Pub Date : 2024-07-19DOI: 10.1016/j.ajoms.2024.07.008
Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch
Objective
The aim of the present study was to survey the scientific literature for conclusive evidence about the capacity of ubiquinone to improve the healing process of soft and hard jaw tissue.
Methods
A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was undertaken in six databases and in the gray literature.
Results
Eight studies were identified, four of them in vitro, three in vivo, and one clinical. All articles demonstrated that ubiquinone accelerates the repair of soft tissue, whereas one study found little effect on the remodeling of bone tissue. Despite the possibility that ubiquinone application may be beneficial, the limited knowledge about the action of this coenzyme on oral tissue repair requires further preclinical studies before the development of human clinical trials.
Conclusion
This systematic review provides valuable information about potential new medications that could help the healing of oral tissues, especially for oral and maxillofacial surgeons.
{"title":"The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review","authors":"Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch","doi":"10.1016/j.ajoms.2024.07.008","DOIUrl":"10.1016/j.ajoms.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to survey the scientific literature for conclusive evidence about the capacity of ubiquinone to improve the healing process of soft and hard jaw tissue.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was undertaken in six databases and in the gray literature<strong>.</strong></div></div><div><h3>Results</h3><div>Eight studies were identified, four of them <em>in vitro,</em> three <em>in vivo,</em> and one clinical. All articles demonstrated that ubiquinone accelerates the repair of soft tissue, whereas one study found little effect on the remodeling of bone tissue. Despite the possibility that ubiquinone application may be beneficial, the limited knowledge about the action of this coenzyme on oral tissue repair requires further preclinical studies before the development of human clinical trials.</div></div><div><h3>Conclusion</h3><div>This systematic review provides valuable information about potential new medications that could help the healing of oral tissues, especially for oral and maxillofacial surgeons.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 157-166"},"PeriodicalIF":0.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.
{"title":"Two cases of lichen planus in the oral cavity and laryngopharynx","authors":"Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno","doi":"10.1016/j.ajoms.2024.06.009","DOIUrl":"10.1016/j.ajoms.2024.06.009","url":null,"abstract":"<div><div>Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 221-227"},"PeriodicalIF":0.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.1016/j.ajoms.2024.07.004
Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos
Objective
To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).
Methods
Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.
Results
At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.
Conclusions
Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.
{"title":"Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease","authors":"Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos","doi":"10.1016/j.ajoms.2024.07.004","DOIUrl":"10.1016/j.ajoms.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).</div></div><div><h3>Methods</h3><div>Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.</div></div><div><h3>Results</h3><div>At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.</div></div><div><h3>Conclusions</h3><div>Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 188-194"},"PeriodicalIF":0.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1016/j.ajoms.2024.06.010
Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos
Objective
This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).
Methods
This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.
Results
Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.
Conclusion
The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.
{"title":"Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review","authors":"Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos","doi":"10.1016/j.ajoms.2024.06.010","DOIUrl":"10.1016/j.ajoms.2024.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).</div></div><div><h3>Methods</h3><div>This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.</div></div><div><h3>Results</h3><div>Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.</div></div><div><h3>Conclusion</h3><div>The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 151-156"},"PeriodicalIF":0.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In surgical orthodontic treatment, the presence of an ankylosed tooth makes it difficult to achieve the desired dental arch morphology. Single tooth osteotomy and dentoalveolar distraction osteogenesis (DO) combined with surgical orthodontic treatment for a patient with jaw deformity and an ankylosed maxillary canine is described in this report. A 37-year-old female was referred to our clinic with a chief complaint of anterior crossbite and was diagnosed with skeletal mandibular protrusion. During preoperative orthodontic treatment for surgical orthodontic treatment, her upper right canine did not move and was diagnosed as an ankylosed tooth. Therefore, we decided to perform a single tooth osteotomy and dentoalveolar DO of the right maxillary canine. Instead of using a commercially available distractor, the dentoalveolar DO in this case was performed using a homemade device with orthodontic biomechanics to move the ankylosed tooth with its supporting alveolar bone and soft tissue into the correct position. After preoperative orthodontic treatment, orthognathic surgery with Le Fort I osteotomy and bilateral sagittal split osteotomies was performed. However, root resorption of the right upper canine continued, and the resorption area was therefore restored with composite resin 10 months after orthognathic surgery to improve the function and esthetics of the maxillofacial region. One and a half years have passed since the orthognathic surgery, and the skeletal stability is good, and the patient is progressing well.
在外科正畸治疗中，由于强直牙的存在，很难达到理想的牙弓形态。本报告描述了对一名患有颌骨畸形和上颌犬牙强直的患者进行单牙截骨术和牙槽骨牵引成骨术（DO）结合外科正畸治疗的情况。一名 37 岁的女性因主诉前交叉咬合而被转诊至我院，并被诊断为下颌骨骼前突。在进行外科正畸治疗的术前正畸治疗期间，她的右上犬齿没有移动，被诊断为强直牙。因此，我们决定对右侧上颌犬齿进行单牙截骨和牙槽骨 DO。在这个病例中，我们没有使用市面上销售的牵引器，而是使用一种自制的具有正畸生物力学原理的装置来进行牙槽骨DO，从而将强直牙及其支持的牙槽骨和软组织移动到正确的位置。术前正畸治疗后，进行了正颌外科手术，包括 Le Fort I 截骨术和双侧矢状劈开截骨术。然而，右上犬齿的牙根吸收仍在继续，因此在正颌手术 10 个月后用复合树脂修复了吸收区，以改善颌面部的功能和美观。正颌手术后一年半过去了，患者的骨骼稳定性良好，进展顺利。
{"title":"Dentoalveolar distraction osteogenesis combined with surgical orthodonthic treatment for a patient with jaw deformity and ankylosed maxillary canine – A case report","authors":"Zhuoyang Zheng, Ryoko Takeuchi, Daisuke Suda, Daisuke Saito, Daichi Hasebe, Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2024.06.007","DOIUrl":"10.1016/j.ajoms.2024.06.007","url":null,"abstract":"<div><div>In surgical orthodontic treatment, the presence of an ankylosed tooth makes it difficult to achieve the desired dental arch morphology. Single tooth osteotomy and dentoalveolar distraction osteogenesis (DO) combined with surgical orthodontic treatment for a patient with jaw deformity and an ankylosed maxillary canine is described in this report. A 37-year-old female was referred to our clinic with a chief complaint of anterior crossbite and was diagnosed with skeletal mandibular protrusion. During preoperative orthodontic treatment for surgical orthodontic treatment, her upper right canine did not move and was diagnosed as an ankylosed tooth. Therefore, we decided to perform a single tooth osteotomy and dentoalveolar DO of the right maxillary canine. Instead of using a commercially available distractor, the dentoalveolar DO in this case was performed using a homemade device with orthodontic biomechanics to move the ankylosed tooth with its supporting alveolar bone and soft tissue into the correct position. After preoperative orthodontic treatment, orthognathic surgery with Le Fort I osteotomy and bilateral sagittal split osteotomies was performed. However, root resorption of the right upper canine continued, and the resorption area was therefore restored with composite resin 10 months after orthognathic surgery to improve the function and esthetics of the maxillofacial region. One and a half years have passed since the orthognathic surgery, and the skeletal stability is good, and the patient is progressing well.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 130-134"},"PeriodicalIF":0.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the relationship between the degree of destruction of the cervical lymph node capsule, extranodal invasion distance, and the prognosis of extranodal extension (ENE)-positive patients
Study design
We retrospectively examined microscopic slides from neck dissection specimens of ENE-positive patients of our hospital. The ENE distance was measured by a pathologist who set up a virtual lymph node and measured the maximum extranodal invasion distance. The maximum distance was used for multiple ENEs. Forty patients with ENE were enrolled in this study. The Kaplan–Meier method was used to estimate survival.
Results
Among the ENE-positive cases, the capsule was completely destroyed and partially destroyed in seven and 33 cases, respectively. Disease-specific survival (DSS) was 1251 days (range 156–3009 days). The median distance of extranodal invasion was 2500 µm (392–8500 µm) in the 33 ENE-positive cases in which the capsule was not completely destroyed. Receiver operating characteristic curve analysis of these 33 cases showed that the cutoff value of extranodal invasion distance for progression-free survival was 2241 µm.
Conclusions
ENE is a prognostic predictor of oral cancer; ENE was an independent prognostic factor; and ENE size cutoff of 2241 µm was a significant prognostic factor.
目的研究颈淋巴结囊的破坏程度、结外侵犯距离与结外扩展（ENE）阳性患者预后之间的关系。ENE距离由病理学家测量，病理学家设置了一个虚拟淋巴结，并测量了最大的结外侵袭距离。多个ENE均以最大距离为准。本研究共纳入了 40 例 ENE 患者。结果在ENE阳性病例中，分别有7例和33例的囊完全破坏和部分破坏。疾病特异性生存期（DSS）为1251天（范围为156-3009天）。在 33 例ENE阳性病例中，囊膜未被完全破坏的结节外侵中位距离为 2500 µm（392-8500 µm）。对这33例病例进行的接收者操作特征曲线分析表明，无进展生存期的结节外侵犯距离临界值为2241微米。结论ENE是口腔癌的预后预测因子；ENE是一个独立的预后因子；ENE大小临界值2241微米是一个重要的预后因子。
{"title":"Clinicopathological study on diameter of extranodal extension of cervical metastatic lymph nodes in the prognosis of oral cancer","authors":"Daigo Yoshiga , Naomi Yada , Kazuya Haraguchi , Hironori Fujita , Kenichiro Katsuno , Sho Mitsugi , Norihiko Furuta , Manabu Habu , Masaaki Sasaguri , Kazuhiro Tominaga , Izumi Yoshioka","doi":"10.1016/j.ajoms.2024.06.008","DOIUrl":"10.1016/j.ajoms.2024.06.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the relationship between the degree of destruction of the cervical lymph node capsule, extranodal invasion distance, and the prognosis of extranodal extension (ENE)-positive patients</div></div><div><h3>Study design</h3><div>We retrospectively examined microscopic slides from neck dissection specimens of ENE-positive patients of our hospital. The ENE distance was measured by a pathologist who set up a virtual lymph node and measured the maximum extranodal invasion distance. The maximum distance was used for multiple ENEs. Forty patients with ENE were enrolled in this study. The Kaplan–Meier method was used to estimate survival.</div></div><div><h3>Results</h3><div>Among the ENE-positive cases, the capsule was completely destroyed and partially destroyed in seven and 33 cases, respectively. Disease-specific survival (DSS) was 1251 days (range 156–3009 days). The median distance of extranodal invasion was 2500 µm (392–8500 µm) in the 33 ENE-positive cases in which the capsule was not completely destroyed. Receiver operating characteristic curve analysis of these 33 cases showed that the cutoff value of extranodal invasion distance for progression-free survival was 2241 µm.</div></div><div><h3>Conclusions</h3><div>ENE is a prognostic predictor of oral cancer; ENE was an independent prognostic factor; and ENE size cutoff of 2241 µm was a significant prognostic factor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 64-69"},"PeriodicalIF":0.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1016/j.ajoms.2024.06.005
Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le
Objective
Post-COVID-19-related osteonecrosis of jaws (PCRONJ) has emerged as a complication observed in patients recovered from COVID-19 infection, but PCRONJ has been understudied in the literature. We aimed to report a case series of PCRONJ, including diagnosis, treatment procedures, and discussion about related factors.
Methods
We prospectively evaluated PCRONJ patients at the National Hospital of Odonto-Stomatology in Ho Chi Minh, Vietnam. Patients’ demographics, medical history, COVID-19 treatment, clinical and preclinical features, and clinical outcomes were reported.
Results
During a six-month period, nine patients were included in this study. The mean age was 53.7 years and 56 % of patients were male. All patients were diagnosed with PCRONJ at the maxillary, diabetic and administered corticosteroids to manage COVID-19 prior to this infection. The mean time from COVID-19 recovery to the onset of symptoms was 4.6 weeks. 89 % of patients underwent tooth extractions following tooth mobility examination. Clinically, mobility of dentoalveolar maxillae, in combination with necrotic bone exposure and/or inflammatory signs were observed in all cases. Radiographically, bone destruction located in maxillae and surrounding structures reflected the extension of lesions. Surgical treatment was applied for all cases to debride the necrotic bone. All patients exhibited well-healing, and an improved quality of life after discharge.
Conclusions
PCRONJ should be distinguished from other forms of osteonecrosis of the jaws due to its distinct features. Multiple risk factors complicate the refinement of the likelihood of PCRONJ but warrant awareness for clinicians. An early diagnosis would help to plan a timely treatment and for optimal clinical outcomes.
{"title":"Maxillary osteonecrosis related to post-COVID-19: A report of case series and 6-month follow-up","authors":"Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le","doi":"10.1016/j.ajoms.2024.06.005","DOIUrl":"10.1016/j.ajoms.2024.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>Post-COVID-19-related osteonecrosis of jaws (PCRONJ) has emerged as a complication observed in patients recovered from COVID-19 infection, but PCRONJ has been understudied in the literature. We aimed to report a case series of PCRONJ, including diagnosis, treatment procedures, and discussion about related factors.</div></div><div><h3>Methods</h3><div>We prospectively evaluated PCRONJ patients at the National Hospital of Odonto-Stomatology in Ho Chi Minh, Vietnam. Patients’ demographics, medical history, COVID-19 treatment, clinical and preclinical features, and clinical outcomes were reported.</div></div><div><h3>Results</h3><div>During a six-month period, nine patients were included in this study. The mean age was 53.7 years and 56 % of patients were male. All patients were diagnosed with PCRONJ at the maxillary, diabetic and administered corticosteroids to manage COVID-19 prior to this infection. The mean time from COVID-19 recovery to the onset of symptoms was 4.6 weeks. 89 % of patients underwent tooth extractions following tooth mobility examination. Clinically, mobility of dentoalveolar maxillae, in combination with necrotic bone exposure and/or inflammatory signs were observed in all cases. Radiographically, bone destruction located in maxillae and surrounding structures reflected the extension of lesions. Surgical treatment was applied for all cases to debride the necrotic bone. All patients exhibited well-healing, and an improved quality of life after discharge.</div></div><div><h3>Conclusions</h3><div>PCRONJ should be distinguished from other forms of osteonecrosis of the jaws due to its distinct features. Multiple risk factors complicate the refinement of the likelihood of PCRONJ but warrant awareness for clinicians. An early diagnosis would help to plan a timely treatment and for optimal clinical outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 180-187"},"PeriodicalIF":0.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to evaluate the usefulness of bioresorbable miniplates by comparing the three-dimensional maxillary stability of poly L-lactic acid and titanium miniplate systems in Le Fort I osteotomy.
Methods
Fifty patients with jaw deformities underwent Le Fort I or bilateral sagittal split osteotomies. The patients were divided into two groups: the first group received the polylactic acid miniplate system for bone fixation, while the second group received the titanium miniplate system. Cone-beam computed tomography (CBCT) was performed before surgery and at 1 and 6 months after surgery. The acquired images were overlapped to quantify the extent of maxillary relapse by calculating the difference in the distance moved between 1 and 6 months after surgery.
Results
There was no significant difference in maxillary stability between the two groups 6 months after surgery.
Conclusions
The postoperative stability achieved using the poly L-lactic acid miniplate system for maxillary fixation was comparable to that achieved using the titanium miniplate system.
方法50例下颌畸形患者接受了Le Fort I或双侧矢状劈开截骨术。患者被分为两组：第一组接受聚乳酸迷你板系统进行骨固定，第二组接受钛迷你板系统。在术前、术后 1 个月和 6 个月时进行锥形束计算机断层扫描（CBCT）。结果两组患者术后 6 个月的上颌骨稳定性无明显差异。结论使用聚左旋乳酸迷你板系统进行上颌骨固定的术后稳定性与使用钛迷你板系统的术后稳定性相当。
{"title":"Comparative three-dimensional maxillary stability assessment: Bioresorbable miniplate vs. titanium miniplate systems in Le Fort I osteotomy","authors":"Koki Takamatsu , Sunao Shiogama , Yosuke Ikehata , Arisa Yasuda , Yuji Kurihara , Tatsuo Shirota","doi":"10.1016/j.ajoms.2024.06.003","DOIUrl":"10.1016/j.ajoms.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the usefulness of bioresorbable miniplates by comparing the three-dimensional maxillary stability of poly L-lactic acid and titanium miniplate systems in Le Fort I osteotomy.</div></div><div><h3>Methods</h3><div>Fifty patients with jaw deformities underwent Le Fort I or bilateral sagittal split osteotomies. The patients were divided into two groups: the first group received the polylactic acid miniplate system for bone fixation, while the second group received the titanium miniplate system. Cone-beam computed tomography (CBCT) was performed before surgery and at 1 and 6 months after surgery. The acquired images were overlapped to quantify the extent of maxillary relapse by calculating the difference in the distance moved between 1 and 6 months after surgery.</div></div><div><h3>Results</h3><div>There was no significant difference in maxillary stability between the two groups 6 months after surgery.</div></div><div><h3>Conclusions</h3><div>The postoperative stability achieved using the poly L-lactic acid miniplate system for maxillary fixation was comparable to that achieved using the titanium miniplate system.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 56-63"},"PeriodicalIF":0.4,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ewing sarcoma (ES) is a rare malignant tumor, particularly in the head and neck region. Its incidence tends to be higher in pediatric patients than in adults. Occasionally, curative treatment of ES requires extensive resection of the primary lesion, which can result in postoperative aesthetic or functional disorders. In recent years, advances have been made in reconstructive surgery of the maxillofacial region. Broad mandibular defects are a prime indication for several types of vascularized free bone grafts. Similarly, the treatment of ES has progressed in the field of systemic chemotherapy. We report a multidisciplinary surgical case of ES in the mandible of a 12-year-old patient who underwent extensive mandibular resection and fibula free flap (FFF) reconstruction with preoperative and postoperative chemotherapy. In brief, after conducting a multidisciplinary clinical conference, perioperative chemotherapy was planned by pediatric oncologists, and the operation was performed by a head and neck cancer team consisting of head and neck, oral and maxillofacial, and plastic surgeons. Five months after the operation, prosthodontists applied an intraoral prosthesis. The reconstructed mandible demonstrated good development, and the quality of life was maintained both aesthetically and functionally for eight years after treatment. Our efficient multidisciplinary medical collaboration demonstrated that mandibular reconstruction using FFF is a suitable method for treating pediatric patients and leads to long-term survival with satisfactory outcomes.
尤文肉瘤（ES）是一种罕见的恶性肿瘤，尤其多发于头颈部。儿童患者的发病率往往高于成人。根治性治疗 ES 有时需要对原发病灶进行大面积切除，这可能会导致术后美观或功能障碍。近年来，颌面部整形手术取得了长足的进步。下颌骨宽大缺损是多种血管化游离骨移植的主要适应症。同样，ES 的治疗在全身化疗领域也取得了进展。我们报告了一例 12 岁下颌骨 ES 的多学科手术病例，患者接受了广泛的下颌骨切除术和腓骨游离瓣（FFF）重建术，并接受了术前和术后化疗。简而言之，在召开多学科临床会议后，儿科肿瘤专家制定了围手术期化疗计划，由头颈部、口腔颌面部和整形外科医生组成的头颈部癌症团队实施了手术。手术五个月后，口腔修复医生为患者安装了口内假牙。重建后的下颌骨发育良好，治疗后八年的生活质量在美观和功能上都得以保持。我们高效的多学科医疗合作证明，使用 FFF 重建下颌骨是治疗儿童患者的一种合适方法，并能带来令人满意的长期生存效果。
{"title":"Segmental mandibular resection and reconstruction using a multidisciplinary approach in adolescent and young adult patients: A case of Ewing sarcoma with a eight-year follow-up","authors":"Sumitaka Hagiwara , Ikuo Hyodo , Daisuke Nishikawa , Masashi Ando , Naoko Maeda , Shogo Ozawa , Yasuhisa Hasegawa , Nobuhiro Hanai","doi":"10.1016/j.ajoms.2024.06.002","DOIUrl":"10.1016/j.ajoms.2024.06.002","url":null,"abstract":"<div><div>Ewing sarcoma (ES) is a rare malignant tumor, particularly in the head and neck region. Its incidence tends to be higher in pediatric patients than in adults. Occasionally, curative treatment of ES requires extensive resection of the primary lesion, which can result in postoperative aesthetic or functional disorders. In recent years, advances have been made in reconstructive surgery of the maxillofacial region. Broad mandibular defects are a prime indication for several types of vascularized free bone grafts. Similarly, the treatment of ES has progressed in the field of systemic chemotherapy. We report a multidisciplinary surgical case of ES in the mandible of a 12-year-old patient who underwent extensive mandibular resection and fibula free flap (FFF) reconstruction with preoperative and postoperative chemotherapy. In brief, after conducting a multidisciplinary clinical conference, perioperative chemotherapy was planned by pediatric oncologists, and the operation was performed by a head and neck cancer team consisting of head and neck, oral and maxillofacial, and plastic surgeons. Five months after the operation, prosthodontists applied an intraoral prosthesis. The reconstructed mandible demonstrated good development, and the quality of life was maintained both aesthetically and functionally for eight years after treatment. Our efficient multidisciplinary medical collaboration demonstrated that mandibular reconstruction using FFF is a suitable method for treating pediatric patients and leads to long-term survival with satisfactory outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 123-129"},"PeriodicalIF":0.4,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-14DOI: 10.1016/j.ajoms.2024.06.001
Hu Longfei, Zhou Shangyin, Zhang Ju
Objective
Radiotherapy combined with chemotherapy or radiotherapy alone is an important treatment for locally advanced oral squamous cell carcinoma. We performed a meta-analysis of published reports about these two treatments.
Methods
We performed an extensive exploration of various databases, such as Embase, PubMed, and the Cochrane Library. The study included research on the comparison between postoperative chemoradiotherapy (POCRT) and postoperative radiotherapy (PORT) for oral cancer, with a restriction on the search language to English. The included endpoints consisted of disease-free survival (DFS), overall survival (OS), locoregional control (LRC), and distant metastasis-free survival (DMFS).
Results
Sixteen studies were included, including 3 prospective studies and 13 retrospective studies, with 3364 patients. For patients with locally advanced oral cancer, compared with PORT, POCRT had better DFS (HR 0.64; 95 % confidence interval [CI],0.48–0.84; P = 0.001), OS (HR 0.76;95 %CI 0.65–0.89; P = 0.0005), and LRC (HR 0.65;95 %CI 0.44–0.95; P = 0.02). There was a tendency for DMFS (RR 0.95;95 %CI 0.90–1.01; P = 0.09) to exhibit a marginal statistical distinction. The risks of grade 3 or higher acute toxicity, such as oral mucositis (RR 1.36; p = 0.44), dysphagia (RR 1.57; p = 0.13), and severe skin (RR 0.71; p = 0.17), were more frequent in the POCRT group, but the difference was not statistically significant.
Conclusions
For patients with oral squamous cell carcinoma, POCRT is beneficial in terms of DFS, OS, and LRC, but there is no significant benefit in DMFS. The group receiving POCRT exhibited a slightly increased likelihood of experiencing oral mucositis and dysphagia, although the disparity did not attain statistical significance.
{"title":"Outcomes of postoperative radiotherapy combined with or without chemotherapy for locally advanced oral cancer: A systematic review and meta-analysis","authors":"Hu Longfei, Zhou Shangyin, Zhang Ju","doi":"10.1016/j.ajoms.2024.06.001","DOIUrl":"10.1016/j.ajoms.2024.06.001","url":null,"abstract":"<div><h3>Objective</h3><div>Radiotherapy combined with chemotherapy or radiotherapy alone is an important treatment for locally advanced oral squamous cell carcinoma. We performed a meta-analysis of published reports about these two treatments.</div></div><div><h3>Methods</h3><div>We performed an extensive exploration of various databases, such as Embase, PubMed, and the Cochrane Library. The study included research on the comparison between postoperative chemoradiotherapy (POCRT) and postoperative radiotherapy (PORT) for oral cancer, with a restriction on the search language to English. The included endpoints consisted of disease-free survival (DFS), overall survival (OS), locoregional control (LRC), and distant metastasis-free survival (DMFS).</div></div><div><h3>Results</h3><div>Sixteen studies were included, including 3 prospective studies and 13 retrospective studies, with 3364 patients. For patients with locally advanced oral cancer, compared with PORT, POCRT had better DFS (HR 0.64; 95 % confidence interval [CI],0.48–0.84; P = 0.001), OS (HR 0.76;95 %CI 0.65–0.89; P = 0.0005), and LRC (HR 0.65;95 %CI 0.44–0.95; P = 0.02). There was a tendency for DMFS (RR 0.95;95 %CI 0.90–1.01; P = 0.09) to exhibit a marginal statistical distinction. The risks of grade 3 or higher acute toxicity, such as oral mucositis (RR 1.36; p = 0.44), dysphagia (RR 1.57; p = 0.13), and severe skin (RR 0.71; p = 0.17), were more frequent in the POCRT group, but the difference was not statistically significant.</div></div><div><h3>Conclusions</h3><div>For patients with oral squamous cell carcinoma, POCRT is beneficial in terms of DFS, OS, and LRC, but there is no significant benefit in DMFS. The group receiving POCRT exhibited a slightly increased likelihood of experiencing oral mucositis and dysphagia, although the disparity did not attain statistical significance.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 141-150"},"PeriodicalIF":0.4,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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