Journal of Neurorestoratology最新文献

英文中文

The effects of weight training and Aklil-ol-Malek on histopathology and C-reactive protein, nuclear factor erythroid-derived 2-like 2 beta-site Amyloid Precursor protein cleaving enzyme1 genes expression in Alzheimer's disease model rats 重量训练和Aklil-ol-Malek对阿尔茨海默病模型大鼠组织病理学及c反应蛋白、核因子红细胞源性2-样2 β -位点淀粉样前体蛋白切割酶1基因表达的影响

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-04-08 DOI: 10.1016/j.jnrt.2025.100206

Farah Nameni , Mohammad Reza Amir Khan Dehkordi

Background

Oxidative stress and neuroinflammation are key factors in the pathophysiology of Alzheimer's disease (AD). Exercise and Aklil-ol-Malek may reduce AD symptoms. Therefore, the current study investigated the effect of weight training and Aklil-ol-Malek consumption on histopathological and inflammatory changes in hippocampal tissue of male AD model rats.

Method

We prepared 55 8-week-old male Wistar rats and transferred them to an animal laboratory. The rats were randomly divided into five groups: healthy control group, Alzheimer's control group, Alzheimer's group + weight training, Alzheimer's group + Aklil-ol-Malek supplement, and Alzheimer's group + Aklil-ol-Malek supplement + weight training. AD was induced in the 4 groups. The weight training protocol and Aklil-ol-Malek supplementation were examined as an intervention. The designated groups were administered Aklil-ol-Malek supplements. The anesthetized rats' hippocampi were extracted for further analysis 72 hours after the last session of the protocol. After the induction of AD and supplementation, two-way analysis of variance was used to examine the differences between groups (p < 0.05).

Results

The results showed a decrease in the expression of CRP and NFE2L2 genes in rats in the Aklil-ol-Malek and weight training group compared with the findings in rats in the Alzheimer's group. Changes in the expression of BACE1 were not significant in rats in the weight training with Aklil-ol-Malek group.

Conclusion

An intervention receiving exercise and Aklil-ol-Malek extract positively improved health and reduced AD progression. These results were likely to have been caused by the physiological effects of exercise and the antioxidant properties of Aklil-ol-Malek.

背景氧化应激和神经炎症是阿尔茨海默病（AD）病理生理的关键因素。运动和Aklil-ol-Malek可以减轻AD症状。因此，本研究探讨了力量训练和aklli -ol- malek消耗对雄性AD模型大鼠海马组织病理和炎症变化的影响。方法制备55只8周龄雄性Wistar大鼠，转入动物实验室。将大鼠随机分为5组：健康对照组、阿尔茨海默病对照组、阿尔茨海默病组+重量训练、阿尔茨海默病组+ Aklil-ol-Malek补充剂、阿尔茨海默病组+ Aklil-ol-Malek补充剂+重量训练。4组均诱发AD。重量训练方案和Aklil-ol-Malek补充剂作为干预措施进行检查。指定的组服用Aklil-ol-Malek补充剂。在最后一次治疗72小时后，提取麻醉大鼠海马进行进一步分析。诱导AD和补充后，采用双向方差分析检验组间差异(p <；0.05)。结果与阿尔茨海默病组相比，aklli - l- malek组和重量训练组大鼠的CRP和NFE2L2基因表达降低。在aklli -ol- malek组大鼠中，BACE1的表达变化不显著。结论给予运动和阿克利尔-欧-马勒提取物的干预可以改善健康状况，减少AD的进展。这些结果可能是由运动的生理作用和Aklil-ol-Malek的抗氧化特性引起的。

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引用次数: 0

Application and progress of magnetic field therapy for spinal cord injury 磁场治疗脊髓损伤的应用与进展

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-28 DOI: 10.1016/j.jnrt.2025.100205

Zicai Liu , Zhanxiang Lin , Xuejin Liu , Xiuying Xie , Cheng Tan

Spinal cord injury (SCI), which results in severe neurological loss and multiple complications, remains a global health problem. Although SCI is a central nervous system injury, the field of related therapies has shown great promise, with breakthroughs regarding the theory of central nervous system irreparability. However, from the perspective of neuroprosthetics, the relevant basic theories are not always fully recognized or clearly understood, which poses a challenge to clinical practice guidance. Magnetic therapy technology has developed rapidly in recent years, and various magnetic therapy methods have emerged. Magnetic field therapy (MFT), with applications in SCI treatment, is considered a promising strategy for nerve repair and provides a theoretical foundation for subsequent research. MFT, including transcranial magnetic stimulation, static magnetic field, and pulsed electromagnetic field, has been used preclinically, and clinical studies have shown potential efficacy in SCI. Moreover, preclinical studies have revealed that MFT promotes nerve repair, reduces inflammatory responses, improves motor function, and enhances bladder control. They have also demonstrated that MFT is safe in human SCI patients and may improve motor function and pain control. However, its translation from preclinical studies to clinical application faces many challenges, including biological differences, determination of dose and treatment parameters, assessment of safety and side effects, and ethical and regulatory compliance. The present article aims to provide a comprehensive review of the applications and advances of MFT in SCI, to guide future research and provide a reference for clinical treatment. An in-depth discussion of MFT in the field of SCI may provide new ideas and directions for neural repair in SCI.

脊髓损伤（SCI）是一个全球性的健康问题，可导致严重的神经功能丧失和多种并发症。虽然脊髓损伤是一种中枢神经系统损伤，但随着中枢神经系统不可修复理论的突破，相关治疗领域显示出巨大的前景。然而，从神经修复学的角度来看，相关的基础理论并没有得到充分的认识和清晰的理解，这给临床实践指导带来了挑战。磁疗技术近年来发展迅速，各种磁疗方法层出不穷。磁场治疗（MFT）在脊髓损伤治疗中的应用，被认为是一种有前景的神经修复策略，为后续研究提供了理论基础。MFT包括经颅磁刺激、静态磁场和脉冲电磁场，已在临床前应用，临床研究显示出对脊髓损伤的潜在疗效。此外，临床前研究表明MFT促进神经修复，减少炎症反应，改善运动功能，增强膀胱控制。他们还证明MFT对人类脊髓损伤患者是安全的，并可能改善运动功能和疼痛控制。然而，从临床前研究到临床应用面临诸多挑战，包括生物学差异、剂量和治疗参数的确定、安全性和副作用的评估、伦理和法规遵从性等。本文旨在对MFT在SCI中的应用及进展进行综述，以指导今后的研究，并为临床治疗提供参考。深入探讨MFT在脊髓损伤领域的应用，可能为脊髓损伤的神经修复提供新的思路和方向。

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引用次数: 0

Advances in clinical neurorestorative treatments of Parkinson's disease 帕金森病神经修复治疗的临床进展

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-26 DOI: 10.1016/j.jnrt.2025.100204

Yixuan Yin , Dongning Su , Joyce S.T. Lam , Tao Feng

Increasing dopamine levels using oral levodopa administration has been the gold standard for treating Parkinson's disease (PD), but motor complications that occur with the progression of PD seriously affect patient quality of life. Neurorestorative treatments have provided new possibilities for PD therapies. This review summarizes the recent clinical progress in several aspects of neurorestorative strategies: cell therapy, bioengineering and tissue engineering therapy, pharmacological therapy, neurostimulation/neuromodulation, and brain–computer interfaces. However, progress has mainly been related to exploratory experimental results, and more evidence is needed to further verify the safety and efficacy of these neurorestorative treatments in PD.

口服左旋多巴增加多巴胺水平一直是治疗帕金森病（PD）的金标准，但随着PD进展而发生的运动并发症严重影响患者的生活质量。神经修复治疗为帕金森病的治疗提供了新的可能性。本文综述了近年来神经修复策略在细胞治疗、生物工程和组织工程治疗、药物治疗、神经刺激/神经调节和脑机接口等方面的临床进展。然而，进展主要与探索性实验结果有关，需要更多的证据来进一步验证这些神经恢复性治疗在PD中的安全性和有效性。

引用次数: 0

Relationship between major depression and cervical spondylosis: A two-sample bidirectional mendelian randomization study 重度抑郁症与颈椎病的关系：一项双样本双向孟德尔随机化研究

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-22 DOI: 10.1016/j.jnrt.2025.100203

Dingyu Du , Guipeng Zhao , Yukai Huang , Longyi Chen, Jinping Liu

Background

This study aimed to explore the causal link between cervical spondylosis (CS) and major depression (MD) using a bidirectional Mendelian randomization (MR) analysis.

Methods

Bidirectional MR was employed to validate the bidirectional causal relationship between CS and MD using pooled data obtained from the Integrated Epidemiology Unit Open Genome Wide Association Study (GWAS) database. MR Egger, weighted median, inverse-variance weighted (IVW), and simple mode methods were used, with priority given to IVW results. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were performed to confirm the stability of the MR results.

Results

In a forward MR analysis, a causal effect was found between MD and CS (IVW: OR > 1, p < 0.05). However, a reverse MR analysis indicated no causal relationship between CS and MD (p > 0.05). Sensitivity analyses revealed no sample heterogeneity, no horizontal pleiotropy effect, and no significant bias, thus supporting the reliability of the MR analysis results.

Conclusion

This study provides evidence demonstrating that MD is causally associated with CS, whereas CS is not causally linked to MD. These findings offer novel insights into the pathogenesis of these two prevalent diseases.

本研究旨在通过双向孟德尔随机化（MR）分析探讨颈椎病（CS）与重度抑郁症（MD）之间的因果关系。方法利用综合流行病学单位开放全基因组关联研究（GWAS）数据库的汇总数据，采用双向磁共振验证CS与MD之间的双向因果关系。采用MR Egger、加权中位数、逆方差加权（IVW）和简单模式方法，IVW结果优先考虑。进行敏感性分析，包括异质性试验、水平多效性试验和留一法，以确认MR结果的稳定性。结果在正向磁共振分析中，MD与CS之间存在因果关系(IVW: OR >；1、p <；0.05)。然而，反向MR分析显示CS和MD之间没有因果关系(p >；0.05)。敏感性分析未发现样本异质性，无水平多效效应，无显著偏倚，支持MR分析结果的可靠性。结论本研究提供的证据表明MD与CS有因果关系，而CS与MD没有因果关系。这些发现为这两种流行疾病的发病机制提供了新的见解。

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引用次数: 0

The efficacy of transcutaneous auricular vagus nerve stimulation for patients with mild cognitive impairment and depressive symptoms: A case report and fMRI study 经皮耳迷走神经刺激对轻度认知障碍伴抑郁症状患者的疗效：1例报告及fMRI研究

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-20 DOI: 10.1016/j.jnrt.2025.100202

Chunlei Guo , Jifei Sun , Yue Ma , Shanshan Gao , Tianjiao Xu , Qingyan Chen , Lei Zhang , Jiudong Cao , Guolei Zhang , Yang Hong , Hua Yan , Ge Yang , Jiliang Fang

This case report details a patient diagnosed with mild cognitive impairment concurrently exhibiting depressive symptoms and undergoing 24 weeks of transcutaneous vagus nerve stimulation therapy. After the 24-week treatment, the patient demonstrated notable improvement in both cognitive function and mood. Simultaneously, significant alterations were observed in the patient's temporal pole and medial orbitofrontal gyrus, regions associated with cognition and emotion. Furthermore, the patient continued to maintain a favorable status throughout the follow-up period. Therefore, transcutaneous vagus nerve stimulation may be a potential treatment for patients with mild cognitive impairment and depressive symptoms.

本病例报告详细介绍了一位诊断为轻度认知障碍的患者，同时表现出抑郁症状，并接受了24周的经皮迷走神经刺激治疗。经过24周的治疗，患者的认知功能和情绪均有显著改善。同时，在患者的颞极和内侧眶额回（与认知和情绪相关的区域）观察到显著的改变。此外，患者在整个随访期间继续保持良好状态。因此，经皮迷走神经刺激可能是一种治疗轻度认知障碍和抑郁症状的潜在方法。

引用次数: 0

Neuroinflammation and neurorestoration following stroke: Molecular mechanisms and therapeutic approaches 脑卒中后的神经炎症和神经恢复：分子机制和治疗方法

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-17 DOI: 10.1016/j.jnrt.2025.100201

Liang Cao , Yi Zhang , Wenjun Pi , Voon Wee Yong , Mengzhou Xue

引用次数: 0

Corrigendum to “Primed low frequency repetitive Transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial” [J Neurorestoratol 13 (2025) 100169] “启动低频重复经颅磁刺激重新平衡大脑皮层兴奋抑制回路和改善婴儿脑瘫患者的功能预后：一项随机对照试验”[J]中华神经医学杂志13(2025):1009。

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-14 DOI: 10.1016/j.jnrt.2025.100192

Aliya Mufti , Suman Jain , Kanwal Preet Kochhar , Sheffali Gulati , Sanjay Wadhwa , Kapil Sikka , Rohit Saxena , Md Iqbal Alam

引用次数: 0

Neuronal intranuclear inclusion disease with sudden visual impairment 突发性视力损害的神经元核内包涵病

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-03-01 DOI: 10.1016/j.jnrt.2025.100193

Lili Liu , Juanjuan Chen , Zhijian Lin, Jun Hu, Yunong Li, Fenli Zhou

Here we report a case of a 67-year-old female patient who presented with headache, limb tremors, and acute complete vision loss. Physical examination revealed bilateral miosis, and diffusion-weighted imaging sequences showed mild diffusion restriction in the subcortical regions of both occipital lobes. Genetic results revealed 85 GGC repeats in the 5′-untranslated region of the NOTCH2NLC gene. The therapeutic effect of dexamethasone and acyclovir was minimal. NIID must be considered in patients with acute onset and various clinical manifestations and imaging findings similar to encephalitis. We hope that our case presentation will enhance clinicians’ awareness of NIID.

我们在此报告一位67岁的女性病患，表现为头痛、肢体震颤及急性完全视力丧失。体格检查显示双侧瞳孔缩小，弥散加权成像序列显示双侧枕叶皮质下区域轻度弥散受限。遗传结果显示，NOTCH2NLC基因的5 ' -非翻译区有85个GGC重复序列。地塞米松联合阿昔洛韦治疗效果不明显。急性发作且临床表现和影像学表现与脑炎相似的患者必须考虑NIID。我们希望我们的病例报告能提高临床医生对NIID的认识。

引用次数: 0

Advances in clinical neurorestorative treatments in brain trauma 脑外伤神经修复治疗的临床进展

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-02-14 DOI: 10.1016/j.jnrt.2025.100191

Qian Zhou , Wei Shen , Liang Wen

Traumatic brain injury (TBI) is a significant cause of mortality and disability globally, imposing a considerable burden on society and individuals. In recent years, neurorestorative therapies for TBI have attracted widespread attention. Despite the rapid progress in clinical neurorestorative treatments for TBI, few relevant reviews have been published. This review addresses advances in these strategies for patients with TBI, covering cellular therapies, neurostimulation therapies, brain-computer interfaces, pharmacologic therapies, and multidisciplinary therapies. This review aims to serve as a reference for clinical professionals treating patients with TBI, improving neurologic rehabilitation and outcomes for patients with TBI.

创伤性脑损伤（TBI）是导致全球死亡和残疾的一个重要原因，给社会和个人造成了相当大的负担。近年来，针对创伤性脑损伤的神经恢复疗法引起了广泛关注。尽管针对创伤性脑损伤的临床神经恢复疗法进展迅速，但相关综述却寥寥无几。本综述探讨了针对创伤性脑损伤患者的这些策略的进展，涵盖细胞疗法、神经刺激疗法、脑机接口、药物疗法和多学科疗法。本综述旨在为治疗创伤性脑损伤患者的临床专业人员提供参考，改善创伤性脑损伤患者的神经康复和治疗效果。

引用次数: 0

HIF1α/SLC7A11 signaling attenuates 6-hydroxydopamine-induced ferroptosis in animal and cell models of Parkinson’s disease HIF1α/SLC7A11信号通路在帕金森病动物和细胞模型中减弱6-羟多巴胺诱导的铁下垂

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-02-01 DOI: 10.1016/j.jnrt.2024.100171

Xuejia Liu , Zhisheng Han , Yuming Huang , Mingzhi Li , Jialu Tian , Shan Zhao , Yonghai Li , Juntang Lin , Han Li

Background

The pathogenesis of Parkinson’s disease (PD) is associated with ferroptosis. The role of HIF1α is involved in several diseases, but its specific function in PD remains uncertain.

Methods

In this study, we generated animal and cellular models of PD using the neurotoxin 6-OHDA. The occurrence of ferroptosis was determined by measuring levels of ferroptosis-related proteins, Fe²⁺ amount and transmission electron microscopy analysis in the PD models, and was further confirmed by using a ferroptosis inhibitor. HIF1α overexpressing and HIF1α knockdown SH-SY5Y cells were constructed by lentivirus transfection. Then, the levels of lipid peroxide, ROS, SLC7A11, and GPX4 were detected to elucidate the relationship between HIF1α and ferroptosis. Luciferase assay was used to analyze the regulation between HIF1α and SLC7A11.

Results

We observed a significant downregulation of HIF1α in both animal and cellular PD models. Overexpression of HIF1α mitigated 6-OHDA-induced ferroptosis in SH-SY5Y cells, while, conversely, downregulation of HIF1α promoted ferroptosis in SH-SY5Y cells. BioEdit Sequence Alignment Editor software identified a hypoxia response element (HRE) within the promoter sequence of SLC7A11. The dual-luciferase reporter assays demonstrated that the co-expression of HIF1α and the SLC7A11 promoter significantly augmented reporter activity in SH-SY5Y cells. Moreover, introduction of a mutation into the HRE of the SLC7A11 promoter abolished the induction of SLC7A11 by HIF1α overexpression, resulted in a reduction in promoter activity compared with wild-type cells.

Conclusions

The collective findings of this study indicate that HIF1α can inhibit ferroptosis by positively regulating SLC7A11. This investigation has shed light on the crucial involvement of the HIF1α/SLC7A11 signaling axis in ferroptosis in PD models, thereby presenting patients with PD a promising therapeutic target.

背景帕金森病（PD）的发病机制与铁下垂有关。HIF1α参与多种疾病，但其在PD中的具体功能尚不清楚。方法本研究采用神经毒素6-OHDA制备PD动物模型和细胞模型。通过测定PD模型中铁下垂相关蛋白水平、Fe2+量和透射电镜分析来确定铁下垂的发生，并使用铁下垂抑制剂进一步证实。慢病毒转染SH-SY5Y细胞构建HIF1α过表达和HIF1α低表达细胞。然后，检测脂质过氧化、ROS、SLC7A11和GPX4的水平，以阐明HIF1α与铁下垂的关系。荧光素酶法分析HIF1α与SLC7A11之间的调控作用。结果我们在动物和细胞PD模型中观察到HIF1α的显著下调。HIF1α的过表达减轻了6- ohda诱导的SH-SY5Y细胞铁下垂，而相反，HIF1α的下调促进了SH-SY5Y细胞铁下垂。BioEdit序列比对编辑器软件在SLC7A11的启动子序列中发现了一个缺氧反应元件（HRE）。双荧光素酶报告子实验表明，HIF1α和SLC7A11启动子的共表达显著增强了SH-SY5Y细胞中的报告子活性。此外，在SLC7A11启动子的HRE中引入突变消除了HIF1α过表达对SLC7A11的诱导，导致启动子活性与野生型细胞相比降低。结论HIF1α可通过正调控SLC7A11抑制铁下垂。这项研究揭示了HIF1α/SLC7A11信号轴在PD模型中铁下垂的关键作用，从而为PD患者提供了一个有希望的治疗靶点。

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