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CORTICAL SPOKES CATARACT 皮质辐条白内障
IF 0.5 Q3 Health Professions Pub Date : 2020-07-16 DOI: 10.46903/gjms/17.03.2077
M. Marwat
A 40 years old man presented with bilateral mild dimness of vision and mild glare. Diffuse and focal illumination on slit lamp biomicroscopy did not reveal any pathology. Retro-illumination on slit lamp showed faint bilateral spokes like cortical lens opacities. Retro-illumination mode on Auto-Ref/Keratometer (HRK 7000A, Huvitz, Anyang-si, Gyeonggi-do, Republic of Korea) prominently revealed these insignificant bilateral spokes like cortical opacities (cataracts). Visual acuity was 6/9 in both eyes. No intervention was advisable and the patient was reassured.
男性,40岁,双侧轻度视力模糊,轻度眩光。裂隙灯生物显微镜下的漫射和聚焦照明未见任何病理变化。裂隙灯反照显示双侧微弱辐条样皮质晶状体混浊。Auto-Ref/Keratometer (HRK 7000A, Huvitz, Anyang-si, gyeongki -do, Republic of Korea)上的反向照明模式突出显示了这些不明显的双侧辐状物,如皮质不透明(白内障)。双眼视力均为6/9。不建议进行干预,并使患者放心。
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引用次数: 0
GJMS Vol 18, No.2, Apr-Jun 2020 GJMS Vol 18, No.2, 2020年4 - 6月
IF 0.5 Q3 Health Professions Pub Date : 2020-06-30 DOI: 10.46903/gjms/18.02
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引用次数: 0
PREVALENCE, DISTRIBUTION AND DETERMINANTS OF DEEP VEIN THROMBOSIS IN ADULT INDOOR STROKE POPULATION OF PESHAWAR DIVISION, PAKISTAN 巴基斯坦白沙瓦地区成年室内卒中人群深静脉血栓形成的患病率、分布和决定因素
IF 0.5 Q3 Health Professions Pub Date : 2020-06-30 DOI: 10.46903/GJMS/18.02.851
Muhammad Bilal, Imran Ullah, Syed Abdur Rehman Shah, Zahidullah Khan, T. Khan, G. Shaheen
Background: Stroke is a devastating public health problem worldwide, considered as the third leading cause of death in developed countries, and the leading cause of disability among adults . Deep vein thrombosis (DVT), including pulmonary embolism (PE) as a sequel, is a serious complication of various medical conditions including stroke. The purpose of this study was to determine frequency of deep vein thrombosis among patients presented with stroke. Materials and methods: This study was descriptive (cross-sectional) study, conducted in the Department of Neurology, Lady Reading Hospital, Peshawar over 6 months. In the study a total of 196 patients were observed. Base line investigations were done and ultrasound was carried out to diagnose deep vein thrombosis. All the laboratory investigations and ultrasound were done by single experience pathologist and sonologist having minimum of five years of experience respectively. Observation and examination was done by neurologist who was not aware about the study and data was recorded in a predesigned proforma. To control confounders and bias in the study results, strict exclusion criteria had been followed. Results: In this study mean age was 63 years with standard deviation ± 28.34. Forty two percent patients were male and 58% patients were female. More over 8% patients had deep vein thrombosis. Conclusion: Our study concludes that the frequency of deep vein thrombosis was 8% among patients presented with stroke.
背景:中风是世界范围内一个破坏性的公共卫生问题,被认为是发达国家第三大死亡原因,也是成年人致残的主要原因。深静脉血栓形成(DVT),包括肺栓塞(PE),是包括中风在内的各种疾病的严重并发症。本研究的目的是确定卒中患者深静脉血栓形成的频率。材料和方法:本研究为描述性(横断面)研究,在白沙瓦雷丁夫人医院神经内科进行,为期6个月。本研究共观察了196例患者。行基线检查及超声诊断深静脉血栓形成。所有的实验室检查和超声分别由具有至少五年经验的单一经验的病理学家和超声专家完成。观察和检查由不知道该研究的神经学家完成,数据以预先设计的形式记录。为了控制研究结果中的混杂因素和偏倚,我们遵循了严格的排除标准。结果:本组患者平均年龄63岁,标准差±28.34。42%的患者为男性,58%的患者为女性。超过8%的患者有深静脉血栓形成。结论:脑卒中患者中深静脉血栓发生率为8%。
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引用次数: 0
LIFE STYLE AND HEALTH EDUCATION 生活方式和健康教育
IF 0.5 Q3 Health Professions Pub Date : 2020-06-25 DOI: 10.46903/gjms/17.03.2079
I. Ahmad
Lifestyle is the interest, behavior, opinion, style of living or world outlook of an individual, group, or culture; a combination of tangible factors like demographics and intangible factors like personal values and preferences.1 Recently researchers have more interest in the relationship between life style and health. Millions of people, following unhealthy lifestyle (or risk-factors), are plagued with morbidity, disability and mortality due to non-communicable, communicable diseases & nutritional disorders. Persons having unhealthy behaviors may be called as ‘at risk groups’.2 Although a healthy lifestyle has consistently been shown to decrease mortality, the population prevalence of healthy living remains low.3 The mental health of an individual can be assessed by his behavior and attitude. Common lifestyle variables influencing health include diet, exercise, sleep, smoking, alcohol consumption, substance abuse, stress management, sexual behavior, internet, recreation, etc.4 Besides, weight management, exposure to the sun, social contact, work life balance, leisure activities, screening for cancer etc. make a healthy life style. Healthy ways of living are developed through processes of socialization with parents, friends, relatives and community. However, not all life style factors are harmful. There are many life styles that promote health. For example, adequate nutrition, exercise, meditation, enough sleep etc.5 Modern or slow epidemics of non-communicable diseases (NCDs) e.g. hypertension (HTN), coronary heart disease (CHD), diabetes mellitus (DM), obesity, cancer etc. have been increasing in incidence compared to the previous century. With the increase in life expectancy, the prevalence of NCDs is on the rise. About 2 billion people are overweight in developed as well as low to middle income countries.6 Comorbidities of obesity include HTN, CHD, DM, stroke, cancers, gallbladder disease, dyslipidaemia, osteoarthritis, gout and sleep apnoea.7 Obesity is not only preventable but treatable with lifestyle modifications to forestall DM.8 Furthermore, several pathways linking obesity and CHD have been described; in particular coronary atherosclerosis, heart failure, and atrial fibrillation.9 In a study by CDC conducted in late 1970s in US, approximately 48% of all premature deaths prior to age 75 years could be traced to one’s lifestyle or health behavior choices, hence focusing on a personal responsibility model whereas another study accounts for about 63% of all deaths.10 Human behavior is a major obstacle to disease control. Changes in human behavior may prevent most of the world's major health problems & premature deaths at low cost. Public health is defined as ‘the health status of a defined group of people and the governmental actions and conditions at the local, state, and national levels to promote healthy behaviors, prevent spread of disease and injuries, protect against environmental hazards & disasters and assure the curative and rehab
生活方式是个人、群体或文化的兴趣、行为、观点、生活方式或世界观;有形因素,如人口统计和无形因素,如个人价值观和偏好的组合最近研究人员对生活方式和健康之间的关系越来越感兴趣。数百万人遵循不健康的生活方式(或风险因素),因非传染性、传染性疾病和营养失调而患病、残疾和死亡。有不健康行为的人可称为“高危人群”虽然健康的生活方式一直被证明可以降低死亡率,但健康生活方式的人口普及率仍然很低一个人的心理健康状况可以通过他的行为和态度来评估。影响健康的常见生活方式变量包括饮食、运动、睡眠、吸烟、饮酒、药物滥用、压力管理、性行为、互联网、娱乐等4此外,体重管理、晒太阳、社交、工作与生活的平衡、休闲活动、癌症筛查等也构成了健康的生活方式。健康的生活方式是通过与父母、朋友、亲戚和社区的社会化过程形成的。然而,并非所有的生活方式因素都是有害的。有许多生活方式可以促进健康。例如,充足的营养、运动、冥想、充足的睡眠等。5现代或缓慢流行的非传染性疾病,如高血压、冠心病、糖尿病、肥胖、癌症等,与上个世纪相比,发病率一直在增加。随着预期寿命的延长,非传染性疾病的患病率呈上升趋势。在发达国家和中低收入国家,约有20亿人超重肥胖的合并症包括HTN、冠心病、糖尿病、中风、癌症、胆囊疾病、血脂异常、骨关节炎、痛风和睡眠呼吸暂停肥胖不仅可以预防,而且可以通过改变生活方式来预防糖尿病。此外,已经描述了几种将肥胖和冠心病联系起来的途径;特别是冠状动脉粥样硬化、心力衰竭和房颤美国疾病控制与预防中心在20世纪70年代末进行的一项研究中,大约48%的75岁之前的过早死亡可以追溯到一个人的生活方式或健康行为选择,因此侧重于个人责任模式,而另一项研究约占所有死亡的63%人类行为是疾病控制的主要障碍。人类行为的改变可以以较低的成本预防世界上大多数重大健康问题和过早死亡。公共卫生被定义为“特定人群的健康状况,以及地方、州和国家各级政府为促进健康行为、防止疾病和伤害的传播、防止环境危害和灾害以及确保治疗和康复卫生服务而采取的行动和条件”。许多公共卫生建议和临床指南都强调健康的生活方式对健康大有裨益通过健康教育改变人口的生活方式,包括卫生组织建议的预防慢性病的三种初级预防方法。在第一方针或初级预防方面,在许多成人健康问题(如肥胖、高血压)尚未出现的国家,通过个人/大众教育,劝阻儿童不要采取有害的生活方式。生活方式是在儿童时期形成的,其目的是防止危险因素的出现。第二种方法或人口(大规模)战略针对全体人口,而不考虑个人的风险水平。社区平均血压/血清胆固醇的小幅下降有助于降低冠心病的患病率。另一方面,第三种方法或高风险策略旨在通过最佳使用临床方法来发现高风险个体并为其提供预防性护理。为了对人口产生影响,上述三种方法都应该实施,因为它们通常是互补的,但结果要在几十年后才能看到,而不是立即看到。4 .除了健康教育外,人民还必须有机会获得预防措施生活方式医学计划通过自我管理技能解决多种风险因素,作为管理非传染性疾病的系统化方法为了预防包括心血管疾病在内的非传染性疾病,所有年龄组、性别、种族和民族都需要促进心肺健康的身体活动仅仅更好地控制行为风险因素就可以预防三分之一的急性残疾和三分之二的慢性残疾。体育锻炼,食用新鲜食品而不是加工食品,限制烹饪/食用盐的使用
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引用次数: 1
MORPHOLOGICAL FINDINGS IN INTRAUTERINE GROWTH RESTRICTION (IUGR) PLACENTAS VERSUS NORMAL PLACENTAS IN PREGNANT WOMEN OF DISTRICT RAWALPINDI, PAKISTAN 巴基斯坦拉瓦尔品第地区孕妇宫内生长受限(IUGR)胎盘与正常胎盘的形态学研究
IF 0.5 Q3 Health Professions Pub Date : 2020-06-10 DOI: 10.46903/gjms/17.03.2021
N. Kiran, N. Aslam, T. Tabassum, Saadia Kanwal, T. Zia
Background: Intrauterine growth restriction (IUGR) is a principal cause of fetal and neonatal morbidity and mortality. The placenta, as a vector for maternal-fetal nutrient and oxygen exchange has major influence on birthweight. The objectives of this study were to compare the placental weight (grams), number of syncytial knots and number of blood vessels in villi of IUGR placentas versus normal placentas. Materials & Methods: This cross-sectional study was carried out at Rai Medical College, Sargodha, Pakistan in collaboration with Zainab Memorial Hospital, Rawalpindi, Pakistan from December 2016 to November 2018. Study group included 45 IUGR placentas and control group included 25 normal placentas. Placental weight in grams, number of syncytial knots and number of blood vessels in villi of placentas were three research variables. These were described by mean, minimum, maximum, range and standard deviation for each group separately and were compared between the two groups through independent-samples t-test. Results: Descriptively the mean placental weight in grams in IUGR group (423.35±64.13g) was lower than control group placentas (535.92±44.57g). The number of syncytial knots in IUGR group placentas (22.04±5.21) was more than control group placentas (13.84±4.41). The number of blood vessels in IUGR placentas was lower than control group placentas. All three null hypothesis for research variables between the two groups were rejected (p=
背景:宫内生长受限(IUGR)是导致胎儿和新生儿发病率和死亡率的主要原因。胎盘作为母婴营养和氧气交换的载体,对出生体重有重要影响。本研究的目的是比较IUGR胎盘与正常胎盘的胎盘重量(克)、合胞结数量和绒毛中血管数量。材料与方法:这项横断面研究于2016年12月至2018年11月在巴基斯坦萨尔戈达Rai医学院与巴基斯坦拉瓦尔品第Zainab纪念医院合作进行。研究组包括45个IUGR胎盘,对照组包括25个正常胎盘。胎盘重量(克)、合胞体结数和胎盘绒毛血管数是三个研究变量。分别用各组的平均值、最小值、最大值、范围和标准差进行描述,并通过独立样本t检验在两组之间进行比较。结果:IUGR组平均胎盘重量(423.35±64.13g)低于对照组(535.92±44.57g),合胞结数(22.04±5.21)高于对照组(13.84±4.41),血管数低于对照组。两组研究变量的三个零假设均被拒绝(p=
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引用次数: 0
NON-COMMUNICABLE DISEASES: A RISING PROBLEM 非传染性疾病:一个日益严重的问题
IF 0.5 Q3 Health Professions Pub Date : 2020-03-31 DOI: 10.46903/gjms/18.01.2131
I. Ahmad
Non-communicable diseases (NCDS) have risen to become a major menace to health worldwide. NCDs include cardiovascular, nervous, renal, mental, chronic lung diseases, permanent results of accidents, arthritis, cancer, diabetes, obesity, senility and blindness etc.
非传染性疾病已上升为对全世界健康的主要威胁。非传染性疾病包括心血管、神经、肾脏、精神、慢性肺部疾病、事故造成的永久性后果、关节炎、癌症、糖尿病、肥胖、衰老和失明等。
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引用次数: 0
DIAGNOSTIC ACCURACY OF FNAC VERSUS OPEN BIOPSY IN DIAGNOSING CARCINOMA BREAST IN PALPABLE ADULT FEMALE BREAST LESIONS IN POPULATION OF KHYBER PAKHTUNKHWA, PAKISTAN FNAC与开放式活检在诊断巴基斯坦开伯尔-普赫图赫瓦地区可触及的成年女性乳腺癌病变中的诊断准确性
IF 0.5 Q3 Health Professions Pub Date : 2020-03-31 DOI: 10.46903/gjms/18.01.2067
M. Khan, H. Shah, K. Javed
Background: FNAC is usually considered as a reliable, easily performed and inexpensive test for diagnosing palpable lesions of breasts with a high degree of accuracy. The objective of this study was to compare the diagnostic accuracy of fine needle aspiration cytology (FNAC) versus open biopsy in carcinoma breast in adult palpable female breast lesions in population of Khyber Pakhtunkhwa, Pakistan. Material and Methods: This cross-sectional study was conducted at Department of Pathology, Lady Reading Hospital, Peshawar, Pakistan from 1st January 2019 to 31st December 2019. Sixty (60) FNAC reports of palpable breast lesions in definitive categories {(C2 (benign) and C5 (malignant)} with respective open biopsy reports were included in the study. Nine (9) FNAC reports of inconclusive categories (C1, C3 & C4) were excluded. Age in years was a single demographic variable. The data for “presence of carcinoma breast” for both the open biopsy and FNAC were placed in two-by-two table. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of FNAC were determined as percentages with confidence intervals at 95% confidence level. Results: The mean age of the sample was 37 ± 17 (17-70, range 53) years. Out of 60 cases on open biopsy, 14 (23.33%) were confirmed as having and 46 (76.67%) as not having carcinoma breast and on FNAC, 12 (20%) were positive and 48 (80%) were negative for carcinoma breast. Two-by-two table showed 12 true positive (TP), 46 true negative (TN), two false negative (FN) and zero false positive (FP) cases. The sensitivity of FNAC was 85.71%, specificity 100%, PPV 100%, NPV 95.83% and accuracy was 96.67%. Conclusion: FNAC is a reliable method in diagnosing carcinoma breast in adult palpable female breast lesions in population of Khyber Pakhtunkhwa, Pakistan.
背景:FNAC通常被认为是诊断乳房可触及病变的一种可靠、容易操作且价格低廉的检测方法,准确率很高。本研究的目的是比较细针吸细胞学(FNAC)与开放式活检在巴基斯坦开伯尔-普赫图赫瓦省成年可触女性乳房病变的诊断准确性。材料和方法:本横断面研究于2019年1月1日至2019年12月31日在巴基斯坦白沙瓦雷丁夫人医院病理科进行。60例FNAC报告可触及的乳腺病变明确分类{(C2(良性)和C5(恶性)},并分别有开放活检报告纳入研究。排除了9例不确定分类(C1、C3和C4)的FNAC报告。年龄是一个单一的人口变量。开放式活检和FNAC的“乳腺癌存在”数据放在2乘2的表格中。FNAC的敏感性、特异性、阳性预测值、阴性预测值和诊断准确性以百分数表示,置信区间为95%。结果:患者平均年龄37±17岁(17 ~ 70岁,范围53岁)。60例开放式活检中确诊乳腺癌14例(23.33%),未确诊乳腺癌46例(76.67%);FNAC阳性12例(20%),阴性48例(80%)。二乘二表显示真阳性(TP) 12例,真阴性(TN) 46例,假阴性(FN) 2例,假阳性(FP) 0例。FNAC的敏感性为85.71%,特异性为100%,PPV为100%,NPV为95.83%,准确率为96.67%。结论:FNAC是诊断巴基斯坦开伯尔-普赫图赫瓦地区成年可触及女性乳腺病变的可靠方法。
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引用次数: 0
OCULAR SURFACE SQUAMOUS CELL NEOPLASIA IN A 25 YEARS MAN FROM D.I.KHAN, PAKISTAN 巴基斯坦迪汗市25岁男性眼表鳞状细胞瘤1例
IF 0.5 Q3 Health Professions Pub Date : 2020-03-31 DOI: 10.46903/gjms/18.01.2108
Muhammad Sharjeel, Farooq ul Abidin
Ocular surface squamous neoplasia (OSSN) is a term that describes the spectrum of abnormal growth of atypical squamous epithelial cells of the conjunctiva, cornea, and sclera. It is more common in people working for long in sun-exposed areas. It resembles other common ocular surface conditions such as pterygium, pinguecula, atopic conjunctivitis, diffuse episcleritis, chronic blepharoconjunctivitis which may result in the wrong diagnosis of the entity. Here we report a case of OSSN in a 25 years old man which was referred to us as a case of pterygium. An excisional biopsy revealed clusters of dysplastic squamous epithelial cells.
眼表鳞状瘤变(OSSN)是一个描述结膜、角膜和巩膜的非典型鳞状上皮细胞异常生长谱的术语。在阳光照射的地方长时间工作的人更常见。它类似于其他常见的眼表疾病,如翼状胬肉、钉状胬肉、特应性结膜炎、弥漫性表皮炎、慢性眼睑结膜炎,这些疾病可能导致对该实体的错误诊断。在这里,我们报告一个病例OSSN在一个25岁的男子被称为翼状胬肉的情况下。切除活检显示成团的发育不良鳞状上皮细胞。
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引用次数: 1
ISSUES OF WOMEN HEALTH IN NON-MUSLIM COMMUNITY OF KARACHI, PAKISTAN: A QUALITATIVE SURVEY 巴基斯坦卡拉奇非穆斯林社区妇女健康问题:一项定性调查
IF 0.5 Q3 Health Professions Pub Date : 2020-01-01 DOI: 10.46903/GJMS/18.03.852
Khalid Mahmood
Background: The women from non-Muslim community of Karachi have to face several issues regarding their health. The objective of this study was to find out the issues regarding the women health in non-Muslim community of Karachi and to provide suggestions in this context. Materials & Methods: This qualitative survey was conducted at Pakistan Study Center, University of Karachi, Pakistan from July 2011 to December 2011. Eleven Non-Muslim populated areas of Karachi were selected. The primary data was collected through structured interview schedule, including 15 open ended questions. One doctor from each cluster of the eleven minority populations was interviewed. The responses were noted on a notebook. The theme was to understand the health issues faced by women around fourteen concepts; provision of food to boys and girls, health of girls before marriage, health of girls after marriage, side effects of early age marriages, women’s health during pregnancy, role of midwife, presence of non-qualified practitioners, problems during maternity, concept of family planning, health facility during emergency, weight of children at the time of birth, mother feed for the children, role of dirty and polluted atmosphere, and diseases due to reserved professions. Results: There was a lack of awareness in the non-Muslim families of Karachi regarding provision of equal food to their children on the basis of sex. The physical health of girls before marriage was not good in these families. After marriage they are also at risk of mental illness due to poverty, illiteracy, uncomfortable residential units and having limited access to the lady doctors. The overcrowded houses and polluted atmosphere also affects badly their physical health. Conclusion: The non-Muslim women are deprived from health facilities due to socio-economic problems. It is the dire need to provide health education to the non-Muslim women in their settlements. Moreover, Health care facilities may be provided by establishing Basic Health Units, Rural Health Centers, Maternal & Child Health centers in these areas as per population density.
背景:来自卡拉奇非穆斯林社区的妇女在健康方面必须面对几个问题。这项研究的目的是找出卡拉奇非穆斯林社区妇女健康方面的问题,并在这方面提出建议。材料与方法:本定性调查于2011年7月至2011年12月在巴基斯坦卡拉奇大学巴基斯坦研究中心进行。卡拉奇的11个非穆斯林聚居区被选中。主要数据通过结构化访谈表收集,包括15个开放式问题。采访了11个少数民族群体中每组的一名医生。回答记在笔记本上。主题是围绕14个概念了解妇女面临的健康问题;向男孩和女孩提供食物、女孩婚前健康、女孩婚后健康、早婚的副作用、妇女怀孕期间的健康、助产士的作用、不合格从业人员的存在、产妇期间的问题、计划生育的概念、紧急情况下的保健设施、出生时儿童的体重、儿童的母亲喂养、肮脏和污染的空气的作用以及由保留职业引起的疾病。结果:卡拉奇的非穆斯林家庭缺乏基于性别为其子女提供平等食物的意识。这些家庭的女孩婚前身体健康状况不佳。结婚后,由于贫穷、文盲、不舒适的居住单位和很少有机会看女医生,她们也有患精神疾病的风险。拥挤的房屋和污染的空气也严重影响了他们的身体健康。结论:由于社会经济问题,非穆斯林妇女被剥夺了利用保健设施的权利。迫切需要向居住在其定居点的非穆斯林妇女提供健康教育。此外,可以根据人口密度在这些地区建立基本保健单位、农村保健中心、妇幼保健中心,从而提供保健设施。
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引用次数: 0
IMMUNOMODULATORY ROLE OF VITAMIN D: CLINICAL IMPLICATIONS IN INFECTIONS AND AUTOIMMUNE DISORDERS 维生素d的免疫调节作用:感染和自身免疫性疾病的临床意义
IF 0.5 Q3 Health Professions Pub Date : 2020-01-01 DOI: 10.46903/GJMS/18.03.841
F. K. Alswailmi, S. I. Shah, Haleema Nawaz
Vitamin D exerts its well-known effects on bone health and calcium-phosphate homeostasis primarily through the vitamin D receptor signaling pathway. Vitamin D also has several extra-skeletal actions and its deficiency is not only implicated in musculoskeletal disorders, but also cardiovascular disorders, diabetes, neurodegenerative conditions and cancers. There is a growing body of research highlighting the link of vitamin D deficiency and alterations in vitamin D signaling with certain infections and autoimmune disorders although the evidence is inconsistent and inconclusive. Vitamin D has been suggested to play a fundamental role in curbing infections and mitigating autoimmune disease processes. The present review was undertaken to explore the promise of vitamin D as a protective agent and a clinically useful therapeutic adjunct against infections and autoimmune diseases and identify knowledge gaps and limitations of the available data for informing future work. An exhaustive search was conducted in established databases including Google Scholar, PubMed, Science Direct and Springer for articles published on vitamin D, immunity, infection and autoimmune disorders. All relevant articles published in the English language between the year 200 and 2020 were retrieved for writing the review. Although a considerable body of evidence highlighting the potential clinical benefits of vitamin D against the development of various autoimmune conditions and for the prevention of infections has emerged over the last decade, the findings are limited by the lack of appropriately designed randomized controlled trials which are needed to formulate precise clinical recommendations.
维生素D主要通过维生素D受体信号通路对骨骼健康和磷酸钙稳态发挥其众所周知的作用。维生素D还具有多种骨骼外作用,缺乏维生素D不仅与肌肉骨骼疾病有关,还与心血管疾病、糖尿病、神经退行性疾病和癌症有关。越来越多的研究强调维生素D缺乏和维生素D信号改变与某些感染和自身免疫性疾病之间的联系,尽管证据不一致且不确定。维生素D被认为在抑制感染和减轻自身免疫性疾病过程中起着重要作用。本综述旨在探索维生素D作为预防感染和自身免疫性疾病的保护剂和临床有用的治疗辅助剂的前景,并确定现有数据的知识差距和局限性,为今后的工作提供信息。在谷歌Scholar、PubMed、Science Direct和施普林格等已建立的数据库中进行了详尽的搜索,以获取有关维生素D、免疫、感染和自身免疫性疾病的文章。检索了2000年至2020年间发表的所有相关英文文章,用于撰写综述。尽管在过去十年中出现了相当多的证据,强调维生素D对各种自身免疫性疾病的发展和预防感染的潜在临床益处,但由于缺乏适当设计的随机对照试验,需要制定精确的临床建议,这些发现受到限制。
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引用次数: 4
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Gomal Journal of Medical Sciences
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