Pub Date : 2020-05-11DOI: 10.1097/IJ9.0000000000000088
Zhen Gao, S.H. Chang
A 6-year-old boy presented with a 5-year history of pigmentation on the face, neck, and hands. On examination, the patient had extreme photophobia. There was multiple freckles-like pigmentations on the face, neck, and back of both hands. Extremities were densely distributed. Multiple facial lesions, 1–2 cm2 in size, were also seen; most of them were ulcerated and had crusty patches. There was mild double eversion of the lower eyelids, with pigmentation and conjunctival redness in both eyes. Facial histopathologic findings: Spitz nevus-like malignant melanoma, Clark grade IV. A final diagnosis of melanoma secondary to xeroderma pigmentosa was made. According to the previous literature, the minimum age of patients with xeroderma pigmentosum combined with malignant melanoma is 8 years old, but the age, in this case, is 6 years old. In addition, extensive local excision of suspicious lesions early is of great significance for the prognosis of patients.
{"title":"Spitz melanoma secondary to xeroderma pigmentosa in a child: a case report","authors":"Zhen Gao, S.H. Chang","doi":"10.1097/IJ9.0000000000000088","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000088","url":null,"abstract":"A 6-year-old boy presented with a 5-year history of pigmentation on the face, neck, and hands. On examination, the patient had extreme photophobia. There was multiple freckles-like pigmentations on the face, neck, and back of both hands. Extremities were densely distributed. Multiple facial lesions, 1–2 cm2 in size, were also seen; most of them were ulcerated and had crusty patches. There was mild double eversion of the lower eyelids, with pigmentation and conjunctival redness in both eyes. Facial histopathologic findings: Spitz nevus-like malignant melanoma, Clark grade IV. A final diagnosis of melanoma secondary to xeroderma pigmentosa was made. According to the previous literature, the minimum age of patients with xeroderma pigmentosum combined with malignant melanoma is 8 years old, but the age, in this case, is 6 years old. In addition, extensive local excision of suspicious lesions early is of great significance for the prognosis of patients.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84941800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-06DOI: 10.1097/IJ9.0000000000000087
A. Thorn, M. Harving, G. Lausten, J. Johansen, M. S. Sørensen, M. Petersen
Purpose: YKL-40 is a glycoprotein with a role in inflammation, tissue remodeling, tumor angiogenesis, and protection against apoptosis. We hypothesized that high preoperative plasma YKL-40 in patients with nonmetastatic bone and soft tissue sarcoma (STS) is associated with short overall survival (OS), and that plasma YKL-40 is an independent predictor for OS. Materials and methods: Plasma was collected preoperatively from 65 patients with nonmetastatic bone (n=14) or STS (n=51) in the lower extremities (n=43), the upper extremities (n=16) or the trunk wall/spine (n=6). All patients underwent surgical cancer treatment. Twenty patients developed metastases during the follow-up period (minimum 5 y). The plasma concentration of YKL-40 was determined by enzyme-linked immunosorbent assay. Results: Twenty-seven patients died [mean: 3.2 (range: 0.2–7.3) y postoperatively] and 38 patients were still alive after a follow-up of mean 6.9 (5.8–8.2) years postoperatively. Plasma YKL-40 was higher in patients who died during follow-up (P=0.008), in males (P=0.007) and in patients 61 years of age and above (P=0.001). The 5-year OS was 68% and OS was lower in patients with high (≥95% percentile age-corrected) plasma YKL-40 (P=0.021), age 61 years and above (P=0.013), high histologic malignancy grade (P=0.047) and male sex (P=0.051). Multivariable analysis showed that only plasma YKL-40 (age-corrected (hazard ratio=2.80, 95% confidence interval: 1.13–6.91, P=0.026) and malignancy grade (hazard ratio=9.9×107, 95% confidence interval: 0–∞, P=0.007) remained independent prognostic factors for OS. Conclusions: High preoperative plasma YKL-40 was related to short OS in patients with nonmetastatic bone and STS and plasma YKL-40 (age-corrected) was an independent prognostic risk factor for OS.
{"title":"Plasma YKL-40 as a biomarker in patients with nonmetastatic bone and soft tissue sarcomas: a prospective exploratory clinical study","authors":"A. Thorn, M. Harving, G. Lausten, J. Johansen, M. S. Sørensen, M. Petersen","doi":"10.1097/IJ9.0000000000000087","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000087","url":null,"abstract":"Purpose: YKL-40 is a glycoprotein with a role in inflammation, tissue remodeling, tumor angiogenesis, and protection against apoptosis. We hypothesized that high preoperative plasma YKL-40 in patients with nonmetastatic bone and soft tissue sarcoma (STS) is associated with short overall survival (OS), and that plasma YKL-40 is an independent predictor for OS. Materials and methods: Plasma was collected preoperatively from 65 patients with nonmetastatic bone (n=14) or STS (n=51) in the lower extremities (n=43), the upper extremities (n=16) or the trunk wall/spine (n=6). All patients underwent surgical cancer treatment. Twenty patients developed metastases during the follow-up period (minimum 5 y). The plasma concentration of YKL-40 was determined by enzyme-linked immunosorbent assay. Results: Twenty-seven patients died [mean: 3.2 (range: 0.2–7.3) y postoperatively] and 38 patients were still alive after a follow-up of mean 6.9 (5.8–8.2) years postoperatively. Plasma YKL-40 was higher in patients who died during follow-up (P=0.008), in males (P=0.007) and in patients 61 years of age and above (P=0.001). The 5-year OS was 68% and OS was lower in patients with high (≥95% percentile age-corrected) plasma YKL-40 (P=0.021), age 61 years and above (P=0.013), high histologic malignancy grade (P=0.047) and male sex (P=0.051). Multivariable analysis showed that only plasma YKL-40 (age-corrected (hazard ratio=2.80, 95% confidence interval: 1.13–6.91, P=0.026) and malignancy grade (hazard ratio=9.9×107, 95% confidence interval: 0–∞, P=0.007) remained independent prognostic factors for OS. Conclusions: High preoperative plasma YKL-40 was related to short OS in patients with nonmetastatic bone and STS and plasma YKL-40 (age-corrected) was an independent prognostic risk factor for OS.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81894100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.1097/IJ9.0000000000000086
J. Kodiyan, M. Ashamalla, A. Guirguis, H. Ashamalla
Supplemental Digital Content is available in the text. Introduction: It is commonly held that race serves as a significant prognosticator in prostate cancer. We sought to analyze whether race impacted overall survival (OS) of men receiving standard of care treatment. Materials and Methods: All data was obtained from the NCDB (National Cancer Database) and initially contained 1,294,126 cases of prostate cancer diagnosed between 2004 and 2013. Patients were excluded if they had metastatic or nodal disease, received chemotherapy, or had noninvasive disease. Patients were grouped into 2 cohorts as per NCCN (National Comprehensive Cancer Network) criteria: favorable risk and unfavorable risk. All patients received risk-appropriate radiation therapy or surgery, and were subsequently analyzed. Black and white men were also matched 1:1 within each risk cohort using propensity scores, and multivariate analysis was conducted on these matched cohorts. Results: The final cohort 77,448 patients. Median follow-up 58.7 months (range, 48–143.5). In the favorable risk cohort, white men had superior OS compared with black men, 77.63% versus 80.57% at 10 years (hazard ratio, 0.644; 95% confidence interval, 0.536–0.773; P<0.001). In the unfavorable cohort, race was not a significant prognostic factor for OS on unmatched analysis; 10-year survival 73.6% and 71.3% (hazard ratio, 0.941; 95% confidence interval, 0.848–1.044; P=0.249), and significant interaction existed with age. Results were unchanged in propensity score matched cohorts. Conclusion: The prognostic value of race-related biological differences of prostate cancer may hold less value in higher risk disease than is commonly believed.
{"title":"Race is not prognostic in unfavorable prostate cancer: an NCDB analysis","authors":"J. Kodiyan, M. Ashamalla, A. Guirguis, H. Ashamalla","doi":"10.1097/IJ9.0000000000000086","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000086","url":null,"abstract":"Supplemental Digital Content is available in the text. Introduction: It is commonly held that race serves as a significant prognosticator in prostate cancer. We sought to analyze whether race impacted overall survival (OS) of men receiving standard of care treatment. Materials and Methods: All data was obtained from the NCDB (National Cancer Database) and initially contained 1,294,126 cases of prostate cancer diagnosed between 2004 and 2013. Patients were excluded if they had metastatic or nodal disease, received chemotherapy, or had noninvasive disease. Patients were grouped into 2 cohorts as per NCCN (National Comprehensive Cancer Network) criteria: favorable risk and unfavorable risk. All patients received risk-appropriate radiation therapy or surgery, and were subsequently analyzed. Black and white men were also matched 1:1 within each risk cohort using propensity scores, and multivariate analysis was conducted on these matched cohorts. Results: The final cohort 77,448 patients. Median follow-up 58.7 months (range, 48–143.5). In the favorable risk cohort, white men had superior OS compared with black men, 77.63% versus 80.57% at 10 years (hazard ratio, 0.644; 95% confidence interval, 0.536–0.773; P<0.001). In the unfavorable cohort, race was not a significant prognostic factor for OS on unmatched analysis; 10-year survival 73.6% and 71.3% (hazard ratio, 0.941; 95% confidence interval, 0.848–1.044; P=0.249), and significant interaction existed with age. Results were unchanged in propensity score matched cohorts. Conclusion: The prognostic value of race-related biological differences of prostate cancer may hold less value in higher risk disease than is commonly believed.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76458063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.1097/IJ9.0000000000000085
S. Saha, Sha Yao, O. Elakad, Anna-Maria Lois, H. Henric-Petri, J. Buentzel, M. Hinterthaner, B. Danner, P. Ströbel, A. Emmert, H. Bohnenberger
Supplemental Digital Content is available in the text. Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels of UGDH have been linked to the progression of epithelial cancers, such as those of the breast, colon and prostate. Therefore we aimed to analyze if the expression level of UGDH does also influence patients survival of lung cancer patients. Methods: UGDH expression levels were analyzed by immunohistochemistry in 96 samples of pulmonary adenocarcinoma (AC), 84 cases of squamous cell lung carcinoma (SQCLC) and 33 samples of small cell lung cancer (SCLC) and correlated with clinicopathologic characteristics and patient outcome. Results: UGDH was expressed in 62.5% cases of AC, 70.2% cases of SQCLC, and 48.5% cases of SCLC. In AC, expression of UGDH was significantly associated with lymph node metastasis and worse overall survival of the affected patients. However, UGDH expression had no significant correlation to prognosis in SQCLC or SCLC patients. Conclusions: In our study, expression of UGDH was associated with worse prognosis of patients with pulmonary adenocarcinoma so that expression of UGDH might help to guide treatment decisions. Furthermore, UGDH might present a potential novel drug target in AC as it displays inhibitable catalytic activity.
{"title":"UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma","authors":"S. Saha, Sha Yao, O. Elakad, Anna-Maria Lois, H. Henric-Petri, J. Buentzel, M. Hinterthaner, B. Danner, P. Ströbel, A. Emmert, H. Bohnenberger","doi":"10.1097/IJ9.0000000000000085","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000085","url":null,"abstract":"Supplemental Digital Content is available in the text. Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels of UGDH have been linked to the progression of epithelial cancers, such as those of the breast, colon and prostate. Therefore we aimed to analyze if the expression level of UGDH does also influence patients survival of lung cancer patients. Methods: UGDH expression levels were analyzed by immunohistochemistry in 96 samples of pulmonary adenocarcinoma (AC), 84 cases of squamous cell lung carcinoma (SQCLC) and 33 samples of small cell lung cancer (SCLC) and correlated with clinicopathologic characteristics and patient outcome. Results: UGDH was expressed in 62.5% cases of AC, 70.2% cases of SQCLC, and 48.5% cases of SCLC. In AC, expression of UGDH was significantly associated with lymph node metastasis and worse overall survival of the affected patients. However, UGDH expression had no significant correlation to prognosis in SQCLC or SCLC patients. Conclusions: In our study, expression of UGDH was associated with worse prognosis of patients with pulmonary adenocarcinoma so that expression of UGDH might help to guide treatment decisions. Furthermore, UGDH might present a potential novel drug target in AC as it displays inhibitable catalytic activity.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81442104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Palbociclib resistance is a significant problem in breast carcinoma, and its underlying molecular mechanisms remain poorly understood. This study aims to elucidate the molecular mechanisms of palbociclib resistance and to identify the key genes and pathways mediating progesterone resistance in breast cancer (BC). Methods: Gene dataset GSE117743 was downloaded from the Gene Expression Omnibus (GEO) database, which included 3 palbociclib-resistant and 3 palbociclib-sensitive BC cell lines. Then, we calculated the differentially expressed genes (DEGs) by using R software. Gene ontology and Enriched pathway analysis of genes we identified were analyzed by using the Database for Database of Annotation Visualization and Integrated Discovery (DAVID) and R software. The protein-protein interaction network was performed according to Metascape, String, and Cytoscape software. Results: In total, 447 DEGs were selected, which consisted of 67 upregulated and 380 downregulated genes. According to gene ontology annotation, DEGs were associated with cytoplasm, signal transduction, and protein binding. The research of the Kyoto Encyclopedia of Genes and Genomes (KEGG) demonstrated that genes enriched in certain tumor pathways, including IL-17 signaling pathways and Herpes simplex infection signaling pathways. Also, certain hub genes were highlighted after constructed and analyzed the protein-protein interaction network, including α-2A adrenergic receptor, cytochrome P450 subfamily IIR polypeptide, Cystathionine β-synthase, nucleotide-binding oligomerization domain-containing, erythropoietin-producing hepatocellular receptor A2 and adrenomedullin, which may be related with BC prognosis. A total of 4 of 6 hub genes had a significant relationship with the overall survival (P<0.05). Conclusions: Using microarray and bioinformatics analyses, we identified DEGs and determined a comprehensive gene network of progesterone resistance. We offered several possible mechanisms of progesterone resistance and identified therapeutic and prognostic targets of palbociclib resistance in BC.
背景:帕博西尼耐药是乳腺癌中的一个重要问题，其潜在的分子机制尚不清楚。本研究旨在阐明帕博西尼耐药的分子机制，确定乳腺癌(BC)中介导孕酮耐药的关键基因和途径。方法:从Gene Expression Omnibus (GEO)数据库下载基因数据集GSE117743，其中包括3株palbociclib耐药和3株palbociclib敏感的BC细胞株。然后利用R软件计算差异表达基因(DEGs)。利用DAVID (Database for Database of Annotation Visualization and Integrated Discovery)和R软件对所鉴定基因的基因本体和富集通路进行分析。蛋白-蛋白相互作用网络根据metscape, String和Cytoscape软件进行。结果:共筛选到447个基因，其中上调基因67个，下调基因380个。根据基因本体注释，deg与细胞质、信号转导和蛋白质结合有关。京都基因与基因组百科全书(KEGG)的研究表明，基因在某些肿瘤通路中富集，包括IL-17信号通路和单纯疱疹感染信号通路。构建并分析了蛋白-蛋白相互作用网络后，突出了α-2A肾上腺素能受体、细胞色素P450亚家族IIR多肽、胱硫氨酸β-合成酶、核苷酸结合寡聚结构域、促红细胞生成素肝细胞受体A2、肾上腺髓质素等可能与BC预后相关的枢纽基因。6个枢纽基因中有4个与总生存率有显著相关(P<0.05)。结论:利用微阵列和生物信息学分析，我们鉴定了deg，并确定了黄体酮耐药的综合基因网络。我们提出了几种可能的孕酮耐药机制，并确定了BC患者帕博西尼耐药的治疗和预后靶点。
{"title":"Identification of key genes and their functions in palbociclib-resistant breast carcinoma by using bioinformatics analysis","authors":"Guangyu Gao, Xinya Shi, Zhen Yao, Jiaofeng Shen, Liqin Shen","doi":"10.1097/IJ9.0000000000000084","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000084","url":null,"abstract":"Background: Palbociclib resistance is a significant problem in breast carcinoma, and its underlying molecular mechanisms remain poorly understood. This study aims to elucidate the molecular mechanisms of palbociclib resistance and to identify the key genes and pathways mediating progesterone resistance in breast cancer (BC). Methods: Gene dataset GSE117743 was downloaded from the Gene Expression Omnibus (GEO) database, which included 3 palbociclib-resistant and 3 palbociclib-sensitive BC cell lines. Then, we calculated the differentially expressed genes (DEGs) by using R software. Gene ontology and Enriched pathway analysis of genes we identified were analyzed by using the Database for Database of Annotation Visualization and Integrated Discovery (DAVID) and R software. The protein-protein interaction network was performed according to Metascape, String, and Cytoscape software. Results: In total, 447 DEGs were selected, which consisted of 67 upregulated and 380 downregulated genes. According to gene ontology annotation, DEGs were associated with cytoplasm, signal transduction, and protein binding. The research of the Kyoto Encyclopedia of Genes and Genomes (KEGG) demonstrated that genes enriched in certain tumor pathways, including IL-17 signaling pathways and Herpes simplex infection signaling pathways. Also, certain hub genes were highlighted after constructed and analyzed the protein-protein interaction network, including α-2A adrenergic receptor, cytochrome P450 subfamily IIR polypeptide, Cystathionine β-synthase, nucleotide-binding oligomerization domain-containing, erythropoietin-producing hepatocellular receptor A2 and adrenomedullin, which may be related with BC prognosis. A total of 4 of 6 hub genes had a significant relationship with the overall survival (P<0.05). Conclusions: Using microarray and bioinformatics analyses, we identified DEGs and determined a comprehensive gene network of progesterone resistance. We offered several possible mechanisms of progesterone resistance and identified therapeutic and prognostic targets of palbociclib resistance in BC.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83260574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.1097/IJ9.0000000000000083
Z. Chen, S. Fu, Minghui Li, Wei Zhang, Huilong Ou
In this study, a laser-induced auto-fluorescence (LIAF) system combined with the artificial neural network (ANN) algorithm is developed for early detection of human upper gastrointestinal tract carcinoma in vivo, through investigating the LIAF spectrum characteristics of the normal mucosa layer and the changes concerning an abnormal surface. Of the 44 participating patients, 41 underwent biopsy at the abnormal surface area at endoscopy. The ANN is employed to differentiate the LIAF data obtained from the normal and carcinoma patients (according to biopsy pathology diagnosis). The LIAF spectrum between 500 and 700 nm is selected and normalized. One data point is selected every 10 nm. A feed-forward back-propagation network with 2 hidden layers is constructed and trained. To evaluate the performance of ANN, 10 normal and 10 carcinoma data sets are tested with the trained ANN. 100% of the carcinoma data are very close to −1 (desired), 80% of the normal surface is very close to 1 (desired), and 20% return values around −0.28. Previous works on this type of ANN suggested a threshold of −0.5. As a result, all normal data are successful and the carcinoma cases are accurately classified and diagnosed. In conclusion, the LIAF technology combined with ANN diagnosis is more accurate.
{"title":"Exploring artificial neural network combined with laser-induced auto-fluorescence technology for noninvasive in vivo upper gastrointestinal tract cancer early diagnosis","authors":"Z. Chen, S. Fu, Minghui Li, Wei Zhang, Huilong Ou","doi":"10.1097/IJ9.0000000000000083","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000083","url":null,"abstract":"In this study, a laser-induced auto-fluorescence (LIAF) system combined with the artificial neural network (ANN) algorithm is developed for early detection of human upper gastrointestinal tract carcinoma in vivo, through investigating the LIAF spectrum characteristics of the normal mucosa layer and the changes concerning an abnormal surface. Of the 44 participating patients, 41 underwent biopsy at the abnormal surface area at endoscopy. The ANN is employed to differentiate the LIAF data obtained from the normal and carcinoma patients (according to biopsy pathology diagnosis). The LIAF spectrum between 500 and 700 nm is selected and normalized. One data point is selected every 10 nm. A feed-forward back-propagation network with 2 hidden layers is constructed and trained. To evaluate the performance of ANN, 10 normal and 10 carcinoma data sets are tested with the trained ANN. 100% of the carcinoma data are very close to −1 (desired), 80% of the normal surface is very close to 1 (desired), and 20% return values around −0.28. Previous works on this type of ANN suggested a threshold of −0.5. As a result, all normal data are successful and the carcinoma cases are accurately classified and diagnosed. In conclusion, the LIAF technology combined with ANN diagnosis is more accurate.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77563653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-03DOI: 10.1097/ij9.0000000000000082
N. None
{"title":"A medical student’s reflection on intercalation: retraction","authors":"N. None","doi":"10.1097/ij9.0000000000000082","DOIUrl":"https://doi.org/10.1097/ij9.0000000000000082","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86414399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.1097/IJ9.0000000000000081
Lin Han, Zhen Wu, Wen-lei Li, Yingxue Li, Jin-Quan Ma, Xinxin Wu, Wenjuan Wen, Rui Li, Yu-min Yao, Yongkun Wang
Summary: The incidence of thyroid cancer has increased year by year, which has a major impact on the physical and mental health of patients. At the same time, it has a heavy psychological and economic burden on society and individuals. Based on the actual data of the thyroid cancer in Liaocheng People’ Hospital in 2017, combine with the national and regional characteristics of China, this paper analyzes and discusses the controversy of initial thyroid operation modus. Materials and methods: The clinical and pathologic data of 552 patients of thyroid cancer were collected from the department of thyroid surgery, who were initially discovered and treated surgically. 40 patients underwent endoscopic surgery, the range of resection was lobectomy+central lymph node dissection of the affected lobe. There were 512 cases underwent open operation with total thyroidectomy+central lymph node dissection, 239 of which were treated with neck lateral lymph node dissection at the same time. Results: The overall metastasis rate of all patients was 59.42%. Even the lymph node metastasis of papillary thyroid microcarcinoma was as high as 46.92%. When the mass rose above 2 cm, the proportion of metastasis increased to 77.53%. When the tumor was complicated with bilateral and multiple high risk factor etc the proportion of metastasis were 63.54% and 71.19%, respectively. Meanwhile, the incidence of contralateral accidental malignancy was 7.25% after postoperative paraffin pathology. Conclusion: The malignant degree of thyroid cancer depends on the evolution of the tumor genome and there is a high rate of neck lymph node metastasis, especially when associated with high risk factors. It is recommended that at least total thyroidectomy+central lymph node dissection should be performed in initial treatment in China to avoid the risk of secondary operation and the burden of body and mind.
{"title":"The real world and thinking of thyroid cancer in China","authors":"Lin Han, Zhen Wu, Wen-lei Li, Yingxue Li, Jin-Quan Ma, Xinxin Wu, Wenjuan Wen, Rui Li, Yu-min Yao, Yongkun Wang","doi":"10.1097/IJ9.0000000000000081","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000081","url":null,"abstract":"Summary: The incidence of thyroid cancer has increased year by year, which has a major impact on the physical and mental health of patients. At the same time, it has a heavy psychological and economic burden on society and individuals. Based on the actual data of the thyroid cancer in Liaocheng People’ Hospital in 2017, combine with the national and regional characteristics of China, this paper analyzes and discusses the controversy of initial thyroid operation modus. Materials and methods: The clinical and pathologic data of 552 patients of thyroid cancer were collected from the department of thyroid surgery, who were initially discovered and treated surgically. 40 patients underwent endoscopic surgery, the range of resection was lobectomy+central lymph node dissection of the affected lobe. There were 512 cases underwent open operation with total thyroidectomy+central lymph node dissection, 239 of which were treated with neck lateral lymph node dissection at the same time. Results: The overall metastasis rate of all patients was 59.42%. Even the lymph node metastasis of papillary thyroid microcarcinoma was as high as 46.92%. When the mass rose above 2 cm, the proportion of metastasis increased to 77.53%. When the tumor was complicated with bilateral and multiple high risk factor etc the proportion of metastasis were 63.54% and 71.19%, respectively. Meanwhile, the incidence of contralateral accidental malignancy was 7.25% after postoperative paraffin pathology. Conclusion: The malignant degree of thyroid cancer depends on the evolution of the tumor genome and there is a high rate of neck lymph node metastasis, especially when associated with high risk factors. It is recommended that at least total thyroidectomy+central lymph node dissection should be performed in initial treatment in China to avoid the risk of secondary operation and the burden of body and mind.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85399287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1097/ij9.0000000000000079
Jiancong Hu, Xiaochuan Chen, D. Lin, Zhaoliang Yu, Juan Li, Xue-feng Guo
{"title":"Neuroendocrine tumor mixed with adenoma in rectum: a case report and\u0000 literature review","authors":"Jiancong Hu, Xiaochuan Chen, D. Lin, Zhaoliang Yu, Juan Li, Xue-feng Guo","doi":"10.1097/ij9.0000000000000079","DOIUrl":"https://doi.org/10.1097/ij9.0000000000000079","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78645374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1097/ij9.0000000000000080
C. S. Kan, T. Chang, Lu Jeat Cheong, Manisah Binti Mohd. Dzin, Saravanan Karupiah, Y. Jong, S. Y. Soon
{"title":"Uncommon presentation of a huge intrathoracic ganglioneuroma in an\u0000 8-year-old child: a rare case report","authors":"C. S. Kan, T. Chang, Lu Jeat Cheong, Manisah Binti Mohd. Dzin, Saravanan Karupiah, Y. Jong, S. Y. Soon","doi":"10.1097/ij9.0000000000000080","DOIUrl":"https://doi.org/10.1097/ij9.0000000000000080","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81928863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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