Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-71576
Özlem Haliloğlu, Mesude Tütüncü, S. Şahin, Ozge Polat Korkmaz, Melis Dila Özer, Z. Siva
Objective: Fatigue is a common symptom in diabetes mellitus. The aim of this study was to determine the factors leading to fatigue and to investigate the effect of insulin use on fatigue among the diabetic population. Material and Methods: Onehundred diabetic patients attending the diabetes clinic of Cerrahpasa Medical Faculty between October 2017-January 2018 and 42 healthy controls were evaluated in this cross-sectional study. Questionnaires including demographic and disease characteristics, Fatigue Impact Scale (FIS), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), quality of life scale (SF-36), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) were used. Results: Ages (47.6±14.8 and 45.7±14.1 years; p=0.47) and body mass indices (26.6±4.1 and 25.3±3.5 kg/m2; p=0.08) of 100 patients with diabetes (Type 1 Diabetes/Type 2 Diabetes= 29/71) and 42 healthy volunteers were similar. The diabetic group had worse FIS total (p=0.05), FIS psychological (p=0.04) scores and SF–36 scores compared to the healthy controls. When the patients with diabetes were divided into two groups according to insulin use and compared with healthy controls, the ESS and PSQI were similar but all FIS parameters (total p=0.005, cognitive p=0.007, physical p=0.01, psychological p=0.009) and BDI (p=0.05) were significantly worse in patients with insulin use than non-insulin and control groups. The relationship between fatigue and insulin use was independent of glycemic control and duration of diabetes but was affected by the BDI (p=0.001). Conclusion: Insulin use leads to fatigue in patients with diabetes, regardless of diabetes type, and this effect is influenced by depressive mood. Psychotherapeutic approaches prior to insulin treatment might yield fruitful
{"title":"Fatigue is Related to Insulin Use by Acting Via Depressive Mood in Patients with Diabetes Mellitus","authors":"Özlem Haliloğlu, Mesude Tütüncü, S. Şahin, Ozge Polat Korkmaz, Melis Dila Özer, Z. Siva","doi":"10.25179/tjem.2019-71576","DOIUrl":"https://doi.org/10.25179/tjem.2019-71576","url":null,"abstract":"Objective: Fatigue is a common symptom in diabetes mellitus. The aim of this study was to determine the factors leading to fatigue and to investigate the effect of insulin use on fatigue among the diabetic population. Material and Methods: Onehundred diabetic patients attending the diabetes clinic of Cerrahpasa Medical Faculty between October 2017-January 2018 and 42 healthy controls were evaluated in this cross-sectional study. Questionnaires including demographic and disease characteristics, Fatigue Impact Scale (FIS), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), quality of life scale (SF-36), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) were used. Results: Ages (47.6±14.8 and 45.7±14.1 years; p=0.47) and body mass indices (26.6±4.1 and 25.3±3.5 kg/m2; p=0.08) of 100 patients with diabetes (Type 1 Diabetes/Type 2 Diabetes= 29/71) and 42 healthy volunteers were similar. The diabetic group had worse FIS total (p=0.05), FIS psychological (p=0.04) scores and SF–36 scores compared to the healthy controls. When the patients with diabetes were divided into two groups according to insulin use and compared with healthy controls, the ESS and PSQI were similar but all FIS parameters (total p=0.005, cognitive p=0.007, physical p=0.01, psychological p=0.009) and BDI (p=0.05) were significantly worse in patients with insulin use than non-insulin and control groups. The relationship between fatigue and insulin use was independent of glycemic control and duration of diabetes but was affected by the BDI (p=0.001). Conclusion: Insulin use leads to fatigue in patients with diabetes, regardless of diabetes type, and this effect is influenced by depressive mood. Psychotherapeutic approaches prior to insulin treatment might yield fruitful","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":"29-37"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86674603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-71985
Y. Günay, S. Kisioglu, E. Çakir, Selçuk Akkaya, H. Coskun
Introduction Bronchogenic cysts (BC) are rare congenital cystic lesions formed during the migration of embryonic primitive foregut buds during early embryogenesis (1). They are usually found in the posterior mediastinum, but they may rarely be found in adrenal glands (2). Morphologically, they have the same characteristics as the tracheobronchial system. Most BC are asymptomatic in the early stages, but they can become symptomatic because of pressure caused by the cyst in the surrounding area. Additionally, BC can cause bleeding, rupture or infections (3). Malignant transformation is very rare, with only 0.7% risk (4). A case study, in which a bronchogenic cyst was located in the adrenal area, was presented to us. Bronchogenic cysts are rare congenital cystic lesion formed during the migration of embryonic primitive foregut buds during early embryogenesis. Although they are most commonly located in the mediastinum, in some rare cases, they are found localized in the periadrenal area. In our male patient in 22 year old who had no symptomps, a multiloculated bronchogenic cyst was detected incidentally in the periadrenal area. The lesion was located in the left adrenal area as observed using imaging techniques. The large mass was extracted by laparoscopy to confirm the diagnosis. Histopathological examination described the cyst as multilocular and bronchogenic. The case was presented to us because of the rare occurrence of bronchogenic cysts in the periadrenal area, and an accompanying ectopic kidney condition.
{"title":"The Case of a Multi-Locular Bronchogenic Cyst Found in Periadrenal Fatty Tissue","authors":"Y. Günay, S. Kisioglu, E. Çakir, Selçuk Akkaya, H. Coskun","doi":"10.25179/tjem.2019-71985","DOIUrl":"https://doi.org/10.25179/tjem.2019-71985","url":null,"abstract":"Introduction Bronchogenic cysts (BC) are rare congenital cystic lesions formed during the migration of embryonic primitive foregut buds during early embryogenesis (1). They are usually found in the posterior mediastinum, but they may rarely be found in adrenal glands (2). Morphologically, they have the same characteristics as the tracheobronchial system. Most BC are asymptomatic in the early stages, but they can become symptomatic because of pressure caused by the cyst in the surrounding area. Additionally, BC can cause bleeding, rupture or infections (3). Malignant transformation is very rare, with only 0.7% risk (4). A case study, in which a bronchogenic cyst was located in the adrenal area, was presented to us. Bronchogenic cysts are rare congenital cystic lesion formed during the migration of embryonic primitive foregut buds during early embryogenesis. Although they are most commonly located in the mediastinum, in some rare cases, they are found localized in the periadrenal area. In our male patient in 22 year old who had no symptomps, a multiloculated bronchogenic cyst was detected incidentally in the periadrenal area. The lesion was located in the left adrenal area as observed using imaging techniques. The large mass was extracted by laparoscopy to confirm the diagnosis. Histopathological examination described the cyst as multilocular and bronchogenic. The case was presented to us because of the rare occurrence of bronchogenic cysts in the periadrenal area, and an accompanying ectopic kidney condition.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"13 1","pages":"163-167"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86787669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-70761
A. T. Esfanjani, Sevda Saleh Ghadimi, Mehrangiz Ebrahimi Mameghani, M. Jafarabadi, M. Ehteshami, Jalal Moloudi, Vahid Maleki, H. Omidi, Hamed Jafari Vayghan
122 Objective: Leptin/adiponectin (L/A) ratio is considered a predicting factor of metabolic syndrome (MetS) and its related morbidities. In the present study, we determined the association of serum L/A ratio with MetS parameters in apparently healthy Iranian adults. Material and Methods: This cross-sectional study was conducted on 150 apparently healthy adults aged 25 to 50 years, who were selected by random sampling from different medical centers of Tabriz city, Iran. Our criteria for being a healthy individual were based on self-report of the participants. Anthropometric measures, fasting blood sugar (FBS) and lipid profile, systolic and diastolic blood pressure (SBP and DBP), and fasting serum L/A levels were measured. Results: There were significant differences (p<0.05) in weight, height, waist circumference (WC), SBP, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), serum leptin concentration, and L/A ratio between males and females. Univariate linear regression model revealed a significant positive association of serum leptin concentration with WC (p=0.024) and FBS (p=0.046). A similar result was obtained using the multiple regression model after adjusting for confounding factors (p<0.001 and p=0.045). A significant positive correlation was found between the L/A ratio and WC (p=0.010) in the adjusted model. However, no significant association was observed between adiponectin and MetS indices. Conclusion: Our findings indicated a significant positive association of serum leptin concentration with WC and FBS and between L/A ratio and WC in apparently healthy adults. Therefore, compared to adiponectin, leptin, and L/A ratio could be useful predictors of MetS.
{"title":"Relationship Between Leptin to Adiponectin Ratio and Metabolic Syndrome Indices in Apparently Healthy Adults","authors":"A. T. Esfanjani, Sevda Saleh Ghadimi, Mehrangiz Ebrahimi Mameghani, M. Jafarabadi, M. Ehteshami, Jalal Moloudi, Vahid Maleki, H. Omidi, Hamed Jafari Vayghan","doi":"10.25179/tjem.2019-70761","DOIUrl":"https://doi.org/10.25179/tjem.2019-70761","url":null,"abstract":"122 Objective: Leptin/adiponectin (L/A) ratio is considered a predicting factor of metabolic syndrome (MetS) and its related morbidities. In the present study, we determined the association of serum L/A ratio with MetS parameters in apparently healthy Iranian adults. Material and Methods: This cross-sectional study was conducted on 150 apparently healthy adults aged 25 to 50 years, who were selected by random sampling from different medical centers of Tabriz city, Iran. Our criteria for being a healthy individual were based on self-report of the participants. Anthropometric measures, fasting blood sugar (FBS) and lipid profile, systolic and diastolic blood pressure (SBP and DBP), and fasting serum L/A levels were measured. Results: There were significant differences (p<0.05) in weight, height, waist circumference (WC), SBP, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), serum leptin concentration, and L/A ratio between males and females. Univariate linear regression model revealed a significant positive association of serum leptin concentration with WC (p=0.024) and FBS (p=0.046). A similar result was obtained using the multiple regression model after adjusting for confounding factors (p<0.001 and p=0.045). A significant positive correlation was found between the L/A ratio and WC (p=0.010) in the adjusted model. However, no significant association was observed between adiponectin and MetS indices. Conclusion: Our findings indicated a significant positive association of serum leptin concentration with WC and FBS and between L/A ratio and WC in apparently healthy adults. Therefore, compared to adiponectin, leptin, and L/A ratio could be useful predictors of MetS.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"43 1","pages":"122-131"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75666025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-71070
G. Tamer, B. Basok, Burcu Doğan, O. Caklili, O. Kostek
İstanbul Medeniyet University Göztepe Training and Research Hospital, Division of Endocrinology and Metabolism, İstanbul, TURKEY *University of Health Sciences, İzmir Tepecik Training and Research Hospital, Department of Biochemistry, İzmir, TURKEY **İstanbul Medeniyet University Göztepe Training and Research Hospital, Department of Family Medicine, İstanbul, TURKEY ***İstanbul University Faculty of Medicine, Department of Endocrinology and Metabolism, İstanbul, TURKEY ****Trakya University Faculty of Medicine, Department of Oncology, Edirne, TURKEY Original Article Turk J Endocrinol Metab. 2020;24:177-183
İstanbul Medeniyet Goztepe培训和研究大学医院的内分泌和新陈代谢,İstanbul,土耳其*健康科学大学İ世界Tepecik培训和研究医院,生物化学,İ世界土耳其* *İstanbul Medeniyet Goztepe培训和研究大学医院,家庭医学学系İstanbul,土耳其* * *İstanbul大学医学院内分泌和新陈代谢,İstanbul,土耳其****土耳其特拉基亚大学医学院，肿瘤学系，埃迪尔内，土耳其[J] .内分泌杂志，2020;24:177-183
{"title":"T Helper 1 Cytokines and Their Relationship with Beta Cell Function in Type 1 Diabetes","authors":"G. Tamer, B. Basok, Burcu Doğan, O. Caklili, O. Kostek","doi":"10.25179/tjem.2019-71070","DOIUrl":"https://doi.org/10.25179/tjem.2019-71070","url":null,"abstract":"İstanbul Medeniyet University Göztepe Training and Research Hospital, Division of Endocrinology and Metabolism, İstanbul, TURKEY *University of Health Sciences, İzmir Tepecik Training and Research Hospital, Department of Biochemistry, İzmir, TURKEY **İstanbul Medeniyet University Göztepe Training and Research Hospital, Department of Family Medicine, İstanbul, TURKEY ***İstanbul University Faculty of Medicine, Department of Endocrinology and Metabolism, İstanbul, TURKEY ****Trakya University Faculty of Medicine, Department of Oncology, Edirne, TURKEY Original Article Turk J Endocrinol Metab. 2020;24:177-183","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"16 1","pages":"177-183"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82680792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-70603
A. Gorgel, S. N. Gorgel, M. Demirpençe, M. Bahçeci
Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary syndrome associated with pituitary, parathyroid, and enteropancreatic endocrine tumors. Its estimated prevalence ranges from 1 in 10,000 to 100,000 (1). The syndrome arises from mutations of a putative tumor suppressor gene at chromosome 11q13 which encodes a 610amino acid protein, menin. Although the cellular and biochemical functions of menin are not well-known, loss of heterozygosity of the MEN1 locus appears in MEN1-related tumors (2). Patients with MEN-1 inherit an inactivated copy of MEN-1 in all cells; a second inactivation occurs postnatally in certain cells and neoplasia results from clonal expansion of the cells with dual inactivation (3). Abstract Multiple endocrine neoplasia Type 1 (MEN-1) is an inherited syndrome characterized by the development of endocrine tumors of the pancreas, parathyroid, and pituitary glands. Mesenchymal tumors and adrenal neoplasms might also accompany this syndrome. However, the syndrome is rarely associated with thyroid tumors in contrary to the multiple endocrine neoplasia Type 2 that includes medullary thyroid carcinoma. This case study presents a 44-year-old woman who was diagnosed with MEN-1 on the basis of her clinical characteristics, laboratory data, and the presence of endocrine tumors. Follicular thyroid carcinoma was detected in the patient when she was being operated for nodular goiter, 12 years ago. We report this rare case which is likely the third case in the available scientific literature.
{"title":"A Rare Combination: Multiple Endocrine Neoplasia Type 1 and Follicular Thyroid Carcinoma","authors":"A. Gorgel, S. N. Gorgel, M. Demirpençe, M. Bahçeci","doi":"10.25179/tjem.2019-70603","DOIUrl":"https://doi.org/10.25179/tjem.2019-70603","url":null,"abstract":"Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary syndrome associated with pituitary, parathyroid, and enteropancreatic endocrine tumors. Its estimated prevalence ranges from 1 in 10,000 to 100,000 (1). The syndrome arises from mutations of a putative tumor suppressor gene at chromosome 11q13 which encodes a 610amino acid protein, menin. Although the cellular and biochemical functions of menin are not well-known, loss of heterozygosity of the MEN1 locus appears in MEN1-related tumors (2). Patients with MEN-1 inherit an inactivated copy of MEN-1 in all cells; a second inactivation occurs postnatally in certain cells and neoplasia results from clonal expansion of the cells with dual inactivation (3). Abstract Multiple endocrine neoplasia Type 1 (MEN-1) is an inherited syndrome characterized by the development of endocrine tumors of the pancreas, parathyroid, and pituitary glands. Mesenchymal tumors and adrenal neoplasms might also accompany this syndrome. However, the syndrome is rarely associated with thyroid tumors in contrary to the multiple endocrine neoplasia Type 2 that includes medullary thyroid carcinoma. This case study presents a 44-year-old woman who was diagnosed with MEN-1 on the basis of her clinical characteristics, laboratory data, and the presence of endocrine tumors. Follicular thyroid carcinoma was detected in the patient when she was being operated for nodular goiter, 12 years ago. We report this rare case which is likely the third case in the available scientific literature.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"123 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74566164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74562
M. Baris, A. Peker, A. Yener, N. Gezer, M. Seçil
Objective: The measurement of abdominal fat using computed tomography (CT) is a reliable method for evaluating metabolic disorders. However, some limitations exist with the current CT measurement methods. One of them is falsely highlighted intestinal intraluminal areas and the other one is fat in paraspinal muscles. We aimed to investigate the effects of highlighted intestinal intraluminal areas and fat in paraspinal muscles on the measured values of abdominal fat. Material and Methods: Measurements were performed on 246 abdominal CT scans of 129 patients using dedicated quantitative CT software. Visceral and subcutaneous fats were measured at the level of L1-L2 disc space using two different methods. Method 1 included the highlighted intestinal intraluminal areas and fat in paraspinal muscles for measurements, whereas method 2 excluded them. The values measured using two methods were compared for a statistically significant difference. In addition, the correlation between anthropometric data and subcutaneous adipose tissue measurement methods was analyzed. Results: The mean age of patients was 53 years, and the mean body mass index was 29.73 kg/m2. The waist circumference data were available of 91 patients, and the mean waist circumference was 94 cm. The Wilcoxon signed-rank sum test showed a statistically significant difference between methods 1 and 2 (p<0.0001). Although the measurements performed using methods 1 and 2 were strongly correlated (r>0.9), the Passing-Bablok regression analysis indicated a systematic and proportional error between measurements. Conclusion: Falsely highlighted intestinal intraluminal areas should be excluded for accurate visceral adipose tissue measurements, and the fat in paraspinal muscles affects subcutaneous fat measurement results.
{"title":"The Effect of Falsely Highlighted Intestinal Intraluminal Areas and the Fat in Paraspinal Muscles on Abdominal Adipose Tissue Measurements Using Computed Tomography","authors":"M. Baris, A. Peker, A. Yener, N. Gezer, M. Seçil","doi":"10.25179/tjem.2020-74562","DOIUrl":"https://doi.org/10.25179/tjem.2020-74562","url":null,"abstract":"Objective: The measurement of abdominal fat using computed tomography (CT) is a reliable method for evaluating metabolic disorders. However, some limitations exist with the current CT measurement methods. One of them is falsely highlighted intestinal intraluminal areas and the other one is fat in paraspinal muscles. We aimed to investigate the effects of highlighted intestinal intraluminal areas and fat in paraspinal muscles on the measured values of abdominal fat. Material and Methods: Measurements were performed on 246 abdominal CT scans of 129 patients using dedicated quantitative CT software. Visceral and subcutaneous fats were measured at the level of L1-L2 disc space using two different methods. Method 1 included the highlighted intestinal intraluminal areas and fat in paraspinal muscles for measurements, whereas method 2 excluded them. The values measured using two methods were compared for a statistically significant difference. In addition, the correlation between anthropometric data and subcutaneous adipose tissue measurement methods was analyzed. Results: The mean age of patients was 53 years, and the mean body mass index was 29.73 kg/m2. The waist circumference data were available of 91 patients, and the mean waist circumference was 94 cm. The Wilcoxon signed-rank sum test showed a statistically significant difference between methods 1 and 2 (p<0.0001). Although the measurements performed using methods 1 and 2 were strongly correlated (r>0.9), the Passing-Bablok regression analysis indicated a systematic and proportional error between measurements. Conclusion: Falsely highlighted intestinal intraluminal areas should be excluded for accurate visceral adipose tissue measurements, and the fat in paraspinal muscles affects subcutaneous fat measurement results.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"24 1","pages":"214-220"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82561294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2019-71171
Abbas Ali Tam, D. Ozdemir, Berna Evranos Öğmen, F. Dellal, A. Alkan, O. Topaloğlu, R. Ersoy, B. Çakır
Objective: The aim of the present study was to investigate the possible association between obesity and thyroid functions and thyroid morphology. Material and Methods: A total of 674 subjects-121 obese and 553 nonobese-were included in the study. Body mass index, serum thyrotrophic, free triiodothyronine (fT3), free thyroxine (fT4), antithyroid peroxidase antibody, and antithyroglobulin antibody (antiTg) were evaluated in each subject. The subjects with thyroid nodules in ultrasonography (USG) were excluded. The thyroid volume of each subject was calculated and analyzed. Results: Obesity was significantly associated with increased age and low fT4 in univariate analysis (p<0.05). With multivariate analysis, the odds of obesity was found to increase by 21.8% (95% CI: 12.4-31.9%) for each 5-year increase in age anddecrease by 53.1% (95% CI: 0.4-77.9%) for each 1 ng/dL increase in fT4. The odds of obesity in patients with positive antiTg was 1.603 (95% 1.047-2.454) times higher than the odds of obesity in patients with negative antiTg. The median total thyroid volume was significantly higher in obese as compared to nonobese subjects (12.11 mL vs. 10.77 mL, p<0.001). Heterogeneous gland with negative thyroid antibodies was observed in 17 (14%) obese and 40 (7.2%) nonobese subjects (p=0.024). Conclusion: Obesity was positively associated with antiTg and age, whereas negatively associated with fT4. Approximately, in every seven obese subjects, one showed heterogeneity in US despite negative thyroid autoantibodies. This suggests that the value of US in the diagnosis of autoimmune thyroiditis might decrease in obese patients.
目的:本研究的目的是探讨肥胖与甲状腺功能和甲状腺形态之间可能的联系。材料与方法:本研究共纳入674名受试者，其中肥胖121人，非肥胖553人。测定体重指数、血清甲状腺功能、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体(antiTg)。排除超声检查有甲状腺结节的受试者。计算并分析每个受试者的甲状腺体积。结果:单因素分析显示，肥胖与年龄增加、fT4低显著相关(p<0.05)。通过多变量分析，发现年龄每增加5年，肥胖的几率增加21.8% (95% CI: 12.4-31.9%)， fT4每增加1 ng/dL，肥胖的几率减少53.1% (95% CI: 0.4-77.9%)。抗tg阳性患者发生肥胖的几率是抗tg阴性患者的1.603倍(95% 1.047 ~ 2.454)。肥胖患者甲状腺总容积中位数明显高于非肥胖患者(12.11 mL vs. 10.77 mL, p<0.001)。肥胖患者17例(14%)甲状腺抗体阴性，非肥胖患者40例(7.2%)甲状腺抗体阴性(p=0.024)。结论:肥胖与抗tg和年龄呈正相关，与fT4呈负相关。大约每7名肥胖受试者中，就有1人在美国表现出异质性，尽管甲状腺自身抗体呈阴性。这表明在肥胖患者中，US在自身免疫性甲状腺炎诊断中的价值可能会降低。
{"title":"Obesity is Associated with Increased Thyroid Volume and Heterogeneity in Ultrasonography","authors":"Abbas Ali Tam, D. Ozdemir, Berna Evranos Öğmen, F. Dellal, A. Alkan, O. Topaloğlu, R. Ersoy, B. Çakır","doi":"10.25179/tjem.2019-71171","DOIUrl":"https://doi.org/10.25179/tjem.2019-71171","url":null,"abstract":"Objective: The aim of the present study was to investigate the possible association between obesity and thyroid functions and thyroid morphology. Material and Methods: A total of 674 subjects-121 obese and 553 nonobese-were included in the study. Body mass index, serum thyrotrophic, free triiodothyronine (fT3), free thyroxine (fT4), antithyroid peroxidase antibody, and antithyroglobulin antibody (antiTg) were evaluated in each subject. The subjects with thyroid nodules in ultrasonography (USG) were excluded. The thyroid volume of each subject was calculated and analyzed. Results: Obesity was significantly associated with increased age and low fT4 in univariate analysis (p<0.05). With multivariate analysis, the odds of obesity was found to increase by 21.8% (95% CI: 12.4-31.9%) for each 5-year increase in age anddecrease by 53.1% (95% CI: 0.4-77.9%) for each 1 ng/dL increase in fT4. The odds of obesity in patients with positive antiTg was 1.603 (95% 1.047-2.454) times higher than the odds of obesity in patients with negative antiTg. The median total thyroid volume was significantly higher in obese as compared to nonobese subjects (12.11 mL vs. 10.77 mL, p<0.001). Heterogeneous gland with negative thyroid antibodies was observed in 17 (14%) obese and 40 (7.2%) nonobese subjects (p=0.024). Conclusion: Obesity was positively associated with antiTg and age, whereas negatively associated with fT4. Approximately, in every seven obese subjects, one showed heterogeneity in US despite negative thyroid autoantibodies. This suggests that the value of US in the diagnosis of autoimmune thyroiditis might decrease in obese patients.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"51 1","pages":"9-15"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79800309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74861
M. Güven, Mehmet Şimşek, A. Tuzcu
Objective: Adrenocortical cancer (ACC) is one of the rare endocrine system cancers that are aggressive. Despite surgical treatment, the mortality rate is quite high. This study aimed to examine prognostic factors affecting survival in patients with ACC, the role of dehydroepiandrosterone sulfate (DHEA-S), and the maximum standard uptake (SUVmax) values on predicting mortality through the single-center data. Material and Methods: A total of 21 patients who were diagnosed with adrenal cancer and followed from a single center were included in the study. Patients who survived follow-ups were included in the survived group (n=6), and those who died were included in the dead group (n=15). The demographic, anatomical, pathological, and clinical characteristics of the patients were analyzed. Positron emission tomography-computerized tomography imaging and SUVmax values of adrenal masses were compared. The effect of all these data on survival was examined. Results: The mortality rate among patients with ACC was 71%. According to the Kaplan-Meier survival analysis, the average life expectancy was 23.66±2.79 (95% CI=18.18-29.13) months. The mass size of the survived and dead groups was 9.2±3.82 cm and 10.84±4.74 cm, respectively. The production rate of adrenal hormone was higher in the dead group (p<0.01; 80%). Moreover, the DHEA-S level and SUVmax values were statistically significantly higher in the dead group (p<0.001; p<0.05, respectively). Although no metastases were observed in the survived group during follow-ups after the operation, distant metastases were observed in 8 people from the dead group (53%; p<0.05). Conclusion: The mortality rate was very high in ACC despite surgical and medical treatments. The higher DHEA-S and SUVmax values may indicate that the overall survival duration was low.
{"title":"Factors Affecting Survival in Adrenocortical Cancers: Single-Center Experience","authors":"M. Güven, Mehmet Şimşek, A. Tuzcu","doi":"10.25179/tjem.2020-74861","DOIUrl":"https://doi.org/10.25179/tjem.2020-74861","url":null,"abstract":"Objective: Adrenocortical cancer (ACC) is one of the rare endocrine system cancers that are aggressive. Despite surgical treatment, the mortality rate is quite high. This study aimed to examine prognostic factors affecting survival in patients with ACC, the role of dehydroepiandrosterone sulfate (DHEA-S), and the maximum standard uptake (SUVmax) values on predicting mortality through the single-center data. Material and Methods: A total of 21 patients who were diagnosed with adrenal cancer and followed from a single center were included in the study. Patients who survived follow-ups were included in the survived group (n=6), and those who died were included in the dead group (n=15). The demographic, anatomical, pathological, and clinical characteristics of the patients were analyzed. Positron emission tomography-computerized tomography imaging and SUVmax values of adrenal masses were compared. The effect of all these data on survival was examined. Results: The mortality rate among patients with ACC was 71%. According to the Kaplan-Meier survival analysis, the average life expectancy was 23.66±2.79 (95% CI=18.18-29.13) months. The mass size of the survived and dead groups was 9.2±3.82 cm and 10.84±4.74 cm, respectively. The production rate of adrenal hormone was higher in the dead group (p<0.01; 80%). Moreover, the DHEA-S level and SUVmax values were statistically significantly higher in the dead group (p<0.001; p<0.05, respectively). Although no metastases were observed in the survived group during follow-ups after the operation, distant metastases were observed in 8 people from the dead group (53%; p<0.05). Conclusion: The mortality rate was very high in ACC despite surgical and medical treatments. The higher DHEA-S and SUVmax values may indicate that the overall survival duration was low.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"11 1","pages":"221-229"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88658085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-74444
I. Sari, A. Altinova, C. Ozkan, M. Akturk, Ceyla Konca Değertekin, E. T. Cerit, M. Yalçın, F. Törüner, A. Karakoc, I. Yetkin, G. Ayvaz, N. Çakır
Turkish and English summaries of the manuscript should take place in a manner that it will not exceed 250 words. The keywords should be written at the end of the summary. The references should not be cited in the summary section. As far as possible, use of abbreviations is to be avoided. If any abbreviations are used, they must be taken into consideration independently of the abbreviations used in the text. The summary should be written with four running titles. Purpose: The goal of the study should be clearly stated. Material and Method: The study should be defined, the standard criteria; it should be also indicated whether the study is randomized or not, whether it is retrospective or prospective, the statistical method, if any, should be indicated. Results (Findings): The detailed result of the study should be given and the statistical significance level should be indicated. OF TURKEY JOURNAL OF THE SOCIETY OF END ABOLISM OCRINOLOGY AND MET
{"title":"Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus","authors":"I. Sari, A. Altinova, C. Ozkan, M. Akturk, Ceyla Konca Değertekin, E. T. Cerit, M. Yalçın, F. Törüner, A. Karakoc, I. Yetkin, G. Ayvaz, N. Çakır","doi":"10.25179/tjem.2020-74444","DOIUrl":"https://doi.org/10.25179/tjem.2020-74444","url":null,"abstract":"Turkish and English summaries of the manuscript should take place in a manner that it will not exceed 250 words. The keywords should be written at the end of the summary. The references should not be cited in the summary section. As far as possible, use of abbreviations is to be avoided. If any abbreviations are used, they must be taken into consideration independently of the abbreviations used in the text. The summary should be written with four running titles. Purpose: The goal of the study should be clearly stated. Material and Method: The study should be defined, the standard criteria; it should be also indicated whether the study is randomized or not, whether it is retrospective or prospective, the statistical method, if any, should be indicated. Results (Findings): The detailed result of the study should be given and the statistical significance level should be indicated. OF TURKEY JOURNAL OF THE SOCIETY OF END ABOLISM OCRINOLOGY AND MET","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"63 1","pages":"109-114"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90739851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.25179/tjem.2020-77613
F. Esfahanian, Seyedeh Mahdieh Fotouk Kiaie, Roghayeh Ghelich, Z. Jadali
Introduction Hashimoto’s thyroiditis (HT) is characterized by diffuse lymphocytic infiltration of the thyroid gland and elevated level of antithyroidspecific autoantibodies. It is more prevalent among women, and its incidence has increased significantly in recent years (1). Although autoimmunity plays a pivotal role in Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among different markers of oxidative damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure the level of 8-OHdG in the sera of patients with HT and healthy control (HC) participants. Material and Methods: In this study, patients were diagnosed with clinical (n=23) and subclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measured using enzyme-linked immunosorbent assay in patients and HC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patients and HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of 8-OHdG is a biomarker of oxidative stress in patients with HT. However, more detailed studies are needed to reveal the exact role of 8-OHdG in this autoimmune disease of the thyroid gland.
{"title":"Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis","authors":"F. Esfahanian, Seyedeh Mahdieh Fotouk Kiaie, Roghayeh Ghelich, Z. Jadali","doi":"10.25179/tjem.2020-77613","DOIUrl":"https://doi.org/10.25179/tjem.2020-77613","url":null,"abstract":"Introduction Hashimoto’s thyroiditis (HT) is characterized by diffuse lymphocytic infiltration of the thyroid gland and elevated level of antithyroidspecific autoantibodies. It is more prevalent among women, and its incidence has increased significantly in recent years (1). Although autoimmunity plays a pivotal role in Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among different markers of oxidative damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure the level of 8-OHdG in the sera of patients with HT and healthy control (HC) participants. Material and Methods: In this study, patients were diagnosed with clinical (n=23) and subclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measured using enzyme-linked immunosorbent assay in patients and HC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patients and HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of 8-OHdG is a biomarker of oxidative stress in patients with HT. However, more detailed studies are needed to reveal the exact role of 8-OHdG in this autoimmune disease of the thyroid gland.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"18 1","pages":"321-326"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90857336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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