aspect of a wholistic dermatological examination, which when overlooked leads to missing out on important and interesting relevant findings. We observed one such typical interesting finding in a patient who presented to the out patient department with characteristic nail changes suggestive of habit tic type of onychotillomania as an incidental finding. Further, dermoscopy of the affected nails showed characteristic features of the same.
指甲检查是整体皮肤科检查的一个重要方面,当忽视导致错过重要和有趣的相关发现。我们观察到一个这样一个典型的有趣的发现在病人谁提出了门诊部的特征性指甲变化暗示习惯类型的躁狂作为偶然发现。此外,受影响的指甲皮肤镜检查显示相同的特征。
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引用次数: 0
Dermoscopy of cutaneous and palmar lichen nitidus 皮肤及手掌地衣的皮肤镜检查
Pub Date : 2022-01-01 DOI: 10.4103/ijdpdd.ijdpdd_128_20
J. Dave, S. Mahajan, Prateek Oswal
Lichen nitidus (LN) is a relatively uncommon chronic cutaneous lichenoid group of disease characterized by tiny quintessentially discrete hypopigmented to skin coloured papules commonly seen over dorsa of hands/forearms, lower abdomen, penis, and buttocks. The cutaneous manifestation of a disease on palms/soles varies from their presentation on body, which makes it difficult to diagnose at times. A 23-year-old healthy female presented with mildly itchy lesions on bilateral wrist, fingers, elbows, peri-umbilical area, and left palm since 6 months. On dermoscopy, we could appreciate the classical described findings of LN which were confirmed on histopathology. LN has a characteristic dermoscopic features, which come to rescue for diagnosis and also avoid a biopsy. We describe a rare presentation of palmar LN with two different morphologies along with classical cutaneous distribution of LN and their dermoscopy.
nitius Lichen nitius (LN)是一种相对罕见的慢性皮肤类地衣组疾病,其特征是微小的典型的分散的低色素到皮肤颜色的丘疹,常见于手/前臂背、下腹、阴茎和臀部。一种疾病在手掌/脚底的皮肤表现与它们在身体上的表现不同,这使得有时难以诊断。23岁健康女性,6个月来出现双侧手腕、手指、肘部、脐周区域和左手掌轻度发痒病变。在皮肤镜下,我们可以欣赏LN的经典描述结果,并在组织病理学上得到证实。LN具有独特的皮肤镜特征,这有助于诊断,也避免了活检。我们描述了一个罕见的掌部LN的两种不同的形态,以及LN的经典皮肤分布和他们的皮肤镜检查。
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引用次数: 1
Plexiform schwannoma at an unusual site involving the angle of mouth: Report of a rare case 不寻常部位的丛状神经鞘瘤累及口角:报告一例罕见病例
Pub Date : 2022-01-01 DOI: 10.4103/ijdpdd.ijdpdd_17_21
Navakumar Manickam, Kannan Gopalan, Ann Nisha, A. Kulandaivel
Plexiform schwannoma (PS) is a rare benign encapsulated peripheral nerve sheath tumor characterized by a plexiform pattern of intraneural growth often with a multinodular appearance. It usually presents as a solitary mass with a strong predilection for young adults between 20 and 50 years. Despite its common presentation in the head and neck region, involvement of the lip is extremely rare. Multiple cutaneous PSs are commonly associated with Neurofibromatosis type 2 or Schwannomatosis. To date, only a few cases of PS involving the lip have been reported. Here in we report another unusual case of PS involving the angle of mouth which was removed completely by surgical excision without any recurrence seen at 1-year post-surgery.
丛状神经鞘瘤(PS)是一种罕见的良性周围神经鞘包膜瘤,其特征是神经内呈丛状生长,常呈多结节状。它通常表现为一个孤立的肿块,强烈倾向于20至50岁的年轻人。尽管它的常见表现在头部和颈部区域,嘴唇的参与是极其罕见的。多发性皮肤PSs通常与2型神经纤维瘤病或神经鞘瘤病有关。到目前为止,只有少数涉及嘴唇的PS病例被报道。在这里,我们报告了另一个不寻常的PS病例,涉及口角,手术切除完全去除,术后1年无复发。
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引用次数: 0
Dermoscopy of angioma serpiginosum 蛇形血管瘤的皮肤镜检查
Pub Date : 2022-01-01 DOI: 10.4103/ijdpdd.ijdpdd_74_21
S. Mahajan, Yallappa Kabbannavar, T. Vishwanath, Surender Singh
{"title":"Dermoscopy of angioma serpiginosum","authors":"S. Mahajan, Yallappa Kabbannavar, T. Vishwanath, Surender Singh","doi":"10.4103/ijdpdd.ijdpdd_74_21","DOIUrl":"https://doi.org/10.4103/ijdpdd.ijdpdd_74_21","url":null,"abstract":"","PeriodicalId":423971,"journal":{"name":"Indian Journal of Dermatopathology and Diagnostic Dermatology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117142034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Indian Journal of Dermatopathology and Diagnostic Dermatology
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