Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p192-p199
Dr.N.L. Prasanthi, N. Aditya, Sampathirao Sai Jeevan, Tadi Srinivas Varma, Lakshmi Srinulu Nulu, Dr.K. Venkateswara Raju
At present, biosimilar projects are ruling the pharma market. This article aims to show that project management is crucialin developing biosimilars. Bad project management will give a bad reputation to the organization, project cost overruns, projectschedule delays, demotivation of the project team, sustainability risk to the organization, and more over huge loss. It is the main reasonmost companies are spending more on the training of employees, particularly on project management. Biosimilars are biologicalproducts that are highly similar to a reference product despite modest changes in therapeutically inactive components. Biosimilarshave no clinically significant changes in product safety, purity, or potency compared to the reference product. With the imminentpatent expiration of certain important high-cost biologics, biosimilar manufacture is becoming increasingly profitable for firms.However, the introduction of biosimilars necessitates the adoption of critical new rules. Because of the inherent differences involvedwith the production methods used by different companies and even different sites within the same company, the existing standardsthat regulate the approval pathways for generic pharmaceuticals are insufficient for biosimilars. Biosimilars are similar to but notidentical to the original. Due to the exclusive nature of the manufacturing line and the techniques employed by these competitors,basic variances in methodology may exist between competing organizations. Even modest variations in the manufacturing process canresult in micro heterogeneity, characterized by minor differences in molecular structure, stability, production cell line behavior, growthconditions, vectors, and purification methods. For these reasons, developing biosimilars takes a lot of work.1 CBER regulatesbiosimilars in the US Market. The reference Medicine's Patent status and market potential should be considered when developingbiosimilars. The main objective of this article is to show that the project management strategies and regulatory approval process areequally important to enter biosimilars into the market. Concerning quality in the project management of biosimilar products, budget,deadlines, and scopes are major constraints. A Gantt chart has been enacted to represent a graphical illustration of a schedule. Ganttchart helps to plan, coordinate, and track specific tasks in a project.
{"title":"Regulatory Guidelines and Production Planning Strategies for Biosimilars in the USA","authors":"Dr.N.L. Prasanthi, N. Aditya, Sampathirao Sai Jeevan, Tadi Srinivas Varma, Lakshmi Srinulu Nulu, Dr.K. Venkateswara Raju","doi":"10.22376/ijlpr.2023.13.6.p192-p199","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p192-p199","url":null,"abstract":"At present, biosimilar projects are ruling the pharma market. This article aims to show that project management is crucialin developing biosimilars. Bad project management will give a bad reputation to the organization, project cost overruns, projectschedule delays, demotivation of the project team, sustainability risk to the organization, and more over huge loss. It is the main reasonmost companies are spending more on the training of employees, particularly on project management. Biosimilars are biologicalproducts that are highly similar to a reference product despite modest changes in therapeutically inactive components. Biosimilarshave no clinically significant changes in product safety, purity, or potency compared to the reference product. With the imminentpatent expiration of certain important high-cost biologics, biosimilar manufacture is becoming increasingly profitable for firms.However, the introduction of biosimilars necessitates the adoption of critical new rules. Because of the inherent differences involvedwith the production methods used by different companies and even different sites within the same company, the existing standardsthat regulate the approval pathways for generic pharmaceuticals are insufficient for biosimilars. Biosimilars are similar to but notidentical to the original. Due to the exclusive nature of the manufacturing line and the techniques employed by these competitors,basic variances in methodology may exist between competing organizations. Even modest variations in the manufacturing process canresult in micro heterogeneity, characterized by minor differences in molecular structure, stability, production cell line behavior, growthconditions, vectors, and purification methods. For these reasons, developing biosimilars takes a lot of work.1 CBER regulatesbiosimilars in the US Market. The reference Medicine's Patent status and market potential should be considered when developingbiosimilars. The main objective of this article is to show that the project management strategies and regulatory approval process areequally important to enter biosimilars into the market. Concerning quality in the project management of biosimilar products, budget,deadlines, and scopes are major constraints. A Gantt chart has been enacted to represent a graphical illustration of a schedule. Ganttchart helps to plan, coordinate, and track specific tasks in a project.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"7 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p277-p286
Shreya Talreja, Dr Shashank Tiwari
Primula vulgaris, also known as the common or English primrose, is a perennial herbaceous plant renowned for itsdelicate and vibrant flowers. Embedded in various traditions, this charming species holds cultural significance associated with spring,love, and healing. Throughout history, it has been utilized in traditional medicine for its potential medicinal properties, includinganti-inflammatory effects, skin health benefits, and hormonal balance support. Recent scientific research has delved into exploringthe phytochemical composition of primrose and its therapeutic potential. Studies have revealed the presence of compounds likesaponins, flavonoids, phenolic acids, and essential fatty acids, which contribute to its reported medicinal effects. However, theapplications of primrose extend beyond medicine; it also finds use in culinary and cosmetic practices. The flowers serve as ediblegarnishes in salads, desserts, and beverages, while primrose oil extracted from the seeds is valued in the cosmetic industry for skincare and hair care applications. In addition to its various uses, botanical science research has focused on primrose's geneticdiversity, ecological significance, and potential roles in climate change adaptation. Consequently, conservation efforts are underwayto protect its natural habitats and preserve its biodiversity. This paper aims to provide a comprehensive overview of Primulavulgaris, covering its cultural, medicinal, culinary, and ecological aspects. By examining its historical significance, traditional uses inmedicine, and scientific evidence supporting its potential benefits, the paper seeks to emphasize the enduring symbolism ofprimrose, a testament to beauty, tradition, and the intricate relationship between humanity and the natural world. As ongoingresearch unveils its hidden potential, primrose remains a fascinating subject for scientific exploration and cultural appreciation.
{"title":"Complete Overview On Primula Vulgaris","authors":"Shreya Talreja, Dr Shashank Tiwari","doi":"10.22376/ijlpr.2023.13.6.p277-p286","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p277-p286","url":null,"abstract":"Primula vulgaris, also known as the common or English primrose, is a perennial herbaceous plant renowned for itsdelicate and vibrant flowers. Embedded in various traditions, this charming species holds cultural significance associated with spring,love, and healing. Throughout history, it has been utilized in traditional medicine for its potential medicinal properties, includinganti-inflammatory effects, skin health benefits, and hormonal balance support. Recent scientific research has delved into exploringthe phytochemical composition of primrose and its therapeutic potential. Studies have revealed the presence of compounds likesaponins, flavonoids, phenolic acids, and essential fatty acids, which contribute to its reported medicinal effects. However, theapplications of primrose extend beyond medicine; it also finds use in culinary and cosmetic practices. The flowers serve as ediblegarnishes in salads, desserts, and beverages, while primrose oil extracted from the seeds is valued in the cosmetic industry for skincare and hair care applications. In addition to its various uses, botanical science research has focused on primrose's geneticdiversity, ecological significance, and potential roles in climate change adaptation. Consequently, conservation efforts are underwayto protect its natural habitats and preserve its biodiversity. This paper aims to provide a comprehensive overview of Primulavulgaris, covering its cultural, medicinal, culinary, and ecological aspects. By examining its historical significance, traditional uses inmedicine, and scientific evidence supporting its potential benefits, the paper seeks to emphasize the enduring symbolism ofprimrose, a testament to beauty, tradition, and the intricate relationship between humanity and the natural world. As ongoingresearch unveils its hidden potential, primrose remains a fascinating subject for scientific exploration and cultural appreciation.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"7 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l549-l556
K. Muthulakshmi, G. Thirulogachandar, V. Saravanan, P. Priyadharshini, K. Saraswathi, P. Sowmiya, M. Sivasakthi
Diastasis recti abdominis (DRA) has been defined as an impairment characterized by the split of the rectus abdominismuscle along with the linea Alba. Diastasis Rectus Abdominis Muscle is familiar during pregnancy and later pregnancy and hasbeen connected to lumbopelvic stability and pelvic floor weakness. The study aims to find the effect of deep core stabilityexercise and kinesio-taping therapy techniques in diastasis recti. This is an experimental design with pre and post-comparativestudy. The study setting is at the Faculty of Physiotherapy ACS Medical College and Hospital 30 samples were selected, andintervention was carried out for about 4 weeks. If diastasis recti abdominis was present at 8 weeks postpartum, either vaginaldelivery or cesarean section were options. Less than 8 weeks after giving birth, the following ailments were excluded:respiratory illnesses, sensory defects, neurological disorders, hypertension, diabetes mellitus, heart conditions, abdominalsurgeries, vaginal hemorrhage, skin conditions, pregnancy, obesity, and neoplastic diseases. In Group-A, 15 subjects receiveddeep core stability exercises and Kinesio taping, while Group-B, 15 received Traditional abdominal exercises. The outcome toolswere the digital nylon caliper and finger breath. On comparing the Pretest and Posttest within Group A & Group B on DigitalNylon Caliper (Above Umbilicus and below Umbilicus) score & finger Breadths (Above Umbilicus and below Umbilicus) scoreshows a significant difference in the mean values at P ≤ 0.05. This study concluded that deep core stability exercise and kinesiotaping therapy techniques effectively reduce diastasis recti in postpartum women; they help restore postpartum abdominalefficiency. These exercises could be effective in narrowing the inter-recti distance. The result shows that deep core stabilityexercise and kinesio taping therapy techniques significantly reduce diastasis recti.
{"title":"Deep Core Stability Exercise Along with Kinesio Taping Therapy Techniques for Diastasis Recti Abdominis","authors":"K. Muthulakshmi, G. Thirulogachandar, V. Saravanan, P. Priyadharshini, K. Saraswathi, P. Sowmiya, M. Sivasakthi","doi":"10.22376/ijlpr.2023.13.6.l549-l556","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l549-l556","url":null,"abstract":"Diastasis recti abdominis (DRA) has been defined as an impairment characterized by the split of the rectus abdominismuscle along with the linea Alba. Diastasis Rectus Abdominis Muscle is familiar during pregnancy and later pregnancy and hasbeen connected to lumbopelvic stability and pelvic floor weakness. The study aims to find the effect of deep core stabilityexercise and kinesio-taping therapy techniques in diastasis recti. This is an experimental design with pre and post-comparativestudy. The study setting is at the Faculty of Physiotherapy ACS Medical College and Hospital 30 samples were selected, andintervention was carried out for about 4 weeks. If diastasis recti abdominis was present at 8 weeks postpartum, either vaginaldelivery or cesarean section were options. Less than 8 weeks after giving birth, the following ailments were excluded:respiratory illnesses, sensory defects, neurological disorders, hypertension, diabetes mellitus, heart conditions, abdominalsurgeries, vaginal hemorrhage, skin conditions, pregnancy, obesity, and neoplastic diseases. In Group-A, 15 subjects receiveddeep core stability exercises and Kinesio taping, while Group-B, 15 received Traditional abdominal exercises. The outcome toolswere the digital nylon caliper and finger breath. On comparing the Pretest and Posttest within Group A & Group B on DigitalNylon Caliper (Above Umbilicus and below Umbilicus) score & finger Breadths (Above Umbilicus and below Umbilicus) scoreshows a significant difference in the mean values at P ≤ 0.05. This study concluded that deep core stability exercise and kinesiotaping therapy techniques effectively reduce diastasis recti in postpartum women; they help restore postpartum abdominalefficiency. These exercises could be effective in narrowing the inter-recti distance. The result shows that deep core stabilityexercise and kinesio taping therapy techniques significantly reduce diastasis recti.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"54 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l32-l36
Dr. K. Sumathi, Ms. V.P. Nivedhini, Dr. Jainulavudeen Mohamed Rabeek
Ascites are the accumulation of fluid in the Abdomen. It happens due to clinical complications from various diseasesthat cause signs and symptoms. Cirrhosis, malignant ascites, and abdominal tuberculosis are the most common causes of ascites.The multiple etiologies of ascites make determining the cause difficult. Several techniques can aid in the differential diagnosis ofascites. However, the techniques are more expensive, invasive, and require more time. As a result, a less expensive and fastermethod of diagnosis, at least as a screening test, would greatly benefit clinicians. Albumin and Cholesterol in serum and ascitic fluidare parameters that would help screen and diagnose cancer. The serum-ascites albumin gradient or gap (SAAG) is a medicalcalculation that helps determine the cause of ascites. In addition, the serum ascites cholesterol gradient (SACG) aids in thedifferential diagnosis.The case study aims to evaluate the significance of serum-ascites cholesterol gradient (SACG) in diagnosingovarian carcinoma. This case report includes a 53-year-old woman who presented to the surgical department with anorexia,indigestion, heartburn, pain or discomfort in the abdominal and pelvic regions, nausea, early satiety, bloating, and weight loss for1 month. She was diagnosed with ovarian carcinoma. The gradients of serum-ascites albumin and serum-ascites Cholesterol werecalculated. Later, the results were compared to Ca-125, an ovarian cancer marker. SAAG showed low sensitivity but high specificityand poor diagnostic performance. Her diagnosis of ovarian carcinoma was confirmed and she was advised to follow up with theoncologist. The current case report will help understand the contribution of the ascitic fluid and serum parameters in a case ofovarian cancer with ascites of unknown etiology.
{"title":"Case Report On Diagnosis of Malignancy with Serum-Ascites Cholesterol Gradient","authors":"Dr. K. Sumathi, Ms. V.P. Nivedhini, Dr. Jainulavudeen Mohamed Rabeek","doi":"10.22376/ijlpr.2023.13.6.l32-l36","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l32-l36","url":null,"abstract":"Ascites are the accumulation of fluid in the Abdomen. It happens due to clinical complications from various diseasesthat cause signs and symptoms. Cirrhosis, malignant ascites, and abdominal tuberculosis are the most common causes of ascites.The multiple etiologies of ascites make determining the cause difficult. Several techniques can aid in the differential diagnosis ofascites. However, the techniques are more expensive, invasive, and require more time. As a result, a less expensive and fastermethod of diagnosis, at least as a screening test, would greatly benefit clinicians. Albumin and Cholesterol in serum and ascitic fluidare parameters that would help screen and diagnose cancer. The serum-ascites albumin gradient or gap (SAAG) is a medicalcalculation that helps determine the cause of ascites. In addition, the serum ascites cholesterol gradient (SACG) aids in thedifferential diagnosis.The case study aims to evaluate the significance of serum-ascites cholesterol gradient (SACG) in diagnosingovarian carcinoma. This case report includes a 53-year-old woman who presented to the surgical department with anorexia,indigestion, heartburn, pain or discomfort in the abdominal and pelvic regions, nausea, early satiety, bloating, and weight loss for1 month. She was diagnosed with ovarian carcinoma. The gradients of serum-ascites albumin and serum-ascites Cholesterol werecalculated. Later, the results were compared to Ca-125, an ovarian cancer marker. SAAG showed low sensitivity but high specificityand poor diagnostic performance. Her diagnosis of ovarian carcinoma was confirmed and she was advised to follow up with theoncologist. The current case report will help understand the contribution of the ascitic fluid and serum parameters in a case ofovarian cancer with ascites of unknown etiology.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tooth erosion is the loss of tooth structure caused by chemical dissolution without the involvement of oral bacteria. Thisstudy aimed to assess the knowledge and attitudes about erosive tooth wear among dental professionals in Saudi Arabia. This crosssectionalstudy involved 201 dental students and dentists in Saudi Arabia. Data were collected by a questionnaire adapted from a previousstudy designed to assess knowledge of and attitudes about dental erosion. SPSS software was used to analyze the data, along with t-testand ANOVA. The total knowledge score had a mean of 11.47 (standard deviation [SD]=2.14). Most participants (96.52%) know thaterosive tooth wear may lead to pain and sensitivity. However, only 36.82% know that drinking a whole bottle of soda in several sittingsrather than just one sitting decreases the risk of erosive tooth wear. The total knowledge score was not significantly different aboutgender (p=0.102), marital status (p=0.255), qualification (p=0.513), region (p=0.249), or nationality (p=0.495). The total attitude score wasmoderate and ranged from a mean of 3.21 with an SD of 1.43 for "I think prevention is better than a cure" to a mean of 4.12 with an SDof 1.48 for "I am concerned with whether or not drinks I consume are acidic." Knowledge about dental erosion among dentalprofessionals in Saudi Arabia is better than moderate, while attitudes about dental erosion were moderate. It is recommended for dentalprofessionals to have more instruction on dental erosion topics to improve their knowledge. Future studies are needed using a randomsample to achieve more generalizable results.
{"title":"Knowledge and Attitudes Toward Erosive Tooth Wear Among Dental Professionals in Saudi Arabia","authors":"Somaya Abdulrahman, Fatmah Basalama, Amjad Alsulami, Bashayer Majrashi, Bashaier Baeisa, Amal Alharbi, Ismail Abdouh","doi":"10.22376/ijlpr.2023.13.6.l325-l330","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l325-l330","url":null,"abstract":"Tooth erosion is the loss of tooth structure caused by chemical dissolution without the involvement of oral bacteria. Thisstudy aimed to assess the knowledge and attitudes about erosive tooth wear among dental professionals in Saudi Arabia. This crosssectionalstudy involved 201 dental students and dentists in Saudi Arabia. Data were collected by a questionnaire adapted from a previousstudy designed to assess knowledge of and attitudes about dental erosion. SPSS software was used to analyze the data, along with t-testand ANOVA. The total knowledge score had a mean of 11.47 (standard deviation [SD]=2.14). Most participants (96.52%) know thaterosive tooth wear may lead to pain and sensitivity. However, only 36.82% know that drinking a whole bottle of soda in several sittingsrather than just one sitting decreases the risk of erosive tooth wear. The total knowledge score was not significantly different aboutgender (p=0.102), marital status (p=0.255), qualification (p=0.513), region (p=0.249), or nationality (p=0.495). The total attitude score wasmoderate and ranged from a mean of 3.21 with an SD of 1.43 for \"I think prevention is better than a cure\" to a mean of 4.12 with an SDof 1.48 for \"I am concerned with whether or not drinks I consume are acidic.\" Knowledge about dental erosion among dentalprofessionals in Saudi Arabia is better than moderate, while attitudes about dental erosion were moderate. It is recommended for dentalprofessionals to have more instruction on dental erosion topics to improve their knowledge. Future studies are needed using a randomsample to achieve more generalizable results.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"15 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135012138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l502-l509
Dr. Gaurav Sawarkar, Dr. Shilpa Yerme, Dr. Punam Sawarkar
Frozen shoulder affects shoulder joints. Ayurveda links it to Vata-vitiated Avabhahuk. Frozen shoulders occur when aggravatedVata dries out its binding elements and constricts shoulder veins. This disorder restricts shoulder movement due to Sira constriction.Since aggravating variables cause all motor functions and joint ranges of motion, treating a frozen shoulder should focus on pacifying Vataand Kapha. The main aim of the presentcase is to assess the role of comprehensive management of a frozen shoulder in a geriatricfemale patient by using Panchakarma (purification therapy) and Shamana (palliative) in Ayurveda. And the objective is to reduce theduration of treatment and cure the medical condition with the greatest possible benefit. It is a single case study of a seventyyears oldfemale patient who has represented herself with complaints such as Pain and Stiffness in her right shoulder joint with its restrictedmovement, inability to lift a completely right hand in an upward direction, difficulty while walking due to pain in both knee joints for fourmonths. The comprehensive regime using was prescribed for purification therapy treatment (local massage with Dashmoola Oil, PatraPinda Sudation, Nasal instillation with Anutail (oil), Janu Basti (knee joint retention enema) with Sahcharadi oil, and medicated enemaregimefor 16 days. Simultaneously palliative treatment (Syrup Armex, Sinhanad Guggul, Aamvatari rasa, and Syrup Vatamritam for a consecutivemonth. After one month of follow-up, there was significant relief in clinical features of the disease, along with gross improvement in therange of motion of the affected shoulder joint. The afore-said regime based on comprehensive management in Ayurveda inducesencouraging results in a patient with frozen shoulders within a short duration. Hence it's essential due to increasing cases in day-to-daylife. So, it was concluded that the present results were due to the analgesic, anti-inflammatory & nourishing properties of Ayurvedainterventions. All the above-said treatment protocol is effective in the frozen shoulder without causing any adverse event.
{"title":"Effective Management of Frozen Shoulder: A Case Report","authors":"Dr. Gaurav Sawarkar, Dr. Shilpa Yerme, Dr. Punam Sawarkar","doi":"10.22376/ijlpr.2023.13.6.l502-l509","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l502-l509","url":null,"abstract":"Frozen shoulder affects shoulder joints. Ayurveda links it to Vata-vitiated Avabhahuk. Frozen shoulders occur when aggravatedVata dries out its binding elements and constricts shoulder veins. This disorder restricts shoulder movement due to Sira constriction.Since aggravating variables cause all motor functions and joint ranges of motion, treating a frozen shoulder should focus on pacifying Vataand Kapha. The main aim of the presentcase is to assess the role of comprehensive management of a frozen shoulder in a geriatricfemale patient by using Panchakarma (purification therapy) and Shamana (palliative) in Ayurveda. And the objective is to reduce theduration of treatment and cure the medical condition with the greatest possible benefit. It is a single case study of a seventyyears oldfemale patient who has represented herself with complaints such as Pain and Stiffness in her right shoulder joint with its restrictedmovement, inability to lift a completely right hand in an upward direction, difficulty while walking due to pain in both knee joints for fourmonths. The comprehensive regime using was prescribed for purification therapy treatment (local massage with Dashmoola Oil, PatraPinda Sudation, Nasal instillation with Anutail (oil), Janu Basti (knee joint retention enema) with Sahcharadi oil, and medicated enemaregimefor 16 days. Simultaneously palliative treatment (Syrup Armex, Sinhanad Guggul, Aamvatari rasa, and Syrup Vatamritam for a consecutivemonth. After one month of follow-up, there was significant relief in clinical features of the disease, along with gross improvement in therange of motion of the affected shoulder joint. The afore-said regime based on comprehensive management in Ayurveda inducesencouraging results in a patient with frozen shoulders within a short duration. Hence it's essential due to increasing cases in day-to-daylife. So, it was concluded that the present results were due to the analgesic, anti-inflammatory & nourishing properties of Ayurvedainterventions. All the above-said treatment protocol is effective in the frozen shoulder without causing any adverse event.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"74 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135373088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p234-p252
Ram Ajay Gupta, Aditya Shiven
Sexual or erectile dysfunction (ED) is the ineptitude to get or keep a hard penile erection. ED can have a detrimentaleffect on physical and psychological health. This review helps in understanding the detailed etiology of ED and variousapproaches for the management of ED. The occurrence and incidence of erectile dysfunction are on the rise among men.Various other factors greatly impact the progression of ED, including individual general health and physiological conditions suchas psychiatric or psychological problems, diabetes mellitus, genitourinary disease, cardiovascular disease, and chronic diseases.Erectile dysfunction occurs when the release of nitric oxide (NO) triggers the activation of the guanylate cyclase enzyme in thespongiosum and corpora cavernosa, leading to relaxation of the vascular smooth muscle and an increase in cyclic guanosinemonophosphate (cGMP) levels. This physiological process is essential for achieving and maintaining a firm penile erection. Somecommon and advanced methods, such as the physical method, sexual history, laboratory testing, apomorphine test, NPTR test,and color duplex Doppler ultrasound test, are used to diagnose erectile dysfunction. This review also focuses on emergingtreatments that address the medical need for effective ED management. This comprehensive review bridges gaps in the currentliterature, offering superior insights into ED management and improving the quality of life for individuals with ED.
{"title":"Novel Method for Identifying and Treating Erectile Dysfunction","authors":"Ram Ajay Gupta, Aditya Shiven","doi":"10.22376/ijlpr.2023.13.6.p234-p252","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p234-p252","url":null,"abstract":"Sexual or erectile dysfunction (ED) is the ineptitude to get or keep a hard penile erection. ED can have a detrimentaleffect on physical and psychological health. This review helps in understanding the detailed etiology of ED and variousapproaches for the management of ED. The occurrence and incidence of erectile dysfunction are on the rise among men.Various other factors greatly impact the progression of ED, including individual general health and physiological conditions suchas psychiatric or psychological problems, diabetes mellitus, genitourinary disease, cardiovascular disease, and chronic diseases.Erectile dysfunction occurs when the release of nitric oxide (NO) triggers the activation of the guanylate cyclase enzyme in thespongiosum and corpora cavernosa, leading to relaxation of the vascular smooth muscle and an increase in cyclic guanosinemonophosphate (cGMP) levels. This physiological process is essential for achieving and maintaining a firm penile erection. Somecommon and advanced methods, such as the physical method, sexual history, laboratory testing, apomorphine test, NPTR test,and color duplex Doppler ultrasound test, are used to diagnose erectile dysfunction. This review also focuses on emergingtreatments that address the medical need for effective ED management. This comprehensive review bridges gaps in the currentliterature, offering superior insights into ED management and improving the quality of life for individuals with ED.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"54 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135454967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p170-p191
Rajni Kaur, Hitesh Kumar Dewangan
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and damage to joints andtissues. While previous reviews exist, there still needs to be more in understanding risk factors, diagnostic methods, and treatmentoptions. This review aims to fill these gaps by providing a comprehensive overview of recent advancements in the field. To addressthe limitations of previous reviews, this article incorporates updated information on risk factors, including the influence ofenvironmental factors in industrialized nations. It highlights the significance of early RA diagnosis and emphasizes the utility ofdynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for effective disease management. Moreover, this reviewintroduces innovative nanotechnology-based treatment approaches for RA. It explores the potential of gold nanoparticles, carbonnanotubes, polymer-based nanomedicine, and nanoliposomes in targeting specific inflammatory sites and improving treatmenteffectiveness. This review aims to present an up-to-date and comprehensive analysis of RA, bridging gaps in previous literature byintroducing novel diagnostic techniques and exploring emerging treatment modalities. By synthesizing current knowledge andoutlining future research prospects, this review aims to advance the understanding and treatment of rheumatoid arthritis.Additionally, this review discusses the systemic complications associated with RA, such as rheumatoid vasculitis and Feltysyndrome. It also sheds light on the long-term consequences of untreated RA, including the potential need for joint replacementsurgery (arthroplasty) and splenectomy. By providing a comprehensive analysis of these aspects, this review aims to enhance theholistic understanding of RA and guide future research toward improved management and patient outcomes.
{"title":"Rheumatoid Arthritis: Current and Emerging Paradigms of Diagnosis and Treatment","authors":"Rajni Kaur, Hitesh Kumar Dewangan","doi":"10.22376/ijlpr.2023.13.6.p170-p191","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p170-p191","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and damage to joints andtissues. While previous reviews exist, there still needs to be more in understanding risk factors, diagnostic methods, and treatmentoptions. This review aims to fill these gaps by providing a comprehensive overview of recent advancements in the field. To addressthe limitations of previous reviews, this article incorporates updated information on risk factors, including the influence ofenvironmental factors in industrialized nations. It highlights the significance of early RA diagnosis and emphasizes the utility ofdynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for effective disease management. Moreover, this reviewintroduces innovative nanotechnology-based treatment approaches for RA. It explores the potential of gold nanoparticles, carbonnanotubes, polymer-based nanomedicine, and nanoliposomes in targeting specific inflammatory sites and improving treatmenteffectiveness. This review aims to present an up-to-date and comprehensive analysis of RA, bridging gaps in previous literature byintroducing novel diagnostic techniques and exploring emerging treatment modalities. By synthesizing current knowledge andoutlining future research prospects, this review aims to advance the understanding and treatment of rheumatoid arthritis.Additionally, this review discusses the systemic complications associated with RA, such as rheumatoid vasculitis and Feltysyndrome. It also sheds light on the long-term consequences of untreated RA, including the potential need for joint replacementsurgery (arthroplasty) and splenectomy. By providing a comprehensive analysis of these aspects, this review aims to enhance theholistic understanding of RA and guide future research toward improved management and patient outcomes.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"54 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l264-l271
Vaishnavi Ojha, Sadhana Misar Wajpeyi
Yuvan Pidika (Tarunya Pidika) is described by Acharya Sushruta under the heading "Kshudra Roga." Adolescents'faces exhibit the Shalmali thorn-like eruption caused by the vitiation of Kapha, Vata, and Rakta (Mukhadushika). Due to thesymptoms' resemblance to Acne vulgaris, it can be related. The Prakriti type of an individual determines their vulnerability tocertain diseases. Moreover, Prakriti is crucial in the development of some diseases. By evaluating the Prakriti in prediagnosedYuvanapidika participants, this observational study aimed to identify the association between the occurrence of Yuvanapidika andPrakriti. It will assist in raising awareness of preventive actions among those belonging to a particular Prakriti whereYuvanapidika is more common. According to the inclusion criteria, the individuals with Tarunya pidika were chosen for thestudy. Prakriti was evaluated utilizing an online Prakriti Parikshana app and a personal interview based on previously designed,validated questionnaires. Younger age groups (18 to 22) had a higher prevalence of Yuvanapidika, and more cases werediscovered in Pitta-dominant and Kapha-predominant Prakriti. Aggravated Pitta affects the blood or Rakta dhatu. Thecontaminated blood affects the epidermis and encourages overactive sebaceous gland oil production. The Kapha quality is sticky.Aggravated Kapha makes the oil that the skin's sebaceous glands secrete stickier. Hence, developing thick sebaceous plugs in theskin's pores and hair follicles leads to acne. Since Kaphapittaja Prakriti contained the highest concentration of Yuvanapidika, itcan be concluded that there is an association between Prakriti and the occurrence of Yuvanapidika.
{"title":"Association Between Incidence of Tarunya Pidika and Prakriti in Students - An Observational Study","authors":"Vaishnavi Ojha, Sadhana Misar Wajpeyi","doi":"10.22376/ijlpr.2023.13.6.l264-l271","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l264-l271","url":null,"abstract":"Yuvan Pidika (Tarunya Pidika) is described by Acharya Sushruta under the heading \"Kshudra Roga.\" Adolescents'faces exhibit the Shalmali thorn-like eruption caused by the vitiation of Kapha, Vata, and Rakta (Mukhadushika). Due to thesymptoms' resemblance to Acne vulgaris, it can be related. The Prakriti type of an individual determines their vulnerability tocertain diseases. Moreover, Prakriti is crucial in the development of some diseases. By evaluating the Prakriti in prediagnosedYuvanapidika participants, this observational study aimed to identify the association between the occurrence of Yuvanapidika andPrakriti. It will assist in raising awareness of preventive actions among those belonging to a particular Prakriti whereYuvanapidika is more common. According to the inclusion criteria, the individuals with Tarunya pidika were chosen for thestudy. Prakriti was evaluated utilizing an online Prakriti Parikshana app and a personal interview based on previously designed,validated questionnaires. Younger age groups (18 to 22) had a higher prevalence of Yuvanapidika, and more cases werediscovered in Pitta-dominant and Kapha-predominant Prakriti. Aggravated Pitta affects the blood or Rakta dhatu. Thecontaminated blood affects the epidermis and encourages overactive sebaceous gland oil production. The Kapha quality is sticky.Aggravated Kapha makes the oil that the skin's sebaceous glands secrete stickier. Hence, developing thick sebaceous plugs in theskin's pores and hair follicles leads to acne. Since Kaphapittaja Prakriti contained the highest concentration of Yuvanapidika, itcan be concluded that there is an association between Prakriti and the occurrence of Yuvanapidika.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"83 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l258-l263
K. Kirupa, S.M. Divyamary, R. Nithya Nisha, K Saraswath, , D.P. Kaviya, B. Aishwarya, N. Nimisha Lakshmi, K. Swetha
This study was conducted to improve the patient's oral function, especially dry mouth (xerostomia) and infection. The aim of this study is to analyse the effectiveness of transcutaneous electrical nerve stimulation vs. oral exercise in reducing hypo salivation among type II diabetic patients over the submandibular glands. The secretion of saliva is critical for oral health, digestion, prevention of infections, and the healing process. Hypo salivation is defined as a decrease in saliva in the mouth. It is the most common type II diabetic problem among adults and older people. It is estimated to occur in 10 of every 35 adults. Because of hypo salivation, Type II diabetic adults may experience infection, cavities, soreness, ulcers, a decrease in taste sensation, and difficulty in water balance. Hypo salivation leads to many complications that make the condition of the diabetic patient even worse. Hence, there is a wide need for treatment techniques to be searched for, and they must be applicable to all communities. There are various therapies to improve the salivary rate, but there is a need to analyse the technique that gives better outcomes with a short intervention with easy accessibility. The materials and method of this study follow a simple method and are evidenced with a noninvasive diagnostic tool. Saliometry by the low-spitting method was used to measure the salivary flow rate. The methodology was a comparative study design with a pre-post-test. Samples were selected from 40 volunteers based on inclusion criteria. Group A: Transcutaneous Electrical Nerve Stimulation, 8 sessions, 20 minutes each, twice a week for 4 weeks. Group B: Oral exercise, 16 sessions, 2 minutes each, in 3 sets for 4 weeks. At the end of 30 days of sessions, the salivary flow rate has increased from 0.36 to 1.03 ml/min and the SD from 0.12 to 0.91 for Group A, and from 0.34 to 0.56 ml/min and the SD from 0.2 to 0.4. The result concludes that both groups showed improvement, while group A, which received transcutaneous electrical nerve stimulation, was comparatively better than group B, which received oral exercise
{"title":"Effectiveness of Transcutaneous Electrical Nerve Stimulations Oral Exercise in Hypo Salivation Among Type II Diabetic Patients Over Submandibular Glands","authors":"K. Kirupa, S.M. Divyamary, R. Nithya Nisha, K Saraswath, , D.P. Kaviya, B. Aishwarya, N. Nimisha Lakshmi, K. Swetha","doi":"10.22376/ijlpr.2023.13.6.l258-l263","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l258-l263","url":null,"abstract":"This study was conducted to improve the patient's oral function, especially dry mouth (xerostomia) and infection. The aim of this study is to analyse the effectiveness of transcutaneous electrical nerve stimulation vs. oral exercise in reducing hypo salivation among type II diabetic patients over the submandibular glands. The secretion of saliva is critical for oral health, digestion, prevention of infections, and the healing process. Hypo salivation is defined as a decrease in saliva in the mouth. It is the most common type II diabetic problem among adults and older people. It is estimated to occur in 10 of every 35 adults. Because of hypo salivation, Type II diabetic adults may experience infection, cavities, soreness, ulcers, a decrease in taste sensation, and difficulty in water balance. Hypo salivation leads to many complications that make the condition of the diabetic patient even worse. Hence, there is a wide need for treatment techniques to be searched for, and they must be applicable to all communities. There are various therapies to improve the salivary rate, but there is a need to analyse the technique that gives better outcomes with a short intervention with easy accessibility. The materials and method of this study follow a simple method and are evidenced with a noninvasive diagnostic tool. Saliometry by the low-spitting method was used to measure the salivary flow rate. The methodology was a comparative study design with a pre-post-test. Samples were selected from 40 volunteers based on inclusion criteria. Group A: Transcutaneous Electrical Nerve Stimulation, 8 sessions, 20 minutes each, twice a week for 4 weeks. Group B: Oral exercise, 16 sessions, 2 minutes each, in 3 sets for 4 weeks. At the end of 30 days of sessions, the salivary flow rate has increased from 0.36 to 1.03 ml/min and the SD from 0.12 to 0.91 for Group A, and from 0.34 to 0.56 ml/min and the SD from 0.2 to 0.4. The result concludes that both groups showed improvement, while group A, which received transcutaneous electrical nerve stimulation, was comparatively better than group B, which received oral exercise","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"73 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136306544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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