Pub Date : 2018-05-01DOI: 10.1097/IJ9.0000000000000062
M. Hafeez, A. Malik, Shahryar Noordin
Background: Osteosarcoma or “osteogenic sarcoma” is the most common neoplasm of the bone in children and young adults. This research is premised upon a citation analysis of the top 100 most-cited articles on osteosarcoma. Materials and Methods: This research is dependent upon the use of SCOPUS database. Using the search strategy “osteosarcoma” on this database yielded 12,107 articles. After filtering for relevant articles, the top 100 most-cited articles were retrieved for descriptive and statistical analysis. Results: The most-cited paper was “A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma” by Friend and colleagues published in 1986 with 1888 citations. The publication years ranged from 1967 to 2014. The United States was the most productive country in terms of research output, followed by Italy. Institution-wise, the Memorial Sloan-Kettering Cancer Centre contributed the most articles. However, the most prolific author was from Italy. Majority of the publications were level IV studies Conclusions: Although citation analysis is not entirely flawless, this is a comprehensive list of the top 100 most-cited articles significantly impacting osteosarcoma knowledge and research over time. Future studies need to cater toward maximizing high-quality evidenced articles.
{"title":"The top 100 most-cited articles on osteosarcoma: a bibliometric analysis","authors":"M. Hafeez, A. Malik, Shahryar Noordin","doi":"10.1097/IJ9.0000000000000062","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000062","url":null,"abstract":"Background: Osteosarcoma or “osteogenic sarcoma” is the most common neoplasm of the bone in children and young adults. This research is premised upon a citation analysis of the top 100 most-cited articles on osteosarcoma. Materials and Methods: This research is dependent upon the use of SCOPUS database. Using the search strategy “osteosarcoma” on this database yielded 12,107 articles. After filtering for relevant articles, the top 100 most-cited articles were retrieved for descriptive and statistical analysis. Results: The most-cited paper was “A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma” by Friend and colleagues published in 1986 with 1888 citations. The publication years ranged from 1967 to 2014. The United States was the most productive country in terms of research output, followed by Italy. Institution-wise, the Memorial Sloan-Kettering Cancer Centre contributed the most articles. However, the most prolific author was from Italy. Majority of the publications were level IV studies Conclusions: Although citation analysis is not entirely flawless, this is a comprehensive list of the top 100 most-cited articles significantly impacting osteosarcoma knowledge and research over time. Future studies need to cater toward maximizing high-quality evidenced articles.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"29 1","pages":"e62"},"PeriodicalIF":0.3,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73599093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-01DOI: 10.1097/IJ9.0000000000000058
K. Abbas, A. Siddiqui
Importance: This review provides an in-depth discussion of the different treatment and management strategies adopted for chondrosarcoma, the various outcomes and the prognostic factors of the disease. Chondrosarcoma is the third most common malignant bone tumor after myeloma and osteosarcoma. It is characterized by the production of a cartilaginous matrix by malignant cells. It can be classified according to the source of its origin, histopathologic grade, site of occurrence, and rarity. Chondrosarcomas that are de novo in nature are classified as primary chondrosarcomas, while those derived from pre-existing enchondromas or osteochondromas are regarded as secondary chondrosarcomas. Other rare forms of chondrosarcoma include dedifferentiated, mesenchymal, and clear cell chondrosarcomas. Observations/Findings: Early diagnosis, accurate interpretation of histopathology, precise grading, and careful localization are crucial in the management of chondrosarcoma. Surgery is the treatment of choice. Three forms of surgical interventions are present; curettage, radical resection, and amputation. The choice of procedure depends on the size and site of the lesion and degree of malignancy. Radical procedures give the most promising outcomes with wider margins yielding better prognosis. Recurrence is usually seen with delayed surgery, high histopathologic grading, inadequate surgical procedures, marginal excision or curettage, tumor present in inaccessible sites such as sacrum and metastasis. Conclusion: Chondrosarcoma is responsible for placing a significant burden on pediatric as well as adult orthopedic oncology. Optimum diagnosis, accurate interpretation of histopathology, precise grading, careful localization, and timely as well as adequate management is crucial to successfully manage and prevent recurrence of the disease. Surgery is the most effective form of treatment. The main goal of treatment and management is to keep well ahead of the growth of the neoplasm and to prevent recurrences.
{"title":"Evaluation of different treatment and management options for chondrosarcoma; the prognostic factors determining the outcome of the disease","authors":"K. Abbas, A. Siddiqui","doi":"10.1097/IJ9.0000000000000058","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000058","url":null,"abstract":"Importance: This review provides an in-depth discussion of the different treatment and management strategies adopted for chondrosarcoma, the various outcomes and the prognostic factors of the disease. Chondrosarcoma is the third most common malignant bone tumor after myeloma and osteosarcoma. It is characterized by the production of a cartilaginous matrix by malignant cells. It can be classified according to the source of its origin, histopathologic grade, site of occurrence, and rarity. Chondrosarcomas that are de novo in nature are classified as primary chondrosarcomas, while those derived from pre-existing enchondromas or osteochondromas are regarded as secondary chondrosarcomas. Other rare forms of chondrosarcoma include dedifferentiated, mesenchymal, and clear cell chondrosarcomas. Observations/Findings: Early diagnosis, accurate interpretation of histopathology, precise grading, and careful localization are crucial in the management of chondrosarcoma. Surgery is the treatment of choice. Three forms of surgical interventions are present; curettage, radical resection, and amputation. The choice of procedure depends on the size and site of the lesion and degree of malignancy. Radical procedures give the most promising outcomes with wider margins yielding better prognosis. Recurrence is usually seen with delayed surgery, high histopathologic grading, inadequate surgical procedures, marginal excision or curettage, tumor present in inaccessible sites such as sacrum and metastasis. Conclusion: Chondrosarcoma is responsible for placing a significant burden on pediatric as well as adult orthopedic oncology. Optimum diagnosis, accurate interpretation of histopathology, precise grading, careful localization, and timely as well as adequate management is crucial to successfully manage and prevent recurrence of the disease. Surgery is the most effective form of treatment. The main goal of treatment and management is to keep well ahead of the growth of the neoplasm and to prevent recurrences.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"23 1","pages":"e58"},"PeriodicalIF":0.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83981444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-01DOI: 10.1097/IJ9.0000000000000059
B. Refky, Amr F. Elalfy, H. Nabil, D. El-Emam, K. Abdelwahab, E. Malik, A. Soliman
Introduction: Complete tumor resection for epithelial ovarian cancer (EOC) generally incorporates complex surgical maneuvers, especially bowel resection. This study retrospectively analyzed the impact of neoadjuvant chemotherapy (NAC) on complexity of surgical procedures for EOC (represented by bowel resection) and postoperative morbidity. Methods: We retrospectively recruited all patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stages IIIC–IVB EOC who were treated in our center between 2011 and 2016. Patients were divided into those who received primary debulking followed by chemotherapy (group A), and those who received NAC followed by interval debulking (group B). Patient age, tumor stage, grade, dates of commencement and completion of therapy, intraoperative events, completion of surgical resection, and postoperative events were evaluated. Results: Of 92 patients, 42 were assigned to group A and 50 to group B. Their FIGO stages were group A—stages IIIC: 34 (80.9%), IVA: 6 (14.3%), and IVB: 2 (4.8%); and group B—stages IIIC: 45 (90%), IVA: 5 (10%), and IVB: 0 (0%). The 2 groups did not significantly differ in completeness of surgical cytoreduction or rates of bowel resection, intraoperative complications, or postoperative morbidities. Conclusion: NAC did not reduce rates of bowel resection, intraoperative complications, and postoperative morbidity in advanced EOC compared with primary surgical cytoreduction. Future prospective studies will be required to corroborate our results.
{"title":"Neoadjuvant chemotherapy and the complexity of operative procedure in advanced epithelial ovarian cancer: a retrospective analysis","authors":"B. Refky, Amr F. Elalfy, H. Nabil, D. El-Emam, K. Abdelwahab, E. Malik, A. Soliman","doi":"10.1097/IJ9.0000000000000059","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000059","url":null,"abstract":"Introduction: Complete tumor resection for epithelial ovarian cancer (EOC) generally incorporates complex surgical maneuvers, especially bowel resection. This study retrospectively analyzed the impact of neoadjuvant chemotherapy (NAC) on complexity of surgical procedures for EOC (represented by bowel resection) and postoperative morbidity. Methods: We retrospectively recruited all patients with Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stages IIIC–IVB EOC who were treated in our center between 2011 and 2016. Patients were divided into those who received primary debulking followed by chemotherapy (group A), and those who received NAC followed by interval debulking (group B). Patient age, tumor stage, grade, dates of commencement and completion of therapy, intraoperative events, completion of surgical resection, and postoperative events were evaluated. Results: Of 92 patients, 42 were assigned to group A and 50 to group B. Their FIGO stages were group A—stages IIIC: 34 (80.9%), IVA: 6 (14.3%), and IVB: 2 (4.8%); and group B—stages IIIC: 45 (90%), IVA: 5 (10%), and IVB: 0 (0%). The 2 groups did not significantly differ in completeness of surgical cytoreduction or rates of bowel resection, intraoperative complications, or postoperative morbidities. Conclusion: NAC did not reduce rates of bowel resection, intraoperative complications, and postoperative morbidity in advanced EOC compared with primary surgical cytoreduction. Future prospective studies will be required to corroborate our results.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"38 1","pages":"e59"},"PeriodicalIF":0.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76121006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-01DOI: 10.1097/IJ9.0000000000000053
T. Hassan, F. Parray, Zubaida Rasool, N. Chowdri, F. Shaheen, R. Wani
Introduction: High quality of total mesorectal excision (TME) surgical technique and critical feedback regarding its completeness by pathologist and a radiologist has been shown to influence the quality of surgery in patients with rectal cancer. In this study, we tried to audit the quality of TME by 2 independent observers, a consultant pathologist and radiologist. TME was performed for all patients with rectal tumors located <12 cm from the anal verge. Main Outcome Measures: TME specimens were examined for completeness by experienced single consultant pathologist to avoid interobserver bias. Postoperatively magnetic resonance imaging was done that was interpreted by a single consultant radiologist to avoid interobserver bias in the study. Discussion: Of total 103 patients, TME assessment was done in 53 patients. TME was complete in 35 cases (66%), near complete in 14 cases (26%), and incomplete in 4 cases (8%) (P<0.05). Twenty-eight cases were subjected to radiologic assessment of TME. Complete TME was found in 19 (67%) and residual mesorectum was found in 9 (32%). The radiologic findings co-related with pathology findings in these 28 cases as 17 cases were confirmed TME complete by both magnetic resonance imaging and histopathology, 4 cases were confirmed incomplete by both and out of 7 near complete TME by pathology, 2 were labeled as complete on radiology while 5 were labeled as incomplete (P<0.05). Seven (13.2%) cases had positive circumferential resection margin. Distal resection margin was >2 cm in about 81.1%, <2 cm in 15% and involved in 3.7% of cases. The lymph node yield was of 4–21 with an average of 11.5 nodes; with 54.7% having adequate nodal harvest (>12 lymph nodes). Conclusions: Pathologist’s and radiologist’s constructive criticism will always help a surgeon to improve his quality of TME.
{"title":"Assessment of extent and completeness of mesorectal excision for rectal cancer by histopathology and MRI","authors":"T. Hassan, F. Parray, Zubaida Rasool, N. Chowdri, F. Shaheen, R. Wani","doi":"10.1097/IJ9.0000000000000053","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000053","url":null,"abstract":"Introduction: High quality of total mesorectal excision (TME) surgical technique and critical feedback regarding its completeness by pathologist and a radiologist has been shown to influence the quality of surgery in patients with rectal cancer. In this study, we tried to audit the quality of TME by 2 independent observers, a consultant pathologist and radiologist. TME was performed for all patients with rectal tumors located <12 cm from the anal verge. Main Outcome Measures: TME specimens were examined for completeness by experienced single consultant pathologist to avoid interobserver bias. Postoperatively magnetic resonance imaging was done that was interpreted by a single consultant radiologist to avoid interobserver bias in the study. Discussion: Of total 103 patients, TME assessment was done in 53 patients. TME was complete in 35 cases (66%), near complete in 14 cases (26%), and incomplete in 4 cases (8%) (P<0.05). Twenty-eight cases were subjected to radiologic assessment of TME. Complete TME was found in 19 (67%) and residual mesorectum was found in 9 (32%). The radiologic findings co-related with pathology findings in these 28 cases as 17 cases were confirmed TME complete by both magnetic resonance imaging and histopathology, 4 cases were confirmed incomplete by both and out of 7 near complete TME by pathology, 2 were labeled as complete on radiology while 5 were labeled as incomplete (P<0.05). Seven (13.2%) cases had positive circumferential resection margin. Distal resection margin was >2 cm in about 81.1%, <2 cm in 15% and involved in 3.7% of cases. The lymph node yield was of 4–21 with an average of 11.5 nodes; with 54.7% having adequate nodal harvest (>12 lymph nodes). Conclusions: Pathologist’s and radiologist’s constructive criticism will always help a surgeon to improve his quality of TME.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"6 1","pages":"e53"},"PeriodicalIF":0.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77013911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.1097/IJ9.0000000000000055
A. Fowler, K. Koshy, B. Gundogan, R. Agha
Peer review is a key part of the scientific process, whereby a body of experts review a manuscript and provide feedback. In this article, we discuss the steps typically undertaken in completing a peer review and key questions to be asked of the manuscript while undertaking a review. This article provides a step-by-step instructional guide in how to effectively peer review a paper.
{"title":"Peer review in scholarly publishing part B: how to do it?","authors":"A. Fowler, K. Koshy, B. Gundogan, R. Agha","doi":"10.1097/IJ9.0000000000000055","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000055","url":null,"abstract":"Peer review is a key part of the scientific process, whereby a body of experts review a manuscript and provide feedback. In this article, we discuss the steps typically undertaken in completing a peer review and key questions to be asked of the manuscript while undertaking a review. This article provides a step-by-step instructional guide in how to effectively peer review a paper.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"44 1","pages":"e55"},"PeriodicalIF":0.3,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73294175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.1097/IJ9.0000000000000047
E. Weledji, Divine Eyongetah, T. Nana, M. Ngowe
Background: Pancreatic cysts are frequently detected incidentally, and a definitive preoperative diagnosis remains challenging. Benign cystic lesions have a very high cure rate unless malignant change supervenes. Simple excision of benign cysts of the pancreas is safe and effective. Case presentation: We present a 31-year-old woman with a 3-year history of an enlarging symptomatic benign pancreatic mucinous cystadenoma, which was misdiagnosed radiologically as a pancreatic serous cystadenoma or a mesenteric cyst. This was managed safely by excision and resection with a distal pancreatectomy that was avoided. Conclusions: Excision of benign mucinous cystadenoma of the pancreas is safe and effective, and surveillance for recurrence is not necessary.
{"title":"Excision of mucinous cystadenoma of pancreas is safe and effective: a case report","authors":"E. Weledji, Divine Eyongetah, T. Nana, M. Ngowe","doi":"10.1097/IJ9.0000000000000047","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000047","url":null,"abstract":"Background: Pancreatic cysts are frequently detected incidentally, and a definitive preoperative diagnosis remains challenging. Benign cystic lesions have a very high cure rate unless malignant change supervenes. Simple excision of benign cysts of the pancreas is safe and effective. Case presentation: We present a 31-year-old woman with a 3-year history of an enlarging symptomatic benign pancreatic mucinous cystadenoma, which was misdiagnosed radiologically as a pancreatic serous cystadenoma or a mesenteric cyst. This was managed safely by excision and resection with a distal pancreatectomy that was avoided. Conclusions: Excision of benign mucinous cystadenoma of the pancreas is safe and effective, and surveillance for recurrence is not necessary.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"23 1","pages":"e47"},"PeriodicalIF":0.3,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73194617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.1097/IJ9.0000000000000056
K. Koshy, A. Fowler, B. Gundogan, R. Agha
Peer review is a process whereby scientific experts evaluate a manuscript and provide feedback, offering a recommendation of whether the work is suitable for publication. In this article, we discuss the principles behind peer review and the different forms that it can take. We discuss the importance of peer reviewing, its drawbacks and the reasons an individual may want to become a peer reviewer.
{"title":"Peer review in scholarly publishing part A: why do it?","authors":"K. Koshy, A. Fowler, B. Gundogan, R. Agha","doi":"10.1097/IJ9.0000000000000056","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000056","url":null,"abstract":"Peer review is a process whereby scientific experts evaluate a manuscript and provide feedback, offering a recommendation of whether the work is suitable for publication. In this article, we discuss the principles behind peer review and the different forms that it can take. We discuss the importance of peer reviewing, its drawbacks and the reasons an individual may want to become a peer reviewer.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"45 1","pages":"e56"},"PeriodicalIF":0.3,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73790122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-01DOI: 10.1097/IJ9.0000000000000052
J. Aguilera-Sáez, P. Bosacoma Roura, Anselmo Garrido Ferrer, A. Guinot Madridejos, J. Barret
Introduction: We present our experience in implant-based immediate breast reconstruction (IBIBR) with biological acellular matrix during our learning curve and compare the complications with the use of three different matrices. Materials and methods: We did a retrospective study on patients who underwent an IBIBR with acellular matrix after skin sparing mastectomy with or without nipple-areolar complex preservation at the Breast Pathology Unit at University Hospital Vall d’Hebron, Barcelona (Spain) between July 2011 and December 2014. Results: A total of 84 breasts were reconstructed in 71 women. A therapeutic mastectomy was performed in 55 of them (65.5%) and a prophylactic mastectomy in 29 (34.5%). The total rate of complications was 41.67% (35 patients): we found 11 cases of erythema (13.1%), 19 cases of seroma (22.62%), 9 cases of hematoma (10.71%), 17 cases of wound dehiscence (20.24%), 11 cases of skin flap necrosis (13.1%), and 10 cases of reconstruction failure (11.9%). The probability of reconstruction failure was higher in smokers and former smokers (P=0.0011%). There were more complications with the Protexa matrix than with the other 2, Strattice and Tutomesh (P<0.001) and a higher risk of reconstruction failure as well (P=0.03). Conclusions: In our experience the use of acellular matrix in IBIBR can have a high rate of complications, especially during the learning curve. Therefore, the selection of suitable patients and the better matrix is an issue of great importance to achieve favorable results.
简介:在我们的学习曲线中，我们介绍了使用生物脱细胞基质进行植入式即刻乳房重建(IBIBR)的经验，并比较了使用三种不同基质的并发症。材料和方法:我们对2011年7月至2014年12月在西班牙巴塞罗那Vall d 'Hebron大学医院乳腺病理科进行的保留皮肤乳房切除术(有或没有保留乳头-乳晕复体)后行脱细胞基质IBIBR的患者进行了回顾性研究。结果:71例患者共行84个乳房再造术。其中治疗性乳房切除术55例(65.5%)，预防性乳房切除术29例(34.5%)。并发症发生率为41.67%(35例)，其中红斑11例(13.1%)，血肿19例(22.62%)，血肿9例(10.71%)，创面裂开17例(20.24%)，皮瓣坏死11例(13.1%)，重建失败10例(11.9%)。吸烟者和已戒烟者重建失败的概率较高(P=0.0011%)。与Strattice和Tutomesh相比，Protexa基质的并发症更多(P<0.001)，重建失败的风险也更高(P=0.03)。结论:根据我们的经验，在IBIBR中使用脱细胞基质可能有很高的并发症发生率，特别是在学习曲线期间。因此，选择合适的患者和更好的基质是一个非常重要的问题，以取得良好的效果。
{"title":"Early complications in cases series in implant-based immediate breast reconstruction with a biological acellular matrix during the learning curve of this technique and using 3 different matrices: a case series of 84 breasts","authors":"J. Aguilera-Sáez, P. Bosacoma Roura, Anselmo Garrido Ferrer, A. Guinot Madridejos, J. Barret","doi":"10.1097/IJ9.0000000000000052","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000052","url":null,"abstract":"Introduction: We present our experience in implant-based immediate breast reconstruction (IBIBR) with biological acellular matrix during our learning curve and compare the complications with the use of three different matrices. Materials and methods: We did a retrospective study on patients who underwent an IBIBR with acellular matrix after skin sparing mastectomy with or without nipple-areolar complex preservation at the Breast Pathology Unit at University Hospital Vall d’Hebron, Barcelona (Spain) between July 2011 and December 2014. Results: A total of 84 breasts were reconstructed in 71 women. A therapeutic mastectomy was performed in 55 of them (65.5%) and a prophylactic mastectomy in 29 (34.5%). The total rate of complications was 41.67% (35 patients): we found 11 cases of erythema (13.1%), 19 cases of seroma (22.62%), 9 cases of hematoma (10.71%), 17 cases of wound dehiscence (20.24%), 11 cases of skin flap necrosis (13.1%), and 10 cases of reconstruction failure (11.9%). The probability of reconstruction failure was higher in smokers and former smokers (P=0.0011%). There were more complications with the Protexa matrix than with the other 2, Strattice and Tutomesh (P<0.001) and a higher risk of reconstruction failure as well (P=0.03). Conclusions: In our experience the use of acellular matrix in IBIBR can have a high rate of complications, especially during the learning curve. Therefore, the selection of suitable patients and the better matrix is an issue of great importance to achieve favorable results.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"1 1","pages":"e52"},"PeriodicalIF":0.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89330908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-01Epub Date: 2017-11-16DOI: 10.1097/IJ9.0000000000000049
Mengqi Liu, Wenzhi Guo, Shuijun Zhang
Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer. Organ transplantation can be a life-saving procedure for patients with end-stage diseases of lung, heart, kidney and liver. While ironically, as improvements in organ transplantation have extended patients' lives, new or recurrent postsurgical malignancies have become an increasing threat to their long-term survival, especially in patients after liver transplantation due to hepatocellular carcinoma. The feasibility of immunotherapy treatment for such patients is still to be investigated.
{"title":"Cancer immunotherapy in patients with new or recurrent malignancies after liver transplantation.","authors":"Mengqi Liu, Wenzhi Guo, Shuijun Zhang","doi":"10.1097/IJ9.0000000000000049","DOIUrl":"https://doi.org/10.1097/IJ9.0000000000000049","url":null,"abstract":"<p><p>Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer. Organ transplantation can be a life-saving procedure for patients with end-stage diseases of lung, heart, kidney and liver. While ironically, as improvements in organ transplantation have extended patients' lives, new or recurrent postsurgical malignancies have become an increasing threat to their long-term survival, especially in patients after liver transplantation due to hepatocellular carcinoma. The feasibility of immunotherapy treatment for such patients is still to be investigated.</p>","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"2 11","pages":"e49"},"PeriodicalIF":0.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/IJ9.0000000000000049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35710559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-01DOI: 10.1097/IJ9.0000000000000048
S. S. Agrawal, N. Kaushik
Hepatocellular carcinoma (HCC) is the sixth highest incidence of cancer worldwide, accounting for 5.7% of the overall incident cases of cancer with the third leading cause of cancer-related deaths in all age group population. Matrix metalloproteinases play an important role in cancer progression, including tumor growth, invasion, metastasis, and angiogenesis, thus the drug delivery system targeting on MMP’s would be of good significance. This study aims evaluation of the antimetastatic and antitumor activity, of antibody loaded pemetrexed nanoparticles, in di-ethylnitrosamine-HepG2 hepatocarcinoma model. An orthotopic HCC model was prepared by using di-ethylnitrosamine-CCl4 as a precursor for liver cirrhosis and as carcinogen. Study concludes that the HCC model prepared was fast and equivalent to the other models present. The targeted nanoparticles prepared, has better efficacy profile with lower side effects then the free pemetrexed available in market. Low dose and high dose (20/25 mg)/kg of pemetrexed treats HCC significantly. Our results provide a basis for further study of targeted nanoparticles.
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