Granulomatous lesions in the head and neck include Langerhans cell histiocytosis (LCH) and Erdheim–Chester disease (ECD). ECD is a rare non-LCH characterised by histiocytic infiltration of multiple organ systems. In the head and neck region, there are some reports of its occurrence in the bony skeleton; however, it is extremely rare in soft tissues. Herein, we report a case of tongue granuloma requiring the differentiation of LCH and ECD. A 64-year-old man was referred to our hospital for swelling of the tongue and oral floor. We performed a biopsy and diagnosed ECD pathologically. However, as no bone lesions were identified in other parts of the body, a diagnosis of tongue granuloma was made. Following systemic administration of corticosteroids, the swelling of the tongue and oral floor completely disappeared. Steroids were gradually decreased, and there were no signs of recurrence of the disease. This case underscores the importance of considering ECD in the differential diagnosis of granulomatous lesions in the head and neck, even in soft tissues, and highlights the efficacy of corticosteroid therapy in managing associated symptoms.
{"title":"A case of tongue granuloma requiring differentiation of Langerhans cell histiocytosis and Erdheim–Chester disease","authors":"Katsuhisa Sekido , Takashi Kawane , Yoshinobu Maeda , Danki Takatsuka , Koji Takii , Ryo Ouchi","doi":"10.1016/j.ajoms.2024.08.008","DOIUrl":"10.1016/j.ajoms.2024.08.008","url":null,"abstract":"<div><div>Granulomatous lesions in the head and neck include Langerhans cell histiocytosis (LCH) and Erdheim–Chester disease (ECD). ECD is a rare non-LCH characterised by histiocytic infiltration of multiple organ systems. In the head and neck region, there are some reports of its occurrence in the bony skeleton; however, it is extremely rare in soft tissues. Herein, we report a case of tongue granuloma requiring the differentiation of LCH and ECD. A 64-year-old man was referred to our hospital for swelling of the tongue and oral floor. We performed a biopsy and diagnosed ECD pathologically. However, as no bone lesions were identified in other parts of the body, a diagnosis of tongue granuloma was made. Following systemic administration of corticosteroids, the swelling of the tongue and oral floor completely disappeared. Steroids were gradually decreased, and there were no signs of recurrence of the disease. This case underscores the importance of considering ECD in the differential diagnosis of granulomatous lesions in the head and neck, even in soft tissues, and highlights the efficacy of corticosteroid therapy in managing associated symptoms.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 385-390"},"PeriodicalIF":0.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methotrexate (MTX)-associated lymphoproliferative diseases (LPD) have been reported to occur in the oral cavity. However, there are no reports of LPD in the oral cavity caused by anti-TNF-α inhibitors. A 37-year-old man was initially treated for diffuse large B-cell lymphoma (DLBCL) after prolonged treatment with infliximab (IFX) and azathioprine (AZA) for Crohn’s disease (CD). The patient was aware of an abnormal right upper molar and was transferred to our hospital. DLBCL was diagnosed based on biopsy specimens of the mass in the right upper molar region. Six courses of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone were administered. After chemotherapy, the lymphoma showed complete remission for two years.
{"title":"A case of lymphoproliferative disease of the palate while receiving infliximab and azathioprine for Crohn's disease","authors":"Nanako Ito , Tomoaki Hamana , Hisako Furusho , Natsuki Eboshida , Yasuyuki Asada , Fumitaka Obayashi , Mirai Higaki , Atsuko Hamada , Sachiko Yamasaki , Toshinori Ando , Koichi Koizumi , Souichi Yanamoto","doi":"10.1016/j.ajoms.2024.08.010","DOIUrl":"10.1016/j.ajoms.2024.08.010","url":null,"abstract":"<div><div>Methotrexate (MTX)-associated lymphoproliferative diseases (LPD) have been reported to occur in the oral cavity. However, there are no reports of LPD in the oral cavity caused by anti-TNF-α inhibitors. A 37-year-old man was initially treated for diffuse large B-cell lymphoma (DLBCL) after prolonged treatment with infliximab (IFX) and azathioprine (AZA) for Crohn’s disease (CD). The patient was aware of an abnormal right upper molar and was transferred to our hospital. DLBCL was diagnosed based on biopsy specimens of the mass in the right upper molar region. Six courses of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone were administered. After chemotherapy, the lymphoma showed complete remission for two years.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 365-370"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1016/j.ajoms.2024.08.013
Arzum Yilmaz , Sedat Çeti̇ner , Ilgin Ari
Objective
Mandibular bone defects are a common problem and difficult to manage. A defected area mostly left to heal spontaneously. It doesn’t have a definite protocol in the literature, when the area will be left to heal spontaneously or when supported with materials such as plates, screws, grafts, especially in intermediate-sized defects. In this study, it was aimed to determine by examining the areas where the stresses due to chewing forces are concentrated on the mandible bone and the risk of fracture in intermediate size unicortical and bicortical defects.
Material and Methods
The all defect models which was the residual bone heights were 6, 8, 10 mm in mandibular corpus region were created. Two different loading scenarios were applied anterior and defected premolar side. Von Mises, Pmax and Pmin stresses in models were evaluated by three-dimensional finite element analysis method.
Results
The study found higher stress accumulation on the buccal anterior side of defects in both unicortical and bicortical models, with the most stress concentrated at the buccal corners. Under Loading 1, bicortical defects with 10 mm residual bone height showed slightly higher stress accumulations than unicortical defects, while bicortical defects with 8 and 6 mm residual bone height exhibited significantly higher stress values. Under Loading 2, stress accumulations in bicortical defects were higher than in unicortical defects, with bicortical defects at 6 mm residual bone height showing almost double the stress values. Pmax stress values were higher in bicortical defects under both loadings, especially when the residual bone height decreased. Pmin stress values were comparable in unicortical defects but were higher in bicortical defects, particularly at 6 mm residual bone height, under both loading conditions.
Conclusion
This study was presented that mandibular resistance decreases significantly when residual bone height is less than 10 mm for bicortical defects and less than 8 mm at unicortical defects. In these conditions it may need supported with materials to prevent fractures. However, in vivo and in vitro studies are necessary for definitive conclusions.
{"title":"The evaluation of pathologic fracture risk and residual bone height in unicortical and bicortical mandibular corpus defects: A 3D finite analysis","authors":"Arzum Yilmaz , Sedat Çeti̇ner , Ilgin Ari","doi":"10.1016/j.ajoms.2024.08.013","DOIUrl":"10.1016/j.ajoms.2024.08.013","url":null,"abstract":"<div><h3>Objective</h3><div>Mandibular bone defects are a common problem and difficult to manage. A defected area mostly left to heal spontaneously. It doesn’t have a definite protocol in the literature, when the area will be left to heal spontaneously or when supported with materials such as plates, screws, grafts, especially in intermediate-sized defects. In this study, it was aimed to determine by examining the areas where the stresses due to chewing forces are concentrated on the mandible bone and the risk of fracture in intermediate size unicortical and bicortical defects.</div></div><div><h3>Material and Methods</h3><div>The all defect models which was the residual bone heights were 6, 8, 10 mm in mandibular corpus region were created. Two different loading scenarios were applied anterior and defected premolar side. Von Mises, Pmax and Pmin stresses in models were evaluated by three-dimensional finite element analysis method.</div></div><div><h3>Results</h3><div>The study found higher stress accumulation on the buccal anterior side of defects in both unicortical and bicortical models, with the most stress concentrated at the buccal corners. Under Loading 1, bicortical defects with 10 mm residual bone height showed slightly higher stress accumulations than unicortical defects, while bicortical defects with 8 and 6 mm residual bone height exhibited significantly higher stress values. Under Loading 2, stress accumulations in bicortical defects were higher than in unicortical defects, with bicortical defects at 6 mm residual bone height showing almost double the stress values. Pmax stress values were higher in bicortical defects under both loadings, especially when the residual bone height decreased. Pmin stress values were comparable in unicortical defects but were higher in bicortical defects, particularly at 6 mm residual bone height, under both loading conditions.</div></div><div><h3>Conclusion</h3><div>This study was presented that mandibular resistance decreases significantly when residual bone height is less than 10 mm for bicortical defects and less than 8 mm at unicortical defects. In these conditions it may need supported with materials to prevent fractures. However, in vivo and in vitro studies are necessary for definitive conclusions.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 84-91"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate periodontal tissue regenerative potential of octacalcium phosphate (OCP) and collagen composite (OCPcol), recognized as excellent bone-regenerative materials, in artificial bone defect models using beagle dogs. This study specifically assessed the efficacy of OCPcol in periodontal soft-tissue regeneration.
Methods
OCPcol was implanted in bone defects adjacent to the roots of the left mandibular third and fourth premolars in six beagle dogs (OCP group), while five dogs did not receive OCPcol (control group). The dogs were observed for 3 months. The specimens were evaluated radiologically and histologically.
Results
Microcomputed tomography revealed bone regeneration originating from the lateral cortical bone surface adjacent to the created defect. The superficial layer of the regenerated bone was cortical bone-like and continuous with the upper and lower alveolar bone. The bone was regenerated by maintaining a continuous void in the periodontal ligament space above and below the dentinal defect. Dental defects of roots were not regenerated. The control group did not exhibit sufficient bone regeneration. Histologically, in the OCP group, formation of new cementum was observed on the outer surface of the root dentin, with connective tissue attachment and an oblique-running periodontal ligament in the space between the new bone and dentin. However, the dentinal defects were not regenerated．
Conclusions
Alveolar bone and periodontal ligament regenerated when OCPcol was implanted into a bone and dentinal defect created around a natural tooth root. These results suggest that OCPcol effectively regenerates periodontal tissue, without ankylosis.
{"title":"Investigation of periodontal tissue regeneration using octacalcium phosphate and collagen composite","authors":"Keiko Matsui , Shinji Kamakura , Atsumu Kouketsu , Yushi Ezoe , Kei-ichiro Miura , Kensuke Yamauchi","doi":"10.1016/j.ajoms.2024.08.009","DOIUrl":"10.1016/j.ajoms.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate periodontal tissue regenerative potential of octacalcium phosphate (OCP) and collagen composite (OCPcol), recognized as excellent bone-regenerative materials, in artificial bone defect models using beagle dogs. This study specifically assessed the efficacy of OCPcol in periodontal soft-tissue regeneration.</div></div><div><h3>Methods</h3><div>OCPcol was implanted in bone defects adjacent to the roots of the left mandibular third and fourth premolars in six beagle dogs (OCP group), while five dogs did not receive OCPcol (control group). The dogs were observed for 3 months. The specimens were evaluated radiologically and histologically.</div></div><div><h3>Results</h3><div>Microcomputed tomography revealed bone regeneration originating from the lateral cortical bone surface adjacent to the created defect. The superficial layer of the regenerated bone was cortical bone-like and continuous with the upper and lower alveolar bone. The bone was regenerated by maintaining a continuous void in the periodontal ligament space above and below the dentinal defect. Dental defects of roots were not regenerated. The control group did not exhibit sufficient bone regeneration. Histologically, in the OCP group, formation of new cementum was observed on the outer surface of the root dentin, with connective tissue attachment and an oblique-running periodontal ligament in the space between the new bone and dentin. However, the dentinal defects were not regenerated．</div></div><div><h3>Conclusions</h3><div>Alveolar bone and periodontal ligament regenerated when OCPcol was implanted into a bone and dentinal defect created around a natural tooth root. These results suggest that OCPcol effectively regenerates periodontal tissue, without ankylosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 76-83"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitrogen-containing bisphosphonates (NBPs) and denosumab are widely-used anti-bone-resorptive agents. However, osteonecrosis of the jaw (ONJ) is a known side effect with each of them (called BRONJ or DRONJ, respectively). BRONJ and DRONJ are intractable, and no sound/solid treatments have been established. Some reports note that denosumab carries a greater risk of ONJ than NBPs, and that they mutually augment the risk. Our previous animal and in vitro studies led us to suppose that etidronate (a bisphosphonate not containing nitrogen) may be effective against BRONJ, and we reported that etidronate ameliorated BRONJ in all 13 of the patients we tested. Here, we add a case in which etidronate healed stage 3 ONJ caused by alendronate (an NBP) followed by denosumab. We first treated her with minocycline (a bacteriostatic antibiotic) and then etidronate. Pain and drainage disappeared with minocycline. Within 3 weeks after the start of etidronate, bone exposure was markedly reduced and it had disappeared within 6 months, being followed by osteogenesis in the injured area and fracture-line disappearance. These results suggest that (i) in the present patient, the major cause of ONJ might have been alendronate, with denosumab possibly promoting its progress, (ii) etidronate is effective against BRONJ caused not only by NBPs, but also by NBPs + denosumab, and (iii) minocycline is suitable as a combination drug with etidronate, because in addition to its bacteriostatic effect, minocycline has various effects helping to ameliorate ONJ, including analgesic, anti-inflammatory, and bone-forming effects together with its high affinity for bone.
{"title":"Osteonecrosis of the jaw in a patient treated with alendronate and then denosumab: A case of dramatic amelioration by minocycline and then etidronate","authors":"Takefumi Oizumi , Kazuhiro Imoto , Kanan Bando , Yukinori Tanaka , Hiromi Funayama , Kensuke Yamauchi , Hiroyuki Kumamoto , Tetsu Takahashi , Yasuo Endo","doi":"10.1016/j.ajoms.2024.07.012","DOIUrl":"10.1016/j.ajoms.2024.07.012","url":null,"abstract":"<div><div>Nitrogen-containing bisphosphonates (NBPs) and denosumab are widely-used anti-bone-resorptive agents. However, osteonecrosis of the jaw (ONJ) is a known side effect with each of them (called BRONJ or DRONJ, respectively). BRONJ and DRONJ are intractable, and no sound/solid treatments have been established. Some reports note that denosumab carries a greater risk of ONJ than NBPs, and that they mutually augment the risk. Our previous animal and in vitro studies led us to suppose that etidronate (a bisphosphonate not containing nitrogen) may be effective against BRONJ, and we reported that etidronate ameliorated BRONJ in all 13 of the patients we tested. Here, we add a case in which etidronate healed stage 3 ONJ caused by alendronate (an NBP) followed by denosumab. We first treated her with minocycline (a bacteriostatic antibiotic) and then etidronate. Pain and drainage disappeared with minocycline. Within 3 weeks after the start of etidronate, bone exposure was markedly reduced and it had disappeared within 6 months, being followed by osteogenesis in the injured area and fracture-line disappearance. These results suggest that (i) in the present patient, the major cause of ONJ might have been alendronate, with denosumab possibly promoting its progress, (ii) etidronate is effective against BRONJ caused not only by NBPs, but also by NBPs + denosumab, and (iii) minocycline is suitable as a combination drug with etidronate, because in addition to its bacteriostatic effect, minocycline has various effects helping to ameliorate ONJ, including analgesic, anti-inflammatory, and bone-forming effects together with its high affinity for bone.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 348-355"},"PeriodicalIF":0.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To differentiate between metastatic neck nodes and non-metastatic neck nodes in oral maxillary gingival squamous cell carcinoma, textural analysis of these lymph nodes in ultrasound images was performed in this study.
Methods
Twenty five metastatic neck nodes and 28 non-metastatic neck nodes were enrolled in this study. Seventy eight texture characteristics were retrieved from the US images using the LIFEx software.
The Mann Whitney U test was measurably utilized to survey on the off chance that there was a measurably noteworthy distinction within the textural characteristics between metastatic neck nodes and non-metastatic neck nodes. The capacity of the surface highlights to recognize between metastatic neck nodes and non-metastatic neck nodes was illustrated utilizing the Receiver Operating Characteristic analysis curves (ROC). Youden's J statistic was used to determine the cut-off positions in each ROC curve that maximized sensitivity and specificity.
Results
Zone size non uniformity (ZSNU) highlight appeared the foremost noteworthy contrast between these nodes (p < 0.001).
Strength had Area Under the Curve (AUC) of 0.811, specificity of 0.821 and sensitivity of 0.8, when measured at the cutoff value of 896.344.
Conclusions
Our results come about uncovered that quality highlight may be the finest surface highlight to distinguish from non-metastatic neck nodes and to anticipate metastatic neck nodes in oral maxillary gingival squamous cell carcinoma.
为了区分口腔上颌牙龈鳞状细胞癌的转移性颈部淋巴结和非转移性颈部淋巴结，本研究对这些淋巴结的超声图像进行了纹理分析。使用 LIFEx 软件从超声图像中提取了 78 个纹理特征。采用 Mann Whitney U 检验来调查转移性颈部结节和非转移性颈部结节的纹理特征是否存在显著差异。利用接收者操作特性分析曲线（ROC）说明了表面亮点识别转移性颈部结节和非转移性颈部结节的能力。结果Zone size non uniformity (ZSNU) 高亮显示出这些结节之间最显著的对比（p < 0.001），强度曲线下面积（AUC）为 0.811，特异性为 0.结论我们的研究结果发现，质量高亮度可能是区分非转移性颈部结节和预测口腔上颌龈鳞癌转移性颈部结节的最佳表面高亮度。
{"title":"Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma","authors":"Yusuke Kawashima , Aya Hagimoto , Hiroshi Abe , Masaaki Miyakoshi , Yoshihiro Kawabata , Hiroko Indo , Tatsurou Tanaka","doi":"10.1016/j.ajoms.2024.07.013","DOIUrl":"10.1016/j.ajoms.2024.07.013","url":null,"abstract":"<div><h3>Object</h3><div>To differentiate between metastatic neck nodes and non-metastatic neck nodes in oral maxillary gingival squamous cell carcinoma, textural analysis of these lymph nodes in ultrasound images was performed in this study.</div></div><div><h3>Methods</h3><div>Twenty five metastatic neck nodes and 28 non-metastatic neck nodes were enrolled in this study. Seventy eight texture characteristics were retrieved from the US images using the LIFEx software.</div><div>The Mann Whitney U test was measurably utilized to survey on the off chance that there was a measurably noteworthy distinction within the textural characteristics between metastatic neck nodes and non-metastatic neck nodes. The capacity of the surface highlights to recognize between metastatic neck nodes and non-metastatic neck nodes was illustrated utilizing the Receiver Operating Characteristic analysis curves (ROC). Youden's J statistic was used to determine the cut-off positions in each ROC curve that maximized sensitivity and specificity.</div></div><div><h3>Results</h3><div>Zone size non uniformity (ZSNU) highlight appeared the foremost noteworthy contrast between these nodes (p < 0.001).</div><div>Strength had Area Under the Curve (AUC) of 0.811, specificity of 0.821 and sensitivity of 0.8, when measured at the cutoff value of 896.344.</div></div><div><h3>Conclusions</h3><div>Our results come about uncovered that quality highlight may be the finest surface highlight to distinguish from non-metastatic neck nodes and to anticipate metastatic neck nodes in oral maxillary gingival squamous cell carcinoma.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 70-75"},"PeriodicalIF":0.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral ranula is a cystic lesion that arises in the floor of the mouth, and various treatment methods for it have been proposed. Micro-marsupialization is a relatively new method that is easy to perform and minimally invasive; however, its efficacy has not been examined enough. We report a 14-year-old patient with oral ranula extending beyond midline to the contralateral sublingual caruncle who underwent micro-marsupialization and obtained a good outcome without notable complications. We also discuss and analyze the relevant literature. Among 88 previously reported patients with oral ranula, the cure rate with micro-marsupialization exceeded 90 %. We believe that micro-marsupialization can become a standard treatment for oral ranula.
{"title":"Could micro-marsupialization be an alternative treatment for Oral ranula? A case report and literature review","authors":"Miki Sugita , Hideo Tanaka , Chikara Ogawa , Eri Fukaya , Yutaro Hayashi , Kazuma Masumoto","doi":"10.1016/j.ajoms.2024.08.005","DOIUrl":"10.1016/j.ajoms.2024.08.005","url":null,"abstract":"<div><div>Oral ranula is a cystic lesion that arises in the floor of the mouth, and various treatment methods for it have been proposed. Micro-marsupialization is a relatively new method that is easy to perform and minimally invasive; however, its efficacy has not been examined enough. We report a 14-year-old patient with oral ranula extending beyond midline to the contralateral sublingual caruncle who underwent micro-marsupialization and obtained a good outcome without notable complications. We also discuss and analyze the relevant literature. Among 88 previously reported patients with oral ranula, the cure rate with micro-marsupialization exceeded 90 %. We believe that micro-marsupialization can become a standard treatment for oral ranula.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 318-322"},"PeriodicalIF":0.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syphilis, a sexually transmitted disease induced by the bacterium Treponema pallidum, presents with diverse progression-based symptoms, and its incidence has exhibited a rising trend in recent years. Syphilis is frequently identified not only by genital or skin lesions but also by lesions on the oral mucosa. However, the diagnosis of oral syphilis remains challenging because of the diverse array of oral symptoms. Although neurosyphilis manifests at any stage, unfamiliarity with neurological symptoms among oral surgeons can lead to overlooking the potential presence of neurosyphilis. To effectively diagnose the increasing number of syphilis cases, a precise understanding of diverse oral and systemic manifestations, including neurological symptoms, is crucial. In this report, we delineate the case of a 37-year-old female with oral syphilis who was diagnosed based on lesions on the tongue and soft palate, prompting the consideration of neurosyphilis.
{"title":"A case report of oral syphilis with suspected concomitant neurosyphilis","authors":"Hirokazu Kachi, Yosuke Harazono, Namiaki Takahara, Tetsuya Yoda","doi":"10.1016/j.ajoms.2024.08.007","DOIUrl":"10.1016/j.ajoms.2024.08.007","url":null,"abstract":"<div><div>Syphilis, a sexually transmitted disease induced by the bacterium <em>Treponema pallidum</em>, presents with diverse progression-based symptoms, and its incidence has exhibited a rising trend in recent years. Syphilis is frequently identified not only by genital or skin lesions but also by lesions on the oral mucosa. However, the diagnosis of oral syphilis remains challenging because of the diverse array of oral symptoms. Although neurosyphilis manifests at any stage, unfamiliarity with neurological symptoms among oral surgeons can lead to overlooking the potential presence of neurosyphilis. To effectively diagnose the increasing number of syphilis cases, a precise understanding of diverse oral and systemic manifestations, including neurological symptoms, is crucial. In this report, we delineate the case of a 37-year-old female with oral syphilis who was diagnosed based on lesions on the tongue and soft palate, prompting the consideration of neurosyphilis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 361-364"},"PeriodicalIF":0.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.1016/j.ajoms.2024.08.006
M. Hasan Hapid , Irna Sufiawati , Adji Kusumadjati , Emailsa Denta
Background
Radiation planning is a way to optimize dose at the radiation target volume and reduce the risk of radiotherapy side effects in the management of Head and Neck Cancer (HNC) obtained from the Treatment Planning System (TPS) process. It shows various distributions of radiation doses and can predict the location of toxicity that appears in the oral cavity. The purpose of this report was to describe the isodose curve as part of TPS to predict the severity of oral mucositis.
Case series presentation
Four patients with HNC aged 40–60 years, complained of canker sores and taste loss during radiotherapy for 3–6 weeks with exposure to 30–50 Gray radiation doses. Intraoral examination in all cases found ulceration covered by a yellowish-white pseudomembranous, surrounded by an erythematous erosive area. Three cases also found yellowish-white plaques that could be wiped leaving erythema areas. The diagnosis of oral mucositis grade 2–4 on the Radiation Therapy Oncology Group (RTOG) scale, oral candidiasis, and dysgeusia were made. Various distributions of radiation doses received in the oral cavity were as predicted at TPS and according to the location and severity of oral mucositis that occurs in patients.
Case management
All patients were given 0.025 % hyaluronic acid mouthwash, multivitamins, and instructions for maintaining oral hygiene and a balanced diet. Three patients with oral candidiasis were also given nystatin oral suspension 100.000 IU
Conclusion
Managing oral mucositis in radiotherapy for HNC patients remains challenging. Utilizing TPS results during radiation planning enables the prediction and prevention of oral mucositis.
{"title":"Evaluation of radiation planning in the development of acute radiation oral mucositis in head and neck cancer patients: A case series","authors":"M. Hasan Hapid , Irna Sufiawati , Adji Kusumadjati , Emailsa Denta","doi":"10.1016/j.ajoms.2024.08.006","DOIUrl":"10.1016/j.ajoms.2024.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Radiation planning is a way to optimize dose at the radiation target volume and reduce the risk of radiotherapy side effects in the management of Head and Neck Cancer (HNC) obtained from the Treatment Planning System (TPS) process. It shows various distributions of radiation doses and can predict the location of toxicity that appears in the oral cavity. The purpose of this report was to describe the isodose curve as part of TPS to predict the severity of oral mucositis.</div></div><div><h3>Case series presentation</h3><div>Four patients with HNC aged 40–60 years, complained of canker sores and taste loss during radiotherapy for 3–6 weeks with exposure to 30–50 Gray radiation doses. Intraoral examination in all cases found ulceration covered by a yellowish-white pseudomembranous, surrounded by an erythematous erosive area. Three cases also found yellowish-white plaques that could be wiped leaving erythema areas. The diagnosis of oral mucositis grade 2–4 on the Radiation Therapy Oncology Group (RTOG) scale, oral candidiasis, and dysgeusia were made. Various distributions of radiation doses received in the oral cavity were as predicted at TPS and according to the location and severity of oral mucositis that occurs in patients.</div></div><div><h3>Case management</h3><div>All patients were given 0.025 % hyaluronic acid mouthwash, multivitamins, and instructions for maintaining oral hygiene and a balanced diet. Three patients with oral candidiasis were also given nystatin oral suspension 100.000 IU</div></div><div><h3>Conclusion</h3><div>Managing oral mucositis in radiotherapy for HNC patients remains challenging. Utilizing TPS results during radiation planning enables the prediction and prevention of oral mucositis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 356-360"},"PeriodicalIF":0.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1016/j.ajoms.2024.08.001
Muhammad Osama Afzal , Fizza Khan
We are writing to express our appreciation for the insightful article by Narita et al. [1] titled “Incidental findings on preoperative head and neck MRI for orthognathic surgery in jaw deformity patients”. It was a pleasure to peruse this manuscript, and the authors’ endeavors on this subject are exceedingly valuable and merit acknowledgment from readers.
{"title":"Letter to the Editor: Incidental findings on preoperative head and neck MRI for orthognathic surgery in jaw deformity patients","authors":"Muhammad Osama Afzal , Fizza Khan","doi":"10.1016/j.ajoms.2024.08.001","DOIUrl":"10.1016/j.ajoms.2024.08.001","url":null,"abstract":"<div><div>We are writing to express our appreciation for the insightful article by Narita et al. [1] titled “Incidental findings on preoperative head and neck MRI for orthognathic surgery in jaw deformity patients”. It was a pleasure to peruse this manuscript, and the authors’ endeavors on this subject are exceedingly valuable and merit acknowledgment from readers.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 331-332"},"PeriodicalIF":0.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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