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Patient Specific Vascular Benchtop Models for Development and Validation of Medical Devices for Minimally Invasive Procedures 用于微创手术的医疗器械开发和验证的患者特异性血管台式模型
Pub Date : 2016-09-27 DOI: 10.1142/S2424905X16400080
Maryna Kvasnytsia, N. Famaey, M. Böhm, E. Verhoelst
Using realistic benchtop models in early stages of device development can reduce time and efforts necessary to move the device to further testing. In this study, we propose several patient specific vascular benchtop models for the development and validation of a robotic catheter for transcatheter aortic valve implantation. The design and manufacturing of these models, and their properties are presented. Additionally, it is demonstrated that the described design process provides virtual models that are accurately linked to the physical models.
在设备开发的早期阶段使用真实的台式模型可以减少将设备移动到进一步测试所需的时间和精力。在这项研究中,我们提出了几个患者特定的血管台式模型,用于开发和验证经导管主动脉瓣植入术的机器人导管。介绍了这些模型的设计、制造和性能。此外,还证明了所描述的设计过程提供了与物理模型精确链接的虚拟模型。
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引用次数: 3
Intuitive Control Strategies for Teleoperation of Active Catheters in Endovascular Surgery 血管内手术中活动导管遥操作的直观控制策略
Pub Date : 2016-09-27 DOI: 10.1142/S2424905X16400122
A. Devreker, P. T. Tran, Benoît Rosa, H. Praetere, Nicolai Häni, N. Famaey, D. Seatovic, P. Herijgers, J. Sloten, D. Reynaerts, E. V. Poorten
Cardiovascular surgeons increasingly resort to catheter-based diagnostic and therapeutic interventions because of their limited invasiveness. Although, these approaches allow treatment of patients considered unfit for conventional open surgery, exposure to radiation and high procedural complexity could lead to complications. These factors motivated the introduction of robotic technology offering more dexterous catheters, enhanced visualization and opening new possibilities in terms of guidance and coordinated control. In addition to improvements of patient outcome, through teleoperated catheter control radiation exposure of surgeons can be reduced. In order to limit surgical workload, intuitive mappings between joystick input and resulting catheter motion are essential. This paper presents and compares two proposed mappings and investigates the benefits of additional visual guidance. The comparison is based on data gathered during an experimental campaign involving 14 novices and three surgeons. The participants were asked to perform an endovascular task in a virtual reality simulator presented in the first part of this paper. Statistical results show significant superiority of one mapping with respect to the other and a significant improvement of performance thanks to additional visual guidance. Future work will focus on translating the results to a physical setup for surgical validation, also the learning effect will be analyzed more in-depth.
心血管外科医生越来越多地求助于基于导管的诊断和治疗干预,因为它们的侵入性有限。虽然这些方法可以治疗不适合传统开放手术的患者,但暴露于辐射和高度的程序复杂性可能导致并发症。这些因素推动了机器人技术的引入,提供了更灵巧的导管,增强了可视化,并在引导和协调控制方面开辟了新的可能性。除了改善患者预后外,通过远程操作导管控制可以减少外科医生的辐射暴露。为了限制手术工作量,操纵杆输入和由此产生的导管运动之间的直观映射是必不可少的。本文提出并比较了两种建议的映射,并研究了附加视觉引导的好处。这一对比是基于一项涉及14名新手和3名外科医生的实验活动中收集的数据。参与者被要求在本文第一部分介绍的虚拟现实模拟器中执行血管内任务。统计结果表明,一种映射相对于另一种映射具有显着的优越性,并且由于额外的视觉引导,性能得到了显着改善。未来的工作将侧重于将结果转化为手术验证的物理设置,并且将更深入地分析学习效果。
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引用次数: 4
A Survey on the Current Status and Future Challenges Towards Objective Skills Assessment in Endovascular Surgery 血管内外科客观技能评价的现状及未来挑战
Pub Date : 2016-09-27 DOI: 10.1142/S2424905X16400109
E. Mazomenos, Ping-Lin Chang, A. Rolls, D. Hawkes, C. Bicknell, E. V. Poorten, C. Riga, A. Desjardins, D. Stoyanov
Minimally invasive endovascular interventions have evolved rapidly over the past decade, facilitated by breakthroughs in medical imaging and sensing, instrumentation and most recently robotics. Catheter-based operations are potentially safer and applicable to a wider patient population due to the reduced comorbidity. As a result endovascular surgery has become the preferred treatment option for conditions previously treated with open surgery and as such the number of patients undergoing endovascular interventions is increasing every year. This fact coupled with a proclivity for reduced working hours results in a requirement for efficient training and assessment of new surgeons, that deviates from the “see one, do one, teach one” model introduced by William Halsted, so that trainees obtain operational expertise in a shorter period. Developing more objective assessment tools based on quantitative metrics is now a recognized need in interventional training and this manuscript reports the current literature for endovascular skills assessment and the associated emerging technologies. A systematic search was performed on PubMed (MEDLINE), Google Scholar, IEEXplore and known journals using the keywords, “endovascular surgery”, “surgical skills”, “endovascular skills”, “surgical training endovascular” and “catheter skills”. Focusing explicitly on endovascular surgical skills, we group related works into three categories based on the metrics used; structured scales and checklists, simulation-based and motion-based metrics. This review highlights the key findings in each category and also provides suggestions for new research opportunities towards fully objective and automated surgical assessment solutions.
在过去十年中,由于医学成像和传感、仪器仪表以及最近的机器人技术的突破,微创血管内介入技术发展迅速。基于导管的手术可能更安全,并且由于减少了合并症而适用于更广泛的患者群体。因此,血管内手术已成为先前以开放手术治疗的疾病的首选治疗选择,因此,接受血管内介入治疗的患者数量每年都在增加。这一事实与减少工作时间的倾向相结合,导致对新外科医生进行有效培训和评估的需求,这偏离了威廉·霍尔斯特德(William Halsted)提出的“看一个,做一个,教一个”模式,以便学员在更短的时间内获得操作专业知识。基于定量指标开发更客观的评估工具是介入训练中公认的需求,本文报告了血管内技能评估和相关新兴技术的当前文献。系统检索PubMed (MEDLINE)、Google Scholar、IEEXplore及已知期刊,检索关键词为“endovascular surgery”、“surgical skills”、“endovascular skills”、“surgical training endovascular”、“catheter skills”。明确关注血管内手术技能,我们根据使用的指标将相关工作分为三类;结构化的尺度和清单,基于模拟和基于动作的指标。这篇综述强调了每个类别的关键发现,并为实现完全客观和自动化的手术评估解决方案提供了新的研究机会。
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引用次数: 8
Restoring Haptic Feedback in NOTES Procedures with a Novel Wireless Tissue Stiffness Probe 用一种新型无线组织刚度探头在NOTES程序中恢复触觉反馈
Pub Date : 2016-06-13 DOI: 10.1142/S2424905X16500021
M. Beccani, C. Natali, P. Valdastri, K. Obstein
In the past two decades, several instruments have been developed to overcome the loss of haptic sensation in minimally invasive surgery (MIS). Unfortunately, none of the proposed instruments has been clinically adopted or utilized in natural orifice translumenal endoscopic surgery (NOTES) procedures. The challenge is that NOTES instruments require mounting upon flexible endoscopes thus altering endoscope flexibility and dexterity. We have developed a novel wireless tissue stiffness probe (WTSP) that can be used with a flexible endoscope and create a real-time stiffness distribution map with potential to restore haptic sensation in NOTES. The aim of our study was to assess the performance and feasibility of the WTSP in an ex vivo trial (three phantom models of different elasticity; comparing discrimination of human touch with the WTSP) and in an in vivo trans-colonic access NOTES procedure. Overall, the WTSP was able to detect the stiffness of the three phantoms with a relative error smaller than 3% and a success rate of 100% versus 95% when compared to human perception. The novel WTSP was successful in providing the operator with tactile and kinesthetic feedback for accurate discrimination between tissue phantoms. In vivo tissue palpation was feasible using the WTSP in a trans-colonic NOTES procedure. The WTSP did not encumber the maneuverability or dexterity of the flexible endoscope. This innovative approach to tissue palpation has the potential to open a new paradigm in the field of NOTES where no mechanical link between the external platform and the target region exists.
在过去的二十年中,已经开发了几种仪器来克服微创手术(MIS)中触觉的丧失。不幸的是,没有一种建议的器械被临床采用或用于自然孔口腔内内镜手术(NOTES)程序。挑战在于NOTES仪器需要安装在灵活的内窥镜上,从而改变内窥镜的灵活性和灵活性。我们开发了一种新型的无线组织刚度探头(WTSP),可以与柔性内窥镜一起使用,并创建实时刚度分布图,有可能恢复NOTES中的触觉感觉。我们研究的目的是在离体试验中评估WTSP的性能和可行性(三种不同弹性的假体模型;比较人的触摸与WTSP的歧视)和在体内的跨结肠进入NOTES程序。总的来说,与人类感知相比,WTSP能够以小于3%的相对误差检测三种幻影的刚度,成功率为100%,而不是95%。新的WTSP成功地为操作者提供了触觉和动觉反馈,以准确区分组织幻象。在经结肠NOTES手术中使用WTSP进行体内组织触诊是可行的。WTSP不妨碍灵活内窥镜的机动性和灵活性。这种创新的组织触诊方法有可能在外部平台和目标区域之间没有机械联系的NOTES领域开辟新的范例。
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引用次数: 2
Nonlinear Force Feedback Enhancement for Cooperative Robotic Neurosurgery Enforces Virtual Boundaries on Cortex Surface 协作机器人神经外科手术的非线性力反馈增强强化皮层表面的虚拟边界
Pub Date : 2016-06-13 DOI: 10.1142/S2424905X1650001X
Elisa Beretta, G. Ferrigno, E. Momi
Surgeons can benefit from the cooperation with a robotic assistant during the repetitive execution of precise targeting tasks on soft tissues, such as brain cortex stimulation procedures in open-skull neurosurgery. Position-based force-to-motion control schemes may not be satisfactory solution to provide the manipulator with the high compliance desirable during guidance along wide trajectories. A new torque controller with nonlinear force feedback enhancement (FFE) is presented to provide augmented haptic perception to the operator from instrument-tissue interaction. Simulation tests were performed to evaluate the system stability according to different nonlinear force modulation functions (power, sigmoidal and arc tangent). The FFE controller with power modulation was experimentally validated with a pool of nonexpert users using brain-mimicking gelatin phantoms (8–16% concentration). Besides providing hand tremor rejection for a stable holding of the tool, the FFE controller was proven to allow for a safer tissue contact with respect to both robotic assistance without force feedback and freehand executions (50% and 75% reduction of the indentation depth, respectively). Future work will address the evaluation of the safety features of the FFE controller with expert surgeons on a realistic brain phantom, also accounting for unpredictable tissue motions as during seizures due to cortex stimulation.
外科医生可以在重复执行软组织精确定位任务时受益于机器人助手的合作,例如开颅神经外科中的脑皮层刺激程序。基于位置的力-运动控制方案可能不是一个令人满意的解决方案,以提供机械臂在沿宽轨迹制导时所需的高顺应性。提出了一种新型的非线性力反馈增强力矩控制器,从仪器与组织的相互作用中为操作者提供增强的触觉感知。根据不同的非线性力调制函数(幂函数、s形函数和弧切函数)进行了系统稳定性仿真试验。具有功率调制的FFE控制器通过使用模拟大脑的明胶模型(浓度为8-16%)的非专家用户池进行了实验验证。除了为稳定持有工具提供手部震颤抑制外,FFE控制器还被证明可以在没有力反馈的机器人辅助和徒手执行方面实现更安全的组织接触(分别减少50%和75%的压痕深度)。未来的工作将与专家外科医生一起对FFE控制器的安全性进行评估,同时考虑到癫痫发作期间由于皮质刺激导致的不可预测的组织运动。
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引用次数: 3
A Compact Telemanipulated Retinal-Surgery System that Uses Commercially Available Instruments with a Quick-Change Adapter 一个紧凑的远程操作视网膜手术系统,使用市售仪器与快速更换适配器
Pub Date : 2016-06-13 DOI: 10.1142/S2424905X16300016
M. Nambi, P. Bernstein, J. Abbott
We present a telemanipulation system for retinal surgery that uses a full range of unmodified commercially available instruments. The system is compact and light enough that it could reasonably be made head-mounted to passively compensate for head movements. Two mechanisms are presented that enable the system to use commercial actuated instruments, and an instrument adapter enables quick-change of instruments during surgery. A custom stylus for a haptic interface enables intuitive and ergonomic telemanipulation of actuated instruments. Experimental results with a force-sensitive phantom eye show that telemanipulated surgery results in reduced forces on the retina compared to manual surgery, and training with the system results in improved performance.
我们提出了一个远程操作系统的视网膜手术,使用全系列的未经修改的商用仪器。该系统结构紧凑,重量轻,可以合理地制作为头戴式,以被动补偿头部运动。提出了两种机制,使系统能够使用商业驱动的器械,并且器械适配器可以在手术期间快速更换器械。自定义触控笔的触觉界面,使直观和符合人体工程学的遥控驱动的仪器。力敏感幻眼的实验结果表明,与手动手术相比,远程操作手术可以减少视网膜上的力,并且使用该系统进行训练可以提高性能。
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引用次数: 20
Nonrigid Registration of Pre-Procedural MRI and Intra-Procedural CT in CT-Guided Cryoablation of Lung Tumors to Improve Lung Tumor Conspicuity CT引导下肺肿瘤冷冻消融术前MRI和术中CT的非刚性配准以改善肺肿瘤的显著性
Pub Date : 2016-06-13 DOI: 10.1142/S2424905X16500045
N. Hata, S. Tatli, A. Yamada, O. Olubiyi, S. Silverman
To improve lung tumor conspicuity during CT-guided cryoablations, we used nonrigid image registrations to fuse pre-procedural MR images and intra-procedural CT images and determined which set of CT images taken at planning, targeting, and monitoring phases of the procedure provided the most accurate and fastest registrations. In 10 percutaneous CT-guided cryoablation procedures, MR images were registered with intra-procedural CT images using a nonrigid registration technique using an intensity-based approach with affine and B-Spline transformations. The time to complete the registration as well as the accuracy of the registration defined by Target Registration Error (TRE), Dice Similarity Coefficient (DSC), and Hausdorff Distance (HD) were measured to assess the performance of the registration. The least significant difference (LSD) method was used as a post-hoc analysis for comparing time and accuracy among planning, targeting, and monitoring phases. The mean TRE of the registration ranged from 6.26 (planning) to 10.31 (monitoring) mm. The mean DSC ranged from 83.86 (monitoring) to 89.22 (planning). The mean HD values ranged from 7.74 (targeting) to 12.20 (monitoring). Mean registration time ranged from 68.67 (monitoring) to 92.02 (planning) s. Using HD, registrations in either the planning or targeting phase were more accurate than in the monitoring phase. The registration was faster using monitoring images than using planning images. Nonrigid registration techniques can be used to fuse pre-procedural MR images with intra-procedural CT images with varying performance depending on the CT images taken at the different phases of the procedure. Therefore, caution should be taken in setting expectations on accuracies and speeds of registration depending on the phases of the CT-guided ablation procedures.
为了提高CT引导下冷冻消融过程中肺肿瘤的显著性,我们使用非刚性图像配准来融合术前MR图像和术中CT图像,并确定在手术的计划、靶向和监测阶段拍摄的哪组CT图像提供了最准确和最快的配准。在10例经皮CT引导下的冷冻消融手术中,采用基于强度的仿射和b样条变换方法,使用非刚性配准技术将MR图像与术中CT图像进行配准。通过测量目标配准误差(Target registration Error, TRE)、骰子相似系数(Dice Similarity Coefficient, DSC)和豪斯多夫距离(Hausdorff Distance, HD)定义的配准精度以及完成配准的时间来评估配准的性能。采用最小显著差异(LSD)法进行事后分析,比较计划阶段、目标阶段和监测阶段的时间和准确性。登记的平均TRE范围为6.26(计划)至10.31(监测)mm。平均DSC范围为83.86(监测)至89.22(计划)。平均HD值从7.74(目标)到12.20(监测)不等。平均配准时间从68.67 s(监测)到92.02 s(计划)不等。使用HD,无论是计划阶段还是目标阶段的配准都比监测阶段更准确。使用监控映像比使用规划映像的配准速度更快。非刚性配准技术可用于融合程序前MR图像和程序内CT图像,这些图像的性能取决于在程序的不同阶段拍摄的CT图像。因此,根据ct引导消融过程的不同阶段,在设定精度和速度的期望时应谨慎。
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引用次数: 0
Three-Dimensional Needle Steering Using Automated Breast Volume Scanner (ABVS) 利用自动乳腺体积扫描仪(ABVS)进行三维针导向
Pub Date : 2016-04-05 DOI: 10.1142/S2424905X16400055
M. Abayazid, P. Moreira, Navid Shahriari, Anastasios Zompas, S. Misra
Robot-assisted and ultrasound-guided needle insertion systems assist in achieving high targeting accuracy for different applications. In this paper, we introduce the use of Automated Breast Volume Scanner (ABVS) for scanning different soft tissue phantoms. The ABVS is a commercial ultrasound transducer used for clinical breast scanning. A preoperative scan is performed for three-dimensional (3D) target localization and shape reconstruction. The ultrasound transducer is also adapted to be used for tracking the needle tip during steering toward the localized targets. The system uses the tracked needle tip position as a feedback to the needle control algorithm. The bevel-tipped flexible needle is steered under ABVS guidance toward a target while avoiding an obstacle embedded in soft tissue phantom. We present experimental results for 3D reconstruction of different convex and non-convex objects with different sizes. Mean Absolute Distance (MAD) and Dice’s coefficient methods are used to evaluate the 3D shape reconstruction algorithm. The results show that the mean MAD values are 0.30±0.13mm and 0.34±0.17mm for convex and non-convex shapes, respectively, while mean Dice values are 0.87±0.06 (convex) and 0.85±0.06 (non-convex). Three experimental cases are performed to validate the steering system. Mean targeting errors of 0.54±0.24, 1.50±0.82 and 1.82±0.40mm are obtained for steering in gelatin phantom, biological tissue and a human breast phantom, respectively. The achieved targeting errors suggest that our approach is sufficient for targeting lesions of 3mm radius that can be detected using clinical ultrasound imaging systems.
机器人辅助和超声引导的针头插入系统有助于实现不同应用的高瞄准精度。在本文中,我们介绍了使用自动乳腺体积扫描仪(ABVS)扫描不同的软组织幻象。ABVS是一种商用超声换能器,用于临床乳房扫描。术前扫描进行三维(3D)目标定位和形状重建。超声换能器还适于用于在转向局部目标期间跟踪针尖。该系统使用跟踪的针尖位置作为对针控算法的反馈。斜尖柔性针在ABVS引导下朝向目标,同时避开嵌入软组织幻影中的障碍物。我们给出了不同尺寸的凸和非凸物体的三维重建实验结果。采用平均绝对距离法和Dice系数法对三维形状重建算法进行了评价。结果表明,凸型和非凸型的MAD平均值分别为0.30±0.13mm和0.34±0.17mm, Dice平均值分别为0.87±0.06(凸型)和0.85±0.06(非凸型)。通过三个实验案例对转向系统进行了验证。在明胶模型、生物组织模型和人类乳房模型中获得的平均瞄准误差分别为0.54±0.24、1.50±0.82和1.82±0.40mm。所获得的靶向误差表明,我们的方法足以靶向3mm半径的病变,可以使用临床超声成像系统检测到。
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引用次数: 11
Ultrasound-Based Image Guidance and Motion Compensating Control for Robot-Assisted Beating-Heart Surgery 机器人辅助心脏手术的超声图像引导和运动补偿控制
Pub Date : 2016-04-05 DOI: 10.1142/S2424905X1640002X
Meaghan Bowthorpe, M. Tavakoli
Performing a surgical task on a beating heart requires superhuman skill as the surgeon must manually track the heart’s motion while performing a surgical task. However, the ability to operate on a beating heart would eliminate the need to use a mechanical stabilizer or arrest the heart and connect the patient to a heart-lung machine and would consequently eliminate their side effects. This work develops the image processing and control structure for an ultrasound-guided robot-assisted beating heart surgical system that will move the surgical tool tip in synchrony with the heart. This would allow the surgeon to operate through teleoperation on a virtually stabilized point on the heart. In developing this system, the position data acquired from ultrasound images is upsampled and predicted ahead to compensate for the image acquisition and processing delay. We present the results of a user task based on mitral valve annuloplasty performed under ultrasound guidance.
对跳动的心脏进行手术需要超人的技能,因为外科医生在执行手术任务时必须手动跟踪心脏的运动。然而,对跳动的心脏进行手术的能力将消除使用机械稳定器或停止心脏并将患者连接到心肺机的需要,从而消除它们的副作用。这项工作开发了超声引导机器人辅助心脏手术系统的图像处理和控制结构,该系统将与心脏同步移动手术工具尖端。这将允许外科医生通过远程手术对心脏上一个几乎稳定的点进行操作。在开发该系统时,从超声图像中获取的位置数据被上采样并提前预测,以补偿图像采集和处理的延迟。我们提出了一个基于超声引导下二尖瓣成形术的用户任务的结果。
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引用次数: 8
Needle Tracking and Deflection Prediction for Robot-Assisted Needle Insertion Using 2D Ultrasound Images 基于二维超声图像的机器人辅助插针跟踪和偏转预测
Pub Date : 2016-04-05 DOI: 10.1142/S2424905X16400018
M. Waine, C. Rossa, R. Sloboda, N. Usmani, M. Tavakoli
In many types of percutaneous needle insertion surgeries, tissue deformation and needle deflection can create significant difficulties for accurate needle placement. In this paper, we present a method for automatic needle tracking in 2D ultrasound (US) images, which is used in a needle–tissue interaction model to estimate current and future needle tip deflection. This is demonstrated using a semi-automatic needle steering system. The US probe can be controlled to follow the needle tip or it can be stopped at an appropriate position to avoid tissue deformation of the target area. US images are used to fully parameterize the needle-tissue model. Once the needle deflection reaches a pre-determined threshold, the robot rotates the needle to correct the tip’s trajectory. Experimental results show that the final needle tip deflection can be estimated with average accuracies between 0.7mm and 1.0mm for insertions with and without rotation. The proposed method provides surgeons with improved US feedback of the needle tip deflection and minimizes the motion of the US probe to reduce tissue deformation of the target area.
在许多类型的经皮针头插入手术中,组织变形和针头偏转会给准确的针头放置带来很大的困难。在本文中,我们提出了一种在二维超声(US)图像中自动跟踪针头的方法,该方法用于针头-组织相互作用模型中,以估计当前和未来的针尖偏转。这是使用半自动针转向系统进行演示的。US探头可以控制跟随针尖,也可以停在合适的位置,避免靶区组织变形。US图像用于充分参数化针组织模型。一旦针的偏转达到预定的阈值,机器人就会旋转针来纠正针尖的轨迹。实验结果表明,在有旋转和无旋转两种情况下,估算出的最终针尖挠度平均精度在0.7 ~ 1.0mm之间。所提出的方法为外科医生提供了改进的针尖偏转的US反馈,并最大限度地减少了US探头的运动,以减少目标区域的组织变形。
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引用次数: 23
期刊
J. Medical Robotics Res.
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