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A Review: Drug Discovery Methods Based on Artificial Intelligence 综述:基于人工智能的药物发现方法
Jinhao Chen
The discovery of drugs is recognized as a lengthy, highly costly, and extremely complex process. For example, some traditional drug discovery methods consist of millions of trials to get a druggable compound to the market. Drug discovery based on artificial intelligence can be a prompt, low-cost, and effective way to streamline drug discovery. Although some works have been proposed to use artificial intelligence tools for drug discovery, few people summarize these advances in a systematic way. In this paper, we propose an organized and comprehensive review that outlines a broad range of appliances of artificial intelligence in drug discovery including harnessing virtual screening and molecular docking techniques, utilizing pathway networks for repurposing existing drugs, lead identification, biomarker research, identification of the target, diverse variety of artificial intelligence and their comparison, etc. In addition, we shed light on predicted limitations and challenges in drug discovery based on artificial intelligence, as well as sketch the strategies to harness its potential for upcoming drug design endeavors.
药物研发被认为是一个漫长、高成本和极其复杂的过程。例如,一些传统的药物发现方法需要进行数百万次试验,才能将一种可成药的化合物推向市场。基于人工智能的药物发现是一种快速、低成本、有效的简化药物发现的方法。虽然已经有一些作品提出将人工智能工具用于药物发现,但很少有人对这些进展进行系统的总结。在本文中,我们提出了一篇有条理的综合综述,概述了人工智能在药物发现中的广泛应用,包括利用虚拟筛选和分子对接技术、利用通路网络对现有药物进行再利用、先导物鉴定、生物标记物研究、靶点鉴定、各种人工智能及其比较等。此外,我们还揭示了基于人工智能的药物发现所面临的限制和挑战,并勾画了在即将开展的药物设计工作中利用人工智能潜力的策略。
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引用次数: 0
ARIMA Model-Based Research on Stock Price Prediction 基于 ARIMA 模型的股价预测研究
Dong Liang
Securities trading has always been a high-risk, high-return domain. Investors seek high returns while endeavoring to minimize risks as much as possible. Therefore, stock price prediction has become a popular and immensely valuable research topic. This paper will use the ARMA model to forecast stock prices. Firstly, an analysis was conducted on selected stock, determining that the price sequence exhibits no seasonal effects but does display volatility effects. The trend is essentially linear, and the relationship between volatility effects and trends fits an additive model. Based on this, preprocessing was conducted by taking the three-day moving average sequence of the series to eliminate the volatility effects, yielding a clean sequence trend. Then, the trend was differenced once to obtain a stationary sequence. Subsequently, the appropriate ARIMA model order was determined by the (partial) autocorrelation plot of this stationary sequence, and the model was fitted to the stock for prediction, yielding satisfactory results. This indicates that the model can accurately forecast long-term trends, but the filtering of volatility effects prevents the prediction results from sensitively reflecting short-term fluctuations.
证券交易一直是一个高风险、高回报的领域。投资者在追求高回报的同时,也在尽可能地降低风险。因此,股票价格预测已成为一个热门且极具价值的研究课题。本文将使用 ARMA 模型来预测股票价格。首先,对选定的股票进行分析,确定价格序列没有季节效应,但有波动效应。趋势基本上是线性的,波动效应与趋势之间的关系符合加法模型。在此基础上,通过对序列的三天移动平均序列进行预处理,以消除波动效应,从而得到清晰的序列趋势。然后,对趋势进行一次差分,以获得静态序列。随后,根据该静态序列的(部分)自相关图确定适当的 ARIMA 模型阶数,并将该模型拟合到股票上进行预测,结果令人满意。这表明该模型可以准确预测长期趋势,但由于过滤了波动效应,预测结果无法灵敏反映短期波动。
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引用次数: 0
Real world ambulatory boundary effect within MTL oscillation during movement in human brains 人脑运动过程中 MTL 振荡的真实世界流动边界效应
Siwei Wu
Through daily life, complex tasks require the neural encoding of spatial location for oneself and others. Previous research studies in rodents have shown that rodents have neural representations of themselves in addition to other rodents. ( Ovchinnikov, 2010) However, there is still a need to understand how the human brain processes spatial location for itself and others. Furthermore, it is important to research which parts of human cognition can affect location encoding mechanisms. The current study uses existing data to determine the correlation between environmental boundaries and human brain activity. Using spatial observation and navigation tasks, the study investigated whether a physical boundary can affect neural encoding using implanted electrodes, representing the participants’ location and others’ location while in a closed environment. Results showed that representations were strengthened when the encoding of location had a greater behavioral significance and was contingent upon the momentary cognitive state of the individual.Together, these findings support the existence of a shared encoding mechanism within the human brain that signifies the whereabouts of both individuals in communal settings. Moreover, they illuminate novel insights into the neural processes that govern spatial navigation and the perception of others in practical situations.
在日常生活中,复杂的任务需要对自己和他人的空间位置进行神经编码。以前对啮齿类动物的研究表明,啮齿类动物除了对自己有神经表征外,对其他啮齿类动物也有神经表征。(Ovchinnikov, 2010)然而,我们仍然需要了解人类大脑是如何处理自己和他人的空间位置的。此外,研究人类认知的哪些部分会影响位置编码机制也很重要。目前的研究利用现有数据来确定环境边界与人类大脑活动之间的相关性。该研究利用空间观察和导航任务,通过植入电极调查物理边界是否会影响神经编码。结果表明,当位置编码具有更大的行为意义并取决于个体的瞬间认知状态时,表征会得到加强。这些发现共同支持了人脑中存在一种共享编码机制,它能在公共环境中指示两个人的行踪。此外,这些发现还揭示了在实际情境中支配空间导航和感知他人的神经过程的新见解。
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引用次数: 0
Bi-Directional Optimization of V2G Strategy Based on Multi-Objective Optimization: Balancing Grid Load and Reducing Electric Vehicle Charging Costs 基于多目标优化的 V2G 策略双向优化:平衡电网负荷并降低电动汽车充电成本
Yilin Liu
With the rapid increase in the number of electric vehicles (EVs), vehicle-to-grid (V2G) technology plays a vital role in reducing the burden on the power system. This technology optimizes network load distribution through a two-way charging mechanism and effectively alleviates network load fluctuations. However, potential negative impacts on EV battery life should also be a cause for concern. Furthermore, the technology does not fundamentally change the charging behavior of electric vehicles. Against this background, this study proposes a multi-objective optimization strategy to adapt electricity price policy to network load fluctuations to control charging behavior. This strategy optimizes battery attenuation, charging costs, and network load fluctuations, aiming to alleviate network load fluctuations while completely solving user concerns about charging and battery maintenance costs. Simulation analysis has verified the effectiveness of this model in reducing grid load fluctuations and balancing user costs.
随着电动汽车(EV)数量的快速增长,车联网(V2G)技术在减轻电力系统负担方面发挥着至关重要的作用。该技术通过双向充电机制优化网络负荷分配,有效缓解网络负荷波动。然而,对电动汽车电池寿命的潜在负面影响也应引起关注。此外,该技术并未从根本上改变电动汽车的充电行为。在此背景下,本研究提出了一种多目标优化策略,使电价政策适应网络负荷波动,从而控制充电行为。该策略优化了电池衰减、充电成本和网络负荷波动,旨在缓解网络负荷波动,同时彻底解决用户对充电和电池维护成本的担忧。仿真分析验证了该模型在减少电网负荷波动和平衡用户成本方面的有效性。
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引用次数: 0
Exploration of the Application of UAV Remote Sensing Technology in Engineering Surveying and Mapping 无人机遥感技术在工程测绘中的应用探讨
Suqi Liu
The application of UAV remote sensing technology in engineering surveying and mapping has gradually become widespread due to its high efficiency and accuracy. It cannot only quickly obtain high-definition mapping data to provide accurate and complete information support for engineering design and construction but also make up for the limitations of traditional engineering surveying and mapping and promote the innovation and development of the surveying and mapping field. Therefore, this paper explores the application of UAV remote sensing technology in engineering mapping. The exploration of UAV remote sensing technology is of great practical significance for achieving the goal of high-quality mapping data and high efficiency of the mapping process. Surveying and mapping staff need to have a correct perception and logic of the workflow of UAV remote sensing technology in the field of engineering surveying and mapping, analyze the needs of engineering surveying and mapping step by step, study the use of the technology and specific scenes, and promote the rapid development of technology and innovation, to give full play to the role of remote sensing technology of UAVs, and to arrive at more accurate measurement results.
无人机遥感技术在工程测绘中的应用因其高效率、高精度而逐渐普及。它不仅能快速获取高清测绘数据,为工程设计与施工提供准确、完整的信息支持,还能弥补传统工程测绘的局限性,促进测绘领域的创新与发展。因此,本文探讨了无人机遥感技术在工程测绘中的应用。无人机遥感技术的探索对于实现测绘数据高质量、测绘过程高效率的目标具有重要的现实意义。测绘工作人员需要对无人机遥感技术在工程测绘领域的工作流程有一个正确的认知和逻辑,逐步分析工程测绘的需求,研究技术的使用方法和具体场景,推动技术的快速发展和创新,充分发挥无人机遥感技术的作用,得出更加精准的测量结果。
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引用次数: 0
Progress and Case Study of Satellite Remote Rensing Technology for Carbon Dioxide 二氧化碳卫星遥感技术的进展与案例研究
Jinbo Pu
As the primary cause of global warming, the increase in atmospheric carbon dioxide(CO2) concentration has attracted more and more attention worldwide. With the slogan of “peaking carbon” and “carbon neutrality” in China, the need for quantitative, real-time, and large-scale monitoring of CO2 concentration is becoming more urgent. As an all-weather, high-precision monitoring method for greenhouse gas emissions, satellite remote sensing has great potential in CO2 monitoring. After studying the development and performance of remote sensing satellites for CO2 monitoring, the conclusion drawn by this paper is that the monitoring accuracy of CO2 monitoring sensors is gradually improved with increasing attention to CO2 concentration detection in various countries and that because active remote sensing is not affected by aerosol and solar radiation, the current high-precision CO2 concentration detection has gradually changed from passive remote sensing to a combination of active and passive remote sensing. By reviewing the development process of CO2 monitoring remote sensing satellites and the research and application of CO2 satellite data, this paper finds out the gaps in the current research of CO2 remote sensing satellites. It inspires future scholars who want to carry out research in this field.
作为全球气候变暖的主要原因,大气中二氧化碳(CO2)浓度的增加越来越受到全世界的关注。随着中国提出 "碳封顶 "和 "碳中和 "的口号,对二氧化碳浓度进行定量、实时和大范围监测的需求变得更加迫切。卫星遥感作为一种全天候、高精度的温室气体排放监测方法,在二氧化碳监测中大有可为。在对二氧化碳监测遥感卫星的发展和性能进行研究后,本文得出的结论是:随着各国对二氧化碳浓度检测的日益重视,二氧化碳监测传感器的监测精度逐渐提高;由于主动遥感不受气溶胶和太阳辐射的影响,目前高精度的二氧化碳浓度检测已逐渐从被动遥感转变为主动遥感和被动遥感相结合的方式。本文通过回顾二氧化碳监测遥感卫星的发展历程和二氧化碳卫星数据的研究与应用,发现了目前二氧化碳遥感卫星研究中存在的不足。它对未来想在这一领域开展研究的学者有所启发。
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引用次数: 0
Deepening Intelligent Microgrid Management: A Study on Improving Load Forecasting Accuracy Based on Informer Models 深化智能微电网管理:基于告警模型提高负荷预测精度的研究
Yuke Wang
In the context of the “double carbon” strategy and the rapid development of deep learning, it provides new ideas for load forecasting of intelligent microgrids. In this study, we choose the Informer model based on the Transformer framework, which improves the self-attention mechanism and reduces the computational cost, to improve load accuracy and to achieve intelligent management of the microgrid system by accurately forecasting power load data.
在 "双碳 "战略和深度学习快速发展的背景下,为智能微电网的负荷预测提供了新思路。在本研究中,我们选择了基于 Transformer 框架的 Informer 模型,该模型改进了自我关注机制,降低了计算成本,通过准确预测电力负荷数据,提高负荷精度,实现微电网系统的智能化管理。
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引用次数: 0
Improvement of EfficientNet in medical waste classification 改进医疗废物分类中的 EfficientNet
Xiaomo Wang
In recent years, medical waste has gained attention due to its hazardous nature, complexity, and high cost of manual sorting and management. Therefore, it is crucial to develop classification systems that are accurate and efficient. This study analyzes various deep learning models for medical waste classification, compares their accuracies in image recognition, and provides an in-depth analysis of EfficientNet, a classification model that is well-suited to handle large amounts of waste mixing. EfficientNet’s superior performance can be adapted to numerous potential scenarios in medical waste, and its improved performance is also very promising in the field of medical waste classification. The data demonstrate its significant advantages over other models, indicating broad application prospects and economic benefits.
近年来,医疗废物因其危险性、复杂性以及人工分类和管理的高成本而备受关注。因此,开发准确高效的分类系统至关重要。本研究分析了用于医疗废物分类的各种深度学习模型,比较了它们在图像识别中的准确性,并深入分析了适合处理大量废物混合的分类模型 EfficientNet。EfficientNet 的优越性能可适用于医疗废物中的众多潜在场景,其性能的提升在医疗废物分类领域也大有可为。数据表明,与其他模型相比,EfficientNet 具有显著优势,具有广阔的应用前景和经济效益。
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引用次数: 0
Research on the Influencing Factors of New Energy Cars Prices 新能源汽车价格影响因素研究
Xijun Wang
This article aims to identify those factors that have an impact on new energy vehicle prices. The method of multiple linear regression is used to analyze the significant factors using 100 samples from Kaggle. Based on an assumption, 13 variables that were chosen do correlate with new energy car prices. This paper will analyze these following factors: energy type, engine power, reviews count, seating capacity, fuel tank capacity, body type, rating, no cylinder, max power rp, max power bhp, max power rpm, max power nm, transmission type. This article uses multiple linear regression models to analyze these factors’ influence on new energy vehicles. Overall, new energy vehicle prices can be analyzed by the extent to which these factors affect them. By calculation, it is determined that engine power, no cylinder, and max power bhp will have a significant positive impact on the starting price. Max torque rpm and max torque nm will have a significant negative influence on the starting price.
本文旨在找出对新能源汽车价格有影响的因素。本文采用多元线性回归的方法,利用来自 Kaggle 的 100 个样本对重要因素进行分析。根据假设,选取的 13 个变量确实与新能源汽车价格相关。本文将分析以下因素:能源类型、发动机功率、评论数、座位数、油箱容量、车身类型、等级、无气缸、最大功率 rp、最大功率 bhp、最大功率 rpm、最大功率 nm、变速箱类型。本文采用多元线性回归模型分析这些因素对新能源汽车的影响。总体而言,新能源汽车价格可以通过这些因素的影响程度来分析。通过计算,可以确定发动机功率、无缸数、最大功率 bhp 对起步价有显著的正向影响。最大扭矩 rpm 和最大扭矩 nm 对起步价有明显的负面影响。
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引用次数: 0
Research on Fire Alarm Network for High-rise Buildings Based on Wireless Sensor Networks 基于无线传感器网络的高层建筑火灾报警网络研究
Keyan Wei
This paper presents the design of a fire safety and security network for high-rise buildings based on wireless sensor networks. Utilizing the Zigbee system’s topology and Zigbee technology for wireless sensor network communication, the design enables intercommunication among sensor nodes, forming a multi-network system. This system facilitates the preemptive warning and dissemination of fire-related information, facilitating efficient information transmission. Simulation results affirm the practical effectiveness of this design scheme, underscoring its substantial applicability.
本文介绍了基于无线传感器网络的高层建筑消防安全和安保网络的设计。该设计利用 Zigbee 系统的拓扑结构和无线传感器网络通信的 Zigbee 技术,实现了传感器节点之间的互联互通,形成了一个多网络系统。该系统有利于火灾相关信息的预先警告和传播,提高了信息传输效率。仿真结果肯定了这一设计方案的实际效果,强调了其巨大的适用性。
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引用次数: 0
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Science and Technology of Engineering, Chemistry and Environmental Protection
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