Pub Date : 2024-07-06DOI: 10.1016/j.ajoms.2024.07.005
Giovanna Lopes Carvalho , Juliana Mota Siqueira , Daniele Heguedusch , David Eduardo Zuluaga Liberato , Andressa Teruya Ramos , Emília Maria Gomes Aguiar , Fabio Daumas Nunes
Oral squamous cell carcinoma (OSCC) is a differential diagnosis of subgemmal neurogenous plaque (SNP), however cases of both adjacent lesions is extremely rare. Usually, SNP is associated with severe and persistent pain, a symptom rarely seen in early-stage OSCC. Here, we present a 47-year-old female patient complaining of severe pain upon touch, eating, or drinking in the posterior third of the lateral border of the tongue for one year, which was diagnosed as SNP. However, the symptoms did not decrease, and changed location to the middle third of the lateral border of the tongue, together with the appearance of a new lesion, which was diagnosed as OSCC. While the simultaneous occurrence of OSCC and SNP in the oral cavity is uncommon, pain has been reported as the initial symptom of malignancy in such cases.
{"title":"Subgemmal neurogenous plaque and oral squamous cell carcinoma: Association or coincidence?","authors":"Giovanna Lopes Carvalho , Juliana Mota Siqueira , Daniele Heguedusch , David Eduardo Zuluaga Liberato , Andressa Teruya Ramos , Emília Maria Gomes Aguiar , Fabio Daumas Nunes","doi":"10.1016/j.ajoms.2024.07.005","DOIUrl":"10.1016/j.ajoms.2024.07.005","url":null,"abstract":"<div><div>Oral squamous cell carcinoma (OSCC) is a differential diagnosis of subgemmal neurogenous plaque (SNP), however cases of both adjacent lesions is extremely rare. Usually, SNP is associated with severe and persistent pain, a symptom rarely seen in early-stage OSCC. Here, we present a 47-year-old female patient complaining of severe pain upon touch, eating, or drinking in the posterior third of the lateral border of the tongue for one year, which was diagnosed as SNP. However, the symptoms did not decrease, and changed location to the middle third of the lateral border of the tongue, together with the appearance of a new lesion, which was diagnosed as OSCC. While the simultaneous occurrence of OSCC and SNP in the oral cavity is uncommon, pain has been reported as the initial symptom of malignancy in such cases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 376-379"},"PeriodicalIF":0.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.
{"title":"Two cases of lichen planus in the oral cavity and laryngopharynx","authors":"Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno","doi":"10.1016/j.ajoms.2024.06.009","DOIUrl":"10.1016/j.ajoms.2024.06.009","url":null,"abstract":"<div><div>Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 221-227"},"PeriodicalIF":0.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sialolithiasis of minor salivary gland (SMSG) clinically manifests as an asymptomatic, small, and firm submucosal nodule, and its occurrence in multiple areas is rare. Diagnosing SMSG may be challenging owing to similarities in clinical characteristics with other lesions; misdiagnoses may also occur. In addition to pathological examination, scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDS) analysis can be used to determine the nature of the material. Herein, we report a rare case of a patient with SMSGs in multiple areas of lips, along with SEM-EDS analysis. A 45-year-old female consulted our department with complaints of mild pain and swelling in her lips. Oral examination revealed firm multiple nodules beneath the upper and lower labial mucosa, whereas computed tomography (CT) revealed well-circumscribed multiple hyperdense lesions suggestive of calculi in the upper and lower lips. Following a tentative clinical diagnosis of SMSGs in multiple areas of the lips, three calculi were removed. Histological and SEM-EDS findings supported a final diagnosis of SMSGs. SMSG could be a clinical differential diagnosis of a firm, mobile, and small lip nodule, and SEM-EDS analysis could provide valuable information on the structure and composition of sialoliths. We clinically diagnosed the nodules as SMSGs by careful interpretation of clinical and imaging manifestations. Clinicians should consider SMSG as a clinical differential diagnosis of unknown hard, mobile, and small nodules in lips and buccal mucosa. CT and ultrastructural analysis with SEM and EDS may effectively characterize the sialoliths.
{"title":"Sialolithiasis of minor salivary glands in multiple areas of the lips: Scanning electron microscopy and energy dispersive X-ray spectroscopy analysis","authors":"Takuma Watanabe , Dai Kawahara , Tatsuya Kawamura , Ryo Inoue , Akihiko Yamaguchi , Kazumasa Nakao","doi":"10.1016/j.ajoms.2024.07.002","DOIUrl":"10.1016/j.ajoms.2024.07.002","url":null,"abstract":"<div><div><span><span>Sialolithiasis<span> of minor salivary gland<span> (SMSG) clinically manifests as an asymptomatic, small, and firm submucosal nodule, and its occurrence in multiple areas is rare. Diagnosing SMSG may be challenging owing to similarities in clinical characteristics with other lesions; misdiagnoses may also occur. In addition to pathological examination, scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDS) analysis can be used to determine the nature of the material. Herein, we report a rare case of a patient with SMSGs in multiple areas of lips, along with SEM-EDS analysis. A 45-year-old female consulted our department with complaints of mild pain and swelling in her lips. Oral examination revealed firm multiple nodules beneath the upper and lower labial mucosa, whereas </span></span></span>computed tomography (CT) revealed well-circumscribed multiple hyperdense lesions suggestive of calculi in the upper and lower lips. Following a tentative clinical diagnosis of SMSGs in multiple areas of the lips, three calculi were removed. Histological and SEM-EDS findings supported a final diagnosis of SMSGs. SMSG could be a clinical differential diagnosis of a firm, mobile, and small lip nodule, and SEM-EDS analysis could provide valuable information on the structure and composition of </span>sialoliths<span>. We clinically diagnosed the nodules as SMSGs by careful interpretation of clinical and imaging manifestations. Clinicians should consider SMSG as a clinical differential diagnosis of unknown hard, mobile, and small nodules in lips and buccal mucosa. CT and ultrastructural analysis with SEM and EDS may effectively characterize the sialoliths.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 297-302"},"PeriodicalIF":0.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Among oral pathologic lesions, odontomas are one of the most common odontogenic tumor of the jaw. Odontomas are generally asymptomatic and most cases involve only one region of the maxilla or mandible. An 18-year-old man visited our department for examination and treatment of cystic lesions in the bilateral mandibular retromolar area. Surgery was performed with the patient under general anesthesia for a diagnosis of the lesions. The histopathological diagnosis was immature stages of odontomas, partially including a findings of benign mixed epithelial and mesenchymal odontogenic tumor. These findings suggested the possibility of ameloblastic fibro-odontoma, which was excluded from current WHO classification. It consists of proliferation of odontogenic epithelial and mesenchymal components combined with hard tissues such as dentin and enamel. Recently, the majority of such cases have been identified as immature odontoma. However, because of previous reports of cases of recurrence and malignant transformation, the possibility of a true tumor has not been completely ruled out. Herein, along with a literature review, we report the case of bilateral odontoma containing a findings of benign mixed epithelial and mesenchymal odontogenic tumor in the retromolar region of the mandible.
{"title":"A rare case of bilateral odontoma in the retromolar region of the mandible","authors":"Kengo Hashimoto , Mizuki Hyodo , Yutaro Kondo , Yuya Urano , Masahiro Umemura","doi":"10.1016/j.ajoms.2024.07.003","DOIUrl":"10.1016/j.ajoms.2024.07.003","url":null,"abstract":"<div><div>Among oral pathologic lesions, odontomas are one of the most common odontogenic tumor of the jaw. Odontomas are generally asymptomatic and most cases involve only one region of the maxilla<span><span> or mandible<span>. An 18-year-old man visited our department for examination and treatment of cystic lesions in the bilateral mandibular retromolar area. Surgery was performed with the patient under general anesthesia for a diagnosis of the lesions. The histopathological diagnosis was immature stages of odontomas, partially including a findings of benign mixed epithelial and mesenchymal odontogenic tumor. These findings suggested the possibility of ameloblastic fibro-odontoma, which was excluded from current WHO classification. It consists of proliferation of odontogenic epithelial and mesenchymal components combined with hard tissues such as dentin and enamel. Recently, the majority of such cases have been identified as immature odontoma. However, because of previous reports of cases of recurrence and </span></span>malignant transformation, the possibility of a true tumor has not been completely ruled out. Herein, along with a literature review, we report the case of bilateral odontoma containing a findings of benign mixed epithelial and mesenchymal odontogenic tumor in the retromolar region of the mandible.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 303-307"},"PeriodicalIF":0.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.1016/j.ajoms.2024.07.004
Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos
Objective
To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).
Methods
Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.
Results
At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.
Conclusions
Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.
{"title":"Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease","authors":"Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos","doi":"10.1016/j.ajoms.2024.07.004","DOIUrl":"10.1016/j.ajoms.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).</div></div><div><h3>Methods</h3><div>Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.</div></div><div><h3>Results</h3><div>At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.</div></div><div><h3>Conclusions</h3><div>Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 188-194"},"PeriodicalIF":0.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1016/j.ajoms.2024.06.010
Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos
Objective
This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).
Methods
This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.
Results
Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.
Conclusion
The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.
{"title":"Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review","authors":"Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos","doi":"10.1016/j.ajoms.2024.06.010","DOIUrl":"10.1016/j.ajoms.2024.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).</div></div><div><h3>Methods</h3><div>This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.</div></div><div><h3>Results</h3><div>Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.</div></div><div><h3>Conclusion</h3><div>The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 151-156"},"PeriodicalIF":0.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In surgical orthodontic treatment, the presence of an ankylosed tooth makes it difficult to achieve the desired dental arch morphology. Single tooth osteotomy and dentoalveolar distraction osteogenesis (DO) combined with surgical orthodontic treatment for a patient with jaw deformity and an ankylosed maxillary canine is described in this report. A 37-year-old female was referred to our clinic with a chief complaint of anterior crossbite and was diagnosed with skeletal mandibular protrusion. During preoperative orthodontic treatment for surgical orthodontic treatment, her upper right canine did not move and was diagnosed as an ankylosed tooth. Therefore, we decided to perform a single tooth osteotomy and dentoalveolar DO of the right maxillary canine. Instead of using a commercially available distractor, the dentoalveolar DO in this case was performed using a homemade device with orthodontic biomechanics to move the ankylosed tooth with its supporting alveolar bone and soft tissue into the correct position. After preoperative orthodontic treatment, orthognathic surgery with Le Fort I osteotomy and bilateral sagittal split osteotomies was performed. However, root resorption of the right upper canine continued, and the resorption area was therefore restored with composite resin 10 months after orthognathic surgery to improve the function and esthetics of the maxillofacial region. One and a half years have passed since the orthognathic surgery, and the skeletal stability is good, and the patient is progressing well.
在外科正畸治疗中，由于强直牙的存在，很难达到理想的牙弓形态。本报告描述了对一名患有颌骨畸形和上颌犬牙强直的患者进行单牙截骨术和牙槽骨牵引成骨术（DO）结合外科正畸治疗的情况。一名 37 岁的女性因主诉前交叉咬合而被转诊至我院，并被诊断为下颌骨骼前突。在进行外科正畸治疗的术前正畸治疗期间，她的右上犬齿没有移动，被诊断为强直牙。因此，我们决定对右侧上颌犬齿进行单牙截骨和牙槽骨 DO。在这个病例中，我们没有使用市面上销售的牵引器，而是使用一种自制的具有正畸生物力学原理的装置来进行牙槽骨DO，从而将强直牙及其支持的牙槽骨和软组织移动到正确的位置。术前正畸治疗后，进行了正颌外科手术，包括 Le Fort I 截骨术和双侧矢状劈开截骨术。然而，右上犬齿的牙根吸收仍在继续，因此在正颌手术 10 个月后用复合树脂修复了吸收区，以改善颌面部的功能和美观。正颌手术后一年半过去了，患者的骨骼稳定性良好，进展顺利。
{"title":"Dentoalveolar distraction osteogenesis combined with surgical orthodonthic treatment for a patient with jaw deformity and ankylosed maxillary canine – A case report","authors":"Zhuoyang Zheng, Ryoko Takeuchi, Daisuke Suda, Daisuke Saito, Daichi Hasebe, Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2024.06.007","DOIUrl":"10.1016/j.ajoms.2024.06.007","url":null,"abstract":"<div><div>In surgical orthodontic treatment, the presence of an ankylosed tooth makes it difficult to achieve the desired dental arch morphology. Single tooth osteotomy and dentoalveolar distraction osteogenesis (DO) combined with surgical orthodontic treatment for a patient with jaw deformity and an ankylosed maxillary canine is described in this report. A 37-year-old female was referred to our clinic with a chief complaint of anterior crossbite and was diagnosed with skeletal mandibular protrusion. During preoperative orthodontic treatment for surgical orthodontic treatment, her upper right canine did not move and was diagnosed as an ankylosed tooth. Therefore, we decided to perform a single tooth osteotomy and dentoalveolar DO of the right maxillary canine. Instead of using a commercially available distractor, the dentoalveolar DO in this case was performed using a homemade device with orthodontic biomechanics to move the ankylosed tooth with its supporting alveolar bone and soft tissue into the correct position. After preoperative orthodontic treatment, orthognathic surgery with Le Fort I osteotomy and bilateral sagittal split osteotomies was performed. However, root resorption of the right upper canine continued, and the resorption area was therefore restored with composite resin 10 months after orthognathic surgery to improve the function and esthetics of the maxillofacial region. One and a half years have passed since the orthognathic surgery, and the skeletal stability is good, and the patient is progressing well.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 130-134"},"PeriodicalIF":0.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.ajoms.2024.06.006
Noble T. Baby , Shaji Thomas , R. Rejnish Kumar , Jayasree Kattoor , S. Kannan
Objective
Oral tongue squamous cell carcinoma is one of the most common cancers in the oral cavity. The lack of a signature biomarker to assess the treatment response makes the overall survival rate still less. Cytokeratins are intermediate filaments of the cytoskeleton and shown to be used as a marker to detect circulating tumor cells (CTC) of different carcinomas. The present study aims to evaluate the potential of cytokeratin 19 (CK19) as a marker for CTC in oral tongue squamous cell carcinoma (OTC) patients.
Methods
The expression pattern of CK19 was assessed in peripheral blood mononuclear cells (PBMC) of OTC patients by real-time polymerase chain reaction (RT-PCR) and correlated to various clinico-pathological parameters of patients. The association between various clinico-pathological parameters and the expression of CK19 was evaluated by the Chi-Square Test.
Results
The results suggest that CK19 mRNA level is significantly associated with the clinical stage (P = 0.021) and nodal status (P = 0.011) of patients. Also, a significant association is observed with overall survival (P = 0.017) of the patients with CK19 expression.
Conclusion
The CK19 mRNA expression pattern in peripheral blood may be useful for CTCs monitoring and can be used as a prognostic biomarker for OTC patients.
{"title":"Cytokeratin 19 a potential biomarker for circulating tumor cells in oral tongue squamous cell carcinoma","authors":"Noble T. Baby , Shaji Thomas , R. Rejnish Kumar , Jayasree Kattoor , S. Kannan","doi":"10.1016/j.ajoms.2024.06.006","DOIUrl":"10.1016/j.ajoms.2024.06.006","url":null,"abstract":"<div><h3>Objective</h3><div><span><span><span>Oral tongue squamous cell carcinoma is one of the most common cancers in the </span>oral cavity. The lack of a signature biomarker to assess the treatment response makes the </span>overall survival<span> rate still less. Cytokeratins are </span></span>intermediate filaments<span><span> of the cytoskeleton<span><span> and shown to be used as a marker to detect circulating tumor cells (CTC) of different </span>carcinomas. The present study aims to evaluate the potential of </span></span>cytokeratin 19<span> (CK19) as a marker for CTC in oral tongue squamous cell carcinoma (OTC) patients.</span></span></div></div><div><h3>Methods</h3><div>The expression pattern of CK19 was assessed in peripheral blood mononuclear cells (PBMC) of OTC patients by real-time polymerase chain reaction (RT-PCR) and correlated to various clinico-pathological parameters of patients. The association between various clinico-pathological parameters and the expression of CK19 was evaluated by the Chi-Square Test.</div></div><div><h3>Results</h3><div>The results suggest that CK19 mRNA level is significantly associated with the clinical stage (P = 0.021) and nodal status (P = 0.011) of patients. Also, a significant association is observed with overall survival (P = 0.017) of the patients with CK19 expression.</div></div><div><h3>Conclusion</h3><div>The CK19 mRNA expression pattern in peripheral blood may be useful for CTCs monitoring and can be used as a prognostic biomarker for OTC patients.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 272-277"},"PeriodicalIF":0.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the relationship between the degree of destruction of the cervical lymph node capsule, extranodal invasion distance, and the prognosis of extranodal extension (ENE)-positive patients
Study design
We retrospectively examined microscopic slides from neck dissection specimens of ENE-positive patients of our hospital. The ENE distance was measured by a pathologist who set up a virtual lymph node and measured the maximum extranodal invasion distance. The maximum distance was used for multiple ENEs. Forty patients with ENE were enrolled in this study. The Kaplan–Meier method was used to estimate survival.
Results
Among the ENE-positive cases, the capsule was completely destroyed and partially destroyed in seven and 33 cases, respectively. Disease-specific survival (DSS) was 1251 days (range 156–3009 days). The median distance of extranodal invasion was 2500 µm (392–8500 µm) in the 33 ENE-positive cases in which the capsule was not completely destroyed. Receiver operating characteristic curve analysis of these 33 cases showed that the cutoff value of extranodal invasion distance for progression-free survival was 2241 µm.
Conclusions
ENE is a prognostic predictor of oral cancer; ENE was an independent prognostic factor; and ENE size cutoff of 2241 µm was a significant prognostic factor.
目的研究颈淋巴结囊的破坏程度、结外侵犯距离与结外扩展（ENE）阳性患者预后之间的关系。ENE距离由病理学家测量，病理学家设置了一个虚拟淋巴结，并测量了最大的结外侵袭距离。多个ENE均以最大距离为准。本研究共纳入了 40 例 ENE 患者。结果在ENE阳性病例中，分别有7例和33例的囊完全破坏和部分破坏。疾病特异性生存期（DSS）为1251天（范围为156-3009天）。在 33 例ENE阳性病例中，囊膜未被完全破坏的结节外侵中位距离为 2500 µm（392-8500 µm）。对这33例病例进行的接收者操作特征曲线分析表明，无进展生存期的结节外侵犯距离临界值为2241微米。结论ENE是口腔癌的预后预测因子；ENE是一个独立的预后因子；ENE大小临界值2241微米是一个重要的预后因子。
{"title":"Clinicopathological study on diameter of extranodal extension of cervical metastatic lymph nodes in the prognosis of oral cancer","authors":"Daigo Yoshiga , Naomi Yada , Kazuya Haraguchi , Hironori Fujita , Kenichiro Katsuno , Sho Mitsugi , Norihiko Furuta , Manabu Habu , Masaaki Sasaguri , Kazuhiro Tominaga , Izumi Yoshioka","doi":"10.1016/j.ajoms.2024.06.008","DOIUrl":"10.1016/j.ajoms.2024.06.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the relationship between the degree of destruction of the cervical lymph node capsule, extranodal invasion distance, and the prognosis of extranodal extension (ENE)-positive patients</div></div><div><h3>Study design</h3><div>We retrospectively examined microscopic slides from neck dissection specimens of ENE-positive patients of our hospital. The ENE distance was measured by a pathologist who set up a virtual lymph node and measured the maximum extranodal invasion distance. The maximum distance was used for multiple ENEs. Forty patients with ENE were enrolled in this study. The Kaplan–Meier method was used to estimate survival.</div></div><div><h3>Results</h3><div>Among the ENE-positive cases, the capsule was completely destroyed and partially destroyed in seven and 33 cases, respectively. Disease-specific survival (DSS) was 1251 days (range 156–3009 days). The median distance of extranodal invasion was 2500 µm (392–8500 µm) in the 33 ENE-positive cases in which the capsule was not completely destroyed. Receiver operating characteristic curve analysis of these 33 cases showed that the cutoff value of extranodal invasion distance for progression-free survival was 2241 µm.</div></div><div><h3>Conclusions</h3><div>ENE is a prognostic predictor of oral cancer; ENE was an independent prognostic factor; and ENE size cutoff of 2241 µm was a significant prognostic factor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 64-69"},"PeriodicalIF":0.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1016/j.ajoms.2024.06.005
Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le
Objective
Post-COVID-19-related osteonecrosis of jaws (PCRONJ) has emerged as a complication observed in patients recovered from COVID-19 infection, but PCRONJ has been understudied in the literature. We aimed to report a case series of PCRONJ, including diagnosis, treatment procedures, and discussion about related factors.
Methods
We prospectively evaluated PCRONJ patients at the National Hospital of Odonto-Stomatology in Ho Chi Minh, Vietnam. Patients’ demographics, medical history, COVID-19 treatment, clinical and preclinical features, and clinical outcomes were reported.
Results
During a six-month period, nine patients were included in this study. The mean age was 53.7 years and 56 % of patients were male. All patients were diagnosed with PCRONJ at the maxillary, diabetic and administered corticosteroids to manage COVID-19 prior to this infection. The mean time from COVID-19 recovery to the onset of symptoms was 4.6 weeks. 89 % of patients underwent tooth extractions following tooth mobility examination. Clinically, mobility of dentoalveolar maxillae, in combination with necrotic bone exposure and/or inflammatory signs were observed in all cases. Radiographically, bone destruction located in maxillae and surrounding structures reflected the extension of lesions. Surgical treatment was applied for all cases to debride the necrotic bone. All patients exhibited well-healing, and an improved quality of life after discharge.
Conclusions
PCRONJ should be distinguished from other forms of osteonecrosis of the jaws due to its distinct features. Multiple risk factors complicate the refinement of the likelihood of PCRONJ but warrant awareness for clinicians. An early diagnosis would help to plan a timely treatment and for optimal clinical outcomes.
{"title":"Maxillary osteonecrosis related to post-COVID-19: A report of case series and 6-month follow-up","authors":"Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le","doi":"10.1016/j.ajoms.2024.06.005","DOIUrl":"10.1016/j.ajoms.2024.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>Post-COVID-19-related osteonecrosis of jaws (PCRONJ) has emerged as a complication observed in patients recovered from COVID-19 infection, but PCRONJ has been understudied in the literature. We aimed to report a case series of PCRONJ, including diagnosis, treatment procedures, and discussion about related factors.</div></div><div><h3>Methods</h3><div>We prospectively evaluated PCRONJ patients at the National Hospital of Odonto-Stomatology in Ho Chi Minh, Vietnam. Patients’ demographics, medical history, COVID-19 treatment, clinical and preclinical features, and clinical outcomes were reported.</div></div><div><h3>Results</h3><div>During a six-month period, nine patients were included in this study. The mean age was 53.7 years and 56 % of patients were male. All patients were diagnosed with PCRONJ at the maxillary, diabetic and administered corticosteroids to manage COVID-19 prior to this infection. The mean time from COVID-19 recovery to the onset of symptoms was 4.6 weeks. 89 % of patients underwent tooth extractions following tooth mobility examination. Clinically, mobility of dentoalveolar maxillae, in combination with necrotic bone exposure and/or inflammatory signs were observed in all cases. Radiographically, bone destruction located in maxillae and surrounding structures reflected the extension of lesions. Surgical treatment was applied for all cases to debride the necrotic bone. All patients exhibited well-healing, and an improved quality of life after discharge.</div></div><div><h3>Conclusions</h3><div>PCRONJ should be distinguished from other forms of osteonecrosis of the jaws due to its distinct features. Multiple risk factors complicate the refinement of the likelihood of PCRONJ but warrant awareness for clinicians. An early diagnosis would help to plan a timely treatment and for optimal clinical outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 180-187"},"PeriodicalIF":0.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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