Objective: The study aims to investigate the use of pulmonary artery stiffness (PAS) parameter in early diagnosis of systemic sclerosis
(SSc) and pulmonary hypertension in SSc patients.
Patients and Methods: The study involved 102 SSc patients and 45 control group patients, who underwent transthoracic
echocardiographic evaluations.
Results: Pulmonary artery stiffness was measured as 25.7±7.6 (Hz/msn) in the SSc cases and 13.7 ±1.6 (Hz/msn) in the healthy
subjects (P< 0.001). TAPSE/sPAP ratio, which we used as an indicator of RV-PA coupling, was calculated as 0.65+0.28 in SSc cases and
1.12+0.33 in the control group (P
{"title":"Evaluation of pulmonary artery stiffness in patients with systemic sclerosis","authors":"Dursun AKASLAN, Murat DEMİRCİ","doi":"10.5472/marumj.1378484","DOIUrl":"https://doi.org/10.5472/marumj.1378484","url":null,"abstract":"Objective: The study aims to investigate the use of pulmonary artery stiffness (PAS) parameter in early diagnosis of systemic sclerosis
 (SSc) and pulmonary hypertension in SSc patients.
 Patients and Methods: The study involved 102 SSc patients and 45 control group patients, who underwent transthoracic
 echocardiographic evaluations.
 Results: Pulmonary artery stiffness was measured as 25.7±7.6 (Hz/msn) in the SSc cases and 13.7 ±1.6 (Hz/msn) in the healthy
 subjects (P< 0.001). TAPSE/sPAP ratio, which we used as an indicator of RV-PA coupling, was calculated as 0.65+0.28 in SSc cases and
 1.12+0.33 in the control group (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135487069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: During the COVID-19 pandemic, many patients have experienced cardiovascular complications, including a variety
of arrhythmias. The aim of our study was to evaluate the acute electrocardiography (ECG) changes and post-COVID arrhythmia
incidence in patients with acute COVID-19 infection.
Patients and Methods: One hundred hospitalized COVID-19 patients were consecutively included. Patients were divided into two
groups according to their troponin levels. Thirty subjects were included as controls. All patients underwent daily 12-lead ECG during
hospitalization and were followed up for at least 12 months, by performing ECG and ambulatory ECG monitoring and questioning
their symptoms at 3-month intervals.
Results: Thirty-one patients had elevated high sensitive cardiac troponin I (hs-cTnI). These patients had significantly longer QT
dispersion compared to COVID-19 patients with normal troponin levels and controls. Regardless of troponin elevation, COVID-19
patients had significantly longer Tp-e intervals and P wave (PW) durations compared to controls. During the follow-up period;
palpitation, beta-blocker usage, and inappropriate sinus tachycardia were more common in the COVID-19 group with hs-cTnI than
control group.
Conclusion: Our study did not find any relation between serum fibroblast growth factor-21 levels and carotid intima-media thickness.
Further researches with wider study population are needed.
{"title":"Acute ECG changes and post-COVID arrhythmia incidence in patients with acute COVID-19 infection","authors":"Zekeriya DOĞAN, Çiğdem İLERİ","doi":"10.5472/marumj.1378494","DOIUrl":"https://doi.org/10.5472/marumj.1378494","url":null,"abstract":"Objective: During the COVID-19 pandemic, many patients have experienced cardiovascular complications, including a variety
 of arrhythmias. The aim of our study was to evaluate the acute electrocardiography (ECG) changes and post-COVID arrhythmia
 incidence in patients with acute COVID-19 infection.
 Patients and Methods: One hundred hospitalized COVID-19 patients were consecutively included. Patients were divided into two
 groups according to their troponin levels. Thirty subjects were included as controls. All patients underwent daily 12-lead ECG during
 hospitalization and were followed up for at least 12 months, by performing ECG and ambulatory ECG monitoring and questioning
 their symptoms at 3-month intervals.
 Results: Thirty-one patients had elevated high sensitive cardiac troponin I (hs-cTnI). These patients had significantly longer QT
 dispersion compared to COVID-19 patients with normal troponin levels and controls. Regardless of troponin elevation, COVID-19
 patients had significantly longer Tp-e intervals and P wave (PW) durations compared to controls. During the follow-up period;
 palpitation, beta-blocker usage, and inappropriate sinus tachycardia were more common in the COVID-19 group with hs-cTnI than
 control group.
 Conclusion: Our study did not find any relation between serum fibroblast growth factor-21 levels and carotid intima-media thickness.
 Further researches with wider study population are needed.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan KAZDAĞLI, Şüheda ALPAY, Hasan Fehmi ÖZEL, Elif BARIŞ
Objective: Heart rate variability (HRV) is used to evaluate the autonomic activity of heartbeat. This study aimed to investigate the
effects of cholinomimetic drugs cytidine diphosphate-choline (CDP-choline) and choline, on short-term HRV parameters.
Materials and Methods: Animals were randomized into three groups; control (0.9% NaCl), choline (100 mg/kg), CDP-choline (400
mg/kg). Electrocardiography recordings were obtained for 45-minutes after treatments with 15-minutes intervals. HRV analyses and
total choline level measurements in serum and heart tissues were performed.
Results: High frequency power and total power increased in treatment groups, while heart rates were decreased. Low frequency was
decreased with choline while very low frequency power decreased with CDP-choline. Choline affected most of the HRV parameters
in the first 15 minutes, while the effect of CDP-choline started within 30 minutes. Total choline levels were higher in both treatment
groups than in the control while the levels were also higher in the choline group compared to CDP-choline group.
Conclusion: This study showed that CDP-choline and choline treatments produced a rapid response to short-term HRV parameters,
while increasing tissue choline levels. Moreover, the differences in effects and onset time between the drugs on HRV might be related
to tissue choline concentration.
{"title":"Evaluation of differential effects of CDP-choline and choline on parasympathetic activity and changes in choline levels with heart rate variability","authors":"Hasan KAZDAĞLI, Şüheda ALPAY, Hasan Fehmi ÖZEL, Elif BARIŞ","doi":"10.5472/marumj.1379856","DOIUrl":"https://doi.org/10.5472/marumj.1379856","url":null,"abstract":"Objective: Heart rate variability (HRV) is used to evaluate the autonomic activity of heartbeat. This study aimed to investigate the
 effects of cholinomimetic drugs cytidine diphosphate-choline (CDP-choline) and choline, on short-term HRV parameters.
 Materials and Methods: Animals were randomized into three groups; control (0.9% NaCl), choline (100 mg/kg), CDP-choline (400
 mg/kg). Electrocardiography recordings were obtained for 45-minutes after treatments with 15-minutes intervals. HRV analyses and
 total choline level measurements in serum and heart tissues were performed.
 Results: High frequency power and total power increased in treatment groups, while heart rates were decreased. Low frequency was
 decreased with choline while very low frequency power decreased with CDP-choline. Choline affected most of the HRV parameters
 in the first 15 minutes, while the effect of CDP-choline started within 30 minutes. Total choline levels were higher in both treatment
 groups than in the control while the levels were also higher in the choline group compared to CDP-choline group.
 Conclusion: This study showed that CDP-choline and choline treatments produced a rapid response to short-term HRV parameters,
 while increasing tissue choline levels. Moreover, the differences in effects and onset time between the drugs on HRV might be related
 to tissue choline concentration.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albena GAYEF, Ozge EMRE, Esra AKDENİZ, Mehmet Ali GÜLPINAR
Objective: The purpose of this research is to evaluate e-PBL tutorials and compare these sessions with face-to-face PBL sessions.
Patients and Methods: This research is a program evaluation study in which quantitative methods were used. In the research, four
90-minute e-PBL sessions held between April and June 2020 were evaluated. Sessions conducted online were realised using the sevenstep
approach in groups of 13-14 students and a tutor. Video recordings were analysed with the thin slicing method. In addition,
various quantitative data on evaluation were analysed using multiple tools and materials, including the end-of-program evaluation
form. Friedman test and Mann-Whitney U test were used in the analyses of quantitative data.
Results: Upon evaluating the analyses of the feedback received from the students about the structure, content and process of the
program regarding the e-PBL tutorials, the students gave a positive opinion of 80% or more. In regards with the cases, the students
had positive opinions of over 80% in terms of “motivation for learning and researching”, “daily life and its relation to their individual
development”, “suitability to their levels of knowledge and skills”, “reinforcement of topics”. Support, guidance and feedback received
from the tutor as a group and individually during online tutorials were statistically significantly higher than the face-to-face PBL
tutorials (P
{"title":"The evaluation of the processes of problem based learning tutorials: Online or face-to-face?","authors":"Albena GAYEF, Ozge EMRE, Esra AKDENİZ, Mehmet Ali GÜLPINAR","doi":"10.5472/marumj.1378475","DOIUrl":"https://doi.org/10.5472/marumj.1378475","url":null,"abstract":"Objective: The purpose of this research is to evaluate e-PBL tutorials and compare these sessions with face-to-face PBL sessions.
 Patients and Methods: This research is a program evaluation study in which quantitative methods were used. In the research, four
 90-minute e-PBL sessions held between April and June 2020 were evaluated. Sessions conducted online were realised using the sevenstep
 approach in groups of 13-14 students and a tutor. Video recordings were analysed with the thin slicing method. In addition,
 various quantitative data on evaluation were analysed using multiple tools and materials, including the end-of-program evaluation
 form. Friedman test and Mann-Whitney U test were used in the analyses of quantitative data.
 Results: Upon evaluating the analyses of the feedback received from the students about the structure, content and process of the
 program regarding the e-PBL tutorials, the students gave a positive opinion of 80% or more. In regards with the cases, the students
 had positive opinions of over 80% in terms of “motivation for learning and researching”, “daily life and its relation to their individual
 development”, “suitability to their levels of knowledge and skills”, “reinforcement of topics”. Support, guidance and feedback received
 from the tutor as a group and individually during online tutorials were statistically significantly higher than the face-to-face PBL
 tutorials (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Scleroderma (SSc) is a rare autoimmune tissue disease. There is currently no effective treatment for SSc. The aim of this
study was to investigate the antioxidant and anti-inflammatory effects of upadacitinib and PD29 on total oxidant status (TOS), total
antioxidant status (TAS), malondialdehyde (MDA), catalase (CAT), glutathione (GSH) peroxidase levels, and interleukin-6 (IL-6) and
interleukin-13 ( IL-13) in kidney tissues of an experimental SSc model.
Materials and Methods: The experimental design was established with five groups of eight mice: Control, bleomycin (BLM) (5 μg/kg),
BLM + upadacitinib (3mg/kg), BLM + PD29 (5 mg/kg) and BLM + PD29 + upadacitinib group. BLM was administered subcutaneously
once a day for 21 days. PD29 was administered subcutaneously and upadacitinib (gavage) were injected for 21 days. Renal tissues were
collected at the end of the experiment. Renal TOS, TAS, MDA, CAT, GSH levels, and IL-6 and IL-13 gene expressions were evaluated.
Results: Upadacitinib and PD29 affected oxidant status and TOS. MDA levels decreased, and GSH, CAT, and TAS levels increased.
Also, upadacitinib and PD29 decreased inflammation via IL-6 and IL-13 cytokines.
Conclusion: Upadacitinib and PD29 may have therapeutic roles for SSc renal crisis.
{"title":"Effects of upadacitinib and PD29 on oxidative damage and inflammation in bleomycin-induced scleroderma model kidney tissues","authors":"Ayşe KOÇAK, Meliha KOLDEMİR GÜNDÜZ, Güllü KAYMAK, Elif AYDIN","doi":"10.5472/marumj.1381649","DOIUrl":"https://doi.org/10.5472/marumj.1381649","url":null,"abstract":"Objective: Scleroderma (SSc) is a rare autoimmune tissue disease. There is currently no effective treatment for SSc. The aim of this
 study was to investigate the antioxidant and anti-inflammatory effects of upadacitinib and PD29 on total oxidant status (TOS), total
 antioxidant status (TAS), malondialdehyde (MDA), catalase (CAT), glutathione (GSH) peroxidase levels, and interleukin-6 (IL-6) and
 interleukin-13 ( IL-13) in kidney tissues of an experimental SSc model.
 Materials and Methods: The experimental design was established with five groups of eight mice: Control, bleomycin (BLM) (5 μg/kg),
 BLM + upadacitinib (3mg/kg), BLM + PD29 (5 mg/kg) and BLM + PD29 + upadacitinib group. BLM was administered subcutaneously
 once a day for 21 days. PD29 was administered subcutaneously and upadacitinib (gavage) were injected for 21 days. Renal tissues were
 collected at the end of the experiment. Renal TOS, TAS, MDA, CAT, GSH levels, and IL-6 and IL-13 gene expressions were evaluated.
 Results: Upadacitinib and PD29 affected oxidant status and TOS. MDA levels decreased, and GSH, CAT, and TAS levels increased.
 Also, upadacitinib and PD29 decreased inflammation via IL-6 and IL-13 cytokines.
 Conclusion: Upadacitinib and PD29 may have therapeutic roles for SSc renal crisis.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve BAŞALAN, Mümtaz TAKIR, Cündullah TORUN, Medeni SERMET
Objective: We aimed to evaluate the effectiveness of laparoscopic sleeve gastrectomy (LSG) as a treatment method for morbid obesity
and its impact on reducing the incidence of metabolic syndrome and its components.
Patients and Methods: This retrospective and a single-center study included patients with obesity who underwent LSG and were
followed up at an endocrinology and metabolism outpatient clinic for at least one year. Anthropometric measurements, blood pressure,
and blood examinations including fasting plasma glucose and lipid profile were assessed before the surgery and one year after the
surgery. The presence of metabolic syndrome and related comorbidities was documented.
Results: The study included 62 patients, with a mean age of 38.2 ± 8 years and a female predominance (88.7%). At one year post-surgery,
significant improvements were observed in body weight, waist circumference, blood pressure, and metabolic parameters (P
{"title":"The effect of laparoscopic sleeve gastrectomy on metabolic syndrome parameters during one year of follow-up","authors":"Merve BAŞALAN, Mümtaz TAKIR, Cündullah TORUN, Medeni SERMET","doi":"10.5472/marumj.1381218","DOIUrl":"https://doi.org/10.5472/marumj.1381218","url":null,"abstract":"Objective: We aimed to evaluate the effectiveness of laparoscopic sleeve gastrectomy (LSG) as a treatment method for morbid obesity
 and its impact on reducing the incidence of metabolic syndrome and its components.
 Patients and Methods: This retrospective and a single-center study included patients with obesity who underwent LSG and were
 followed up at an endocrinology and metabolism outpatient clinic for at least one year. Anthropometric measurements, blood pressure,
 and blood examinations including fasting plasma glucose and lipid profile were assessed before the surgery and one year after the
 surgery. The presence of metabolic syndrome and related comorbidities was documented.
 Results: The study included 62 patients, with a mean age of 38.2 ± 8 years and a female predominance (88.7%). At one year post-surgery,
 significant improvements were observed in body weight, waist circumference, blood pressure, and metabolic parameters (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Muscarinic receptors (M1-M5) are members of the G protein-coupled receptor superfamily and are effective in physiological
functions through G proteins. Recent studies suggested that cholinergic receptors mediate cellular activities in hematopoietic cells.
The aim of this study was to investigate the potential role of mitogen-activated protein kinases (MAPK) signaling extracellular signalregulated
kinases 1 and 2 (ERK1/2)/phosphorylated ERK1/ (pERK1/2) pathways in chronic myeloid leukemia (K562) cells.
Materials and Methods: Chronic myeloid leukemia cells were cultured. Cells were incubated in the presence of muscarinic receptor
agonist, antagonist and epidermal growth factor (EGF). To detect MAPK activation, ERK/pERK protein expression levels were
determined by western blot method techniques.
Results: Our study results showed that cholinergic agents and EGFs affect the MAPK pathway in the human K562 cell line.
Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells.
Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells.
目的:毒蕈碱受体(M1-M5)是G蛋白偶联受体超家族的成员，在生理上起作用;通过G蛋白发挥作用最近的研究表明，胆碱能受体介导造血细胞的细胞活动。本研究的目的是探讨丝裂原活化蛋白激酶(MAPK)信号传导细胞外信号的潜在作用。激酶1和2 (ERK1/2)/磷酸化ERK1/ (pERK1/2)通路在慢性髓性白血病(K562)细胞中的作用。
材料与方法:培养慢性髓系白血病细胞。细胞在毒蕈碱受体
存在下孵育;激动剂，拮抗剂和表皮生长因子(EGF)。检测MAPK激活，ERK/pERK蛋白表达水平为
western blot法测定。
结果:我们的研究结果显示，胆碱能药物和EGFs影响人K562细胞系MAPK通路。
结论:胆碱能受体和EGF受体可能影响K562细胞的MAPK通路。结论:胆碱能受体和EGF受体可能影响K562细胞的MAPK通路。
{"title":"The role of epidermal growth factor and cholinergic receptor agonists and antagonists in MAPK signal transduction in K562 cells","authors":"Selda GÜLER ATMACA, Banu AYDIN, Hulya CABADAK","doi":"10.5472/marumj.1379868","DOIUrl":"https://doi.org/10.5472/marumj.1379868","url":null,"abstract":"Objective: Muscarinic receptors (M1-M5) are members of the G protein-coupled receptor superfamily and are effective in physiological
 functions through G proteins. Recent studies suggested that cholinergic receptors mediate cellular activities in hematopoietic cells.
 The aim of this study was to investigate the potential role of mitogen-activated protein kinases (MAPK) signaling extracellular signalregulated
 kinases 1 and 2 (ERK1/2)/phosphorylated ERK1/ (pERK1/2) pathways in chronic myeloid leukemia (K562) cells.
 Materials and Methods: Chronic myeloid leukemia cells were cultured. Cells were incubated in the presence of muscarinic receptor
 agonist, antagonist and epidermal growth factor (EGF). To detect MAPK activation, ERK/pERK protein expression levels were
 determined by western blot method techniques.
 Results: Our study results showed that cholinergic agents and EGFs affect the MAPK pathway in the human K562 cell line.
 Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells.
 Conclusion: Cholinergic and EGF receptors may affect the MAPK pathway in K562 cells.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135621217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eye movement desensitization and reprocessing (EMDR) is a psychotherapy that helps people to heal from trauma or other
disturbing life experiences. In this article, the appearance of nystagmus in the eye during the application of the EMDR method
was discussed while treating a 16-year-old adolescent girl who presented with a complaint of not eating meat following a
traumatic event. Although, eye movements are used in EMDR, nystagmus can impede the patient’s ability to maintain eye
movements. After excluding additional pathologies related to the eye, alternative bilateral stimulations can be used in EMDR.
{"title":"End-point nystagmus and EMDR","authors":"Borte GURBUZ OZGUR, Erdogan OZGUR, Mujdat KARABULUT","doi":"10.5472/marumj.1379885","DOIUrl":"https://doi.org/10.5472/marumj.1379885","url":null,"abstract":"Eye movement desensitization and reprocessing (EMDR) is a psychotherapy that helps people to heal from trauma or other
 disturbing life experiences. In this article, the appearance of nystagmus in the eye during the application of the EMDR method
 was discussed while treating a 16-year-old adolescent girl who presented with a complaint of not eating meat following a
 traumatic event. Although, eye movements are used in EMDR, nystagmus can impede the patient’s ability to maintain eye
 movements. After excluding additional pathologies related to the eye, alternative bilateral stimulations can be used in EMDR.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emre KUDU, Sena Özge ASLAN, Dilan GENÇ, Oğuzhan DEMİR, Arzu DENİZBAŞI
Ectopic pregnancy is the implantation of the developing embryo outside the uterine cavity. It usually occurs in the fallopian tubes. One
of the critical complications of ectopic pregnancy is rupture. The most common symptoms of ectopic pregnancy rupture are vaginal
bleeding and abdominal pain. In atypical presentations, the diagnosis is based on suspicion. Herein, we presented a case of ruptured
ectopic pregnancy with an atypical presentation. The diagnosis of ruptured ectopic pregnancy should be considered when women with
childbearing potential apply to the emergency department.
{"title":"Successful diagnosis of a ruptured ectopic pregnancy: A woman without abdominal pain and vaginal bleeding","authors":"Emre KUDU, Sena Özge ASLAN, Dilan GENÇ, Oğuzhan DEMİR, Arzu DENİZBAŞI","doi":"10.5472/marumj.1379879","DOIUrl":"https://doi.org/10.5472/marumj.1379879","url":null,"abstract":"Ectopic pregnancy is the implantation of the developing embryo outside the uterine cavity. It usually occurs in the fallopian tubes. One
 of the critical complications of ectopic pregnancy is rupture. The most common symptoms of ectopic pregnancy rupture are vaginal
 bleeding and abdominal pain. In atypical presentations, the diagnosis is based on suspicion. Herein, we presented a case of ruptured
 ectopic pregnancy with an atypical presentation. The diagnosis of ruptured ectopic pregnancy should be considered when women with
 childbearing potential apply to the emergency department.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase
chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19).
Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both
chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was
calculated and data were matched with PCR results.
Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR
results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%,
265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%)
patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group
Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be
the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test
results, ensuring infection prevention and control measures can be preserved.
目的:探讨胸部计算机断层扫描(CT)与逆转录聚合酶(rase)的诊断价值;链式反应(RT-PCR)在门诊疑似冠状病毒病2019 (COVID-19)中的应用。
患者和方法:在2020年3月至6月期间，共有812例临床疑似COVID-19患者接受了
回顾性纳入门诊入院时的胸部CT和初始单次RT-PCR。CT严重程度评分(CT- ss)为
计算和数据与PCR结果吻合。
结果:812例患者中，54%(439/812)的RT-PCR结果呈阳性，47%(425/812)的胸部CT扫描呈阳性。用rt - pcr # x0D;结果作为参考，胸部CT诊断COVID-19感染的敏感性、特异性、准确性为60%，(95% CI 56 ~ 65%，
265/439例患者)，57% (95% CI 52-62%， 213/373)， 59% (95% CI 55-62%， 478/812)。387 (47%)
未见CT表现，轻度380/812例(46.8%)，中度45/812例(5.5%)，重度组无患者;结论:胸部CT对门诊患者COVID-19的诊断敏感性不高。我们建议RT-PCR应该
主诊断工具。如果临床怀疑强烈且反复出现RT-PCR阴性，可考虑胸部CT检查
结果:确保感染防控措施得以保留。
{"title":"Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19","authors":"Elif TÜKENMEZ TİGEN, Buket ERTURK SENGEL, Canan CİMSİT, Hande PERK GURUN, Çiğdem APAYDIN KAYA, Volkan KORTEN","doi":"10.5472/marumj.1379916","DOIUrl":"https://doi.org/10.5472/marumj.1379916","url":null,"abstract":"Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase
 chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19).
 Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both
 chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was
 calculated and data were matched with PCR results.
 Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR
 results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%,
 265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%)
 patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group
 Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be
 the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test
 results, ensuring infection prevention and control measures can be preserved.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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