Objective: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous syndrome. The most crucial morbidity of NF1 is tumors that may develop. Cases with café-au-lait macules (CALMs) which is the first clinical finding of NF1, due to the anxiety of its associated morbidity, are referred to the pediatric oncology clinic. In this study, we aimed to examine the characteristics of the patients who applied to our outpatient clinic with CALMs. Patients and Methods: The data of 157 pediatric patients who applied to our institution with the diagnosis of CALMs between June 2010 and November 2020 were analyzed retrospectively. Results: There were 157 pediatric cases referred to us for CALMs. According to the National Institutes of Health (NIH) diagnostic criteria, 109 (69.4%) cases were diagnosed with NF1. The diagnosis of 22 cases with NF1 were supported by genetic examination. Optic glioma was detected in 39 (24.8%) cases. In 15 (38.4%) of cases with optic glioma, visual functions were also affected. Second diagnostic criterion did not develop during the follow-up period, except for macules, in 48 cases (30.5%). Conclusion: In cases with multiple CALMs, the probability of NF1 diagnosis is high, and close and regular follow-up is of great importance in catching the development of the second clinical criterion and minimizing its morbidity.
{"title":"Is neurofibromatosis type 1 diagnosed in every patient who presents with café au lait macules? A single-center experience","authors":"N. Eker, A. Tokuç, Burcu TAS TUFAN, E. Şenay","doi":"10.5472/marumj.1302264","DOIUrl":"https://doi.org/10.5472/marumj.1302264","url":null,"abstract":"Objective: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous syndrome. The most crucial morbidity of \u0000NF1 is tumors that may develop. Cases with café-au-lait macules (CALMs) which is the first clinical finding of NF1, due to the anxiety \u0000of its associated morbidity, are referred to the pediatric oncology clinic. In this study, we aimed to examine the characteristics of the \u0000patients who applied to our outpatient clinic with CALMs. \u0000Patients and Methods: The data of 157 pediatric patients who applied to our institution with the diagnosis of CALMs between June \u00002010 and November 2020 were analyzed retrospectively. \u0000Results: There were 157 pediatric cases referred to us for CALMs. According to the National Institutes of Health (NIH) diagnostic \u0000criteria, 109 (69.4%) cases were diagnosed with NF1. The diagnosis of 22 cases with NF1 were supported by genetic examination. \u0000Optic glioma was detected in 39 (24.8%) cases. In 15 (38.4%) of cases with optic glioma, visual functions were also affected. Second \u0000diagnostic criterion did not develop during the follow-up period, except for macules, in 48 cases (30.5%). \u0000Conclusion: In cases with multiple CALMs, the probability of NF1 diagnosis is high, and close and regular follow-up is of great \u0000importance in catching the development of the second clinical criterion and minimizing its morbidity.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43018331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The present study is to document and provide information about both normal and variable morphology of the deep palmar arch (DPA) in adult human cadavers by the dissection method. Materials and Methods: We examined 12 upper extremities (6 cadavers). After the classification of the vascular patterns of DPA and its branches, measurements of the vessel diameters were carried out using a digital compass. Results: Deep palmar arch was found as a completed arch (100%) in all cases. The anastomosis between the distal deep palmar branch of the ulnar artery (DPBUA) and the terminal branch of the radial artery (RA) was the most common type in our study. The incidence of the DPA was reported as a complete arch ranging from 54.9% to 100%. Palmar metacarpal arteries (MPAs) originating from the DPA were divided into four branches (25%) in three cases and three branches (75%) in nine cases. The mean diameter of the MPAs at the point of origin at the DPA was between 0.3 mm and 0.6 mm. Conclusion: A comprehensive understanding of the DPA branching diameters in the hand will facilitate surgical and radiological approaches and contribute to a constantly expanding knowledge base in literature.
{"title":"Formation and branching patterns of deep palmar arch","authors":"R. Hamutoğlu, Ş. Peştemalci, M. Yildirim","doi":"10.5472/marumj.1302406","DOIUrl":"https://doi.org/10.5472/marumj.1302406","url":null,"abstract":"Objective: The present study is to document and provide information about both normal and variable morphology of the deep palmar \u0000arch (DPA) in adult human cadavers by the dissection method. \u0000Materials and Methods: We examined 12 upper extremities (6 cadavers). After the classification of the vascular patterns of DPA and \u0000its branches, measurements of the vessel diameters were carried out using a digital compass. \u0000Results: Deep palmar arch was found as a completed arch (100%) in all cases. The anastomosis between the distal deep palmar branch \u0000of the ulnar artery (DPBUA) and the terminal branch of the radial artery (RA) was the most common type in our study. The incidence \u0000of the DPA was reported as a complete arch ranging from 54.9% to 100%. Palmar metacarpal arteries (MPAs) originating from the \u0000DPA were divided into four branches (25%) in three cases and three branches (75%) in nine cases. The mean diameter of the MPAs at \u0000the point of origin at the DPA was between 0.3 mm and 0.6 mm. \u0000Conclusion: A comprehensive understanding of the DPA branching diameters in the hand will facilitate surgical and radiological \u0000approaches and contribute to a constantly expanding knowledge base in literature.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46266608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ben Azir Begum Hymabaccus, R. T. Doğrul, C. Balcı, Cemile Ozsurekci, H. Çalışkan, E. Karabulut, M. Halil, M. Cankurtaran, Burcu Balam Doğu
Objective: Practical scales with tested validity and reliability are needed to clinically determine frailty.The aim of this study is to find out whether the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale is an effective screening scale to show frailty Patients and Methods: The Frail non-Disabled (FIND) scale validated in the Turkish population was applied for FRAIL scale validation. Comprehensive geriatric assessment and Fried Index were performed on 85 outpatients who were 65 years and older. The patients were examined in terms of comorbidity, number of falls, living environment, number of drugs used, and hospitalization in the last year. Results: The FRAIL scale had a high correlation with the FIND scale and Fried Index (correlation coefficients are 0.956 and 0.934, respectively).In addition, it was found to be associated with Activities of Daily Living (ADL),Instrumental Activities of Daily Living (IADL) scales,the Mini-Mental State Examination (MMSE),Yesavage Geriatric Depression Scale (GDS),Mini Nutritional Assessment short-form (MNA-sf),Clock Drawing Test (CDT),handgrip strength, and timed up and go test(p
{"title":"An effective and practical tool to assess physical frailty in older adults: Turkish validation of the FRAIL scale","authors":"Ben Azir Begum Hymabaccus, R. T. Doğrul, C. Balcı, Cemile Ozsurekci, H. Çalışkan, E. Karabulut, M. Halil, M. Cankurtaran, Burcu Balam Doğu","doi":"10.5472/marumj.1297696","DOIUrl":"https://doi.org/10.5472/marumj.1297696","url":null,"abstract":"Objective: Practical scales with tested validity and reliability are needed to clinically determine frailty.The aim of this study is to find \u0000out whether the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale is an effective screening scale to show \u0000frailty \u0000Patients and Methods: The Frail non-Disabled (FIND) scale validated in the Turkish population was applied for FRAIL scale validation. \u0000Comprehensive geriatric assessment and Fried Index were performed on 85 outpatients who were 65 years and older. The patients were \u0000examined in terms of comorbidity, number of falls, living environment, number of drugs used, and hospitalization in the last year. \u0000Results: The FRAIL scale had a high correlation with the FIND scale and Fried Index (correlation coefficients are 0.956 and 0.934, \u0000respectively).In addition, it was found to be associated with Activities of Daily Living (ADL),Instrumental Activities of Daily Living \u0000(IADL) scales,the Mini-Mental State Examination (MMSE),Yesavage Geriatric Depression Scale (GDS),Mini Nutritional Assessment \u0000short-form (MNA-sf),Clock Drawing Test (CDT),handgrip strength, and timed up and go test(p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44630599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Serdar DEMIR, Ayhan KUP, Kamil GULSEN, Abdulkadir USLU, Ayhan TOSUN, Mehmet ÇELİK, Cagan YILDIRIM, Taylan AKGUN, Alper KEPEZ
Objective: Premature ventricular complexes (PVCs) are common arrhythmias and catheter ablation (CA) is the major treatment in
patients with PVCs. In this study, we aimed to share our experience on PVCs patients who had undergone CA.
Patients and Methods: We investigated consecutive patients who had undergone CA because of PVCs between January 2015 and
March 2021 in a single centre arrhythmia unit. Patients’ characteristics, rhythm Holter recordings, echocardiography results and CA
outcomes were noted. Patients were followed up for 22.3±3.7 months. Descriptive statistics were used to demonstrate features of study
patients.
Results: Study population consisted of 645 patients; mean age was 51 ± 4.14 and 372 (57.7%) were male. Arrhythmia originated
from the right ventricular outflow tract in 279 (46.6 %) patients, coronary cusps in 161 (26.9 %) patients, left ventricle summit in 50
(8.3%) patients and inside of the right or left ventricle in remaining patients. Sustained procedural success was achieved in 526 (88.1
%) patients. Recurrence was observed in 46 (6.7%) patients during follow-up. Major complication occurred in two patients (one
procedural mortality due to coronary artery injury and one tamponade).
Conclusion: Premature ventricular contraction ablation can be utilized safely with high success rate. Most PVCs originate from the
right or left ventricular outflow tract.
{"title":"Patients’ characteristics and procedural outcomes of premature ventricular complex ablation: Data of a single-centre arrhythmia unit experience","authors":"Serdar DEMIR, Ayhan KUP, Kamil GULSEN, Abdulkadir USLU, Ayhan TOSUN, Mehmet ÇELİK, Cagan YILDIRIM, Taylan AKGUN, Alper KEPEZ","doi":"10.5472/marumj.1378571","DOIUrl":"https://doi.org/10.5472/marumj.1378571","url":null,"abstract":"Objective: Premature ventricular complexes (PVCs) are common arrhythmias and catheter ablation (CA) is the major treatment in
 patients with PVCs. In this study, we aimed to share our experience on PVCs patients who had undergone CA.
 Patients and Methods: We investigated consecutive patients who had undergone CA because of PVCs between January 2015 and
 March 2021 in a single centre arrhythmia unit. Patients’ characteristics, rhythm Holter recordings, echocardiography results and CA
 outcomes were noted. Patients were followed up for 22.3±3.7 months. Descriptive statistics were used to demonstrate features of study
 patients.
 Results: Study population consisted of 645 patients; mean age was 51 ± 4.14 and 372 (57.7%) were male. Arrhythmia originated
 from the right ventricular outflow tract in 279 (46.6 %) patients, coronary cusps in 161 (26.9 %) patients, left ventricle summit in 50
 (8.3%) patients and inside of the right or left ventricle in remaining patients. Sustained procedural success was achieved in 526 (88.1
 %) patients. Recurrence was observed in 46 (6.7%) patients during follow-up. Major complication occurred in two patients (one
 procedural mortality due to coronary artery injury and one tamponade).
 Conclusion: Premature ventricular contraction ablation can be utilized safely with high success rate. Most PVCs originate from the
 right or left ventricular outflow tract.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134955439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elif TURKOGLU CETIN, Özgül SALİHOĞLU, Melih GÖNEN, Nazan Neslihan DOĞAN
(LP) infants (born between 34 0/7 and 36 6/7 weeks of gestational age) monitored in the neonatal intensive care unit (NICU). Patients and Methods: This retrospective study was conducted by reviewing live-born LP neonates from singleton pregnancies. The infants were monitored and treated in our hospital’s NICU between June 2016 and June 2019. Results: Maternal age at delivery was higher among infants with adequate vitamin D levels than among those with deficient vitamin D levels (P=0.007). A weak positive correlation was found between maternal age at childbirth and neonates’ vitamin D levels (r=0.296). The rate of low-birth-weight deliveries was greater in babies with sufficient vitamin D levels than in those with deficient levels. There was a weak negative association between the number of stools on the day that the infants’ serum 25-hydroxyvitamin D (25-OHD) levels were taken and their vitamin D level (P=0.027, r=-0.244). Conclusions: A significant correlation was shown between serum 25-OHD levels and maternal age and low birth weight in LP neonates. Upon examining the influence of vitamin D levels on the number of defecations per day, no significant difference was detected; however, a weak negative association was identified between them.
{"title":"The association of serum 25-hydroxyvitamin D levels with early neonatal morbidity and mortality in late preterm infants monitored in the neonatal intensive care unit","authors":"Elif TURKOGLU CETIN, Özgül SALİHOĞLU, Melih GÖNEN, Nazan Neslihan DOĞAN","doi":"10.5472/marumj.1380019","DOIUrl":"https://doi.org/10.5472/marumj.1380019","url":null,"abstract":"(LP) infants (born between 34 0/7 and 36 6/7 weeks of gestational age) monitored in the neonatal intensive care unit (NICU). Patients and Methods: This retrospective study was conducted by reviewing live-born LP neonates from singleton pregnancies. The infants were monitored and treated in our hospital’s NICU between June 2016 and June 2019. Results: Maternal age at delivery was higher among infants with adequate vitamin D levels than among those with deficient vitamin D levels (P=0.007). A weak positive correlation was found between maternal age at childbirth and neonates’ vitamin D levels (r=0.296). The rate of low-birth-weight deliveries was greater in babies with sufficient vitamin D levels than in those with deficient levels. There was a weak negative association between the number of stools on the day that the infants’ serum 25-hydroxyvitamin D (25-OHD) levels were taken and their vitamin D level (P=0.027, r=-0.244). Conclusions: A significant correlation was shown between serum 25-OHD levels and maternal age and low birth weight in LP neonates. Upon examining the influence of vitamin D levels on the number of defecations per day, no significant difference was detected; however, a weak negative association was identified between them.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135708197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hazal TAŞ, Ahmet YARDIMCI, Hilmi UYSAL, Uğur BİLGE
Objective: Gait analysis is a method that is used for understanding normal walking and determining the stage of the disease as it affects
walking. It is important to objectively determine the stage of the disease in order to decide interventions and treatment strategies. This
study aims to determine the Brunnstrom Stage of the hemiplegic patients with an analysis of gait data.
Patients and Methods: In the first part of the study, the gait signal data were taken from 28 post-stroke hemiplegic patients and
7 healthy individuals with three-axis accelerometers. In the second part, new gait data were collected from 15 healthy individuals
through an accelerometer on the anteroposterior axis.
First the accelerometer signals were decomposed to Daubechies 5 (Db5) level six wavelets using MATLAB software. Subsequently,
these attributes were classified through several classifier and machine learning algorithms on WEKA and MATLAB software packages
to predict the stages of hemiplegia.
Results: The highest accuracy rate in the prediction of hemiplegia stage was achieved with the LogitBoost algorithm on WEKA with
91% for 35 samples, and 90% for 50 samples. This performance was followed by the RUSBoosted Trees algorithm on the MATLAB
software with an accuracy of 86.1% correct prediction.
Conclusion: The Brunnstrom Stage of hemiplegia can be predicted with machine learning algorithms with a good accuracy, helping
physicians to classify hemiplegic patients into correct stages, monitor and manage their rehabilitation.
{"title":"Classification of hemiplegia through gait analysis and machine learning methods","authors":"Hazal TAŞ, Ahmet YARDIMCI, Hilmi UYSAL, Uğur BİLGE","doi":"10.5472/marumj.1379890","DOIUrl":"https://doi.org/10.5472/marumj.1379890","url":null,"abstract":"Objective: Gait analysis is a method that is used for understanding normal walking and determining the stage of the disease as it affects
 walking. It is important to objectively determine the stage of the disease in order to decide interventions and treatment strategies. This
 study aims to determine the Brunnstrom Stage of the hemiplegic patients with an analysis of gait data.
 Patients and Methods: In the first part of the study, the gait signal data were taken from 28 post-stroke hemiplegic patients and
 7 healthy individuals with three-axis accelerometers. In the second part, new gait data were collected from 15 healthy individuals
 through an accelerometer on the anteroposterior axis.
 First the accelerometer signals were decomposed to Daubechies 5 (Db5) level six wavelets using MATLAB software. Subsequently,
 these attributes were classified through several classifier and machine learning algorithms on WEKA and MATLAB software packages
 to predict the stages of hemiplegia.
 Results: The highest accuracy rate in the prediction of hemiplegia stage was achieved with the LogitBoost algorithm on WEKA with
 91% for 35 samples, and 90% for 50 samples. This performance was followed by the RUSBoosted Trees algorithm on the MATLAB
 software with an accuracy of 86.1% correct prediction.
 Conclusion: The Brunnstrom Stage of hemiplegia can be predicted with machine learning algorithms with a good accuracy, helping
 physicians to classify hemiplegic patients into correct stages, monitor and manage their rehabilitation.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135239454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Crohn’s disease (CD), which can be localized in any part of the gastrointestinal tract, is a disease characterized by an irregular immune response to normal and/or abnormal microbial antigens. Recent studies show many extensive data about the roles of genetic and environmental factors, immune function, and gut microbiota in CD. Although, less invasive biomarkers are currently being developed, the diagnosis of the disease is still based on the endoscopy and histological evaluation of biopsy samples. The most common symptoms are diarrhea, abdominal pain, weight loss, and fatigue. Despite the improvements in the treatment methods in the last decade, there is no definitive treatment since the etiology of CD is not known exactly. Therapeutic strategies focus on reducing inflammation and symptoms, maintaining clinical remission, and improving quality of life.
{"title":"Crohn’s disease: Etiology, pathogenesis and treatment strategies","authors":"I. A. Basoglu, Berna Karakoyun","doi":"10.5472/marumj.1307982","DOIUrl":"https://doi.org/10.5472/marumj.1307982","url":null,"abstract":"Crohn’s disease (CD), which can be localized in any part of the gastrointestinal tract, is a disease characterized by an irregular immune \u0000response to normal and/or abnormal microbial antigens. Recent studies show many extensive data about the roles of genetic and \u0000environmental factors, immune function, and gut microbiota in CD. Although, less invasive biomarkers are currently being developed, \u0000the diagnosis of the disease is still based on the endoscopy and histological evaluation of biopsy samples. The most common symptoms \u0000are diarrhea, abdominal pain, weight loss, and fatigue. Despite the improvements in the treatment methods in the last decade, there \u0000is no definitive treatment since the etiology of CD is not known exactly. Therapeutic strategies focus on reducing inflammation and \u0000symptoms, maintaining clinical remission, and improving quality of life.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43618046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims at examining dietary intake in children and adolescents with type 1 diabetes mellitus (DM) and comparing the results with national dietary intake recommendations. Patients and Methods: One hundred fifty children and adolescents (52.7% female) with an average age of 12.2±3.1 years and with type 1 DM who were followed by the Pediatric Endocrinology Polyclinic participated in the study. Three-day food intake records and clinical information regarding the type 1 DM condition of the participants were obtained. Results: No gender-related significant difference was found among the participants regarding food intake. The percentage of energy derived from fat (average 39.6%) and saturated fat (16.1%) were higher than the recommended levels in both gender groups. The percentage of energy derived from carbohydrates (female 44.1±5.7%, male 43.0±6.8%) was below the recommended levels. The dietary fiber intake in children aged 6-10 years with type 1 DM met recommendations, whereas, it was below the recommended levels in other age groups. Micronutrient inadequacy was common in children and adolescents with type 1 DM. Conclusions: The authors believe that guidelines and programs are needed for children and adolescents with type 1 DM to reduce total fat and saturated fat intake, increase carbohydrate and dietary fiber intake up to the recommended levels, and prevent multiple micronutrient inadequacies.
{"title":"Assessments of energy, macro and micronutrient intakes in children and adolescents with type 1 diabetes mellitus","authors":"Volkan Ozkaya, Sebnem OZGEN OZKAYA","doi":"10.5472/marumj.1307977","DOIUrl":"https://doi.org/10.5472/marumj.1307977","url":null,"abstract":"Objective: This study aims at examining dietary intake in children and adolescents with type 1 diabetes mellitus (DM) and comparing \u0000the results with national dietary intake recommendations. \u0000Patients and Methods: One hundred fifty children and adolescents (52.7% female) with an average age of 12.2±3.1 years and with \u0000type 1 DM who were followed by the Pediatric Endocrinology Polyclinic participated in the study. Three-day food intake records and \u0000clinical information regarding the type 1 DM condition of the participants were obtained. \u0000Results: No gender-related significant difference was found among the participants regarding food intake. The percentage of energy \u0000derived from fat (average 39.6%) and saturated fat (16.1%) were higher than the recommended levels in both gender groups. The \u0000percentage of energy derived from carbohydrates (female 44.1±5.7%, male 43.0±6.8%) was below the recommended levels. The dietary \u0000fiber intake in children aged 6-10 years with type 1 DM met recommendations, whereas, it was below the recommended levels in other \u0000age groups. Micronutrient inadequacy was common in children and adolescents with type 1 DM. \u0000Conclusions: The authors believe that guidelines and programs are needed for children and adolescents with type 1 DM to reduce \u0000total fat and saturated fat intake, increase carbohydrate and dietary fiber intake up to the recommended levels, and prevent multiple \u0000micronutrient inadequacies.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49209332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metabolic syndrome (MetS); is defined as a life-threatening endocrinopathy in which systemic disorders such as insulin resistance, abdominal obesity, glucose intolerance, diabetes mellitus, dyslipidemia, hypertension, and coronary artery disease are combined. Although, it is generally known as a problem of adults, it emerges as an essential problem in childhood and adolescence. MetS, closely related to obesity, is increasing due to bad eating habits and sedentary lifestyles. The pathophysiology of MetS has yet to be elucidated. Therefore, lifestyle changes, especially diet and physical activity, are the cornerstones of MetS treatment. In general, both physical activity and fitness; appear to be separately and independently associated with metabolic risk factors in children and adolescents. Although, studies show that activities that increase physical activity levels and improve aerobic fitness cause a decrease in the risk of MetS; a definitive prescription for exercise has not been established at this time. This review aimed to review the definition, classification, and factors playing a role in the pathogenesis of MetS, as well as to evaluate the relationship between MetS and physical activity and aerobic fitness in children.
{"title":"A growing problem in childhood and adolescence: Metabolic syndrome and its relationship with physical activity and fitness","authors":"Adnan Barutçu, Ceren Ornek, E. Kozanoğlu","doi":"10.5472/marumj.1307990","DOIUrl":"https://doi.org/10.5472/marumj.1307990","url":null,"abstract":"Metabolic syndrome (MetS); is defined as a life-threatening endocrinopathy in which systemic disorders such as insulin resistance, \u0000abdominal obesity, glucose intolerance, diabetes mellitus, dyslipidemia, hypertension, and coronary artery disease are combined. \u0000Although, it is generally known as a problem of adults, it emerges as an essential problem in childhood and adolescence. MetS, \u0000closely related to obesity, is increasing due to bad eating habits and sedentary lifestyles. The pathophysiology of MetS has yet to \u0000be elucidated. Therefore, lifestyle changes, especially diet and physical activity, are the cornerstones of MetS treatment. In general, \u0000both physical activity and fitness; appear to be separately and independently associated with metabolic risk factors in children and \u0000adolescents. Although, studies show that activities that increase physical activity levels and improve aerobic fitness cause a decrease in \u0000the risk of MetS; a definitive prescription for exercise has not been established at this time. This review aimed to review the definition, \u0000classification, and factors playing a role in the pathogenesis of MetS, as well as to evaluate the relationship between MetS and physical \u0000activity and aerobic fitness in children.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47704058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In the literature, plasma ghrelin level was found to be lower in patients with obesity or diabetes in a few studies. However, there is no study comparing ghrelin level in non-diabetic and diabetic patients with overweight or obesity. We have two aims in this study; first to show whether plasma ghrelin levels in type 2 diabetes mellitus patients with excessive body mass index (BMI) decrease the level of a cumulative ghrelin which we expect in both diabetes-related and obesity-related conditions, secondly to study whether there is a correlation between ghrelin level and diabetes complications. Patients and Methods: Ethics committee decision and written informed consent from patients were received before the study. 57 BMI≥25 type 2 diabetic patients treated and followed up in the diabetic outpatient clinic and 25 BMI≥25 subjects without diabetes mellitus (control group) were included in this case-control study. Pregnant women, patients with malignancy and under 18 years old were excluded. The results were evaluated by the SPSS statistical program. Results: The ghrelin and BMI values of the diabetic patients with excessive BMI and the non-diabetic patients with excessive BMI were not statistically different. No statistical significant correlation between ghrelin and haemoglobin A1c (HbA1C), BMI, retinopathy, neuropathy, albuminuria, and macrovascular complications was found in the type 2 diabetic patients with overweight or obesity. Conclusion: The presence of diabetes in addition to patients with excessive BMI does not cause ghrelin levels to decrease more than expected.
{"title":"The effect of serum activated ghrelin hormone on glycemic control in the diabetic patients with excessive body mass index","authors":"Yilmaz Faki, Semih Kalyon","doi":"10.5472/marumj.1307861","DOIUrl":"https://doi.org/10.5472/marumj.1307861","url":null,"abstract":"Objective: In the literature, plasma ghrelin level was found to be lower in patients with obesity or diabetes in a few studies. However, \u0000there is no study comparing ghrelin level in non-diabetic and diabetic patients with overweight or obesity. We have two aims in this \u0000study; first to show whether plasma ghrelin levels in type 2 diabetes mellitus patients with excessive body mass index (BMI) decrease \u0000the level of a cumulative ghrelin which we expect in both diabetes-related and obesity-related conditions, secondly to study whether \u0000there is a correlation between ghrelin level and diabetes complications. \u0000Patients and Methods: Ethics committee decision and written informed consent from patients were received before the study. 57 \u0000BMI≥25 type 2 diabetic patients treated and followed up in the diabetic outpatient clinic and 25 BMI≥25 subjects without diabetes \u0000mellitus (control group) were included in this case-control study. Pregnant women, patients with malignancy and under 18 years old \u0000were excluded. The results were evaluated by the SPSS statistical program. \u0000Results: The ghrelin and BMI values of the diabetic patients with excessive BMI and the non-diabetic patients with excessive BMI were \u0000not statistically different. No statistical significant correlation between ghrelin and haemoglobin A1c (HbA1C), BMI, retinopathy, \u0000neuropathy, albuminuria, and macrovascular complications was found in the type 2 diabetic patients with overweight or obesity. \u0000Conclusion: The presence of diabetes in addition to patients with excessive BMI does not cause ghrelin levels to decrease more than \u0000expected.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48719588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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