Pub Date : 2025-06-05DOI: 10.1016/j.ajoms.2025.06.002
Lorena dos Reis Pereira Queiroz, Fernando Veloso Caldeira Barcellos, Andréia Luiza Oliveira Costa, Vitória Regina Oliveira de Melo, Maria Rafaela Pereira Lacerda, André Luiz Sena Guimarães
Objective
To compile published works on molecular docking to verify its effectiveness in identifying bioactive compounds and potential biomarkers targeted at the treatment of oral squamous cell carcinoma (OSCC).
Methods
This systematic review follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and also registered in PROSPERO. The PubMed, Web of Science, Science Direct, and Google Scholar databases were used to search for articles. A tool, with adaptations, was used to assess the quality of the studies found.
Results
Fifty-three articles were included after checking all eligibility criteria. About proteins, Akt1, EGFR, HIF1a, among others, were identified as the most frequently occurring. Similarly, Quercetin, Epigallocatechin-3-gallate, Curcumin, Kaempferol, and Luteolin were the most prevalent among the compounds. The most commonly utilized databases for the retrieval of structures were PubChem and the RCSB Protein Data Bank. AutoDock, Maestro, AutoDock Vina, and PyMOL were some of the most used software.
Conclusions
Molecular docking has proven to be an effective tool for identifying potential biomarkers and bioactive compounds for treating OSCC.
目的整理已发表的分子对接研究成果，验证分子对接在鉴别口腔鳞癌（OSCC）靶向治疗生物活性化合物和潜在生物标志物方面的有效性。方法本系统评价遵循系统评价和荟萃分析首选报告项目的建议，并在PROSPERO上注册。使用PubMed、Web of Science、Science Direct和谷歌Scholar数据库搜索文章。使用一种具有适应性的工具来评估所发现研究的质量。结果经检查，纳入53篇文献。关于蛋白质，Akt1， EGFR， HIF1a等被确定为最常见的。同样，槲皮素、表没食子儿茶素-3-没食子酸酯、姜黄素、山奈酚和木犀草素是这些化合物中最普遍的。最常用的结构检索数据库是PubChem和RCSB Protein Data Bank。AutoDock, Maestro， AutoDock Vina和PyMOL是一些最常用的软件。结论分子对接是鉴别OSCC潜在生物标志物和生物活性化合物的有效工具。
{"title":"Molecular docking and molecules of interest for oral squamous cell carcinoma: A systematic review","authors":"Lorena dos Reis Pereira Queiroz, Fernando Veloso Caldeira Barcellos, Andréia Luiza Oliveira Costa, Vitória Regina Oliveira de Melo, Maria Rafaela Pereira Lacerda, André Luiz Sena Guimarães","doi":"10.1016/j.ajoms.2025.06.002","DOIUrl":"10.1016/j.ajoms.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>To compile published works on molecular docking to verify its effectiveness in identifying bioactive compounds and potential biomarkers targeted at the treatment of oral squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>This systematic review follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and also registered in PROSPERO. The PubMed, Web of Science, Science Direct, and Google Scholar databases were used to search for articles. A tool, with adaptations, was used to assess the quality of the studies found.</div></div><div><h3>Results</h3><div>Fifty-three articles were included after checking all eligibility criteria. About proteins, Akt1, EGFR, HIF1a, among others, were identified as the most frequently occurring. Similarly, Quercetin, Epigallocatechin-3-gallate, Curcumin, Kaempferol, and Luteolin were the most prevalent among the compounds. The most commonly utilized databases for the retrieval of structures were PubChem and the RCSB Protein Data Bank. AutoDock, Maestro, AutoDock Vina, and PyMOL were some of the most used software.</div></div><div><h3>Conclusions</h3><div>Molecular docking has proven to be an effective tool for identifying potential biomarkers and bioactive compounds for treating OSCC.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1159-1166"},"PeriodicalIF":0.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A retrospective study of 66 patients with oral squamous cell carcinoma was conducted, focusing on the outcomes and treatment-related adverse events of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia on metastatic lymph nodes.
Methods
The superficial temporal and occipital arteries were catheterized. The treatment consisted of superselective intra-arterial chemotherapy (docetaxel, 60 mg/m2; cisplatin, 150 mg/m2) and daily concurrent radiotherapy (60 Gy) combined with hyperthermia for 6 weeks. Hyperthermia was induced once or twice weekly for 50 min during chemoradiotherapy.
Results
The 3-year locoregional control and overall survival rates were 82 % and 78 %, respectively. Treatment-related adverse events included grade 3 and 4 oral mucositis in 97 % of patients, radiation dermatitis in 50 %, and grade 1 and 2 neck skin burns in 59 % of patients.
Conclusions
This combination therapy has led to good outcomes in patients with advanced oral cancer and lymph node metastases.
{"title":"Thermochemoradiation therapy using retrograde superselective intra-arterial infusion for patients with cervical lymph node metastases from advanced oral squamous cell carcinoma: A retrospective study of 66 cases","authors":"Toshiyuki Koizumi , Takashi Ohya , Masaki Iida , Yuichiro Hayashi , Senri Oguri , Toshinori Iwai , Mitomu Kioi , Kenji Mitsudo","doi":"10.1016/j.ajoms.2025.06.003","DOIUrl":"10.1016/j.ajoms.2025.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>A retrospective study of 66 patients with oral squamous cell carcinoma<span><span> was conducted, focusing on the outcomes and treatment-related adverse events of retrograde superselective intra-arterial </span>chemoradiotherapy<span> combined with hyperthermia on metastatic lymph nodes.</span></span></div></div><div><h3>Methods</h3><div><span>The superficial temporal and occipital arteries were catheterized. The treatment consisted of superselective intra-arterial chemotherapy (docetaxel, 60 mg/m</span><sup>2</sup><span>; cisplatin, 150 mg/m</span><sup>2</sup><span>) and daily concurrent radiotherapy (60 Gy) combined with hyperthermia for 6 weeks. Hyperthermia was induced once or twice weekly for 50 min during chemoradiotherapy.</span></div></div><div><h3>Results</h3><div>The 3-year locoregional control and overall survival<span><span> rates were 82 % and 78 %, respectively. Treatment-related adverse events included grade 3 and 4 oral mucositis in 97 % of patients, </span>radiation dermatitis in 50 %, and grade 1 and 2 neck skin burns in 59 % of patients.</span></div></div><div><h3>Conclusions</h3><div>This combination therapy has led to good outcomes in patients with advanced oral cancer and lymph node metastases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1196-1202"},"PeriodicalIF":0.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1016/j.ajoms.2025.06.001
Raniah Abdullah Al Eid
Objectives
A diverse set of lesions known as fibro-osseous lesions (FOLs) have overlapping clinical, radiological, and histopathological features, resulting in diagnostic and therapeutic challenges. Distinguishing between fibrous dysplasia (FD) and ossifying fibroma (OF) lesions is particularly difficult owing to their overlapping characteristics. Therefore, we conducted a systematic literature review of the molecular pathogenetic approaches for differentially diagnosing FD and OF.
Methods
Databases, including Web of Science, PubMed, Scopus, and the Cochrane Library, were used as data sources for this study. Data were obtained from a database using manual snowball searches and predefined search phrases. To prevent selection bias, independent reviewers conducted screening, and only 13 articles that directly addressed the research issue were included.
Results
Nine molecular differential diagnostic approaches for differentiating the two lesions were identified in the assessment of the included papers. The most popular molecular pathogenetic method for FD and OF differentiation was mutation analysis of the guanine nucleotide-binding protein alpha-subunit (GNAS) gene using various techniques, including pyrosequencing, direct DNA sequencing, polymerase chain reaction (PCR), real-time polymerase chain reaction (qPCR), high-resolution melting, and allele-specific PCR.
Conclusions
These molecular diagnostic options enable differentiation of FD and OF, but combining two or more techniques, particularly with other molecular markers alongside the GNAS mutation on exon 8, may further improve the differential diagnosis. We recommend clinical trials to combine these molecular options with other appropriate approaches to improve the differential diagnosis of FD and OF with increased detection sensitivity.
目的纤维-骨性病变（FOLs）具有重叠的临床、放射学和组织病理学特征，给诊断和治疗带来了挑战。区分纤维性发育不良（FD）和骨化性纤维瘤（OF）病变是特别困难的，因为它们的重叠特征。因此，我们对鉴别诊断FD和of的分子病理学方法进行了系统的文献综述。方法采用Web of Science、PubMed、Scopus、Cochrane Library等数据库作为本研究的数据来源。使用手动滚雪球搜索和预定义的搜索短语从数据库中获得数据。为防止选择偏倚，独立审稿人进行了筛选，只纳入了13篇直接涉及研究问题的文章。结果通过对文献的评价，确定了两种病变的分子鉴别诊断方法。FD和OF分化最流行的分子病理学方法是使用各种技术对鸟嘌呤核苷酸结合蛋白α -亚基（GNAS）基因进行突变分析，包括焦磷酸测序、直接DNA测序、聚合酶链反应（PCR）、实时聚合酶链反应（qPCR）、高分辨率熔化和等位基因特异性PCR。结论这些分子诊断方法能够区分FD和of，但结合两种或两种以上的技术，特别是与外显子8上GNAS突变的其他分子标记结合，可能进一步提高FD和of的鉴别诊断。我们建议临床试验将这些分子选择与其他适当的方法相结合，以提高FD和of的鉴别诊断，提高检测灵敏度。
{"title":"Molecular pathogenetic options for differentiating fibrous dysplasia and ossifying fibroma: A systematically conducted literature review","authors":"Raniah Abdullah Al Eid","doi":"10.1016/j.ajoms.2025.06.001","DOIUrl":"10.1016/j.ajoms.2025.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div><span>A diverse set of lesions known as fibro-osseous lesions (FOLs) have overlapping clinical, radiological, and histopathological features, resulting in diagnostic and therapeutic challenges. Distinguishing between fibrous dysplasia<span> (FD) and ossifying fibroma (OF) lesions is particularly difficult owing to their overlapping characteristics. Therefore, we conducted a </span></span>systematic literature review of the molecular pathogenetic approaches for differentially diagnosing FD and OF.</div></div><div><h3>Methods</h3><div><span>Databases, including Web of Science, PubMed, </span>Scopus<span>, and the Cochrane Library, were used as data sources for this study. Data were obtained from a database using manual snowball searches and predefined search phrases. To prevent selection bias, independent reviewers conducted screening, and only 13 articles that directly addressed the research issue were included.</span></div></div><div><h3>Results</h3><div><span><span>Nine molecular differential diagnostic approaches for differentiating the two lesions were identified in the assessment of the included papers. The most popular molecular pathogenetic method for FD and OF differentiation was mutation analysis of the guanine nucleotide-binding protein alpha-subunit (GNAS) gene using various techniques, including </span>pyrosequencing, direct </span>DNA sequencing<span>, polymerase chain reaction<span> (PCR), real-time polymerase chain reaction (qPCR), high-resolution melting, and allele-specific PCR.</span></span></div></div><div><h3>Conclusions</h3><div><span>These molecular diagnostic<span> options enable differentiation of FD and OF, but combining two or more techniques, particularly with other molecular markers alongside the GNAS mutation on exon 8, may further improve the differential diagnosis. We recommend </span></span>clinical trials to combine these molecular options with other appropriate approaches to improve the differential diagnosis of FD and OF with increased detection sensitivity.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1283-1293"},"PeriodicalIF":0.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-29DOI: 10.1016/j.ajoms.2025.05.011
Makoto Adachi , Naoki Umemura
Oral cancer, especially oral squamous cell carcinoma (OSCC), remains a significant global health problem due to poor prognosis and high mortality despite advances in conventional treatment. DNA repair mechanisms are essential for maintaining genomic stability and influencing both oral cancer development and treatment response. In this review, we discuss the current understanding of DNA repair pathways in oral cancer, their clinical significance, and potential therapeutic applications. We systematically reviewed the literature and analyzed studies on DNA repair mechanisms, their dysregulation in oral cancer, and emerging targeted therapies. Key findings indicate that DNA repair defects are prevalent in OSCC, contributing to genomic instability and resistance to DNA-damaging therapies. Tobacco, alcohol, and chronic inflammation are major carcinogenic factors that cause widespread DNA damage and often overwhelm cellular repair systems. Epigenetic modifications further exacerbate repair failure, affecting tumor progression and treatment outcomes. Recent advances demonstrate the efficacy of DNA repair-targeted strategies, especially poly ADP-ribose polymerase (PARP) inhibitors, which hold promise for homologous recombination-deficient tumors. Furthermore, DNA repair status has emerged as a valuable biomarker for prognostic applications and can guide patient selection for precision medicine approaches. However, resistance mechanisms to DNA repair inhibitors, such as pathway rewiring and compensatory repair activation, remain a major challenge. Future studies should focus on integrating DNA repair assessment into clinical decision-making, refining biomarker strategies, and developing rational combination therapies to overcome resistance. A deeper understanding of DNA repair dynamics in oral cancer may lead to more effective and personalized treatment strategies, ultimately improving patient outcomes.
{"title":"DNA repair mechanisms and their therapeutic implications in oral cancer","authors":"Makoto Adachi , Naoki Umemura","doi":"10.1016/j.ajoms.2025.05.011","DOIUrl":"10.1016/j.ajoms.2025.05.011","url":null,"abstract":"<div><div>Oral cancer, especially oral squamous cell carcinoma (OSCC), remains a significant global health problem due to poor prognosis and high mortality despite advances in conventional treatment. DNA repair mechanisms are essential for maintaining genomic stability and influencing both oral cancer development and treatment response. In this review, we discuss the current understanding of DNA repair pathways in oral cancer, their clinical significance, and potential therapeutic applications. We systematically reviewed the literature and analyzed studies on DNA repair mechanisms, their dysregulation in oral cancer, and emerging targeted therapies. Key findings indicate that DNA repair defects are prevalent in OSCC, contributing to genomic instability and resistance to DNA-damaging therapies. Tobacco, alcohol, and chronic inflammation are major carcinogenic factors that cause widespread DNA damage and often overwhelm cellular repair systems. Epigenetic modifications further exacerbate repair failure, affecting tumor progression and treatment outcomes. Recent advances demonstrate the efficacy of DNA repair-targeted strategies, especially poly ADP-ribose polymerase (PARP) inhibitors, which hold promise for homologous recombination-deficient tumors. Furthermore, DNA repair status has emerged as a valuable biomarker for prognostic applications and can guide patient selection for precision medicine approaches. However, resistance mechanisms to DNA repair inhibitors, such as pathway rewiring and compensatory repair activation, remain a major challenge. Future studies should focus on integrating DNA repair assessment into clinical decision-making, refining biomarker strategies, and developing rational combination therapies to overcome resistance. A deeper understanding of DNA repair dynamics in oral cancer may lead to more effective and personalized treatment strategies, ultimately improving patient outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1273-1282"},"PeriodicalIF":0.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-26DOI: 10.1016/j.ajoms.2025.05.012
P. Rajesh , R. Jino Affrald , Shoba Narayan
Objective
Complications such as dry sockets and infections are very common after tooth extraction and it can be prevented with proper care and precautions. Most common techniques of preventing these complications include maintaining good oral hygiene, and using specific materials to support healing in the socket to enhance recovery by reducing the chance of infection. In order to overcome such complications associated with socket healing after extraction of tooth, bone substitute materials are more commonly used. This study aims to explore the use of platelet-rich fibrin (PRF), metal nanoparticles, and biopolymers in enhancing the healing process. However, chitosan has shown to improve wound healing by attracting and activating neutrophils and macrophages and also by enhancing angiogenesis. While metal nanoparticles assist in preventing infections.
Methods
This review was conducted by searching relevant literature articles from Google Scholar and PubMed using different keywords related to the research topic.
Results
Literature supports that the use of PRF, metal nanoparticles, and biopolymers individually shows significant potential in promoting socket healing after extraction of tooth. However, each materials are associated with specific limitations including difficulty in handling PRF, the cytotoxicity of certain metal nanoparticles, and the biodegradability concerns of biopolymers.
Conclusions
Combining PRF, metal nanoparticles and chitosan could present a synergistic multifaceted approach to overcome limitations associated with each material and accelerate the socket healing process. This combined material could offer a more effective solution for improving clinical outcomes in oral and maxillofacial surgery.
{"title":"Innovative approach for dental socket healing using PRF-enriched metal nanocomposites – A comprehensive review","authors":"P. Rajesh , R. Jino Affrald , Shoba Narayan","doi":"10.1016/j.ajoms.2025.05.012","DOIUrl":"10.1016/j.ajoms.2025.05.012","url":null,"abstract":"<div><h3>Objective</h3><div>Complications such as dry sockets and infections are very common after tooth extraction and it can be prevented with proper care and precautions. Most common techniques of preventing these complications include maintaining good oral hygiene, and using specific materials to support healing in the socket to enhance recovery by reducing the chance of infection. In order to overcome such complications associated with socket healing after extraction of tooth, bone substitute materials are more commonly used. This study aims to explore the use of platelet-rich fibrin (PRF), metal nanoparticles, and biopolymers in enhancing the healing process. However, chitosan has shown to improve wound healing by attracting and activating neutrophils and macrophages and also by enhancing angiogenesis. While metal nanoparticles assist in preventing infections.</div></div><div><h3>Methods</h3><div>This review was conducted by searching relevant literature articles from Google Scholar and PubMed using different keywords related to the research topic.</div></div><div><h3>Results</h3><div>Literature supports that the use of PRF, metal nanoparticles, and biopolymers individually shows significant potential in promoting socket healing after extraction of tooth. However, each materials are associated with specific limitations including difficulty in handling PRF, the cytotoxicity of certain metal nanoparticles, and the biodegradability concerns of biopolymers.</div></div><div><h3>Conclusions</h3><div>Combining PRF, metal nanoparticles and chitosan could present a synergistic multifaceted approach to overcome limitations associated with each material and accelerate the socket healing process. This combined material could offer a more effective solution for improving clinical outcomes in oral and maxillofacial surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 864-876"},"PeriodicalIF":0.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Squamous cell carcinoma (SCC) rarely arises from the epithelial lining of odontogenic cysts, and is referred to as primary intraosseous squamous cell carcinoma (PISCC), which mainly originates from long-standing odontogenic cysts. The incidence of malignant changes in odontogenic cysts is between 0.3 % and 3 %. Approximately 25 % of PISCC derived from odontogenic cysts had a dysplastic lining. The report aims to describe an unusual occurrence of dysplastic changes in the epithelial lining of an odontogenic cyst with keratinization that was primarily diagnosed as an odontogenic keratocyst.
{"title":"Dysplastic epithelial changes in an odontogenic cyst with keratinization: A rare occurrence","authors":"Alireza Pournabi , Zahra Zolfaghari Saravi , Naghi Abbaszadeh , Hossein Ghorbani","doi":"10.1016/j.ajoms.2025.05.015","DOIUrl":"10.1016/j.ajoms.2025.05.015","url":null,"abstract":"<div><div>Squamous cell carcinoma (SCC) rarely arises from the epithelial lining of odontogenic cysts<span><span>, and is referred to as primary intraosseous squamous cell carcinoma (PISCC), which mainly originates from long-standing odontogenic cysts. The incidence of malignant changes in odontogenic cysts is between 0.3 % and 3 %. Approximately 25 % of PISCC derived from odontogenic cysts had a dysplastic lining. The report aims to describe an unusual occurrence of dysplastic changes in the epithelial lining of an odontogenic cyst with keratinization that was primarily diagnosed as an </span>odontogenic keratocyst.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1309-1313"},"PeriodicalIF":0.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dental implants are widely used for tooth replacement, contributing to both aesthetics and functionality. This narrative review examines the peri-implant corticalization phenomenon—the transformation of trabecular bone to cortical bone around implants following functional loading—and explores its impact on implant longevity.
Methods
A systematic search across databases including MEDLINE, Web of Science, Google Scholar, EMBASE, Scopus, and the Cochrane Library identified studies relevant to peri-implant corticalization post-implant loading. Studies were screened for relevance based on inclusion criteria, focusing on the influence of corticalization on implant success.
Results
Of 114 initially identified articles, 86 were screened, and 8 met full inclusion criteria. The review highlights corticalization as a significant factor in peri-implant bone remodeling, frequently linked with marginal bone loss (MBL). Factors influencing corticalization include patient-specific aspects (e.g., smoking, body mass index [BMI], hormone levels), implant design (e.g., thread type, placement depth), and prosthetic choices (e.g., single crowns vs. bridges). Notably, higher corticalization is associated with increased MBL, potentially compromising implant stability. Implants with design features like microthreads or apical grooves, subcrestal placement, and lower insertion torque show reduced corticalization, thereby enhancing long-term outcomes.
Conclusion
Peri-implant corticalization, while an adaptive bone remodeling response to implant loading, is associated with adverse outcomes, including MBL and potential implant failure over time. Implant design, patient health, and placement techniques play critical roles in modulating corticalization, underscoring the need for targeted clinical planning to enhance implant success. This review advocates for further research to clarify corticalization’s long-term impact and refine implant protocols for improved patient outcomes.
目的种植体在牙齿置换中应用广泛，具有美观性和功能性。本文回顾了种植体周围的皮质化现象——在功能负荷下种植体周围的小梁骨向皮质骨的转变——并探讨了其对种植体寿命的影响。方法系统检索MEDLINE、Web of Science、谷歌Scholar、EMBASE、Scopus和Cochrane Library等数据库，确定与种植体周围皮质化相关的研究。根据纳入标准筛选相关研究，重点关注皮质化对种植体成功的影响。结果在114篇初步确定的文章中，86篇被筛选，8篇符合完全纳入标准。该综述强调皮质化是种植体周围骨重塑的重要因素，经常与边缘性骨丢失（MBL）相关。影响皮质化的因素包括患者特定方面（例如，吸烟、体重指数[BMI]、激素水平）、种植体设计（例如，螺纹类型、放置深度）和假体选择（例如，单冠还是桥）。值得注意的是，较高的皮质化与MBL增加有关，可能会损害种植体的稳定性。植入物的设计特点如微螺纹或根尖凹槽、牙冠下放置和较低的插入扭矩可减少皮质化，从而提高长期疗效。结论种植体周围皮质化虽然是对种植体负荷的适应性骨重塑反应，但随着时间的推移与不良后果相关，包括MBL和潜在的种植体失效。种植体设计、患者健康和放置技术在调节皮质化中起着关键作用，强调需要有针对性的临床计划来提高种植体的成功率。这篇综述提倡进一步的研究，以澄清皮质化的长期影响，并完善种植方案，以改善患者的预后。
{"title":"Corticalization around dental implants: A narrative review of the literature","authors":"Behzad Houshmand , Mahdiye Fasihi Ramandi , Zahra Shooshtari , Shivam Patel , Hamoun Sabri","doi":"10.1016/j.ajoms.2025.05.010","DOIUrl":"10.1016/j.ajoms.2025.05.010","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental implants are widely used for tooth replacement, contributing to both aesthetics and functionality. This narrative review examines the peri-implant corticalization phenomenon—the transformation of trabecular bone to cortical bone around implants following functional loading—and explores its impact on implant longevity.</div></div><div><h3>Methods</h3><div>A systematic search across databases including MEDLINE, Web of Science, Google Scholar, EMBASE, Scopus, and the Cochrane Library identified studies relevant to peri-implant corticalization post-implant loading. Studies were screened for relevance based on inclusion criteria, focusing on the influence of corticalization on implant success.</div></div><div><h3>Results</h3><div>Of 114 initially identified articles, 86 were screened, and 8 met full inclusion criteria. The review highlights corticalization as a significant factor in peri-implant bone remodeling, frequently linked with marginal bone loss (MBL). Factors influencing corticalization include patient-specific aspects (e.g., smoking, body mass index [BMI], hormone levels), implant design (e.g., thread type, placement depth), and prosthetic choices (e.g., single crowns vs. bridges). Notably, higher corticalization is associated with increased MBL, potentially compromising implant stability. Implants with design features like microthreads or apical grooves, subcrestal placement, and lower insertion torque show reduced corticalization, thereby enhancing long-term outcomes.</div></div><div><h3>Conclusion</h3><div>Peri-implant corticalization, while an adaptive bone remodeling response to implant loading, is associated with adverse outcomes, including MBL and potential implant failure over time. Implant design, patient health, and placement techniques play critical roles in modulating corticalization, underscoring the need for targeted clinical planning to enhance implant success. This review advocates for further research to clarify corticalization’s long-term impact and refine implant protocols for improved patient outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 857-863"},"PeriodicalIF":0.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multiple salivary gland tumors (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor salivary glands has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for > 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.
Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or metastasis was noted 3 years after surgery.
{"title":"A case of multiple minor salivary gland tumors with synchronous carcinoma ex pleomorphic adenoma and pleomorphic adenoma","authors":"Akio Shibata , Kou Kawahara , Yutaro Kondo , Kumiko Hatsukawa , Yuki Tange , Satoru Miyabe","doi":"10.1016/j.ajoms.2025.05.009","DOIUrl":"10.1016/j.ajoms.2025.05.009","url":null,"abstract":"<div><div>Multiple salivary gland tumors<span><span> (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor </span>salivary glands<span> has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for > 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.</span></span></div><div><span>Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or </span>metastasis was noted 3 years after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1304-1308"},"PeriodicalIF":0.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-18DOI: 10.1016/j.ajoms.2025.04.015
Kiwako Izumi , Tsuyoshi Moriyama
Objective
This study evaluated the changes in cheek soft tissue after orthognathic surgery using facial photographs and cephalograms. Cheek soft tissue was defined as the cheek line, which is the contour of the cheek starting from the infraorbital region and continuing to the corners of the mouth on a lateral photograph.
Methods
Seventy-eight Japanese patients (48 females and 30 males) with skeletal class III underwent maxillary advancement, clockwise rotation, and mandibular setback. The changes in cheek size and the position of the cheek points on the cheek line after orthognathic surgery were examined experimentally using a previously proposed image analysis software program.
Results
The maxillary advancement was 4.4 mm, the clockwise rotation was 2.8 mm, and the mandibular setback was 4.4 mm, and there was no significant sex difference in skeletal movement. The ratio of change in cheek size increased (mean 2.7) and showed an anterior change at the points on the cheek line. The change in cheek point showed a significant sex difference; the upper cheeks were more advanced in males. Cheek changes were positively correlated only with maxillary advancement, and the upper cheek points in men was also showed a correlation.
Conclusion
Orthognathic surgery for skeletal class III affected cheek bulge, and maxillary advancement had a greater effect on the cheek line. There were sex differences in the postoperative changes in the cheek line, with the changes in the cheek contour in females increasing radially, whereas the changes in males tended to be similar to skeletal movement.
{"title":"Morphological changes of cheek soft tissue due to orthognathic surgery of maxillary advancement, rotation, and mandibular setback","authors":"Kiwako Izumi , Tsuyoshi Moriyama","doi":"10.1016/j.ajoms.2025.04.015","DOIUrl":"10.1016/j.ajoms.2025.04.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the changes in cheek soft tissue after orthognathic surgery using facial photographs and cephalograms. Cheek soft tissue was defined as the cheek line, which is the contour of the cheek starting from the infraorbital region and continuing to the corners of the mouth on a lateral photograph.</div></div><div><h3>Methods</h3><div>Seventy-eight Japanese patients (48 females and 30 males) with skeletal class III underwent maxillary advancement, clockwise rotation, and mandibular setback. The changes in cheek size and the position of the cheek points on the cheek line after orthognathic surgery were examined experimentally using a previously proposed image analysis software program.</div></div><div><h3>Results</h3><div>The maxillary advancement was 4.4 mm, the clockwise rotation was 2.8 mm, and the mandibular setback was 4.4 mm, and there was no significant sex difference in skeletal movement. The ratio of change in cheek size increased (mean 2.7) and showed an anterior change at the points on the cheek line. The change in cheek point showed a significant sex difference; the upper cheeks were more advanced in males. Cheek changes were positively correlated only with maxillary advancement, and the upper cheek points in men was also showed a correlation.</div></div><div><h3>Conclusion</h3><div>Orthognathic surgery for skeletal class III affected cheek bulge, and maxillary advancement had a greater effect on the cheek line. There were sex differences in the postoperative changes in the cheek line, with the changes in the cheek contour in females increasing radially, whereas the changes in males tended to be similar to skeletal movement.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 941-946"},"PeriodicalIF":0.4,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skin grafting is a less invasive option for reconstruction following the excision of buccal mucosal cancer and can help prevent trismus. Although it is a valuable method, skin survival rates have traditionally been suboptimal. We report a high skin engraftment rate achieved by performing full-thickness skin grafts for buccal mucosal cancer up to T-stage III, coupled with tumor excision using cold devices instead of an electric knife.
Methods
This study analyzed 15 cases of full-thickness skin grafting performed on the patients with buccal mucosal cancer who visited our department between April 2016 and December 2023. Radical surgery was performed, with skin fixation achieved through tying and applying an anchor suture. The primary outcome was the engraftment rate of the grafted skin, and explanatory factors included age, sex, tumor site, the extent of resection, depth, device used for tumor resection, and use of a buccal fat pad.
Results
The mean age of the enrolled patients (n = 15) was 74.5 (range, 35–96) years. Of the 15 cases analyzed, 7 and 8 were in the electric knife and cold device groups, respectively. Univariate analysis revealed that resection below the buccal muscle and the use of cold devices were significantly associated with a higher engraftment rate. Multivariate analysis confirmed that a smaller resection area and the use of cold devices were significantly associated with better skin engraftment outcomes.
Conclusion
The use of cold devices during the resection of buccal mucosa cancer significantly improves the engraftment rate of full-thickness skin grafts.
{"title":"Use of cold devices for tumor resection improves the engraftment rate of full-thickness skin grafts in buccal mucosal cancer","authors":"Yoshio Ohyama , Yasuyuki Michi , Yoshinori Inaba , Kazuki Hasegawa","doi":"10.1016/j.ajoms.2025.05.007","DOIUrl":"10.1016/j.ajoms.2025.05.007","url":null,"abstract":"<div><h3>Objective</h3><div><span><span>Skin grafting<span> is a less invasive option for reconstruction following the excision of buccal mucosal cancer and can help prevent </span></span>trismus. Although it is a valuable method, skin survival rates have traditionally been suboptimal. We report a high skin </span>engraftment rate achieved by performing full-thickness skin grafts for buccal mucosal cancer up to T-stage III, coupled with tumor excision using cold devices instead of an electric knife.</div></div><div><h3>Methods</h3><div>This study analyzed 15 cases of full-thickness skin grafting performed on the patients with buccal mucosal cancer who visited our department between April 2016 and December 2023. Radical surgery was performed, with skin fixation achieved through tying and applying an anchor suture. The primary outcome was the engraftment rate of the grafted skin, and explanatory factors included age, sex, tumor site, the extent of resection, depth, device used for tumor resection, and use of a buccal fat pad.</div></div><div><h3>Results</h3><div>The mean age of the enrolled patients (n = 15) was 74.5 (range, 35–96) years. Of the 15 cases analyzed, 7 and 8 were in the electric knife and cold device groups, respectively. Univariate analysis<span> revealed that resection below the buccal muscle and the use of cold devices were significantly associated with a higher engraftment rate. Multivariate analysis confirmed that a smaller resection area and the use of cold devices were significantly associated with better skin engraftment outcomes.</span></div></div><div><h3>Conclusion</h3><div>The use of cold devices during the resection of buccal mucosa cancer significantly improves the engraftment rate of full-thickness skin grafts.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1181-1185"},"PeriodicalIF":0.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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