Introduction: Warts are benign hyperkeratotic viral infections poorly responsive to most treatment modalities. Commonly used destructive methods can cause the scarring of the digits. Intralesional agents are preferred in digital warts. Individual efficacy has been assessed, but previously intralesional bleomycin and immunomodulator measles, mumps, and rubella (MMR) vaccine have not been compared. Objectives: To assess the effectiveness and safety of intralesional bleomycin versus intralesional MMR vaccine in the treatment of digital warts. Materials and Methods: All consenting adults with ≤5 digital warts were randomly divided into two groups by chit method: group A got intralesional MMR vaccine and group B got intralesional bleomycin monthly for 3 months with follow-up at the fourth month. Clearance and reduction in wart sizes and side effects were noted. Results: Totally 45 patients completed the study, and with single injection, clearance in group B was significantly higher than in group A (P = 0.001, Chi-square test). Necrosis, eschar formation, and residual pain were seen in group B. Overall, there was no significant difference in clearance rates at three injections (P = 0.198, chi-square test). Conclusion: Intralesional MMR vaccine and intralesional bleomycin are both effective in treating digital verrucae. Faster clearance is seen with intralesional bleomycin, with more side effects such as necrosis, eschar, and pain, controlled with oral analgesics.
{"title":"Intralesional MMR versus intralesional bleomycin in the treatment of digital warts: A randomized comparative study and review of the literature","authors":"Arunima Ray, I. Agrawal, B. Kar","doi":"10.4103/tjd.tjd_10_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_10_22","url":null,"abstract":"Introduction: Warts are benign hyperkeratotic viral infections poorly responsive to most treatment modalities. Commonly used destructive methods can cause the scarring of the digits. Intralesional agents are preferred in digital warts. Individual efficacy has been assessed, but previously intralesional bleomycin and immunomodulator measles, mumps, and rubella (MMR) vaccine have not been compared. Objectives: To assess the effectiveness and safety of intralesional bleomycin versus intralesional MMR vaccine in the treatment of digital warts. Materials and Methods: All consenting adults with ≤5 digital warts were randomly divided into two groups by chit method: group A got intralesional MMR vaccine and group B got intralesional bleomycin monthly for 3 months with follow-up at the fourth month. Clearance and reduction in wart sizes and side effects were noted. Results: Totally 45 patients completed the study, and with single injection, clearance in group B was significantly higher than in group A (P = 0.001, Chi-square test). Necrosis, eschar formation, and residual pain were seen in group B. Overall, there was no significant difference in clearance rates at three injections (P = 0.198, chi-square test). Conclusion: Intralesional MMR vaccine and intralesional bleomycin are both effective in treating digital verrucae. Faster clearance is seen with intralesional bleomycin, with more side effects such as necrosis, eschar, and pain, controlled with oral analgesics.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"37 1","pages":"73 - 79"},"PeriodicalIF":0.1,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90239872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Yanatma, G. Sarac, Hulya Cenk, Selami Arslan, İ. Durmaz, Gonca Ay
Objectives: Studies show that the symptoms are clustered in certain ways in Behçet’s disease (BD), which causes involvement of multiple organs. We aimed to investigate the association between clinical findings at onset and further organ involvements, which may occur during follow-up. Materials and Methods: A total of 363 patients diagnosed with BD in accordance with the International Criteria for BD (ICBD) between 2003 and 2019 at the Inonu University were included in the study, and all the first findings were compared with further organ involvements. Results: A statistical significance was detected between erythema nodosum like lesions and both pulmonary (P = 0.002) and vascular (P = 0.022) involvements. The frequency of neurological involvement was higher in patients with papulopustular/pseudo-follicular lesions (P = 0.043). Gastrointestinal involvement was detected in 33.3% of the patients with herpetiform aphthae. The frequency of ocular involvement was significantly higher in patients with a negative pathergy test result (P = 0.013). Conclusion: The clinical clusters in BD may provide a predictive value about the disease course for clinicians. Although it has been shown that there is an association between some clinical findings and involvements which are mentioned before, this is one of the most comprehensive studies according to us. The clinical clusters in BD may provide a predictive value about the disease course for clinicians. Although it has been shown that there is an association between some clinical findings and involvements in the literature, this is one of the most comprehensive studies as far as we know.
{"title":"Association between initial findings leading to Behçet’s disease diagnosis and further organ involvements","authors":"I. Yanatma, G. Sarac, Hulya Cenk, Selami Arslan, İ. Durmaz, Gonca Ay","doi":"10.4103/tjd.tjd_24_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_24_22","url":null,"abstract":"Objectives: Studies show that the symptoms are clustered in certain ways in Behçet’s disease (BD), which causes involvement of multiple organs. We aimed to investigate the association between clinical findings at onset and further organ involvements, which may occur during follow-up. Materials and Methods: A total of 363 patients diagnosed with BD in accordance with the International Criteria for BD (ICBD) between 2003 and 2019 at the Inonu University were included in the study, and all the first findings were compared with further organ involvements. Results: A statistical significance was detected between erythema nodosum like lesions and both pulmonary (P = 0.002) and vascular (P = 0.022) involvements. The frequency of neurological involvement was higher in patients with papulopustular/pseudo-follicular lesions (P = 0.043). Gastrointestinal involvement was detected in 33.3% of the patients with herpetiform aphthae. The frequency of ocular involvement was significantly higher in patients with a negative pathergy test result (P = 0.013). Conclusion: The clinical clusters in BD may provide a predictive value about the disease course for clinicians. Although it has been shown that there is an association between some clinical findings and involvements which are mentioned before, this is one of the most comprehensive studies according to us. The clinical clusters in BD may provide a predictive value about the disease course for clinicians. Although it has been shown that there is an association between some clinical findings and involvements in the literature, this is one of the most comprehensive studies as far as we know.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"66 3 1","pages":"92 - 97"},"PeriodicalIF":0.1,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87753625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kifayat Mammadli, A. Bilgic, H. İlhan, O. Dursun, M. Yılmaz, E. Alpsoy
Background: Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) are rare, acute, severe cutaneous hypersensitivity reactions usually triggered by medications. They are classified by the extent of the detached skin surface area. Objective: We aimed to retrospectively evaluate the sociodemographic, clinical, therapeutic, and prognostic characteristics of SJS/TEN cases diagnosed between January 2015 and December 2020 in our centre. Materials and Methods: All the data regarding patient characteristics were obtained retrospectively. The SCORe of Toxic Epidermal Necrolysis (SCORTEN) was used to predict disease severity and mortality rates. Results: Out of 20 patients (14 females, 6 males), eight (40%) were evaluated as TEN, three (15%) as SJS/ TEN overlap, and nine (45%) as SJS. The mean age was 39.2 ± 27.92 years. A higher frequency of systemic antibiotic use was found in cases of SJS/TEN overlap or TEN compared to SJS cases during patients’ follow-up after the diagnosis (P = 0.006). The most common responsible drug was allopurinol (25%). While the estimated mortality in patients with SCORTEN values of 4 and 5 was 58.3% and 90.0%, the mortality observed in our cohort was 50% and 100%, respectively. In terms of complications, ocular problems were the most common ones. Ophthalmic sequelae were observed in 15 patients during the follow-up period, the most common belonging to the cornea. Conclusion: In conclusion, early diagnosis, immediate discontinuation of suspected drugs, and good clinical care are among the most crucial treatment steps in the treatment of SJS/TEN. In addition, multidisciplinary management of the disease is vital in preventing the development of long-term sequelae in survivors.
{"title":"Retrospective analysis of cases with Stevens-Johnson syndrome/toxic epidermal necrolysis: A case series of 20 patients","authors":"Kifayat Mammadli, A. Bilgic, H. İlhan, O. Dursun, M. Yılmaz, E. Alpsoy","doi":"10.4103/tjd.tjd_13_22","DOIUrl":"https://doi.org/10.4103/tjd.tjd_13_22","url":null,"abstract":"Background: Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) are rare, acute, severe cutaneous hypersensitivity reactions usually triggered by medications. They are classified by the extent of the detached skin surface area. Objective: We aimed to retrospectively evaluate the sociodemographic, clinical, therapeutic, and prognostic characteristics of SJS/TEN cases diagnosed between January 2015 and December 2020 in our centre. Materials and Methods: All the data regarding patient characteristics were obtained retrospectively. The SCORe of Toxic Epidermal Necrolysis (SCORTEN) was used to predict disease severity and mortality rates. Results: Out of 20 patients (14 females, 6 males), eight (40%) were evaluated as TEN, three (15%) as SJS/ TEN overlap, and nine (45%) as SJS. The mean age was 39.2 ± 27.92 years. A higher frequency of systemic antibiotic use was found in cases of SJS/TEN overlap or TEN compared to SJS cases during patients’ follow-up after the diagnosis (P = 0.006). The most common responsible drug was allopurinol (25%). While the estimated mortality in patients with SCORTEN values of 4 and 5 was 58.3% and 90.0%, the mortality observed in our cohort was 50% and 100%, respectively. In terms of complications, ocular problems were the most common ones. Ophthalmic sequelae were observed in 15 patients during the follow-up period, the most common belonging to the cornea. Conclusion: In conclusion, early diagnosis, immediate discontinuation of suspected drugs, and good clinical care are among the most crucial treatment steps in the treatment of SJS/TEN. In addition, multidisciplinary management of the disease is vital in preventing the development of long-term sequelae in survivors.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"35 1","pages":"80 - 86"},"PeriodicalIF":0.1,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77280648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.
{"title":"The comparative study to determine the efficacy of 0.05% tazarotene gel versus 0.1% adapalene gel in patients of facial acne vulgaris","authors":"A. Deshmukh, Sanmitra Aiholli, B. Naik","doi":"10.4103/tjd.tjd_128_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_128_21","url":null,"abstract":"Introduction: Acne vulgaris is one of the most common skin disorders that present to Dermatology clinics. The majority of the patients suffer from mild-to-moderate acne, for which topical retinoids form the mainstay of treatment. Aims and Objectives: The aim of this article is to study and determine the efficacy and tolerability of 0.05% tazarotene gel against 0.1% adapalene gel in facial acne vulgaris. Materials and Methods: Eighty-two facial acne vulgaris patients were randomly divided into two groups. Group A was given 0.05% tazarotene gel, and group B received 0.1% adapalene gel to be applied overnight for a period of 8 weeks. Lesion counting and photographs were recorded every 15 days. Results: The mean difference on first follow-up from baseline for tazarotene and adapalene was 6.80 ± 6.42 and 1.48 ± 10.44, and the P-value was 0.013. The final follow-up visit values were 34.77 ± 23.73 and 25.48 ± 13.04, with a P-value of 0.051. The mean percentage change from baseline to last follow-up for tazarotene and adapalene was 60% and 51%, respectively, which were statistically significant for both groups (P < 0.05). More patients in the tazarotene group developed cutaneous side effects such as erythema and burning sensation than those in the adapalene group (P < 0.05). conclusion: About 0.05% tazarotene gel has better efficacy than 0.1% adapalene, though associated with more side effects. It can be used as a topical adjunct or as monotherapy in mild-to-moderate facial acne vulgaris.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"31 1","pages":"87 - 91"},"PeriodicalIF":0.1,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76739498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: In various studies, it is shown that cutaneous metastases of solid organ cancers are associated with advanced stage disease, lower disease-specific survival rate, and poor prognosis. Metastatic cutaneous disease may be observed in different morphologies. Histopathologically epidermal/dermal/epidermodermal infiltration, solid/nodular structures, interstitial pattern, and perineural invasion may be evident as accompanying features. In the present study, we aim to analyze demographical, histopathological, and clinical characteristics of cutaneous metastases from solid organ cancers in 37 patients. Materials And Methods: Thirty-seven patients diagnosed with biopsy-proven cutaneous metastases of solid organ cancers between January 2006 and January 2019 were retrospectively evaluated in the study. Results: Breast cancer was the primary cancer in 22 patients, whereas 13 patients were diagnosed with other solid organ cancers. The most common solid cancer which presented with skin metastases was breast cancer (22, 59.5%) followed by lung cancer (3, 8.1%), whereas colorectal cancer and lung cancer were the two most common cancers which metastasized to the skin in male patients. Two patients had cancer of primary unknown. The mean age at the diagnosis of first cutaneous metastasis was 58.1 ± 12.4 years. Twenty-six (70.3%) patients had primary cancer diagnosed first, whereas 11 (29.7%) patients had cutaneous metastasis diagnosed first. Breast cancer is shown to metastasize to the trunk at a significantly higher rate compared with other types of solid cancers (P = 0.02). Nodule (37.8%, 14) was the most frequently observed primary lesion of the cutaneous metastases morphologically, followed by plaque (18.9%, n = 7), tumor (13.5%, n = 5), and papule (8.1%, n = 3). Seven (18.9%) patients presented with more than one morphology. Histopathologically, micronodular structure was the most commonly observed structure. The mean time between the diagnosis of primary cancer and death was 60.62 ± 53.93 months (range: 6–156). The mean duration between the appearance of cutaneous metastasis and death was 10.5 ± 6.4 months (range: 1–24). There was not any statistically significant difference between the primary cancer type and the eluded time between death and primary cancer diagnosis. In addition, we were not able to find any statistically significant relationship between living-to-dead ratio and primary cancer type, presence of other organ metastases, and treatment status at the time of the emergence of cutaneous metastases. Conclusion: All in all, we would like to highlight the importance of diagnostic skin biopsy, especially in elderly patients presenting with cutaneous nodules of unknown origin. The possibility of cutaneous metastasis should always be kept in mind in patients with a history of malignancy even after long periods of recovery.
{"title":"Clinical and histopathological characteristics of cutaneous metastases from solid organ cancers: Experience of dermatology in a tertiary referral hospital","authors":"Ecem Bostan, N. Akdoğan, O. Gokoz","doi":"10.4103/tjd.tjd_123_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_123_21","url":null,"abstract":"Background/Aim: In various studies, it is shown that cutaneous metastases of solid organ cancers are associated with advanced stage disease, lower disease-specific survival rate, and poor prognosis. Metastatic cutaneous disease may be observed in different morphologies. Histopathologically epidermal/dermal/epidermodermal infiltration, solid/nodular structures, interstitial pattern, and perineural invasion may be evident as accompanying features. In the present study, we aim to analyze demographical, histopathological, and clinical characteristics of cutaneous metastases from solid organ cancers in 37 patients. Materials And Methods: Thirty-seven patients diagnosed with biopsy-proven cutaneous metastases of solid organ cancers between January 2006 and January 2019 were retrospectively evaluated in the study. Results: Breast cancer was the primary cancer in 22 patients, whereas 13 patients were diagnosed with other solid organ cancers. The most common solid cancer which presented with skin metastases was breast cancer (22, 59.5%) followed by lung cancer (3, 8.1%), whereas colorectal cancer and lung cancer were the two most common cancers which metastasized to the skin in male patients. Two patients had cancer of primary unknown. The mean age at the diagnosis of first cutaneous metastasis was 58.1 ± 12.4 years. Twenty-six (70.3%) patients had primary cancer diagnosed first, whereas 11 (29.7%) patients had cutaneous metastasis diagnosed first. Breast cancer is shown to metastasize to the trunk at a significantly higher rate compared with other types of solid cancers (P = 0.02). Nodule (37.8%, 14) was the most frequently observed primary lesion of the cutaneous metastases morphologically, followed by plaque (18.9%, n = 7), tumor (13.5%, n = 5), and papule (8.1%, n = 3). Seven (18.9%) patients presented with more than one morphology. Histopathologically, micronodular structure was the most commonly observed structure. The mean time between the diagnosis of primary cancer and death was 60.62 ± 53.93 months (range: 6–156). The mean duration between the appearance of cutaneous metastasis and death was 10.5 ± 6.4 months (range: 1–24). There was not any statistically significant difference between the primary cancer type and the eluded time between death and primary cancer diagnosis. In addition, we were not able to find any statistically significant relationship between living-to-dead ratio and primary cancer type, presence of other organ metastases, and treatment status at the time of the emergence of cutaneous metastases. Conclusion: All in all, we would like to highlight the importance of diagnostic skin biopsy, especially in elderly patients presenting with cutaneous nodules of unknown origin. The possibility of cutaneous metastasis should always be kept in mind in patients with a history of malignancy even after long periods of recovery.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"26 1","pages":"44 - 51"},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72525171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There are few studies investigating the association between psoriasis and depression, anxiety, sexual dysfunction in the literature. Aims: We aimed to investigate depression, anxiety, and sexual dysfunction in patients with psoriasis and the association between the psychiatric comorbidity and the severity and involvement sites of psoriasis. Materials and Methods: A total of 200 participants, including 100 psoriasis patients and 100 healthy volunteers as a control group, were included in the study. All participants were questioned about sociodemographic characteristics, smoking, alcohol use, and comorbidities. All participants completed the Dermatology Life Quality Index, Beck Depression Scale, Beck Anxiety Scale, Arizona Sexual Experiences Scale, Female Sexual Function Scale/International Erectile Function Index. Results: In the psoriasis group, an increased risk for depression and anxiety was observed, regardless of the clinical features and severity of psoriasis, and a positive correlation was detected between the severity of the disease and impaired quality of life. An increased risk for sexual dysfunction regardless of clinical features and severity in male patients with psoriasis was detected compared with the control group. It was found that the risk for erectile dysfunction in patients with psoriasis increased regardless of the risk factors such as smoking, alcohol, diabetes, hypertension, and cardiovascular disease. Conclusion: Our study shows that psoriasis increases the risk for impaired quality of life, depression, anxiety, and sexual dysfunction in individuals. This increase is not always associated with the clinical characteristics of psoriasis such as severity, duration, and sites of involvement. Therefore, dermatologists should consider not only the skin findings of psoriasis but also the psychosocial status of the patient and refer the patient to psychiatry if necessary.
{"title":"Anxiety, depression, and sexual dysfunction in patients with psoriasis","authors":"Y. Doğan, F. Kılıç, S. Özçelik","doi":"10.4103/tjd.tjd_146_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_146_21","url":null,"abstract":"Background: There are few studies investigating the association between psoriasis and depression, anxiety, sexual dysfunction in the literature. Aims: We aimed to investigate depression, anxiety, and sexual dysfunction in patients with psoriasis and the association between the psychiatric comorbidity and the severity and involvement sites of psoriasis. Materials and Methods: A total of 200 participants, including 100 psoriasis patients and 100 healthy volunteers as a control group, were included in the study. All participants were questioned about sociodemographic characteristics, smoking, alcohol use, and comorbidities. All participants completed the Dermatology Life Quality Index, Beck Depression Scale, Beck Anxiety Scale, Arizona Sexual Experiences Scale, Female Sexual Function Scale/International Erectile Function Index. Results: In the psoriasis group, an increased risk for depression and anxiety was observed, regardless of the clinical features and severity of psoriasis, and a positive correlation was detected between the severity of the disease and impaired quality of life. An increased risk for sexual dysfunction regardless of clinical features and severity in male patients with psoriasis was detected compared with the control group. It was found that the risk for erectile dysfunction in patients with psoriasis increased regardless of the risk factors such as smoking, alcohol, diabetes, hypertension, and cardiovascular disease. Conclusion: Our study shows that psoriasis increases the risk for impaired quality of life, depression, anxiety, and sexual dysfunction in individuals. This increase is not always associated with the clinical characteristics of psoriasis such as severity, duration, and sites of involvement. Therefore, dermatologists should consider not only the skin findings of psoriasis but also the psychosocial status of the patient and refer the patient to psychiatry if necessary.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"47 1","pages":"62 - 69"},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85205242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Gunes, P. Uysal, B. Yalçın, Ç. Yücel, Ömer Kutlu
Objectives: T cells, keratinocytes, dendritic cells, inflammatory cytokines including tumor necrosis factor α are involved in the pathogenesis of psoriasis. The anti-inflammatory effect of progranulin (PGRN) is known by inhibiting the effects of Tumor Necrosis Factor (TNF- α). We aimed to evaluate the PGRN levels and the factors affecting PGRN levels in patients with psoriasis. Materials and Methods: The study enrolled 44 patients with psoriasis and 44 age- and sex- matched healthy controls. Serum PGRN levels were measured in all participants and compared between the two groups. PGRN levels were also evaluated in terms of demographic data, duration of disease, age of onset, previous treatments, smoking and drinking habits, PASI scores, and presence of nail and joint involvement in the psoriasis group. Results: Mean serum PGRN levels were significantly higher (10.70 ± 2.56ng/ml) in the psoriasis group than in the control group (3.16 ± 1.02ng/ml) (P < 0.001). There was no significant relationship between serum PGRN levels and clinical characteristics of psoriasis including the presence of joint and nail involvement, PASI scores, duration of disease, age of onset. Conclusions: In conclusion, psoriasis patients have elevated serum levels of PGRN irrespective of patient and clinical characteristics. To increase knowledge on the effect of PGRN in the pathogenesis of psoriasis can lead to new therapeutic options for the disease.
{"title":"Evaluation of serum progranulin levels in patients with psoriasis: A case-control study","authors":"R. Gunes, P. Uysal, B. Yalçın, Ç. Yücel, Ömer Kutlu","doi":"10.4103/tjd.tjd_67_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_67_21","url":null,"abstract":"Objectives: T cells, keratinocytes, dendritic cells, inflammatory cytokines including tumor necrosis factor α are involved in the pathogenesis of psoriasis. The anti-inflammatory effect of progranulin (PGRN) is known by inhibiting the effects of Tumor Necrosis Factor (TNF- α). We aimed to evaluate the PGRN levels and the factors affecting PGRN levels in patients with psoriasis. Materials and Methods: The study enrolled 44 patients with psoriasis and 44 age- and sex- matched healthy controls. Serum PGRN levels were measured in all participants and compared between the two groups. PGRN levels were also evaluated in terms of demographic data, duration of disease, age of onset, previous treatments, smoking and drinking habits, PASI scores, and presence of nail and joint involvement in the psoriasis group. Results: Mean serum PGRN levels were significantly higher (10.70 ± 2.56ng/ml) in the psoriasis group than in the control group (3.16 ± 1.02ng/ml) (P < 0.001). There was no significant relationship between serum PGRN levels and clinical characteristics of psoriasis including the presence of joint and nail involvement, PASI scores, duration of disease, age of onset. Conclusions: In conclusion, psoriasis patients have elevated serum levels of PGRN irrespective of patient and clinical characteristics. To increase knowledge on the effect of PGRN in the pathogenesis of psoriasis can lead to new therapeutic options for the disease.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"43 1","pages":"52 - 56"},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78535165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Lichen planus (LP) is a chronic inflammatory and immune-mediated disease characterized by multiple clinical presentations. There are very few studies analyzing histopathological features of LP worldwide. Objectives: The aim of this work was to study different histopathological patterns in skin biopsies of LP and to correlate the clinical and histopathological features. Materials and Methods: Records of 184 biopsies diagnosed as LP were included in the study. Clinical data from the records reviewed. Hematoxylin and eosin-stained sections were retrieved, re-examined, and histopathological parameters were noted. Results: Among the 184 biopsies of LP patients, pigment incontinence (93.5%) was the most common followed by hypergranulosis (88%) and interface dermatitis (82.6%). In epidermal changes, saw-toothed acanthosis (90, 48.9%) was the most common followed by the flattened epidermis (47, 25.5%), irregular moderate acanthosis with appendageal involvement (31, 16.9%), and pseudocarcinomatous hyperplasia (16, 8.7%). In tissue reaction patterns, the lichenoid pattern was the most common (131, 71.2%) followed by mild superficial perivascular dermatitis (MSPVD) in 20 (10.9%) followed by various combination patterns. The types of hypergranulosis seen were wedge-shaped (86, 53.1%) followed by infundibular (32, 19.8%), regular (30, 18.5%), and acrosyringeal (14, 8.6%). Changes of venous stasis were observed in 41% of lower limb biopsies. Conclusion: On histopathology, pigment incontinence and hypergranulosis were the most consistent features in all types of LP. Awareness about the less frequent patterns may improve the diagnostic accuracy of clinicopathologic correlation.
{"title":"A retrospective study of skin biopsies of 184 cutaneous lichen planus patients","authors":"H. Pathave, V. Nikam, A. Dongre, U. Khopkar","doi":"10.4103/tjd.tjd_116_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_116_21","url":null,"abstract":"Background: Lichen planus (LP) is a chronic inflammatory and immune-mediated disease characterized by multiple clinical presentations. There are very few studies analyzing histopathological features of LP worldwide. Objectives: The aim of this work was to study different histopathological patterns in skin biopsies of LP and to correlate the clinical and histopathological features. Materials and Methods: Records of 184 biopsies diagnosed as LP were included in the study. Clinical data from the records reviewed. Hematoxylin and eosin-stained sections were retrieved, re-examined, and histopathological parameters were noted. Results: Among the 184 biopsies of LP patients, pigment incontinence (93.5%) was the most common followed by hypergranulosis (88%) and interface dermatitis (82.6%). In epidermal changes, saw-toothed acanthosis (90, 48.9%) was the most common followed by the flattened epidermis (47, 25.5%), irregular moderate acanthosis with appendageal involvement (31, 16.9%), and pseudocarcinomatous hyperplasia (16, 8.7%). In tissue reaction patterns, the lichenoid pattern was the most common (131, 71.2%) followed by mild superficial perivascular dermatitis (MSPVD) in 20 (10.9%) followed by various combination patterns. The types of hypergranulosis seen were wedge-shaped (86, 53.1%) followed by infundibular (32, 19.8%), regular (30, 18.5%), and acrosyringeal (14, 8.6%). Changes of venous stasis were observed in 41% of lower limb biopsies. Conclusion: On histopathology, pigment incontinence and hypergranulosis were the most consistent features in all types of LP. Awareness about the less frequent patterns may improve the diagnostic accuracy of clinicopathologic correlation.","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"58 1","pages":"38 - 43"},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87646142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Segmental leiomyoma: A report of two cases","authors":"M. Al-Mendalawi","doi":"10.4103/tjd.tjd_133_21","DOIUrl":"https://doi.org/10.4103/tjd.tjd_133_21","url":null,"abstract":"","PeriodicalId":42454,"journal":{"name":"Turk Dermatoloji Dergisi-Turkish Journal of Dermatology","volume":"5 1","pages":"70 - 70"},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73937110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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