Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第4页

Influence of parallel holes in bone regenerative material for vertical bone augmentation 骨再生材料中平行孔对垂直骨增强的影响

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-08-07 DOI: 10.1016/j.ajoms.2025.07.016

Toshiki Yanagisawa , Keiko Matsui , Yushi Ezoe , Atsumu Kouketsu , Kei-ichiro Miura , Tomohiro Yamada , Shinji Kamakura

Objective

Recently, liquid nitrogen-treated octacalcium phosphate and collagen composite (OCPcol) has demonstrated reproducible bone augmentation. Previous studies suggested that orderly arranged unidirectional macropores could enhance bone formation within the implant. This study aimed to investigate whether different types of unidirectional macropores in liquid nitrogen-treated OCPcol influence bone augmentation.

Methods

Liquid nitrogen-treated OCPcol disks were prepared with parallel holes in the axial direction and divided into four groups: Open (through holes), Top (blind holes from top), Bottom (blind holes from bottom), and Untreated (no holes). These disks were implanted in rodent calvarial subperiosteal pockets. Bone formation and implant structure were evaluated after 12 weeks using radiomorphometric and histological analyses.

Results

Radiomorphometric analysis revealed that the Open group exhibited a greater degree of deformation compared to the other groups, but all groups maintained their height and shape overall. Histomorphometric analysis showed that appositional bone formation was primarily enhanced from the surface of the existing bone towards the inside of the implants. Among the groups, the Open group demonstrated the lowest appositional bone formation.

Conclusions

The addition of unidirectional macropores to OCPcol had a limited effect on appositional bone formation compared with the impact of liquid nitrogen treatment. These findings suggest that while macropores may play a role in bone regeneration, their effect is secondary to the structural and biological advantages conferred by liquid nitrogen-treated OCPcol.

目的近年来，液氮处理的磷酸八钙和胶原复合材料（OCPcol）已被证明是可再生的骨增强材料。先前的研究表明，有序排列的单向大孔可以促进种植体内骨的形成。本研究旨在探讨液氮处理OCPcol中不同类型的单向大孔是否影响骨增强。方法将经液氮处理的OCPcol盘沿轴向平行开孔，分为开孔组（通孔组）、上孔组（上盲孔组）、下孔组（下盲孔组）和未孔组（无孔组）。这些圆盘被植入啮齿动物的颅骨骨膜下口袋。12周后用放射形态学和组织学分析评估骨形成和种植体结构。结果放射形态分析结果显示，Open组与其他组相比，表现出更大程度的变形，但所有组的身高和形状总体保持不变。组织形态学分析表明，相对骨形成主要是从现有骨的表面向种植体内部增强的。在各组中，开放组显示出最低的对位骨形成。结论与液氮处理相比，单向大孔对骨形成的影响有限。这些发现表明，虽然大孔可能在骨再生中发挥作用，但其作用次于液氮处理的OCPcol所带来的结构和生物学优势。

{"title":"Influence of parallel holes in bone regenerative material for vertical bone augmentation","authors":"Toshiki Yanagisawa , Keiko Matsui , Yushi Ezoe , Atsumu Kouketsu , Kei-ichiro Miura , Tomohiro Yamada , Shinji Kamakura","doi":"10.1016/j.ajoms.2025.07.016","DOIUrl":"10.1016/j.ajoms.2025.07.016","url":null,"abstract":"<div><h3>Objective</h3><div>Recently, liquid nitrogen-treated octacalcium phosphate and collagen composite (OCPcol) has demonstrated reproducible bone augmentation. Previous studies suggested that orderly arranged unidirectional macropores could enhance bone formation within the implant. This study aimed to investigate whether different types of unidirectional macropores in liquid nitrogen-treated OCPcol influence bone augmentation.</div></div><div><h3>Methods</h3><div>Liquid nitrogen-treated OCPcol disks were prepared with parallel holes in the axial direction and divided into four groups: Open (through holes), Top (blind holes from top), Bottom (blind holes from bottom), and Untreated (no holes). These disks were implanted in rodent calvarial subperiosteal pockets. Bone formation and implant structure were evaluated after 12 weeks using radiomorphometric and histological analyses.</div></div><div><h3>Results</h3><div>Radiomorphometric analysis revealed that the Open group exhibited a greater degree of deformation compared to the other groups, but all groups maintained their height and shape overall. Histomorphometric analysis showed that appositional bone formation was primarily enhanced from the surface of the existing bone towards the inside of the implants. Among the groups, the Open group demonstrated the lowest appositional bone formation.</div></div><div><h3>Conclusions</h3><div>The addition of unidirectional macropores to OCPcol had a limited effect on appositional bone formation compared with the impact of liquid nitrogen treatment. These findings suggest that while macropores may play a role in bone regeneration, their effect is secondary to the structural and biological advantages conferred by liquid nitrogen-treated OCPcol.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 52-58"},"PeriodicalIF":0.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mandibular fractures associated with third molar extraction: A systematic review and meta-analysis 下颌骨折与第三磨牙拔牙相关：系统回顾和荟萃分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-08-05 DOI: 10.1016/j.ajoms.2025.07.015

Pablo Andrés Crespo-Reinoso, Karen Andrea Ochoa Ayora

Objective

This study aims to analyze the association between third molar surgery and mandibular fractures, with the goal of providing information to help surgeons prevent such fractures and guide appropriate treatment when they occur.

Methods

A systematic review was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive search strategy was applied in PubMed and ScienceDirect using relevant MeSH terms. Inclusion criteria were based on the PICO framework. Data extraction and risk of bias assessments were performed for all included studies.

Results

The combined proportion of mandibular fractures was 4.2 %, with a confidence interval ranging from 2.7 % to 5.7 %. An extremely high heterogeneity was observed (I² = 99.1 %, Q = 766.05, p < 0.001), indicating true variation among the studies. Meta-regression showed no significant relationship between the fracture proportion and variables such as mean age or percentage of male participants. Subgroup analysis revealed that studies reporting postoperative fractures had higher combined proportions, suggesting a potentially important clinical pattern worthy of further investigation.

Conclusions

The present study analyzed the association between third molar surgery and mandibular fractures, aiming to provide useful information for their prevention. It was observed that these fractures occur more frequently in the postoperative period, highlighting the importance of implementing preventive measures before, during and the procedure.

目的分析第三磨牙手术与下颌骨骨折之间的关系，为外科医生预防此类骨折和指导适当的治疗提供信息。方法按照PRISMA 2020指南进行系统评价。在PubMed和ScienceDirect中使用相关MeSH术语进行综合搜索策略。纳入标准基于PICO框架。对所有纳入的研究进行数据提取和偏倚风险评估。结果下颌骨骨折合并比例为4.2 %，可信区间为2.7 % ~ 5.7 %。观察到极高的异质性（I²= 99.1 %,Q = 766.05, p <； 0.001），表明研究之间存在真正的差异。meta回归显示骨折比例与平均年龄或男性参与者百分比等变量之间无显著关系。亚组分析显示，报道术后骨折的研究有更高的合并比例，提示一个潜在的重要临床模式值得进一步研究。结论本研究分析了第三磨牙手术与下颌骨折的关系，旨在为其预防提供有用的信息。观察到这些骨折在术后发生的频率更高，强调了术前、术中和术中实施预防措施的重要性。

{"title":"Mandibular fractures associated with third molar extraction: A systematic review and meta-analysis","authors":"Pablo Andrés Crespo-Reinoso, Karen Andrea Ochoa Ayora","doi":"10.1016/j.ajoms.2025.07.015","DOIUrl":"10.1016/j.ajoms.2025.07.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyze the association between third molar surgery and mandibular fractures, with the goal of providing information to help surgeons prevent such fractures and guide appropriate treatment when they occur.</div></div><div><h3>Methods</h3><div>A systematic review was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive search strategy was applied in PubMed and ScienceDirect using relevant MeSH terms. Inclusion criteria were based on the PICO framework. Data extraction and risk of bias assessments were performed for all included studies.</div></div><div><h3>Results</h3><div>The combined proportion of mandibular fractures was 4.2 %, with a confidence interval ranging from 2.7 % to 5.7 %. An extremely high heterogeneity was observed (I² = 99.1 %, Q = 766.05, p < 0.001), indicating true variation among the studies. Meta-regression showed no significant relationship between the fracture proportion and variables such as mean age or percentage of male participants. Subgroup analysis revealed that studies reporting postoperative fractures had higher combined proportions, suggesting a potentially important clinical pattern worthy of further investigation.</div></div><div><h3>Conclusions</h3><div>The present study analyzed the association between third molar surgery and mandibular fractures, aiming to provide useful information for their prevention. It was observed that these fractures occur more frequently in the postoperative period, highlighting the importance of implementing preventive measures before, during and the procedure.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 11-15"},"PeriodicalIF":0.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenomatoid hyperplasia of the minor salivary glands: Dr. Hamilton B.G. Robinson’s forgotten first report 小唾液腺腺瘤样增生：Hamilton B.G. Robinson医生被遗忘的第一份报告

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-30 DOI: 10.1016/j.ajoms.2025.07.014

Fumio Ide , Michiko Nishimura , Shinnichi Sakamoto, Kentaro Kikuchi

引用次数: 0

Incidence and risk factors of medication-related osteonecrosis of the jaw in patients with advanced cancer treated with high-dose antiresorptive drugs: A retrospective cohort study 大剂量抗吸收药物治疗晚期癌症患者颌骨药物相关性骨坏死的发生率及危险因素：一项回顾性队列研究

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-27 DOI: 10.1016/j.ajoms.2025.07.012

Takashi Baba , Yu Yamaguma , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita

Objectives

Anti-resorptive agents (ARA), such as bisphosphonates and denosumab, are first-line treatments for bone metastases from solid tumors and multiple myeloma. Although these agents effectively inhibit bone resorption, relieve pain associated with bone metastases, and inhibit the growth of bone metastases in malignant diseases, the risk of medication-related osteonecrosis of the jaw (MRONJ) remains a significant concern. In this study, we retrospectively examined patients who received high-dose ARA at our hospital after their initial visit to our department, focusing on their oral condition at the time of the initial visit and at the start of high-dose ARA treatment.

Methods

Between 2013 and 2023, 91 patients who received high-dose ARA at our hospital after their initial visit to our department with at least 3 months of follow-up were retrospectively investigated from their medical records. We examined various factors that may increase the risk of MRONJ, but we focused on dental conditions at high-dose ARA administration.

Results

Univariate Cox regression analysis showed that sex, steroid use, tooth indicated for extraction at initial visit and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. Furthermore, multivariate Cox regression analysis showed that steroid use and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. (p < 0.05).

Conclusion

A pre-treatment dental examination and timely extraction of the indicated tooth prior to high-dose ARA administration may reduce the risk of MRONJ. These findings highlight the importance of early dental intervention in patients receiving high-dose ARA treatment.

目的：抗骨吸收药物（ARA），如双膦酸盐和地诺单抗，是治疗实体瘤和多发性骨髓瘤骨转移的一线药物。尽管这些药物有效地抑制骨吸收，缓解骨转移相关的疼痛，并抑制恶性疾病中骨转移的生长，但药物相关性颌骨骨坏死（MRONJ）的风险仍然是一个值得关注的问题。在本研究中，我们回顾性调查了首次到我科就诊后在我院接受高剂量ARA治疗的患者，重点关注他们首次就诊时和高剂量ARA治疗开始时的口腔状况。方法回顾性分析2013 - 2023年间91例首次来我科接受大剂量ARA治疗并随访至少3个月的患者病历资料。我们检查了可能增加MRONJ风险的各种因素，但我们关注的是高剂量ARA给药时的牙齿状况。结果单因素Cox回归分析显示，性别、类固醇使用情况、初诊时需要拔除的牙齿和大剂量ARA给药时需要拔除的牙齿与MRONJ的发生显著相关。此外，多变量Cox回归分析显示，在大剂量ARA给药下，类固醇的使用和拔牙指示与MRONJ的发展显著相关。(p & lt; 0.05)。结论大剂量ARA给药前进行治疗前口腔检查，及时拔除指牙，可降低MRONJ的发生风险。这些发现强调了接受高剂量ARA治疗的患者早期牙科干预的重要性。

{"title":"Incidence and risk factors of medication-related osteonecrosis of the jaw in patients with advanced cancer treated with high-dose antiresorptive drugs: A retrospective cohort study","authors":"Takashi Baba , Yu Yamaguma , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita","doi":"10.1016/j.ajoms.2025.07.012","DOIUrl":"10.1016/j.ajoms.2025.07.012","url":null,"abstract":"<div><h3>Objectives</h3><div>Anti-resorptive agents (ARA), such as bisphosphonates and denosumab, are first-line treatments for bone metastases from solid tumors and multiple myeloma. Although these agents effectively inhibit bone resorption, relieve pain associated with bone metastases, and inhibit the growth of bone metastases in malignant diseases, the risk of medication-related osteonecrosis of the jaw (MRONJ) remains a significant concern. In this study, we retrospectively examined patients who received high-dose ARA at our hospital after their initial visit to our department, focusing on their oral condition at the time of the initial visit and at the start of high-dose ARA treatment.</div></div><div><h3>Methods</h3><div>Between 2013 and 2023, 91 patients who received high-dose ARA at our hospital after their initial visit to our department with at least 3 months of follow-up were retrospectively investigated from their medical records. We examined various factors that may increase the risk of MRONJ, but we focused on dental conditions at high-dose ARA administration.</div></div><div><h3>Results</h3><div>Univariate Cox regression analysis showed that sex, steroid use, tooth indicated for extraction at initial visit and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. Furthermore, multivariate Cox regression analysis showed that steroid use and tooth indicated for extraction at high-dose ARA administration were significantly associated with MRONJ development. (<em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>A pre-treatment dental examination and timely extraction of the indicated tooth prior to high-dose ARA administration may reduce the risk of MRONJ. These findings highlight the importance of early dental intervention in patients receiving high-dose ARA treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 140-145"},"PeriodicalIF":0.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental papillary thyroid carcinoma metastases in neck dissection specimens of oral cancer: Three cases 口腔癌颈部解剖标本中偶发甲状腺乳头状癌转移3例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-22 DOI: 10.1016/j.ajoms.2025.07.011

Keisuke Ito, Yasunori Konno, Misaki Arima, Yuki Oikawa, Shoken Suzuki, Kenichiro Suzuki, Mineyo Fukuchi, Hidemitsu Igarashi, Hiroshi Takano, Masayuki Fukuda

Incidental papillary thyroid carcinoma (PTC) metastases discovered during neck dissection for oral cancer present unique diagnostic and therapeutic challenges. We report three cases of incidental PTC metastases found during treatment of oral squamous cell carcinoma (SCC). Three patients underwent modified radical neck dissection as part of their oral SCC treatment and histopathological examination revealed unexpected PTC metastases in the cervical lymph nodes. The first case (tongue SCC, cT2N2bM0) had two PTC metastases in the right middle and lower internal jugular nodes. The second case (tongue SCC, cT3N2bM0) had eight PTC metastases across multiple neck levels, with the subsequent discovery of a 2 mm primary thyroid tumor. The third case (maxillary SCC, cT4aN2bM0) had one PTC metastasis in the left lower internal jugular node. None showed thyroid abnormalities in preoperative imaging. In the second case, total thyroidectomy was performed postoperatively, and the diagnosis of thyroid cancer was confirmed micropapillary thyroid carcinoma (pT1aN2bM0). These cases highlight the importance of thorough pathological examination of neck dissection specimens. The management of incidental PTC requires careful consideration of multiple factors, including primary cancer status, patient age, and overall health condition. The typically favorable prognosis of PTC often allows prioritization of more aggressive concurrent malignancies. While standard imaging may miss approximately 2 % of thyroid cancers, particularly smaller tumors, our experience indicates that regular ultrasound monitoring is effective for disease surveillance. These findings suggest the need for established protocols in managing such incidental discoveries, balancing treatment necessity against patient burden.

偶然甲状腺乳头状癌（PTC）转移发现颈部清扫口腔癌提出了独特的诊断和治疗挑战。我们报告三例偶然的PTC转移发现在治疗口腔鳞状细胞癌（SCC）。3例患者接受改良根治性颈部清扫术作为口腔SCC治疗的一部分，组织病理学检查显示意外的PTC在颈部淋巴结转移。第一例（舌SCC， cT2N2bM0）在右侧颈内中下淋巴结有两个PTC转移。第二个病例（舌SCC， cT3N2bM0）有8个PTC转移到多个颈部水平，随后发现一个2 mm的原发性甲状腺肿瘤。第三例（上颌鳞状细胞癌，cT4aN2bM0）在左下颈内结有1例PTC转移。术前影像学未见甲状腺异常。第二例患者术后行甲状腺全切除术，确诊甲状腺癌为甲状腺微乳头状癌（pT1aN2bM0）。这些病例强调了对颈部解剖标本进行彻底病理检查的重要性。偶发性PTC的管理需要仔细考虑多种因素，包括原发癌症状态、患者年龄和整体健康状况。PTC典型的良好预后通常允许优先考虑更具侵袭性的并发恶性肿瘤。虽然标准成像可能会遗漏约2% %的甲状腺癌，特别是较小的肿瘤，但我们的经验表明，定期超声监测对疾病监测是有效的。这些发现表明，需要建立管理此类偶然发现的方案，平衡治疗必要性和患者负担。

{"title":"Incidental papillary thyroid carcinoma metastases in neck dissection specimens of oral cancer: Three cases","authors":"Keisuke Ito, Yasunori Konno, Misaki Arima, Yuki Oikawa, Shoken Suzuki, Kenichiro Suzuki, Mineyo Fukuchi, Hidemitsu Igarashi, Hiroshi Takano, Masayuki Fukuda","doi":"10.1016/j.ajoms.2025.07.011","DOIUrl":"10.1016/j.ajoms.2025.07.011","url":null,"abstract":"<div><div>Incidental papillary thyroid carcinoma (PTC) metastases discovered during neck dissection for oral cancer present unique diagnostic and therapeutic challenges. We report three cases of incidental PTC metastases found during treatment of oral squamous cell carcinoma (SCC). Three patients underwent modified radical neck dissection as part of their oral SCC treatment and histopathological examination revealed unexpected PTC metastases in the cervical lymph nodes. The first case (tongue SCC, cT2N2bM0) had two PTC metastases in the right middle and lower internal jugular nodes. The second case (tongue SCC, cT3N2bM0) had eight PTC metastases across multiple neck levels, with the subsequent discovery of a 2 mm primary thyroid tumor. The third case (maxillary SCC, cT4aN2bM0) had one PTC metastasis in the left lower internal jugular node. None showed thyroid abnormalities in preoperative imaging. In the second case, total thyroidectomy was performed postoperatively, and the diagnosis of thyroid cancer was confirmed micropapillary thyroid carcinoma (pT1aN2bM0). These cases highlight the importance of thorough pathological examination of neck dissection specimens. The management of incidental PTC requires careful consideration of multiple factors, including primary cancer status, patient age, and overall health condition. The typically favorable prognosis of PTC often allows prioritization of more aggressive concurrent malignancies. While standard imaging may miss approximately 2 % of thyroid cancers, particularly smaller tumors, our experience indicates that regular ultrasound monitoring is effective for disease surveillance. These findings suggest the need for established protocols in managing such incidental discoveries, balancing treatment necessity against patient burden.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 88-93"},"PeriodicalIF":0.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smokeless tobacco mediated alterations on the prevalence of oral pathogens and interactions of tobacco-specific nitrosamines (TSNAs) with host proteins 无烟烟草介导的口腔病原体患病率的改变以及烟草特异性亚硝胺（TSNAs）与宿主蛋白的相互作用

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-16 DOI: 10.1016/j.ajoms.2025.07.010

Mohammad Sajid , Lata Joshi , Shailendra Shakya , Mausumi Bharadwaj

Objective

Smokeless tobacco (SLT) product consumption is a major public health concern, especially in Southeast Asian countries, and a risk factor for oral cancer. Interference of host-oral microbiota homeostasis can promote oral cancer progression. SLT use can induce oral microbial population alterations that can contribute to oral pathologies including oral cancer.

Methods

In this study, we have determined the clinically relevant bacterial phyla and pathogens in the SLT users’ oral cavity (n = 95) and non-users (n = 85). Further, we checked the interaction of tobacco-associated toxic chemicals with the host proteins using the STITCH tool (http://stitch.embl.de/).

Results

We observed that the pathogens like Candida sp., Chlamydia trachomatis, and Human papillomavirus were significantly high in SLT users, whereas the occurrence of Trichomonas vaginalis was high in non-users. Further, the abundance of bacterial phyla including Actinobacteria, Bacteroidetes, and Fusobacteria, was significantly elevated in SLT users whereas phyla Proteobacteria prevalence was diminished in SLT users compared to non-users. Additionally, we observed that several host proteins including Cytochrome-P450, UDP-glucuronosyltransferase, and nicotinic acetylcholine receptors were showing strong interactions with toxic compounds present in SLT like nicotine, NNK, NNAL, NNN, and NAB.

Conclusions

These results indicate that SLT consumption can alter the oral bacterial and viral population and influence several proteins in SLT users. Therefore, enrichment of pathogenic bacteria along with depletion of beneficial bacteria can contribute to oral pathologies. This study will assist clinically in connecting the missing dots of pathogen population enrichment in the oral cavity of SLT users due to chewing of SLT products.

目的无烟烟草（SLT）产品消费是一个主要的公共卫生问题，特别是在东南亚国家，也是口腔癌的一个危险因素。干扰宿主-口腔微生物群动态平衡可促进口腔癌的进展。使用SLT可引起口腔微生物群的改变，从而导致包括口腔癌在内的口腔病理。方法本研究对SLT服用者（n = 95）和非服用者（n = 85）口腔中与临床相关的细菌门类和病原体进行了检测。此外，我们使用STITCH工具（http://stitch.embl.de/）.ResultsWe)检查了烟草相关有毒化学物质与宿主蛋白的相互作用，观察到假丝酵母菌、沙眼衣原体和人乳头瘤病毒等病原体在SLT使用者中显著高，而阴道毛滴虫在非SLT使用者中发生率高。此外，包括放线菌门、拟杆菌门和梭杆菌门在内的细菌门的丰度在SLT使用者中显著升高，而变形杆菌门的流行率在SLT使用者中与非SLT使用者相比有所降低。此外，我们观察到几种宿主蛋白，包括细胞色素- p450、udp -葡萄糖醛基转移酶和烟碱乙酰胆碱受体，与SLT中存在的有毒化合物如尼古丁、NNK、NNAL、NNN和NAB表现出强烈的相互作用。结论SLT的摄入可以改变口腔细菌和病毒的数量，并影响SLT使用者的几种蛋白质。因此，致病菌的富集和有益菌的消耗可能导致口腔病变。本研究将有助于临床补上咀嚼SLT产品导致SLT使用者口腔内病原菌种群富集的缺失点。

{"title":"Smokeless tobacco mediated alterations on the prevalence of oral pathogens and interactions of tobacco-specific nitrosamines (TSNAs) with host proteins","authors":"Mohammad Sajid , Lata Joshi , Shailendra Shakya , Mausumi Bharadwaj","doi":"10.1016/j.ajoms.2025.07.010","DOIUrl":"10.1016/j.ajoms.2025.07.010","url":null,"abstract":"<div><h3>Objective</h3><div>Smokeless tobacco (SLT) product consumption is a major public health concern, especially in Southeast Asian countries, and a risk factor for oral cancer. Interference of host-oral microbiota homeostasis can promote oral cancer progression. SLT use can induce oral microbial population alterations that can contribute to oral pathologies including oral cancer.</div></div><div><h3>Methods</h3><div>In this study, we have determined the clinically relevant bacterial phyla and pathogens in the SLT users’ oral cavity (n = 95) and non-users (n = 85). Further, we checked the interaction of tobacco-associated toxic chemicals with the host proteins using the STITCH tool (<span><span>http://stitch.embl.de/</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>We observed that the pathogens like <em>Candida</em> sp., <em>Chlamydia trachomatis</em>, and Human papillomavirus were significantly high in SLT users, whereas the occurrence of <em>Trichomonas vaginalis</em> was high in non-users. Further, the abundance of bacterial phyla including <em>Actinobacteria</em>, <em>Bacteroidetes</em>, and <em>Fusobacteria,</em> was significantly elevated in SLT users whereas phyla <em>Proteobacteria</em> prevalence was diminished in SLT users compared to non-users. Additionally, we observed that several host proteins including Cytochrome-P450, UDP-glucuronosyltransferase, and nicotinic acetylcholine receptors were showing strong interactions with toxic compounds present in SLT like nicotine, NNK, NNAL, NNN, and NAB.</div></div><div><h3>Conclusions</h3><div>These results indicate that SLT consumption can alter the oral bacterial and viral population and influence several proteins in SLT users. Therefore, enrichment of pathogenic bacteria along with depletion of beneficial bacteria can contribute to oral pathologies. This study will assist clinically in connecting the missing dots of pathogen population enrichment in the oral cavity of SLT users due to chewing of SLT products.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 133-139"},"PeriodicalIF":0.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic resistance in odontogenic infections – Systematic review 牙源性感染的抗生素耐药性-系统综述

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-15 DOI: 10.1016/j.ajoms.2025.07.008

Hallab Lamiae , Taleb Bouchra

Objectives/hypothesis

We review the resistance of antibiotics in odontogenic infection based on the various studies conducted for this purpose.

Methods

An electronic search was conducted since March 2022 until November 2022 on MEDLINE database, ELSEVIER- ScienceDirect, Ebsco, Scopus and Google Scholar to collect sufficient articles relevant to our subject. Data were extracted and analyzed from selected studies including study type, sample size and characteristics of microbiology and resistance found in these patients.

Results

A total of 120 publications were found. After screening titles, abstracts, and duplicates studies were retained 97 for a full text reading. Then, twenty seven studies were retained for our systematic review based on the inclusion and exclusion criteria which will be described later.

Conclusion

Odontogenic infections (OIs) are common in the oral and maxillofacial regions and can affect both genders at any age. The microbiology involved is very diversified, and frequently mixed. Management includes prescription of antimicrobial medication, surgical and etiological treatment. Then, the over-use or inappropriate selection of systemic antibiotic therapy is identified as a significant factor in the development of antibiotic-resistant bacterial strains.

目的/假设我们在为此目的进行的各种研究的基础上回顾抗生素在牙源性感染中的耐药性。方法自2022年3月至2022年11月在MEDLINE数据库、ELSEVIER- ScienceDirect、Ebsco、Scopus和b谷歌Scholar上进行电子检索，收集与本课题相关的充足文章。从选定的研究中提取数据并进行分析，包括研究类型、样本量以及这些患者中发现的微生物学特征和耐药性。结果共发现文献120篇。在筛选了题目、摘要和重复研究后，保留了97项研究以供全文阅读。然后，根据纳入和排除标准，保留27项研究用于我们的系统评价，这些标准将在后面描述。结论牙源性感染常见于口腔颌面部，男女老少均可发生。所涉及的微生物非常多样化，而且经常是混合的。管理包括抗菌药物处方、手术和病因治疗。然后，系统抗生素治疗的过度使用或不适当选择被确定为抗生素耐药菌株发展的重要因素。

{"title":"Antibiotic resistance in odontogenic infections – Systematic review","authors":"Hallab Lamiae , Taleb Bouchra","doi":"10.1016/j.ajoms.2025.07.008","DOIUrl":"10.1016/j.ajoms.2025.07.008","url":null,"abstract":"<div><h3>Objectives/hypothesis</h3><div>We review the resistance of antibiotics in odontogenic infection based on the various studies conducted for this purpose.</div></div><div><h3>Methods</h3><div>An electronic search was conducted since March 2022 until November 2022 on MEDLINE database, ELSEVIER- ScienceDirect, Ebsco, Scopus and Google Scholar to collect sufficient articles relevant to our subject. Data were extracted and analyzed from selected studies including study type, sample size and characteristics of microbiology and resistance found in these patients.</div></div><div><h3>Results</h3><div>A total of 120 publications were found. After screening titles, abstracts, and duplicates studies were retained 97 for a full text reading. Then, twenty seven studies were retained for our systematic review based on the inclusion and exclusion criteria which will be described later.</div></div><div><h3>Conclusion</h3><div>Odontogenic infections (OIs) are common in the oral and maxillofacial regions and can affect both genders at any age. The microbiology involved is very diversified, and frequently mixed. Management includes prescription of antimicrobial medication, surgical and etiological treatment. Then, the over-use or inappropriate selection of systemic antibiotic therapy is identified as a significant factor in the development of antibiotic-resistant bacterial strains.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 118-132"},"PeriodicalIF":0.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of localized tenosynovial giant cell tumor in the temporomandibular joint recurred 9 years after surgery 一例颞下颌关节局部腱鞘巨细胞瘤术后9年复发

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-13 DOI: 10.1016/j.ajoms.2025.07.001

Kaori Matsumura , Kazunari Oobu , Taichi Hattori , Keisuke Mori , Noritaka Komune , Shintaro Kawano , Eiro Kubota

Tenosynovial giant cell tumor (TGCT), as proposed by Jaffe et al. in 1941, is initially reported as a disease involving inflammatory proliferative changes in the synovial membrane. However, its neoplastic nature has been recently demonstrated. The lesion mostly affects the joint of long bones, but it rarely occurs in the temporomandibular joint. Here we report a case of TGCT that occurred in the temporomandibular joint and recurred 9 years postoperatively.

腱鞘巨细胞瘤（teno滑膜巨细胞瘤，TGCT）由Jaffe等人于1941年提出，最初被报道为滑膜炎症性增生性改变的疾病。然而，其肿瘤性质最近已被证实。病变主要影响长骨关节，但很少发生在颞下颌关节。我们在此报告一例发生于颞下颌关节的TGCT，术后9年复发。

引用次数: 0

A case of palatal canalicular adenoma 腭小管腺瘤1例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-09 DOI: 10.1016/j.ajoms.2025.07.009

Hitomi Kajikawa , Yoshihiro Morita , Kaori Oya , Ryotaro Kakimoto , Sho Katsura , Emiko Ogasa , Yukiko Kitahira , Yuka Matsumiya-Matsumoto , Akinori Takeshita , Narikazu Uzawa

Canalicular adenoma (CA) is a rare, benign salivary gland tumor accounting for less than 1 % of all salivary gland tumors and 4–6 % of minor salivary gland tumors. We report a case of CA in the palate that was initially suspected to be malignant owing to the appearance of the lesion surface following a laser incision performed at another hospital. A 58-year-old woman presented with swelling of the palatal mucosa in the right maxillary molar area. Computed tomography and magnetic resonance imaging revealed a soft tissue mass; however, because the patient had a history of asthma and non-contrast imaging was selected for these imaging tests, the imaging findings did not differentiate between benign and malignant tumors. A diagnosis of CA was made based on hematoxylin and eosin staining and immunohistochemistry of the biopsy sample. The lesion was surgically removed from the palatal mucosa under general anesthesia. At the 12-month postoperative follow-up, the patient exhibited good healing with no evidence of recurrence.

小管腺瘤（CA）是一种罕见的良性唾液腺肿瘤，占所有唾液腺肿瘤的不到1 %，占轻微唾液腺肿瘤的4 - %。我们报告一例CA在上颚，最初怀疑是恶性的，因为在另一家医院激光切口后病变表面的外观。一位58岁的女性表现为右侧上颌磨牙区腭黏膜肿胀。计算机断层扫描和磁共振成像显示软组织肿块；然而，由于患者有哮喘病史，这些影像学检查选择非对比成像，因此影像学结果无法区分良性和恶性肿瘤。根据活检样本的苏木精和伊红染色和免疫组织化学诊断CA。在全身麻醉下手术切除腭黏膜病变。术后12个月随访，患者愈合良好，无复发迹象。

{"title":"A case of palatal canalicular adenoma","authors":"Hitomi Kajikawa , Yoshihiro Morita , Kaori Oya , Ryotaro Kakimoto , Sho Katsura , Emiko Ogasa , Yukiko Kitahira , Yuka Matsumiya-Matsumoto , Akinori Takeshita , Narikazu Uzawa","doi":"10.1016/j.ajoms.2025.07.009","DOIUrl":"10.1016/j.ajoms.2025.07.009","url":null,"abstract":"<div><div>Canalicular adenoma (CA) is a rare, benign salivary gland tumor accounting for less than 1 % of all salivary gland tumors and 4–6 % of minor salivary gland tumors. We report a case of CA in the palate that was initially suspected to be malignant owing to the appearance of the lesion surface following a laser incision performed at another hospital. A 58-year-old woman presented with swelling of the palatal mucosa in the right maxillary molar area. Computed tomography and magnetic resonance imaging revealed a soft tissue mass; however, because the patient had a history of asthma and non-contrast imaging was selected for these imaging tests, the imaging findings did not differentiate between benign and malignant tumors. A diagnosis of CA was made based on hematoxylin and eosin staining and immunohistochemistry of the biopsy sample. The lesion was surgically removed from the palatal mucosa under general anesthesia. At the 12-month postoperative follow-up, the patient exhibited good healing with no evidence of recurrence.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 183-186"},"PeriodicalIF":0.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-linked hypophosphatemia with multiple radicular cysts: a case report x连锁低磷血症伴多发性根性囊肿1例报告

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-07-09 DOI: 10.1016/j.ajoms.2025.07.007

Katsuhiko Hayashi, Takeshi Takayama, Katsuhito Watanabe, Yuki Sugiyama, Yuri Kirihara

X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by hyperphosphaturia and hypophosphatemia, leading to impaired mineralization and dysplasia of bones and dentin. A 19-year-old man with XLH was referred to our department for diagnosis and treatment of radiolucent lesions in the maxilla and mandible. Panoramic radiography revealed enlarged pulp chambers, thin dentin, wide root canals, and root apex enlargement in all teeth, as characteristic features of XLH, as well as multiple radiolucent lesions involving the roots of teeth in the maxilla and mandible. A biopsy confirmed the diagnosis of radicular cyst. Subsequently, 11 teeth were extracted, and seven cysts were surgically enucleated under general anesthesia. Histopathological examination confirmed the diagnosis of radicular cysts for all seven cysts. Examination of decalcified sections of the extracted left maxillary lateral incisor revealed interglobular dentin, indicating marked dentin hypocalcification. Postoperatively, the patient has remained stable and continues to receive regular dental care at his primary dental clinic. Since XLH is associated with pulpal infection and internal dental fistula formation even in the absence of caries or trauma, close collaboration between dentists and physicians managing patients with XLH is essential from early childhood. Without appropriate oral management, XLH patients can develop apical periodontitis and radicular cysts that require surgical intervention, as observed in the present case.

x连锁低磷血症（XLH）是一种罕见的遗传性疾病，以高磷尿和低磷血症为特征，导致矿化受损和骨骼和牙本质发育不良。一位19岁的男性XLH患者被转介到我科诊断和治疗在上颌骨和下颌骨的放射性病变。全景x线摄影显示，所有牙齿的牙髓腔增大，牙本质薄，根管宽，根尖增大，是XLH的特征，上颌和下颌骨的牙根有多处放射性透光病变。活检证实了根状囊肿的诊断。随后，11颗牙齿被拔除，7个囊肿在全身麻醉下手术摘除。组织病理学检查证实了所有7个囊肿的诊断为根性囊肿。拔除的左上颌侧切牙的脱钙切片检查显示牙本质球间质，表明牙本质明显的低钙化。术后，患者病情稳定，并继续在其初级牙科诊所接受定期牙科护理。由于即使在没有龋齿或外伤的情况下，XLH也与牙髓感染和内牙瘘形成有关，因此牙医和医生从儿童早期开始就必须密切合作，管理XLH患者。如果没有适当的口腔治疗，XLH患者可能会发展为根尖牙周炎和根性囊肿，需要手术干预，正如本病例所观察到的。

{"title":"X-linked hypophosphatemia with multiple radicular cysts: a case report","authors":"Katsuhiko Hayashi, Takeshi Takayama, Katsuhito Watanabe, Yuki Sugiyama, Yuri Kirihara","doi":"10.1016/j.ajoms.2025.07.007","DOIUrl":"10.1016/j.ajoms.2025.07.007","url":null,"abstract":"<div><div>X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by hyperphosphaturia and hypophosphatemia, leading to impaired mineralization and dysplasia of bones and dentin. A 19-year-old man with XLH was referred to our department for diagnosis and treatment of radiolucent lesions in the maxilla and mandible. Panoramic radiography revealed enlarged pulp chambers, thin dentin, wide root canals, and root apex enlargement in all teeth, as characteristic features of XLH, as well as multiple radiolucent lesions involving the roots of teeth in the maxilla and mandible. A biopsy confirmed the diagnosis of radicular cyst. Subsequently, 11 teeth were extracted, and seven cysts were surgically enucleated under general anesthesia. Histopathological examination confirmed the diagnosis of radicular cysts for all seven cysts. Examination of decalcified sections of the extracted left maxillary lateral incisor revealed interglobular dentin, indicating marked dentin hypocalcification. Postoperatively, the patient has remained stable and continues to receive regular dental care at his primary dental clinic. Since XLH is associated with pulpal infection and internal dental fistula formation even in the absence of caries or trauma, close collaboration between dentists and physicians managing patients with XLH is essential from early childhood. Without appropriate oral management, XLH patients can develop apical periodontitis and radicular cysts that require surgical intervention, as observed in the present case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 179-182"},"PeriodicalIF":0.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0