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A Medicinal Potential worth of Caesalpinia bonducella 山葵的药用价值
Pub Date : 2023-01-20 DOI: 10.36348/merjps.2023.v03i01.001
G. Singh, Sunil Kumar, J. Malik
The welfare of people all around the world is shaped in large part by herbal remedies. In medicine, healing plants are used to treat ailments that affect a person as well as a potential way to keep them healthy. One of the pans tropical leguminous scandent plants, Caesalpinia bonduc is thought to have scientific uses by many researchers and has been used as a source of medicine by locals for a very long time. The Caesalpiniaceae genus is wellorganized, including Caesalpinia bonducella. Then, it is referred to as C. crista Linn and C. bonducella Flem. Common names for it include Fever Nut, Bonduc Nut, and Nicker Nut. The plant is available in the tropical countries of Bangladesh, Sri Lanka, Myanmar, Vietnam, and China. Every major chemical component of the Caesalpinia bonduc plant is present, including isoflavones, steroidal saponin, fatty acids, hydrocarbons, amino acids, phenolics, and phytosterols. The objective of the current study oversimplifies the chemical components and pharmacological and therapeutic uses of Caesalpinia bonduc. © Copyright 2023 Kuwait Scholars Publisher. All Rights Reserved.
世界各地人民的福祉在很大程度上取决于草药疗法。在医学上,治疗植物被用来治疗影响人的疾病,以及一种保持健康的潜在方法。作为一种热带豆科植物,许多研究人员认为它具有科学用途,并且在很长一段时间内被当地人用作药物来源。该科植物组织良好,包括bonducella。然后,它被称为C. crista Linn和C. bonducella Flem。它的常见名称包括热坚果、邦杜克坚果和尼克坚果。这种植物在孟加拉国、斯里兰卡、缅甸、越南和中国等热带国家都能买到。该植物的所有主要化学成分都存在,包括异黄酮、甾体皂苷、脂肪酸、碳氢化合物、氨基酸、酚类物质和植物甾醇。目前研究的目的过于简化的化学成分和药理学和治疗用途的凯撒宾。©版权所有2023科威特学者出版社。版权所有。
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引用次数: 0
Hepatoprotective Potential of Caesalpinia bonducella: Molecular Insight bonducella Caesalpinia的保肝潜能:分子观察
Pub Date : 2022-06-01 DOI: 10.36348/merjps.2022.v02i01.004
M. Bhatt, J. Malik
Abstract: Liver fibrosis is a wound healing process initiated in response to chronic liver damage caused by viruses, toxins, and hepatotoxic drugs. The disease is characterized by inflammation followed by deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) has been identified as a host cofactor for hepatitis C virus (HCV) entry. The plant Caesalpinia bonducella is used in a variety of systems a traditional medicine used to treat human ailments and affiliation prickly shrub belonging to the Caesalpiniaceae family found throughout the world, especially tropical region. It is a very valuable medicinal plant because all parts of the plant have medicinal properties. It was like traditional Indian herbal medicine considered an important therapeutic modality for the treatment of various diseases. As per literature survey the plants containing kaempferol and quercetin-3-methylether are traditionally utilized for the cure of cancer and liver related disorders from the immortal time. The exact mechanism of action for the hepatoprotective action of kaempferol and quercetin-3-methylether was still not revealed. With intent to propose the most probable mechanism of action of kaempferol and quercetin-3-methylether the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.
摘要:肝纤维化是由病毒、毒素和肝毒性药物引起的慢性肝损伤引起的伤口愈合过程。这种疾病的特征是炎症,然后是细胞外基质蛋白沉积形成疤痕组织。Ephrin受体A2 (EphA2)已被确定为丙型肝炎病毒(HCV)进入宿主的辅助因子。植物Caesalpinia bonducella被用于各种系统,一种用于治疗人类疾病的传统药物和隶属于caesalpinaceae家族的多刺灌木,分布在世界各地,特别是热带地区。它是一种非常有价值的药用植物,因为它的所有部分都具有药用价值。就像传统的印度草药被认为是治疗各种疾病的重要治疗方式。根据文献调查,山奈酚和槲皮素-3-甲基醚的植物从古代起就被传统地用于治疗癌症和肝脏相关疾病。山奈酚和槲皮素-3-甲基醚的保肝作用机制尚未明确。为了提出山奈酚和槲皮素-3-甲基醚最可能的作用机制,我们对PPARα酶等肝保护药物靶点进行了对接计算分析。
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引用次数: 0
Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach 利奈唑胺作为SARS-CoV-2 Nsp13解旋酶的有效抑制剂:基于网格的对接方法
Pub Date : 2022-05-27 DOI: 10.36348/merjps.2022.v02i01.003
N. Singh, J. Malik
Abstract: A diversified originator in humans and wildlife, the corona virus (COVID-19) is an enveloped RNA virus. Six different species have been shown to be the root of human sickness. Human diseases are greatly influenced by viral infections, and one of the most recent global epidemics is the appearance of the new corona. The SARS (Severe Acute Respiratory Syndrome) virus, a potentially fatal viral infection, was caused by the SS-RNA virus from the enveloped corona virus family. In many nations around the world, disease is rapidly expanding. 462,684 confirmed cases and 20,834 fatalities had been reported as of March 26, 2020, internationally. On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). There are numerous medication trials ongoing, and some of the outcomes are encouraging. However, since there is no vaccine, the only approach to fight the virus is through preventative measures. Patients with bacterial nosocomial pneumonia were successfully treated with the antibiotic "Linezolid" by receiving an intravenous dose of 600 mg of linezolid every 12 hours for 7 to 10 days. All of the patients made a full recovery and were allowed to leave the hospital. Additionally, previous studies have shown that linezolid is more clinically and microbiologically effective than other antibiotics (vancomycin). The goal of the current study was to use a molecular docking approach to evaluate linezolid's potential against SAR-CoV-2 infection.
摘要:冠状病毒(COVID-19)是一种包膜RNA病毒,起源于人类和野生动物。六种不同的物种被证明是人类疾病的根源。人类疾病受到病毒感染的极大影响,最近的全球流行病之一是新冠病毒的出现。SARS(严重急性呼吸系统综合症)病毒是一种潜在的致命病毒感染,由包膜冠状病毒科的SS-RNA病毒引起。在世界上许多国家,疾病正在迅速蔓延。截至2020年3月26日,全球共报告确诊病例462684例,死亡病例20834例。2020年3月11日,世界卫生组织宣布新冠肺炎疫情为大流行。目前正在进行大量的药物试验,其中一些结果令人鼓舞。然而,由于没有疫苗,对抗病毒的唯一方法是通过预防措施。细菌性院内肺炎患者通过每12小时静脉注射600毫克利奈唑胺,连续7至10天,成功地治疗了抗生素“利奈唑胺”。所有的病人都完全康复并获准出院。此外,先前的研究表明,利奈唑胺比其他抗生素(万古霉素)在临床和微生物学上更有效。本研究的目的是使用分子对接方法评估利奈唑胺对抗sars - cov -2感染的潜力。
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引用次数: 0
In-Silico Consideration of Anti-Microbial Prospective of Plant Phenolic and Flavonoids 植物酚类和黄酮类化合物抑菌前景的计算机模拟研究
Pub Date : 2022-02-28 DOI: 10.36348/merjps.2022.v02i01.001
Amit Kumar, J. Malik
Abstract: Background: Pathogenic microorganism infections pose a serious threat to human health. The need for innovative, safe, and efficient antimicrobial medicines has been driven by rising drug resistance cases, unfavorable antibiotic side effects, and the reemergence of previously identified illnesses. Virtual screening techniques used in drug development, such as drug-likeness and ADMET analysis, use computation to quickly and cheaply identify compounds that are likely to demonstrate physiological activity. Methods: In this regard, the enzyme aminoacyl-tRNA synthetase (AaRS) has been the focus of recent research in the discovery of antibacterial agents. Docking studies were performed Molecular docking of aminoacyl-tRNA synthetase (AaRS) with chlorogenic acid, rutin, quercetin and gallic acid was carried out by AutoDock. Results: The molecular docking result revealed that chlorogenic acid, gallic acid, quercetin and rutin showed encouraging docking score. Hence from above finding it can be predicted that phenolics and flavonoids found in the plants extract exhibited good inhibitor of IleRS enzyme.
摘要:背景:病原微生物感染对人类健康构成严重威胁。不断增加的耐药性病例、不利的抗生素副作用以及以前发现的疾病的重新出现,推动了对创新、安全和有效的抗菌药物的需求。用于药物开发的虚拟筛选技术,如药物相似性和ADMET分析,使用计算来快速和廉价地识别可能表现出生理活性的化合物。方法:在这方面,氨基酰基trna合成酶(AaRS)是近年来发现抗菌剂的研究热点。利用AutoDock软件对氨基酰基trna合成酶(AaRS)与绿原酸、芦丁、槲皮素和没食子酸进行分子对接。结果:分子对接结果显示绿原酸、没食子酸、槲皮素和芦丁的对接评分较高。由此可以预测,植物提取物中的酚类物质和黄酮类物质具有较好的抑酶作用。
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引用次数: 0
Formulation and Evaluation of Controlled Release Matrix Tablets of Cefixime Trihydrate 三水合头孢克肟控释基质片的研制与评价
Pub Date : 2021-12-30 DOI: 10.36348/merjps.2021.v01i01.005
Rashmi Shivaji Tambare, G. Tapadiya, S. Shahi
Abstract: The main objective of the present work was to develop sustained release matrix tablets of Cefixime Trihydrate were prepared by direct compression techniques and evaluates the effect of formulation variables such as lubricant, binder, polymer content and viscosity grades of HPMC on the behavior of Cefixime Trihydrate release. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check to evaluate the sustained release matrix tablet of Cefixime Trihydrate. The drug release from the optimized formulation was found to follow zero order kinetics. Thus the phenomenon of drug release showed that the release of optimized formulation is controlled by diffusion. Administration of Cefixime Trihydrate in a sustained release dosage would be more desirable for bacterial infections effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From In vitro dissolution profile, Formulation S3 was prepared with Hydroxypropyl methylcellulose (K15M) combination where drug release was about 99.14% at the end of 24 hrs and followed zero order with non-Fickian diffusion method. It is selected as the best formulation.
摘要:采用直接压缩法制备三水合头孢克肟缓释片,考察润滑剂、黏合剂、聚合物含量、HPMC黏度等因素对三水合头孢克肟缓释片的影响。对所制片剂进行了理化参数评价。考察三水合头孢克肟缓释基质片的体外释放特性。优化后的药物释放符合零级动力学。因此,药物释放现象表明,优化制剂的释放受扩散控制。通过维持药物的血浆浓度远高于治疗浓度,以缓释剂量施用三水合头孢克肟对细菌感染的影响更可取。从体外溶出度曲线看,制剂S3为羟丙基甲基纤维素(K15M)复合制剂,24 h后释药率为99.14%,非菲克扩散法释药顺序为零。它被选为最佳配方。
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引用次数: 0
Mechanistic Insight Hypolipidemic Potential of Ascorbic Acid: In-Silico Molecular Docking 抗坏血酸降血脂的机制:硅分子对接
Pub Date : 2021-12-28 DOI: 10.36348/merjps.2021.v01i01.001
M. Yadav, J. Malik
Abstract: Ascorbic acid, also known as vitamin C, is a crucial part of a balanced diet. The history of vitamin C is intertwined with that of the human ailment scurvy, which was perhaps the first to be identified as a deficiency condition in humans. Its signs include diarrhoea, overall weakness, severe bleeding of the tissues and gums, and tiredness. Ascorbic acid is a water-soluble chemical molecule essential to numerous biological functions. The exact mechanism of action for the lipid lowering action of ascorbic acid was still not revealed. With intent to propose the most probable mechanism of action of ascorbic acid the docking based computational analysis has been performed against the lipid lowering drug targets like ATP citrate lyase enzyme, lanosterol 14α-demethylase enzyme, squalene synthase enzyme, and Niemann Pick C1 like Protein. The docking analysis, chemical interactions, followed by the physicochemical based pharmacokinetic profiling has revealed that the ascorbic acid is executing its lipid lowering action via inhibiting the squalene synthase enzyme.
摘要:抗坏血酸又称维生素C,是均衡饮食的重要组成部分。维生素C的历史与人类坏血病的历史交织在一起,坏血病可能是第一个被确定为人类缺乏维生素C的疾病。其症状包括腹泻、全身虚弱、组织和牙龈严重出血以及疲劳。抗坏血酸是一种水溶性化学分子,对许多生物功能至关重要。抗坏血酸降脂作用的确切机制尚不清楚。为了提出抗坏血酸最可能的作用机制,我们对ATP柠檬酸裂解酶、羊毛甾醇14α-去甲基化酶、角鲨烯合成酶、Niemann Pick C1 like Protein等降脂药物靶点进行了对接计算分析。对接分析、化学相互作用以及基于物理化学的药代动力学分析表明,抗坏血酸是通过抑制角鲨烯合成酶来发挥其降脂作用的。
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引用次数: 0
Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach 绿原酸是一种有效的抗炎剂:硅分子对接方法
Pub Date : 2021-12-27 DOI: 10.36348/merjps.2022.v02i01.002
Shayara Bano, J. Malik
Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.
摘要:绿原酸(5- o -咖啡酰奎宁酸)是羟基肉桂酸家族的酚类化合物。这种多酚具有许多增强健康的特性,其中大多数与代谢综合征的治疗有关,包括抗氧化、抗炎、降脂、抗糖尿病和降压作用。此外,绿原酸具有抗氧化特性,特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外,绿原酸具有抗氧化特性,特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外,绿原酸具有抗氧化特性,特别是抗脂质氧化。防止食物中其他生物活性化合物降解的保护特性和益生元活性。方法:采用AutoDock技术将COX2、NF-κB诱导激酶(NIK)和磷脂酶a2 (PLA2)与绿原酸进行分子对接。结果:分子对接结果显示绿原酸具有较高的对接评分。对接分数分别为-6.71、-6.31和-4.43 kcal mol-1。
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引用次数: 0
Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine 水杨醛和二苯胺合成的Co (II)和Cu (II)席夫碱配合物的抑菌和抑菌活性研究
Pub Date : 2021-12-27 DOI: 10.36348/merjps.2021.v01i01.003
U. B., M. C., Uba A, Muhammad A. A
Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.
摘要:本文报道了希夫碱及其由水杨醛和二苯胺衍生的金属(II)配合物(Co, Cu)的抑菌和抑菌活性。利用红外光谱(FTIR)、熔点、溶解度和摩尔电导等分析技术对希夫碱及其金属配合物进行了表征,并对希夫碱及其金属配合物进行了着色。红外光谱分析结果显示,在1614cm-1处有亚甲基(C=N)形成,证实了席夫碱的形成。在664cm-1处的条带表示配合物的形成,该配合物为V(M-N),支持希夫碱与相应金属的配位。溶解度测试结果表明,希夫碱和配合物均可溶于大多数有机溶剂,不溶于水。希夫碱和配合物的熔点和分解温度都很高。配合物在二甲基亚砜(DMSO)中的摩尔电导数据显示为9和10欧姆-1cm2 mol-1的低值,表明配合物是非电解质。对所有化合物的抗菌和抗真菌活性进行了测试。结果表明,这些化合物对被试生物的生长有抑制作用。
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引用次数: 0
Mechanistic Insight Antidiabetic Potential of Ursolic Acid: In-Silico Molecular Docking 熊果酸抗糖尿病潜能的机理:硅基分子对接
Pub Date : 2021-12-27 DOI: 10.36348/merjps.2021.v01i01.002
Priyanka Ahirwar, J. Malik
Abstract: Diabetes mellitus is a chief cause involved in the morbidity and mortality among the global population (Steppan et al., 2001). The main event of this syndrome includes elevated blood glucose level (hyperglycemia) followed by polydipsia and polyuria. The secondary complications include retinal damage, loss of kidney function and damage to nerves. Further, the diabetes mellitus will also increase the cardiovascular disease progression. Pentacyclictriterpenes are as well one of the compounds occurring in plants. In this group Ursolic acid is a well-recognized compound that is accessible from various sources like seeds as well as fruits and possess many types of activities and is a bright contender for developing novel treatment approaches for treating diseases. Thus, in the current study, ursolic acid a triterpenoid was selected for evaluation of antidiabetic potential by molecular docking. A mechanistic insight for their antidiabetic potential is elucidating by interaction of ursolic acid with target proteins.
摘要:糖尿病是全球人群发病和死亡的主要原因之一(Steppan et al., 2001)。该综合征的主要事件包括血糖水平升高(高血糖),随后是多饮和多尿。继发性并发症包括视网膜损伤、肾功能丧失和神经损伤。此外,糖尿病还会增加心血管疾病的进展。五环三萜也是植物中存在的化合物之一。在这一组中,熊果酸是一种公认的化合物,可以从种子和水果等各种来源获得,具有多种类型的活性,是开发治疗疾病的新方法的有力竞争者。因此,在本研究中,我们选择熊果酸-三萜,通过分子对接来评价其抗糖尿病潜能。熊果酸与靶蛋白的相互作用阐明了其抗糖尿病潜能的机制。
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引用次数: 0
期刊
Middle East Research Journal of Pharmaceutical Sciences
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