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The relationship between renal functions and multi-drug resistant organisms in patients with ventilator-associated pneumonia 呼吸机相关性肺炎患者肾功能与多药耐药菌的关系
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244732
Omur Ilban, Aysegul Ilban
Objective: Despite the increase in the frequency of multi-drug resistant organism (MDRO) colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant (MDR) pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia (VAP) and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of (eGFR) ≥ 60 mL/ min/1.73 m2 (high eGFR, n=65) and eGFR < 60 mL/min/1.73 m2 (low eGFR, n=68). Results: The low eGFR group presented a significantly high MDRO ratio (p
目的:尽管透析患者中多药耐药菌(MDRO)定植和感染的频率增加,但不进行透析的轻至重度慢性肾病患者发生多药耐药(MDR)肺炎的风险是否增加尚不清楚。因此,我们旨在评估肾功能与MDR呼吸机相关性肺炎(VAP)风险和特定微生物模式之间的关系。患者和方法:133例VAP患者根据肾功能分为肾小球滤过率(eGFR)≥60 mL/min/1.73 m2(高eGFR, n=65)和eGFR < 60 mL/min/1.73 m2(低eGFR, n=68)两组。结果:低eGFR组MDRO比值显著增高(p
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引用次数: 0
Evaluation of autonomic nervous system functions by using tilt table test and heart rate variability in epileptic children 应用倾斜试验和心率变异性评价癫痫患儿自主神经系统功能
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244552
Azad Redjepov, Sinem Altunyuva Usta, Y. Yildirim, F. Akalın
Objective: The value of head-up tilt test (HUTT) for differential diagnosis of epilepsy and the autonomic nervous system functions in epileptic children using heart rate variability (HRV) are studied. Patients and Methods: The study group consisted of 16 children with idiopatic/criptogenic epilepsy and 12 controls. Heart rate, PR interval, corrected QT (QTc) interval, QT and QTc dispersion were calculated using 12-lead electrocardiogram (ECG), HRV analysis was performed using the Holter recordings obtained both during HUTT and throughout the day. Time domain parameters, standard deviation of all RR intervals (SDNN), the standard deviation of mean NN intervals in five-minutes recording (SDANN), mean standard deviation of NN intervals in five-minutes recordings (SDNNi), root mean square of successive differences (RMSSD), count divided by the total number of all NN intervals (pNN50) and frequency domain parameters low frequency (LF), high frequency (HF), lowfrequency/ high-frequency ratio (LF/HF) were calculated in both and compared between the two groups. Results: Head-up tilt test was positive in 4 epileptic children (25%), none of controls were positive. The heart rate of the patients were higher than the controls (p=0.015). LF/HF ratio in 24-hour Holter recordings, were significantly lower (1.13±0.6, 1.83±0.7 respectively, p=0.002); the SDANN during HUTT (28.7±20.2, 18.2 ± 19.9 respectively, p=0.024) were significantly higher in the patients than the controls. Conclusion: Head-up tilt test positivity is frequent in epileptic children, and cannot be used in differential diagnosis. HRV calculated both from 24 hour Holter recordings and Holter recordings under orthostatic stress were impaired in favour of parasympathetic system in epileptic children.
目的:利用心率变异性(HRV)研究抬头倾斜试验(HUTT)在癫痫鉴别诊断和癫痫儿童自主神经系统功能方面的价值。患者和方法:研究组包括16名特发性/脚本性癫痫儿童和12名对照组。使用12导联心电图(ECG)计算心率、PR间期、校正QT(QTc)间期、QT和QTc离散度,使用HUTT期间和全天获得的Holter记录进行HRV分析。时域参数、所有RR间期的标准差(SDNN)、五分钟记录中的平均NN间期的标准偏差(SDNN,计算两组患者的心率、高频(HF)、低频/高频比(LF/HF)并在两组之间进行比较。结果:4例癫痫患儿(25%)的抬头倾斜试验呈阳性,对照组无一例呈阳性。患者的心率高于对照组(p=0.015)。24小时动态心电图记录的LF/HF比值显著低于对照组(分别为1.13±0.6、1.83±0.7,p=0.002);HUTT期间患者的SDNN(分别为28.7±20.2、18.2±19.9,p=0.024)显著高于对照组。结论:癫痫患儿抬头倾斜试验阳性率高,不能用于鉴别诊断。根据24小时动态心电图记录和直立应激下的动态心电图记录计算的HRV受损,有利于癫痫儿童的副交感神经系统。
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引用次数: 0
The effect of preemptive use of plerixafor on stem cell mobilization in patients with lymphoma and multiple myeloma 普立沙福对淋巴瘤和多发性骨髓瘤患者干细胞动员的影响
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244684
A. Uysal, M. Erkurt, Irfan Kuru, E. Kaya, İ. Berber, A. Sarici, S. Biçim, Ahmet Kaya, Emine Hidayet
ABSTRACT Objective: The aim of this study is to investigate the effect of the preemptive use of plerixafor in patients with lymphoma and multiple myeloma which was administered as a preemptive single dose to the patients who were determined to have a CD34+ cell count of
【摘要】目的:本研究的目的是探讨在淋巴瘤和多发性骨髓瘤患者中预先使用普利沙福的效果,该患者被确定为CD34+细胞计数
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引用次数: 0
Molecular analysis of human adenoviral keratoconjunctivitis cases: Results of a 2-year survey 人类腺病毒性角结膜炎病例的分子分析:2年调查结果
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244369
Ayfer Guner, Rabia Can Sarınoğlu, F. Aydin, S. Akkaya Turhan, M. Kuşkucu, A. E. Toker, Aysegul Karahasan Yagci
Objective: This study aimed to determine the adenovirus genotypes and their epidemiological features between January 2018 and November 2019, in Istanbul, Turkey. Material and Methods: Conjunctival swab samples were obtained from patients who were clinically diagnosed with keratoconjunctivitis. Samples were screened with an Adeno Detector kit (Rapid Pathogen Screening, RPS Inc., South Williamsport, PA). Nucleic acid extraction and amplification were performed with the ADENOVIRUS ELITe MGB® kit in the ELITe In Genius instrument (Elitech Group, Torino, Italy). For subtyping of the strains, sequencing primers targeted the ‘Hypervariable Region 7’ (HVR-7) of the hexon gene were used. DNA sequence analysis (n:72) was performed with ABI PRISM® 3100 Genetic Analyzer (Applied Biosystems, USA), and subtyping was done by BLAST analysis. Results: The median viral load in the samples (n: 77) was 7 log10 copies/mL (IQR: 4.5-7.4 log10 copies/mL). The clinical finding score was found to be significantly higher in the high viral load group (Adenovirus DNA≥6 Log 10 copies/mL) than in the low viral load group (Adenovirus DNA
目的:了解2018年1月至2019年11月土耳其伊斯坦布尔地区腺病毒基因型及其流行病学特征。材料和方法:从临床诊断为角膜结膜炎的患者中获得结膜拭子样本。样品用腺病毒检测试剂盒(快速病原体筛选,RPS公司,South Williamsport, PA)筛选。在ELITe in Genius仪器(ELITe Group, Torino, Italy)中使用腺病毒ELITe MGB®试剂盒进行核酸提取和扩增。采用针对六邻体基因“高变区7”(HVR-7)的测序引物进行分型。DNA序列分析(n:72)使用ABI PRISM®3100遗传分析仪(Applied Biosystems, USA)进行,并通过BLAST分析进行分型。结果:样本(n: 77)的中位病毒载量为7 log10拷贝/mL (IQR: 4.5-7.4 log10拷贝/mL)。高病毒载量组(腺病毒DNA≥6 Log 10拷贝/mL)的临床表现评分明显高于低病毒载量组(腺病毒DNA)
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引用次数: 0
Effect of angiotensin receptor-neprilysin inhibitor treatment on erectile dysfunction in heart failure with a reduced ejection fraction 血管紧张素受体-奈普利素抑制剂治疗心力衰竭伴射血分数降低患者勃起功能障碍的影响
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244456
S. Sert, E. Karabay, B. Gungor, O. Yildirimturk
Objective: Erectile dysfunction (ED) is a common condition in patients with heart failure (HF), which impairs quality of life. Our study aimed to compare those patients, who received traditional treatment with a diagnosis of HF and those who received angiotensin receptor-neprilysin inhibitor (ARNI) treatment in addition to the current treatment, in terms of ED at the end of 6 months. Patients and Methods: The study was planned as a single-center, prospective study. The study included 200 patients with heart failure. The patients’ demographic, clinical, and echocardiographic characteristics were recorded, and an international ED scoring questionnaire was applied. The participants in the study were divided into two groups: those who received ARNI treatment and those who did not. After 6 months, the ED questionnaire was applied to the patients again and the groups were compared. Results: The median age of the patients was 53 (years). The median ejection fraction (EF) value was calculated to be 30% and no significant difference was found between the groups (p: 0.122). It was found that N-terminal pro-brain natriuretic peptide (NT-pro- BNP) levels measured at the end of the 6th month were significantly lower in patients who had received ARNI treatment than in those who had not (respectively, 245 pg/ml, 200 pg/ml; p: 0.003). In the analysis performed to detect the presence of ED, it was discovered that the ED score change was significantly higher in the group that had received 6 months of ARNI treatment (p: 0.031) compared to that in the group that had not (p: 0.031). When the ED sub-parameters were compared in terms of the 6-month change rate, it was found that the ARNI group had a significant increase in terms of ED and sexual satisfaction scores, but no significant difference was found in the other parameters (p: 0.001, p: 0.029). Conclusion: Erectile dysfunction is more common in patients with heart failure compared to the rest of society and impairs quality of life. In our study, it was determined that ED complaints decreased significantly in HF patients, who had received ARNI treatment for 6 months than in patients who had not.
目的:勃起功能障碍(ED)是心力衰竭(HF)患者的常见病,严重影响患者的生活质量。我们的研究旨在比较那些接受传统治疗并诊断为HF的患者和在目前治疗的基础上接受血管紧张素受体-奈泼利素抑制剂(ARNI)治疗的患者在6个月后的ED情况。患者和方法:本研究计划为单中心前瞻性研究。该研究包括200名心力衰竭患者。记录患者的人口学、临床和超声心动图特征,并采用国际ED评分问卷。研究参与者被分为两组:接受ARNI治疗的组和未接受ARNI治疗的组。6个月后,再次对患者进行ED问卷调查,并进行组间比较。结果:患者中位年龄53岁。计算射血分数(EF)中位值为30%,两组间无显著差异(p: 0.122)。研究发现,在第6个月结束时,接受ARNI治疗的患者的n端前脑利钠肽(NT-pro- BNP)水平显著低于未接受ARNI治疗的患者(分别为245 pg/ml、200 pg/ml;p: 0.003)。在检测ED存在的分析中,发现接受6个月ARNI治疗组的ED评分变化明显高于未接受ARNI治疗组(p: 0.031)。当ED子参数以6个月变化率进行比较时,发现ARNI组在ED和性满意度评分方面显著增加,但在其他参数方面无显著差异(p: 0.001, p: 0.029)。结论:与其他人群相比,心力衰竭患者勃起功能障碍更为常见,并影响生活质量。在我们的研究中,我们确定接受ARNI治疗6个月的HF患者ED主诉比未接受ARNI治疗的患者显著减少。
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引用次数: 1
Are neighborhood characteristics associated with physical activity levels among school children? 社区特征与学龄儿童的体育活动水平有关吗?
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244381
Gülin Kaya, P. Ay, S. Hıdıroğlu
Objective: The objective of this study was to determine the prevalence of insufficient physical activity (IPA) and neighborhood characteristics associated with it, among school children. The impact of sociodemographic characteristics and ownership of electronic devices on physical activity (PA) were also evaluated. Materials and Methods: This was a cross-sectional study carried out among 5-7th grade students attending schools and their parents. IPA was defined as having moderate-vigorous activity for 0.05). Conclusion: The prevalence of IPA is alarmingly high among school children. The impact of neighborhood characteristics on PA might be obscured since both variables were measured subjectively. Devices related information/communication technologies increase IPA; we need to find novel ways to use these devices for PA promotion. There is also a need to increase structured PA opportunities.
目的:本研究的目的是确定在校儿童中身体活动不足(IPA)的患病率及其相关的社区特征。社会人口学特征和电子设备拥有量对身体活动(PA)的影响也进行了评估。材料与方法:本研究为横断面调查,调查对象为在校5-7年级学生及其家长。IPA定义为中度剧烈活动(0.05)。结论:IPA在学龄儿童中的患病率高得惊人。邻域特征对PA的影响可能会被模糊,因为这两个变量都是主观测量的。设备相关的信息/通信技术增加IPA;我们需要找到新的方法来使用这些设备进行PA推广。还需要增加结构化PA的机会。
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引用次数: 0
Medical students’ knowledge of the disease, frequency of depression, anxiety, stress symptoms, and related factors in the COVID-19 pandemic: A web-based questionnaire 医学生对疾病的了解、新冠肺炎大流行中抑郁、焦虑、压力症状的频率和相关因素:基于网络的问卷调查
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244747
Esra Çınar Tanrıverdi, M. Bayraktar, Suat Sincan, K. Kaşali, Y. Çayır, Mine Sahingoz, Z. Ozkurt
Objective: In this study, it was aimed to determine the level of knowledge of medical students about coronavirus disease 2019 (COVID-19), to investigate the frequency of depression, anxiety, stress symptoms and related factors. Materials and Methods: The study is a cross-sectional study conducted with 904 volunteer medical students. Data were collected with an online questionnaire, including sociodemographic characteristics, knowledge about COVID-19, the Depression, Anxiety, and Stress Scale. Results: Mean age was 21.3±2.2 years, and 54% of them (n=488) were female. Fifty five percent (n=497) thought that their level of knowledge about COVID-19 was sufficient, and 94.6% (n=846) were concerned about the disruption of their education. Their knowledge level was found to be 15.09±2.43 points out of 23 points. The depression, anxiety and stress symptoms were found in 64.9%, 70.4% and 34.1% of participants, respectively. The risk of anxiety (OR=0.51, 95%CI=0.94, p=0.020) and depression (OR=0.95, 95%CI=1.15, p=0.025) were higher in women. Those with a high fear of transmitting the COVID-19 infection to their relatives had higher symptoms of depression, anxiety, and stress. (p
目的:了解医学生对2019冠状病毒病(新冠肺炎)的认知水平,了解其抑郁、焦虑、应激症状的发生频率及相关因素。材料和方法:这项研究是一项横断面研究,共有904名志愿医学生参加。通过在线问卷收集数据,包括社会人口学特征、新冠肺炎知识、抑郁、焦虑和压力量表。结果:平均年龄21.3±2.2岁,其中女性占54%(n=488)。55%(n=497)认为他们对新冠肺炎的了解水平足够,94.6%(n=846)担心他们的教育受到干扰。他们的知识水平在23分中为15.09±2.43分。抑郁、焦虑和压力症状分别占64.9%、70.4%和34.1%。女性焦虑(OR=0.51,95%CI=0.94,p=0.020)和抑郁(OR=0.95,95%CI=1.15,p=0.025)的风险更高。那些高度害怕将新冠肺炎感染传染给亲属的人有更高的抑郁、焦虑和压力症状。(p
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引用次数: 0
The effects of mean platelet volume and red cell distribution width on prognosis in patients with myelodysplastic syndrome 骨髓增生异常综合征患者血小板平均体积和红细胞分布宽度对预后的影响
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244731
Ihsan Ayhan, Ş. Ertop
Objective: In this study, the relationship between changes in mean platelet volume (MPV) and erythrocyte distribution width (RDW) with hematological response and survival in patients with myelodysplastic syndrome was investigated. Patients and Methods: Between 1 January 2011 and 31 December 2018, patient characteristics and hemogram results were evaluated during the treatment process among 158 patients diagnosed with myelodysplastic syndrome. Results: The mean age of the patients who were included in the study was 71.53±12.6 years. The MPV percentage change in the 2-year follow-up of the patients with and without hematological response was significant, at 0.022±0.11 (2.2%) in those who responded and at 0.069±0.15 (6.9%) in those who did not (p=0.049). Throughout the same period, the degree of RDW changes in the patients who died was 13.23±22.97, the degree in those who survived was 2.86±21.42, and the difference between the two groups was statistically significant (p=0.006). Conclusion: In patients diagnosed with myelodysplastic syndrome, MPV and RDW values can be considered inexpensive and simple laboratory markers that can be used in follow-ups and promising tests to predict both treatment response and survival in the early period and change treatment modalities.
目的:本研究探讨骨髓增生异常综合征患者平均血小板体积(MPV)和红细胞分布宽度(RDW)变化与血液学反应和生存的关系。患者和方法:在2011年1月1日至2018年12月31日期间,对158例诊断为骨髓增生异常综合征的患者在治疗过程中的患者特征和血像结果进行了评估。结果:纳入研究的患者平均年龄为71.53±12.6岁。在2年随访中,有和无血液学反应的患者MPV百分比变化显著,有反应的患者为0.022±0.11(2.2%),无反应的患者为0.069±0.15 (6.9%)(p=0.049)。同期,死亡患者的RDW变化程度为13.23±22.97,存活患者的RDW变化程度为2.86±21.42,两组差异有统计学意义(p=0.006)。结论:在诊断为骨髓增生异常综合征的患者中,MPV和RDW值可以被认为是廉价和简单的实验室标志物,可用于随访和有希望的测试,以预测早期的治疗反应和生存,并改变治疗方式。
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引用次数: 0
Health behavior and health needs of first-year medical and health sciences students 医学与健康科学一年级学生的健康行为与健康需求
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244398
Kamer Gur, Saime Erol, E. Gunes, Serap Çi̇fçi̇li̇, Burcu K CALIK, A. Ozer, I. Demirbuken, M. Polat, Çiğdem Apaydın Kaya
Objective: The aim of this study is to evaluate the health behavior and health needs of medical and health sciences students in order to identify areas that need intervention. Materials and Methods: This descriptive study was conducted with 770 first-year university students. The data were collected with a sociodemographic questionnaire, the Youth Risk Behavior Survey and the Eating Attitudes Test. Body mass index was calculated. Results: Although, only 12.7% of the students were overweight or obese, 25.6% of the students perceived themselves to be overweight or obese. The students said that in the last week, 20.9% had breakfast 1 or 3 times, 5.7% ate no fruits at all, and 11.6% ate no vegetables at all. 48.1% of the students did not engage in any physical activity, and 83.2% spent more than 2 hours inactively in front of a screen. It was observed that 22.3% were current smokers. A propensity for eating behaviors disorder was found in 9.0%. Drinking energyboosting sports drinks 1-6 times in the last week (β: 3.286), smoking (β: 1.875) and eating few vegetable dishes in the last week (β: 0.484) were identified as factors that could be associated with a “tendency for eating behavior disorder.” Conclusion: We can conclude that nutritional issues, negative body weight perception, use of tobacco, and sedentary lifestyle are the main intervention and counselling areas for our study group.
目的:本研究旨在评估医学与健康科学专业学生的健康行为和健康需求,以确定需要干预的领域。材料与方法:本研究对770名一年级大学生进行了描述性研究。这些数据是通过社会人口学问卷、青少年风险行为调查和饮食态度测试收集的。计算体重指数。结果:尽管只有12.7%的学生超重或肥胖,但25.6%的学生认为自己超重或肥胖。学生们表示,在上周,20.9%的人早餐吃了1到3次,5.7%的人根本不吃水果,11.6%的人完全不吃蔬菜。48.1%的学生没有参加任何体育活动,83.2%的学生在屏幕前不活跃地呆了2个小时以上。据观察,22.3%的人是目前的吸烟者。9.0%的人有饮食行为障碍的倾向。上周喝1-6次富含能量的运动饮料(β:3.286)、吸烟(β:1.875)和上周少吃蔬菜(β:0.484)被确定为可能与“饮食行为障碍倾向”相关的因素。结论:我们可以得出结论,消极的体重感知、吸烟和久坐不动的生活方式是我们研究小组的主要干预和咨询领域。
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引用次数: 0
Being a mother as a healthcare professional in the COVID-19 pandemic: A qualitative study 在新冠肺炎大流行中作为医疗保健专业人员的母亲:一项定性研究
IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-31 DOI: 10.5472/marumj.1244379
Nesibe Gunay Molu, Sadiye Sert, Neslihan Durmuşoğlu Saltali
Objective: The aim of this research was to determine the changes in relationships between healthcare professional mothers and theirpreschool-aged children during the coronavirus disease 2019 (COVID-19) pandemic. In addition, the second objective of this studywas to propose a new phenomenon that explains “being a mother as a healthcare professional” during the COVID-19 pandemic.Materials and Methods: The participants of the research were 16 healthcare professional mothers (8 doctors and 8 nurses) who hadworked in intensive care units during the COVID-19 pandemic and had a preschool-aged child. The research was conducted inaccordance with the phenomenological approach, one of the qualitative research designs. The research data were obtained throughface-to-face interviews between the researchers and the participants using half-structured interview forms prepared by the researchers.Colaizzi’s 7-step method was used for evaluation of the data.Results: According to the research findings, the phenomenon of “being a mother as a healthcare professional” was gathered underfour main themes: emotional reactions, new normal in life, difficulties that pandemic brought in life and coping strategies with thesedifficulties.Conclusion: The findings showed that the COVID-19 pandemic caused many changes in the lives of healthcare professional mothersand their children; these mothers and children built some emotional reactions, and they developed various strategies to overcomethese emotional reactions.
目的:本研究的目的是确定在2019冠状病毒病(COVID-19)大流行期间医护专业母亲与其学龄前儿童之间关系的变化。此外,本研究的第二个目标是提出一种新现象,解释在COVID-19大流行期间“作为医疗保健专业人员的母亲”。材料与方法:研究对象为16名在COVID-19大流行期间在重症监护病房工作并育有学龄前儿童的医疗保健专业母亲(8名医生和8名护士)。本研究是按照质性研究设计之一的现象学方法进行的。研究数据通过研究者与参与者面对面访谈的方式获得,访谈采用研究者准备的半结构化访谈表格。采用Colaizzi的7步法对数据进行评价。结果:根据研究结果,将“作为保健专业人员的母亲”现象归纳为四个主题:情绪反应、生活新常态、流行病给生活带来的困难以及应对这些困难的策略。结论:新冠肺炎大流行给医护人员母亲及其子女的生活带来了诸多变化;这些母亲和孩子建立了一些情绪反应,他们想出了各种策略来克服这些情绪反应。
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引用次数: 0
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Marmara Medical Journal
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