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Accelerator based epithermal neutron source for clinical boron neutron capture therapy 基于加速器的超热中子源用于临床硼中子俘获治疗
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-12-08 DOI: 10.3233/jnr-220037
N. Hu, Hiroki Tanaka, K. Akita, R. Kakino, T. Aihara, K. Nihei, K. Ono
The world’s first accelerator based epithermal neutron source for clinical boron neutron capture therapy (BNCT) was designed, developed, and commissioned between 2008 and 2010 by Sumitomo Heavy Industries in collaboration with Kyoto University at the Kyoto University Institute for Integrated Radiation and Nuclear Science. The accelerator system is cyclotron-based and accelerates a proton up to an energy of approximately 30 MeV. The proton strikes a beryllium target, which produces fast neutrons that traverse a beam shaping assembly composed of a combination of lead, iron, aluminum, and calcium fluoride to reduce the neutron energy down to the epithermal range (∼10 keV) suitable for BNCT. The system is designed to produce an epithermal neutron flux of up to 1.4 × 10 9 n · cm − 2 · s − 1 (exiting from the moderator of a 12 cm diameter collimator) with a proton current of 1 mA. In 2017, the same type of accelerator was installed at the Kansai BNCT Medical Center and in March 2020 the system received medical device approval in Japan (Sumitomo Heavy Industries, NeuCure® BNCT system). Soon after, BNCT for unresectable, locally advanced, and recurrent carcinoma of the head and neck region was approved by the Japanese government for reimbursement covered by the national health insurance system.
世界上第一个基于加速器的超热中子源,用于临床硼中子捕获治疗(BNCT),由住友重工与京都大学综合辐射与核科学研究所合作,于2008年至2010年设计、开发并投入使用。加速器系统以回旋加速器为基础,将质子加速到大约30兆电子伏的能量。质子撞击铍靶,产生快中子,这些快中子穿过由铅、铁、铝和氟化钙组成的束成形组件,将中子能量降低到适合BNCT的超热范围(~ 10 keV)。该系统设计产生的超热中子通量高达1.4 × 10 9 n·cm−2·s−1(从直径12 cm的准直器的慢化剂流出),质子电流为1 mA。2017年,关西BNCT医疗中心安装了相同类型的加速器,并于2020年3月获得了日本医疗器械批准(住友重工,neuure®BNCT系统)。不久之后,日本政府批准了针对头颈部不可切除、局部晚期和复发性癌的BNCT,并将其纳入国民健康保险体系。
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引用次数: 1
Decay heat in ISIS spallation target: simulations and measurements ISIS散裂靶的衰变热:模拟与测量
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-12-01 DOI: 10.3233/jnr-220030
L. Quintieri, S. Lilley, D. Wilcox, D. Findlay, D. Jenkins, S. Gallimore, D. Haynes
Spallation targets for neutron production with high energy protons are made of high density and high atomic number materials in order to maximise the yield of neutrons for all the instruments around. Operating a proton beam onto a spallation target produces residual radioactive nuclei either as direct product of the spallation process and as secondary low energy neutron absorption. A reliable estimation of the overall activation and decay heat, as a function of the cooling time and irradiation profile history, is fundamental for a valuable design of the radiation shielding and cooling system during the operation phase as well for envisaging the optimal storage solution at the end of life of the target. This work presents the comparison between the FLUKA predictions of the decay heat in the ISIS TS1 target operated between 2014 and 2019 and the decay heat estimations derived from the measurement of the temperature in each plate at different cooling times. The agreement between the FLUKA predictions and the experimentally assessed values shows and quantifies the goodness of the FLUKA model in predicting measurable physical quantities relevant for the engineering thermal design of the target/reflector and moderator (TRAM) assembly. In addition, it also provides an indirect evidence of the accuracy of the simulated spallation physics and neutron transport throughout the TRAM assembly. Finally this work attempts to highlight and propose a general empirical procedure that could be eventually applied and used to proficiently measure the decay heat at whatever cooling time in targets with similar ISIS design.
用高能质子产生中子的散裂靶是由高密度和高原子序数的材料制成的,以便使周围所有仪器的中子产量最大化。在散裂靶上操作质子束会产生残余的放射性核,这要么是散裂过程的直接产物,要么是次级低能中子吸收。作为冷却时间和辐照剖面历史的函数,对总体活化热和衰变热的可靠估计是运行阶段辐射屏蔽和冷却系统有价值设计的基础,也是在目标寿命结束时设想最佳存储解决方案的基础。本研究比较了2014年至2019年期间运行的ISIS TS1目标的FLUKA预测和不同冷却时间下每个板的温度测量得出的衰减热估计。FLUKA预测与实验评估值之间的一致性显示并量化了FLUKA模型在预测与目标/反射器和慢化剂(TRAM)组件的工程热设计相关的可测量物理量方面的优点。此外,它还间接证明了模拟散裂物理和中子输运在整个TRAM组件中的准确性。最后,本工作试图强调并提出一个一般的经验程序,该程序最终可以应用并用于熟练地测量具有类似ISIS设计的目标在任何冷却时间的衰变热。
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引用次数: 0
Very cold and ultra cold neutron sources for ESS 极冷和超冷中子源用于ESS
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-11-28 DOI: 10.3233/jnr-220040
L. Zanini, E. Dian, D. Dijulio, B. Folsom, E. Klinkby, Z. Kókai, J. I. Marquez Damian, B. Rataj, N. Rizzi, V. Santoro, M. Strothmann, A. Takibayev, R. Wagner, O. Zimmer
The goal of the “Workshop on Very Cold and Ultra Cold Neutron Sources for ESS” was to discuss scientific cases, ideas and possibilities for the implementation of sources of Very Cold and Ultra Cold neutrons at the European Spallation Source. The ESS facility, presently under construction, offers several possibilities for in-pile UCN or VCN sources, in primis thanks to the available space below the spallation target where additional neutron sources can be placed to complement those above the target. Neutron beams can be extracted over a wide angular range with a grid of forty-two beamports with 6° average angular separation, allowing future instruments to be installed which may view either the upper or lower moderator systems. Of greatest interest for fundamental physics is the so-called Large Beamport foreseen for the NNBAR experiment. This beamport is also particularly well suited to feed a UCN source, for which several ideas were presented that employ either superfluid helium or solid deuterium as established neutron converter materials. Concepts for VCN sources make use of novel materials for VCN production and/or advanced reflectors to increase yields in the coldest part of the neutron spectrum from a cryogenic neutron source. In this paper we discuss these ideas and the possible locations of UCN and VCN sources at ESS.
“用于ESS的极冷和超冷中子源研讨会”的目标是讨论在欧洲散裂源上实施极冷和超冷中子源的科学案例、想法和可能性。ESS设施目前正在建设中,提供了几种桩内UCN或VCN源的可能性,主要是由于散裂目标下方的可用空间,可以放置额外的中子源来补充目标上方的中子源。中子束可以在宽角度范围内提取,42个平均角间距为6°的光束,允许安装未来的仪器,可以观察上部或下部慢化系统。基础物理学最感兴趣的是NNBAR实验中预期的所谓的大光束港。这种光束端口也特别适合于供给UCN源,为此提出了几种使用超流氦或固体氘作为既定中子转换器材料的想法。VCN源的概念是利用VCN生产的新材料和/或先进的反射器来提高低温中子源中子谱中最冷部分的产量。在本文中,我们讨论了这些想法以及在ESS中UCN和VCN源的可能位置。
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引用次数: 2
Target cooling options for DARIA compact neutron source DARIA紧凑型中子源的目标冷却选择
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-11-25 DOI: 10.3233/jnr-220025
A. R. Moroz, N. Kovalenko, S. Grigoriev
The extensive heat release in the target is the primary limiting factor for a CANS neutron output. CANS DARIA has been chosen to operate using a 13 MeV proton beam providing up to 40 kW of power, which requires an effective target cooling solution. It was found that beryllium provides the best neutron yield while staying in solid state, which makes it the most effective option for the target material. With an optimal beryllium target thickness of 1.1 mm, the proton Bragg peak lies outside of the beryllium layer, but 9.21 MeV per incident proton are still dissipated inside the beryllium. Two cooling options are considered and analysed with PHITS calculations: multilayer targets and rotating targets. The use of proton beams with energies above 13 MeV on beryllium leads to tritium generation, which is not desirable. Any lower energy leads to a decreased neutron yield, but a simpler cooling solution. Therefore, an option to reduce the proton beam energy is also considered.
靶中的大量热释放是CANS中子输出的主要限制因素。CANS DARIA已被选择使用13MeV质子束运行,提供高达40kW的功率,这需要有效的目标冷却解决方案。研究发现,铍在保持固态的同时提供了最好的中子产率,这使其成为靶材料最有效的选择。在最佳铍靶厚度为1.1mm的情况下,质子布拉格峰位于铍层之外,但每个入射质子仍在铍内部耗散9.21MeV。通过PHITS计算,考虑并分析了两种冷却方案:多层靶和旋转靶。在铍上使用能量超过13MeV的质子束会产生氚,这是不可取的。任何较低的能量都会导致中子产率降低,但冷却解决方案更简单。因此,还考虑了降低质子束能量的选项。
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引用次数: 0
Sample-motion-synchronized neutron stroboscope at RANS RANS的样品运动同步中子频闪仪
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-26 DOI: 10.3233/jnr-220035
A. Taketani, Takaoki Takanashi, C. Iwamoto, Tomohiro Kobayashi, Masato Takamura
A sample-motion-synchronized neutron stroboscope is developed using the RIKEN accelerator-based compact neutron source (RANS). When a sample reaches a specified rotation phase, a phase timing signal is generated, triggering a proton pulse at the proton accelerator. A neutron pulse exposes the imaging detector through the sample. By controlling the delay time between the phase signal and the proton pulse timing, the neutron exposure timing is always synchronized with the specific sample rotation phase. A sample rotating at a speed of 1800 RPM is prepared, and clear still images of neutrons are taken.
利用基于RIKEN加速器的紧凑型中子源(RANS)开发了一种样品运动同步中子频闪仪。当样品达到指定的旋转相位时,产生相位计时信号,触发质子加速器处的质子脉冲。中子脉冲通过样品暴露成像探测器。通过控制相位信号和质子脉冲定时之间的延迟时间,中子暴露定时总是与特定的样品旋转相位同步。准备以1800RPM的速度旋转的样品,并拍摄中子的清晰静止图像。
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引用次数: 0
The ESS Monolith Vessel design and possibilities to introduce a UCN/VCN source ESS单片容器的设计和引入UCN/VCN源的可能性
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-21 DOI: 10.3233/jnr-220014
U. Odén
The ESS ERIC neutron source design includes a helium cooled tungsten spallation target and a liquid hydrogen moderator, enclosed in a vacuum vessel (the monolith vessel – spallation source vacuum chamber). The neutron source and moderator are shielded by stainless steel and casted iron to block neutron and gamma radiation emitted in directions outside of the neutron guide lines. After the ESS concept design was approved, discussions were raised if it was possible to introduce a UCN/VCN (Ultra Cold Neutron / Very Cold Neutron) source into the ESS design. Since the shielding concept of the monolith vessel is to 100% fill the monolith void, outside of the proton and neutron path, there are no cavities in the monolith vessel to easily introduce an UCN/VCN source. In addition, pipe routing supporting the UCN/VCN cooling media, will also challenge the possible UCN/VCN positions. However, some of the shielding blocks and monolith components are removable and could possibly be redesigned, enabling a UCN/VCN source feature. The article presents a feasibility study how to physically introduce a UCN/VCN source in the present ESS design, and focus on the geometrical possibilities. Four possible locations for the UCN/VCN source are identified and presented in the article. The locations are selected considered reasonable impact to the existing design. Pros and cons are discussed. All of the four presented locations are feasible but will, to some extent, require redesign of the monolith vessel shielding.
ESS ERIC中子源设计包括一个氦冷却的钨散裂靶和一个液氢慢化剂,封闭在一个真空容器中(单体容器-散裂源真空室)。中子源和慢化剂由不锈钢和铸铁屏蔽,以阻挡向中子导线以外方向发射的中子和伽马辐射。ESS概念设计获得批准后,讨论了是否有可能在ESS设计中引入UCN/VCN(超冷中子/极冷中子)源。由于整体容器的屏蔽概念是100%填充整体空隙,在质子和中子路径之外,整体容器中没有容易引入UCN/VCN源的空腔。此外,支持UCN/VCN冷却介质的管道路由也将挑战可能的UCN/VCN位置。然而,一些屏蔽块和整体组件是可拆卸的,可以重新设计,从而实现UCN/VCN源功能。本文对当前ESS设计中物理引入UCN/VCN源的可行性进行了研究,并重点讨论了几何上的可能性。本文确定并介绍了UCN/VCN源的四个可能位置。选址考虑了对现有设计的合理影响。讨论了利弊。所有提出的四个地点都是可行的,但在某种程度上,需要重新设计整体容器屏蔽。
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引用次数: 0
Development of UCN sources at PNPI PNPI的UCN源开发
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-19 DOI: 10.3233/jnr-220007
A. Serebrov, Vitaliy Lyamkin
This article reviews the development of various sources for ultracold neutrons (UCNs) at the Petersburg Nuclear Physics Institute (PNPI). For 45 years, PNPI has proposed and manufactured cryogenic devices for neutron conversion to low energies. Based on beryllium, hydrogen and deuterium, they can be operated in the intense radiation fields near the core of a nuclear reactor. A more recently launched UCN source development utilizes superfluid helium (He-II) as conversion medium. Initially proposed and designed for PNPI’s old WWR-M reactor, the project has been reshaped to equip the institute’s PIK reactor with a modern UCN source of this type. The projected UCN density in the closed source chamber is 2.2 × 103 cm−3, which, as calculations of neutron transport show, will provide 200 cm−3 in the chambers of a neutron EDM spectrometer connected to the source by a UCN guide. Experiments at PNPI with a full-scale UCN source model have demonstrated that a heat load of 60 W can be removed from the He-II in the converter at a temperature of 1.37 K. This fact confirms the practical possibility to implement low-temperature converters under “in-pile” conditions with large heat inflows. The review concludes with a presentation of various proposed options for a He-II based UCN source at the European Spallation Source.
本文综述了彼得堡核物理研究所(PNPI)超冷中子(UCN)各种来源的发展。45年来,PNPI提出并制造了用于中子转化为低能量的低温装置。基于铍、氢和氘,它们可以在核反应堆堆芯附近的强辐射场中运行。最近启动的UCN源开发利用超流氦(He II)作为转换介质。该项目最初是为PNPI的旧WWR-M反应堆提出和设计的,现在已经进行了改造,为该研究所的PIK反应堆配备了这种类型的现代UCN源。封闭源室内的预计UCN密度为2.2×103 cm−3,正如中子输运计算所示,这将在通过UCN导管连接到源的中子EDM光谱仪的室内提供200 cm−3。使用全尺寸UCN源模型在PNPI进行的实验表明,在1.37 K的温度下,可以从转换器中的He II中去除60 W的热负荷。这一事实证实了在具有大量热流入的“堆内”条件下实施低温转换器的实际可能性。审查结束时,在欧洲散裂震源介绍了基于He II的UCN震源的各种拟议方案。
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引用次数: 2
Simulation and design of an IPHI-based neutron source, first steps toward SONATE 基于IPHI的中子源的模拟和设计,迈向SONATE的第一步
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-18 DOI: 10.3233/jnr-220027
B. Mom, L. Thulliez, Eric Dumonteil, M. Binois, Y. Richet, J. Schwindling, A. Drouart
Facilities providing bright thermal neutron beams are of primary importance for various research topics. At CEA-Saclay, a compact accelerator driven neutron source, SONATE, is investigated in taking advantage of the IPHI accelerator able to deliver a 3 MeV proton beam with an intensity up to 100 mA. To optimize the performances of such a neutron source, it is necessary to maximize the thermal neutron flux while minimizing the contribution of other particles. In this work, optimization has been performed using the Monte Carlo code TOUCANS, a neutron transport code based on Geant4 developed at CEA-Saclay. This latter has been coupled to PROMETHEE, a software allowing multi-objective optimization for many simulation software. In this work the Kriging metamodel based approach is used to optimize a neutron beamdump. To take into account the various constraints, noise on the detection system and radiation protection issues, several beamdump configurations are evaluated. The variation of beamdump parameters makes it possible to identify the set of optimal solutions, the Pareto front. It allows to focus on the set of best choices and to choose wisely the best configurations. After describing the validation of TOUCANS on experimental tests performed from 2016 to 2022, the capability of such an approach will be presented.
提供明亮热中子束的设施对于各种研究主题具有首要重要性。在CEA Saclay,研究了一种紧凑型加速器驱动的中子源SONATE,它利用了IPHI加速器,能够输送强度高达100mA的3MeV质子束。为了优化这种中子源的性能,有必要最大化热中子通量,同时最小化其他粒子的贡献。在这项工作中,使用蒙特卡罗代码TOUCANS进行了优化,这是一种基于CEA Saclay开发的Geant4的中子输运代码。后者与PROMETHEE相耦合,PROMETHEE是一种允许对许多模拟软件进行多目标优化的软件。在这项工作中,基于克里格元模型的方法被用于优化中子束堆。为了考虑各种约束、检测系统上的噪声和辐射防护问题,对几种波束转储配置进行了评估。波束转储参数的变化使得识别最优解集Pareto前沿成为可能。它允许专注于一组最佳选择,并明智地选择最佳配置。在描述了TOUCANS在2016年至2022年进行的实验测试中的验证后,将介绍这种方法的能力。
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引用次数: 1
Experimental validation of cold neutron source performance with mesitylene moderator installed at RANS RANS安装均三甲苯慢化剂对冷中子源性能的实验验证
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-17 DOI: 10.3233/jnr-220034
Yujiro Ikeda, M. Teshigawara, M. Yan, C. Iwamoto, Kunihiro Fujita, Yutaka Abe, Y. Wakabayashi, A. Taketani, Takaoki Takanashi, M. Harada, T. Hashiguchi, Yutaka Yamagata, Yoshio Matsuzaki, B. Ma, M. Takamura, M. Mizuta, Makoto Goto, S. Ikeda, Tomohiro Kobayashi, Y. Otake
The RANS (RIKEN Accelerator driven Neutron Source), one of compact accelerator neutron sources (CANS), tries to expand its performance by installing a cold neutron which may provide new opportunities in many applications. RANS is a low power CANS with a proton beam of 7 MeV and 100 µA at maximum. A moderator system was constructed based on results of optimization design study with mesitylene. Recently, we have done performance tests aiming at showing characteristics as cold neutron source. Cryogenic mesitylene moderator was installed on a plug with a new target moderator reflector configuration of RANS. Experiment using a gas electron multiplier (GEM) detector was carried out to measure neutron spectra of the cold moderator. This paper describes performance of the cold moderator in terms of 1) Cold neutron gain of optimization design with respect to a polyethylene moderator, 2) Temperature dependency of cold neutron spectrum flux regarding scattering kernel (SK), and 3) comparison between experiment and calculation. A note is given for comparison between calculations with different SKs available. Also, two-dimensional imaging of cold and thermal neutron spectrum flux on the viewed surface is shown with a pinhole slit configuration.
RANS (RIKEN加速器驱动中子源)是紧凑型加速器中子源(can)的一种,它试图通过安装一个冷中子来扩展其性能,这可能为许多应用提供新的机会。RANS是一种低功率can,最大质子束为7 MeV和100 μ a。在优化设计研究结果的基础上,构建了以三聚甲苯为原料的减速剂系统。最近,我们针对冷中子源的特性进行了性能测试。低温三甲减速剂安装在一个插头与新的目标减速剂反射器配置的RANS。利用气电子倍增器(GEM)对冷慢化剂的中子能谱进行了测量。本文从冷中子增益对聚乙烯慢化剂的优化设计、冷中子能谱通量对散射核(SK)的温度依赖性、实验与计算的对比等方面介绍了冷慢化剂的性能。附注用于比较不同可用SKs的计算。此外,在观察表面上的冷中子和热中子能谱通量的二维成像显示为针孔狭缝结构。
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引用次数: 1
Long term operation of a 30 kW Beryllium target at IPHI IPHI 30kW铍靶的长期运行
IF 1.1 Q3 NUCLEAR SCIENCE & TECHNOLOGY Pub Date : 2022-10-07 DOI: 10.3233/jnr-220024
J. Schwindling, B. Annighöfer, N. Chauvin, J. Meuriot, B. Mom, Frédéric Ott, N. Sellami, L. Thulliez
Following tests of low power bulk Beryllium targets in 2016–2020, a high power target was designed, built and tested at the High Intensity Proton Injector (IPHI) at CEA Paris–Saclay. The design of the target and the results of the tests will be described.
在2016-2020年进行了低功率体铍靶的测试之后,在CEA Paris-Saclay的高强度质子注入器(IPHI)上设计、制造并测试了一个高功率靶。将描述靶的设计和试验结果。
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引用次数: 1
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Journal of Neutron Research
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