Emre KUDU, Sena Özge ASLAN, Dilan GENÇ, Oğuzhan DEMİR, Arzu DENİZBAŞI
Ectopic pregnancy is the implantation of the developing embryo outside the uterine cavity. It usually occurs in the fallopian tubes. One
of the critical complications of ectopic pregnancy is rupture. The most common symptoms of ectopic pregnancy rupture are vaginal
bleeding and abdominal pain. In atypical presentations, the diagnosis is based on suspicion. Herein, we presented a case of ruptured
ectopic pregnancy with an atypical presentation. The diagnosis of ruptured ectopic pregnancy should be considered when women with
childbearing potential apply to the emergency department.
{"title":"Successful diagnosis of a ruptured ectopic pregnancy: A woman without abdominal pain and vaginal bleeding","authors":"Emre KUDU, Sena Özge ASLAN, Dilan GENÇ, Oğuzhan DEMİR, Arzu DENİZBAŞI","doi":"10.5472/marumj.1379879","DOIUrl":"https://doi.org/10.5472/marumj.1379879","url":null,"abstract":"Ectopic pregnancy is the implantation of the developing embryo outside the uterine cavity. It usually occurs in the fallopian tubes. One
 of the critical complications of ectopic pregnancy is rupture. The most common symptoms of ectopic pregnancy rupture are vaginal
 bleeding and abdominal pain. In atypical presentations, the diagnosis is based on suspicion. Herein, we presented a case of ruptured
 ectopic pregnancy with an atypical presentation. The diagnosis of ruptured ectopic pregnancy should be considered when women with
 childbearing potential apply to the emergency department.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase
chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19).
Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both
chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was
calculated and data were matched with PCR results.
Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR
results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%,
265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%)
patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group
Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be
the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test
results, ensuring infection prevention and control measures can be preserved.
目的:探讨胸部计算机断层扫描(CT)与逆转录聚合酶(rase)的诊断价值;链式反应(RT-PCR)在门诊疑似冠状病毒病2019 (COVID-19)中的应用。
患者和方法:在2020年3月至6月期间，共有812例临床疑似COVID-19患者接受了
回顾性纳入门诊入院时的胸部CT和初始单次RT-PCR。CT严重程度评分(CT- ss)为
计算和数据与PCR结果吻合。
结果:812例患者中，54%(439/812)的RT-PCR结果呈阳性，47%(425/812)的胸部CT扫描呈阳性。用rt - pcr # x0D;结果作为参考，胸部CT诊断COVID-19感染的敏感性、特异性、准确性为60%，(95% CI 56 ~ 65%，
265/439例患者)，57% (95% CI 52-62%， 213/373)， 59% (95% CI 55-62%， 478/812)。387 (47%)
未见CT表现，轻度380/812例(46.8%)，中度45/812例(5.5%)，重度组无患者;结论:胸部CT对门诊患者COVID-19的诊断敏感性不高。我们建议RT-PCR应该
主诊断工具。如果临床怀疑强烈且反复出现RT-PCR阴性，可考虑胸部CT检查
结果:确保感染防控措施得以保留。
{"title":"Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19","authors":"Elif TÜKENMEZ TİGEN, Buket ERTURK SENGEL, Canan CİMSİT, Hande PERK GURUN, Çiğdem APAYDIN KAYA, Volkan KORTEN","doi":"10.5472/marumj.1379916","DOIUrl":"https://doi.org/10.5472/marumj.1379916","url":null,"abstract":"Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase
 chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19).
 Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both
 chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was
 calculated and data were matched with PCR results.
 Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR
 results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%,
 265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%)
 patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group
 Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be
 the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test
 results, ensuring infection prevention and control measures can be preserved.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatih BESIROGLU, Murat SUNBUL, Beste OZBEN, Ilker YAGCI, Jeyhun MAMMADOV, Nurten SAYAR, Altug CINCIN, Kursat TIGEN, Osman YESILDAG, Yelda BASARAN
Objective: The aim of our study is to investigate the impact of cardiac rehabilitation on left ventricular (LV) diastolic function in acute
coronary syndrome (ACS) patients.
Patients and Methods: Patients were selected consecutively among ACS patients who underwent primary percutaneous intervention
and were found eligible for cardiac rehabilitation program from May 2014 to May 2015. Forty-four patients were included in cardiac
rehabilitation group and recruited to 30 sessions of Phase-3 cardiac rehabilitation program six weeks after discharge. Twenty
consecutive patients were included as control group. LV diastolic functions were assessed by resting and stress echocardiography.
Results: There were not any significant differences in characteristics between the groups. Resting and stress E velocities and resting
lateral e’ velocity significantly increased after rehabilitation program. Left atrial volume index, resting and stress A velocities and
average E/e’ ratios were significantly lower while stress lateral e’ velocity was significantly higher in rehabilitation group after program
compared to controls. The number of patients with diastolic dysfunction decreased after rehabilitation program. Final resting and
stress echocardiography revealed significantly lower frequency of diastolic dysfunction in rehabilitation group.
Conclusion: Cardiac rehabilitation improves diastolic functions in ACS patients, which may be detected by stress echocardiography.
{"title":"The effect of cardiac rehabilitation on left ventricular diastolic functions assessed by exercise stress echocardiography in patients with acute coronary syndrome","authors":"Fatih BESIROGLU, Murat SUNBUL, Beste OZBEN, Ilker YAGCI, Jeyhun MAMMADOV, Nurten SAYAR, Altug CINCIN, Kursat TIGEN, Osman YESILDAG, Yelda BASARAN","doi":"10.5472/marumj.1378522","DOIUrl":"https://doi.org/10.5472/marumj.1378522","url":null,"abstract":"Objective: The aim of our study is to investigate the impact of cardiac rehabilitation on left ventricular (LV) diastolic function in acute
 coronary syndrome (ACS) patients.
 Patients and Methods: Patients were selected consecutively among ACS patients who underwent primary percutaneous intervention
 and were found eligible for cardiac rehabilitation program from May 2014 to May 2015. Forty-four patients were included in cardiac
 rehabilitation group and recruited to 30 sessions of Phase-3 cardiac rehabilitation program six weeks after discharge. Twenty
 consecutive patients were included as control group. LV diastolic functions were assessed by resting and stress echocardiography.
 Results: There were not any significant differences in characteristics between the groups. Resting and stress E velocities and resting
 lateral e’ velocity significantly increased after rehabilitation program. Left atrial volume index, resting and stress A velocities and
 average E/e’ ratios were significantly lower while stress lateral e’ velocity was significantly higher in rehabilitation group after program
 compared to controls. The number of patients with diastolic dysfunction decreased after rehabilitation program. Final resting and
 stress echocardiography revealed significantly lower frequency of diastolic dysfunction in rehabilitation group.
 Conclusion: Cardiac rehabilitation improves diastolic functions in ACS patients, which may be detected by stress echocardiography.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Our study examined the relationship between purpose of social media use, perceived social support, and cyberbullying among adolescent girls with or without major depressive disorder (MDD). Patients and Methods: Fifty-two adolescent girls aged 13-18 years with a diagnosis of MDD were recruited. The control group consisted of 51 adolescents who were matched for age and gender. The adolescents completed a sociodemographic form, the Childhood Depression Inventory (CDI), the Social Media Attitude Scale (SMAS), the Cyberbullying Scale (CBS), and the Social Support Appraisal Scale for Children (SSAS). Results: Social media use was significantly higher among adolescent girls with MDD (P
{"title":"Social media use in adolescent girls with depression: The relationship between social media use purposes, lack of social support, and cyber victimization","authors":"Muhsine Göksu, Ayşe Rodopman Arman, Ümmügülsüm Gündoğdu, Funda Gümüştaş","doi":"10.5472/marumj.1379988","DOIUrl":"https://doi.org/10.5472/marumj.1379988","url":null,"abstract":"Objective: Our study examined the relationship between purpose of social media use, perceived social support, and cyberbullying among adolescent girls with or without major depressive disorder (MDD). Patients and Methods: Fifty-two adolescent girls aged 13-18 years with a diagnosis of MDD were recruited. The control group consisted of 51 adolescents who were matched for age and gender. The adolescents completed a sociodemographic form, the Childhood Depression Inventory (CDI), the Social Media Attitude Scale (SMAS), the Cyberbullying Scale (CBS), and the Social Support Appraisal Scale for Children (SSAS). Results: Social media use was significantly higher among adolescent girls with MDD (P","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139358651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Preimplantation-factor (PIF) is a new peptide with many potential functions. We aimed to compare the maternal serum PIF levels among early-onset preeclamptic patients with the healthy controls at the same gestational age. Patients and Methods: Thirty-nine early-onset preeclamptic (< 34 gestational weeks) patients and 45 healthy expecting women have been added to our study. Patients with or suspicion of any chronical maternal disease, gestational diabetes, twin pregnancies, fetal or placental anomalies or any other obstetric complications have been excluded. Competitive enzyme-linked immunosorbent assay (ELISA) (Elabscience Biotechnology Co., Texas, USA) has been used to analyze the PIF levels in the collected samples. Gestational age, maternal age, gravida, parity, fetal growth, body mass index (BMI), maternal weight and height, plasma PIF levels have been collected/measured and analyzed in both groups. Results: The primary outcome of our study –the Preimplantation Factor- was significantly higher in study group than the healthy controls (100.36 ± 41.92 vs. 83.14 ± 51.27 p=0.016). Conclusions: We have found the PF levels statistically higher in the study group. PIF levels might have a role in the progression and pathogenesis of the preeclamptic patients. Further studies with larger groups have to be planned and performed to resolve the real relation between PIF and preeclampsia.
{"title":"Endogenous maternal serum preimplantation factor levels in earlyonset preeclamptic pregnancies","authors":"Muhammet Atay OZTEN, Ece KARACA","doi":"10.5472/marumj.1229910","DOIUrl":"https://doi.org/10.5472/marumj.1229910","url":null,"abstract":"Objective: Preimplantation-factor (PIF) is a new peptide with many potential functions. We aimed to compare the maternal serum PIF levels among early-onset preeclamptic patients with the healthy controls at the same gestational age. Patients and Methods: Thirty-nine early-onset preeclamptic (&lt; 34 gestational weeks) patients and 45 healthy expecting women have been added to our study. Patients with or suspicion of any chronical maternal disease, gestational diabetes, twin pregnancies, fetal or placental anomalies or any other obstetric complications have been excluded. Competitive enzyme-linked immunosorbent assay (ELISA) (Elabscience Biotechnology Co., Texas, USA) has been used to analyze the PIF levels in the collected samples. Gestational age, maternal age, gravida, parity, fetal growth, body mass index (BMI), maternal weight and height, plasma PIF levels have been collected/measured and analyzed in both groups. Results: The primary outcome of our study –the Preimplantation Factor- was significantly higher in study group than the healthy controls (100.36 ± 41.92 vs. 83.14 ± 51.27 p=0.016). Conclusions: We have found the PF levels statistically higher in the study group. PIF levels might have a role in the progression and pathogenesis of the preeclamptic patients. Further studies with larger groups have to be planned and performed to resolve the real relation between PIF and preeclampsia.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135195820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Gestational diabetes mellitus is characterized by increased blood sugar that first appears during pregnancy. Multiple articles have described a relationship between hypothyroidism/subclinical hypothyroidism (SCH) and a rise in the risk of concomitant pregnancy complications, including gestational diabetes mellitus (GDM), but the effect of SCH on pregnancy is uncertain in the literature. We clarified the contribution of SCH to GDM development. Patients and Methods: We conducted a retrospective study. From the patient records, the first 250 pregnant women who applied to our hospital for screening at 20-24 weeks and had glucose tolerance tests were included in our study. Retrospectively, all these pregnant women’s first-trimester thyroid-stimulating hormone (TSH) levels were recorded. We created two groups according to the oral glucose tolerance test (OGTT) results: a case group diagnosed with GDM and a control group with average blood glucose. Their first-trimester TSH levels were compared between the two groups and defined whether they had euthyroid, subclinical hypothyroidism (TSH=2.5- 5.5mIU/L) or overt hypothyroidism (TSH >5.5). Results: We diagnosed 37 of 191 patients (19.4%) with GDM. When we checked the case and control groups, the mean TSH of the GDM group was 1.8 mIU/L, and the control group was 1.7 mIU/L, but the difference was not statistically significant (p=0.121). 24.32% (n=9) of 37 pregnant women with GDM were diagnosed with subclinical hypothyroidism/hypothyroidism; this rate was as low as 14.93% (n=28) in the non-GDM group, but no statistical difference was found (p=0.21). Conclusion: It can be predicted that other accompanying factors may be the primary determinant in the development of GDM rather than subclinical hypothyroidism. Risk scales that include the first trimester TSH level should be established for the development of GDM.
{"title":"Is subclinical hypothyroidism a risk factor for gestational diabetes mellitus?","authors":"H. Şen Selim, M. Sengul","doi":"10.5472/marumj.1302525","DOIUrl":"https://doi.org/10.5472/marumj.1302525","url":null,"abstract":"Objective: Gestational diabetes mellitus is characterized by increased blood sugar that first appears during pregnancy. Multiple articles \u0000have described a relationship between hypothyroidism/subclinical hypothyroidism (SCH) and a rise in the risk of concomitant \u0000pregnancy complications, including gestational diabetes mellitus (GDM), but the effect of SCH on pregnancy is uncertain in the \u0000literature. We clarified the contribution of SCH to GDM development. \u0000Patients and Methods: We conducted a retrospective study. From the patient records, the first 250 pregnant women who applied to our \u0000hospital for screening at 20-24 weeks and had glucose tolerance tests were included in our study. Retrospectively, all these pregnant \u0000women’s first-trimester thyroid-stimulating hormone (TSH) levels were recorded. We created two groups according to the oral glucose \u0000tolerance test (OGTT) results: a case group diagnosed with GDM and a control group with average blood glucose. Their first-trimester \u0000TSH levels were compared between the two groups and defined whether they had euthyroid, subclinical hypothyroidism (TSH=2.5- \u00005.5mIU/L) or overt hypothyroidism (TSH >5.5). \u0000Results: We diagnosed 37 of 191 patients (19.4%) with GDM. When we checked the case and control groups, the mean TSH of the \u0000GDM group was 1.8 mIU/L, and the control group was 1.7 mIU/L, but the difference was not statistically significant (p=0.121). 24.32% \u0000(n=9) of 37 pregnant women with GDM were diagnosed with subclinical hypothyroidism/hypothyroidism; this rate was as low as \u000014.93% (n=28) in the non-GDM group, but no statistical difference was found (p=0.21). \u0000Conclusion: It can be predicted that other accompanying factors may be the primary determinant in the development of GDM rather \u0000than subclinical hypothyroidism. Risk scales that include the first trimester TSH level should be established for the development of \u0000GDM.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48781550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. Patients and Methods: This study analyzed 1.5T magnetic resonance (MR) images of 86 patients retrospectively. The participants were divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle (VFA) T1 mapping technique was used to estimate liver T1 relaxation time. T1 mapping sequence, T2* mapping sequence, and image analysis were performed. The liver size, the spleen size, the liver T1 relaxation time, and the liver T2* relaxation time were recorded. Results: The T1 relaxation time was 758.4 ± 121.1 ms in the chronic hepatitis group and 600.2 ± 67 ms in the control group. The T1 relaxation time of the patient group was significantly higher than that of the control group (p
{"title":"T1 relaxation time in the evaluation of liver fibrosis; with native MR relaxometry","authors":"Firathan Sarialtin, H. Yiğit, E. Ergun, P. Koşar","doi":"10.5472/marumj.1302518","DOIUrl":"https://doi.org/10.5472/marumj.1302518","url":null,"abstract":"Objective: Non-invasive methods have been investigated as an alternative to biopsy in assessing liver fibrosis. This study aimed to \u0000evaluate the relationship between liver T1 relaxation time and liver fibrosis as a non-invasive alternative method. \u0000Patients and Methods: This study analyzed 1.5T magnetic resonance (MR) images of 86 patients retrospectively. The participants were \u0000divided into two groups: patients with chronic hepatitis and the control group. Native variable flip angle (VFA) T1 mapping technique \u0000was used to estimate liver T1 relaxation time. T1 mapping sequence, T2* mapping sequence, and image analysis were performed. The \u0000liver size, the spleen size, the liver T1 relaxation time, and the liver T2* relaxation time were recorded. \u0000Results: The T1 relaxation time was 758.4 ± 121.1 ms in the chronic hepatitis group and 600.2 ± 67 ms in the control group. The T1 \u0000relaxation time of the patient group was significantly higher than that of the control group (p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49367206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to evaluate the blood pressure and heart rates of the patients treated with aripiprazole once-monthly, paliperidone 1-month, and paliperidone 3-month long-acting injections. Patients and Methods: This study was a non-invasive observational study. Subjects using the same long-acting injection preparation for at least four months without skipped injections were assigned to 3 groups according to their treatments. They were screened starting from routine injection day and monthly for four months. Heart rate, systolic blood pressure, and diastolic blood pressure were recorded for each subject. Results: Systolic and diastolic blood pressure among the three treatment groups demonstrated no statıstıcal significance. The heart rate of the paliperidone 3-month group was significantly higher than the aripiprazole once-monthly group. However, the mean heart rate was within the physiological limits. Thus, a clinical significance can hardly be attributed. Conclusion: Aripiprazole once-monthly, paliperidone 1-month, and paliperidone 3- month long-acting injections are non-inferior regarding heart rate, systolic and diastolic blood pressure during the maintenance treatment.
{"title":"Blood pressure and heart rate in aripiprazole once – monthly and paliperidone 1 and 3-month long-acting preparations","authors":"G. Sarıdoğan, M. Goren","doi":"10.5472/marumj.1302445","DOIUrl":"https://doi.org/10.5472/marumj.1302445","url":null,"abstract":"Objective: This study aims to evaluate the blood pressure and heart rates of the patients treated with aripiprazole once-monthly, \u0000paliperidone 1-month, and paliperidone 3-month long-acting injections. \u0000Patients and Methods: This study was a non-invasive observational study. Subjects using the same long-acting injection preparation \u0000for at least four months without skipped injections were assigned to 3 groups according to their treatments. They were screened \u0000starting from routine injection day and monthly for four months. Heart rate, systolic blood pressure, and diastolic blood pressure were \u0000recorded for each subject. \u0000Results: Systolic and diastolic blood pressure among the three treatment groups demonstrated no statıstıcal significance. The heart rate \u0000of the paliperidone 3-month group was significantly higher than the aripiprazole once-monthly group. However, the mean heart rate \u0000was within the physiological limits. Thus, a clinical significance can hardly be attributed. \u0000Conclusion: Aripiprazole once-monthly, paliperidone 1-month, and paliperidone 3- month long-acting injections are non-inferior \u0000regarding heart rate, systolic and diastolic blood pressure during the maintenance treatment.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42592402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. S. Koca, Y. Çelik, H. Keskin, Pinar YALCIN BALCIK
Objective: As healthcare has become increasingly patient-centered, outcomes such as disease-specific quality of life (QoL) have become increasingly important. This study aimed to determine the factors affecting the QoL of postpartum women and which factors make a difference and affect the QoL. Patients and Methods: The Euro QoL 5 Dimension 5 Level (EQ 5D-5L) scale was used to measure the health-related QoL of postpartum women. A total of 175 postpartum mothers participated in this study. Results: The QoL of women differed in age, delivery type, venous thromboembolism risk factors, parity, gravida, number of live births, and use of anticoagulant medication. According to multiple regression analyses, the “age” variable had a significant effect on the QoL. However, the variables of education, social security, employment status, and monthly income of the family were not significant determinants of QoL. Also, the “number of live births” variable did not significantly affect the QoL, other obstetric and clinical variables had a significant effect on the QoL. The gravida increased the QoL but the number of miscarriages and the venous thromboembolism risk score decreased the QoL. Conclusions: This study shows that, the QoL of women varies according to obstetric, socio-demographic, and clinical factors, and “age, gravida, the number of abortions and the venous thromboembolism risk score” variables have a significant effect on the QoL.
{"title":"The factors affecting the QoL among women during the postpartum period","authors":"G. S. Koca, Y. Çelik, H. Keskin, Pinar YALCIN BALCIK","doi":"10.5472/marumj.1302417","DOIUrl":"https://doi.org/10.5472/marumj.1302417","url":null,"abstract":"Objective: As healthcare has become increasingly patient-centered, outcomes such as disease-specific quality of life (QoL) have become \u0000increasingly important. This study aimed to determine the factors affecting the QoL of postpartum women and which factors make a \u0000difference and affect the QoL. \u0000Patients and Methods: The Euro QoL 5 Dimension 5 Level (EQ 5D-5L) scale was used to measure the health-related QoL of postpartum \u0000women. A total of 175 postpartum mothers participated in this study. \u0000Results: The QoL of women differed in age, delivery type, venous thromboembolism risk factors, parity, gravida, number of live \u0000births, and use of anticoagulant medication. According to multiple regression analyses, the “age” variable had a significant effect \u0000on the QoL. However, the variables of education, social security, employment status, and monthly income of the family were not \u0000significant determinants of QoL. Also, the “number of live births” variable did not significantly affect the QoL, other obstetric and \u0000clinical variables had a significant effect on the QoL. The gravida increased the QoL but the number of miscarriages and the venous \u0000thromboembolism risk score decreased the QoL. \u0000Conclusions: This study shows that, the QoL of women varies according to obstetric, socio-demographic, and clinical factors, and “age, \u0000gravida, the number of abortions and the venous thromboembolism risk score” variables have a significant effect on the QoL.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45928541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Mercanci, C. Ilgın, Ş. Olgun Yıldızeli, D. Kocakaya, B. Balcan, Buket Erturk Sengel, S. Karakurt, E. Eryuksel
Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 75(33.2%) patients, according to the staging of Siddiqi et al., 67 (29.7%) patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25% (95%CI 74.8%-89.71%). When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was 94.15%, correctly classified rate 88.5%, positive likelihood ratio as (LR):5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.
{"title":"Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients","authors":"Z. Mercanci, C. Ilgın, Ş. Olgun Yıldızeli, D. Kocakaya, B. Balcan, Buket Erturk Sengel, S. Karakurt, E. Eryuksel","doi":"10.5472/marumj.1302440","DOIUrl":"https://doi.org/10.5472/marumj.1302440","url":null,"abstract":"Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been \u0000reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to \u0000determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. \u0000Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were \u0000included in the study. \u0000Results: The study included 226 patients. According to the World Health Organization staging, 75(33.2%) patients, according to the \u0000staging of Siddiqi et al., 67 (29.7%) patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer \u0000was found to be 82.25% (95%CI 74.8%-89.71%). When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was \u000094.15%, correctly classified rate 88.5%, positive likelihood ratio as (LR):5.69, negative LR:0.71. \u0000Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality \u0000in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the \u0000Turkish Caucasian ethnic group.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47632853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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