Pub Date : 2022-06-01DOI: 10.36348/merjps.2022.v02i01.004
M. Bhatt, J. Malik
Abstract: Liver fibrosis is a wound healing process initiated in response to chronic liver damage caused by viruses, toxins, and hepatotoxic drugs. The disease is characterized by inflammation followed by deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) has been identified as a host cofactor for hepatitis C virus (HCV) entry. The plant Caesalpinia bonducella is used in a variety of systems a traditional medicine used to treat human ailments and affiliation prickly shrub belonging to the Caesalpiniaceae family found throughout the world, especially tropical region. It is a very valuable medicinal plant because all parts of the plant have medicinal properties. It was like traditional Indian herbal medicine considered an important therapeutic modality for the treatment of various diseases. As per literature survey the plants containing kaempferol and quercetin-3-methylether are traditionally utilized for the cure of cancer and liver related disorders from the immortal time. The exact mechanism of action for the hepatoprotective action of kaempferol and quercetin-3-methylether was still not revealed. With intent to propose the most probable mechanism of action of kaempferol and quercetin-3-methylether the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.
{"title":"Hepatoprotective Potential of Caesalpinia bonducella: Molecular Insight","authors":"M. Bhatt, J. Malik","doi":"10.36348/merjps.2022.v02i01.004","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.004","url":null,"abstract":"Abstract: Liver fibrosis is a wound healing process initiated in response to chronic liver damage caused by viruses, toxins, and hepatotoxic drugs. The disease is characterized by inflammation followed by deposition of extracellular matrix proteins to form scar tissue. Ephrin receptor A2 (EphA2) has been identified as a host cofactor for hepatitis C virus (HCV) entry. The plant Caesalpinia bonducella is used in a variety of systems a traditional medicine used to treat human ailments and affiliation prickly shrub belonging to the Caesalpiniaceae family found throughout the world, especially tropical region. It is a very valuable medicinal plant because all parts of the plant have medicinal properties. It was like traditional Indian herbal medicine considered an important therapeutic modality for the treatment of various diseases. As per literature survey the plants containing kaempferol and quercetin-3-methylether are traditionally utilized for the cure of cancer and liver related disorders from the immortal time. The exact mechanism of action for the hepatoprotective action of kaempferol and quercetin-3-methylether was still not revealed. With intent to propose the most probable mechanism of action of kaempferol and quercetin-3-methylether the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"2675 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124154784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-27DOI: 10.36348/merjps.2022.v02i01.003
N. Singh, J. Malik
Abstract: A diversified originator in humans and wildlife, the corona virus (COVID-19) is an enveloped RNA virus. Six different species have been shown to be the root of human sickness. Human diseases are greatly influenced by viral infections, and one of the most recent global epidemics is the appearance of the new corona. The SARS (Severe Acute Respiratory Syndrome) virus, a potentially fatal viral infection, was caused by the SS-RNA virus from the enveloped corona virus family. In many nations around the world, disease is rapidly expanding. 462,684 confirmed cases and 20,834 fatalities had been reported as of March 26, 2020, internationally. On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). There are numerous medication trials ongoing, and some of the outcomes are encouraging. However, since there is no vaccine, the only approach to fight the virus is through preventative measures. Patients with bacterial nosocomial pneumonia were successfully treated with the antibiotic "Linezolid" by receiving an intravenous dose of 600 mg of linezolid every 12 hours for 7 to 10 days. All of the patients made a full recovery and were allowed to leave the hospital. Additionally, previous studies have shown that linezolid is more clinically and microbiologically effective than other antibiotics (vancomycin). The goal of the current study was to use a molecular docking approach to evaluate linezolid's potential against SAR-CoV-2 infection.
{"title":"Linezolid as Potent Inhibitor of SARS-CoV-2 Nsp13 Helicase: Grid Based Docking Approach","authors":"N. Singh, J. Malik","doi":"10.36348/merjps.2022.v02i01.003","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.003","url":null,"abstract":"Abstract: A diversified originator in humans and wildlife, the corona virus (COVID-19) is an enveloped RNA virus. Six different species have been shown to be the root of human sickness. Human diseases are greatly influenced by viral infections, and one of the most recent global epidemics is the appearance of the new corona. The SARS (Severe Acute Respiratory Syndrome) virus, a potentially fatal viral infection, was caused by the SS-RNA virus from the enveloped corona virus family. In many nations around the world, disease is rapidly expanding. 462,684 confirmed cases and 20,834 fatalities had been reported as of March 26, 2020, internationally. On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization (WHO). There are numerous medication trials ongoing, and some of the outcomes are encouraging. However, since there is no vaccine, the only approach to fight the virus is through preventative measures. Patients with bacterial nosocomial pneumonia were successfully treated with the antibiotic \"Linezolid\" by receiving an intravenous dose of 600 mg of linezolid every 12 hours for 7 to 10 days. All of the patients made a full recovery and were allowed to leave the hospital. Additionally, previous studies have shown that linezolid is more clinically and microbiologically effective than other antibiotics (vancomycin). The goal of the current study was to use a molecular docking approach to evaluate linezolid's potential against SAR-CoV-2 infection.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122896536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.36348/merjps.2022.v02i01.001
Amit Kumar, J. Malik
Abstract: Background: Pathogenic microorganism infections pose a serious threat to human health. The need for innovative, safe, and efficient antimicrobial medicines has been driven by rising drug resistance cases, unfavorable antibiotic side effects, and the reemergence of previously identified illnesses. Virtual screening techniques used in drug development, such as drug-likeness and ADMET analysis, use computation to quickly and cheaply identify compounds that are likely to demonstrate physiological activity. Methods: In this regard, the enzyme aminoacyl-tRNA synthetase (AaRS) has been the focus of recent research in the discovery of antibacterial agents. Docking studies were performed Molecular docking of aminoacyl-tRNA synthetase (AaRS) with chlorogenic acid, rutin, quercetin and gallic acid was carried out by AutoDock. Results: The molecular docking result revealed that chlorogenic acid, gallic acid, quercetin and rutin showed encouraging docking score. Hence from above finding it can be predicted that phenolics and flavonoids found in the plants extract exhibited good inhibitor of IleRS enzyme.
{"title":"In-Silico Consideration of Anti-Microbial Prospective of Plant Phenolic and Flavonoids","authors":"Amit Kumar, J. Malik","doi":"10.36348/merjps.2022.v02i01.001","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.001","url":null,"abstract":"Abstract: Background: Pathogenic microorganism infections pose a serious threat to human health. The need for innovative, safe, and efficient antimicrobial medicines has been driven by rising drug resistance cases, unfavorable antibiotic side effects, and the reemergence of previously identified illnesses. Virtual screening techniques used in drug development, such as drug-likeness and ADMET analysis, use computation to quickly and cheaply identify compounds that are likely to demonstrate physiological activity. Methods: In this regard, the enzyme aminoacyl-tRNA synthetase (AaRS) has been the focus of recent research in the discovery of antibacterial agents. Docking studies were performed Molecular docking of aminoacyl-tRNA synthetase (AaRS) with chlorogenic acid, rutin, quercetin and gallic acid was carried out by AutoDock. Results: The molecular docking result revealed that chlorogenic acid, gallic acid, quercetin and rutin showed encouraging docking score. Hence from above finding it can be predicted that phenolics and flavonoids found in the plants extract exhibited good inhibitor of IleRS enzyme.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116014557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.36348/merjps.2021.v01i01.005
Rashmi Shivaji Tambare, G. Tapadiya, S. Shahi
Abstract: The main objective of the present work was to develop sustained release matrix tablets of Cefixime Trihydrate were prepared by direct compression techniques and evaluates the effect of formulation variables such as lubricant, binder, polymer content and viscosity grades of HPMC on the behavior of Cefixime Trihydrate release. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check to evaluate the sustained release matrix tablet of Cefixime Trihydrate. The drug release from the optimized formulation was found to follow zero order kinetics. Thus the phenomenon of drug release showed that the release of optimized formulation is controlled by diffusion. Administration of Cefixime Trihydrate in a sustained release dosage would be more desirable for bacterial infections effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From In vitro dissolution profile, Formulation S3 was prepared with Hydroxypropyl methylcellulose (K15M) combination where drug release was about 99.14% at the end of 24 hrs and followed zero order with non-Fickian diffusion method. It is selected as the best formulation.
{"title":"Formulation and Evaluation of Controlled Release Matrix Tablets of Cefixime Trihydrate","authors":"Rashmi Shivaji Tambare, G. Tapadiya, S. Shahi","doi":"10.36348/merjps.2021.v01i01.005","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.005","url":null,"abstract":"Abstract: The main objective of the present work was to develop sustained release matrix tablets of Cefixime Trihydrate were prepared by direct compression techniques and evaluates the effect of formulation variables such as lubricant, binder, polymer content and viscosity grades of HPMC on the behavior of Cefixime Trihydrate release. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check to evaluate the sustained release matrix tablet of Cefixime Trihydrate. The drug release from the optimized formulation was found to follow zero order kinetics. Thus the phenomenon of drug release showed that the release of optimized formulation is controlled by diffusion. Administration of Cefixime Trihydrate in a sustained release dosage would be more desirable for bacterial infections effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From In vitro dissolution profile, Formulation S3 was prepared with Hydroxypropyl methylcellulose (K15M) combination where drug release was about 99.14% at the end of 24 hrs and followed zero order with non-Fickian diffusion method. It is selected as the best formulation.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121074417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-28DOI: 10.36348/merjps.2021.v01i01.001
M. Yadav, J. Malik
Abstract: Ascorbic acid, also known as vitamin C, is a crucial part of a balanced diet. The history of vitamin C is intertwined with that of the human ailment scurvy, which was perhaps the first to be identified as a deficiency condition in humans. Its signs include diarrhoea, overall weakness, severe bleeding of the tissues and gums, and tiredness. Ascorbic acid is a water-soluble chemical molecule essential to numerous biological functions. The exact mechanism of action for the lipid lowering action of ascorbic acid was still not revealed. With intent to propose the most probable mechanism of action of ascorbic acid the docking based computational analysis has been performed against the lipid lowering drug targets like ATP citrate lyase enzyme, lanosterol 14α-demethylase enzyme, squalene synthase enzyme, and Niemann Pick C1 like Protein. The docking analysis, chemical interactions, followed by the physicochemical based pharmacokinetic profiling has revealed that the ascorbic acid is executing its lipid lowering action via inhibiting the squalene synthase enzyme.
摘要:抗坏血酸又称维生素C，是均衡饮食的重要组成部分。维生素C的历史与人类坏血病的历史交织在一起，坏血病可能是第一个被确定为人类缺乏维生素C的疾病。其症状包括腹泻、全身虚弱、组织和牙龈严重出血以及疲劳。抗坏血酸是一种水溶性化学分子，对许多生物功能至关重要。抗坏血酸降脂作用的确切机制尚不清楚。为了提出抗坏血酸最可能的作用机制，我们对ATP柠檬酸裂解酶、羊毛甾醇14α-去甲基化酶、角鲨烯合成酶、Niemann Pick C1 like Protein等降脂药物靶点进行了对接计算分析。对接分析、化学相互作用以及基于物理化学的药代动力学分析表明，抗坏血酸是通过抑制角鲨烯合成酶来发挥其降脂作用的。
{"title":"Mechanistic Insight Hypolipidemic Potential of Ascorbic Acid: In-Silico Molecular Docking","authors":"M. Yadav, J. Malik","doi":"10.36348/merjps.2021.v01i01.001","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.001","url":null,"abstract":"Abstract: Ascorbic acid, also known as vitamin C, is a crucial part of a balanced diet. The history of vitamin C is intertwined with that of the human ailment scurvy, which was perhaps the first to be identified as a deficiency condition in humans. Its signs include diarrhoea, overall weakness, severe bleeding of the tissues and gums, and tiredness. Ascorbic acid is a water-soluble chemical molecule essential to numerous biological functions. The exact mechanism of action for the lipid lowering action of ascorbic acid was still not revealed. With intent to propose the most probable mechanism of action of ascorbic acid the docking based computational analysis has been performed against the lipid lowering drug targets like ATP citrate lyase enzyme, lanosterol 14α-demethylase enzyme, squalene synthase enzyme, and Niemann Pick C1 like Protein. The docking analysis, chemical interactions, followed by the physicochemical based pharmacokinetic profiling has revealed that the ascorbic acid is executing its lipid lowering action via inhibiting the squalene synthase enzyme.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116369170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-27DOI: 10.36348/merjps.2022.v02i01.002
Shayara Bano, J. Malik
Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.
摘要:绿原酸(5- o -咖啡酰奎宁酸)是羟基肉桂酸家族的酚类化合物。这种多酚具有许多增强健康的特性，其中大多数与代谢综合征的治疗有关，包括抗氧化、抗炎、降脂、抗糖尿病和降压作用。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。食品中其它生物活性化合物的抗降解和益生元活性的保护特性。此外，绿原酸具有抗氧化特性，特别是抗脂质氧化。防止食物中其他生物活性化合物降解的保护特性和益生元活性。方法:采用AutoDock技术将COX2、NF-κB诱导激酶(NIK)和磷脂酶a2 (PLA2)与绿原酸进行分子对接。结果:分子对接结果显示绿原酸具有较高的对接评分。对接分数分别为-6.71、-6.31和-4.43 kcal mol-1。
{"title":"Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach","authors":"Shayara Bano, J. Malik","doi":"10.36348/merjps.2022.v02i01.002","DOIUrl":"https://doi.org/10.36348/merjps.2022.v02i01.002","url":null,"abstract":"Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125956023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-27DOI: 10.36348/merjps.2021.v01i01.003
U. B., M. C., Uba A, Muhammad A. A
Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.
{"title":"Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine","authors":"U. B., M. C., Uba A, Muhammad A. A","doi":"10.36348/merjps.2021.v01i01.003","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.003","url":null,"abstract":"Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124343605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-27DOI: 10.36348/merjps.2021.v01i01.002
Priyanka Ahirwar, J. Malik
Abstract: Diabetes mellitus is a chief cause involved in the morbidity and mortality among the global population (Steppan et al., 2001). The main event of this syndrome includes elevated blood glucose level (hyperglycemia) followed by polydipsia and polyuria. The secondary complications include retinal damage, loss of kidney function and damage to nerves. Further, the diabetes mellitus will also increase the cardiovascular disease progression. Pentacyclictriterpenes are as well one of the compounds occurring in plants. In this group Ursolic acid is a well-recognized compound that is accessible from various sources like seeds as well as fruits and possess many types of activities and is a bright contender for developing novel treatment approaches for treating diseases. Thus, in the current study, ursolic acid a triterpenoid was selected for evaluation of antidiabetic potential by molecular docking. A mechanistic insight for their antidiabetic potential is elucidating by interaction of ursolic acid with target proteins.
摘要:糖尿病是全球人群发病和死亡的主要原因之一(Steppan et al.， 2001)。该综合征的主要事件包括血糖水平升高(高血糖)，随后是多饮和多尿。继发性并发症包括视网膜损伤、肾功能丧失和神经损伤。此外，糖尿病还会增加心血管疾病的进展。五环三萜也是植物中存在的化合物之一。在这一组中，熊果酸是一种公认的化合物，可以从种子和水果等各种来源获得，具有多种类型的活性，是开发治疗疾病的新方法的有力竞争者。因此，在本研究中，我们选择熊果酸-三萜，通过分子对接来评价其抗糖尿病潜能。熊果酸与靶蛋白的相互作用阐明了其抗糖尿病潜能的机制。
{"title":"Mechanistic Insight Antidiabetic Potential of Ursolic Acid: In-Silico Molecular Docking","authors":"Priyanka Ahirwar, J. Malik","doi":"10.36348/merjps.2021.v01i01.002","DOIUrl":"https://doi.org/10.36348/merjps.2021.v01i01.002","url":null,"abstract":"Abstract: Diabetes mellitus is a chief cause involved in the morbidity and mortality among the global population (Steppan et al., 2001). The main event of this syndrome includes elevated blood glucose level (hyperglycemia) followed by polydipsia and polyuria. The secondary complications include retinal damage, loss of kidney function and damage to nerves. Further, the diabetes mellitus will also increase the cardiovascular disease progression. Pentacyclictriterpenes are as well one of the compounds occurring in plants. In this group Ursolic acid is a well-recognized compound that is accessible from various sources like seeds as well as fruits and possess many types of activities and is a bright contender for developing novel treatment approaches for treating diseases. Thus, in the current study, ursolic acid a triterpenoid was selected for evaluation of antidiabetic potential by molecular docking. A mechanistic insight for their antidiabetic potential is elucidating by interaction of ursolic acid with target proteins.","PeriodicalId":424241,"journal":{"name":"Middle East Research Journal of Pharmaceutical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124565838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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