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Infant Feeding Practices In a Diverse Group of Women: The Healthy Start Study. 不同妇女群体的婴儿喂养实践:健康开端研究。
IF 1.5 Q2 PEDIATRICS Pub Date : 2019-01-20 eCollection Date: 2019-01-01 DOI: 10.1177/1179556518824362
Jill Landsbaugh Kaar, Katherine A Sauder, Allison Lb Shapiro, Anne P Starling, Brandy M Ringham, Susan L Johnson, Dana Dabelea

Background: To describe infant feeding practices among a diverse group of mother-offspring pairs and identify factors associated with adherence to the American Academy of Pediatrics (AAP) recommendations.

Methods: Data were analyzed from 835 mother-offspring dyads in The Healthy Start Study, an ongoing longitudinal prebirth cohort in Denver, Colorado. Maternal report of infant feeding practices was obtained at 4 to 6 months and 18 to 24 months postnatally. Practices were classified according to the following AAP recommendations: exclusive breastfeeding for first 6 months, continued breastfeeding through 12 months, and introduction of solid foods around 6 months of age. Participants who met all 3 recommendations were categorized as "adherent." All others were categorized as "not adherent."

Results: About 77% of dyads did not adhere fully to the AAP recommendations. Women who worked ⩾35 hours/week or had a higher prepregnancy body mass index were more likely to be nonadherent. Women who were older, college educated, or had offspring with greater weight for gestational age at birth were less likely to be nonadherent.

Conclusions: Most of the women in a large contemporary cohort are not adhering to AAP infant feeding recommendations. Our results highlight the specific subgroups of women who may need additional support to optimize infant feeding practices.

背景:描述一组不同的母子对的婴儿喂养实践,并确定与遵守美国儿科学会(AAP)建议相关的因素。方法:在科罗拉多州丹佛市的一项正在进行的纵向产前队列健康开始研究中,对835对母子进行数据分析。在出生后4至6个月和18至24个月获得婴儿喂养实践的母亲报告。根据美国儿科学会(AAP)的以下建议进行了分类:前6个月纯母乳喂养,持续母乳喂养至12个月,并在6个月左右引入固体食物。满足所有3条建议的参与者被归类为“坚持”。其他所有人都被归类为“不坚持”。结果:约77%的二人组没有完全遵守美国儿科学会的建议。每周工作35小时或怀孕前体重指数较高的女性更有可能不坚持。年龄较大、受过大学教育或子女出生时体重大于胎龄的妇女不坚持服药的可能性较小。结论:在一个大型当代队列中,大多数妇女没有遵守美国儿科学会婴儿喂养建议。我们的研究结果强调了可能需要额外支持以优化婴儿喂养实践的特定妇女亚组。
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引用次数: 4
Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study 新生儿低血糖脑损伤:一项基于医院的队列研究
IF 1.5 Q2 PEDIATRICS Pub Date : 2019-01-01 DOI: 10.1177/1179556519867953
Mei-hong Gu, F. Amanda, Tianming Yuan
Background: Neonatal hypoglycemia is more prevalent and can cause severe neurological sequelae. The objective of this study was to assess the patterns of neuroradiologic changes in neonatal hypoglycemia. Methods: A retrospective cohort study was conducted on 66 neonatal hypoglycemia patients, and the magnetic resonance imaging (MRI) and clinical records were reviewed. Results: Magnetic resonance imaging showed evidences of abnormality in 54.54% (36 of 66) of hypoglycemic infants. The most common abnormal findings were located on the parietal and occipital lobes of the brains. The number of days with hypoglycemia was significantly higher for abnormal MRI infants (P < .001), and prolonged/recurrent hypoglycemia was remarkably distinguished for abnormal MRI infants (P < .001). Patients with abnormal MRI findings did not have a lower blood glucose than infants without abnormal MRI findings (P > .05), but the lowest blood glucose was significantly lower for the patients with seizures (P < .01). Conclusions: The pattern of bilateral occipital cortical injury is the most common abnormality for neonatal hypoglycemia. The number of days with hypoglycemia, not the lower blood glucose, was significantly related to abnormal MRI infants.
背景:新生儿低血糖比较普遍,可引起严重的神经系统后遗症。本研究的目的是评估新生儿低血糖的神经影像学改变模式。方法:对66例新生儿低血糖患者进行回顾性队列研究,回顾磁共振成像(MRI)和临床资料。结果:66例低血糖婴儿中有36例(54.54%)磁共振成像显示异常。最常见的异常发现位于大脑的顶叶和枕叶。MRI异常患儿低血糖天数明显高于正常患儿(P < 0.05),癫痫发作患儿低血糖天数明显低于正常患儿(P < 0.01)。结论:双侧枕皮质损伤是新生儿低血糖最常见的异常。低血糖的天数,而不是低血糖,与异常的MRI婴儿有显著的关系。
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引用次数: 19
Human Papillomavirus–Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature 1例青少年人乳头瘤病毒相关口咽高级别神经内分泌癌:病例报告及文献复习
IF 1.5 Q2 PEDIATRICS Pub Date : 2019-01-01 DOI: 10.1177/1179556519870520
Sara Sinno, A. Assaad, Nina Salem Shabb
Oropharyngeal small cell carcinomas (OPSmCC) are rare with only few case reports and case series published in the literature. More recently, an association of these tumors with human papillomavirus (HPV) infection has been detected. However, unlike oropharyngeal squamous cell carcinomas which have a better outcome when associated with HPV, OPSmCC exhibit an aggressive behavior. In this article, we report a case of tonsillar carcinoma arising in a 14-year-old boy that was associated with HPV infection. The tumor exhibited morphologic features of small cell carcinoma with no overt squamous differentiation. Yet, by immunohistochemistry, it showed diffuse and strong co-expression of both squamous and neuroendocrine markers. In addition, we present the clinicopathologic features of all the cases of OPSmCC reported in the literature for which p16 and/or HPV testing have been done.
口咽小细胞癌(OPSmCC)是罕见的,只有少数病例报告和病例系列发表在文献中。最近,已发现这些肿瘤与人乳头瘤病毒(HPV)感染有关。然而,与与HPV相关的口咽鳞状细胞癌有更好的结果不同,OPSmCC表现出侵袭性行为。在这篇文章中,我们报告了一个14岁男孩扁桃体癌的病例,该病例与HPV感染有关。肿瘤表现为小细胞癌的形态学特征,无明显的鳞状分化。然而,免疫组织化学显示鳞状和神经内分泌标记物的弥漫性和强共表达。此外,我们提出了所有病例的临床病理特征的OPSmCC在文献中报告的p16和/或HPV检测已经完成。
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引用次数: 5
Perforated Small Intestine: A Case of a Delayed Presentation of an Intra-Abdominal Injury in a Pediatric Patient With a Seatbelt Sign 小肠穿孔:一例有安全带标志的儿童腹部损伤延迟表现
IF 1.5 Q2 PEDIATRICS Pub Date : 2019-01-01 DOI: 10.1177/1179556519876635
G. Taylor, Jonathan Zygowiec, Laurie C Wallace, Dawn C. Zelenka-Joshowitz, Angel F Chudler
With the use of seatbelts comes a unique injury profile that has been called “the seatbelt syndrome.” The classically described “seatbelt sign” has become a pattern of injury, describing potential underlying damage. As a clinician, clues to the underlying damage follow a thorough physical examination including the removal of all clothing to locate abrasions and bruises to the skin that potentially follow a seatbelt pattern. Delayed presentation of an intra-abdominal injury in the setting of a seatbelt sign has been well documented; however, the question is how long to observe these patients. We present the case of a 17-year-old woman involved in a motor vehicle collision who presented to the emergency department (ED) hemodynamically stable with a lower abdominal wall seatbelt sign. Her initial imaging revealed only an abdominal wall contusion. She was admitted for observation. Approximately 12 h later she started developing abdominal pain, and by 14 h abdominal distention, with repeat imaging showing free fluid and free air. She was taken to the operating room for an exploratory laparotomy and was ultimately discharged back home on day 7.
安全带的使用带来了一种独特的伤害特征,被称为“安全带综合症”。经典的“安全带标志”已经成为一种伤害模式,描述潜在的潜在伤害。作为一名临床医生,要通过彻底的身体检查找到潜在损伤的线索,包括脱掉所有的衣服,以确定皮肤上的擦伤和瘀伤,这些擦伤和瘀伤可能是安全带造成的。在系安全带标志的情况下,腹内损伤的延迟表现已经得到了充分的证明;然而,问题是要观察这些病人多长时间。我们提出的情况下,17岁的妇女参与机动车辆碰撞谁提出了急诊科(ED)血液动力学稳定与下腹壁安全带标志。她最初的影像显示只有腹壁挫伤。她被留院观察。大约12小时后,她开始出现腹痛,14小时腹胀,重复成像显示游离液体和游离空气。她被带到手术室进行剖腹探查,最终于第7天出院回家。
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引用次数: 1
Does Ramadan Fasting Affect Spirometric Data of Healthy Adolescents? 斋月禁食会影响健康青少年的肺活量测定数据吗?
IF 1.5 Q2 PEDIATRICS Pub Date : 2019-01-01 DOI: 10.1177/1179556519862280
Selma Ben Fraj, Amira Miladi, F. Guezguez, M. Ben rejeb, J. Bouguila, I. Gargouri, S. Rouatbi, I. Latiri, H. Ben Saad
Purpose: Several studies raised the effects of Ramadan fasting on healthy adults spirometric data, but none was performed in children. The aim of this study was to compare the spirometric data of a group of faster adolescents (n = 26) with an age-matched non-faster one (n = 10). Methods: This comparative quasi-experimental study, including 36 healthy males aged 12 to 15 years, was conducted during the summer 2015 (Ramadan: June 18 to July 16). Three sessions (Before-Ramadan [Before-R], Mid-Ramadan [Mid-R], After-Ramadan [After-R]) were selected for spirometry measurements. Spirometry was performed around 5.5 to 3.5 h before sunset and the spirometric data were expressed as percentages of local spirometric norms. Results: The two groups of fasters and non-fasters had similar ages and weights (13.35 ± 0.79 vs 12.96 ± 0.45 years, 46.8 ± 9.2 vs 41.7 ± 12.6 kg, respectively). There was no effect of Ramadan fasting on forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, peak expiratory flow, and maximal mid-expiratory flow. For example, during the Before-R, Mid-R, and After-R sessions, there was no significant difference between the fasters and non-fasters mean FVC (101 ± 11 vs 99 ± 14, 101 ± 12 vs 102 ± 14, 103 ± 11 vs 104 ± 13, respectively) or FEV1 (101 ± 13 vs 96 ± 16, 98 ± 11 vs 97 ± 16, 101 ± 10 vs 98 ± 16, respectively). Conclusions: Ramadan fasting had no interaction effect with the spirometric data of Tunisian healthy male adolescents.
目的:几项研究提出了斋月禁食对健康成人肺活量数据的影响,但没有在儿童中进行。本研究的目的是比较一组速度较快的青少年(n = 26)与年龄匹配的非速度较快的青少年(n = 10)的肺活量测定数据。方法:选取2015年夏季(斋月:6月18日至7月16日)健康男性36名,进行比较准实验研究。选取三个时段(斋月前[Before-R],斋月中期[Mid-R],斋月后[After-R])进行肺活量测定。在日落前5.5至3.5小时进行肺活量测定,肺活量数据以当地肺活量标准的百分比表示。结果:两组空腹组与非空腹组年龄、体重相近(分别为13.35±0.79 vs 12.96±0.45岁,46.8±9.2 vs 41.7±12.6 kg)。斋月禁食对用力肺活量(FVC)、1 s用力呼气量(FEV1)、FEV1/FVC、呼气峰流量和呼气中最大流量均无影响。例如,在r前、r中和r后阶段,快速者和非快速者的平均FVC(分别为101±11 vs 99±14、101±12 vs 102±14、103±11 vs 104±13)或FEV1(分别为101±13 vs 96±16、98±11 vs 97±16、101±10 vs 98±16)之间没有显著差异。结论:斋月禁食与突尼斯健康男性青少年肺活量测定数据无交互作用。
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引用次数: 5
Corrigendum. 勘误表。
IF 1.5 Q2 PEDIATRICS Pub Date : 2018-12-27 eCollection Date: 2018-01-01 DOI: 10.1177/1179556518800765

[This corrects the article DOI: 10.1177/1179556518784300.].

[这更正了文章DOI: 10.1177/1179556518784300.]。
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引用次数: 0
Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches. 支气管肺发育不良:当前药物疗法和新方法的最新进展。
IF 1.5 Q2 PEDIATRICS Pub Date : 2018-12-11 eCollection Date: 2018-01-01 DOI: 10.1177/1179556518817322
Zoe Michael, Fotios Spyropoulos, Sailaja Ghanta, Helen Christou

Bronchopulmonary dysplasia (BPD) remains the most prevalent long-term morbidity of surviving extremely preterm infants and is associated with significant health care utilization in infancy and beyond. Recent advances in neonatal care have resulted in improved survival of extremely low birth weight (ELBW) infants; however, the incidence of BPD has not been substantially impacted by novel interventions in this vulnerable population. The multifactorial cause of BPD requires a multi-pronged approach for prevention and treatment. New approaches in assisted ventilation, optimal nutrition, and pharmacologic interventions are currently being evaluated. The focus of this review is the current state of the evidence for pharmacotherapy in BPD. Promising future approaches in need of further study will also be reviewed.

支气管肺发育不良(BPD)仍然是极早产儿存活后最常见的长期发病率,并与婴儿期及以后大量使用医疗服务有关。新生儿护理领域的最新进展提高了极低出生体重儿(ELBW)的存活率;然而,在这一脆弱人群中,新型干预措施并未对 BPD 的发病率产生实质性影响。BPD 的病因是多方面的,因此需要多管齐下的预防和治疗方法。目前正在评估辅助通气、最佳营养和药物干预方面的新方法。本综述的重点是 BPD 药物治疗的证据现状。此外,还将对需要进一步研究的未来可行方法进行综述。
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引用次数: 0
Neonatal Cholestasis: A Pandora's Box. 新生儿胆汁淤积症:潘多拉的盒子。
IF 1.5 Q2 PEDIATRICS Pub Date : 2018-12-06 eCollection Date: 2018-01-01 DOI: 10.1177/1179556518805412
Aakash Pandita, Vishal Gupta, Girish Gupta

Neonatal cholestasis (NC) is a diagnostic dilemma frequently countered in a neonatal care unit. Early diagnosis is vital for achieving an optimal patient outcome as many causes of cholestasis such as biliary atresia are time-sensitive and amenable to treatment if analyzed and treated early. Nonetheless, it is not generally simple to analyze these cases right on time as some of them are regularly missed due to the presence of pigmented stools, lack of newborn metabolic screening, and named as instances of prolonged jaundice. In this manner, we prescribe to explore all reasons for prolonged jaundice stretching out past 14 days in neonates. Besides, we suggest that stool card ought to be a piece of release rundown for all newborn children being released from the nursery. This is of most extreme significance in the nation like India where guaranteeing customary follow-up is as yet a tough assignment. These stool cards will help in the early determination of patients with NC particularly biliary atresia and guarantee their auspicious cure. Another reason which needs exceptional say is parenteral nutrition-associated liver illness, as the proportion of preterm babies is getting greater and greater with better neonatal care. These extreme preterm infants are in the requirement for prolonged (>14 days) total parenteral nourishment because of which they are at high hazard for NC contrasted with their more developed peers. In this survey, we will give an understanding of clinical approach, differential diagnosis, and clinical review of NC.

新生儿胆汁淤积症(NC)是一个诊断困境,经常反击在新生儿护理单位。早期诊断对于获得最佳患者结果至关重要,因为胆汁淤积症的许多原因(如胆道闭锁)是时间敏感的,如果及早分析和治疗,可以进行治疗。然而,及时分析这些病例通常并不简单,因为其中一些病例由于存在色素粪便而经常被遗漏,缺乏新生儿代谢筛查,并被命名为长期黄疸的实例。以这种方式,我们规定探讨所有原因延长黄疸延伸过去14天的新生儿。此外,我们建议大便卡应该是所有新生儿从托儿所出院时的一张出院清单。这对于像印度这样的国家来说是最重要的,因为保证习惯性的后续行动是一项艰巨的任务。这些大便卡将有助于早期确定NC患者,特别是胆道闭锁,并保证他们的吉祥治愈。另一个需要特别说明的原因是肠外营养相关的肝脏疾病,随着新生儿护理的改善,早产儿的比例越来越大。这些极度早产儿需要长时间(>14天)的全肠外营养,因为与发育较好的同龄人相比,他们患NC的风险很高。在这个调查中,我们将给出临床方法的理解,鉴别诊断和临床回顾NC。
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引用次数: 10
Evaluating Accessible Sleep Health Information in Rural and Urban Contexts: Delivery Face-to-Face or Online? 评估农村和城市环境下可获得的睡眠健康信息:面对面还是在线传递?
IF 1.5 Q2 PEDIATRICS Pub Date : 2018-11-29 eCollection Date: 2018-01-01 DOI: 10.1177/1179556518815168
Joanne M Osborne, Sarah Blunden

Objective: New parents need education about infant sleep but is not universally available especially not in regional and rural areas. We delivered sleep education both face-to-face and online to test sleep knowledge acquisition for parents wherever they reside. Best practice delivery of accessible sleep health information for new families needs to be investigated more carefully in order for specialist services to be universally available.

Methods: Pre- and post-information session questionnaires (n = 32) assessed levels of knowledge acquisition and comparisons tested differences between face-to-face seminars compared with an online webinar.

Results: Sleep knowledge across participants was low (69% scoring < 50%). Sleep knowledge significantly increased for both the webinar delivery group (P = .002) and face-to-face delivery group (P = .001). No significant differences in knowledge acquisition were found between face-to-face vs online delivery (P = .170), suggesting both modes of delivery were sufficient to improve parental sleep knowledge.

Conclusions: Parental sleep knowledge, while low, increased with education. Online delivery was similar to face-to-face delivery suggesting ease of access for rural and remote communities needing specialist sleep information.

Implications for public health: Information delivered online is effective and offers a health delivery solution to regional and remote parents unable to access sleep services and rendering sleep service accessibility more equitable.

目的:新生儿父母需要进行婴儿睡眠教育,但这种教育并不普遍,特别是在农村地区。我们提供面对面和在线的睡眠教育,以测试父母的睡眠知识获取情况。需要更仔细地调查为新家庭提供可获得的睡眠健康信息的最佳做法,以便普遍提供专业服务。方法:信息会议前后问卷(n = 32)评估知识获取水平,比较测试面对面研讨会与在线网络研讨会之间的差异。结果:所有参与者的睡眠知识都很低(69%得分< 50%)。网络研讨会组(P = .002)和面对面讲座组(P = .001)的睡眠知识显著增加。面对面授课与在线授课在知识获取方面没有显著差异(P = 0.170),这表明两种授课方式都足以提高父母的睡眠知识。结论:父母睡眠知识水平虽低,但随着教育程度的提高而提高。在线交付与面对面交付相似,这表明需要专业睡眠信息的农村和偏远社区更容易获得。对公共卫生的影响:在线提供的信息是有效的,为无法获得睡眠服务的区域和偏远父母提供了保健服务解决方案,并使获得睡眠服务的机会更加公平。
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引用次数: 4
Factors Associated with Prescribing Broad-Spectrum Antibiotics for Children with Upper Respiratory Tract Infections in Ambulatory Care Settings. 在门诊护理环境中为上呼吸道感染儿童开具广谱抗生素处方的相关因素。
IF 1.5 Q2 PEDIATRICS Pub Date : 2018-07-02 DOI: 10.1177/1179556518784300
Mohammad S Alzahrani, Mary K Maneno, Monika N Daftary, La'Marcus Wingate, Earl B Ettienne

Objectives: Broad-spectrum antibiotics are frequently prescribed for children with upper respiratory tract infections (URI). Excessive use of broad-spectrum antibiotics leads to the emergence of resistant bacteria. This study aimed to identify factors associated with prescribing broad-spectrum antibiotics among children younger than 18 years presenting with URI in outpatient settings.

Methods: We conducted a cross-sectional analysis of the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey-Outpatient Departments (NHAMCS-OPD) between 2006 and 2010. Descriptive statistics of visits from children with URI were estimated. Simple and multiple logistic regression analyses were used to identify socio-demographic and clinical characteristics associated with broad-spectrum antibiotic prescribing. We also completed a stratified analysis by age (⩽2 vs >2).

Results: A total of 4013 outpatient visits for children with URI from both NAMCS and NHAMCS-0PD data were examined. Broad-spectrum antibiotics were prescribed in 39% of the visits, accounting for an estimated 6.8 million visits annually. Multivariable analysis showed that visits in the South region (odds ratio [OR] = 2.38; 95% confidence interval [CI]: 1.38-4.10) compared with the West region and visits with diagnoses of acute sinusitis (OR = 2.77; 95% CI: 1.65-4.63) and acute otitis media (OR = 1.90; 95% CI: 1.32-2.74) compared with those with acute pharyngitis were associated with greater odds of broad-spectrum antibiotic prescribing.

Conclusions: The prescribing of broad-spectrum antibiotics is common for children with URI in ambulatory care settings. Diagnosis and management of URI remain a critical area for awareness campaigns promoting judicious use of antibiotics.

目的:广谱抗生素经常用于儿童上呼吸道感染(URI)。过度使用广谱抗生素会导致耐药细菌的出现。本研究旨在确定18岁以下儿童使用广谱抗生素的相关因素 在门诊环境中使用URI的年数。方法:我们对2006年至2010年间的全国门诊医疗调查(NAMCS)和全国医院门诊医疗调查门诊部(NHAMCS-OPD)进行了横断面分析。估计了URI儿童就诊的描述性统计数据。使用简单和多元逻辑回归分析来确定与广谱抗生素处方相关的社会人口统计学和临床特征。我们还完成了按年龄进行的分层分析(⩽2 vs>2)。结果:根据NAMCS和NHAMCS-0PD数据,共检查了4013例URI儿童门诊就诊。39%的就诊中使用了广谱抗生素,估计占6.8 每年访问量达百万人次。多变量分析显示,在南部地区就诊(比值比[OR] = 2.38;95%置信区间[CI]:1.38-4.10)与西部地区相比,以及诊断为急性鼻窦炎(OR = 2.77;95%可信区间:1.65-4.63)和急性中耳炎(OR = 1.90;95%可信区间:1.32-2.74)与急性咽炎患者相比,与更大的广谱抗生素处方几率相关。结论:在门诊护理环境中,对URI儿童开具广谱抗生素处方很常见。URI的诊断和管理仍然是促进明智使用抗生素的宣传活动的关键领域。
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引用次数: 17
期刊
Clinical Medicine Insights-Pediatrics
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