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An Investigation on the Guideline Adherence in Opioid Addiction Treatment and the Causes of Nonadherences 阿片类药物成瘾治疗指南依从性及不依从性原因调查
IF 1.1 Q3 Medicine Pub Date : 2021-03-25 DOI: 10.1097/ADT.0000000000000254
S.M. Hesam Hoseiny Morasa, M. Haghighi, Sara Ataei, M. Rangchian
Objectives: This study was aimed to evaluate the level of adherence to the World Health Organization and American Society of Addiction Medicine guidelines regarding opioids addiction medications and to identify the causes of nonadherence, in Hamadan. Materials and Methods: The patients’ records were used to obtain data on the patients’ demographics and treatment process. The adherence to the mentioned guidelines was evaluated and reasons for nonadherence were asked from physicians. Results: At the time of the study, methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT) were the only common opioid addiction treatments in Hamadan. The number of the cases in BMT and MMT group was 18 and 142, respectively. The rate of the treatment course accomplishment (passing 4 stages) was 4.2% for MMT and 0% for BMT. In the induction phase, the adherence rates regarding initial dosing and regular weekly visits were 66.7 and 27.8% for BMT, beside 27.5, and 60.6% for MMT. Concerning the stabilization stage, the dosage amount, dose modification, and regular visits, respectively, 41.5%, 24.6%, and 27.5% of MMT cases were performed in adherence to the guidelines, whereas adherence of dose selection for BMT was 11.1%. In the MMT elimination stage, 33.3% compliance was observed; no case of BMT had continued the treatment to this stage. No discrepancy was because of the physicians’ disbelief in clinical guidelines; they were either aimed to tailor the treatment with a patient’s condition or resulted from familial, sociocultural, and financial problems. Conclusions: Overall, enhancement of patients and their families’ awareness about medication process appears necessary.
目的:本研究旨在评估哈马丹对世界卫生组织和美国成瘾医学学会关于阿片类药物成瘾药物指南的遵守程度,并确定不遵守指南的原因。材料与方法:利用患者病历资料获取患者的人口统计资料和治疗过程资料。对上述指南的依从性进行了评估,并向医生询问了不遵守指南的原因。结果:在研究时,美沙酮维持治疗(MMT)和丁丙诺啡维持治疗(BMT)是哈马丹唯一常见的阿片类药物成瘾治疗。BMT组18例,MMT组142例。MMT的疗程完成率(通过4个阶段)为4.2%,BMT为0%。在诱导阶段,BMT的初始给药依从率和每周定期就诊依从率分别为66.7和27.8%,MMT的依从率分别为27.5和60.6%。稳定期阶段,MMT患者中41.5%、24.6%和27.5%的患者在剂量选择、剂量调整和定期就诊方面均遵循指南,而BMT患者的剂量选择遵循指南的比例为11.1%。在MMT消除阶段,依从性为33.3%;没有BMT病例继续治疗到这个阶段。差异不是因为医生不相信临床指南;它们要么是为了根据病人的情况量身定制治疗方案,要么是由于家庭、社会文化和经济问题。结论:总体而言,提高患者及其家属对用药过程的认识是必要的。
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引用次数: 0
Impulsivity and Decision-making Style Among Tramadol Drug Addicts and its Relation to Frontal Lobe Volume 曲马多吸毒者的冲动性、决策方式及其与额叶容积的关系
IF 1.1 Q3 Medicine Pub Date : 2021-03-24 DOI: 10.1097/ADT.0000000000000256
K. Elbeh, Y. Elserogy, G. Seifeldein, S. Mostafa, H. Yousef, M. Fawzy
Objectives: Drug addiction has its effects on different behavioral and personality traits including impulsivity and pattern of decision-making. The frontal lobe was the focus of many of these studies regarding its important role in decision-making and other higher cognitive processes. We aimed to detect the pattern of decision-making styles and impulsivity among people with tramadol addiction, and also to find out if tramadol addiction has effects on the volume of different regions of the frontal lobe. Materials and Methods: Two groups were included: group A included 12 patients with tramadol addiction and group B included 23 healthy cross-matching controls. Both groups were subjected to urine drug screening, Iowa gambling task (IGT), UPPS scales (negative urgency, lack of perseverance, lack of premeditation, and sensation seeking), and structural magnetic resonance imaging brain study. Results: The patients’ group has shown a significantly lower volume of the brain white matter, gray matter, and cortical thickness (P<0.001). This group has also shown a significantly higher scores of IGT-A and IGT-B (P<0.001 and P=0.02, respectively) and has shown a higher score of all subscales of UPPS. Conclusions: Tramadol addiction is associated with a reduced volume of the brain white matter, gray matter, and cortical thickness. All regions of the frontal lobe have shown significant volume reduction in the tramadol group. Tramadol addiction and its duration are associated with risky decision-making style and with higher impulsivity than nonaddicts.
目的:药物成瘾对不同的行为和人格特征有影响,包括冲动性和决策模式。额叶是许多关于其在决策和其他高级认知过程中的重要作用的研究的焦点。我们旨在检测曲马多成瘾患者的决策风格和冲动模式,并了解曲马多上瘾是否对额叶不同区域的体积有影响。材料和方法:分为两组:A组包括12名曲马多成瘾患者,B组包括23名健康对照。两组都接受了尿液药物筛查、爱荷华州赌博任务(IGT)、UPPS量表(负紧迫感、缺乏毅力、缺乏预谋和寻求感觉)和大脑结构磁共振成像研究。结果:患者组的脑白质、灰质和皮质厚度明显较低(P<0.001)。该组的IGT-a和IGT-B得分也明显较高(分别为P<0.001和P=0.02),UPPS的所有分量表得分均较高。结论:曲马多成瘾与脑白质、灰质和皮质厚度减少有关。曲马多组额叶的所有区域都显示出明显的体积减少。曲马多成瘾及其持续时间与风险决策风格有关,与非成瘾者相比冲动性更高。
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引用次数: 0
Cannabis Use and Cognitive Impairment Among Male Adolescents: A Case-control Study 男性青少年大麻使用与认知障碍的病例对照研究
IF 1.1 Q3 Medicine Pub Date : 2021-03-24 DOI: 10.1097/ADT.0000000000000257
Medhat M. Bassiony, Haidy K. Ammar, Yomna Khalil
Cannabis use by adolescents is a public health problem because it can cause cognitive impairment and educational deterioration. The objective of this study was to assess the prevalence and correlates of cognitive impairment among male adolescents with cannabis use in comparison with a control group. This is a case-control study that included 1682 adolescents who just finished their secondary school. A drug screen was made for all participants. Cognitive assessment using Montreal Cognitive Assessment (MoCA) scale was carried out for adolescents with positive urine screen for cannabis and a control group of adolescents with negative urine screen for drugs. The prevalence of cannabis use among adolescents was 2.14%. About one third of the cases started to use cannabis before the age of 15 years. Fifty-six percent used cannabis frequently (>4 times/wk). Adolescents with cannabis use were more likely to have cognitive impairment based on MoCA than controls (78% vs. 44%, P=0.004). Cases were more likely to have impairment in naming, abstraction, orientation, and total MoCA score than controls. Adolescents who started cannabis use early (below 15 y) had impairment in visuospatial/executive, attention, language, abstraction, delayed recall, and total MoCA score compared with those who started late (above 15 y). In addition, adolescents who use cannabis frequently had impairment in all cognitive domains except naming compared with those who used it occasionally. To conclude, the current study found that adolescents with cannabis use were more likely to have cognitive impairment than controls and this impairment was associated with age of onset and frequency of cannabis use.
青少年使用大麻是一个公共卫生问题,因为它会导致认知障碍和教育恶化。本研究的目的是与对照组相比,评估男性青少年使用大麻的认知障碍的患病率和相关性。这是一项病例对照研究,包括1682名刚刚完成中学学业的青少年。对所有参与者进行了药物筛选。使用蒙特利尔认知评估量表对大麻尿液筛查呈阳性的青少年和药物尿液筛查呈阴性的对照组青少年进行了认知评估。青少年使用大麻的流行率为2.14%。大约三分之一的病例在15岁之前开始使用大麻。56%的人经常吸食大麻(每周4次以上)。与对照组相比,使用大麻的青少年更有可能出现基于MoCA的认知障碍(78%对44%,P=0.004)。与对照组比较,病例更有可能在命名、抽象、定向和MoCA总分方面出现障碍。早期(15岁以下)开始使用大麻的青少年 y) 与起步较晚的人相比,在视觉空间/执行力、注意力、语言、抽象、延迟回忆和MoCA总分方面存在障碍(超过15 y) 。此外,与偶尔使用大麻的人相比,经常使用大麻的青少年在除命名外的所有认知领域都有障碍。总之,目前的研究发现,使用大麻的青少年比对照组更有可能出现认知障碍,这种障碍与发病年龄和使用大麻的频率有关。
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引用次数: 1
Using TikTok App for Therapy and Sharing Happiness in COVID-19 Outbreak 在新冠肺炎疫情中使用TikTok应用程序进行治疗和分享快乐
IF 1.1 Q3 Medicine Pub Date : 2021-03-17 DOI: 10.1097/ADT.0000000000000255
D. Situmorang
Through this article, the author also to encourage every person in the world will recognize music and dance as a good alternative through this article. People who are currently struggling to care for the psychological health of everyone in their respective countries are required to be able to provide support through collective music and dance activities, such as inviting everyone to dance together with TikTok App.
通过这篇文章,作者也鼓励世界上的每一个人都认识到音乐和舞蹈是一个很好的替代品。目前正在努力照顾各自国家每个人心理健康的人需要能够通过集体音乐和舞蹈活动提供支持,例如邀请每个人使用TikTok应用程序一起跳舞。
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引用次数: 14
Harm Perceptions of E-cigarette Use Among New Zealand Young People: Development of a Questionnaire 新西兰年轻人对电子烟使用的危害感知:一份问卷的编制
IF 1.1 Q3 Medicine Pub Date : 2021-03-17 DOI: 10.1097/ADT.0000000000000252
Oliver Birch, D. Newcombe, C. Bullen
Supplemental Digital Content is available in the text. Objectives: E-cigarette use is growing among New Zealand young people, yet their perceptions of the harms of e-cigarette use are unknown. This study aimed to determine domains and specific items for inquiry to inform the creation of a questionnaire assessing the perceptions of harms of e-cigarette use in this group. Materials and Methods: An integrative literature review generated a preliminary list of survey items and domains. A Delphi study involving 6 expert academics was undertaken to verify and refine this list. The consensus was facilitated through online, structured communication. Results: Previous data collection attempts included items assessing participants’ knowledge of e-cigarettes, their current e-cigarette and cigarette use, and how harmful they perceived e-cigarettes to be relative to cigarettes. The Delphi study refined the initial list of items while contributing additional considerations. A total of 54 items were organized into 7 domains: “E-cigarette Knowledge,” “Cigarette Use,” “E-cigarette Use,” “E-cigarette Relative Harm,” “E-cigarette Promotion,” “Acceptability (E-cigarettes and Cigarettes)”, and (“General Introduction”) items on participants’ identity characteristics (gender, age, ethnicity). Conclusions: Each of the items will inform the design of a questionnaire assessing New Zealand young people’s perceptions of the harms of e-cigarette use. Development of these items will involve further literature reviewing, focus groups with end-users, and a pilot study.
文本中提供了补充数字内容。目标:新西兰年轻人越来越多地使用电子烟,但他们对使用电子烟危害的认识尚不清楚。这项研究旨在确定调查的领域和具体项目,为制定一份评估这一群体使用电子烟危害的问卷提供信息。材料和方法:综合文献综述生成了调查项目和领域的初步列表。为了核实和完善这份清单,进行了一项涉及6名专家学者的德尔菲研究。通过在线结构化沟通促进了协商一致。结果:之前的数据收集尝试包括评估参与者对电子烟的了解、他们目前的电子烟和香烟使用情况,以及他们认为电子烟相对于香烟的危害程度。德尔菲研究完善了最初的项目清单,同时提供了额外的考虑因素。共有54个项目被分为7个领域:“电子烟知识”、“吸烟”、“电子烟使用”、“网络烟相对危害”、“推广网络烟”、“可接受性(网络烟和香烟)”和(“一般介绍”)关于参与者身份特征(性别、年龄、种族)的项目。结论:每一项都将为评估新西兰年轻人对使用电子烟危害的看法的问卷设计提供信息。这些项目的开发将涉及进一步的文献审查、与最终用户的焦点小组以及一项试点研究。
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引用次数: 0
Effect of Naltrexone on Interleukins 2 and 4 in a Sample of Egyptian Patients With Heroin Use Disorder: A Prospective Case-control Study 纳曲酮对埃及海洛因使用障碍患者白细胞介素2和4的影响:一项前瞻性病例对照研究
IF 1.1 Q3 Medicine Pub Date : 2021-03-03 DOI: 10.1097/ADT.0000000000000251
Omnia A.E.A. Mesalhy, O. Ali, M. Elhabiby, Fatma Alzahraa M Hassan, O. Elgamel, Ola M. Aufa
Objectives: Opiates, particularly heroin, have been used for centuries for their positive reinforcing properties that lead to addiction. Naltrexone (NTX), an opioid antagonist, is capable of reducing these positive reinforcing effects. Heroin affects the immune system through its action on the interleukins (ILs). This study aimed to determine changes in the level of IL-2 and IL-4 in patients with heroin use disorder compared with healthy controls. Materials and Methods: This was a prospective case-control study conducted on 25 patients with heroin use disorder and 20 cross-matched healthy controls. We compared the levels of IL-2 and IL-4 between patients and controls and determined the changes that occurred to IL-2 and IL-4 during 4 different stages (during active use, 1 mo after abstinence, 1 and 4 mo after NTX treatment). It also evaluated the effect of dose and duration of heroin use on the level of ILs before and after NTX treatment. Results: This study revealed that patients showed a significantly lower level of IL-2 and a higher level of IL-4 in the patients’ group compared with the control group during active use and 1 month after discontinuation while these significant differences disappeared after NTX treatment. Serum IL-4 level was affected by both heroin dose and duration of use. Conclusion: Heroin use negatively affects immunity by changing the level of IL-2 and IL-4 while NTX reversed this effect, so the study approved the beneficial use of NTX treatment on the immunity system in patients with heroin use disorder.
目的:阿片类药物,特别是海洛因,由于其积极增强的特性导致成瘾,已经使用了几个世纪。纳曲酮(NTX),阿片类拮抗剂,能够减少这些积极的强化作用。海洛因通过对白细胞介素(il)的作用影响免疫系统。本研究旨在确定与健康对照相比,海洛因使用障碍患者IL-2和IL-4水平的变化。材料与方法:本研究是一项前瞻性病例对照研究,对25例海洛因使用障碍患者和20例交叉匹配的健康对照进行研究。我们比较了患者和对照组之间IL-2和IL-4的水平,并确定了4个不同阶段(积极使用期间,戒断后1个月,NTX治疗后1和4个月)IL-2和IL-4的变化。它还评估了海洛因使用剂量和持续时间对NTX治疗前后il水平的影响。结果:本研究显示,与对照组相比,患者在积极使用期间和停药1个月后,患者组IL-2水平明显降低,IL-4水平明显升高,而经NTX治疗后,这些显著差异消失。血清IL-4水平受海洛因剂量和使用时间的影响。结论:海洛因使用通过改变IL-2和IL-4水平对免疫系统产生负性影响,而NTX则逆转了这一作用,因此本研究证实了NTX治疗对海洛因使用障碍患者免疫系统的有益作用。
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引用次数: 0
Gender Differences in Clinical and Sociodemographic Patterns of Substance Use Disorder: Erratum 物质使用障碍临床和社会形态的性别差异:勘误表
IF 1.1 Q3 Medicine Pub Date : 2021-02-24 DOI: 10.1097/adt.0000000000000247
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引用次数: 0
Pattern of Tobacco Smoking Among Egyptian Patients With Bipolar Disorder 埃及双相情感障碍患者的吸烟模式
IF 1.1 Q3 Medicine Pub Date : 2021-02-19 DOI: 10.1097/ADT.0000000000000248
E. Shorub, H. Elshahawi, Menan Abdel Maksooud, M. Wagdy, Maissa Eid
Background: Individuals with bipolar disorder (BD) have a higher prevalence of tobacco smoking than the general population. In Egypt, the accurate data about the pattern of tobacco smoking and prevalence of nicotine dependence among BD patients are still scarce. Objective: The objective of this study was to detect the pattern of tobacco smoking and to assess the occurrence of nicotine dependence syndrome among Egyptian cigarette and waterpipe smoker patients suffering from BD. Methods: A cross-sectional study using a semistructured interview to assess 100 patients with BD at the inpatient department and the outpatient mood clinic of The Institute of Psychiatry, Ain Shams University. The assessment tools included the Mini-International Neuropsychiatric Interview, Sixth Edition (M.I.N.I.), the Young Mania Rating Scale (YMRS), the Fagerström Test for Nicotine Dependence (FTND), and the Lebanon Waterpipe Dependence Scale (LWDS-11). Results: Of the 100 recruited bipolar patients (43% women and 57% men), it was found that 45% of bipolar cases were cigarette smokers, 18% were waterpipe smokers, and 17% smoked both cigarette and waterpipe with a statistically significant difference. Bipolar I in the acute phase showed the most prevalent type of BDs with moderate (31%) and high (13.8%) nicotine dependence. Bipolar II cases have never smoked neither cigarette nor waterpipe; 5% of patients with bipolar I smoked waterpipe during disease activity. Conclusion: Patients with BD have a relatively high frequency of nicotine (cigarettes and waterpipe) dependence (17%) in relation to the general population (1.0%), especially bipolar I type.
背景:双相情感障碍患者的吸烟率高于普通人群。在埃及,关于BD患者吸烟模式和尼古丁依赖率的准确数据仍然很少。目的:本研究的目的是检测患有BD的埃及香烟和水烟患者的吸烟模式,并评估其尼古丁依赖综合征的发生率。方法:采用半结构化访谈的横断面研究,对艾因沙姆斯大学精神病学研究所住院部和门诊情绪诊所的100名BD患者进行评估。评估工具包括迷你国际神经心理访谈,第六版(M.I.N.I.)、青少年躁狂评定量表(YMRS)、尼古丁依赖FagerströM测试(FTND)和黎巴嫩水管依赖量表(LWDS-11)。结果:在招募的100名双相情感障碍患者(43%的女性和57%的男性)中,发现45%的双相情感症患者吸烟,18%的患者水烟,17%的患者同时吸烟和水烟,差异具有统计学意义。急性期的双相情感障碍I表现出最普遍的BDs类型,具有中度(31%)和高度(13.8%)的尼古丁依赖性。双相情感障碍II患者从未吸烟,也从未使用过水管;5%的双相情感障碍I患者在疾病活动期间吸烟。结论:BD患者对尼古丁(香烟和水管)依赖的频率相对较高(17%),而普通人群(1.0%),尤其是双相I型。
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引用次数: 0
Increased Consumption of Crystal (Methamphetamine) During the COVID-19 Outbreak 新冠肺炎疫情期间水晶(甲基苯丙胺)消费量增加
IF 1.1 Q3 Medicine Pub Date : 2021-02-19 DOI: 10.1097/ADT.0000000000000250
M. Naeim, A. Rezaeisharif
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引用次数: 7
Predictors of Drug Abuse Relapse for Iranian Addicted Women: An Application of Social Cognitive Theory 伊朗吸毒妇女药物滥用复发的预测因素:社会认知理论的应用
IF 1.1 Q3 Medicine Pub Date : 2021-02-16 DOI: 10.1097/ADT.0000000000000249
S. Bashirian, M. Barati, Y. Mohammadi, Hadi Ghazanfari Zarnagh, S. Bagheri
Objectives: Substance abuse prevalence has risen over the past decade among women, and accordingly, sex-specific barriers impede women’s access and participation in treatment programs, while the chief issue in providing treatment programs for women with substance abuse is the high relapse rate seen in the subjects. With all these in mind, the present study was conducted with the objective of recognizing the sociocognitive factors that concern the relapse of substance abuse in women. Methods: Two hundred women subjects under treatment in outpatient addiction treatment and rehabilitation centers in Kurdistan province in 2019 participated in this descriptive study. Data were obtained by means of a questionnaire that included demographic questions, history of substance use, and structures of social cognitive theory. Data were analyzed by SPSS software version 21 that further used logistic regression, χ2, and independent t tests. Results: The average age of the respondents was estimated 37.75±10.49. The relapse rate amounted to 80% among the participants. Logistic regression test analysis designated that the structures of situational perception, social support, and self-efficacy act as the factors that predict substance abuse relapses in women (R=0.42; P<0.05). Conclusions: Social cognitive theory is considered a valid theoretical method for deciphering the relation observed between substance abuse relapse predictors in women. Therapists’ consciousness on gaining social support and strengthening self-efficacy in the subjects may serve to improve the aftermaths of substance abuse treatment programs in women.
目标:在过去十年中,女性的药物滥用流行率有所上升,因此,特定性别的障碍阻碍了女性获得和参与治疗计划,而为药物滥用女性提供治疗计划的主要问题是受试者的高复发率。考虑到所有这些,本研究的目的是认识到与妇女药物滥用复发有关的社会认知因素。方法:2019年在库尔德斯坦省门诊成瘾治疗和康复中心接受治疗的200名女性受试者参与了这项描述性研究。数据是通过问卷调查获得的,其中包括人口统计学问题、物质使用史和社会认知理论结构。数据通过SPSS 21版软件进行分析,该软件进一步使用逻辑回归、χ2和独立t检验。结果:调查对象的平均年龄估计为37.75±10.49岁。参与者的复发率达到80%。Logistic回归检验分析表明,情境感知、社会支持和自我效能结构是预测女性药物滥用复发的因素(R=0.42;P<0.05)。治疗师在受试者中获得社会支持和增强自我效能的意识可能有助于改善女性药物滥用治疗项目的后遗症。
{"title":"Predictors of Drug Abuse Relapse for Iranian Addicted Women: An Application of Social Cognitive Theory","authors":"S. Bashirian, M. Barati, Y. Mohammadi, Hadi Ghazanfari Zarnagh, S. Bagheri","doi":"10.1097/ADT.0000000000000249","DOIUrl":"https://doi.org/10.1097/ADT.0000000000000249","url":null,"abstract":"Objectives: Substance abuse prevalence has risen over the past decade among women, and accordingly, sex-specific barriers impede women’s access and participation in treatment programs, while the chief issue in providing treatment programs for women with substance abuse is the high relapse rate seen in the subjects. With all these in mind, the present study was conducted with the objective of recognizing the sociocognitive factors that concern the relapse of substance abuse in women. Methods: Two hundred women subjects under treatment in outpatient addiction treatment and rehabilitation centers in Kurdistan province in 2019 participated in this descriptive study. Data were obtained by means of a questionnaire that included demographic questions, history of substance use, and structures of social cognitive theory. Data were analyzed by SPSS software version 21 that further used logistic regression, χ2, and independent t tests. Results: The average age of the respondents was estimated 37.75±10.49. The relapse rate amounted to 80% among the participants. Logistic regression test analysis designated that the structures of situational perception, social support, and self-efficacy act as the factors that predict substance abuse relapses in women (R=0.42; P<0.05). Conclusions: Social cognitive theory is considered a valid theoretical method for deciphering the relation observed between substance abuse relapse predictors in women. Therapists’ consciousness on gaining social support and strengthening self-efficacy in the subjects may serve to improve the aftermaths of substance abuse treatment programs in women.","PeriodicalId":44600,"journal":{"name":"Addictive Disorders & Their Treatment","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46059215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
Addictive Disorders & Their Treatment
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