Pub Date : 2025-03-01DOI: 10.1016/j.jnrt.2025.100193
Lili Liu , Juanjuan Chen , Zhijian Lin, Jun Hu, Yunong Li, Fenli Zhou
Here we report a case of a 67-year-old female patient who presented with headache, limb tremors, and acute complete vision loss. Physical examination revealed bilateral miosis, and diffusion-weighted imaging sequences showed mild diffusion restriction in the subcortical regions of both occipital lobes. Genetic results revealed 85 GGC repeats in the 5′-untranslated region of the NOTCH2NLC gene. The therapeutic effect of dexamethasone and acyclovir was minimal. NIID must be considered in patients with acute onset and various clinical manifestations and imaging findings similar to encephalitis. We hope that our case presentation will enhance clinicians’ awareness of NIID.
{"title":"Neuronal intranuclear inclusion disease with sudden visual impairment","authors":"Lili Liu , Juanjuan Chen , Zhijian Lin, Jun Hu, Yunong Li, Fenli Zhou","doi":"10.1016/j.jnrt.2025.100193","DOIUrl":"10.1016/j.jnrt.2025.100193","url":null,"abstract":"<div><div>Here we report a case of a 67-year-old female patient who presented with headache, limb tremors, and acute complete vision loss. Physical examination revealed bilateral miosis, and diffusion-weighted imaging sequences showed mild diffusion restriction in the subcortical regions of both occipital lobes. Genetic results revealed 85 GGC repeats in the 5′-untranslated region of the <em>NOTCH2NLC</em> gene. The therapeutic effect of dexamethasone and acyclovir was minimal. NIID must be considered in patients with acute onset and various clinical manifestations and imaging findings similar to encephalitis. We hope that our case presentation will enhance clinicians’ awareness of NIID.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100193"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-14DOI: 10.1016/j.jnrt.2025.100191
Qian Zhou , Wei Shen , Liang Wen
Traumatic brain injury (TBI) is a significant cause of mortality and disability globally, imposing a considerable burden on society and individuals. In recent years, neurorestorative therapies for TBI have attracted widespread attention. Despite the rapid progress in clinical neurorestorative treatments for TBI, few relevant reviews have been published. This review addresses advances in these strategies for patients with TBI, covering cellular therapies, neurostimulation therapies, brain-computer interfaces, pharmacologic therapies, and multidisciplinary therapies. This review aims to serve as a reference for clinical professionals treating patients with TBI, improving neurologic rehabilitation and outcomes for patients with TBI.
{"title":"Advances in clinical neurorestorative treatments in brain trauma","authors":"Qian Zhou , Wei Shen , Liang Wen","doi":"10.1016/j.jnrt.2025.100191","DOIUrl":"10.1016/j.jnrt.2025.100191","url":null,"abstract":"<div><div>Traumatic brain injury (TBI) is a significant cause of mortality and disability globally, imposing a considerable burden on society and individuals. In recent years, neurorestorative therapies for TBI have attracted widespread attention. Despite the rapid progress in clinical neurorestorative treatments for TBI, few relevant reviews have been published. This review addresses advances in these strategies for patients with TBI, covering cellular therapies, neurostimulation therapies, brain-computer interfaces, pharmacologic therapies, and multidisciplinary therapies. This review aims to serve as a reference for clinical professionals treating patients with TBI, improving neurologic rehabilitation and outcomes for patients with TBI.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100191"},"PeriodicalIF":3.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jnrt.2024.100171
Xuejia Liu , Zhisheng Han , Yuming Huang , Mingzhi Li , Jialu Tian , Shan Zhao , Yonghai Li , Juntang Lin , Han Li
Background
The pathogenesis of Parkinson’s disease (PD) is associated with ferroptosis. The role of HIF1α is involved in several diseases, but its specific function in PD remains uncertain.
Methods
In this study, we generated animal and cellular models of PD using the neurotoxin 6-OHDA. The occurrence of ferroptosis was determined by measuring levels of ferroptosis-related proteins, Fe2+ amount and transmission electron microscopy analysis in the PD models, and was further confirmed by using a ferroptosis inhibitor. HIF1α overexpressing and HIF1α knockdown SH-SY5Y cells were constructed by lentivirus transfection. Then, the levels of lipid peroxide, ROS, SLC7A11, and GPX4 were detected to elucidate the relationship between HIF1α and ferroptosis. Luciferase assay was used to analyze the regulation between HIF1α and SLC7A11.
Results
We observed a significant downregulation of HIF1α in both animal and cellular PD models. Overexpression of HIF1α mitigated 6-OHDA-induced ferroptosis in SH-SY5Y cells, while, conversely, downregulation of HIF1α promoted ferroptosis in SH-SY5Y cells. BioEdit Sequence Alignment Editor software identified a hypoxia response element (HRE) within the promoter sequence of SLC7A11. The dual-luciferase reporter assays demonstrated that the co-expression of HIF1α and the SLC7A11 promoter significantly augmented reporter activity in SH-SY5Y cells. Moreover, introduction of a mutation into the HRE of the SLC7A11 promoter abolished the induction of SLC7A11 by HIF1α overexpression, resulted in a reduction in promoter activity compared with wild-type cells.
Conclusions
The collective findings of this study indicate that HIF1α can inhibit ferroptosis by positively regulating SLC7A11. This investigation has shed light on the crucial involvement of the HIF1α/SLC7A11 signaling axis in ferroptosis in PD models, thereby presenting patients with PD a promising therapeutic target.
{"title":"HIF1α/SLC7A11 signaling attenuates 6-hydroxydopamine-induced ferroptosis in animal and cell models of Parkinson’s disease","authors":"Xuejia Liu , Zhisheng Han , Yuming Huang , Mingzhi Li , Jialu Tian , Shan Zhao , Yonghai Li , Juntang Lin , Han Li","doi":"10.1016/j.jnrt.2024.100171","DOIUrl":"10.1016/j.jnrt.2024.100171","url":null,"abstract":"<div><h3>Background</h3><div>The pathogenesis of Parkinson’s disease (PD) is associated with ferroptosis. The role of HIF1α is involved in several diseases, but its specific function in PD remains uncertain.</div></div><div><h3>Methods</h3><div>In this study, we generated animal and cellular models of PD using the neurotoxin 6-OHDA. The occurrence of ferroptosis was determined by measuring levels of ferroptosis-related proteins, Fe<sup>2+</sup> amount and transmission electron microscopy analysis in the PD models, and was further confirmed by using a ferroptosis inhibitor. HIF1α overexpressing and HIF1α knockdown SH-SY5Y cells were constructed by lentivirus transfection. Then, the levels of lipid peroxide, ROS, SLC7A11, and GPX4 were detected to elucidate the relationship between HIF1α and ferroptosis. Luciferase assay was used to analyze the regulation between HIF1α and SLC7A11.</div></div><div><h3>Results</h3><div>We observed a significant downregulation of HIF1α in both animal and cellular PD models. Overexpression of HIF1α mitigated 6-OHDA-induced ferroptosis in SH-SY5Y cells, while, conversely, downregulation of HIF1α promoted ferroptosis in SH-SY5Y cells. BioEdit Sequence Alignment Editor software identified a hypoxia response element (HRE) within the promoter sequence of <em>SLC7A11</em>. The dual-luciferase reporter assays demonstrated that the co-expression of HIF1α and the <em>SLC7A11</em> promoter significantly augmented reporter activity in SH-SY5Y cells. Moreover, introduction of a mutation into the HRE of the <em>SLC7A11</em> promoter abolished the induction of SLC7A11 by HIF1α overexpression, resulted in a reduction in promoter activity compared with wild-type cells.</div></div><div><h3>Conclusions</h3><div>The collective findings of this study indicate that HIF1α can inhibit ferroptosis by positively regulating <em>SLC7A11</em>. This investigation has shed light on the crucial involvement of the HIF1α/SLC7A11 signaling axis in ferroptosis in PD models, thereby presenting patients with PD a promising therapeutic target.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100171"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jnrt.2024.100174
Hongyun Huang, Paul R. Sanberg, Hari Shanker Sharma, Sang Ryong Jeon
{"title":"The responsibility and mission of Neurorestoratology‒New year’s greetings for 2025","authors":"Hongyun Huang, Paul R. Sanberg, Hari Shanker Sharma, Sang Ryong Jeon","doi":"10.1016/j.jnrt.2024.100174","DOIUrl":"10.1016/j.jnrt.2024.100174","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100174"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multiple prenatal and postnatal etiologies in cerebral palsy (CP) patients cause neural tissue damage and alterations in cortical neuronal activity and plasticity, leading to motor and cognitive deficits early in life. Repetitive transcranial magnetic stimulation (rTMS) to the lesioned or contralesional hemisphere has been shown to alleviate these functional deficits. However, the underlying mechanisms of the beneficial effects of rTMS via realigning intracortical and interhemispheric circuitry and excitability remain unclear. The present study explored the ability of primed low-frequency rTMS to modulate intracortical excitatory-inhibitory circuitry, interhemispheric and corticospinal integrity, and plasticity in infantile hemiplegic CP.
Methods
The current study was a randomized, placebo-controlled trial with infantile hemiplegic CP patients. The active group received 6 Hz primed low-frequency 1Hz rTMS delivered to the contralesional primary motor cortex for 4 weeks, in 10 sessions. The placebo group received sham stimulation. Both groups also underwent 10 sessions of modified-constraint induced movement therapy (mCIMT). Pre- and post-intervention assessments were conducted using the Quality of Upper Extremity Skills Test to evaluate sensory and motor function, and the Modified Ashworth Scale (MAS) to assess spasticity. Additionally, cortical excitability and plasticity were measured using single- and paired-pulse TMS.
Results
We found a significant increase in Quality of Upper Extremity Skills Test scores, CP Quality of Life Child (CP QOL-Child) scores, and grip strength, and a decrease in MAS scores in the active rTMS group compared with the sham group. Single- and paired-pulse paradigms revealed a significant decrease in resting and active motor threshold, a reduction in the cortical silent period, and short- and long-interval intracortical inhibition in the intervention group compared with the sham group.
Conclusion
Primed low-frequency rTMS in the contralesional hemisphere combined with mCIMT shows potential for modulating motor neuronal excitability, rebalancing intracortical excitatory-inhibitory circuitry, and enhancing functional outcomes in children with infantile hemiparetic CP.
{"title":"Primed low frequency repetitive transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial","authors":"Aliya Mufti , Suman Jain , Kanwal Preet Kochhar , Sheffali Gulati , Sanjay Wadhwa , Kapil Sikka , Rohit Saxena , Md Iqbal Alam","doi":"10.1016/j.jnrt.2024.100169","DOIUrl":"10.1016/j.jnrt.2024.100169","url":null,"abstract":"<div><h3>Background</h3><div>Multiple prenatal and postnatal etiologies in cerebral palsy (CP) patients cause neural tissue damage and alterations in cortical neuronal activity and plasticity, leading to motor and cognitive deficits early in life. Repetitive transcranial magnetic stimulation (rTMS) to the lesioned or contralesional hemisphere has been shown to alleviate these functional deficits. However, the underlying mechanisms of the beneficial effects of rTMS via realigning intracortical and interhemispheric circuitry and excitability remain unclear. The present study explored the ability of primed low-frequency rTMS to modulate intracortical excitatory-inhibitory circuitry, interhemispheric and corticospinal integrity, and plasticity in infantile hemiplegic CP.</div></div><div><h3>Methods</h3><div>The current study was a randomized, placebo-controlled trial with infantile hemiplegic CP patients. The active group received 6 Hz primed low-frequency 1Hz rTMS delivered to the contralesional primary motor cortex for 4 weeks, in 10 sessions. The placebo group received sham stimulation. Both groups also underwent 10 sessions of modified-constraint induced movement therapy (mCIMT). Pre- and post-intervention assessments were conducted using the Quality of Upper Extremity Skills Test to evaluate sensory and motor function, and the Modified Ashworth Scale (MAS) to assess spasticity. Additionally, cortical excitability and plasticity were measured using single- and paired-pulse TMS.</div></div><div><h3>Results</h3><div>We found a significant increase in Quality of Upper Extremity Skills Test scores, CP Quality of Life Child (CP QOL-Child) scores, and grip strength, and a decrease in MAS scores in the active rTMS group compared with the sham group. Single- and paired-pulse paradigms revealed a significant decrease in resting and active motor threshold, a reduction in the cortical silent period, and short- and long-interval intracortical inhibition in the intervention group compared with the sham group.</div></div><div><h3>Conclusion</h3><div>Primed low-frequency rTMS in the contralesional hemisphere combined with mCIMT shows potential for modulating motor neuronal excitability, rebalancing intracortical excitatory-inhibitory circuitry, and enhancing functional outcomes in children with infantile hemiparetic CP.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100169"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jnrt.2024.100172
Yong Hu
{"title":"Top cited articles of 2023 in Journal of Neurorestoratology","authors":"Yong Hu","doi":"10.1016/j.jnrt.2024.100172","DOIUrl":"10.1016/j.jnrt.2024.100172","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100172"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jnrt.2024.100170
Weihong Wang , Qiang Tang , Hua Liu , Rong Xu , Lijun Zhang
Background
The aim of this meta-analysis was to evaluate the impact of the timing of single-event multilevel surgery (SEMLS) on long-term motor outcomes in children and adolescents with cerebral palsy (CP).
Methods
A systematic review and meta-analysis were conducted by searching PubMed, Cochrane Library, Embase, and Web of Science databases for studies up to April 2024. Twelve eligible studies were included, from which we examined patients’ gait, stride length, walking speed, and the gross motor function measure (GMFM66).
Results
Gait analysis showed significant improvements in CP patients after SEMLS, which included an increased gait deviation index (p < 0.001), reduced Gillette gait index (p < 0.001), and reduced gait profile score (p < 0.001). Subgroup analysis showed that age at surgery (<12 years old vs. 12−18 years old) was not a factor affecting patients’ gait. Spatial and temporal parameters such as stride length (p < 0.001) and walking velocity (p = 0.02) also improved significantly after surgery. However, there were only trends towards broader motor function gains measured by the GMFM66 (p = 0.39).
Conclusions
SEMLS effectively improved key gait and mobility parameters in children and adolescents with CP, and was not affected by younger or older surgical ages (<12 years old or 12−18 years old). However, these gait improvements do not uniformly translate into broader motor function gains.
{"title":"Timing of single-event multilevel surgical interventions on long-term motor outcomes in children and adolescents with cerebral palsy: A systematic review and meta-analysis","authors":"Weihong Wang , Qiang Tang , Hua Liu , Rong Xu , Lijun Zhang","doi":"10.1016/j.jnrt.2024.100170","DOIUrl":"10.1016/j.jnrt.2024.100170","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this meta-analysis was to evaluate the impact of the timing of single-event multilevel surgery (SEMLS) on long-term motor outcomes in children and adolescents with cerebral palsy (CP).</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted by searching PubMed, Cochrane Library, Embase, and Web of Science databases for studies up to April 2024. Twelve eligible studies were included, from which we examined patients’ gait, stride length, walking speed, and the gross motor function measure (GMFM66).</div></div><div><h3>Results</h3><div>Gait analysis showed significant improvements in CP patients after SEMLS, which included an increased gait deviation index (<em>p</em> < 0.001), reduced Gillette gait index (<em>p</em> < 0.001), and reduced gait profile score (<em>p</em> < 0.001). Subgroup analysis showed that age at surgery (<12 years old vs. 12−18 years old) was not a factor affecting patients’ gait. Spatial and temporal parameters such as stride length (<em>p</em> < 0.001) and walking velocity (<em>p</em> = 0.02) also improved significantly after surgery. However, there were only trends towards broader motor function gains measured by the GMFM66 (<em>p</em> = 0.39).</div></div><div><h3>Conclusions</h3><div>SEMLS effectively improved key gait and mobility parameters in children and adolescents with CP, and was not affected by younger or older surgical ages (<12 years old or 12−18 years old). However, these gait improvements do not uniformly translate into broader motor function gains.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 1","pages":"Article 100170"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-25DOI: 10.1016/j.jnrt.2025.100190
Qi Lu , Juan Hui , Haiyue Dai , Ran Hao , Yuesen Hou , Di Wang , Yongfeng Yang , Juan Li , Jinggui Song , Zhaohui Zhang
Background
High-definition transcranial direct current stimulation (HD-tDCS) and repetitive transcranial magnetic stimulation (rTMS) demonstrate significant potential for improving depressive symptoms and cognitive function; however, their effectiveness varies greatly among individuals. Functional near-infrared spectroscopy enables real-time monitoring of brain function during cognitive tasks in patients with psychiatric disorders.
Methods
A 4-week longitudinal study was conducted involving 61 patients with depression and 26 healthy controls. Patients were randomly assigned to HD-tDCS, rTMS, and antidepressant (AD) groups. Changes in depressive symptoms, adverse event rates, and prefrontal cortical oxyhemoglobin concentrations were assessed.
Result
At week 4, remission rates were 62.5% (15), 61.9% (13), and 62.5% (10) in the HD-tDCS, rTMS, and AD groups, respectively (x2 = 0.002, p = 1.000). Response rates were 66.7% (16), 71.4% (15), and 68.8% (11), respectively, with no significant difference between groups (x2 = 0.12, p = 0.941). All groups demonstrated significant improvement in depressive symptoms and cognitive function. The rTMS group exhibited a significantly greater decrease in Hamilton Depression Scale score compared with the HD-tDCS and AD groups. After 2 weeks of treatment, patients exhibited improved depressive symptoms and reduced activation during the verbal fluency task. However, these changes were not significantly correlated (r = −0.159 to 0.240, p = 0.121–0.988).
Limitations
All patients had concomitant use of ADs, which may impact near-infrared spectroscopy signaling and have an indeterminate effect on cognition.
Conclusion
HD-tDCS, rTMS, and ADs were equally effective, safe, and well-tolerated. HD-tDCS and rTMS were more effective for working memory, attention, executive functioning, and mood regulation.
高清晰度经颅直流电刺激（HD-tDCS）和重复性经颅磁刺激（rTMS）显示出改善抑郁症状和认知功能的显著潜力；然而，它们的效果因人而异。功能性近红外光谱能够实时监测精神疾病患者在认知任务期间的大脑功能。方法对61例抑郁症患者和26例健康对照者进行为期4周的纵向研究。患者被随机分配到HD-tDCS、rTMS和抗抑郁药（AD）组。评估抑郁症状、不良事件发生率和前额皮质氧合血红蛋白浓度的变化。结果第4周，HD-tDCS组、rTMS组和AD组的缓解率分别为62.5%（15例）、61.9%（13例）和62.5%（10例）（x2 = 0.002, p = 1.000）。有效率分别为66.7%（16例）、71.4%（15例）、68.8%（11例），组间差异无统计学意义（x2 = 0.12, p = 0.941）。所有组均表现出抑郁症状和认知功能的显著改善。与HD-tDCS和AD组相比，rTMS组汉密尔顿抑郁量表得分明显下降。治疗2周后，患者表现出抑郁症状的改善，在言语流畅性任务中的激活程度降低。然而，这些变化没有显著相关（r = - 0.159 ~ 0.240, p = 0.121 ~ 0.988）。局限性所有患者同时使用ADs，这可能影响近红外光谱信号，对认知有不确定的影响。结论hd - tdcs、rTMS和ADs的疗效、安全性和耐受性相同。HD-tDCS和rTMS在工作记忆、注意力、执行功能和情绪调节方面更有效。
{"title":"Comparison of the efficacy of high-definition transcranial direct current stimulation and transcranial magnetic stimulation in the treatment of depression","authors":"Qi Lu , Juan Hui , Haiyue Dai , Ran Hao , Yuesen Hou , Di Wang , Yongfeng Yang , Juan Li , Jinggui Song , Zhaohui Zhang","doi":"10.1016/j.jnrt.2025.100190","DOIUrl":"10.1016/j.jnrt.2025.100190","url":null,"abstract":"<div><h3>Background</h3><div>High-definition transcranial direct current stimulation (HD-tDCS) and repetitive transcranial magnetic stimulation (rTMS) demonstrate significant potential for improving depressive symptoms and cognitive function; however, their effectiveness varies greatly among individuals. Functional near-infrared spectroscopy enables real-time monitoring of brain function during cognitive tasks in patients with psychiatric disorders.</div></div><div><h3>Methods</h3><div>A 4-week longitudinal study was conducted involving 61 patients with depression and 26 healthy controls. Patients were randomly assigned to HD-tDCS, rTMS, and antidepressant (AD) groups. Changes in depressive symptoms, adverse event rates, and prefrontal cortical oxyhemoglobin concentrations were assessed.</div></div><div><h3>Result</h3><div>At week 4, remission rates were 62.5% (15), 61.9% (13), and 62.5% (10) in the HD-tDCS, rTMS, and AD groups, respectively (<em>x</em><sup>2</sup> = 0.002, <em>p</em> = 1.000). Response rates were 66.7% (16), 71.4% (15), and 68.8% (11), respectively, with no significant difference between groups (<em>x</em><sup>2</sup> = 0.12, <em>p</em> = 0.941). All groups demonstrated significant improvement in depressive symptoms and cognitive function. The rTMS group exhibited a significantly greater decrease in Hamilton Depression Scale score compared with the HD-tDCS and AD groups. After 2 weeks of treatment, patients exhibited improved depressive symptoms and reduced activation during the verbal fluency task. However, these changes were not significantly correlated (<em>r</em> = −0.159 to 0.240, <em>p</em> = 0.121–0.988).</div></div><div><h3>Limitations</h3><div>All patients had concomitant use of ADs, which may impact near-infrared spectroscopy signaling and have an indeterminate effect on cognition.</div></div><div><h3>Conclusion</h3><div>HD-tDCS, rTMS, and ADs were equally effective, safe, and well-tolerated. HD-tDCS and rTMS were more effective for working memory, attention, executive functioning, and mood regulation.</div></div>","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 3","pages":"Article 100190"},"PeriodicalIF":3.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-21DOI: 10.1016/j.jnrt.2025.100189
Hongyun Huang , Paul R. Sanberg , Hari Shanker Sharma , Sang Ryong Jeon
{"title":"Developmental phases of Neurorestoratology and current key tasks","authors":"Hongyun Huang , Paul R. Sanberg , Hari Shanker Sharma , Sang Ryong Jeon","doi":"10.1016/j.jnrt.2025.100189","DOIUrl":"10.1016/j.jnrt.2025.100189","url":null,"abstract":"","PeriodicalId":44709,"journal":{"name":"Journal of Neurorestoratology","volume":"13 2","pages":"Article 100189"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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