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2010 Biomedical Circuits and Systems Conference (BioCAS)最新文献

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A Quasi-Delay-Insensitive Dual-Rail low-pass filter working in subthreshold region 一种工作在亚阈值区域的准延迟不敏感双轨低通滤波器
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709609
Xiaofei Chang, Y. Lian
In this paper, we present a design of Quasi-Delay-Insensitive Dual-Rail (QDI-DR) asynchronous FIR low-pass filter working in subthreshold region. The filter is implemented in 0.13μm standard CMOS technology and is able to operate with variations of voltages, temperatures and processes. Postlayout simulation shows the design achieves the lowest operating voltage of 170mV with a speed of 2.5kHz. The most energy-efficient point occurs at 250mV with a Power-Delay Product (PDP) of 2.53pJ.
本文设计了一种工作在亚阈值区域的准延迟不敏感双轨(QDI-DR)异步FIR低通滤波器。该滤波器采用0.13μm标准CMOS技术,能够在各种电压、温度和工艺下工作。布局后仿真表明,该设计以2.5kHz的速度实现了170mV的最低工作电压。最节能的点发生在250mV,功率延迟积(PDP)为2.53pJ。
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引用次数: 6
Intimate mixing of analogue and digital signals in a field-programmable mixed-signal array with lopsided logic 模拟和数字信号的密切混合在一个现场可编程混合信号阵列与不平衡的逻辑
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709614
Simeon A. Bamford, M. Giulioni
A field-programmable device has been developed, specialised for neural signal processing and neural modelling applications. The device combines analogue and digital functions, yet unlike other designs for Field-Programmable Mixed-signal Arrays (FPMA), there is no separation between the analogue and digital domains. To allow analogue values to act directly as inputs to digital blocks, all digital circuitry has limited crowbar current. The method of limiting yields lopsided logic thresholds. Two uses of this are demonstrated: a gate which detects digital saturation, and a D-type flip flop which is insensitive to clock slew rate.
一种现场可编程设备已经开发出来,专门用于神经信号处理和神经建模应用。该器件结合了模拟和数字功能,但与现场可编程混合信号阵列(FPMA)的其他设计不同,模拟和数字域之间没有分离。为了允许模拟值直接作为数字模块的输入,所有数字电路都具有有限的撬棍电流。限制的方法产生不平衡的逻辑阈值。演示了它的两种用途:检测数字饱和的门,以及对时钟转换率不敏感的d型触发器。
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引用次数: 2
Design of a low power 100 dB dynamic range integrator for an implantable neural stimulator 植入式神经刺激器低功耗100db动态范围积分器的设计
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709595
N. van Dongen Marijn, A. Wouter
Neural stimulators are expected to play an important role in the future treatment of a wide range of pathologies. A novel system architecture was presented in which the fundamental quantity for functional electrical stimulation, charge, is controlled by measuring the stimulation current [1]. This sets the need for a current integrator to calculate the injected charge. Existing current integrators cannot cope with the specifications for the neural stimulator, including a very high dynamic range, low power consumption and robust enough against process and power supply variations. Therefore a current integrator design is proposed here, which is able to handle a large dynamic range by converting the output to a periodic signal. For this purpose a novel Schmitt trigger design is presented based on a threshold compensated inverter. The implementation shown here has a dynamic range of 100 dB, while achieving a low static power consumption (171nW). This makes it suitable for application in an implantable neural stimulator.
神经刺激器有望在未来广泛的病理治疗中发挥重要作用。提出了一种新的系统架构,其中通过测量刺激电流来控制功能电刺激的基本量——电荷[1]。这就需要一个电流积分器来计算注入电荷。现有的集成商无法满足神经刺激器的规格要求,包括非常高的动态范围、低功耗和对工艺和电源变化的足够鲁棒性。因此,本文提出了一种电流积分器设计,该设计通过将输出转换为周期信号来处理大动态范围。为此,提出了一种基于阈值补偿逆变器的施密特触发器设计。这里展示的实现具有100 dB的动态范围,同时实现低静态功耗(171nW)。这使得它适合应用于植入式神经刺激器。
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引用次数: 7
A high dynamic range low power oscillating pixel for a bio-inspired sensor 一种用于仿生传感器的高动态范围低功率振荡像素
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709620
Massari Nicola, D. Marco, P. Gianmaria, Gottardi Massimo
An ultra-low power biologically inspired pixel is presented in this paper. The pixel has been simulated and designed in 0.35μm CMOS technology and then successfully tested. The core oscillating pixel is a circuit that basically consists of only 5 transistors, potentially showing a reasonable pixel pitch. Thanks to the implemented light to frequency conversion, this pixel topology allows to realize a pulsed-based architecture for a bio-inspired camera. The digital output of the proposed circuit is demonstrated to be linearly proportional to the light impinging on the photodiode potentially performing a dynamic range of more than 120dB and showing a simulated power consumption of 470pJ/MHz per pixel.
提出了一种超低功耗的仿生像素。采用0.35μm CMOS技术对像素进行了仿真设计,并成功进行了测试。核心振荡像素是一个电路,基本上只由5个晶体管组成,潜在地显示出合理的像素间距。由于实现了光到频率的转换,这种像素拓扑结构可以实现基于脉冲的生物启发相机架构。所提出的电路的数字输出被证明与冲击在光电二极管上的光成线性比例,潜在地执行超过120dB的动态范围,并显示出每像素470pJ/MHz的模拟功耗。
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引用次数: 0
A model of stimulus-specific adaptation in neuromorphic a VLSI 神经形态VLSI的刺激特异性适应模型
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709622
R. Mill, Sadique Sheik, Giacomo Indiveri, Susan L. Denham
Stimulus-specific adaptation (SSA) is a phenomenon observed in neural systems which occurs when the spike count elicited in a single neuron by external stimuli decreases with repetitions of the same stimulus, and recovers when a different stimulus is presented. SSA therefore effectively highlights rare events in stimulus sequences, and suppresses responses to repetitive ones. In this paper we present a model of SSA based on synaptic depression and describe its implementation in neuromorphic analog VLSI. The hardware system is evaluated using biologically realistic spike trains with parameters chosen to match those used in physiological experiments. We examine the effect of input parameters upon SSA and show that the trends apparent in the results obtained in silico compare favourably with those observed in biological neurons.
刺激特异性适应(SSA)是在神经系统中观察到的一种现象,当外部刺激在单个神经元中引起的峰值计数随着相同刺激的重复而减少,当出现不同的刺激时恢复。因此,SSA有效地突出了刺激序列中的罕见事件,并抑制了对重复事件的反应。本文提出了一种基于突触抑制的SSA模型,并描述了其在神经形态模拟VLSI中的实现。硬件系统使用生物学上真实的尖峰序列进行评估,其参数选择与生理实验中使用的参数相匹配。我们研究了输入参数对SSA的影响,并表明在计算机中获得的结果中明显的趋势与在生物神经元中观察到的趋势相比较有利。
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引用次数: 1
Fabrication and characterization of a silicone fluorescent oxygen sensor 硅酮荧光氧传感器的制备与表征
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709573
D. Herman Stephen, Jennifer Blain Christen
We discuss the fabrication and characterization details of an optical oxygen sensor for use in a cell culture microsystem. The sensor operates by measuring changes in the fluorescence intensity of (2–2'-bipyridine) dichlororuthenium (II) hexahydrate molecules that are immobilized in a silicone film. The sensor we demonstrate herein is highly linear, reversible, and is compatible with common biomedical sterilization procedures.
我们讨论了用于细胞培养微系统的光学氧传感器的制造和表征细节。传感器通过测量(2-2 '-联吡啶)二氯钌(II)六水分子的荧光强度变化来工作,这些分子固定在硅树脂薄膜中。我们在此演示的传感器是高度线性的,可逆的,并且与常见的生物医学灭菌程序兼容。
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引用次数: 0
Biophysical neural spiking and bursting dynamics in reconfigurable analog VLSI 可重构模拟VLSI的生物物理神经脉冲和爆发动力学
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709602
Theodore Yu, T. Sejnowski, G. Cauwenberghs
We study a range of neural dynamics under variations in biophysical parameters implementing extended Morris-Lecar and Hodgkin-Huxley models in three gating variables. The dynamics are emulated in NeuroDyn, an analog VLSI programmable neural emulation platform with generalized channel kinetics and biophysical membrane dynamics. We present simulation and measurement results and observe consistent agreement over a wide regime of tonic spiking and intrinsic bursting dynamics through the variation of a single conductance parameter governing calcium recovery.
我们研究了生物物理参数变化下的一系列神经动力学,在三个门控变量中实现了扩展的Morris-Lecar和Hodgkin-Huxley模型。在具有广义通道动力学和生物物理膜动力学的模拟VLSI可编程神经仿真平台NeuroDyn中进行了动力学仿真。我们提出了模拟和测量结果,并通过控制钙恢复的单个电导参数的变化,观察到在宽范围内的强直尖峰和固有破裂动力学的一致协议。
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引用次数: 5
A versatile nurse support system using Bluetooth and FeliCa 使用蓝牙和FeliCa的多功能护士支持系统
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709625
M. Shimojima, A. Eguchi, T. Iwanaga, Y. Mizuno, K. Setoguchi, S. Watanabe, Y. Sato, Y. Tanaka
We have developed a versatile nurse support system. The system adapts different wireless technologies to best suite the applications and yet provides a uniform platform to build a user-friendly environment for visiting nurses, gerontological nurses, and at central hospitals. It is designed to ease the daily work of these nurses by eliminating the needs to manually record medical information into multiple systems and enhancing communication between nurses and doctors.
我们开发了一个多功能的护士支持系统。该系统适应不同的无线技术,以最好地配合应用程序,并提供一个统一的平台,为来访护士、老年护士和中心医院的护士建立一个用户友好的环境。它的设计目的是通过消除在多个系统中手动记录医疗信息的需要,加强护士和医生之间的沟通,从而减轻这些护士的日常工作。
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引用次数: 0
Radar cross section of the human heartbeat and respiration 人类心跳和呼吸的雷达横截面
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709569
Oyvind Aardal, S. Hamran, T. Berger, Jan Hammerstad, T. Lande
This paper describes an experimental approach for finding the radar cross section (RCS) of human heartbeats and respiratory movements. A measurement setup, a calibration routine and required processing steps are presented. Using a 2–3GHz Ultra Wideband (UWB) radar, heartbeats and respiration of a human subject were recorded from a distance of 1.14m. Combining the recorded data to measurements with a calibration sphere, the calibrated human heartbeat and respiration RCS was detected.
本文描述了一种寻找人类心跳和呼吸运动的雷达截面(RCS)的实验方法。给出了测量装置、校准程序和所需的处理步骤。使用2-3GHz超宽带(UWB)雷达,从1.14米的距离记录人类受试者的心跳和呼吸。将记录的数据与标定球相结合,检测标定后的人体心跳和呼吸RCS。
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引用次数: 12
An implantable neuroprocessor for multichannel compressive neural recording and on-the-fly spike sorting with wireless telemetry 一种植入式神经处理器,用于多通道压缩神经记录和无线遥测的动态尖峰排序
Pub Date : 2010-11-01 DOI: 10.1109/BIOCAS.2010.5709556
Fei Zhang, M. Aghagolzadeh, K. Oweiss
In this work, a fully implantable and scalable neuroprocessor has been designed to process neural recordings in awake behaving animals. The neuroprocessor operates at 6.4 MHz to process neural signals from 32 microelectrode channels sampled at 25 KHz and transmits only the critical neural information over a 1 Mbps wireless channel in order to meet the stringent hardware and communication constraints imposed on an implantable device. The neuroprocessor can be programmed to compress neural data using a sparse representation of neural signals via lifting discrete wavelet transform (DWT) and/or perform on-the-fly spike sorting on the compressed data stream if followed by a “smart” thresholding mechanism. This unique feature reduces the overall system latency and permit instantaneous decoding of neural signals to take place in real-time. The neuroprocessor therefore uses the limited telemetry bandwidth more efficiently while preserving important information in the neural data, and hence improves the practicality and viability of implantable microelectrode arrays to accelerate their deployment in clinical applications of brain-machine interfaces.
在这项工作中,一个完全可植入和可扩展的神经处理器被设计用来处理清醒行为动物的神经记录。该神经处理器的工作频率为6.4 MHz,处理来自32个采样频率为25 KHz的微电极通道的神经信号,并仅通过1 Mbps的无线通道传输关键神经信息,以满足植入式设备严格的硬件和通信限制。神经处理器可以通过编程,通过提升离散小波变换(DWT)使用神经信号的稀疏表示来压缩神经数据,或者在压缩数据流上执行动态尖峰排序(如果遵循“智能”阈值机制)。这种独特的功能减少了整个系统的延迟,并允许实时进行神经信号的瞬时解码。因此,神经处理器更有效地利用有限的遥测带宽,同时保留神经数据中的重要信息,从而提高可植入微电极阵列的实用性和可行性,加速其在脑机接口临床应用中的部署。
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引用次数: 14
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2010 Biomedical Circuits and Systems Conference (BioCAS)
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