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Fatigue is Related to Insulin Use by Acting Via Depressive Mood in Patients with Diabetes Mellitus 糖尿病患者抑郁情绪作用下的疲劳与胰岛素使用有关
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71576
Özlem Haliloğlu, Mesude Tütüncü, S. Şahin, Ozge Polat Korkmaz, Melis Dila Özer, Z. Siva
Objective: Fatigue is a common symptom in diabetes mellitus. The aim of this study was to determine the factors leading to fatigue and to investigate the effect of insulin use on fatigue among the diabetic population. Material and Methods: Onehundred diabetic patients attending the diabetes clinic of Cerrahpasa Medical Faculty between October 2017-January 2018 and 42 healthy controls were evaluated in this cross-sectional study. Questionnaires including demographic and disease characteristics, Fatigue Impact Scale (FIS), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), quality of life scale (SF-36), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) were used. Results: Ages (47.6±14.8 and 45.7±14.1 years; p=0.47) and body mass indices (26.6±4.1 and 25.3±3.5 kg/m2; p=0.08) of 100 patients with diabetes (Type 1 Diabetes/Type 2 Diabetes= 29/71) and 42 healthy volunteers were similar. The diabetic group had worse FIS total (p=0.05), FIS psychological (p=0.04) scores and SF–36 scores compared to the healthy controls. When the patients with diabetes were divided into two groups according to insulin use and compared with healthy controls, the ESS and PSQI were similar but all FIS parameters (total p=0.005, cognitive p=0.007, physical p=0.01, psychological p=0.009) and BDI (p=0.05) were significantly worse in patients with insulin use than non-insulin and control groups. The relationship between fatigue and insulin use was independent of glycemic control and duration of diabetes but was affected by the BDI (p=0.001). Conclusion: Insulin use leads to fatigue in patients with diabetes, regardless of diabetes type, and this effect is influenced by depressive mood. Psychotherapeutic approaches prior to insulin treatment might yield fruitful
目的:疲劳是糖尿病的常见症状。本研究的目的是确定导致疲劳的因素,并调查胰岛素使用对糖尿病人群疲劳的影响。材料与方法:本横断面研究评估了2017年10月至2018年1月期间在Cerrahpasa医学院糖尿病诊所就诊的100名糖尿病患者和42名健康对照者。采用人口统计学和疾病特征问卷、疲劳影响量表(FIS)、疲劳严重程度量表(FSS)、贝克抑郁量表(BDI)、生活质量量表(SF-36)、Epworth嗜睡量表(ESS)和匹兹堡睡眠质量指数(PSQI)。结果:年龄分别为47.6±14.8岁和45.7±14.1岁;P =0.47),体重指数分别为26.6±4.1和25.3±3.5 kg/m2;p=0.08), 100例糖尿病患者(1型糖尿病/ 2型糖尿病= 29/71)与42名健康志愿者相似。糖尿病组FIS总分(p=0.05)、FIS心理评分(p=0.04)、SF-36评分均低于健康对照组。将糖尿病患者按胰岛素使用情况分为两组,与健康对照组比较,胰岛素使用组的ESS和PSQI基本相同,但FIS参数(总p=0.005,认知p=0.007,生理p=0.01,心理p=0.009)和BDI (p=0.05)均显著低于非胰岛素组和对照组。疲劳和胰岛素使用之间的关系与血糖控制和糖尿病病程无关,但受BDI的影响(p=0.001)。结论:胰岛素使用可导致糖尿病患者的疲劳,且这种作用受抑郁情绪的影响。在胰岛素治疗之前的心理治疗方法可能会产生丰硕的成果
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引用次数: 0
The Case of a Multi-Locular Bronchogenic Cyst Found in Periadrenal Fatty Tissue 肾上腺周围脂肪组织中发现多房支气管源性囊肿一例
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71985
Y. Günay, S. Kisioglu, E. Çakir, Selçuk Akkaya, H. Coskun
Introduction Bronchogenic cysts (BC) are rare congenital cystic lesions formed during the migration of embryonic primitive foregut buds during early embryogenesis (1). They are usually found in the posterior mediastinum, but they may rarely be found in adrenal glands (2). Morphologically, they have the same characteristics as the tracheobronchial system. Most BC are asymptomatic in the early stages, but they can become symptomatic because of pressure caused by the cyst in the surrounding area. Additionally, BC can cause bleeding, rupture or infections (3). Malignant transformation is very rare, with only 0.7% risk (4). A case study, in which a bronchogenic cyst was located in the adrenal area, was presented to us. Bronchogenic cysts are rare congenital cystic lesion formed during the migration of embryonic primitive foregut buds during early embryogenesis. Although they are most commonly located in the mediastinum, in some rare cases, they are found localized in the periadrenal area. In our male patient in 22 year old who had no symptomps, a multiloculated bronchogenic cyst was detected incidentally in the periadrenal area. The lesion was located in the left adrenal area as observed using imaging techniques. The large mass was extracted by laparoscopy to confirm the diagnosis. Histopathological examination described the cyst as multilocular and bronchogenic. The case was presented to us because of the rare occurrence of bronchogenic cysts in the periadrenal area, and an accompanying ectopic kidney condition.
支气管原性囊肿(Bronchogenic cysts, BC)是一种罕见的先天性囊性病变,是胚胎发生早期胚胎原始前肠芽迁移过程中形成的(1)。通常见于后纵隔,但很少见于肾上腺(2)。在形态学上,与气管支气管系统具有相同的特征。大多数BC在早期阶段是无症状的,但由于周围区域的囊肿造成的压力,它们可能会出现症状。此外,BC可引起出血、破裂或感染(3)。恶性转化非常罕见,风险仅为0.7%(4)。我们报告了一例位于肾上腺区支气管源性囊肿的病例研究。支气管囊肿是一种罕见的先天性囊性病变,是在胚胎发生早期胚胎原始前肠芽迁移过程中形成的。虽然它们最常位于纵隔,但在一些罕见的病例中,它们也被发现局限于肾上腺周围区域。我们的22岁男性患者没有任何症状,在肾上腺周围偶然发现了一个多室支气管源性囊肿。病变位于左肾上腺区,通过成像技术观察。腹腔镜下取出大肿块以确认诊断。组织病理学检查显示该囊肿为多房性支气管源性。我们之所以提出这个病例,是因为在肾上腺周围区域有罕见的支气管囊肿,并伴有异位肾脏。
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引用次数: 0
Relationship Between Leptin to Adiponectin Ratio and Metabolic Syndrome Indices in Apparently Healthy Adults 表面健康成人瘦素/脂联素比值与代谢综合征指标的关系
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-70761
A. T. Esfanjani, Sevda Saleh Ghadimi, Mehrangiz Ebrahimi Mameghani, M. Jafarabadi, M. Ehteshami, Jalal Moloudi, Vahid Maleki, H. Omidi, Hamed Jafari Vayghan
122 Objective: Leptin/adiponectin (L/A) ratio is considered a predicting factor of metabolic syndrome (MetS) and its related morbidities. In the present study, we determined the association of serum L/A ratio with MetS parameters in apparently healthy Iranian adults. Material and Methods: This cross-sectional study was conducted on 150 apparently healthy adults aged 25 to 50 years, who were selected by random sampling from different medical centers of Tabriz city, Iran. Our criteria for being a healthy individual were based on self-report of the participants. Anthropometric measures, fasting blood sugar (FBS) and lipid profile, systolic and diastolic blood pressure (SBP and DBP), and fasting serum L/A levels were measured. Results: There were significant differences (p<0.05) in weight, height, waist circumference (WC), SBP, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), serum leptin concentration, and L/A ratio between males and females. Univariate linear regression model revealed a significant positive association of serum leptin concentration with WC (p=0.024) and FBS (p=0.046). A similar result was obtained using the multiple regression model after adjusting for confounding factors (p<0.001 and p=0.045). A significant positive correlation was found between the L/A ratio and WC (p=0.010) in the adjusted model. However, no significant association was observed between adiponectin and MetS indices. Conclusion: Our findings indicated a significant positive association of serum leptin concentration with WC and FBS and between L/A ratio and WC in apparently healthy adults. Therefore, compared to adiponectin, leptin, and L/A ratio could be useful predictors of MetS.
目的:瘦素/脂联素(L/A)比值被认为是代谢综合征(MetS)及其相关发病率的预测因素。在本研究中,我们确定了表面健康的伊朗成年人血清L/A比值与MetS参数的关系。材料与方法:本横断面研究采用随机抽样方法,从伊朗大不里士市不同医疗中心抽取150名表面健康的25 ~ 50岁成年人。我们对健康个体的标准是基于参与者的自我报告。测量人体测量、空腹血糖(FBS)和血脂、收缩压和舒张压(SBP和DBP)以及空腹血清L/A水平。结果:男性与女性在体重、身高、腰围、收缩压、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、血清瘦素浓度、L/A比值等指标上差异均有统计学意义(p<0.05)。单变量线性回归模型显示血清瘦素浓度与WC (p=0.024)和FBS (p=0.046)呈正相关。在调整混杂因素后,使用多元回归模型获得了类似的结果(p<0.001和p=0.045)。在调整后的模型中,L/A比率与WC呈显著正相关(p=0.010)。然而,脂联素和MetS指数之间没有明显的关联。结论:我们的研究结果表明,在表面健康的成年人中,血清瘦素浓度与WC和FBS以及L/ a比和WC之间存在显著正相关。因此,脂联素、瘦素和L/A比值可以作为代谢当量的有效预测因子。
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引用次数: 0
T Helper 1 Cytokines and Their Relationship with Beta Cell Function in Type 1 Diabetes T辅助1细胞因子及其与1型糖尿病β细胞功能的关系
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71070
G. Tamer, B. Basok, Burcu Doğan, O. Caklili, O. Kostek
İstanbul Medeniyet University Göztepe Training and Research Hospital, Division of Endocrinology and Metabolism, İstanbul, TURKEY *University of Health Sciences, İzmir Tepecik Training and Research Hospital, Department of Biochemistry, İzmir, TURKEY **İstanbul Medeniyet University Göztepe Training and Research Hospital, Department of Family Medicine, İstanbul, TURKEY ***İstanbul University Faculty of Medicine, Department of Endocrinology and Metabolism, İstanbul, TURKEY ****Trakya University Faculty of Medicine, Department of Oncology, Edirne, TURKEY Original Article Turk J Endocrinol Metab. 2020;24:177-183
İstanbul Medeniyet Goztepe培训和研究大学医院的内分泌和新陈代谢,İstanbul,土耳其*健康科学大学İ世界Tepecik培训和研究医院,生物化学,İ世界土耳其* *İstanbul Medeniyet Goztepe培训和研究大学医院,家庭医学学系İstanbul,土耳其* * *İstanbul大学医学院内分泌和新陈代谢,İstanbul,土耳其****土耳其特拉基亚大学医学院,肿瘤学系,埃迪尔内,土耳其[J] .内分泌杂志,2020;24:177-183
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引用次数: 0
A Rare Combination: Multiple Endocrine Neoplasia Type 1 and Follicular Thyroid Carcinoma 罕见的合并:多发性内分泌肿瘤1型和滤泡性甲状腺癌
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-70603
A. Gorgel, S. N. Gorgel, M. Demirpençe, M. Bahçeci
Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary syndrome associated with pituitary, parathyroid, and enteropancreatic endocrine tumors. Its estimated prevalence ranges from 1 in 10,000 to 100,000 (1). The syndrome arises from mutations of a putative tumor suppressor gene at chromosome 11q13 which encodes a 610amino acid protein, menin. Although the cellular and biochemical functions of menin are not well-known, loss of heterozygosity of the MEN1 locus appears in MEN1-related tumors (2). Patients with MEN-1 inherit an inactivated copy of MEN-1 in all cells; a second inactivation occurs postnatally in certain cells and neoplasia results from clonal expansion of the cells with dual inactivation (3). Abstract Multiple endocrine neoplasia Type 1 (MEN-1) is an inherited syndrome characterized by the development of endocrine tumors of the pancreas, parathyroid, and pituitary glands. Mesenchymal tumors and adrenal neoplasms might also accompany this syndrome. However, the syndrome is rarely associated with thyroid tumors in contrary to the multiple endocrine neoplasia Type 2 that includes medullary thyroid carcinoma. This case study presents a 44-year-old woman who was diagnosed with MEN-1 on the basis of her clinical characteristics, laboratory data, and the presence of endocrine tumors. Follicular thyroid carcinoma was detected in the patient when she was being operated for nodular goiter, 12 years ago. We report this rare case which is likely the third case in the available scientific literature.
1型多发性内分泌瘤(MEN1)是一种常染色体显性遗传综合征,与垂体、甲状旁腺和肠胰腺内分泌肿瘤相关。据估计,其发病率在1万分之一到10万分之一之间。该综合征是由染色体11q13上一个推定的肿瘤抑制基因突变引起的,该基因编码610个氨基酸的蛋白质,menin。尽管menin的细胞和生化功能尚不清楚,但MEN1位点的杂合性缺失出现在与MEN1相关的肿瘤中(2)。MEN1患者在所有细胞中都遗传了MEN1的失活拷贝;某些细胞在出生后发生第二次失活,双失活细胞的克隆扩增导致肿瘤形成(3)。1型多发性内分泌瘤(men1)是一种以胰腺、甲状旁腺和垂体内分泌肿瘤为特征的遗传综合征。间充质肿瘤和肾上腺肿瘤也可能伴随这种综合征。然而,与包括甲状腺髓样癌在内的多发性内分泌肿瘤2型相反,该综合征很少与甲状腺肿瘤相关。本病例研究报告了一名44岁的女性,根据她的临床特征、实验室数据和内分泌肿瘤的存在被诊断为man -1。12年前,当患者因结节性甲状腺肿接受手术时,发现了滤泡性甲状腺癌。我们报告这个罕见的病例,这可能是现有科学文献中的第三个病例。
{"title":"A Rare Combination: Multiple Endocrine Neoplasia Type 1 and Follicular Thyroid Carcinoma","authors":"A. Gorgel, S. N. Gorgel, M. Demirpençe, M. Bahçeci","doi":"10.25179/tjem.2019-70603","DOIUrl":"https://doi.org/10.25179/tjem.2019-70603","url":null,"abstract":"Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary syndrome associated with pituitary, parathyroid, and enteropancreatic endocrine tumors. Its estimated prevalence ranges from 1 in 10,000 to 100,000 (1). The syndrome arises from mutations of a putative tumor suppressor gene at chromosome 11q13 which encodes a 610amino acid protein, menin. Although the cellular and biochemical functions of menin are not well-known, loss of heterozygosity of the MEN1 locus appears in MEN1-related tumors (2). Patients with MEN-1 inherit an inactivated copy of MEN-1 in all cells; a second inactivation occurs postnatally in certain cells and neoplasia results from clonal expansion of the cells with dual inactivation (3). Abstract Multiple endocrine neoplasia Type 1 (MEN-1) is an inherited syndrome characterized by the development of endocrine tumors of the pancreas, parathyroid, and pituitary glands. Mesenchymal tumors and adrenal neoplasms might also accompany this syndrome. However, the syndrome is rarely associated with thyroid tumors in contrary to the multiple endocrine neoplasia Type 2 that includes medullary thyroid carcinoma. This case study presents a 44-year-old woman who was diagnosed with MEN-1 on the basis of her clinical characteristics, laboratory data, and the presence of endocrine tumors. Follicular thyroid carcinoma was detected in the patient when she was being operated for nodular goiter, 12 years ago. We report this rare case which is likely the third case in the available scientific literature.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"123 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74566164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Falsely Highlighted Intestinal Intraluminal Areas and the Fat in Paraspinal Muscles on Abdominal Adipose Tissue Measurements Using Computed Tomography 错误显示肠道腔内区域和棘旁肌肉脂肪对计算机断层扫描腹部脂肪组织测量的影响
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74562
M. Baris, A. Peker, A. Yener, N. Gezer, M. Seçil
Objective: The measurement of abdominal fat using computed tomography (CT) is a reliable method for evaluating metabolic disorders. However, some limitations exist with the current CT measurement methods. One of them is falsely highlighted intestinal intraluminal areas and the other one is fat in paraspinal muscles. We aimed to investigate the effects of highlighted intestinal intraluminal areas and fat in paraspinal muscles on the measured values of abdominal fat. Material and Methods: Measurements were performed on 246 abdominal CT scans of 129 patients using dedicated quantitative CT software. Visceral and subcutaneous fats were measured at the level of L1-L2 disc space using two different methods. Method 1 included the highlighted intestinal intraluminal areas and fat in paraspinal muscles for measurements, whereas method 2 excluded them. The values measured using two methods were compared for a statistically significant difference. In addition, the correlation between anthropometric data and subcutaneous adipose tissue measurement methods was analyzed. Results: The mean age of patients was 53 years, and the mean body mass index was 29.73 kg/m2. The waist circumference data were available of 91 patients, and the mean waist circumference was 94 cm. The Wilcoxon signed-rank sum test showed a statistically significant difference between methods 1 and 2 (p<0.0001). Although the measurements performed using methods 1 and 2 were strongly correlated (r>0.9), the Passing-Bablok regression analysis indicated a systematic and proportional error between measurements. Conclusion: Falsely highlighted intestinal intraluminal areas should be excluded for accurate visceral adipose tissue measurements, and the fat in paraspinal muscles affects subcutaneous fat measurement results.
目的:利用计算机断层扫描(CT)测量腹部脂肪是一种评估代谢紊乱的可靠方法。然而,目前的CT测量方法存在一些局限性。其中一个是错误地突出肠腔内区域,另一个是棘旁肌肉的脂肪。我们的目的是研究突出的肠腔内区域和棘旁肌肉脂肪对腹部脂肪测量值的影响。材料与方法:使用专用的定量CT软件对129例患者的246张腹部CT扫描进行测量。采用两种不同的方法在L1-L2椎间盘间隙水平测量内脏和皮下脂肪。方法1将突出的肠腔内区域和棘旁肌脂肪进行测量,方法2将其排除。比较两种方法的测量值是否有统计学上的显著差异。此外,还分析了人体测量数据与皮下脂肪组织测量方法之间的相关性。结果:患者平均年龄53岁,平均体重指数29.73 kg/m2。91例患者的腰围资料,平均腰围为94 cm。Wilcoxon符号秩和检验显示方法1和方法2的差异有统计学意义(p0.9), Passing-Bablok回归分析显示测量结果之间存在系统和比例误差。结论:为了准确测量内脏脂肪组织,应排除错误突出的肠道腔内区域,棘旁肌肉的脂肪影响皮下脂肪测量结果。
{"title":"The Effect of Falsely Highlighted Intestinal Intraluminal Areas and the Fat in Paraspinal Muscles on Abdominal Adipose Tissue Measurements Using Computed Tomography","authors":"M. Baris, A. Peker, A. Yener, N. Gezer, M. Seçil","doi":"10.25179/tjem.2020-74562","DOIUrl":"https://doi.org/10.25179/tjem.2020-74562","url":null,"abstract":"Objective: The measurement of abdominal fat using computed tomography (CT) is a reliable method for evaluating metabolic disorders. However, some limitations exist with the current CT measurement methods. One of them is falsely highlighted intestinal intraluminal areas and the other one is fat in paraspinal muscles. We aimed to investigate the effects of highlighted intestinal intraluminal areas and fat in paraspinal muscles on the measured values of abdominal fat. Material and Methods: Measurements were performed on 246 abdominal CT scans of 129 patients using dedicated quantitative CT software. Visceral and subcutaneous fats were measured at the level of L1-L2 disc space using two different methods. Method 1 included the highlighted intestinal intraluminal areas and fat in paraspinal muscles for measurements, whereas method 2 excluded them. The values measured using two methods were compared for a statistically significant difference. In addition, the correlation between anthropometric data and subcutaneous adipose tissue measurement methods was analyzed. Results: The mean age of patients was 53 years, and the mean body mass index was 29.73 kg/m2. The waist circumference data were available of 91 patients, and the mean waist circumference was 94 cm. The Wilcoxon signed-rank sum test showed a statistically significant difference between methods 1 and 2 (p<0.0001). Although the measurements performed using methods 1 and 2 were strongly correlated (r>0.9), the Passing-Bablok regression analysis indicated a systematic and proportional error between measurements. Conclusion: Falsely highlighted intestinal intraluminal areas should be excluded for accurate visceral adipose tissue measurements, and the fat in paraspinal muscles affects subcutaneous fat measurement results.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"24 1","pages":"214-220"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82561294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity is Associated with Increased Thyroid Volume and Heterogeneity in Ultrasonography 肥胖与甲状腺体积增加和超声检查的异质性有关
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71171
Abbas Ali Tam, D. Ozdemir, Berna Evranos Öğmen, F. Dellal, A. Alkan, O. Topaloğlu, R. Ersoy, B. Çakır
Objective: The aim of the present study was to investigate the possible association between obesity and thyroid functions and thyroid morphology. Material and Methods: A total of 674 subjects-121 obese and 553 nonobese-were included in the study. Body mass index, serum thyrotrophic, free triiodothyronine (fT3), free thyroxine (fT4), antithyroid peroxidase antibody, and antithyroglobulin antibody (antiTg) were evaluated in each subject. The subjects with thyroid nodules in ultrasonography (USG) were excluded. The thyroid volume of each subject was calculated and analyzed. Results: Obesity was significantly associated with increased age and low fT4 in univariate analysis (p<0.05). With multivariate analysis, the odds of obesity was found to increase by 21.8% (95% CI: 12.4-31.9%) for each 5-year increase in age anddecrease by 53.1% (95% CI: 0.4-77.9%) for each 1 ng/dL increase in fT4. The odds of obesity in patients with positive antiTg was 1.603 (95% 1.047-2.454) times higher than the odds of obesity in patients with negative antiTg. The median total thyroid volume was significantly higher in obese as compared to nonobese subjects (12.11 mL vs. 10.77 mL, p<0.001). Heterogeneous gland with negative thyroid antibodies was observed in 17 (14%) obese and 40 (7.2%) nonobese subjects (p=0.024). Conclusion: Obesity was positively associated with antiTg and age, whereas negatively associated with fT4. Approximately, in every seven obese subjects, one showed heterogeneity in US despite negative thyroid autoantibodies. This suggests that the value of US in the diagnosis of autoimmune thyroiditis might decrease in obese patients.
目的:本研究的目的是探讨肥胖与甲状腺功能和甲状腺形态之间可能的联系。材料与方法:本研究共纳入674名受试者,其中肥胖121人,非肥胖553人。测定体重指数、血清甲状腺功能、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体(antiTg)。排除超声检查有甲状腺结节的受试者。计算并分析每个受试者的甲状腺体积。结果:单因素分析显示,肥胖与年龄增加、fT4低显著相关(p<0.05)。通过多变量分析,发现年龄每增加5年,肥胖的几率增加21.8% (95% CI: 12.4-31.9%), fT4每增加1 ng/dL,肥胖的几率减少53.1% (95% CI: 0.4-77.9%)。抗tg阳性患者发生肥胖的几率是抗tg阴性患者的1.603倍(95% 1.047 ~ 2.454)。肥胖患者甲状腺总容积中位数明显高于非肥胖患者(12.11 mL vs. 10.77 mL, p<0.001)。肥胖患者17例(14%)甲状腺抗体阴性,非肥胖患者40例(7.2%)甲状腺抗体阴性(p=0.024)。结论:肥胖与抗tg和年龄呈正相关,与fT4呈负相关。大约每7名肥胖受试者中,就有1人在美国表现出异质性,尽管甲状腺自身抗体呈阴性。这表明在肥胖患者中,US在自身免疫性甲状腺炎诊断中的价值可能会降低。
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引用次数: 1
Factors Affecting Survival in Adrenocortical Cancers: Single-Center Experience 影响肾上腺皮质癌患者生存的因素:单中心经验
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74861
M. Güven, Mehmet Şimşek, A. Tuzcu
Objective: Adrenocortical cancer (ACC) is one of the rare endocrine system cancers that are aggressive. Despite surgical treatment, the mortality rate is quite high. This study aimed to examine prognostic factors affecting survival in patients with ACC, the role of dehydroepiandrosterone sulfate (DHEA-S), and the maximum standard uptake (SUVmax) values on predicting mortality through the single-center data. Material and Methods: A total of 21 patients who were diagnosed with adrenal cancer and followed from a single center were included in the study. Patients who survived follow-ups were included in the survived group (n=6), and those who died were included in the dead group (n=15). The demographic, anatomical, pathological, and clinical characteristics of the patients were analyzed. Positron emission tomography-computerized tomography imaging and SUVmax values of adrenal masses were compared. The effect of all these data on survival was examined. Results: The mortality rate among patients with ACC was 71%. According to the Kaplan-Meier survival analysis, the average life expectancy was 23.66±2.79 (95% CI=18.18-29.13) months. The mass size of the survived and dead groups was 9.2±3.82 cm and 10.84±4.74 cm, respectively. The production rate of adrenal hormone was higher in the dead group (p<0.01; 80%). Moreover, the DHEA-S level and SUVmax values were statistically significantly higher in the dead group (p<0.001; p<0.05, respectively). Although no metastases were observed in the survived group during follow-ups after the operation, distant metastases were observed in 8 people from the dead group (53%; p<0.05). Conclusion: The mortality rate was very high in ACC despite surgical and medical treatments. The higher DHEA-S and SUVmax values may indicate that the overall survival duration was low.
目的:肾上腺皮质癌是一种罕见的侵袭性内分泌系统肿瘤。尽管进行了手术治疗,但死亡率仍然很高。本研究旨在通过单中心数据研究影响ACC患者生存的预后因素、硫酸脱氢表雄酮(DHEA-S)的作用以及最大标准摄取(SUVmax)值对预测死亡率的作用。材料和方法:本研究共纳入了21例诊断为肾上腺癌并来自单一中心的患者。随访存活患者为存活组(n=6),死亡患者为死亡组(n=15)。分析患者的人口学、解剖学、病理学和临床特征。比较肾上腺肿块的正电子发射层析成像和SUVmax值。研究了所有这些数据对生存的影响。结果:ACC患者死亡率为71%。根据Kaplan-Meier生存分析,平均预期寿命为23.66±2.79 (95% CI=18.18-29.13)个月。存活组和死亡组的体重分别为9.2±3.82 cm和10.84±4.74 cm。死亡组肾上腺素生成率较高(p<0.01);80%)。死亡组DHEA-S水平和SUVmax值均显著高于死亡组(p<0.001;分别为p < 0.05)。术后随访中存活组未见转移,但死亡组有8例(53%;p < 0.05)。结论:尽管手术和药物治疗,ACC的死亡率仍然很高。较高的DHEA-S和SUVmax值可能表明总体生存时间较低。
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引用次数: 0
Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus 1型糖尿病孕妇持续皮下胰岛素输注治疗的急性并发症和妊娠结局
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-74444
I. Sari, A. Altinova, C. Ozkan, M. Akturk, Ceyla Konca Değertekin, E. T. Cerit, M. Yalçın, F. Törüner, A. Karakoc, I. Yetkin, G. Ayvaz, N. Çakır
Turkish and English summaries of the manuscript should take place in a manner that it will not exceed 250 words. The keywords should be written at the end of the summary. The references should not be cited in the summary section. As far as possible, use of abbreviations is to be avoided. If any abbreviations are used, they must be taken into consideration independently of the abbreviations used in the text. The summary should be written with four running titles. Purpose: The goal of the study should be clearly stated. Material and Method: The study should be defined, the standard criteria; it should be also indicated whether the study is randomized or not, whether it is retrospective or prospective, the statistical method, if any, should be indicated. Results (Findings): The detailed result of the study should be given and the statistical significance level should be indicated. OF TURKEY JOURNAL OF THE SOCIETY OF END ABOLISM OCRINOLOGY AND MET
文稿的土耳其语和英语摘要应以不超过250字的方式进行。关键词应该写在摘要的最后。参考文献不应该在摘要部分被引用。尽量避免使用缩略语。如果使用任何缩写,它们必须独立于文本中使用的缩写来考虑。摘要应该用四个连续的标题来写。目的:研究的目的应明确说明。材料和方法:研究应明确,标准标准;还应指出研究是否是随机的,是回顾性的还是前瞻性的,如果有统计方法,应指出。结果(发现):应给出详细的研究结果,并指出统计显著性水平。土耳其废奴主义与人类学学会会刊
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引用次数: 1
Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis 桥本甲状腺炎患者血清8-OHdG水平
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2020-77613
F. Esfahanian, Seyedeh Mahdieh Fotouk Kiaie, Roghayeh Ghelich, Z. Jadali
Introduction Hashimoto’s thyroiditis (HT) is characterized by diffuse lymphocytic infiltration of the thyroid gland and elevated level of antithyroidspecific autoantibodies. It is more prevalent among women, and its incidence has increased significantly in recent years (1). Although autoimmunity plays a pivotal role in Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among different markers of oxidative damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure the level of 8-OHdG in the sera of patients with HT and healthy control (HC) participants. Material and Methods: In this study, patients were diagnosed with clinical (n=23) and subclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measured using enzyme-linked immunosorbent assay in patients and HC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patients and HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of 8-OHdG is a biomarker of oxidative stress in patients with HT. However, more detailed studies are needed to reveal the exact role of 8-OHdG in this autoimmune disease of the thyroid gland.
桥本甲状腺炎的特点是甲状腺弥漫性淋巴细胞浸润和抗甲状腺特异性自身抗体水平升高。它在女性中更为普遍,近年来发病率显著增加(1)。尽管自身免疫在其中起着关键作用目的:越来越多的证据表明氧化应激与自身免疫性疾病(如桥本甲状腺炎(HT))之间存在密切关系。在不同的氧化损伤标志物中,8-羟基脱氧鸟苷(8-OHdG)是一种普遍存在的标志物,被广泛应用于研究。因此,本研究旨在测量HT患者和健康对照(HC)参与者血清中8-OHdG的水平。材料与方法:在本研究中,患者被诊断为临床(n=23)和亚临床(n=25)甲状腺功能减退症,并与35名健康参与者进行比较。采用酶联免疫吸附法测定患者和HC参与者的8-OHdG。结果:患者和HC参与者的平均血清8-OHdG水平无显著差异。结论:本初步研究结果不支持血清8-OHdG水平是HT患者氧化应激的生物标志物。然而,需要更详细的研究来揭示8-OHdG在这种甲状腺自身免疫性疾病中的确切作用。
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Turkish Journal of Endocrinology and Metabolism
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