Redwan Seid Busery, Bülent Mutlu, Dursun Akaslan, Emre Aslanger, Bedrettin Yildizeli, Halil Atas
Objective: We aimed to investigate the effect of right ventricular energy failure (RVEF) on hemodynamic and clinical outcomes in patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary endarterectomy (PEA) surgery or balloon pulmonary angioplasty (BPA). Patients and Methods: A total of 100 CTEPH patients planned for PEA or BPA were included in the study. Based on the presence of RVEF during diagnosis, patients divided into two groups. Hemodynamic data from right heart catheterization (RHC) were compared before and after procedures in 3-6 months follow up period. Results: Patients with RVEF revealed a decrease in mean pulmonary artery pressure (mPAP) 54.67±12.27 mmHg to 36.12±11.76 mmHg (p:
{"title":"The impact of right ventricular energy failure on the results of pulmonary endarterectomy and balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension","authors":"Redwan Seid Busery, Bülent Mutlu, Dursun Akaslan, Emre Aslanger, Bedrettin Yildizeli, Halil Atas","doi":"10.5472/marumj.1484403","DOIUrl":"https://doi.org/10.5472/marumj.1484403","url":null,"abstract":"Objective: We aimed to investigate the effect of right ventricular energy failure (RVEF) on hemodynamic and clinical outcomes in \u0000patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary endarterectomy (PEA) \u0000surgery or balloon pulmonary angioplasty (BPA). \u0000Patients and Methods: A total of 100 CTEPH patients planned for PEA or BPA were included in the study. Based on the presence of \u0000RVEF during diagnosis, patients divided into two groups. Hemodynamic data from right heart catheterization (RHC) were compared \u0000before and after procedures in 3-6 months follow up period. \u0000Results: Patients with RVEF revealed a decrease in mean pulmonary artery pressure (mPAP) 54.67±12.27 mmHg to 36.12±11.76 \u0000mmHg (p:","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Uprak, Mümin Coşkun, M. U. Ugurlu, Ömer Günal, A. Cingi, C. Yeğen
Objective: In obesity surgery, laparoscopic sleeve gastrectomy (LSG) is a frequently applied method. However, there are certain complications. Leakage is one of the most serious complications after surgery, causing postoperative morbidity and sometimes mortality. There is no consensus about management of leaks after LSG. In our study, we aimed to present our experience on the management of LSG leaks. Patients and Methods: Patients who underwent LSG between 2010-2017 in a tertiary university hospital were analyzed retrospectively. Demographic characteristics, endoscopic and surgical interventions, morbidity, and mortality rates of patients diagnosed with LSG leak were analyzed from prospectively recorded data. Results: Leak was observed in 11 (2.15%) of a total of 510 LSG patients. Six (54%) patients were diagnosed as acute and 5 were early leaks. Stent was applied to most of the patients (72%) with or without surgical exploration. The average length of stay in hospital was 21 days. Mortality was observed in 2 patients. Conclusions: Consequently, leakage after LSG is a complication that requires multimodal therapy. Surgical treatment combined with endoscopic intervention may increase success.
{"title":"Management of staple line leaks after laparoscopic sleeve gastrectomy: Single-center experience","authors":"T. Uprak, Mümin Coşkun, M. U. Ugurlu, Ömer Günal, A. Cingi, C. Yeğen","doi":"10.5472/marumj.1484454","DOIUrl":"https://doi.org/10.5472/marumj.1484454","url":null,"abstract":"Objective: In obesity surgery, laparoscopic sleeve gastrectomy (LSG) is a frequently applied method. However, there are certain \u0000complications. Leakage is one of the most serious complications after surgery, causing postoperative morbidity and sometimes \u0000mortality. There is no consensus about management of leaks after LSG. In our study, we aimed to present our experience on the \u0000management of LSG leaks. \u0000Patients and Methods: Patients who underwent LSG between 2010-2017 in a tertiary university hospital were analyzed retrospectively. \u0000Demographic characteristics, endoscopic and surgical interventions, morbidity, and mortality rates of patients diagnosed with LSG \u0000leak were analyzed from prospectively recorded data. \u0000Results: Leak was observed in 11 (2.15%) of a total of 510 LSG patients. Six (54%) patients were diagnosed as acute and 5 were early \u0000leaks. Stent was applied to most of the patients (72%) with or without surgical exploration. The average length of stay in hospital was \u000021 days. Mortality was observed in 2 patients. \u0000Conclusions: Consequently, leakage after LSG is a complication that requires multimodal therapy. Surgical treatment combined with \u0000endoscopic intervention may increase success.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to examine the effects of virtual reality (VR) usage on the eyes and investigate the parameters responsible
for the subsequent discomfort sensation.
Materials and Methods: This prospective study enrolled 20 healthy volunteers who were engaged in a 10-minute VR game session.
Refractive errors, kappa angles, phoria presence, accommodative responses, and scotopic, mesopic, and photopic pupillometry values
were recorded before and after using VR. A Virtual Reality Sickness Questionnaire (VRSQ) was applied to assess discomfort, and the
relation with evaluated parameters was investigated.
Results: Twenty volunteers (mean age 29.80±0.57 years) included 11 females (55%) and 9 males (45%). The mean spherical equivalent
refractive error was – 1.94±0.28 diopters and 5 (25%) volunteers had phoria. Average kappa angles were 0.23±0.02 mm (x-axis) and
0.11±0.01 mm (y-axis). Post-VR, the median [(interquartile range (IQR)] stereopsis decreased from 30 (30-60) to 60 (60-60) arc
seconds (P
目的:本研究旨在探讨虚拟现实(VR)使用对眼睛的影响，并探讨相关参数。对随后的不适感。
材料和方法:这项前瞻性研究招募了20名健康志愿者，他们参与了10分钟的VR游戏。屈光不正、卡帕角、斜视存在、适应性反应以及暗、中、光性瞳孔测量值
分别记录使用VR前后的情况。虚拟现实疾病问卷(VRSQ)用于评估不适，
考察了与评价参数的关系。
结果:20名志愿者(平均年龄29.80±0.57岁)，其中女性11人(55%)，男性9人(45%)。平均球当量
屈光不全为- 1.94±0.28屈光，有远视5例(25%)。平均kappa角为0.23±0.02 mm (x轴)和
0.11±0.01 mm (y轴)。vr后，立体视觉中位数[四分位间距(IQR)]从30(30-60)弧下降到60(60-60)弧
秒(P
{"title":"Effects of virtual reality usage on kappa angle, accommodation, pupil, depth perception, and examination of the relationship of these parameters with discomfort perception","authors":"Volkan DERİCİOĞLU, Betul KUBAT","doi":"10.5472/marumj.1378508","DOIUrl":"https://doi.org/10.5472/marumj.1378508","url":null,"abstract":"Objective: This study aims to examine the effects of virtual reality (VR) usage on the eyes and investigate the parameters responsible
 for the subsequent discomfort sensation.
 Materials and Methods: This prospective study enrolled 20 healthy volunteers who were engaged in a 10-minute VR game session.
 Refractive errors, kappa angles, phoria presence, accommodative responses, and scotopic, mesopic, and photopic pupillometry values
 were recorded before and after using VR. A Virtual Reality Sickness Questionnaire (VRSQ) was applied to assess discomfort, and the
 relation with evaluated parameters was investigated.
 Results: Twenty volunteers (mean age 29.80±0.57 years) included 11 females (55%) and 9 males (45%). The mean spherical equivalent
 refractive error was – 1.94±0.28 diopters and 5 (25%) volunteers had phoria. Average kappa angles were 0.23±0.02 mm (x-axis) and
 0.11±0.01 mm (y-axis). Post-VR, the median [(interquartile range (IQR)] stereopsis decreased from 30 (30-60) to 60 (60-60) arc
 seconds (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: We aimed to evaluate the complication rate and satisfaction status of patients who underwent otoplasty with the combined
Mustardé and Furnas sutures with minimal medial conchal cartilage excision.
Materials and Methods: Forty-four ears of 22 patients, operated for prominent ear deformity were retrospectively included in the
study. Patients were called for follow-up at various time intervals. At the sixth month, the patient and parents were asked to rate their
satisfaction with the operation on a scale of 1-10 and noted.
Results: The mean age of the patients was 8.09±2.72 years. The antihelix was created with Mustardé technique, minimal medial
conchal excisions were performed, two conchamastoid sutures were placed with Furnas technique. The mean follow-up period was
23.86±11.97 months. Complications developed in 4 of 44 ears (9%). Major complication rate was 4.5%. Two patients (4.5%) had suture
extrusion in one ear. None of the patients scored lower than 7 in the satisfaction questionnaire.
Conclusion: Otoplasty with a combination of cartilage-sparing techniques has low complication, revision, and high satisfaction rates.
Minimal medial conchal cartilage excision in addition to this technique is beneficial in reducing the conchamastoid tension and does
not increase the risk of complications.
{"title":"Combined Mustardé and Furnas type otoplasty with minimal conchal cartilage excision","authors":"Numan KOKTEN","doi":"10.5472/marumj.1378429","DOIUrl":"https://doi.org/10.5472/marumj.1378429","url":null,"abstract":"Objective: We aimed to evaluate the complication rate and satisfaction status of patients who underwent otoplasty with the combined
 Mustardé and Furnas sutures with minimal medial conchal cartilage excision.
 Materials and Methods: Forty-four ears of 22 patients, operated for prominent ear deformity were retrospectively included in the
 study. Patients were called for follow-up at various time intervals. At the sixth month, the patient and parents were asked to rate their
 satisfaction with the operation on a scale of 1-10 and noted.
 Results: The mean age of the patients was 8.09±2.72 years. The antihelix was created with Mustardé technique, minimal medial
 conchal excisions were performed, two conchamastoid sutures were placed with Furnas technique. The mean follow-up period was
 23.86±11.97 months. Complications developed in 4 of 44 ears (9%). Major complication rate was 4.5%. Two patients (4.5%) had suture
 extrusion in one ear. None of the patients scored lower than 7 in the satisfaction questionnaire.
 Conclusion: Otoplasty with a combination of cartilage-sparing techniques has low complication, revision, and high satisfaction rates.
 Minimal medial conchal cartilage excision in addition to this technique is beneficial in reducing the conchamastoid tension and does
 not increase the risk of complications.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135902478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuberculosis (TB) is a communicable disease that is a major cause of ill health. Urogenital TB was a frequent urological disease in the
pre-antibiotic era: about 20% of patients in urological hospitals had renal TB, mostly in the form of pyonephrosis.
We composed a narrative review of the literature with keywords “urogenital tuberculosis’, “prostate tuberculosis” “kidney tuberculosis”,
“treatment of tuberculosis”.
Urogenital TB (UGTB) includes TB of the kidney and the urinary tract and male and female genital TB. Each clinical presentation
requires tailored antibiotic therapy depending on stage and general management. Anti-TB therapy should be multicomponent,
continuous, long-lasting and controlled with a follow-up for 2-3 years. Otherwise, the risks of development of drug-resistance and
relapse increase.
Index of suspicion on UGTB is generally low, causing a delay in diagnosis; consequently, complicated forms of UGTB respond
poorly to anti-TB therapy, while timely diagnosed “minor” forms are curable medically without surgery. Even with timely diagnosed
UGTB, non-optimal therapy may result in over-fibrosis, scarring and strictures of the urinary tract, making surgical repair inevitable.
Nevertheless, we have a wide enough spectrum of anti-TB drugs to cure urogenital TB.
{"title":"The therapy for urogenital tuberculosis","authors":"Ekaterina KULCHAVENYA, Mete ÇEK","doi":"10.5472/marumj.1368375","DOIUrl":"https://doi.org/10.5472/marumj.1368375","url":null,"abstract":"Tuberculosis (TB) is a communicable disease that is a major cause of ill health. Urogenital TB was a frequent urological disease in the
 pre-antibiotic era: about 20% of patients in urological hospitals had renal TB, mostly in the form of pyonephrosis.
 We composed a narrative review of the literature with keywords “urogenital tuberculosis’, “prostate tuberculosis” “kidney tuberculosis”,
 “treatment of tuberculosis”.
 Urogenital TB (UGTB) includes TB of the kidney and the urinary tract and male and female genital TB. Each clinical presentation
 requires tailored antibiotic therapy depending on stage and general management. Anti-TB therapy should be multicomponent,
 continuous, long-lasting and controlled with a follow-up for 2-3 years. Otherwise, the risks of development of drug-resistance and
 relapse increase.
 Index of suspicion on UGTB is generally low, causing a delay in diagnosis; consequently, complicated forms of UGTB respond
 poorly to anti-TB therapy, while timely diagnosed “minor” forms are curable medically without surgery. Even with timely diagnosed
 UGTB, non-optimal therapy may result in over-fibrosis, scarring and strictures of the urinary tract, making surgical repair inevitable.
 Nevertheless, we have a wide enough spectrum of anti-TB drugs to cure urogenital TB.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to investigate the effect of contrast agent use on procedure time and accuracy in pulsed
radiofrequency treatment of the lumbar dorsal root ganglion.
Patients and Methods: Patients aged 23–79 years with lumbar radicular pain due to disc herniation for at least 3 months were randomized
into two groups of 35 patients each. Patients in both groups underwent fluoroscopy-guided pulsed radiofrequency treatment of the
dorsal root ganglion at the level of the L5 foramen. In the radiocontrast group, unlike the control group, the location of the ganglion
was determined by administering the contrast agent before the radiofrequency treatment.
Results: Procedure time in the radiocontrast group was significantly longer than in the control group (P< 0.05). In 50 cases ganglion
was detected in the extraforaminal or intraforaminal location, the excitation of the ganglion in the range of 0.4–0.6 V was significantly
higher in the radiocontrast group (95.8%) than in the control group (69.2%) (P< 0.05).
Conclusion: The use of radiocontrast material in pulsed radiofrequency application on the dorsal root ganglion prolongs the procedure
time. However, for ganglia that cannot be detected by stimulation, contrast injection is useful on procedural accuracy
{"title":"The role of radiocontrast agents in the pulsed radiofrequency treatment of lumbar dorsal root ganglion","authors":"Serdar KOKAR, Ozgur Emre POLAT","doi":"10.5472/marumj.1367781","DOIUrl":"https://doi.org/10.5472/marumj.1367781","url":null,"abstract":"Objective: The aim of this study was to investigate the effect of contrast agent use on procedure time and accuracy in pulsed
 radiofrequency treatment of the lumbar dorsal root ganglion.
 Patients and Methods: Patients aged 23–79 years with lumbar radicular pain due to disc herniation for at least 3 months were randomized
 into two groups of 35 patients each. Patients in both groups underwent fluoroscopy-guided pulsed radiofrequency treatment of the
 dorsal root ganglion at the level of the L5 foramen. In the radiocontrast group, unlike the control group, the location of the ganglion
 was determined by administering the contrast agent before the radiofrequency treatment.
 Results: Procedure time in the radiocontrast group was significantly longer than in the control group (P< 0.05). In 50 cases ganglion
 was detected in the extraforaminal or intraforaminal location, the excitation of the ganglion in the range of 0.4–0.6 V was significantly
 higher in the radiocontrast group (95.8%) than in the control group (69.2%) (P< 0.05).
 Conclusion: The use of radiocontrast material in pulsed radiofrequency application on the dorsal root ganglion prolongs the procedure
 time. However, for ganglia that cannot be detected by stimulation, contrast injection is useful on procedural accuracy","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Bacterial and fungal infections, antimicrobial resistance (AMR) results of bacterial agents, and the effect of the pandemic
on AMR were evaluated in hospitalized COVID-19 patients. In addition, the detected AMR rates were compared with the AMR rates
of the pre-pandemic period.
Patients and Methods: The isolates grown in respiratory and blood samples of adult patients hospitalized with the diagnosis of
COVID-19 between March 2020 and December 2020 were evaluated retrospectively. The same data in hospitalized patients before the
pandemic, between March and December 2019, were evaluated retrospectively.
Results: A total of 724 samples were included in the study. The superinfection rate was found to be 15.3%. The most frequently isolated
microorganisms are; Acinetobacter baumannii (34.4%), Staphylococcus aureus (10.8%), Klebsiella pneumoniae (9.7%) and Pseudomonas
aeruginosa (7.3%). The lowest resistance rates in Klebsiella pneumoniae isolates were found for aminoglycosides, in Acinetobacter
baumannii isolates were found for trimethoprim-sulfamethoxazole, in Pseudomonas aeruginosa isolates were found for amikacin.
When pre-pandemic and pandemic AMR rates were compared; a significant increase in amikacin resistance was detected only in
Klebsiella pneumoniae isolates during the pandemic period (P:0.049).
Conclusion: The data we have presented may help clinicians in the selection of antimicrobials for empirical therapy by revealing the
effect of the pandemic on AMR.
{"title":"Relationship between COVID-19 and antimicrobial resistance","authors":"Tuba MÜDERRİS, Selcuk KAYA, Fulya BAYINDIR BİLMAN, Erkan OZMEN, Bilal Olcay PEKER, Ayşegül AKSOY GÖKMEN, Süreyya GÜL YURTSEVER","doi":"10.5472/marumj.1367895","DOIUrl":"https://doi.org/10.5472/marumj.1367895","url":null,"abstract":"Objective: Bacterial and fungal infections, antimicrobial resistance (AMR) results of bacterial agents, and the effect of the pandemic
 on AMR were evaluated in hospitalized COVID-19 patients. In addition, the detected AMR rates were compared with the AMR rates
 of the pre-pandemic period.
 Patients and Methods: The isolates grown in respiratory and blood samples of adult patients hospitalized with the diagnosis of
 COVID-19 between March 2020 and December 2020 were evaluated retrospectively. The same data in hospitalized patients before the
 pandemic, between March and December 2019, were evaluated retrospectively.
 Results: A total of 724 samples were included in the study. The superinfection rate was found to be 15.3%. The most frequently isolated
 microorganisms are; Acinetobacter baumannii (34.4%), Staphylococcus aureus (10.8%), Klebsiella pneumoniae (9.7%) and Pseudomonas
 aeruginosa (7.3%). The lowest resistance rates in Klebsiella pneumoniae isolates were found for aminoglycosides, in Acinetobacter
 baumannii isolates were found for trimethoprim-sulfamethoxazole, in Pseudomonas aeruginosa isolates were found for amikacin.
 When pre-pandemic and pandemic AMR rates were compared; a significant increase in amikacin resistance was detected only in
 Klebsiella pneumoniae isolates during the pandemic period (P:0.049).
 Conclusion: The data we have presented may help clinicians in the selection of antimicrobials for empirical therapy by revealing the
 effect of the pandemic on AMR.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Neurogenic myocardial stunning is a type of stress-induced cardiomyopathy thought to be a result of dysregulation of the
autonomic nervous system. Heart rate variability (HRV) analysis is a potential method for understanding the underlying mechanisms
of autonomic dysfunction in ischemic stroke. The aim of the study was to investigate HRV in stroke patients in accordance with
troponin levels.
Patients and Methods: Sixty-six patients (mean age 65 ± 13 years; 39 male) presenting with acute ischemic stroke were consecutively
included. High-sensitive cardiac troponin I (hs-cTnI) levels were accepted as elevated when> 0.04 ng/mL. All patients underwent
ambulatory electrocardiographic (ECG) monitoring within the first seven days to obtain time-domain and frequency-domain
measures of HRV.
Results: Twenty patients (30.3 %) had elevated hs-cTnI. Patients with high troponin levels had significantly lower left ventricular
ejection fraction (LVEF), higher ST-segment-T wave changes, and higher N terminal pro-brain natriuretic peptide (NT-proBNP)
levels. Low-frequency/high-frequency (LF/HF) value was significantly higher in the troponin-positive group, but other ambulatory
ECG monitoring parameters such as SDNN, SDANN, RMSSD, and pNN50 were similar among patients.
Conclusion: Neurogenic myocardial damage presenting with high troponin levels can be seen in ischemic stroke patients and may be
associated with sympathetic overactivity.
{"title":"Heart rate variability of acute ischemic stroke patients according to troponin levels","authors":"Cigdem ILERI, Zekeriya DOGAN, Ipek MIDI","doi":"10.5472/marumj.1367390","DOIUrl":"https://doi.org/10.5472/marumj.1367390","url":null,"abstract":"Objective: Neurogenic myocardial stunning is a type of stress-induced cardiomyopathy thought to be a result of dysregulation of the
 autonomic nervous system. Heart rate variability (HRV) analysis is a potential method for understanding the underlying mechanisms
 of autonomic dysfunction in ischemic stroke. The aim of the study was to investigate HRV in stroke patients in accordance with
 troponin levels.
 Patients and Methods: Sixty-six patients (mean age 65 ± 13 years; 39 male) presenting with acute ischemic stroke were consecutively
 included. High-sensitive cardiac troponin I (hs-cTnI) levels were accepted as elevated when> 0.04 ng/mL. All patients underwent
 ambulatory electrocardiographic (ECG) monitoring within the first seven days to obtain time-domain and frequency-domain
 measures of HRV.
 Results: Twenty patients (30.3 %) had elevated hs-cTnI. Patients with high troponin levels had significantly lower left ventricular
 ejection fraction (LVEF), higher ST-segment-T wave changes, and higher N terminal pro-brain natriuretic peptide (NT-proBNP)
 levels. Low-frequency/high-frequency (LF/HF) value was significantly higher in the troponin-positive group, but other ambulatory
 ECG monitoring parameters such as SDNN, SDANN, RMSSD, and pNN50 were similar among patients.
 Conclusion: Neurogenic myocardial damage presenting with high troponin levels can be seen in ischemic stroke patients and may be
 associated with sympathetic overactivity.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Candidemia is a life-threatening infection that causes high mortality rates in intensive care units (ICUs). This study aims to
evaluate predictors of the outcome of patients with candidemia in ICU.
Patients and Methods: This observational, retrospective study included patients with Candida bloodstream infection (BSI) in ICUs
between 6 years of the episode. A binary logistic regression analysis was conducted to inspect the association with mortality.
Results: The median age of 74 patients was 68.5, and 53.8% were men. C. parapsilosis was the most frequently isolated fungal species.
The 30-day mortality rate was 50%. In the logistic regression model the Acute Physiology and Chronic Health Evaluation (APACHE)
II score, positive blood culture on the seventh day, inotropes needed on the day of blood culture positivity, and ventilator-associated
pneumonia (VAP) were significant risk factors for the outcome of patients. There was no difference in mortality between an early start
of antifungal treatment or central venous catheter removal time.
Conclusion: A shift to C. parapsilosis is observed in this study. Host-related factors such as APACHE II score, need for mechanical
ventilation or need for inotropes affect mortality more than early treatment and source control in patients with Candida BSI.
{"title":"Predictors of outcomes in patients with candidemia in an Intensive Care Unit","authors":"Ayşe Serra ÖZEL, Lütfiye Nilsun ALTUNAL, Buket Erturk SENGEL, Muge ASLAN, Mehtap AYDIN","doi":"10.5472/marumj.1367454","DOIUrl":"https://doi.org/10.5472/marumj.1367454","url":null,"abstract":"Objective: Candidemia is a life-threatening infection that causes high mortality rates in intensive care units (ICUs). This study aims to
 evaluate predictors of the outcome of patients with candidemia in ICU.
 Patients and Methods: This observational, retrospective study included patients with Candida bloodstream infection (BSI) in ICUs
 between 6 years of the episode. A binary logistic regression analysis was conducted to inspect the association with mortality.
 Results: The median age of 74 patients was 68.5, and 53.8% were men. C. parapsilosis was the most frequently isolated fungal species.
 The 30-day mortality rate was 50%. In the logistic regression model the Acute Physiology and Chronic Health Evaluation (APACHE)
 II score, positive blood culture on the seventh day, inotropes needed on the day of blood culture positivity, and ventilator-associated
 pneumonia (VAP) were significant risk factors for the outcome of patients. There was no difference in mortality between an early start
 of antifungal treatment or central venous catheter removal time.
 Conclusion: A shift to C. parapsilosis is observed in this study. Host-related factors such as APACHE II score, need for mechanical
 ventilation or need for inotropes affect mortality more than early treatment and source control in patients with Candida BSI.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gulsah Beyza ERTOSUN, Mehmet ERGEN, Hilal BARDAKCI, Timur Hakan BARAK, Guldal SUYEN
Objective: Current treatment of Alzheimer’s disease is provided by cholinesterase inhibitors. Salvia triloba L. (syn. Salvia fruticosa Mill.),
a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase
inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats
and rats with scopolamine induced memory impairment.
Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas
Chromatography-Mass Spectrometry (GC-MS). The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and
β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive
enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability
of 1,8-cineole in blood of rats was measured by GC-MS.
Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency
performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment.
Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting
cognitive functions.
{"title":"Cholinergic cognitive enhancer effect of Salvia triloba L. essential oil inhalation in rats","authors":"Gulsah Beyza ERTOSUN, Mehmet ERGEN, Hilal BARDAKCI, Timur Hakan BARAK, Guldal SUYEN","doi":"10.5472/marumj.1368345","DOIUrl":"https://doi.org/10.5472/marumj.1368345","url":null,"abstract":"Objective: Current treatment of Alzheimer’s disease is provided by cholinesterase inhibitors. Salvia triloba L. (syn. Salvia fruticosa Mill.),
 a species mostly consumed as refreshing herbal tea in traditional medicine, is rich in 1,8-cineole that is known to have cholinesterase
 inhibiting effects. In this study, we investigated cognitive enhancer effects of S. triloba essential oil inhalation on healthy control rats
 and rats with scopolamine induced memory impairment.
 Materials and Methods: S. triloba samples from different geographical locations of Turkey were hydro-distilled and analyzed by Gas
 Chromatography-Mass Spectrometry (GC-MS). The optimum sample with the highest 1,8-cineole and lowest camphor, α-thujone and
 β-thujone content was selected. In vitro cholinergic and antioxidant potentials of the selected essential oil were calculated. Cognitive
 enhancer and anti-amnestic effects of the inhaled essential oil on rats were assessed by means of Morris water maze. The bioavailability
 of 1,8-cineole in blood of rats was measured by GC-MS.
 Results: The group that inhaled S. triloba significantly outperformed control group, namely faster achieving peak escape latency
 performance in Morris water maze. However, S. triloba inhalation failed to restore scopolamine induced learning impairment.
 Conclusion: In this study, we report positive effects of inhaling S. triloba essential oil as a complementary treatment for supporting
 cognitive functions.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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