Pub Date : 2019-10-24DOI: 10.1097/IJ9.0000000000000076
C. Cui, Xieqiao Yan, Shusen Liu, A. Deitz, L. Si, Z. Chi, X. Sheng, B. Lian, Jian-fang Li, J. Ge, Xuan Wang, L. Mao, B. Tang, Li Zhou, X. Bai, Si-ming Li, Ben Li, Haiyan Wu, Jun Guo
Introduction: Treatment options for advanced melanoma in China are lacking, particularly second-line therapies. The aim of this retrospective observational study was to describe the real-world effectiveness of available anticancer therapies in patients with locally advanced/metastatic melanoma in China. Methods: Adult patients with unresectable stage III or IV melanoma treated between January 1, 2014, and December 31, 2015, at the Beijing Cancer Hospital (BCH) were eligible (data cutoff: December 31, 2017). Data were obtained from patient electronic medical records. Responders were adjudicated per Response Evaluation Criteria in Solid Tumors, version 1.1. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Results: Of 248 eligible patients, 221 and 116 were treated with anticancer therapies in first-line and second-line settings, respectively (89 received both at BCH). Approximately 95% of patients had stage IV melanoma; 40.7% had acral melanoma, and 30.6% had mucosal histology. By data cutoff, 195 of 248 (78.6%) patients had died. Median OS for all patients was 10.5 months; 12-month OS rate was 43.9%. In the first-line setting, the objective response rate was 6.3% (95% confidence interval, 3.5%–10.4%) and the median duration of response was 9.1 months. Median PFS was 3.5 months and 12-month PFS rate was 10.6%; median OS was 10.5 months and 12-month OS rate was 43.5%. In the second-line setting, objective response rate was 3.4% (95% confidence interval, 0.9%–8.6%) and median duration of response was 7.5 months. Median PFS was 2.3 months and 12-month PFS rate was 5.2%; median OS was 7.5 months and 12-month OS rate was 30.5%. Conclusion: In China, first-line and second-line anticancer therapy seems to be associated with suboptimal clinical outcomes in advanced melanoma, indicating a need for effective therapies.
{"title":"Real-world clinical outcomes of anticancer treatments in patients with advanced melanoma in China: retrospective, observational study","authors":"C. Cui, Xieqiao Yan, Shusen Liu, A. Deitz, L. Si, Z. Chi, X. Sheng, B. Lian, Jian-fang Li, J. Ge, Xuan Wang, L. Mao, B. Tang, Li Zhou, X. Bai, Si-ming Li, Ben Li, Haiyan Wu, Jun Guo","doi":"10.1097/IJ9.0000000000000076","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000076","url":null,"abstract":"Introduction: Treatment options for advanced melanoma in China are lacking, particularly second-line therapies. The aim of this retrospective observational study was to describe the real-world effectiveness of available anticancer therapies in patients with locally advanced/metastatic melanoma in China. Methods: Adult patients with unresectable stage III or IV melanoma treated between January 1, 2014, and December 31, 2015, at the Beijing Cancer Hospital (BCH) were eligible (data cutoff: December 31, 2017). Data were obtained from patient electronic medical records. Responders were adjudicated per Response Evaluation Criteria in Solid Tumors, version 1.1. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Results: Of 248 eligible patients, 221 and 116 were treated with anticancer therapies in first-line and second-line settings, respectively (89 received both at BCH). Approximately 95% of patients had stage IV melanoma; 40.7% had acral melanoma, and 30.6% had mucosal histology. By data cutoff, 195 of 248 (78.6%) patients had died. Median OS for all patients was 10.5 months; 12-month OS rate was 43.9%. In the first-line setting, the objective response rate was 6.3% (95% confidence interval, 3.5%–10.4%) and the median duration of response was 9.1 months. Median PFS was 3.5 months and 12-month PFS rate was 10.6%; median OS was 10.5 months and 12-month OS rate was 43.5%. In the second-line setting, objective response rate was 3.4% (95% confidence interval, 0.9%–8.6%) and median duration of response was 7.5 months. Median PFS was 2.3 months and 12-month PFS rate was 5.2%; median OS was 7.5 months and 12-month OS rate was 30.5%. Conclusion: In China, first-line and second-line anticancer therapy seems to be associated with suboptimal clinical outcomes in advanced melanoma, indicating a need for effective therapies.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"115 1","pages":"e76 - e76"},"PeriodicalIF":0.3,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77549607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-18DOI: 10.1097/ij9.0000000000000078
T. König, O. Muensterer
According to the World Health Organization, the global decrease of physical activity is one of the leading causes of mortality worldwide, resulting not only in cardiopulmonary disease and obesity, but also in a predisposition for the development of cancer [1] . This article gives an up-date perspective on the impact of sedentary behavior and exercise on cancer development, course of treatment, as well as secondary prevention in cancer survivors. colorectal and is clear in large epidemiological series, risk reduction
{"title":"Sedentary behavior, exercise, and cancer development","authors":"T. König, O. Muensterer","doi":"10.1097/ij9.0000000000000078","DOIUrl":"https://doi.org/10.1097/ij9.0000000000000078","url":null,"abstract":"According to the World Health Organization, the global decrease of physical activity is one of the leading causes of mortality worldwide, resulting not only in cardiopulmonary disease and obesity, but also in a predisposition for the development of cancer [1] . This article gives an up-date perspective on the impact of sedentary behavior and exercise on cancer development, course of treatment, as well as secondary prevention in cancer survivors. colorectal and is clear in large epidemiological series, risk reduction","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"51 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76811620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.1097/IJ9.0000000000000077
Jan Goedeke, O. Muensterer
Being overweight has been a long-known peril to health, and scientists were able to show a relationship between body fat and cancer years ago. Of course, not every obese individual will inevitably develop cancer, but recent scientific studies show that excessive body fat has an impact on a much broader spectrum of cancers than previously thought. This applies to adults as well as children and adolescents. In 2015, the Organisation for Economic Co-operation and Development (OECD) reported that already > 50%of adults and nearly 30% of teenagers in 34 member countries were considered overweight (body mass index, BMI ≥ 25 kg/m2 body surface area), or even obese (BMI ≥30 kg/m2 body surface area). The tendency increased gradually in all countries over a period of 25 years (1990–2015).We therefore have to expect steadily rising numbers of cancers worldwide solely due to obesity in the future. A population-based study using BMI and cancer incidence data from the GLOBOCAN project estimated that, in 2012 in the United States, about 28,000 new cases of cancer in men (3.5%) and 72,000 in women (9.5%) were due to overweight or obesity. The percentage of cases attributed to overweight or obesity varied widely for different cancer types but was as high as 54% for gallbladder cancer in women and 44% for esophageal adenocarcinoma in men. The International Agency for Research on Cancer (IARC) as part of the World Health Organization (WHO) in 2016 reported an increased risk of cancer for at least 13 cancer types [colon cancer, esophageal cancer, renal carcinoma, uterine cancer, breast cancer (during and after menopause; also in men), liver cancer, pancreatic cancer, gall bladder cancer, ovarian cancer, gastric cancer, thyroid cancer, multiple myeloma, and meningioma]. For some of these cancers, the experts even found a dose-response relationship, implying that the risk of cancer increases with BMI. Currently, there are many theories that could explain the increased incidence of cancer in obesity. The preponderance of the evidence suggests that a combination of different factors might be responsible. However, it should be reiterated that there is no direct link between obesity and the development of cancer. On the one hand, obesity seems to cause a general hormonal imbalance including hyperinsulinemia and an increase in insulinlike growth factors, as well as sex hormones. In addition, hyperplastic and hypertrophic white adipose tissue (especially visceral adipose tissue) acts as an independent active endocrine organ releasing immunologically active adipokines and other hormones. These hormonal imbalances support cell growth– promoting processes. On the other hand, obesity is associated with a state of low-grade chronic inflammation. Insulin resistance and the metabolic syndrome are associated with higher circulating concentrations of inflammation-related markers, including leptin, interleukin-6, and tumor necrosis factor, many of which have been shown to enhance tum
{"title":"The role of obesity in cancer development","authors":"Jan Goedeke, O. Muensterer","doi":"10.1097/IJ9.0000000000000077","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000077","url":null,"abstract":"Being overweight has been a long-known peril to health, and scientists were able to show a relationship between body fat and cancer years ago. Of course, not every obese individual will inevitably develop cancer, but recent scientific studies show that excessive body fat has an impact on a much broader spectrum of cancers than previously thought. This applies to adults as well as children and adolescents. In 2015, the Organisation for Economic Co-operation and Development (OECD) reported that already > 50%of adults and nearly 30% of teenagers in 34 member countries were considered overweight (body mass index, BMI ≥ 25 kg/m2 body surface area), or even obese (BMI ≥30 kg/m2 body surface area). The tendency increased gradually in all countries over a period of 25 years (1990–2015).We therefore have to expect steadily rising numbers of cancers worldwide solely due to obesity in the future. A population-based study using BMI and cancer incidence data from the GLOBOCAN project estimated that, in 2012 in the United States, about 28,000 new cases of cancer in men (3.5%) and 72,000 in women (9.5%) were due to overweight or obesity. The percentage of cases attributed to overweight or obesity varied widely for different cancer types but was as high as 54% for gallbladder cancer in women and 44% for esophageal adenocarcinoma in men. The International Agency for Research on Cancer (IARC) as part of the World Health Organization (WHO) in 2016 reported an increased risk of cancer for at least 13 cancer types [colon cancer, esophageal cancer, renal carcinoma, uterine cancer, breast cancer (during and after menopause; also in men), liver cancer, pancreatic cancer, gall bladder cancer, ovarian cancer, gastric cancer, thyroid cancer, multiple myeloma, and meningioma]. For some of these cancers, the experts even found a dose-response relationship, implying that the risk of cancer increases with BMI. Currently, there are many theories that could explain the increased incidence of cancer in obesity. The preponderance of the evidence suggests that a combination of different factors might be responsible. However, it should be reiterated that there is no direct link between obesity and the development of cancer. On the one hand, obesity seems to cause a general hormonal imbalance including hyperinsulinemia and an increase in insulinlike growth factors, as well as sex hormones. In addition, hyperplastic and hypertrophic white adipose tissue (especially visceral adipose tissue) acts as an independent active endocrine organ releasing immunologically active adipokines and other hormones. These hormonal imbalances support cell growth– promoting processes. On the other hand, obesity is associated with a state of low-grade chronic inflammation. Insulin resistance and the metabolic syndrome are associated with higher circulating concentrations of inflammation-related markers, including leptin, interleukin-6, and tumor necrosis factor, many of which have been shown to enhance tum","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"434 1","pages":"e77 - e77"},"PeriodicalIF":0.3,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85754968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/ij9.0000000000000075
I. Janmohamed
{"title":"A medical student’s reflection on intercalation","authors":"I. Janmohamed","doi":"10.1097/ij9.0000000000000075","DOIUrl":"https://doi.org/10.1097/ij9.0000000000000075","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"47 10 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77289380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1097/IJ9.0000000000000071
Shahryar Noordin, T. Ahmad, M. Umer, S. Allana, Kiran Hilal, N. Uddin, P. Hashmi
{"title":"Aneurysmal bone cyst of the pelvis and extremities: Contemporary\u0000 management","authors":"Shahryar Noordin, T. Ahmad, M. Umer, S. Allana, Kiran Hilal, N. Uddin, P. Hashmi","doi":"10.1097/IJ9.0000000000000071","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000071","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"8 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84781086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}