Journal of Neurorestoratology最新文献_第6页

X-ray-based ultra-high dose rate FLASH radiotherapy mitigates acute radiation-induced hippocampal injury and inflammation 基于x射线的超高剂量率FLASH放疗减轻急性辐射诱导的海马损伤和炎症

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-01-17 DOI: 10.1016/j.jnrt.2025.100186

Renke He , Jiayu Liu , Bingxian Wang , Hanbo Zhang , Shengqiang Xie , Yiyuan Zhang , Xianhong Liu , Jianxin Wang , Dai Wu , Lehui Du , Baolin Qu , Gang Cheng , Jianning Zhang

Background

To compare neural damage induced by ultra-high dose rate FLASH radiotherapy (FLASH-RT) with that induced by conventional dose rate radiotherapy (CONV-RT) in healthy mice.

Methods

Eighty adult male C57BL/6J mice were divided into five groups: Sham, CONV-RT10Gy, CONV-RT20Gy, FLASH-RT10Gy, and FLASH-RT20Gy. Three days post-irradiation, morphological changes in neurons within the dentate gyrus (DG), CA1, and CA3 were observed using hematoxylin and eosin and Nissl staining. The malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), catalase (CAT), and hydroxyl radical (OH⁻) levels were measured using assay kits. Quantitative reverse transcription PCR was used to assess interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF)-α mRNA expression levels in hippocampus. Immunofluorescence was employed to observe microglial activation in the DG.

Results

Compared with Sham, CONV-RT10Gy and CONV-RT20Gy exhibited disorganized neuronal arrangements and blurred nucleoli in the DG; the number of Nissl body was reduced, but FLASH-RT10Gy and FLASH-RT20Gy alleviated these abnormalities. Moreover, FLASH-RT20Gy mitigated the upregulation of MDA and downregulation of GSH, GSH-PX, SOD, CAT, and OH⁻ levels in the hippocampus of mice subjected to CONV-RT20Gy. Additionally, FLASH-RT20Gy attenuated the upregulation of IL-1β, IL-6, iNOS, and TNF-α mRNA levels in hippocampus of mice subjected to CONV-RT20Gy and diminished microglial activation in the DG.

Conclusion

FLASH-RT mitigate the structural and functional disruptions in hippocampal neurons induced by CONV-RT and alleviate oxidative stress and inflammation in hippocampal tissue by reducing microglial activation.

目的比较超高剂量率快闪放疗（FLASH- rt）与常规剂量率放疗（convt）对健康小鼠神经损伤的影响。方法将成年雄性C57BL/6J小鼠80只分为Sham组、con - rt10gy组、con - rt20gy组、FLASH-RT10Gy组和FLASH-RT20Gy组。照射3 d后，采用苏木精染色、伊红染色和尼氏染色观察大鼠齿状回（DG）内神经元及CA1、CA3的形态学变化。用检测试剂盒检测丙二醛（MDA）、还原性谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH- px）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和羟基自由基（OH -）水平。采用定量反转录PCR法检测海马组织中白细胞介素(IL)-1β、IL-6、诱导型一氧化氮合酶（iNOS）和肿瘤坏死因子(TNF)-α mRNA的表达水平。采用免疫荧光法观察DG小胶质细胞的活化情况。结果与Sham相比，convr - rt10gy和convr - rt20gy在DG中表现出神经元排列紊乱和核仁模糊；Nissl小体数量减少，而FLASH-RT10Gy和FLASH-RT20Gy均可缓解这些异常。此外，FLASH-RT20Gy还能减轻rev - rt20gy小鼠海马组织中MDA的上调和GSH、GSH- px、SOD、CAT和OH -水平的下调。此外，FLASH-RT20Gy还能减弱rev - rt20gy小鼠海马中IL-1β、IL-6、iNOS和TNF-α mRNA水平的上调，并降低DG中小胶质细胞的激活。结论flash - rt可减轻convr - rt诱导的海马神经元结构和功能破坏，并通过降低小胶质细胞的激活来减轻海马组织的氧化应激和炎症。

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引用次数: 0

Compound B vitamins mitigate post-traumatic stress disorder-like behaviors induced by single prolonged stress in rats by inhibiting hippocampal mitochondrial DNA methylation 复合B族维生素通过抑制海马线粒体DNA甲基化，减轻大鼠单次长时间应激诱导的创伤后应激障碍样行为

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-01-17 DOI: 10.1016/j.jnrt.2025.100187

Yanteng Li , Runzi Wang , Fang Xie , Lingjia Qian , Yong Zhang , Jianning Zhang

Background

Post-traumatic stress disorder (PTSD) is a serious mental disorder. Current treatments, typically using serotonin reuptake inhibitors, have limited effectiveness and often cause severe adverse effects. In the present study, we investigated whether Compound B vitamins (VBco) have protective effects in improving PTSD-like behaviors and the possible related molecular mechanisms in a rat model of single prolonged stress (SPS).

Methods

Eighty adult male rats were randomly divided into four groups (n = 20): control (CTRL), SPS, VBco control (CTRL-VBco), and SPS and VBco (SPS-VBco). After modeling, behavioral tests (including open field test, forced swimming test, sucrose preference test, fear conditioning test) were conducted. Blood was collected to detect plasma homocysteine (Hcy) concentrations. Brain tissue was collected for mitochondrial function analysis, western blotting, and quantitative real-time Polymerase Chain Reaction (PCR).

Results

VBco reduced plasma Hcy levels significantly 1 week post-SPS. The SPS-VBco group showed decreased grooming times and increased movement speed in the open field test, less resting time in the forced swim test, increased sucrose preference ratios in the sucrose preference test, and less freezing time in the fear conditioning test. VBco increased the expression of mRNA for subunits of respiratory chain-related protein in hippocampal mitochondria and improved mitochondrial complex I and IV activity and membrane potential in hippocampus. VBco reversed SPS-induced mtND1 and mtND3 methylation in hippocampal mitochondria. VBco downregulated the levels of methyltransferases (DNMT1, DNMT3A, DNMT3B) in hippocampal mitochondria.

Conclusion

VBco can inhibit hippocampal mitochondrial DNA methylation effectively. This may be one of the mechanisms by which it attenuates PTSD-like behaviors.

创伤后应激障碍（PTSD）是一种严重的精神障碍。目前的治疗方法，通常使用血清素再摄取抑制剂，效果有限，经常引起严重的不良反应。本研究旨在探讨复合B族维生素（VBco）对单次延长应激（SPS）大鼠创伤后应激样行为的保护作用及其可能的分子机制。方法80只成年雄性大鼠随机分为4组（n = 20）：对照组（CTRL）、SPS + VBco对照组（CTRL-VBco）和SPS + VBco组（SPS-VBco）。建模完成后，进行行为学测试（包括空地测试、强迫游泳测试、蔗糖偏好测试、恐惧条件反射测试）。采集血液检测血浆同型半胱氨酸（Hcy）浓度。采集脑组织进行线粒体功能分析、western blotting和实时定量聚合酶链反应（PCR）。结果vbco可显著降低sps后1周血浆Hcy水平。SPS-VBco组小鼠在开阔场地试验中梳洗次数减少，运动速度加快，在强迫游泳试验中休息时间减少，在蔗糖偏好试验中蔗糖偏好比增加，在恐惧条件反射试验中冻结时间减少。VBco增加了海马线粒体呼吸链相关蛋白亚基mRNA的表达，改善了海马线粒体复合体I和IV的活性和膜电位。VBco逆转了sps诱导的海马线粒体mtND1和mtND3甲基化。VBco下调海马线粒体甲基转移酶（DNMT1、DNMT3A、DNMT3B）水平。结论茯苓多糖可有效抑制海马线粒体DNA甲基化。这可能是它减轻类似创伤后应激障碍行为的机制之一。

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引用次数: 0

Making smiles and eye closure natural! Application of acupoint injection therapy in facial paralysis comorbidities: A case report 让微笑和闭上眼睛变得自然！穴位注射治疗面瘫合并症1例

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-01-11 DOI: 10.1016/j.jnrt.2025.100185

Yuxin Liu , Xixi Han , Lin Chen , Bin Ma

Facial paralysis comorbidities is now understood to include two distinct forms: synkinesis and micro-entrapment syndrome of nerves innervating the face (MESNIF). These disorders manifest as oromandibular synkinesis, stiffness and atrophy of facial muscles on one side, which affect activities of daily living. Acupoint Injection is a treatment for facial paralysis, combining the meridian theory of traditional Chinese medicine, with the injection of specific drugs into acupuncture points of the face. In recent years, the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects. We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.

面瘫的合并症现在被理解为包括两种不同的形式：面部神经联动性和微压迫综合征（MESNIF）。这些疾病表现为单侧面部肌肉僵硬和萎缩，影响日常生活活动。穴位注射是结合中医经络理论，将特定药物注射到面部穴位，治疗面瘫的一种方法。近年来，穴位注射的临床疗效显著，不良反应少。我们报告的情况下，介绍这种综合疗法，并概述康复治疗的关键原则。

引用次数: 0

Neuroanatomical characteristics of late-onset essential tremors: Implications for stereotactic targeting of the ventral intermediate nucleus of the thalamus 迟发性原发性震颤的神经解剖学特征：丘脑腹侧中间核立体定向靶向的意义

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-01-03 DOI: 10.1016/j.jnrt.2024.100178

Junhyung Kim , Sungyang Jo , Sun Ju Chung , Seok Ho Hong , Sang Ryong Jeon

Background

Essential tremor is the most prevalent movement disorder in older adults, yet its association with aging-related anatomical changes has not been well explored. This study aimed to identify the clinical and neuroanatomical characteristics of medically refractory essential tremor in individuals who are potential candidates for surgical intervention.

Methods

We conducted a cross-sectional descriptive analysis of a population with essential tremors at a single tertiary-level center. Morphometric analysis of structural MRI was performed for 96 samples, and volumetric measurements were compared across four age/sex-matched groups (beta-blocker monotherapy, combination therapy, surgical intervention, and healthy controls).

Results

Individuals with essential tremors had greater ventricular volume than healthy controls. The lateral ventricle volume was 1.57-fold (95% confidence interval, 1.39 to 1.77) larger in the essential tremor subjects, while no significant differences between treatment groups were observed. In terms of stereotactic target coordinate of the ventral intermediate nucleus (Vim) of the thalamus, the width of the third ventricle at the intercommissural plane level was 8.0 ± 2.2 mm in the surgical intervention group, compared with 5.7 ± 2.3 mm in healthy controls. The Vim target coordinates averaged 13.8 ± 1.6 mm laterally from the midline in this cohort; however, one-quarter of candidates had coordinates exceeding 16 mm, substantially differing from previously established atlas-based coordinates of the Vim.

Conclusions

Our findings suggest the potential association between late-onset essential tremor and hydrocephalus, which necessitates careful consideration in stereotactic procedures with regard to the anatomical variability of the third ventricle.

特发性震颤是老年人中最常见的运动障碍，但其与衰老相关的解剖学变化的关系尚未得到很好的探讨。本研究旨在确定医学上难治性特发性震颤的临床和神经解剖学特征，这些个体可能是手术干预的潜在候选人。方法我们对一个三级中心的原发性震颤人群进行了横断面描述性分析。对96个样本进行了结构MRI形态学分析，并比较了四个年龄/性别匹配组（受体阻滞剂单一治疗、联合治疗、手术干预和健康对照组）的体积测量结果。结果原发性震颤患者的心室容积大于健康对照组。特发性震颤组的侧脑室容积为特发性震颤组的1.57倍（95%可信区间1.39 ~ 1.77），但两组间无显著差异。在丘脑腹侧中间核（Vim）立体定向靶坐标方面，手术干预组第三脑室在节间平面水平的宽度为8.0±2.2 mm，而健康对照组为5.7±2.3 mm。在该队列中，Vim靶坐标平均距中线13.8±1.6 mm；然而，四分之一的候选坐标超过16毫米，与先前建立的基于地图集的Vim坐标有很大不同。结论研究结果提示迟发性特发性震颤与脑积水之间存在潜在的关联，在立体定向手术中需要仔细考虑第三脑室的解剖变异。

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引用次数: 0

Bioinformatic identification of risk factors from an immunological viewpoint in idiopathic Parkinson's disease 从免疫学角度对特发性帕金森病危险因素的生物信息学鉴定

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2025-01-03 DOI: 10.1016/j.jnrt.2024.100177

Zhenshan Sun , Pengfei Fu , Shiqing Zhang , Ken Kin Lam Yung

Background

In the present study, we focused on uncovering stable genetic alterations associated with idiopathic Parkinson's disease (IPD) in blood samples. We aimed to identify factors that connect IPD to the peripheral immune system, thereby deepening our understanding of the pathophysiology of this disease.

Methods

A gene expression microarray dataset (GSE99039) was selected from the National Center for Biotechnology Information Gene Expression Omnibus database to screen for differentially expressed genes (DEGs). Subsequent analyses included Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. A protein–protein interaction network was then constructed to identify hub genes within these DEGs. Additionally, we used a verification dataset (GSE160299) to test the consistency of the expression level changes of the hub genes.

Results

We identified 277 DEGs, comprising 270 downregulated genes and 7 upregulated genes. The functional enrichment results revealed a close association between IPD and changes in peripheral immune status. Five hub genes—HLA-F, HLA-E, KIR3DL2, KIR3DL1, and TYROBP—were identified, and the expression level changes remained stable in the verification set.

Conclusions

Our findings help to clarify the regulatory pathways that connect peripheral immunity to IPD pathogenesis. We identified five key hub genes in the blood as IPD-related factors; all five genes were also significantly altered in an independent clinical dataset.

在本研究中，我们的重点是揭示血液样本中与特发性帕金森病（IPD）相关的稳定遗传改变。我们的目标是确定将IPD与外周免疫系统联系起来的因素，从而加深我们对这种疾病的病理生理学的理解。方法从国家生物技术信息中心基因表达综合数据库中选择基因表达微阵列数据集（GSE99039）筛选差异表达基因（DEGs）。随后的分析包括基因本体和京都基因和基因组百科全书途径富集分析。然后构建了一个蛋白质-蛋白质相互作用网络来鉴定这些deg中的中心基因。此外，我们使用验证数据集（GSE160299）来测试枢纽基因表达水平变化的一致性。结果共鉴定出277个基因，其中下调基因270个，上调基因7个。功能富集结果显示IPD与外周免疫状态的变化密切相关。鉴定出hla - f、HLA-E、KIR3DL2、KIR3DL1和tyrobp 5个枢纽基因，在验证集中表达水平变化保持稳定。结论sour的发现有助于阐明外周免疫与IPD发病机制之间的调控通路。我们确定了血液中与ipd相关的五个关键枢纽基因；在一个独立的临床数据集中，所有五个基因也发生了显著改变。

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引用次数: 0

Advancements in neurodegenerative diseases: Pathogenesis and novel neurorestorative interventions 神经退行性疾病的进展：发病机制和新的神经修复干预措施

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2024-12-22 DOI: 10.1016/j.jnrt.2024.100176

Wenyong Gao , Shiyuan Jing , Chao He , Hooshang Saberi , Hari Shanker Sharma , Fabin Han , Lin Chen

Progressive neurodegenerative diseases (NDs) that lack effective disease-modifying treatments, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), represent significant global health challenges. In recent years, key research findings have included the role of neuroinflammation driven by microglia and astrocytes, the impact of genetic mutations, and the importance of autophagy and mitochondrial quality control in maintaining neuronal health. In this review, we summarize recent advancements of the pathogenesis of NDs, the cellular and animal models that have provided valuable insights into disease mechanisms, and the development of blood-based biomarkers for early diagnosis and monitoring of disease progression. We also highlight emerging neurorestorative therapeutic strategies involving stem cell therapy, antisense oligonucleotides, and induced pluripotent stem cells. Additionally, we cover recent clinical trials of promising drugs, such as lecanemab and donanemab for AD, and tavapadon for PD. Finally, we propose future research directions, emphasizing the need for combination therapies that target multiple pathways, the development of more precise animal models, and the integration of nanotechnology for improved drug delivery across the blood–brain barrier.

进行性神经退行性疾病（ndds）缺乏有效的疾病改善治疗，包括阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）和亨廷顿病（HD），是全球健康面临的重大挑战。近年来，主要研究成果包括小胶质细胞和星形胶质细胞驱动的神经炎症的作用、基因突变的影响以及自噬和线粒体质量控制在维持神经元健康中的重要性。在这篇综述中，我们总结了NDs发病机制的最新进展，为疾病机制提供有价值见解的细胞和动物模型，以及用于早期诊断和监测疾病进展的基于血液的生物标志物的发展。我们还强调了新兴的神经修复治疗策略，包括干细胞治疗、反义寡核苷酸和诱导多能干细胞。此外，我们还介绍了最近有希望的药物的临床试验，如治疗AD的lecanemab和donanemab，以及治疗PD的tavapadon。最后，我们提出了未来的研究方向，强调需要针对多种途径的联合治疗，开发更精确的动物模型，以及整合纳米技术来改善血脑屏障的药物传递。

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引用次数: 0

Multimodal MRI and artificial intelligence: Shaping the future of glioma 多模态MRI和人工智能：塑造胶质瘤的未来

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2024-12-12 DOI: 10.1016/j.jnrt.2024.100175

Yiqin Yan , Chenxi Yang , Wensheng Chen , Zhaoxing Jia , Haiying Zhou , Zhong Di , Longbiao Xu

Gliomas are the most common malignant tumors in the central nervous system and are known for their inherent diversity and propensity to invade surrounding tissue. These features pose significant challenges in diagnosing and treating these tumors. Magnetic resonance imaging (MRI) has not only remained at the forefront of glioma management but has also evolved significantly with the advent of multimodal MRI. The rise of multimodal MRI represents a pivotal leap forward, as it seamlessly integrates diverse MRI sequences and advanced techniques to offer an unprecedented, comprehensive, and multidimensional glimpse into the complexities of glioma pathology, including encompassing structural, functional, and even molecular imaging. This holistic approach empowers clinicians with a deeper understanding of tumor characteristics, enabling more precise diagnoses, tailored treatment strategies, and enhanced monitoring capabilities, ultimately improving patient outcomes. Looking ahead, the integration of artificial intelligence (AI) with MRI data heralds a new era of unparalleled precision in glioma diagnosis and therapy. This integration holds the promise to revolutionize the field, enabling more sophisticated analyses that fully leverage all aspects of multimodal MRI. In summary, with the continuous advancement of multimodal MRI techniques and future deep integrations with artificial intelligence, glioma care is poised to evolve toward increasingly personalized, precise, and efficacious strategies.

胶质瘤是中枢神经系统中最常见的恶性肿瘤，以其固有的多样性和侵犯周围组织的倾向而闻名。这些特征对这些肿瘤的诊断和治疗提出了重大挑战。磁共振成像（MRI）不仅一直处于胶质瘤治疗的前沿，而且随着多模态MRI的出现也有了显著的发展。多模态MRI的兴起代表了一个关键的飞跃，因为它无缝地集成了不同的MRI序列和先进的技术，为胶质瘤病理的复杂性提供了前所未有的，全面的，多维的一瞥，包括包括结构，功能，甚至分子成像。这种整体方法使临床医生能够更深入地了解肿瘤特征，从而实现更精确的诊断，量身定制的治疗策略和增强的监测能力，最终改善患者的治疗效果。展望未来，人工智能（AI）与MRI数据的整合预示着胶质瘤诊断和治疗无与伦比的精确度的新时代。这种整合有望彻底改变该领域，实现更复杂的分析，充分利用多模态MRI的各个方面。综上所述，随着多模态MRI技术的不断进步以及未来与人工智能的深度融合，胶质瘤治疗将朝着越来越个性化、精确和有效的策略发展。

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引用次数: 0

Clinical association of habitual breakfast skipping with cognitive decline and neurodegeneration among older adults 老年人习惯性不吃早餐与认知能力下降和神经退行性变的临床关系

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2024-11-30 DOI: 10.1016/j.jnrt.2024.100173

Jun Zhang , Ya-Jun Li , Shu Yang , Bing-Hu Li , Duo-Zi Wang , Lei Liu , Jian-Hong Wang

Background

Unhealthy lifestyles have a considerable impact on the incidence of dementia. Skipping breakfast disturbs energy homeostasis and impairs brain function. In this study, we investigated the association between breakfast skipping and cognitive performance among community-dwelling adults.

Methods

We recruited 859 community-dwelling adults aged ≥60 years from January 1 to December 31, 2021. Participants’ sociodemographic information and breakfast skipping habits were self-reported. Participants were followed up for 36 months and cognitive function was assessed using the Mini-Mental State Examination (MMSE) with an interval of 18 months. Trajectories of cognitive change were compared between individuals with and without breakfast skipping. To reduce the risk of bias owing to unmatched sample sizes between the groups, we conducted 1:1 propensity score matching (PSM) based on age, sex, education level, and ApoE genotype.

Results

At baseline and 18-month follow-up, no difference was found in MMSE scores between participants with and without breakfast skipping. However, those who habitually skipped breakfast had significantly lower MMSE scores than those who did not at 36-month follow-up. Individuals with habitual breakfast skipping had a steeper rate of cognitive decline than those without habitual breakfast skipping during follow-up. Breakfast skipping was a risk factor for longitudinal cognitive decline, defined as a decrease in MMSE scores of ≥3, adjusted for age, sex, education, body mass index, ApoE ε4 carrier status, hypertension, diabetes, and hyperlipidemia. At the last follow-up, participants who habitually skipped breakfast had significantly higher levels of ptau181 and NfL than those who did not. In the PSM cohort, similar findings were obtained regarding cognitive trajectories and plasma biomarkers.

Conclusion

Breakfast skipping was linked to an increased risk of long-term cognitive decline and neurodegeneration among older adults. The link between unhealthy dietary habits and cognitive decline may be attributed to a deficiency in neurorestoration resulting from inadequate energy consumption.

健康的生活方式对痴呆症的发病率有相当大的影响。不吃早餐会扰乱能量平衡，损害大脑功能。在这项研究中，我们调查了在社区居住的成年人中不吃早餐与认知表现之间的关系。方法于2021年1月1日至12月31日招募859名年龄≥60岁的社区居民。参与者的社会人口统计信息和不吃早餐的习惯是自我报告的。参与者随访36个月，并使用间隔18个月的迷你精神状态检查（MMSE）评估认知功能。研究人员比较了不吃早餐和不吃早餐的人的认知变化轨迹。为了减少由于组间样本量不匹配而导致的偏倚风险，我们基于年龄、性别、教育水平和ApoE基因型进行了1:1的倾向评分匹配（PSM）。结果在基线和18个月的随访中，不吃早餐和不吃早餐的参与者的MMSE评分没有差异。然而，在36个月的随访中，那些习惯性不吃早餐的人的MMSE得分明显低于不吃早餐的人。在随访期间，习惯性不吃早餐的个体认知能力下降的速度比没有习惯性不吃早餐的个体要快。不吃早餐是纵向认知能力下降的危险因素，定义为MMSE评分≥3，调整年龄、性别、教育程度、体重指数、ApoE ε4携带者状态、高血压、糖尿病和高脂血症。在最后一次随访中，习惯性不吃早餐的参与者的ptau181和NfL水平明显高于不吃早餐的参与者。在PSM队列中，在认知轨迹和血浆生物标志物方面获得了类似的发现。结论：不吃早餐与老年人长期认知能力下降和神经变性的风险增加有关。不健康的饮食习惯和认知能力下降之间的联系可能归因于能量消耗不足导致的神经恢复不足。

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引用次数: 0

Analysis of causal relationship between immune cells and intracranial aneurysm: A mendelian randomization study 免疫细胞与颅内动脉瘤的因果关系分析：孟德尔随机化研究

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2024-11-15 DOI: 10.1016/j.jnrt.2024.100168

Yang Zhang , Sifei Wang , Yiming Huang , Miaowen Jiang , Baoying Song , Di Wu , Ming Wei , Ming Li , Xunming Ji

Background

Immune cells have been detected in intracranial aneurysms (IAs). However, the causal effect of immune cell phenotypes on IAs remains unclear and difficult to comprehensively analyze.

Methods

Instrumental variables for 731 immunophenotypes were extracted from publicly available genetic databases. The influence of these immune cell traits on IAs was evaluated using the Mendelian randomization (MR) method. Five MR analysis methods, with inverse-variance-weighted as the main method, along with a comprehensive sensitivity analysis, were used to determine reliability of the results. Multivariable MR analysis was performed to correct for interactions between different immune cell phenotypes.

Results

Overall, 27 immune cell traits exhibited significant causal effects on IAs. Among them, 13 immunophenotypes increased the risk of IA progression. Conversely, 14 immune cell characteristics might protect against IAs. Following false discovery rate correction, two hazardous and three protective immunophenotypes remained significant. Moreover, multivariate MR analysis showed that only naive CD4− CD8− T cells %T cells remained causally associated with a risk of IA, while CD19 on IgD+ CD38− naive B cells inhibited development of IAs.

Conclusions

Our study shows that immune cell traits and IAs are causally correlated, providing a new theoretical framework for understanding immune-IA crosstalk.

背景在颅内动脉瘤（IAs）中发现了免疫细胞。方法从公开的遗传数据库中提取了 731 种免疫表型的工具变量。采用孟德尔随机化（MR）方法评估了这些免疫细胞性状对IAs的影响。以反方差加权法为主要方法的五种 MR 分析方法以及全面的敏感性分析被用来确定结果的可靠性。进行了多变量 MR 分析，以校正不同免疫细胞表型之间的相互作用。其中，13种免疫表型增加了IA进展的风险。相反，有 14 种免疫细胞特征可预防原发性心肌梗死。经误诊率校正后，两种危险性免疫表型和三种保护性免疫表型仍具有显著性。此外，多变量 MR 分析表明，只有天真 CD4- CD8- T 细胞 %T 细胞仍与 IA 风险存在因果关系，而 IgD+ CD38- 天真 B 细胞上的 CD19 可抑制 IA 的发展。

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引用次数: 0

Authors’ response to correspondence regarding “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review” 作者对有关 "脑深部刺激和经颅磁刺激在中风神经恢复中的应用：综述"

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neurorestoratology

Pub Date : 2024-10-22 DOI: 10.1016/j.jnrt.2024.100161

Yanxi Chen, Wen Wang, Fangling Sun

引用次数: 0