Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l394-l402
Dr Maltee Patel, Dr Dnyanesh Joshi, Dr Manish Kumar Patel
: Cosmetics are practical items that are widely used across the world to preserve and enhance the look of the face and other body parts, such as the lips, hands, fingers, eyes, and hair, among others. The personal care industry is currently more concentrated on herbal cosmetics as nowadays it is fast growing segment with a vast scope of various expansions in coming years. Herbal cosmetics are the preparations that represent cosmetics associated with active bio - ingredients, nutraceuticals, or pharmaceuticals. The use of bioactive phytochemicals from various botanicals has a dual function: they are used as cosmetics to care for the body and its parts, and the botanical components impact the skin's biological processes. Identifying the phytochemicals for skin and body care products is greatly aided by our historical understanding of the utilization of plant riches as documented in the Ayurveda, Siddha, Unani, and Tibetan systems of medicine. The development of Nobel cosmeceuticals for skin & body care illnesses will require the necessary efforts to associate current cosmetology with bioactive components based on our traditional system of medicine. Additionally, it significantly polluted the environment and disrupted our ecosystem. To enhance people's health and the quality of their lives and address the limitations of the allopathic system, both contemporary and conventional approaches must be used in addition to it. This has resulted in a rise in the use of herbal medications, cosmetics, neutraceuticals, and natural dyes. The aim of this review is to demonstrate the preventive methods of Ayurveda for skin and hair care in the contemporary period and to describe, based on a literature review, the relationship between Ayurveda and cosmetics. The knowledge of medicinal plants used by the people is well-known in its culture and tradition. The association between Ayurveda and cosmeceuticals has also been reviewed in this article.
{"title":"Ayurveda's Contemporary Preventative Approach to Skin and Hair CareA Review Study","authors":"Dr Maltee Patel, Dr Dnyanesh Joshi, Dr Manish Kumar Patel","doi":"10.22376/ijlpr.2023.13.6.l394-l402","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l394-l402","url":null,"abstract":": Cosmetics are practical items that are widely used across the world to preserve and enhance the look of the face and other body parts, such as the lips, hands, fingers, eyes, and hair, among others. The personal care industry is currently more concentrated on herbal cosmetics as nowadays it is fast growing segment with a vast scope of various expansions in coming years. Herbal cosmetics are the preparations that represent cosmetics associated with active bio - ingredients, nutraceuticals, or pharmaceuticals. The use of bioactive phytochemicals from various botanicals has a dual function: they are used as cosmetics to care for the body and its parts, and the botanical components impact the skin's biological processes. Identifying the phytochemicals for skin and body care products is greatly aided by our historical understanding of the utilization of plant riches as documented in the Ayurveda, Siddha, Unani, and Tibetan systems of medicine. The development of Nobel cosmeceuticals for skin & body care illnesses will require the necessary efforts to associate current cosmetology with bioactive components based on our traditional system of medicine. Additionally, it significantly polluted the environment and disrupted our ecosystem. To enhance people's health and the quality of their lives and address the limitations of the allopathic system, both contemporary and conventional approaches must be used in addition to it. This has resulted in a rise in the use of herbal medications, cosmetics, neutraceuticals, and natural dyes. The aim of this review is to demonstrate the preventive methods of Ayurveda for skin and hair care in the contemporary period and to describe, based on a literature review, the relationship between Ayurveda and cosmetics. The knowledge of medicinal plants used by the people is well-known in its culture and tradition. The association between Ayurveda and cosmeceuticals has also been reviewed in this article.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"387 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p344-p354
Rima Kumari Prajapati, Sujatha P. Muchalambe, Hindustan Abdul Ahad, Saurabh Kumar Shukla, Pushpa Sahani
The present research work aims to formulate and evaluate novel sustained-discharge floating tablets of verapamilhydrochloride (VPH) which is used for the treatment of hypertension. We aim to use a direct compression technique to formulatethe floating tablets. The characterization of the formulation of VPH was carried out by employing FT-IR and DSC studies, whichshowed that there was no chemical interaction between the drug and polymers, such as HPMC K100M, chitosan, and sodiumalginate. The tablets are designed to have good in-vitro buoyancy, and they remain afloat in the dissolution medium. The bestformulation (F7) is chosen based on its maximum drug discharge (91.91±2.25%) and drug content (97.20±2.71%) over 12h. Thedischarge kinetics of the drug from the tablets are analyzed using various mathematical models, such as zero order, first order,Higuchi, and Korsmeyer's equations. These models help explain and predict drug discharge behavior over time. The studyconcludes that a proper balance between the sustained-release polymer and the gas-forming agent is essential for efficient in-vitrobuoyancy and sustained drug discharge. Formulation F7, which utilized sodium alginate, appears to be the most promising in termsof drug discharge and content.
{"title":"Formulation and in vitro Evaluation of Verapamil Hydrochloride Floating Tablets","authors":"Rima Kumari Prajapati, Sujatha P. Muchalambe, Hindustan Abdul Ahad, Saurabh Kumar Shukla, Pushpa Sahani","doi":"10.22376/ijlpr.2023.13.6.p344-p354","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p344-p354","url":null,"abstract":"The present research work aims to formulate and evaluate novel sustained-discharge floating tablets of verapamilhydrochloride (VPH) which is used for the treatment of hypertension. We aim to use a direct compression technique to formulatethe floating tablets. The characterization of the formulation of VPH was carried out by employing FT-IR and DSC studies, whichshowed that there was no chemical interaction between the drug and polymers, such as HPMC K100M, chitosan, and sodiumalginate. The tablets are designed to have good in-vitro buoyancy, and they remain afloat in the dissolution medium. The bestformulation (F7) is chosen based on its maximum drug discharge (91.91±2.25%) and drug content (97.20±2.71%) over 12h. Thedischarge kinetics of the drug from the tablets are analyzed using various mathematical models, such as zero order, first order,Higuchi, and Korsmeyer's equations. These models help explain and predict drug discharge behavior over time. The studyconcludes that a proper balance between the sustained-release polymer and the gas-forming agent is essential for efficient in-vitrobuoyancy and sustained drug discharge. Formulation F7, which utilized sodium alginate, appears to be the most promising in termsof drug discharge and content.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"9 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l45-l50
Dr.Logeswari B.M, Dr.Vatsala Shahi
In pregnancy, venous thromboembolism (VTE) remains a leading cause of direct maternal mortality. It is approximatelyfive times more common in pregnant women, with an incidence of 0.5-2 in 1000. The highest risk of deep venous thrombosis(DVT) leading to pulmonary embolism (PE) is during the postnatal period, especially after a cesarean section. A clinician who doesnot treat pregnant women regularly may not routinely identify pregnancy-specific risk factors for VTE. In patients with DVT,treatment with anticoagulation is associated with a high risk of bleeding during the immediate postpartum state, and patients dowell with monitored anticoagulation and proper supportive treatment, as described in this case report. We are reporting a caseof a 20-year-old primigravida who presented with labor pains at 39 (+6) weeks of gestation at Sree Balaji Medical College andHospital, Chrompet, Chennai. The patient had no comorbidities and did not report any past or family history of VTE. An emergencycesarean section was performed due to fetal distress, and on the first postoperative day, she developed swelling pain andtenderness in the left lower limb. Color Doppler ultrasound showed left anterior tibial vein thrombosis, following whichanticoagulant therapy was started with low molecular weight heparin. The patient was closely monitored for signs of bleeding orPE and was eventually discharged on oral anticoagulation. In conclusion, all women should be assessed for the risk factors of DVTduring the antenatal period, and early ambulation in the postoperative period is crucial to prevent such deadly complications.
{"title":"Case Report on Challenging Deep Vein Thrombosis","authors":"Dr.Logeswari B.M, Dr.Vatsala Shahi","doi":"10.22376/ijlpr.2023.13.6.l45-l50","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l45-l50","url":null,"abstract":"In pregnancy, venous thromboembolism (VTE) remains a leading cause of direct maternal mortality. It is approximatelyfive times more common in pregnant women, with an incidence of 0.5-2 in 1000. The highest risk of deep venous thrombosis(DVT) leading to pulmonary embolism (PE) is during the postnatal period, especially after a cesarean section. A clinician who doesnot treat pregnant women regularly may not routinely identify pregnancy-specific risk factors for VTE. In patients with DVT,treatment with anticoagulation is associated with a high risk of bleeding during the immediate postpartum state, and patients dowell with monitored anticoagulation and proper supportive treatment, as described in this case report. We are reporting a caseof a 20-year-old primigravida who presented with labor pains at 39 (+6) weeks of gestation at Sree Balaji Medical College andHospital, Chrompet, Chennai. The patient had no comorbidities and did not report any past or family history of VTE. An emergencycesarean section was performed due to fetal distress, and on the first postoperative day, she developed swelling pain andtenderness in the left lower limb. Color Doppler ultrasound showed left anterior tibial vein thrombosis, following whichanticoagulant therapy was started with low molecular weight heparin. The patient was closely monitored for signs of bleeding orPE and was eventually discharged on oral anticoagulation. In conclusion, all women should be assessed for the risk factors of DVTduring the antenatal period, and early ambulation in the postoperative period is crucial to prevent such deadly complications.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"84 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l462-l467
Dr. Subha. L, Dr. DhilsathRaseena. N, Dr G. Amruthaa
Scrub Typhus, a vector-borne and zoonotic disease by Orientia tsutsugamushi, is one of the causes of acute febrileillness in India. In endemic regions where Scrub Typhus is prevalent, healthcare providers should keep an eye out and be verysuspicious about this disease, especially when encountering patients with acute febrile illness and exposure to mite-infested areas.Prompt recognition and appropriate diagnostic testing, such as serological assays or molecular methods, are essential for accuratediagnosis. Once diagnosed, treatment with appropriate antibiotics, such as doxycycline or azithromycin, can effectively manageScrub Typhus and prevent complications. Early initiation of treatment is crucial to reduce the chance of severe disease and potentialmortality. This case report highlights the importance of considering Scrub Typhus as a potential differential diagnosis in lid infectionsand acute febrile illnesses, particularly in areas where the disease is endemic. Healthcare providers should be aware of the diverseclinical presentations and remain vigilant to ensure timely and accurate diagnosis, leading to appropriate management and improvedpatient outcomes. Public health efforts should also focus on increasing awareness about Scrub Typhus, its prevention, and earlydetection to minimize the burden of this often underdiagnosed disease. In this case report, we presented a child with febrile illnessand unilateral lid swelling misdiagnosed as stye. The presence of eschar prompted an investigation of Scrub typhus, which waspositive. This case is reported as the lid is an unusual site for eschar formation. To reiterate, scrub typhus should be considered adifferential diagnosis in lid infections and acute febrile illness, particularly in endemic areas.
{"title":"Mite Bite Underlying A Lid Swelling - A Rare Presentation Of Scrub Typhus","authors":"Dr. Subha. L, Dr. DhilsathRaseena. N, Dr G. Amruthaa","doi":"10.22376/ijlpr.2023.13.6.l462-l467","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l462-l467","url":null,"abstract":"Scrub Typhus, a vector-borne and zoonotic disease by Orientia tsutsugamushi, is one of the causes of acute febrileillness in India. In endemic regions where Scrub Typhus is prevalent, healthcare providers should keep an eye out and be verysuspicious about this disease, especially when encountering patients with acute febrile illness and exposure to mite-infested areas.Prompt recognition and appropriate diagnostic testing, such as serological assays or molecular methods, are essential for accuratediagnosis. Once diagnosed, treatment with appropriate antibiotics, such as doxycycline or azithromycin, can effectively manageScrub Typhus and prevent complications. Early initiation of treatment is crucial to reduce the chance of severe disease and potentialmortality. This case report highlights the importance of considering Scrub Typhus as a potential differential diagnosis in lid infectionsand acute febrile illnesses, particularly in areas where the disease is endemic. Healthcare providers should be aware of the diverseclinical presentations and remain vigilant to ensure timely and accurate diagnosis, leading to appropriate management and improvedpatient outcomes. Public health efforts should also focus on increasing awareness about Scrub Typhus, its prevention, and earlydetection to minimize the burden of this often underdiagnosed disease. In this case report, we presented a child with febrile illnessand unilateral lid swelling misdiagnosed as stye. The presence of eschar prompted an investigation of Scrub typhus, which waspositive. This case is reported as the lid is an unusual site for eschar formation. To reiterate, scrub typhus should be considered adifferential diagnosis in lid infections and acute febrile illness, particularly in endemic areas.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l436-l448
N. Amudha, R. Magalingam, K. Selvam, V. Ambikapathy, P. Prakash
There are numerous therapeutic uses for medicinal plants in treating and managing numerous diseases. Traditional medicinal plantswere mostly needed in the current scenario. The world's warmer and wetlands regions are home to the medicinal herb Bacopa monnieri (L.).It has been utilized for ages in Ayurvedic systems. The Bacopa monnieri was one of the traditional medicinal plants. These are commonlycalled "Brahmi," and the Tamil vernacular name is "Neerbrahmmi." It is easy to cultivate and grow in all seasons. These peculiar activeingredients, also known as memory enhancement and phytoconstituents were enriched in this medicinal plant. The present study focused onanalyzing phytoconstituents and the antimicrobial activity of Bacopa monnieri leaves. The efficacy of phytoconstituents on the antimicrobialactivities concerning minimum inhibitory concentrations was performed with different polar and non-polar solvents of the respective plant.The phytoconstituents such as alkaloids, amino acids, coumarins, flavonoids, glycosides, phenols, phlobatannins, quinones, reducing sugars,saponins, steroids, tannins, and terpenoids were recorded, respectively. Antibacterial activity performed with following human clinicalbacteria like Clostridium butyricum, Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae, and the antifungal activity against humanclinical such as Aspergillus flavus, A.niger, Aspergillus sp., and Penicillium sp. were determined. Among the two solvent extractions, the aqueousextract showed a more significant result than the benzene extract. According to the MIC, the antimicrobial properties of B.monnieriwithdifferent extracts were analyzed. The very minimum concentration has shown better inhibitions against microbes. The present study exploredthe antimicrobial properties of human clinical pathogens. So, the B.monnieriaqueous extract of leaves was suggested for the treatment ofmicrobial infections.
{"title":"Analysis of Phytoconstituents and Antimicrobial Properties of Bacopa monnieri (L.) Against Clinical Pathogen","authors":"N. Amudha, R. Magalingam, K. Selvam, V. Ambikapathy, P. Prakash","doi":"10.22376/ijlpr.2023.13.6.l436-l448","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l436-l448","url":null,"abstract":"There are numerous therapeutic uses for medicinal plants in treating and managing numerous diseases. Traditional medicinal plantswere mostly needed in the current scenario. The world's warmer and wetlands regions are home to the medicinal herb Bacopa monnieri (L.).It has been utilized for ages in Ayurvedic systems. The Bacopa monnieri was one of the traditional medicinal plants. These are commonlycalled \"Brahmi,\" and the Tamil vernacular name is \"Neerbrahmmi.\" It is easy to cultivate and grow in all seasons. These peculiar activeingredients, also known as memory enhancement and phytoconstituents were enriched in this medicinal plant. The present study focused onanalyzing phytoconstituents and the antimicrobial activity of Bacopa monnieri leaves. The efficacy of phytoconstituents on the antimicrobialactivities concerning minimum inhibitory concentrations was performed with different polar and non-polar solvents of the respective plant.The phytoconstituents such as alkaloids, amino acids, coumarins, flavonoids, glycosides, phenols, phlobatannins, quinones, reducing sugars,saponins, steroids, tannins, and terpenoids were recorded, respectively. Antibacterial activity performed with following human clinicalbacteria like Clostridium butyricum, Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae, and the antifungal activity against humanclinical such as Aspergillus flavus, A.niger, Aspergillus sp., and Penicillium sp. were determined. Among the two solvent extractions, the aqueousextract showed a more significant result than the benzene extract. According to the MIC, the antimicrobial properties of B.monnieriwithdifferent extracts were analyzed. The very minimum concentration has shown better inhibitions against microbes. The present study exploredthe antimicrobial properties of human clinical pathogens. So, the B.monnieriaqueous extract of leaves was suggested for the treatment ofmicrobial infections.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"86 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135456275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l205-l210
Dr Swapnali Yewale, Dr Prasad Yewale
Ayurveda is an eternal science. Among all the vise concepts of Ayurveda, Trayaupsthambha has prime importance as itconsists of three pillars that are Ahara(Diet), Nidra(Sleep), and Brahmacharya (Celibacy). The longevity and happiness of lifedepend upon these three pillars. Each one has its importance; among them, Aharaachieved first position in Trayaupsthambha,which denotes its prime importance in Trayaupsthambha. Hence we must know the Ahara (diet) described in Ayurveda.Consuming a healthy diet in the right way can lead to good health; however, eating food that isn't wholesome can make you sick.Ahara gives the body power, radiance, and Oja; it is essential for longevity and increases mental fortitude. Our ancient seerdescribes some rules regarding diet that every person should follow. If not, then the most beneficial object Ahara will turn into amost harmful object, which can cause various diseases. The healthy physical body and mind together are responsible for health.Our ancient seer, in their commentaries, proves that Ayurveda helps in keeping the equilibrium of all physiological functions ofSharir and Manas via proper Ahara. This article aims to study the importance of the ahara in today's life. To achieve the goal of ahealthy life, the Ahara plays a vital role. This article aims to collect and analyze the literature review of the Sahara andunderstand the dietic rules explained in Ayurveda. This article discussed the significance of Ahara and diseases caused by pooreating habits. If Ahara is not consumed properly, numerous disorders, including the effects of Apathya-Ahara, may be noticed.
{"title":"Importance of Ahara in Today’s Life with Special Reference to Ayurveda.","authors":"Dr Swapnali Yewale, Dr Prasad Yewale","doi":"10.22376/ijlpr.2023.13.6.l205-l210","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l205-l210","url":null,"abstract":"Ayurveda is an eternal science. Among all the vise concepts of Ayurveda, Trayaupsthambha has prime importance as itconsists of three pillars that are Ahara(Diet), Nidra(Sleep), and Brahmacharya (Celibacy). The longevity and happiness of lifedepend upon these three pillars. Each one has its importance; among them, Aharaachieved first position in Trayaupsthambha,which denotes its prime importance in Trayaupsthambha. Hence we must know the Ahara (diet) described in Ayurveda.Consuming a healthy diet in the right way can lead to good health; however, eating food that isn't wholesome can make you sick.Ahara gives the body power, radiance, and Oja; it is essential for longevity and increases mental fortitude. Our ancient seerdescribes some rules regarding diet that every person should follow. If not, then the most beneficial object Ahara will turn into amost harmful object, which can cause various diseases. The healthy physical body and mind together are responsible for health.Our ancient seer, in their commentaries, proves that Ayurveda helps in keeping the equilibrium of all physiological functions ofSharir and Manas via proper Ahara. This article aims to study the importance of the ahara in today's life. To achieve the goal of ahealthy life, the Ahara plays a vital role. This article aims to collect and analyze the literature review of the Sahara andunderstand the dietic rules explained in Ayurveda. This article discussed the significance of Ahara and diseases caused by pooreating habits. If Ahara is not consumed properly, numerous disorders, including the effects of Apathya-Ahara, may be noticed.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"41 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.p37-p50
Mr. Ganesh B. Nigade, Dr. Meenakshi N. Deodhar, Dr. Rajashree S. Chavan
Amalaki, i.e., Indian gooseberry, is a medicinal plant with rejuvenator, anti-aging, and adaptogenic properties. It has a significant amountof ascorbic acid, an essential nutrient for various biochemical and physiological processes in the body. Amalaki is used in different ayurvedicformulations like churna, juice, rasayan, chyavanaprash, dhatri lauha, dhatryadi ghrita, and Triphala churna. Even so, more work was needed toestablish quality control standards for Amalaki formulations. This is because the plant is considered safe, and there are few reports of adverseeffects. Therefore, there needs to be more incentive to conduct rigorous studies on the safety and efficacy of Amalaki formulations. Despite thislack of research, Amalaki is still widely used with few reported side effects, making it an attractive option for those seeking natural remedies. In thepresent study, the phytochemical screening & physical evaluation were carried out of Amalaki formulations. The study includes determiningorganoleptic characters, moisture contents, ash, extractive values, etc. Marketed amalaki formulations were extracted in the microwave usingsolvent methanol: water (70:30). UV-Vis spectrophotometer was used for quantitative phytochemical evaluation of extracts of amalakiformulations. Alkaloids, flavonoids, carbohydrates, phenols, and tannins were found in the qualitative phytochemical evaluation of amalakiformulations. Total phenolic, flavonoid, tannin, sugar, and reducing sugar content of extract of Amalaki formulation AMK I & AMK II was found tobe 114.11±0.035mg GAE/g & 116.12 ± 0.020 mg GAE/g, 29.15 ± 0.0029 mg QE/g & 29.75 ± 0.0020 mg QE/g, 4.50 ± 0.0085 mg CE/g & 4.70 ±0.0079 mg CE/g, 7.34 ± 0.0034 mg Glu/g & 7.44 ± 0.0043 mg Glu/g & 3.41 ± 0.0035 mg Glu/g & 3.65 ± 0.0031 mg Glu/g, respectively. The FT-IRspectra of the extract of amalaki formulations were recorded in the region 4000–400 cm−1. They confirmed the presence of the O-H, aromatic CHstarch, C=C & C-O groups. The rutin, ascorbic acid, gallic acid, & kaempferol concentrations in the extracts of amalaki formulation wereeffectively estimated using the HPTLC method for marketed amalaki formulations.
{"title":"Phytochemical Screening, Spectroscopic & HPTLC Evaluation of Amalaki Formulation","authors":"Mr. Ganesh B. Nigade, Dr. Meenakshi N. Deodhar, Dr. Rajashree S. Chavan","doi":"10.22376/ijlpr.2023.13.6.p37-p50","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.p37-p50","url":null,"abstract":"Amalaki, i.e., Indian gooseberry, is a medicinal plant with rejuvenator, anti-aging, and adaptogenic properties. It has a significant amountof ascorbic acid, an essential nutrient for various biochemical and physiological processes in the body. Amalaki is used in different ayurvedicformulations like churna, juice, rasayan, chyavanaprash, dhatri lauha, dhatryadi ghrita, and Triphala churna. Even so, more work was needed toestablish quality control standards for Amalaki formulations. This is because the plant is considered safe, and there are few reports of adverseeffects. Therefore, there needs to be more incentive to conduct rigorous studies on the safety and efficacy of Amalaki formulations. Despite thislack of research, Amalaki is still widely used with few reported side effects, making it an attractive option for those seeking natural remedies. In thepresent study, the phytochemical screening & physical evaluation were carried out of Amalaki formulations. The study includes determiningorganoleptic characters, moisture contents, ash, extractive values, etc. Marketed amalaki formulations were extracted in the microwave usingsolvent methanol: water (70:30). UV-Vis spectrophotometer was used for quantitative phytochemical evaluation of extracts of amalakiformulations. Alkaloids, flavonoids, carbohydrates, phenols, and tannins were found in the qualitative phytochemical evaluation of amalakiformulations. Total phenolic, flavonoid, tannin, sugar, and reducing sugar content of extract of Amalaki formulation AMK I & AMK II was found tobe 114.11±0.035mg GAE/g & 116.12 ± 0.020 mg GAE/g, 29.15 ± 0.0029 mg QE/g & 29.75 ± 0.0020 mg QE/g, 4.50 ± 0.0085 mg CE/g & 4.70 ±0.0079 mg CE/g, 7.34 ± 0.0034 mg Glu/g & 7.44 ± 0.0043 mg Glu/g & 3.41 ± 0.0035 mg Glu/g & 3.65 ± 0.0031 mg Glu/g, respectively. The FT-IRspectra of the extract of amalaki formulations were recorded in the region 4000–400 cm−1. They confirmed the presence of the O-H, aromatic CHstarch, C=C & C-O groups. The rutin, ascorbic acid, gallic acid, & kaempferol concentrations in the extracts of amalaki formulation wereeffectively estimated using the HPTLC method for marketed amalaki formulations.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"2 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l241-l245
Dr. Simran D. Badki, Dr. Vidya K. Lohe, Dr. Rahul Bhowate, Dr. Suwarna Dangore, Dr. Mrunal Meshram, Dr.Pragati Bhargava
Oral sub-mucous fibrosis is a premalignant condition recently recognized as "areca nut-induced oral fibrosis." It is "achronic disease which is irreversible, affecting oral and systemic health of patients." However, Areca nut or betel nut is the primaryetiologic reason for Oral Submucous fibrosis (OSMF); other factors like excess chilies intake, nutritional deficiencies, andimmunological factors are also considered causative agents for the disease. It causes inflammation and fibrosis of the submucosaltissues causing trismus and rigid oral mucosa. The treatment for this disorder includes numerous conservative, medicinal, andsurgical management; however, no treatment modality has been proven to be a standard treatment option. Herbal modalities areseen to be more effective in OSMF treatment. Unfortunately, the literature on the management of OSMF cannot do justice to allthe treatment modalities at one stop. The new trends and treatment modalities for OSMF keep adding up from time to time, andyet formulating the perfect treatment protocol for OSMF management is still challenging for dental clinicians due to themultifactorial etiology, complexity of the disease, and changing trends in treatment. The present review aimed to enlighten cliniciansabout the current disease scenario and tried to include all the latest treatment modalities. The objectives are to review and assessthe existing situation of this disease with a brief on the efficacy of different available treatment modalities used to help dentalphysicians formulate a treatment protocol with knowing the proper effects, advantages, and disadvantages of each modality andenlightening the potential future treatment options for OSMF.
{"title":"Current Management Strategies in Oral Submucous Fibrosis","authors":"Dr. Simran D. Badki, Dr. Vidya K. Lohe, Dr. Rahul Bhowate, Dr. Suwarna Dangore, Dr. Mrunal Meshram, Dr.Pragati Bhargava","doi":"10.22376/ijlpr.2023.13.6.l241-l245","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l241-l245","url":null,"abstract":"Oral sub-mucous fibrosis is a premalignant condition recently recognized as \"areca nut-induced oral fibrosis.\" It is \"achronic disease which is irreversible, affecting oral and systemic health of patients.\" However, Areca nut or betel nut is the primaryetiologic reason for Oral Submucous fibrosis (OSMF); other factors like excess chilies intake, nutritional deficiencies, andimmunological factors are also considered causative agents for the disease. It causes inflammation and fibrosis of the submucosaltissues causing trismus and rigid oral mucosa. The treatment for this disorder includes numerous conservative, medicinal, andsurgical management; however, no treatment modality has been proven to be a standard treatment option. Herbal modalities areseen to be more effective in OSMF treatment. Unfortunately, the literature on the management of OSMF cannot do justice to allthe treatment modalities at one stop. The new trends and treatment modalities for OSMF keep adding up from time to time, andyet formulating the perfect treatment protocol for OSMF management is still challenging for dental clinicians due to themultifactorial etiology, complexity of the disease, and changing trends in treatment. The present review aimed to enlighten cliniciansabout the current disease scenario and tried to include all the latest treatment modalities. The objectives are to review and assessthe existing situation of this disease with a brief on the efficacy of different available treatment modalities used to help dentalphysicians formulate a treatment protocol with knowing the proper effects, advantages, and disadvantages of each modality andenlightening the potential future treatment options for OSMF.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"91 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135163154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l280-l285
Dr. Nithya .R, Dr.ch. Yamini Uma Deepthi
Ovarian hyperstimulation syndrome is an iatrogenic medical complication unique to stimulatory infertility treatment.Characteristics of the syndrome include cystic ovarian enlargement, increased capillary permeability resulting in extravascularfluid accumulation, and intravascular volume depletion. It is a self-limiting disease in mild cases but can cause renal failure,hydrothorax, and respiratory distress that can cause mortality in severe cases. In this case, we aimed to report moderateovarian hyperstimulation (grade 3) syndrome, ultimately resulting in ovarian torsion and salphingo oophorectomy. Casepresentation-A 29-year-old female known case of polycystic ovarian syndrome underwent ovulation induction 22 days later. Shepresented to our hospital with severe abdominal pain, abdominal distension, and vomiting. She was admitted and diagnosed withGrade 3 Ovarian hyperstimulation syndrome medical management, given the patient got better symptomatically. 10 days later,she presented in casualty with abdominal pain and was diagnosed with right ovarian torsion and right salphingo oophorectomydone. Conclusion: We should rule out risk factors for ovarian Hyperstimulation syndrome before treating any infertility patient.Patients with ovarian hyperstimulation syndrome must be identified early and referred urgently to a tertiary care hospital.Ovarian hyperstimulation syndrome can result in serious morbidity and mortality if left untreated
{"title":"Iatrogenic Ovarian Hyperstimulation Syndrome in Late Luteal Phase – A Rare Case Report","authors":"Dr. Nithya .R, Dr.ch. Yamini Uma Deepthi","doi":"10.22376/ijlpr.2023.13.6.l280-l285","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l280-l285","url":null,"abstract":"Ovarian hyperstimulation syndrome is an iatrogenic medical complication unique to stimulatory infertility treatment.Characteristics of the syndrome include cystic ovarian enlargement, increased capillary permeability resulting in extravascularfluid accumulation, and intravascular volume depletion. It is a self-limiting disease in mild cases but can cause renal failure,hydrothorax, and respiratory distress that can cause mortality in severe cases. In this case, we aimed to report moderateovarian hyperstimulation (grade 3) syndrome, ultimately resulting in ovarian torsion and salphingo oophorectomy. Casepresentation-A 29-year-old female known case of polycystic ovarian syndrome underwent ovulation induction 22 days later. Shepresented to our hospital with severe abdominal pain, abdominal distension, and vomiting. She was admitted and diagnosed withGrade 3 Ovarian hyperstimulation syndrome medical management, given the patient got better symptomatically. 10 days later,she presented in casualty with abdominal pain and was diagnosed with right ovarian torsion and right salphingo oophorectomydone. Conclusion: We should rule out risk factors for ovarian Hyperstimulation syndrome before treating any infertility patient.Patients with ovarian hyperstimulation syndrome must be identified early and referred urgently to a tertiary care hospital.Ovarian hyperstimulation syndrome can result in serious morbidity and mortality if left untreated","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.22376/ijlpr.2023.13.6.l57-l71
Pravith P Warrier, Madhavi R Badole
Curcuma angustifolia Roxb., a rhizomatous herb, belongs to the Zingiberaceae family of plants. The species is rich innutrients and is used mostly as a source of starch for Indian dishes and medicines. The published research articles for themeasurable estimation of components in Curcuma angustifolia Roxb. rhizomes are very scarce. The present study aimed to developa quantitative analysis method for estimating the constituents in the methanolic extract of Curcuma angustifolia Roxb. rhizome andto investigate its biological activity. Within the context of this challenge, the current work is a unique effort that recommends ahigh-performance liquid chromatography (HPLC) method for estimating curcuminoids, namely curcumin, demethoxycurcumin,and bis-demethoxycurcumin, present in the methanolic extract of Curcuma angustifolia Roxb. rhizome. A reverse-phase HPLCmethod was developed to estimate curcuminoids in the extract. The method was validated and found to be precise, sensitive,specific, linear, accurate, and robust. The method validation study's findings demonstrated the method's suitability for routine use.The HPLC method was successfully applied to a marketed formulation containing rhizome powder from Curcuma angustifolia Roxb.as one of its constituents. This study investigates the antifungal activity of the methanolic extract in vitro using an agar well diffusionassay method. A minimum inhibitory concentration (MIC) was established, and the antifungal activity was evaluated against Candidaalbicans and Candida glabrata with fluconazole as the standard reference. The development and validation of an HPLC method fortesting curcuminoids in Curcuma angustifolia Roxb. rhizome and the evaluation of rhizome extract antifungal activity are excellentexamples of herbal medicine quality control in its entirety. The in vitro antifungal activity results reaffirm the usage of Curcumaangustifolia Roxb. as a source of antifungal agents. They can lead to the developing of new herbal medicines in the coming days.
{"title":"Method Development and Validation of Curcuminoids in Curcuma Angustifolia Roxb. By RP-HPLC and Its Antifungal Activity","authors":"Pravith P Warrier, Madhavi R Badole","doi":"10.22376/ijlpr.2023.13.6.l57-l71","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l57-l71","url":null,"abstract":"Curcuma angustifolia Roxb., a rhizomatous herb, belongs to the Zingiberaceae family of plants. The species is rich innutrients and is used mostly as a source of starch for Indian dishes and medicines. The published research articles for themeasurable estimation of components in Curcuma angustifolia Roxb. rhizomes are very scarce. The present study aimed to developa quantitative analysis method for estimating the constituents in the methanolic extract of Curcuma angustifolia Roxb. rhizome andto investigate its biological activity. Within the context of this challenge, the current work is a unique effort that recommends ahigh-performance liquid chromatography (HPLC) method for estimating curcuminoids, namely curcumin, demethoxycurcumin,and bis-demethoxycurcumin, present in the methanolic extract of Curcuma angustifolia Roxb. rhizome. A reverse-phase HPLCmethod was developed to estimate curcuminoids in the extract. The method was validated and found to be precise, sensitive,specific, linear, accurate, and robust. The method validation study's findings demonstrated the method's suitability for routine use.The HPLC method was successfully applied to a marketed formulation containing rhizome powder from Curcuma angustifolia Roxb.as one of its constituents. This study investigates the antifungal activity of the methanolic extract in vitro using an agar well diffusionassay method. A minimum inhibitory concentration (MIC) was established, and the antifungal activity was evaluated against Candidaalbicans and Candida glabrata with fluconazole as the standard reference. The development and validation of an HPLC method fortesting curcuminoids in Curcuma angustifolia Roxb. rhizome and the evaluation of rhizome extract antifungal activity are excellentexamples of herbal medicine quality control in its entirety. The in vitro antifungal activity results reaffirm the usage of Curcumaangustifolia Roxb. as a source of antifungal agents. They can lead to the developing of new herbal medicines in the coming days.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"74 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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