In our clinic, mandibular reconstruction using a custom-made titanium mesh tray (Ti-mesh tray) and autogenous particular cancellous bone and marrow (PCBM) has been performed for the patients, who undergone segmental mandibulectomy, and we could follow up a pediatric patient for 14 years. The patient was an 11-year-old girl with a large benign mandibular tumor. We applied a segmental mandibulectomy and immediately mandibular reconstruction using a Ti-mesh tray and autogenous PCBM harvested from the iliac crest. Subsequently, she underwent occlusal rehabilitation with dental implants, and her good facial appearance and jaw function including occlusal condition were established. At her age of 25 years old, they were maintained, and no growth disturbances were observed in either donor and recipient sites. In this paper, we report on her long-term clinical course.
{"title":"Mandibular reconstruction with particulate cancellous bone and marrow and a custom-made titanium mesh tray followed by occlusal rehabilitation with dental implants: Long-term clinical course of a pediatric case undergone segmental mandibulectomy","authors":"Kazutoshi Nakaoka , Shusuke Yamada , Koichiro Sato , Tadatoshi Ishizuka , Hideki Hojo , Yoshiki Hamada","doi":"10.1016/j.ajoms.2025.09.006","DOIUrl":"10.1016/j.ajoms.2025.09.006","url":null,"abstract":"<div><div>In our clinic, mandibular reconstruction using a custom-made titanium mesh tray (Ti-mesh tray) and autogenous particular cancellous bone and marrow (PCBM) has been performed for the patients, who undergone segmental mandibulectomy, and we could follow up a pediatric patient for 14 years. The patient was an 11-year-old girl with a large benign mandibular tumor. We applied a segmental mandibulectomy and immediately mandibular reconstruction using a Ti-mesh tray and autogenous PCBM harvested from the iliac crest. Subsequently, she underwent occlusal rehabilitation with dental implants, and her good facial appearance and jaw function including occlusal condition were established. At her age of 25 years old, they were maintained, and no growth disturbances were observed in either donor and recipient sites. In this paper, we report on her long-term clinical course.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 262-266"},"PeriodicalIF":0.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enhancing the peri-implant phenotype increases the possibility of long-term favourable outcomes by offering stable peri-implant tissue support, which is essential for the restoration's aesthetic and functional value. The current study aims to investigate the effect non-invasive method of using injectable platelet rich fibrin (iPRF) with micro-needling (MN) on peri-implant mucosal thickness (PIMT) and keratinized mucosal width (KMW) in participants with thin per-implant phenotype.
Methods
This prospective clinical trial included 15 endosseous dental implants with thin peri-implant phenotype(<0.8 mm). iPRF injection with microneedling was done during three sessions ten days apart. PIMT and KMW were measured at baseline, 3- and 6-months post-treatment. Pink Esthetic Score(PES) and Patient Esthetic Score(VAS) were assessed at Baseline, 3- and 6-Months. Pain Score(VAS) was assessed at Baseline, 1-and 2- Weeks.Inferential statistical analyses were done using repeated measures of ANOVA followed by Bonferroni post hoc test.
Results
The intra group comparison of PIMT at 2, 4 mm showed a statistically significant improvement from baseline (0.56 ± 0.06, 0.72 ± 0.07) to 6 Months (1.31 ± 0.26, 1.48 ± 0.32) (p = <0.001).The KMW showed significant increase from baseline (1.66 ± 0.25) to 3months (1.92 ± 0.12) and 6 months(1.98 ± 0.07)(p = <0.001). Patient reported outcomes showed significant improvement by the end of study period.
Conclusions
iPRF + MN is a potentially effective non-surgical, minimally invasive technique to enhance PIMT.
{"title":"Injectable platelet rich fibrin with microneedling in enhancing peri-implant mucosal phenotype - A prospective clinical trial","authors":"Poornima chittabathina , Sruthima NVS Gottumukkala , Gautami S. Penmetsa , Satyanarayana Raju Mantena , Konathala SV Ramesh , Mohan Kumar Pasupuleti , Anil Kumar Kanakamedala","doi":"10.1016/j.ajoms.2025.09.008","DOIUrl":"10.1016/j.ajoms.2025.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>Enhancing the peri-implant phenotype increases the possibility of long-term favourable outcomes by offering stable peri-implant tissue support, which is essential for the restoration's aesthetic and functional value. The current study aims to investigate the effect non-invasive method of using injectable platelet rich fibrin (iPRF) with micro-needling (MN) on peri-implant mucosal thickness (PIMT) and keratinized mucosal width (KMW) in participants with thin per-implant phenotype.</div></div><div><h3>Methods</h3><div>This prospective clinical trial included 15 endosseous dental implants with thin peri-implant phenotype(<0.8 mm). iPRF injection with microneedling was done during three sessions ten days apart. PIMT and KMW were measured at baseline, 3- and 6-months post-treatment. Pink Esthetic Score(PES) and Patient Esthetic Score(VAS) were assessed at Baseline, 3- and 6-Months. Pain Score(VAS) was assessed at Baseline, 1-and 2- Weeks.Inferential statistical analyses were done using repeated measures of ANOVA followed by Bonferroni post hoc test.</div></div><div><h3>Results</h3><div>The intra group comparison of PIMT at 2, 4 mm showed a statistically significant improvement from baseline (0.56 ± 0.06, 0.72 ± 0.07) to 6 Months (1.31 ± 0.26, 1.48 ± 0.32) (p = <0.001).The KMW showed significant increase from baseline (1.66 ± 0.25) to 3months (1.92 ± 0.12) and 6 months(1.98 ± 0.07)(p = <0.001). Patient reported outcomes showed significant improvement by the end of study period.</div></div><div><h3>Conclusions</h3><div>iPRF + MN is a potentially effective non-surgical, minimally invasive technique to enhance PIMT.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 215-221"},"PeriodicalIF":0.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-12DOI: 10.1016/j.ajoms.2025.09.002
Katheleen Miranda dos Santos , Michelle Nascimento Meger , Mainara Bassetto , João Armando Brancher , Aline Monise Sebastiani , Rafaela Scariot
Objective
To evaluate the association between the improvement in perception of OHRQoL after orthognathic surgery with genetic polymorphisms.
Materials and methods
This study included 112 patients with dentofacial deformity (DFD) who underwent orthognathic surgery. All patients were assessed preoperatively and 6 months after surgery. The Oral Health Impact Profile (OHIP-14) was applied and oral mucosa cells were collected for DNA extraction. The COMT (rs165656 and rs174675), HTR2A (rs6313 and rs4941573) and MTNR1A (rs13140012, rs6553010 and rs6847693) genes were genotyped with real-time PCR. Evolution in perception of QoL was classified into improvement, same and worsening. Results obtained were submitted to statistical analysis (CI 95 %).
Results
There was an association of COMT with the psychological disability domain in the rs165656 polymorphism (p = 0.042). HTR2A gene in the rs6313 and rs4941573 polymorphism was associated with the social disability domain (p < 0.019; p < 0.038 respectively). There was an association between MTNR1A and the social handicap domain in the recessive G model of rs165656 (p < 0.042).
Conclusion
Genetic factors are involved on the evolution OHRQoL. The COMT, HTR2A and MTNR1A genes are associated with the perception of OHRQoL in the domains related to psychological disability, social disability and social handicap.
{"title":"Evolution of quality of life related to oral health after orthognathic surgery and polymorphisms in the COMT, HTR2A and MTNR1A genes","authors":"Katheleen Miranda dos Santos , Michelle Nascimento Meger , Mainara Bassetto , João Armando Brancher , Aline Monise Sebastiani , Rafaela Scariot","doi":"10.1016/j.ajoms.2025.09.002","DOIUrl":"10.1016/j.ajoms.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between the improvement in perception of OHRQoL after orthognathic surgery with genetic polymorphisms.</div></div><div><h3>Materials and methods</h3><div>This study included 112 patients with dentofacial deformity (DFD) who underwent orthognathic surgery. All patients were assessed preoperatively and 6 months after surgery. The Oral Health Impact Profile (OHIP-14) was applied and oral mucosa cells were collected for DNA extraction. The <em>COMT</em> (rs165656 and rs174675), <em>HTR2A</em> (rs6313 and rs4941573) and <em>MTNR1A</em> (rs13140012, rs6553010 and rs6847693) <em>genes</em> were genotyped with real-time PCR. Evolution in perception of QoL was classified into improvement, same and worsening. Results obtained were submitted to statistical analysis (CI 95 %).</div></div><div><h3>Results</h3><div>There was an association of <em>COMT</em> with the psychological disability domain in the rs165656 polymorphism (<em>p</em> = 0.042). <em>HTR2A gene</em> in the rs6313 and rs4941573 polymorphism was associated with the social disability domain (<em>p</em> < 0.019; <em>p</em> < 0.038 respectively). There was an association between <em>MTNR1A</em> and the social handicap domain in the recessive G model of rs165656 (<em>p</em> < 0.042).</div></div><div><h3>Conclusion</h3><div>Genetic factors are involved on the evolution OHRQoL. The <em>COMT</em>, <em>HTR2A</em> and <em>MTNR1A genes</em> are associated with the perception of OHRQoL in the domains related to psychological disability, social disability and social handicap.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 196-200"},"PeriodicalIF":0.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients undergoing fixed orthodontic treatment are at high risk of gingivitis and periodontal problems; therefore, regular disinfection of orthodontic appliances and rims is necessary to maintain oral health. As common chemical mouthwashes often lead to sensitivity and mucosal lesions, the present study aimed to evaluate the effect of Protact mouthwash containing the extract of Zataria multiflora (ZM) on Streptococcus mutans and Lactobacillus bacteria, and the assessment of gingival indices in orthodontic patients.
Methods
In this double-blind clinical trial, 60 fixed orthodontic patients were randomly assigned to three groups: Protact mouthwash, 0.12 % chlorhexidine (CHX), and placebo (Normal saline; NS). Patients were given the necessary training on correct brushing, use of mouthwash, and dental floss. Gingival indices, including papillary bleeding index (PBI) and modified gingival index (MGI), as well as bacterial colony counts of Streptococcus mutans and Lactobacillus, were assessed at baseline and 21 days after mouthwash application. Data were analyzed using SPSS version 20.
Results
After 21 days, the colony counts of both Streptococcus mutans and Lactobacillus decreased significantly in the CHX and Protact mouthwash groups, whereas an increase in colony counts was observed in the NS group, which showed an 11 % increase. Moreover, reductions in both MGI and PBI were significantly greater in the CHX and Protact groups compared to the NS group (P < 0.05).
Conclusion
This study demonstrated that Protact mouthwash containing Zataria multiflora extract effectively reduces the colony counts of Streptococcus mutans and Lactobacillus and improves the gingival indices in patients receiving fixed orthodontic treatment.
目的：固定正畸治疗是牙龈炎和牙周问题的高危人群；因此，定期消毒正畸器具及齿圈对保持口腔健康是必要的。由于常用化学漱口水易引起敏感性和黏膜病变，本研究旨在评价含多连扎扎草提取物（ZM）的Protact漱口水对变形链球菌和乳杆菌的作用，以及正畸患者牙龈指标的评估。方法在本双盲临床试验中，60例固定正畸患者随机分为三组：Protact漱口水、0.12 %氯己定（CHX）和安慰剂（生理盐水；NS）。患者接受了正确刷牙、使用漱口水和牙线的必要培训。在基线和使用漱口水后21天评估牙龈指数，包括乳头状出血指数（PBI）和改良牙龈指数（MGI），以及变形链球菌和乳酸杆菌的菌落计数。数据分析采用SPSS version 20。结果21 d后，CHX和Protact漱口水组的变形链球菌和乳酸菌菌落计数均显著下降，而NS组的菌落计数增加，增加了11. %。此外，与NS组相比，CHX组和Protact组MGI和PBI的降低明显更大（P <； 0.05）。结论复方扎扎草提取物Protact漱口水可有效降低变形链球菌和乳酸杆菌菌落计数，改善固定正畸治疗患者的牙龈指标。
{"title":"Efficacy of Zataria multiflora on oral bacterial and periodontal indices in fixed orthodontic patients: A double-blind, randomized, controlled, clinical trial","authors":"Maryam Fatemipour , Zeinab Naghshvarian Jahromi , Fatemeh Amin , Ebrahim Rezazadeh Zarandi , Bahareh Fatemipour , Seyed Mehdi Vahedi , Amir Hossein Fatehi Marj","doi":"10.1016/j.ajoms.2025.09.005","DOIUrl":"10.1016/j.ajoms.2025.09.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients undergoing fixed orthodontic treatment are at high risk of gingivitis and periodontal problems; therefore, regular disinfection of orthodontic appliances and rims is necessary to maintain oral health. As common chemical mouthwashes often lead to sensitivity and mucosal lesions, the present study aimed to evaluate the effect of Protact mouthwash containing the extract of Zataria multiflora (ZM) on <em>Streptococcus mutans</em> and <em>Lactobacillus</em> bacteria, and the assessment of gingival indices in orthodontic patients.</div></div><div><h3>Methods</h3><div>In this double-blind clinical trial, 60 fixed orthodontic patients were randomly assigned to three groups: Protact mouthwash, 0.12 % chlorhexidine (CHX), and placebo (Normal saline; NS). Patients were given the necessary training on correct brushing, use of mouthwash, and dental floss. Gingival indices, including papillary bleeding index (PBI) and modified gingival index (MGI), as well as bacterial colony counts of <em>Streptococcus mutans</em> and <em>Lactobacillus</em>, were assessed at baseline and 21 days after mouthwash application. Data were analyzed using SPSS version 20.</div></div><div><h3>Results</h3><div>After 21 days, the colony counts of both <em>Streptococcus mutans</em> and <em>Lactobacillus</em> decreased significantly in the CHX and Protact mouthwash groups, whereas an increase in colony counts was observed in the NS group, which showed an 11 % increase. Moreover, reductions in both MGI and PBI were significantly greater in the CHX and Protact groups compared to the NS group (P < 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that Protact mouthwash containing Zataria multiflora extract effectively reduces the colony counts of <em>Streptococcus mutans</em> and <em>Lactobacillus</em> and improves the gingival indices in patients receiving fixed orthodontic treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 286-290"},"PeriodicalIF":0.4,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maxillary anterior segmental distraction osteogenesis (MASDO) is a surgical technique that enables large maxillary anterior movement without worsening nasopharyngeal function and is an effective orthodontic treatment for patients with CLP; nevertheless, there is a risk of root damage to the teeth when the maxilla is divided. In this study, we compared the safety and efficacy of osteotomy using two types of surgical guides in MASDO with those in previous cases in which surgical guides were not used.
Methods
We compared cases with and without surgical guides to determine whether there was any damage to the roots or exposure of the roots. Furthermore, we compared the operating time and amount of bleeding for osteotomy using two types of surgical guide at MASDO (Surgical guide with the tooth morphology of the adjacent teeth and slit-type surgical guide).
Results
In cases where surgical guides were used, there were no cases of root damage, and use of slit-type surgical guides tended to reduce operating time and intraoperative bleeding volume.
Conclusions
MASDO and surgical guides improve safety by reducing apical damage, and slit-type surgical guides improve bleeding and operating time in CLP patients, increasing efficiency and optimizing results.
{"title":"Comparative assessment of 3D-printed patient-specific surgical guides for maxillary anterior segmental distraction osteogenesis (MASDO): Avoiding the risk of tooth damage","authors":"Soju Seki, Yuko Shintaku, Kazuma Harada, Yukako Shimaoka, Koichi Hayashi, Shiho Mima, Akira Nishiura, Takuji Yasuda, Emiko Tanaka Isomura, Susumu Tanaka, Yusuke Yokota","doi":"10.1016/j.ajoms.2025.09.001","DOIUrl":"10.1016/j.ajoms.2025.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>Maxillary anterior segmental distraction osteogenesis (MASDO) is a surgical technique that enables large maxillary anterior movement without worsening nasopharyngeal function and is an effective orthodontic treatment for patients with CLP; nevertheless, there is a risk of root damage to the teeth when the maxilla is divided. In this study, we compared the safety and efficacy of osteotomy using two types of surgical guides in MASDO with those in previous cases in which surgical guides were not used.</div></div><div><h3>Methods</h3><div>We compared cases with and without surgical guides to determine whether there was any damage to the roots or exposure of the roots. Furthermore, we compared the operating time and amount of bleeding for osteotomy using two types of surgical guide at MASDO (Surgical guide with the tooth morphology of the adjacent teeth and slit-type surgical guide).</div></div><div><h3>Results</h3><div>In cases where surgical guides were used, there were no cases of root damage, and use of slit-type surgical guides tended to reduce operating time and intraoperative bleeding volume.</div></div><div><h3>Conclusions</h3><div>MASDO and surgical guides improve safety by reducing apical damage, and slit-type surgical guides improve bleeding and operating time in CLP patients, increasing efficiency and optimizing results.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 279-285"},"PeriodicalIF":0.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The accessory parotid gland is an anatomical variation of the salivary gland system, is typically unilateral and located anterior to the main parotid gland, connected to it via an independent ductal system. It may be misidentified as a buccal mass and has been implicated in the development of parotid tumors. Salivary duct cysts, also known as mucous retention cysts, are non-neoplastic cystic lesions that account for approximately 2–5 % of all salivary gland pathologies. Although generally benign, rare cases of malignant transformation have been reported. To the best of our knowledge, this is the first documented case of a salivary duct cysts arising from the accessory parotid gland. The patient was a 63-year-old man who presented with left buccal pain that had persisted for six months, followed by a rapid swelling in the same region. Based on imaging and fine-needle aspiration findings, a benign tumor or cystic lesion arising from the accessory parotid gland was suspected, and surgical excision was performed. Histopathological examination confirmed the diagnosis of a salivary duct cyst arising from the accessory parotid gland. Although rare, both lesion of accessory parotid gland and salivary duct cyst have been associated with malignant transformation. Therefore, careful diagnostic evaluation and treatment planning with malignancy in mind are essential.
{"title":"A case of salivary duct cyst arising from the accessory parotid gland","authors":"Yudai Shimizu , Taiki Suzuki , Yoshihiro Ohashi , Reo Aoki , Kenichi Kumagai , Takanori Eguchi , Yoshiki Hamada","doi":"10.1016/j.ajoms.2025.08.009","DOIUrl":"10.1016/j.ajoms.2025.08.009","url":null,"abstract":"<div><div>The accessory parotid gland is an anatomical variation of the salivary gland system, is typically unilateral and located anterior to the main parotid gland, connected to it via an independent ductal system. It may be misidentified as a buccal mass and has been implicated in the development of parotid tumors. Salivary duct cysts, also known as mucous retention cysts, are non-neoplastic cystic lesions that account for approximately 2–5 % of all salivary gland pathologies. Although generally benign, rare cases of malignant transformation have been reported. To the best of our knowledge, this is the first documented case of a salivary duct cysts arising from the accessory parotid gland. The patient was a 63-year-old man who presented with left buccal pain that had persisted for six months, followed by a rapid swelling in the same region. Based on imaging and fine-needle aspiration findings, a benign tumor or cystic lesion arising from the accessory parotid gland was suspected, and surgical excision was performed. Histopathological examination confirmed the diagnosis of a salivary duct cyst arising from the accessory parotid gland. Although rare, both lesion of accessory parotid gland and salivary duct cyst have been associated with malignant transformation. Therefore, careful diagnostic evaluation and treatment planning with malignancy in mind are essential.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 312-316"},"PeriodicalIF":0.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study evaluated changes in salivary alpha-amylase activity (sAA) before and after orotracheal intubation (TI) and precordial skin incision (SI) to investigate whether sAA was increased by noxious stimuli while under general anesthesia.
Methods
sAA was measured before and after TI (study A: randomized double-blind test) and SI (study B; single-arm observational test) in 50 and 30 patients, respectively. Study A patients were divided into 2 groups of 25 each according to administration of 1.0 (LF group) or 2.0 µg/kg of fentanyl (HF group) during anesthesia induction. sAA was measured at four points, with study A measurements performed before anesthesia induction, immediately before TI, and at 3 and 6 min after TI, while study B measurements were performed before anesthesia induction, immediately before SI, and at 3 and 6 min after SI, respectively.
Results
sAA significantly increased at 3 min after TI, and at 3 and 6 min after SI compared to before the procedure (P < 0.01). In study A, the observed sAA levels at 3 and 6 min after TI in the HF group were significantly lower than those observed in the LF group (P < 0.01).
Conclusions
sAA increased after TI and SI. sAA measurements might be an ancillary indicator for sympathetic tone associated with noxious stimuli under general anesthesia.
目的观察全身麻醉下经气管插管（TI）和心前皮肤切开（SI）前后唾液α -淀粉酶活性（sAA）的变化，探讨有害刺激是否会使sAA升高。方法分别测定50例和30例患者在TI（研究A：随机双盲试验）和SI（研究B：单臂观察试验）前后的ssaa。研究A根据麻醉诱导时芬太尼剂量1.0 （LF组）或2.0 µg/kg （HF组）分为2组，每组25例。在四个点测量sAA，研究A在麻醉诱导前、TI前、TI后3和6 min测量sAA，而研究B分别在麻醉诱导前、SI前和SI后3和6 min测量sAA。结果与术前相比，TI术后3 min、SI术后3、6 min saa明显升高（P <； 0.01）。研究A中，HF组TI后3、6 min sAA水平显著低于LF组（P <； 0.01）。结论经TI和SI治疗后saa升高。在全身麻醉下，sAA测量可能是与有害刺激相关的交感神经张力的辅助指标。
{"title":"Salivary alpha-amylase activity is increased by noxious stimuli under general anesthesia","authors":"Noriya Hirose , Miki Matsui , Masumi Itagaki , Nao Shimizu , Mizuki Mizoguchi , Hisataka Kitano , Emily Chang , Kanako Yamagata , Takahiro Suzuki","doi":"10.1016/j.ajoms.2025.09.003","DOIUrl":"10.1016/j.ajoms.2025.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated changes in salivary alpha-amylase activity (sAA) before and after orotracheal intubation (TI) and precordial skin incision (SI) to investigate whether sAA was increased by noxious stimuli while under general anesthesia.</div></div><div><h3>Methods</h3><div>sAA was measured before and after TI (study A: randomized double-blind test) and SI (study B; single-arm observational test) in 50 and 30 patients, respectively. Study A patients were divided into 2 groups of 25 each according to administration of 1.0 (LF group) or 2.0 µg/kg of fentanyl (HF group) during anesthesia induction. sAA was measured at four points, with study A measurements performed before anesthesia induction, immediately before TI, and at 3 and 6 min after TI, while study B measurements were performed before anesthesia induction, immediately before SI, and at 3 and 6 min after SI, respectively.</div></div><div><h3>Results</h3><div>sAA significantly increased at 3 min after TI, and at 3 and 6 min after SI compared to before the procedure (P < 0.01). In study A, the observed sAA levels at 3 and 6 min after TI in the HF group were significantly lower than those observed in the LF group (P < 0.01).</div></div><div><h3>Conclusions</h3><div>sAA increased after TI and SI. sAA measurements might be an ancillary indicator for sympathetic tone associated with noxious stimuli under general anesthesia.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 201-208"},"PeriodicalIF":0.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A surgical ciliated cyst (SC cyst) is a non-odontogenic lesion that can develop in the maxilla when respiratory (ciliated) epithelium from the maxillary sinus or nasal cavity becomes entrapped in bone during surgery. Although SC cysts most often develop following procedures that breach the maxillary sinus mucosa, they may also occur, though rarely, at an alveolar bone graft site in patients with an alveolar cleft. Reported here is a case of a large SC cyst that formed at an alveolar bone graft site and was then successfully managed with enucleation, particulate cancellous bone and marrow (PCBM) grafting under a custom titanium mesh, and implant placement in the same area, resulting in excellent occlusion. A 31-year-old male was presented with gingival swelling in the anterior maxilla. The patient had undergone PCBM grafting at the age of nine years for a right-side cleft lip and alveolus. CT scanning revealed a sizable cystic lesion (45 × 32 × 28 mm) in the anterior maxilla. A cystectomy including nucleation and PCBM grafting with a titanium mesh was performed, followed by implant placement approximately two years later. No evidence of cyst recurrence or implant failure has been noted more than ten years following the operation.
{"title":"Case of adult unilateral cleft lip and alveolus treated with occlusal reconstruction at alveolar bone graft site following removal of giant surgical ciliated cyst","authors":"Kazuhiro Imoto , Shinnosuke Nogami , Nyungkwang Kwon , Hiromitsu Morishima , Keiko Matsui , Hiroyuki Kumamoto , Kensuke Yamauchi","doi":"10.1016/j.ajoms.2025.09.004","DOIUrl":"10.1016/j.ajoms.2025.09.004","url":null,"abstract":"<div><div>A surgical ciliated cyst (SC cyst) is a non-odontogenic lesion that can develop in the maxilla when respiratory (ciliated) epithelium from the maxillary sinus or nasal cavity becomes entrapped in bone during surgery. Although SC cysts most often develop following procedures that breach the maxillary sinus mucosa, they may also occur, though rarely, at an alveolar bone graft site in patients with an alveolar cleft. Reported here is a case of a large SC cyst that formed at an alveolar bone graft site and was then successfully managed with enucleation, particulate cancellous bone and marrow (PCBM) grafting under a custom titanium mesh, and implant placement in the same area, resulting in excellent occlusion. A 31-year-old male was presented with gingival swelling in the anterior maxilla. The patient had undergone PCBM grafting at the age of nine years for a right-side cleft lip and alveolus. CT scanning revealed a sizable cystic lesion (45 × 32 × 28 mm) in the anterior maxilla. A cystectomy including nucleation and PCBM grafting with a titanium mesh was performed, followed by implant placement approximately two years later. No evidence of cyst recurrence or implant failure has been noted more than ten years following the operation.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 255-261"},"PeriodicalIF":0.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-31DOI: 10.1016/j.ajoms.2025.08.010
Jun-ichi Kanayama , Ken-ichiro Sakata , Yusuke Nakamura , Aya Yanagawa-Matsuda , Tougo Tanabe , Yasushi Kato , Jun Sato , Yoshimasa Kitagawa
Plasmacytoma is a malignant tumor characterized by neoplastic proliferation of plasma cells. Its subtypes include multiple myeloma, solitary plasmacytoma, and extramedullary plasmacytoma. Plasmacytoma originating from the maxillary bone is extremely rare. We herein present a case of a 60-year-old male patient with solitary plasmacytoma in this anatomic structure. The patient, who had normal general condition, was admitted to our department with complaints of nasal bleeding during mastication. Oral and nasal examination showed redness and swelling of the left upper gingiva along with elevation of the bottom of the left nasal cavity. Panoramic X-ray and computed tomography revealed unilocular bone resorption around the impacted teeth, with signs of lesion infiltration into the nasal cavity. After the clinical diagnosis of benign maxillary tumor, our team, including an otorhinolaryngologist, resected the lesion from the left maxillary bone and nasal cavity. A pathological examination of the two excision sites also showed plasma cell neoplasms. As no abnormalities were detected in other bone parts following bone marrow aspiration as well as blood and urine tests, the patient was diagnosed with solitary plasmacytoma of the maxillary bone. We performed additional local radiotherapy with a total of 50 Gy of absorbed ionizing radiation dose. The patient has been undergoing a follow-up observation for more than 3 years, with no signs of local recurrence or progression to multiple myeloma.
{"title":"Plasmacytoma of the Maxilla presenting with nosebleeds: A case report","authors":"Jun-ichi Kanayama , Ken-ichiro Sakata , Yusuke Nakamura , Aya Yanagawa-Matsuda , Tougo Tanabe , Yasushi Kato , Jun Sato , Yoshimasa Kitagawa","doi":"10.1016/j.ajoms.2025.08.010","DOIUrl":"10.1016/j.ajoms.2025.08.010","url":null,"abstract":"<div><div>Plasmacytoma is a malignant tumor characterized by neoplastic proliferation of plasma cells. Its subtypes include multiple myeloma, solitary plasmacytoma, and extramedullary plasmacytoma. Plasmacytoma originating from the maxillary bone is extremely rare. We herein present a case of a 60-year-old male patient with solitary plasmacytoma in this anatomic structure. The patient, who had normal general condition, was admitted to our department with complaints of nasal bleeding during mastication. Oral and nasal examination showed redness and swelling of the left upper gingiva along with elevation of the bottom of the left nasal cavity. Panoramic X-ray and computed tomography revealed unilocular bone resorption around the impacted teeth, with signs of lesion infiltration into the nasal cavity. After the clinical diagnosis of benign maxillary tumor, our team, including an otorhinolaryngologist, resected the lesion from the left maxillary bone and nasal cavity. A pathological examination of the two excision sites also showed plasma cell neoplasms. As no abnormalities were detected in other bone parts following bone marrow aspiration as well as blood and urine tests, the patient was diagnosed with solitary plasmacytoma of the maxillary bone. We performed additional local radiotherapy with a total of 50 Gy of absorbed ionizing radiation dose. The patient has been undergoing a follow-up observation for more than 3 years, with no signs of local recurrence or progression to multiple myeloma.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 317-323"},"PeriodicalIF":0.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intraosseous arteriovenous malformations of the jaw (J-AVM) are rare, high-flow vascular malformations that can cause life-threatening bleeding, particularly during dental procedures. J-AVM are predominantly diagnosed in younger patients, J-AVM are predominantly diagnosed in younger patients, while onset in the elderly is exceptionally rare. A 76-year-old man who presented with a rapidly enlarging intraosseous AVM of the mandible requiring emergency intervention. Emergency embolization followed by radical partial mandibulectomy was performed. Histopathological examination revealed hemorrhagic necrosis and aneurysmal changes without endothelial proliferation, leading to a final diagnosis of intraosseous AVM according to the International Society for the Study of Vascular Anomalies (ISSVA) classification. This case highlights the unique clinical challenges of diagnosing and managing J-AVM in elderly patients, including age-related anatomical changes, comorbidities, and the potential for atypical clinical and radiographic presentations. We conducted a literature review but identified only a few relevant studies, making it difficult to determine appropriate treatment strategies for J-AVM in elderly patients. However, given the multidisciplinary nature of J-AVM management, there is a clear need to harmonize diagnostic and treatment criteria. Consideration of elderly-onset J-AVM cases should also be incorporated into future clinical frameworks to ensure optimal patient outcomes.
{"title":"Treatment strategy for intraosseous arteriovenous malformations of the jaw in elderly patients: A case report and literature review","authors":"Chieko Masuda , Taiki Suzuki , Yoshihiro Ohashi , Yudai Shimizu , Kenichi Kumagai , Takanori Eguchi , Yoshiki Hamada , Akihisa Horie","doi":"10.1016/j.ajoms.2025.08.013","DOIUrl":"10.1016/j.ajoms.2025.08.013","url":null,"abstract":"<div><div>Intraosseous arteriovenous malformations of the jaw (J-AVM) are rare, high-flow vascular malformations that can cause life-threatening bleeding, particularly during dental procedures. J-AVM are predominantly diagnosed in younger patients, J-AVM are predominantly diagnosed in younger patients, while onset in the elderly is exceptionally rare. A 76-year-old man who presented with a rapidly enlarging intraosseous AVM of the mandible requiring emergency intervention. Emergency embolization followed by radical partial mandibulectomy was performed. Histopathological examination revealed hemorrhagic necrosis and aneurysmal changes without endothelial proliferation, leading to a final diagnosis of intraosseous AVM according to the International Society for the Study of Vascular Anomalies (ISSVA) classification. This case highlights the unique clinical challenges of diagnosing and managing J-AVM in elderly patients, including age-related anatomical changes, comorbidities, and the potential for atypical clinical and radiographic presentations. We conducted a literature review but identified only a few relevant studies, making it difficult to determine appropriate treatment strategies for J-AVM in elderly patients. However, given the multidisciplinary nature of J-AVM management, there is a clear need to harmonize diagnostic and treatment criteria. Consideration of elderly-onset J-AVM cases should also be incorporated into future clinical frameworks to ensure optimal patient outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 247-254"},"PeriodicalIF":0.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号