R. Guanà, A. Carpino, Carmen Campilongo, L. Lonati, Elena Madonia, S. Garofalo, G. Perucca, Steffi Shilly, F. Gennari
{"title":"A Grasp-Like Vaginal Lesion in a 15-Months-Old Child: A Case Report","authors":"R. Guanà, A. Carpino, Carmen Campilongo, L. Lonati, Elena Madonia, S. Garofalo, G. Perucca, Steffi Shilly, F. Gennari","doi":"10.29337/ijsonco.139","DOIUrl":"https://doi.org/10.29337/ijsonco.139","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90169144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoqi Wang, Peilin Zhang, Kran Suknuntha, Kwok-Kei Lee, E. Shostak, Vijay Jaswani, Jen-Chin Wang
{"title":"IgG4 Related Disease Presenting as Simultaneous Pancreatic and Lung Mass Mimicking Malignancy","authors":"Xiaoqi Wang, Peilin Zhang, Kran Suknuntha, Kwok-Kei Lee, E. Shostak, Vijay Jaswani, Jen-Chin Wang","doi":"10.29337/ijsonco.137","DOIUrl":"https://doi.org/10.29337/ijsonco.137","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77564090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Zaldarriaga, Ma. Elsie M. Dimaano, Katrina Marie G. Santi
{"title":"Stereotactic Body Radiation Therapy (SBRT) Re-irradiation to an Isolated Oligo-Recurrent Lymph Node with Direct Positron Emission Tomography/Computed Tomography Planning: A Case Report","authors":"J. Zaldarriaga, Ma. Elsie M. Dimaano, Katrina Marie G. Santi","doi":"10.29337/ijsonco.144","DOIUrl":"https://doi.org/10.29337/ijsonco.144","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Complete Response of Advanced Lung Squamous Cell Carcinoma in an Elderly Patient Treated with First-Line Anti-PD-1 Antibody Monotherapy: A Case Report","authors":"Xue Pan, Y. Xing, Wen-yan Yang, M. Shi","doi":"10.29337/ijsonco.133","DOIUrl":"https://doi.org/10.29337/ijsonco.133","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80584812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meng Gao, Yonghua Guo, Jinghua Li, Xi Chen, Yufeng Yuan, Weijie Ma
{"title":"The Clinicopathological Significance and Prognostic Value of PD-L2 in Patients with HCC, ICC and PAAD: A Meta-Analysis","authors":"Meng Gao, Yonghua Guo, Jinghua Li, Xi Chen, Yufeng Yuan, Weijie Ma","doi":"10.29337/ijsonco.142","DOIUrl":"https://doi.org/10.29337/ijsonco.142","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74761713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Sarcomas are tumors that are mesenchymal in origin involving bone and soft tissues occurring in all age groups. Giant cell tumor, although benign, is locally aggressive and can also destroy the bone. Amputation was once considered primary treatment but now with advancements in diagnostic imaging modalities, surgical procedures and adjuvant therapies, limb salvage surgeries have become the preferred treatment modality. The primary objective of our study was to determine the incidence of early complications occurring within the first thirty days in patients who underwent limb salvage surgery at our hospital. The secondary objective was to assess the association of these complications with patient-related factors, surgical modality, tumor characteristics and neoadjuvant therapy. Methodology: All the patients with bone or soft tissue sarcoma and aggressive giant cell tumors of the extremities who underwent wide excision and limb salvage surgery from February 2020 to December 2021 were included in this study. Data were collected prospectively on follow-up visits in the clinic for one month. Data were compiled and analyzed using SPSS version 22. A p-value of <0.05 was considered significant throughout the study. Results: A total of 60 patients were included in this study. The mean age of the patients was 39.90 years. Bone and soft tissue tumors were found in 35 and 25 patients respectively. A total of 13 patients experienced postoperative is
{"title":"Early Complications after Limb Salvage Procedures: Prospective Cross Sectional Study","authors":"Z. Ali, Javeria Saeed, M. Umer","doi":"10.29337/ijsonco.143","DOIUrl":"https://doi.org/10.29337/ijsonco.143","url":null,"abstract":"Introduction: Sarcomas are tumors that are mesenchymal in origin involving bone and soft tissues occurring in all age groups. Giant cell tumor, although benign, is locally aggressive and can also destroy the bone. Amputation was once considered primary treatment but now with advancements in diagnostic imaging modalities, surgical procedures and adjuvant therapies, limb salvage surgeries have become the preferred treatment modality. The primary objective of our study was to determine the incidence of early complications occurring within the first thirty days in patients who underwent limb salvage surgery at our hospital. The secondary objective was to assess the association of these complications with patient-related factors, surgical modality, tumor characteristics and neoadjuvant therapy. Methodology: All the patients with bone or soft tissue sarcoma and aggressive giant cell tumors of the extremities who underwent wide excision and limb salvage surgery from February 2020 to December 2021 were included in this study. Data were collected prospectively on follow-up visits in the clinic for one month. Data were compiled and analyzed using SPSS version 22. A p-value of <0.05 was considered significant throughout the study. Results: A total of 60 patients were included in this study. The mean age of the patients was 39.90 years. Bone and soft tissue tumors were found in 35 and 25 patients respectively. A total of 13 patients experienced postoperative is","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90602298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Arrest Due to Severe Vasovagal Response After Spinal Anaesthesia in Caesarean Section: Case Report","authors":"Z. Bekele, F. Abebe","doi":"10.29337/ijsonco.134","DOIUrl":"https://doi.org/10.29337/ijsonco.134","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72478955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaomeng Wang, Na Pan, J M Cao, Weijiao Du, Weihong Zhang, S. Cao
{"title":"An Analysis of Clinical and Pathological Characteristics of 14431 Cases of Thyroid Carcinoma","authors":"Xiaomeng Wang, Na Pan, J M Cao, Weijiao Du, Weihong Zhang, S. Cao","doi":"10.29337/ijsonco.145","DOIUrl":"https://doi.org/10.29337/ijsonco.145","url":null,"abstract":"","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85031875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Zhang, H. Bi, Ye Yan, Zhuo Liu, Guo-liang Wang, Yimeng Song, J. Dong, Shudong Zhang, Cheng Liu, Lulin Ma
Background: To compare the surgical and oncologic outcomes between laparoscopic and open radical nephrectomy with venous thrombectomy (LRN-VT, ORN-VT) in patients with renal tumor and venous thrombus. Materials and Methods: We conducted a propensity-matched retrospective cohort study of 302 patients with renal tumor and venous thrombus from January 2014 to January 2021. We compared surgical outcomes and we used the Kalan-Meier method to assess the overall survival (OS), tumor-specific survival (TSS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS). The Pearson chi-square test and Fisher exact test, Wilcoxon rank sum test, Cox proportional hazards regression model and log-rank test were used. Results: After 1:1 matching, 94 patients were identified in each group and baseline characteristics were comparable. The LRN-VT group had less operative time (median 292min vs 326min, P < 0.001), less blood loss (median 500 ml vs 1000 ml, P < 0.001), fewer packed red blood cells transfusion (median 800 ml vs 1200 ml, P < 0.001) and less fresh frozen plasma transfusion (median 400 ml vs 600 ml, P < 0.001). The ORN-VT group had higher complication rate (39.4% vs 21.3%, P = 0.007), higher Clavien grade (P = 0.005) and longer postoperative hospital stay (median 10d vs 8d, P < 0.001). The median time to local recurrence were 36mon after a median follow-up of 31mon in the LRN-VT group and 8mon (IQR 6-15 mon) after a median follow-up of 32mon in the ORN-VT group (P = 0.007). The hazard ratio of LRFS for the LRN-VT group was 0.18 (95% CI 0.05–0.62, P = 0.007). Conclusions: LRN-VT can result in favorable surgical outcomes and a better LRFS compared with ORN-VT. CORRESPONDING AUTHORS: Cheng Liu and LuLin Ma Department of Urology, Peking University Third Hospital, Beijing, People’s Republic of China, 49 North Garden Rd, Haidian District, Beijing 100191, China chengliu@bjmu.edu.cn; malulinpku@163.com
背景:比较腹腔镜和开放式根治性肾切除术合并静脉血栓切除术(LRN-VT, ORN-VT)对肾肿瘤和静脉血栓患者的手术和肿瘤预后。材料与方法:2014年1月至2021年1月，我们对302例肾肿瘤和静脉血栓患者进行了倾向匹配的回顾性队列研究。我们比较了手术结果，并使用Kalan-Meier法评估总生存期(OS)、肿瘤特异性生存期(TSS)、无转移生存期(MFS)和局部无复发生存期(LRFS)。采用Pearson卡方检验、Fisher精确检验、Wilcoxon秩和检验、Cox比例风险回归模型和log-rank检验。结果:经1:1匹配后，每组确定94例患者，基线特征具有可比性。LRN-VT组手术时间更短(中位292min vs 326min, P < 0.001)，出血量更少(中位500 ml vs 1000 ml, P < 0.001)，填充红细胞输注更少(中位800 ml vs 1200 ml, P < 0.001)，新鲜冷冻血浆输注更少(中位400 ml vs 600 ml, P < 0.001)。ORN-VT组并发症发生率较高(39.4% vs 21.3%， P = 0.007)， Clavien分级较高(P = 0.005)，术后住院时间较长(中位10d vs 8d, P < 0.001)。LRN-VT组中位随访31个月后的中位局部复发时间为36个月，ORN-VT组中位随访32个月后的中位局部复发时间为8个月(IQR 6 ~ 15个月)(P = 0.007)。LRN-VT组LRFS的风险比为0.18 (95% CI 0.05 ~ 0.62, P = 0.007)。结论:与ORN-VT相比，LRN-VT可获得良好的手术效果和更好的LRFS。通讯作者:刘成、马鲁林中华人民共和国北京大学第三医院泌尿外科，北京市海淀区北花园路49号，中国北京，100191 chengliu@bjmu.edu.cn;malulinpku@163.com
{"title":"Surgical and Oncologic Outcomes of Laparoscopic Versus Open Radical Nephrectomy with Venous Thrombectomy: A Propensity-Matched Retrospective Cohort Study","authors":"Yu Zhang, H. Bi, Ye Yan, Zhuo Liu, Guo-liang Wang, Yimeng Song, J. Dong, Shudong Zhang, Cheng Liu, Lulin Ma","doi":"10.29337/ijsonco.127","DOIUrl":"https://doi.org/10.29337/ijsonco.127","url":null,"abstract":"Background: To compare the surgical and oncologic outcomes between laparoscopic and open radical nephrectomy with venous thrombectomy (LRN-VT, ORN-VT) in patients with renal tumor and venous thrombus. Materials and Methods: We conducted a propensity-matched retrospective cohort study of 302 patients with renal tumor and venous thrombus from January 2014 to January 2021. We compared surgical outcomes and we used the Kalan-Meier method to assess the overall survival (OS), tumor-specific survival (TSS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS). The Pearson chi-square test and Fisher exact test, Wilcoxon rank sum test, Cox proportional hazards regression model and log-rank test were used. Results: After 1:1 matching, 94 patients were identified in each group and baseline characteristics were comparable. The LRN-VT group had less operative time (median 292min vs 326min, P < 0.001), less blood loss (median 500 ml vs 1000 ml, P < 0.001), fewer packed red blood cells transfusion (median 800 ml vs 1200 ml, P < 0.001) and less fresh frozen plasma transfusion (median 400 ml vs 600 ml, P < 0.001). The ORN-VT group had higher complication rate (39.4% vs 21.3%, P = 0.007), higher Clavien grade (P = 0.005) and longer postoperative hospital stay (median 10d vs 8d, P < 0.001). The median time to local recurrence were 36mon after a median follow-up of 31mon in the LRN-VT group and 8mon (IQR 6-15 mon) after a median follow-up of 32mon in the ORN-VT group (P = 0.007). The hazard ratio of LRFS for the LRN-VT group was 0.18 (95% CI 0.05–0.62, P = 0.007). Conclusions: LRN-VT can result in favorable surgical outcomes and a better LRFS compared with ORN-VT. CORRESPONDING AUTHORS: Cheng Liu and LuLin Ma Department of Urology, Peking University Third Hospital, Beijing, People’s Republic of China, 49 North Garden Rd, Haidian District, Beijing 100191, China chengliu@bjmu.edu.cn; malulinpku@163.com","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80714644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Szeto, Muhammad Krenawi, G. Ben-Arie, Benzion Samueli, O. Lavon, Shadi Abu-Swis, M. Zemel, D. Levitas, W. Kian, E. Mazor
Introduction and importance: Collision tumors refer to the phenomenon where two or more different and unrelated tumors occur in the same location of an organ and form a single lesion. We present the first case of renal collision tumors composed of clear cell carcinoma (ccRCC) and collecting duct carcinoma (CDC) treated with combined therapy of nivolumab and ipilimumab. Case presentation: An 89-year-old male presented to the emergency room with back pain. Imaging studies demonstrated a large tumor in the left kidney with renal vein thrombosis. After radical nephrectomy, the histopathological report showed collision tumors with ccRCC and CDC components. The patient was included in a treatment protocol based on nivolumab (220 mg) and ipilimumab (73 mg) every 21 days, however, obtaining no clinical responses after 5 cycles of treatments. Clinical Discussion: Immune checkpoint inhibitors have become a new standard of care for patients with advanced ccRCC. However, current literatures showed inconclusive evidence on the efficacy of immune checkpoint inhibitor for metastatic CDC. As collision tumors with ccRCC and CDC components were infrequently reported in the literature, we also discuss the histological and immunohistochemical findings, clinical outcomes, and a literature review on this type of renal collision tumors. Conclusion: CDC is a rare and highly aggressive type of renal neoplasms, with limited treatment choices. More studies are needed to evaluate the efficacy of immune checkpoint inhibitors on CDC and its associated collision tumors. Highlights: Collecting duct carcinoma is a rare and highly aggressive type of renal neoplasms, with a poor clinical outcome. Radical nephrectomy alone is rarely curative. The use of immune checkpoint inhibitors for collecting duct carcinoma needs further evaluation. The use of HMWCK as a histologic marker for differential diagnosis of collecting duct carcinoma may need to be evaluated.
{"title":"Renal Collision Tumor Composed of Clear Cell Carcinoma and Collecting Duct Carcinoma Treated with Nivolumab and Ipilimumab: Case Report and Literature Review","authors":"C. Szeto, Muhammad Krenawi, G. Ben-Arie, Benzion Samueli, O. Lavon, Shadi Abu-Swis, M. Zemel, D. Levitas, W. Kian, E. Mazor","doi":"10.29337/ijsonco.128","DOIUrl":"https://doi.org/10.29337/ijsonco.128","url":null,"abstract":"Introduction and importance: Collision tumors refer to the phenomenon where two or more different and unrelated tumors occur in the same location of an organ and form a single lesion. We present the first case of renal collision tumors composed of clear cell carcinoma (ccRCC) and collecting duct carcinoma (CDC) treated with combined therapy of nivolumab and ipilimumab. Case presentation: An 89-year-old male presented to the emergency room with back pain. Imaging studies demonstrated a large tumor in the left kidney with renal vein thrombosis. After radical nephrectomy, the histopathological report showed collision tumors with ccRCC and CDC components. The patient was included in a treatment protocol based on nivolumab (220 mg) and ipilimumab (73 mg) every 21 days, however, obtaining no clinical responses after 5 cycles of treatments. Clinical Discussion: Immune checkpoint inhibitors have become a new standard of care for patients with advanced ccRCC. However, current literatures showed inconclusive evidence on the efficacy of immune checkpoint inhibitor for metastatic CDC. As collision tumors with ccRCC and CDC components were infrequently reported in the literature, we also discuss the histological and immunohistochemical findings, clinical outcomes, and a literature review on this type of renal collision tumors. Conclusion: CDC is a rare and highly aggressive type of renal neoplasms, with limited treatment choices. More studies are needed to evaluate the efficacy of immune checkpoint inhibitors on CDC and its associated collision tumors. Highlights: Collecting duct carcinoma is a rare and highly aggressive type of renal neoplasms, with a poor clinical outcome. Radical nephrectomy alone is rarely curative. The use of immune checkpoint inhibitors for collecting duct carcinoma needs further evaluation. The use of HMWCK as a histologic marker for differential diagnosis of collecting duct carcinoma may need to be evaluated.","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85282495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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