Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第10页

Identification of clinical, prognostic and immunological impact of replication factor C subunit 5 (RFC5) expression in head and neck squamous cell carcinoma 复制因子C亚单位5 （RFC5）在头颈部鳞状细胞癌中表达的临床、预后和免疫学影响的鉴定

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-04-27 DOI: 10.1016/j.ajoms.2025.04.014

Dakshitha Sankar , Anitha Pandi , Palati Sinduja , Vijayashree Priyadharsini Jayaseelan , Paramasivam Arumugam

Objectives

This study aimed to identify and validate replication factor C subunit 5 (RFC5) mRNA and protein expression in head and neck squamous cell carcinoma (HNSCC) patients, analyzing its association with clinicopathological features, prognosis, and immune signatures.

Methods

The study primarily relied on the cancer genome atlas (TCGA-HNSCC) dataset and additionally recruited 32 OSCC patients, a common type of cancer in HNSCC. RFC5 mRNA and protein expression were analyzed in oral squamous cell carcinoma (OSCC) and adjacent normal tissues using methods such as real time-qPCR and Western blot. The implications of RFC5 expression in clinicopathological features, survival, immune regulation, and functional enrichment analysis were analyzed using the TCGA-HNSCC dataset.

Results

RFC5 mRNA and protein are significantly altered in multiple cancers, particularly upregulated in HNSCC/OSCC. RFC5 mRNA expression is associated with cancer stage, grade, nodal metastasis, HPV status, and poor prognosis, suggesting its potential as a biomarker. Protein network analysis identified an interaction between RFC5 and various well-known oncoproteins involved in DNA replication and cancer pathways. Functional enrichment analysis showed a strong association between RFC5 and HNSCC development and progression.

Conclusions

RFC5 is a key player in HNSCC, and its overexpression is associated with aggressive clinical features and poor outcomes. Its role in oncogenic pathways and interaction with key proteins suggest its potential as a biomarker and therapeutic target.

目的鉴定和验证复制因子C亚基5 (RFC5) mRNA和蛋白在头颈部鳞状细胞癌（HNSCC）患者中的表达，分析其与临床病理特征、预后和免疫特征的关系。方法本研究主要依靠癌症基因组图谱（TCGA-HNSCC）数据集，另外招募了32例OSCC患者，OSCC是HNSCC中常见的一种癌症。采用real - time-qPCR和Western blot等方法分析口腔鳞癌（OSCC）及癌旁正常组织中RFC5 mRNA和蛋白的表达。使用TCGA-HNSCC数据集分析RFC5表达在临床病理特征、生存、免疫调节和功能富集分析中的意义。结果rfc5 mRNA和蛋白在多种肿瘤中表达显著改变，在HNSCC/OSCC中表达上调。RFC5 mRNA表达与癌症分期、分级、淋巴结转移、HPV状态和不良预后相关，提示其作为生物标志物的潜力。蛋白质网络分析确定了RFC5与参与DNA复制和癌症途径的各种已知癌蛋白之间的相互作用。功能富集分析显示，RFC5与HNSCC的发生发展密切相关。结论srfc5在HNSCC中起关键作用，其过表达与侵袭性临床特征和不良预后相关。它在致癌途径中的作用以及与关键蛋白的相互作用表明它具有作为生物标志物和治疗靶点的潜力。

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引用次数: 0

A unique presentation of spongiotic hyperplasia at the mucogingival junction 牙龈粘膜交界处海绵状增生的独特表现

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-04-16 DOI: 10.1016/j.ajoms.2025.04.008

Karanbir Sidhu , Kale Wudrich , Matheus de Castro Costa , Amanda Gruza , Marina Lara de Carli , Felipe Fornias Sperandio

Introduction

Spongiotic Gingival Hyperplasia (SGH), previously known as Localized Juvenile Spongiotic Gingival Hyperplasia (LJSGH), has been a subject of nomenclature debate due to its presentation in patients of all ages. SGH is characterized by erythematous, slightly raised plaques or nodules, often localized in the marginal gingiva. This case report presents a unique clinical presentation of Spongiotic Hyperplasia of the Mucogingival Junction (SHMJ), further elucidating SGH's clinical variability, with a particular focus on its differential diagnosis and management, followed by long-term clinical monitoring.

Case Report

A 67-year-old female presented with an asymptomatic, erythematous patch at the mucogingival junction between teeth #21 and #22. Clinical and radiographic examination revealed no signs of periodontal or pulpal infection/necrosis. An excisional biopsy of the lesion revealed marked spongiosis and exocytosis of a diffusely CK19-positive overlying mucosal epithelium. Histological findings were consistent with spongiotic hyperplasia. The lesion showed complete healing at a 9-month follow-up without recurrence.

Conclusion

This case represents a peculiar instance of SHMJ, highlighting the need for heightened clinical awareness of SGH’s atypical presentations. Surgical excision remains the treatment of choice, as conservative periodontal treatments are ineffective. Histological and immunohistochemical analysis aid in definitive diagnosis; long-term follow-up is essential to exclude recurrence.

海绵状牙龈增生症（SGH），以前被称为局限性青少年海绵状牙龈增生症（LJSGH），由于其在所有年龄段的患者中表现出来，一直是命名争议的主题。SGH的特征是红斑，轻微凸起的斑块或结节，通常局限于边缘牙龈。本病例报告提出了粘膜牙龈交界处海绵状增生症（SHMJ）的独特临床表现，进一步阐明了SGH的临床变异性，特别关注其鉴别诊断和治疗，随后进行长期临床监测。病例报告：一名67岁女性，在21号和22号牙齿之间的粘膜交界处出现无症状的红斑斑块。临床及影像学检查未见牙周或牙髓感染/坏死征象。病变的切除活检显示明显的海绵状病变和弥漫性ck19阳性粘膜上皮的胞吐。组织学表现与海绵状增生一致。在9个月的随访中，病变完全愈合，无复发。结论：该病例是SHMJ的一个特殊病例，强调了提高临床对SGH非典型表现认识的必要性。手术切除仍然是治疗的选择，因为保守的牙周治疗是无效的。组织学和免疫组织化学分析有助于明确诊断；长期随访是排除复发的必要条件。

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引用次数: 0

A case of improvement of restricted mouth opening caused by buccal mucosa scar using nasolabial flap 鼻唇瓣改善口腔黏膜瘢痕所致狭窄开口一例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-02-07 DOI: 10.1016/j.ajoms.2025.02.003

Arun Kumar Mahat , Ayaka Abe , Kana Kuribayashi , Kenji Kawano

Restricted mouth opening after oral cancer treatment is a secondary complication caused by scarring of leading to difficulty in eating, chewing, swallowing, breathing and speaking; resulting in poor oral health with psychological difficulties and negative impact on Quality of Life (QoL). There is no specific treatment for trismus and current strategies emphasize on prevention using conservative therapy and surgical resection of scar tissues with reconstruction in cases where conservative therapy is inadequate. Despite the availability of plethora of reconstructive options nasolabial flap with its robust blood supply based on facial artery and proximity to oral cavity requires simpler surgical technique, less time for flap harvest and inset; has improved success rate and is versatile enough to cover both small and large defect with scars that are often well-concealed within the natural nasolabial fold. Herein, we present a case of restricted mouth opening caused by buccal mucosa scar contracture following resection of malignant tumor. The patient underwent surgical resection of scar tissue and a single step technique nasolabial flap reconstruction demonstrating a successful outcome.

口腔癌治疗后张嘴受限是由疤痕导致进食、咀嚼、吞咽、呼吸和说话困难的继发并发症；导致口腔健康状况不佳，伴有心理困难，并对生活质量产生负面影响。对于牙关没有特殊的治疗方法，目前的策略强调使用保守治疗进行预防，在保守治疗不足的情况下手术切除瘢痕组织并重建。鼻唇瓣以面动脉为基础，靠近口腔，供血能力强，手术技术简单，皮瓣移植时间短。有提高的成功率，是万能的足以覆盖大小缺陷的疤痕，往往很好地隐藏在自然鼻唇沟。在此，我们报告一例恶性肿瘤切除术后因颊黏膜瘢痕挛缩而导致开口受限的病例。患者接受手术切除瘢痕组织和一步技术鼻唇瓣重建显示成功的结果。

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引用次数: 0

Disseminated herpes zoster presenting as atypical Ramsay-Hunt syndrome with oral lesions: A case report 播散性带状疱疹表现为非典型拉姆齐-亨特综合征伴口腔病变：1例报告

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-02-12 DOI: 10.1016/j.ajoms.2025.02.010

Saki Maruyama , Norihisa Ichimura , Yukiko Wakayama , Masahiro Omori , Kohei Sakaguchi , Kazuto Okabe , Hiroshi Maruyama , Hideharu Hibi

Shingles is caused by reactivation of latent varicella-zoster virus infection and can become generalized if immunity is weakened for any reason. Ramsay-Hunt syndrome is a rare manifestation of varicella-zoster virus reactivation. According to Goswami and Gaurkar (2023), it accounts for less than 1 % of cases. The disease is classified as typical or atypical according to the clinical manifestations. We present a rare case of an 87-year-old woman with atypical Ramsay-Hunt syndrome and disseminated herpes zoster. At the initial examination, the only findings were vesicles on the palate and white moss-like lesions on the tongue. The following day, the patient developed right otalgia and herpes zoster was suspected. Antiviral drug administration was initiated immediately. On Day 2 of hospitalization, a disseminated vesicular eruption and right facial nerve paralysis appeared. However, vesicles did not appear in the ear canal or pinna and no vestibulocochlear dysfunction was observed; therefore, we diagnosed atypical Ramsay-Hunt syndrome with disseminated herpes zoster. The rash and right facial nerve paralysis persisted. Herpes zoster, even if confined to oral mucosa, is an important sign that should raise suspicion of incomplete Ramsay-Hunt syndrome. Ramsay-Hunt syndrome can cause severe and persistent symptoms; therefore, it should be diagnosed and treated as early as possible.

带状疱疹是由潜伏的水痘带状疱疹病毒感染的再激活引起的，如果免疫力因任何原因减弱，带状疱疹可能会变得普遍。拉姆齐-亨特综合征是水痘带状疱疹病毒再激活的一种罕见表现。根据Goswami和Gaurkar(2023)，它占不到1% %的病例。该病根据临床表现分为典型和不典型。我们提出一个罕见的病例，87岁的妇女与非典型拉姆齐-亨特综合征和播散性带状疱疹。在最初的检查中，唯一的发现是上颚上的小泡和舌头上的白色苔藓样病变。次日，患者出现右耳痛，怀疑为带状疱疹。立即开始使用抗病毒药物。住院第2天出现弥漫性水疱疹及右侧面神经麻痹。耳道、耳廓未见囊泡，前庭耳蜗未见功能障碍；因此，我们诊断不典型拉姆齐-亨特综合征伴有播散性带状疱疹。皮疹和右侧面神经麻痹持续存在。带状疱疹，即使局限于口腔粘膜，也是一个重要的迹象，应该引起不完全拉姆齐-亨特综合征的怀疑。拉姆齐-亨特综合征可引起严重和持续的症状；因此，应尽早诊断和治疗。

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引用次数: 0

Osteosarcoma of the jaw in an adult patient aged more than 40 years successfully treated with neoadjuvant chemotherapy comprising doxorubicin and ifosfamide: A case report 年龄超过40岁的成人颌骨骨肉瘤患者成功地接受了由阿霉素和异环磷酰胺组成的新辅助化疗：1例报告

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-03-26 DOI: 10.1016/j.ajoms.2025.03.008

Yusuke Tsuda , Masanobu Abe , Kenichi Kumagai , Toshihiro Kikuta , Kazuto Hoshi

Although the mandible is the fourth most common site for osteosarcoma, the standard treatment for these patients remains unclear. A 59-year-old woman presented with mandibular pain. Imaging studies revealed a bone-forming mass with extraosseous extension in the mandible. Biopsy results revealed spindle-to-stellate tumour cells with irregular nuclei and osteoid formation, indicating high-grade osteosarcoma. After preoperative chemotherapy with doxorubicin and ifosfamide, osteosarcoma of the jaw was resected with adequate margins. Histological analysis revealed > 90 % tumour necrosis. Patients achieving a tumour necrosis rate of > 90 % after preoperative chemotherapy have shown significantly better prognoses than those with a necrosis rate of < 90 % in osteosarcoma of the extremities and trunk. Although no consensus has been reached on the effectiveness of preoperative chemotherapy for osteosarcoma of the jaw or osteosarcoma in patients aged > 40 years, neoadjuvant chemotherapy with doxorubicin and ifosfamide may achieve favorable oncological outcomes in selected patients aged > 40 years with high-grade osteosarcoma of the jaw.

虽然下颌骨是骨肉瘤的第四大常见部位，但对这些患者的标准治疗仍不清楚。一名59岁女性，以下颌骨疼痛为主诉。影像学检查显示下颌骨有骨外延伸的骨形成肿块。活检结果显示梭形到星形的肿瘤细胞，细胞核不规则，骨样形成，提示高级别骨肉瘤。术前用阿霉素和异环磷酰胺化疗后，切除颌骨骨肉瘤，留下足够的切缘。组织学分析显示>； 90 %肿瘤坏死。术前化疗后肿瘤坏死率为 90 %的患者预后明显优于四肢和躯干骨肉瘤坏死率为 90 %的患者。虽然对于年龄>； 40岁的颌骨骨肉瘤或骨肉瘤患者术前化疗的有效性尚未达成共识，但对于年龄>； 40岁的颌骨高级别骨肉瘤患者，阿霉素和异环磷酰胺的新辅助化疗可能会取得良好的肿瘤学结果。

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引用次数: 0

Metachronous occurrence of Epstein-Barr virus-positive mucocutaneous ulcers suspected to be related to periodontitis: A case report 怀疑与牙周炎有关的eb病毒阳性皮肤粘膜溃疡同时发生1例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-04-11 DOI: 10.1016/j.ajoms.2025.04.001

Yukiko Kusuyama , Rie Irie , Atsuko Niki-Yonekawa , Yoshio Ueno , Nobuo Morita , Yoshihiro Morita , Shinya Takahashi , Kenshin Ohara , Yumi Ito

Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is an Epstein-Barr virus-associated B-cell lymphoproliferative disorder that usually occurs in immunosuppressed patients. In this report, we describe the case of a 75-year-old man who repeatedly developed EBVMCUs at different gingival sites. He had a history of B-cell lymphoma and had achieved remission with chemotherapy 2 years before visiting our hospital. In all three EBVMCUs, radiographic examination revealed alveolar bone resorption beneath the EBVMCUs, and the ulcers regressed after spontaneous loss or extraction of adjacent teeth. Four years after the third appearance, no new lesions emerged, and the periodontal disease was controlled. Histopathological features showed that ulcers in the first and third instances were classical Hodgkin lymphoma-like and that in the second instance was a diffuse large B-cell lymphoma-like EBVMCU. Programmed death-ligand 1 (PD-L1) expression was examined using a PD-L1 antibody (SP142); only the ulcer in the third instance was positive. This case suggests a possible association between EBVMCU and periodontitis and that the past history of chemotherapy can be a risk factor for systemic immunosuppression causing EBVMCU.

eb病毒阳性粘膜皮肤溃疡（EBVMCU）是一种与eb病毒相关的b细胞淋巴增殖性疾病，通常发生在免疫抑制患者中。在这个报告中，我们描述了一个75岁的男性在不同的牙龈部位反复发展ebvmcu的病例。患者既往有b细胞淋巴瘤病史，在来我院就诊前2年通过化疗获得缓解。在所有三个ebvmcu中，x线检查显示ebvmcu下的牙槽骨吸收，溃疡在自发脱落或拔出邻近牙齿后消退。第三次出现后4年未出现新的病变，牙周病得到控制。组织病理学特征显示，第一例和第三例溃疡为典型的霍奇金淋巴瘤样溃疡，第二例为弥漫性大b细胞淋巴瘤样EBVMCU。应用程序性死亡配体1 （PD-L1）抗体（SP142）检测PD-L1表达；只有第三例的溃疡是阳性的。该病例提示EBVMCU与牙周炎之间可能存在关联，并且既往化疗史可能是导致EBVMCU的全身免疫抑制的危险因素。

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引用次数: 0

A case of sclerosing odontogenic carcinoma of the mandible 下颌骨硬化性牙源性癌1例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-02-26 DOI: 10.1016/j.ajoms.2025.02.017

Akinobu Shibata , Eri Yumoto , Hironori Sakai , Hiroshi Kurita

Sclerosing odontogenic carcinoma (SOC), a rare tumor first described in 2008, was incorporated into the World Health Organization (WHO) classification of odontogenic carcinomas in 2017. We present a case of SOC in the mandible. A 45-year-old female patient presented with pain in the right lower jaw and was referred to our hospital. The patient exhibited facial symmetry, with reduced sensitivity in the right lower lip and right side of the tongue. A smooth-surfaced soft mass (22 × 13 mm) was observed on the marginal gingiva surrounding first and second molars in the right mandible. A mass was identified in the region extending from the right mandibular first molar to the right mandibular ramus. CT imaging revealed cortical bone destruction on both the vestibular and lingual aspects in this region and a mass measuring 42 × 37 × 20 mm. SOC or odontogenic fibroma was suspected based on the biopsy findings. A right submandibular lymph node biopsy, segmental mandibular resection, and reconstruction using a free fibular flap were performed. Intraoperative pathological examination revealed no cervical lymph node metastasis, and neck dissection was not performed. Based on the resected specimen, a definitive diagnosis of SOC was established. 22 months post-surgery, no recurrence or metastasis has been observed.

硬化性牙源性癌（SOC）是一种罕见的肿瘤，于2008年首次被描述，于2017年被纳入世界卫生组织（WHO）的牙源性癌分类。我们报告一个下颌骨的SOC病例。一名45岁女性患者，因右下颚疼痛而被转介至我院。患者表现出面部对称，右下唇和舌右侧敏感性降低。右下颌骨第一、第二磨牙周围龈缘有一光滑软块（22 × 13 mm）。在右下颌第一磨牙至右下颌支的区域发现肿块。CT成像显示该区域前庭和舌侧皮质骨破坏，肿块大小为42 × 37 × 20 mm。根据活检结果，怀疑为SOC或牙源性纤维瘤。右下颌骨淋巴结活检，下颌骨节段性切除，重建使用游离腓骨皮瓣。术中病理检查未见颈部淋巴结转移，未行颈部清扫术。根据切除的标本，确定了SOC的明确诊断。术后22个月未见复发或转移。

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引用次数: 0

A case of primary squamous cell carcinoma of the submandibular gland responding to chemoradiotherapy 原发性颌下腺鳞状细胞癌放化疗的疗效分析

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-04-16 DOI: 10.1016/j.ajoms.2025.04.006

Akihiko Nakamura , Tomohiro Hamada , Mizuki Yanagida , Toshiaki Tanaka , Masashi Oe , Tsuguo Sano

Primary squamous cell carcinoma of the submandibular gland is extremely rare. Although surgical resection is recommended for the initial treatment of primary squamous cell carcinoma of the submandibular gland, postoperative loss of oral and maxillofacial function with tumor growth represents a significant concern. We report the case of a patient with primary squamous cell carcinoma of the submandibular gland that responded to chemoradiotherapy. A 72-year-old man was referred to our department with swelling in the right submandibular region. Tissue biopsy resulted in a histopathological diagnosis of squamous cell carcinoma. The patient declined surgery and selected chemoradiotherapy, which proved effective. However, salvage surgery was performed for residual tumor at the primary site. Negative results were obtained for CRTC1/MAML2 fusion, so the diagnosis was primary squamous cell carcinoma of the submandibular gland. Careful follow-up is important because patients with primary squamous cell carcinoma of the submandibular gland has a poor prognosis.

原发性颌下腺鳞状细胞癌极为罕见。虽然手术切除被推荐用于原发性颌下腺鳞状细胞癌的初始治疗，但术后肿瘤生长导致的口腔颌面功能丧失是一个值得关注的问题。我们报告的情况下，病人原发性鳞状细胞癌的下颌骨腺，响应放化疗。一名72岁男性因右下颌下区肿胀而转介至我科。组织活检导致组织病理学诊断为鳞状细胞癌。病人拒绝手术，选择放化疗，证明是有效的。然而，对原发部位的残余肿瘤进行了挽救性手术。CRTC1/MAML2融合阴性，诊断为原发性颌下腺鳞状细胞癌。仔细的随访是很重要的，因为原发性颌下腺鳞状细胞癌患者预后不良。

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引用次数: 0

Development of a surgical ciliated cyst after maxillary sinus floor augmentation for dental implants: A case report and review of the literature 上颌窦底增强术治疗种植牙后发生纤毛囊肿：一例报告及文献回顾

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-04-11 DOI: 10.1016/j.ajoms.2025.04.002

Hiroyuki Kano , Yusuke Kato , Satoko Fukui , Satoshi Maruyama , Tadaharu Kobayashi

The occurrence of s surgical ciliated cyst after maxillary sinus floor augmentation has been reported as a delayed and rare complication, although maxillary sinus floor augmentation is a proven and reliable technique for dental implants with a low incidence of postoperative complications. Here, we present a case of surgical ciliated cyst associated with maxillary sinus floor augmentation. A 71-year-old woman was referred to our clinic with a chief complaint of swelling and tenderness of the left palatal region. She had a history of dental implant treatment in the area at another clinic three years ago. Computerized tomography revealed a radiolucent area around the implant fixtures in the left upper molar region. Based on a clinical diagnosis of a maxillary cyst, the patient underwent enucleation of the cyst under general anesthesia. Histopathological findings of the surgical specimen revealed that the cyst was lined by nonkeratinized squamous epithelium and partially lined by ciliated pseudostratified columnar epithelium, and the cyst was ultimately diagnosed as a surgical ciliated cyst. In conclusion, the occurrence of a surgical ciliated cyst should be noted as a delayed complication of maxillary sinus floor augmentation, although its occurrence is extremely rare. To prevent the development of this cystic lesion, careful dissection of the maxillary sinus membrane from the bony surface is essential during maxillary sinus floor augmentation to minimize its damage and avoid its perforation.

虽然上颌窦底增强术是一种可靠的种植牙技术，术后并发症发生率低，但上颌窦底增强术后发生的手术纤毛囊肿是一种延迟且罕见的并发症。在此，我们报告一例手术睫状体囊肿合并上颌窦底增强术。一位71岁的妇女被转介到我们的诊所，主诉肿胀和压痛的左腭区域。三年前，她曾在该地区的另一家诊所接受过植牙治疗。计算机断层扫描显示在左侧上磨牙区种植固定体周围有一个透光区。根据上颌囊肿的临床诊断，患者在全身麻醉下接受了囊肿摘除手术。手术标本的组织病理学结果显示，囊肿内衬为非角化的鳞状上皮，部分内衬为纤毛假层状柱状上皮，最终诊断为手术纤毛囊肿。总之，手术纤毛囊肿的发生应被视为上颌窦底提升术的延迟并发症，尽管其发生极为罕见。为了防止这种囊性病变的发展，在上颌窦底增强术中，必须小心地从骨表面剥离上颌窦膜，以尽量减少其损伤并避免其穿孔。

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引用次数: 0

Malignant transformation of ameloblastoma: A case report and literature review 成釉细胞瘤恶性转化1例并文献复习

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology

Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.1016/j.ajoms.2025.03.003

Jiayi Wang , Baican Wang , Jiahui Dai , Yanli Wang , Ling Bi , Yangxi Cheng , Xirui Wang , Huiyong Zhu

Ameloblastic carcinoma is an odontogenic malignancy that is divided into a primary type called de novo cancer and a secondary type, a malignant transformation of an existing benign ameloblastoma. Most reported cases of ameloblastic carcinoma occur de novo, while few are caused by malignant degeneration of benign ameloblastoma. This study reports a case of mandibular secondary type ameloblastic carcinoma with malignant transformation 2 months after primary surgery. The patient received extended resection and postoperative radiotherapy. Eight months after operation, the skin flap had good color and soft texture, and the mandibular movement function and facial shape recovered well. We also reviewed 32 cases of secondary type ameloblastic carcinoma and analyzed the clinical features, treatment and results, suggesting that clinicians should pay attention to the possibility of malignant transformation of ameloblastoma and provide guidance for its treatment.

成釉细胞癌是一种牙源性恶性肿瘤，分为原发型（新生癌）和继发型（良性成釉细胞瘤的恶性转化）。大多数报告的成釉细胞癌是新生的，而少数是由良性成釉细胞瘤的恶性变性引起的。本研究报告一例下颌骨继发性成釉细胞癌在初次手术后2个月发生恶性转化。患者接受了扩大切除和术后放疗。术后8个月皮瓣颜色好，质地柔软，下颌骨运动功能和颜面形态恢复良好。我们还回顾了32例继发性成釉细胞癌的临床特点、治疗方法和结果，提示临床医生应重视成釉细胞瘤恶性转化的可能性，并对其治疗提供指导。

引用次数: 0