Canalicular adenoma (CA) is a rare, benign salivary gland tumor accounting for less than 1 % of all salivary gland tumors and 4–6 % of minor salivary gland tumors. We report a case of CA in the palate that was initially suspected to be malignant owing to the appearance of the lesion surface following a laser incision performed at another hospital. A 58-year-old woman presented with swelling of the palatal mucosa in the right maxillary molar area. Computed tomography and magnetic resonance imaging revealed a soft tissue mass; however, because the patient had a history of asthma and non-contrast imaging was selected for these imaging tests, the imaging findings did not differentiate between benign and malignant tumors. A diagnosis of CA was made based on hematoxylin and eosin staining and immunohistochemistry of the biopsy sample. The lesion was surgically removed from the palatal mucosa under general anesthesia. At the 12-month postoperative follow-up, the patient exhibited good healing with no evidence of recurrence.
{"title":"A case of palatal canalicular adenoma","authors":"Hitomi Kajikawa , Yoshihiro Morita , Kaori Oya , Ryotaro Kakimoto , Sho Katsura , Emiko Ogasa , Yukiko Kitahira , Yuka Matsumiya-Matsumoto , Akinori Takeshita , Narikazu Uzawa","doi":"10.1016/j.ajoms.2025.07.009","DOIUrl":"10.1016/j.ajoms.2025.07.009","url":null,"abstract":"<div><div>Canalicular adenoma (CA) is a rare, benign salivary gland tumor accounting for less than 1 % of all salivary gland tumors and 4–6 % of minor salivary gland tumors. We report a case of CA in the palate that was initially suspected to be malignant owing to the appearance of the lesion surface following a laser incision performed at another hospital. A 58-year-old woman presented with swelling of the palatal mucosa in the right maxillary molar area. Computed tomography and magnetic resonance imaging revealed a soft tissue mass; however, because the patient had a history of asthma and non-contrast imaging was selected for these imaging tests, the imaging findings did not differentiate between benign and malignant tumors. A diagnosis of CA was made based on hematoxylin and eosin staining and immunohistochemistry of the biopsy sample. The lesion was surgically removed from the palatal mucosa under general anesthesia. At the 12-month postoperative follow-up, the patient exhibited good healing with no evidence of recurrence.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 183-186"},"PeriodicalIF":0.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by hyperphosphaturia and hypophosphatemia, leading to impaired mineralization and dysplasia of bones and dentin. A 19-year-old man with XLH was referred to our department for diagnosis and treatment of radiolucent lesions in the maxilla and mandible. Panoramic radiography revealed enlarged pulp chambers, thin dentin, wide root canals, and root apex enlargement in all teeth, as characteristic features of XLH, as well as multiple radiolucent lesions involving the roots of teeth in the maxilla and mandible. A biopsy confirmed the diagnosis of radicular cyst. Subsequently, 11 teeth were extracted, and seven cysts were surgically enucleated under general anesthesia. Histopathological examination confirmed the diagnosis of radicular cysts for all seven cysts. Examination of decalcified sections of the extracted left maxillary lateral incisor revealed interglobular dentin, indicating marked dentin hypocalcification. Postoperatively, the patient has remained stable and continues to receive regular dental care at his primary dental clinic. Since XLH is associated with pulpal infection and internal dental fistula formation even in the absence of caries or trauma, close collaboration between dentists and physicians managing patients with XLH is essential from early childhood. Without appropriate oral management, XLH patients can develop apical periodontitis and radicular cysts that require surgical intervention, as observed in the present case.
{"title":"X-linked hypophosphatemia with multiple radicular cysts: a case report","authors":"Katsuhiko Hayashi, Takeshi Takayama, Katsuhito Watanabe, Yuki Sugiyama, Yuri Kirihara","doi":"10.1016/j.ajoms.2025.07.007","DOIUrl":"10.1016/j.ajoms.2025.07.007","url":null,"abstract":"<div><div>X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by hyperphosphaturia and hypophosphatemia, leading to impaired mineralization and dysplasia of bones and dentin. A 19-year-old man with XLH was referred to our department for diagnosis and treatment of radiolucent lesions in the maxilla and mandible. Panoramic radiography revealed enlarged pulp chambers, thin dentin, wide root canals, and root apex enlargement in all teeth, as characteristic features of XLH, as well as multiple radiolucent lesions involving the roots of teeth in the maxilla and mandible. A biopsy confirmed the diagnosis of radicular cyst. Subsequently, 11 teeth were extracted, and seven cysts were surgically enucleated under general anesthesia. Histopathological examination confirmed the diagnosis of radicular cysts for all seven cysts. Examination of decalcified sections of the extracted left maxillary lateral incisor revealed interglobular dentin, indicating marked dentin hypocalcification. Postoperatively, the patient has remained stable and continues to receive regular dental care at his primary dental clinic. Since XLH is associated with pulpal infection and internal dental fistula formation even in the absence of caries or trauma, close collaboration between dentists and physicians managing patients with XLH is essential from early childhood. Without appropriate oral management, XLH patients can develop apical periodontitis and radicular cysts that require surgical intervention, as observed in the present case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 179-182"},"PeriodicalIF":0.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm. SP comprises 0.4–1.2 % of minor salivary grand tumors. Age at diagnosis peaked in 60 s and an average age of 56.4 years. SP cases are somewhat more common in males(female/male=1:1.5). Herein, we present a rare case of a SP occurred in 80 s female. The patient underwent surgical resection and had no regrowth 10 months later. Although regrowth of SPs is rare, there have been reports of regrowth or malignant transformation of them, so we will follow up carefully.
{"title":"A rare case of a Sialadenoma papilliferum occurred in 80s female","authors":"Moe Tominaga, Hirokazu Yutori, Masanori Masui, Suguru Ishida","doi":"10.1016/j.ajoms.2025.07.002","DOIUrl":"10.1016/j.ajoms.2025.07.002","url":null,"abstract":"<div><div>Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm. SP comprises 0.4–1.2 % of minor salivary grand tumors. Age at diagnosis peaked in 60 s and an average age of 56.4 years. SP cases are somewhat more common in males(female/male=1:1.5). Herein, we present a rare case of a SP occurred in 80 s female. The patient underwent surgical resection and had no regrowth 10 months later. Although regrowth of SPs is rare, there have been reports of regrowth or malignant transformation of them, so we will follow up carefully.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 169-173"},"PeriodicalIF":0.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chylothorax following neck dissection rarely occurs on the contralateral side and typically develops ipsilaterally or bilaterally. Herein, we report an unusual case of bilateral pleural effusion and right-sided chylothorax after left neck dissection in an 81-year-old man. The patient presented with contact pain on the left tongue edge, which was caused by an ill-defined 12 × 6 mm ulcerative lesion with induration. His medical history included polio, and preoperative tests showed restrictive ventilatory impairment. The patient was diagnosed with left-sided tongue cancer (squamous cell carcinoma, T2N1M0) and underwent partial left glossectomy, left neck dissection, and tracheostomy. Postoperatively, pale-yellow fluid draining from the neck suggested chyle leakage, prompting supraclavicular fossa compression. By the seventh day, the bilateral pleural effusion had caused respiratory failure, and the patient required positive-pressure ventilation. Tube feeding was replaced with central venous nutrition on the tenth day. Right chylothorax was confirmed on the eleventh day. Low-fat tube feeding was resumed on Day 27, without chylothorax recurrence. The etiology of the right-sided chylothorax after left neck dissection was attributed to increased intralymphatic pressure from thoracic duct ligation and neck compression, causing duct rupture and lymph fluid spreading to the thoracic cavity via the mediastinum. This case highlights the need for careful post-neck dissection management because of the risk of severe respiratory failure due to chyle leakage.
{"title":"Bilateral pleural effusion and right chylothorax after left cervical dissection: A case report","authors":"Kiyoshi Sakai , Satoshi Yamaguchi , Shiho Usui , Noriyuki Yamamoto , Hideharu Hibi","doi":"10.1016/j.ajoms.2025.06.013","DOIUrl":"10.1016/j.ajoms.2025.06.013","url":null,"abstract":"<div><div>Chylothorax following neck dissection rarely occurs on the contralateral side and typically develops ipsilaterally or bilaterally. Herein, we report an unusual case of bilateral pleural effusion and right-sided chylothorax after left neck dissection in an 81-year-old man. The patient presented with contact pain on the left tongue edge, which was caused by an ill-defined 12 × 6 mm ulcerative lesion with induration. His medical history included polio, and preoperative tests showed restrictive ventilatory impairment. The patient was diagnosed with left-sided tongue cancer (squamous cell carcinoma, T2N1M0) and underwent partial left glossectomy, left neck dissection, and tracheostomy. Postoperatively, pale-yellow fluid draining from the neck suggested chyle leakage, prompting supraclavicular fossa compression. By the seventh day, the bilateral pleural effusion had caused respiratory failure, and the patient required positive-pressure ventilation. Tube feeding was replaced with central venous nutrition on the tenth day. Right chylothorax was confirmed on the eleventh day. Low-fat tube feeding was resumed on Day 27, without chylothorax recurrence. The etiology of the right-sided chylothorax after left neck dissection was attributed to increased intralymphatic pressure from thoracic duct ligation and neck compression, causing duct rupture and lymph fluid spreading to the thoracic cavity via the mediastinum. This case highlights the need for careful post-neck dissection management because of the risk of severe respiratory failure due to chyle leakage.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 65-68"},"PeriodicalIF":0.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rhabdomyosarcoma is a malignant soft-tissue tumor of mesenchymal origin, that mainly occurs in children. The current World Health Organization classification recognizes four distinct subtypes of rhabdomyosarcoma based on clinicopathological and molecular genetic features. The sclerosing type is less common with no standard treatment. The prognosis of rhabdomyosarcoma in adults and in patients with sclerosing subtypes is poor. A 31-year-old woman was referred to our hospital because of swelling of the right cheek and trismus. Clinical examination revealed a maximum mouth opening of 10 mm, and an elastic hard mass was palpated under the right buccal mucosa. Contrast enhanced computed tomography revealed a well-defined mass, approximately 30 mm in size, with heterogeneous contrast effect, in the right infratemporal fossa with bone resorption. Magnetic resonance imaging revealed low signal intensity on T1-weighted images, a heterogeneous contrast effect, and partially high signal intensity on T2-weighted images. Histopathological examination of a biopsy specimen revealed sclerosing rhabdomyosarcoma. Clinical examination indicated that complete surgical resection was possible. Accordingly, tumor resection and latissimus dorsi flap reconstruction were performed, followed by postoperative chemoradiotherapy, comprising vincristine, actinomycin D, and cyclophosphamide therapy and radiation therapy (36 Gy/20 fractions). No recurrence or metastasis was observed 45 months after surgery.
{"title":"Sclerosing rhabdomyosarcoma of the infratemporal fossa in an adult: A favorable long-term outcome","authors":"Chikako Yura , Wataru Kakuguchi , Naohiro Ogawa , Daigo Matsuyama , Shin Ariga , Koichi Yasuda , Taku Maeda , Aya Yanagawa-Matsuda , Yuichi Ashikaga , Yoichi Ohiro","doi":"10.1016/j.ajoms.2025.07.006","DOIUrl":"10.1016/j.ajoms.2025.07.006","url":null,"abstract":"<div><div>Rhabdomyosarcoma is a malignant soft-tissue tumor of mesenchymal origin, that mainly occurs in children. The current World Health Organization classification recognizes four distinct subtypes of rhabdomyosarcoma based on clinicopathological and molecular genetic features. The sclerosing type is less common with no standard treatment. The prognosis of rhabdomyosarcoma in adults and in patients with sclerosing subtypes is poor. A 31-year-old woman was referred to our hospital because of swelling of the right cheek and trismus. Clinical examination revealed a maximum mouth opening of 10 mm, and an elastic hard mass was palpated under the right buccal mucosa. Contrast enhanced computed tomography revealed a well-defined mass, approximately 30 mm in size, with heterogeneous contrast effect, in the right infratemporal fossa with bone resorption. Magnetic resonance imaging revealed low signal intensity on T1-weighted images, a heterogeneous contrast effect, and partially high signal intensity on T2-weighted images. Histopathological examination of a biopsy specimen revealed sclerosing rhabdomyosarcoma. Clinical examination indicated that complete surgical resection was possible. Accordingly, tumor resection and latissimus dorsi flap reconstruction were performed, followed by postoperative chemoradiotherapy, comprising vincristine, actinomycin D, and cyclophosphamide therapy and radiation therapy (36 Gy/20 fractions). No recurrence or metastasis was observed 45 months after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 82-87"},"PeriodicalIF":0.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glomus tumor is a benign tumor developing from the glomus cells at the arteriovenous anastomosis. It most frequently occurs in the skin of the fingers and toes and in the nail beds, and rarely in the oral region. An 85-year-old female patient presented to our department with a chief complaint of swelling of her upper lip. She was aware of the mass, and requested further treatment upon gradual growth of the lesion. Clinical examination revealed the mass in the center of upper lip beneath the mucosa. The lesion was an elastic soft mass measuring 16 × 14 mm in size. The mass was smooth and dark purplish in color. Magnetic resonance imaging revealed the low signal intensity in the T1 weighted image and high signal intensity in the T2 image, and mixed high and low signals within the mass. Ultrasound imaging revealed a uniform mass with a clear border, abundant blood flow signals, and enhanced posterior echoes. Histopathology confirmed the diagnosis of a glomus tumor. Since few papers have reported on the imaging findings of glomus tumors, our case findings will aid in the diagnosis of glomus tumors.
{"title":"A rare case of glomus tumor arising from the center of the upper lip","authors":"Jun-ya Okamoto , Katsuhisa Sekido , Keishi Hanashiro , Michiko Okita , Masashi Harada , Yasushi Hariya","doi":"10.1016/j.ajoms.2025.07.005","DOIUrl":"10.1016/j.ajoms.2025.07.005","url":null,"abstract":"<div><div>Glomus tumor is a benign tumor developing from the glomus cells at the arteriovenous anastomosis. It most frequently occurs in the skin of the fingers and toes and in the nail beds, and rarely in the oral region. An 85-year-old female patient presented to our department with a chief complaint of swelling of her upper lip. She was aware of the mass, and requested further treatment upon gradual growth of the lesion. Clinical examination revealed the mass in the center of upper lip beneath the mucosa. The lesion was an elastic soft mass measuring 16 × 14 mm in size. The mass was smooth and dark purplish in color. Magnetic resonance imaging revealed the low signal intensity in the T1 weighted image and high signal intensity in the T2 image, and mixed high and low signals within the mass. Ultrasound imaging revealed a uniform mass with a clear border, abundant blood flow signals, and enhanced posterior echoes. Histopathology confirmed the diagnosis of a glomus tumor. Since few papers have reported on the imaging findings of glomus tumors, our case findings will aid in the diagnosis of glomus tumors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 174-178"},"PeriodicalIF":0.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-05DOI: 10.1016/j.ajoms.2025.06.015
Qiwei Zeng , Ming Sheng , Si Ouyang , Bin Liu
Objective
This study aims to determine whether inflammatory and nutritional indices are associated with the formation of salivary fistula or sialocele following parotid benign tumor resection.
Methods
Retrospective analysis of 373 parotid tumor resection patients evaluated preoperative inflammatory or nutritional indices for predicting postoperative salivary fistula or sialocele. Binary logistic regression identified independent risk factors to construct a nomogram.
Results
Salivary fistula or sialocele occurred in 115 patients, yielding an incidence rate of 30.8 %. Binary logistic regression analysis demonstrated that postoperative duration of drainage, HALP score (Hemoglobin-Albumin-Lymphocyte-Platelet score) ≥ 49.2, and PNI (Prognostic Nutritional Index) ≥ 52.68 served as protective factors against salivary fistula or sialocele formation. Conversely, smoking was identified as a risk factor for salivary fistula or sialocele development, with all P-values < 0.05. Conclusions: HALP score, PNI, smoking, and duration of drainage are independent predictors of the occurrence of salivary fistula or sialocele after parotid benign tumor resection. The nomogram incorporating the indicators mentioned above can serve as a reference for clinicians to assess the occurrence of salivary fistula or sialocele following parotid benign tumor resection.
{"title":"Influence of inflammatory and nutritional indices on post-parotidectomy salivary fistula or sialocele in benign tumors","authors":"Qiwei Zeng , Ming Sheng , Si Ouyang , Bin Liu","doi":"10.1016/j.ajoms.2025.06.015","DOIUrl":"10.1016/j.ajoms.2025.06.015","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to determine whether inflammatory and nutritional indices are associated with the formation of salivary fistula or sialocele following parotid benign tumor resection.</div></div><div><h3>Methods</h3><div>Retrospective analysis of 373 parotid tumor resection patients evaluated preoperative inflammatory or nutritional indices for predicting postoperative salivary fistula or sialocele. Binary logistic regression identified independent risk factors to construct a nomogram.</div></div><div><h3>Results</h3><div>Salivary fistula or sialocele occurred in 115 patients, yielding an incidence rate of 30.8 %. Binary logistic regression analysis demonstrated that postoperative duration of drainage, HALP score (Hemoglobin-Albumin-Lymphocyte-Platelet score) ≥ 49.2, and PNI (Prognostic Nutritional Index) ≥ 52.68 served as protective factors against salivary fistula or sialocele formation. Conversely, smoking was identified as a risk factor for salivary fistula or sialocele development, with all P-values < 0.05. Conclusions: HALP score, PNI, smoking, and duration of drainage are independent predictors of the occurrence of salivary fistula or sialocele after parotid benign tumor resection. The nomogram incorporating the indicators mentioned above can serve as a reference for clinicians to assess the occurrence of salivary fistula or sialocele following parotid benign tumor resection.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 36-42"},"PeriodicalIF":0.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bone has a natural self-healing ability through the interaction of osteoblasts and osteoclasts under physiological conditions. However, when defects exceed the critical size due to congenital anomalies, trauma, inflammation, periodontal diseases, tumor resection, or surgical interventions, alveolar bone regeneration becomes challenging. Autologous bone grafting is the gold standard for alveolar bone defects but has drawbacks such as donor site morbidity and infection risks. Allografts also pose challenges, including immune responses and limited bone formation. Tissue engineering presents an alternative, utilizing bioactive scaffolds, osteogenic cells, and growth factors to create a biomimetic environment that enhances regeneration. This review explores the fundamentals of tissue engineering and its application in bone reconstruction. It first discusses the key components of tissue engineering, including cells, scaffolds, and growth factors in bone tissue engineering. This is followed by an overview of their integration with recent advancements in 3D-printed scaffolds for alveolar bone regeneration.
{"title":"The fundamentals of tissue engineering in the process of alveolar bone regeneration","authors":"Shiva Shirazian , Naghmeh Bahrami , Jafar Ai , Mohamad Bayat , Abdolreza Mohamadnia , Amin Khajavi , Fatemeh Ghorbani Shemshadsara","doi":"10.1016/j.ajoms.2025.07.003","DOIUrl":"10.1016/j.ajoms.2025.07.003","url":null,"abstract":"<div><div>Bone has a natural self-healing ability through the interaction of osteoblasts and osteoclasts under physiological conditions. However, when defects exceed the critical size due to congenital anomalies, trauma, inflammation, periodontal diseases, tumor resection, or surgical interventions, alveolar bone regeneration becomes challenging. Autologous bone grafting is the gold standard for alveolar bone defects but has drawbacks such as donor site morbidity and infection risks. Allografts also pose challenges, including immune responses and limited bone formation. Tissue engineering presents an alternative, utilizing bioactive scaffolds, osteogenic cells, and growth factors to create a biomimetic environment that enhances regeneration. This review explores the fundamentals of tissue engineering and its application in bone reconstruction. It first discusses the key components of tissue engineering, including cells, scaffolds, and growth factors in bone tissue engineering. This is followed by an overview of their integration with recent advancements in 3D-printed scaffolds for alveolar bone regeneration.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 1-10"},"PeriodicalIF":0.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor that develops from pleomorphic adenoma (PA) and rarely occurs in the minor salivary glands. The malignant components are most frequently classified as adenocarcinoma not otherwise specified or salivary duct carcinoma. A search of the literature revealed only one previous report of myoepithelial carcinoma ex pleomorphic adenoma (MEC-exPA) in the upper lip. In this report, we present a second case. A 74-year-old man presented with a 15-year history of a mass in the left upper lip. The tumor was resected under general anesthesia. Histopathological examination of the resected specimen showed a biphasic composition with PA areas and malignant changes. The carcinoma comprised atypical myoepithelial cells expressing both myoepithelial and epithelial markers. Based on these findings supported by immunohistochemical results, the final diagnosis was MEC-exPA. No signs of recurrence or metastasis have been observed as of two years after surgery.
{"title":"Myoepithelial carcinoma ex pleomorphic adenoma of the upper lip: A case report and literature review","authors":"Satoshi Niwa, Hirotsugu Umeda, Kenichiro Uchida, Katsuaki Mishima","doi":"10.1016/j.ajoms.2025.07.004","DOIUrl":"10.1016/j.ajoms.2025.07.004","url":null,"abstract":"<div><div>Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor that develops from pleomorphic adenoma (PA) and rarely occurs in the minor salivary glands. The malignant components are most frequently classified as adenocarcinoma not otherwise specified or salivary duct carcinoma. A search of the literature revealed only one previous report of myoepithelial carcinoma ex pleomorphic adenoma (MEC-exPA) in the upper lip. In this report, we present a second case. A 74-year-old man presented with a 15-year history of a mass in the left upper lip. The tumor was resected under general anesthesia. Histopathological examination of the resected specimen showed a biphasic composition with PA areas and malignant changes. The carcinoma comprised atypical myoepithelial cells expressing both myoepithelial and epithelial markers. Based on these findings supported by immunohistochemical results, the final diagnosis was MEC-exPA. No signs of recurrence or metastasis have been observed as of two years after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 76-81"},"PeriodicalIF":0.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To perform a comprehensive analysis of the three-dimensional effects of Le Fort I osteotomy (LFI) on the nasolabial region in skeletal class III patients by evaluating the three-dimensional movement of the maxilla and assessing its relationship with three-dimensional changes in nasolabial soft tissues.
Methods
This retrospective study included 20 skeletal class III patients (8 men and 12 women; mean age: 25.0 ± 8.2 years) who underwent LFI using SuperFIXSORB-MX®. We investigated the correlation between maxillary movement and nasolabial soft tissue changes following LFI with detailed three-dimensional computed tomography by surface superimposition preoperatively (T0), 4 days postoperatively (T1), and 1 year postoperatively (T2). The “surgical maxillary movement” was evaluated by surface superimposition of virtual LFI segments at T0 and T1. The “soft tissue change” was evaluated by superimposing an unchanged cranial section of T0 and T2 and measuring the soft tissue reference points set on the soft tissue sections of T0 and T2.
Results
The upward movement of the pronasale and the anterior movement of the subnasale, labiale superior, and alare creases were significantly positively correlated with the anterior movement of point-A; only the labiale superior was significantly positively correlated with the upward movement of point-A. However, the external nasal morphology was not significantly correlated with the movement of point-A.
Conclusions
Using the preoperative virtual skull section as a reference enabled a highly detailed evaluation of maxillary movement and corresponding soft tissue changes. This method is expected to contribute to more effective surgical planning and improved patient informed consent.
目的通过评价上颌骨的三维运动及其与鼻唇区软组织三维变化的关系，综合分析Le Fort I型截骨术（LFI）对骨骼III类患者鼻唇区的三维效果。方法本回顾性研究纳入20例骨骼III级患者（8男12女，平均年龄：25.0 ± 8.2岁），均采用SuperFIXSORB-MX®进行LFI治疗。我们通过术前（T0）、术后4天（T1）和术后1年（T2）的详细三维计算机断层扫描（表面叠加）研究了LFI后上颌运动与鼻唇软组织变化的相关性。通过虚拟LFI节段在T0和T1的表面叠加来评估“手术上颌运动”。通过叠加T0和T2不变的颅骨切片，测量T0和T2软组织切片上设置的软组织参考点来评估“软组织改变”。结果鼻前、鼻下、唇上、鼻翼皱褶的前运动与a点的前运动呈显著正相关；只有上唇与a点的上移呈显著正相关。外鼻形态与a点运动无显著相关。结论术前虚拟颅骨切面作为参考，可以非常详细地评估上颌运动和相应的软组织变化。该方法有望有助于更有效的手术计划和改善患者知情同意。
{"title":"Three-dimensional correlation between maxillary movement and nasolabial soft tissue changes immediately and 1 year following Le Fort I osteotomy in skeletal class III patients: New insights into nasolabial changes after surgery","authors":"Shinsuke Yamamoto , Reiko Iwadate , Keigo Maeda , Naoki Taniike","doi":"10.1016/j.ajoms.2025.06.016","DOIUrl":"10.1016/j.ajoms.2025.06.016","url":null,"abstract":"<div><h3>Objective</h3><div>To perform a comprehensive analysis of the three-dimensional effects of Le Fort I osteotomy (LFI) on the nasolabial region in skeletal class III patients by evaluating the three-dimensional movement of the maxilla and assessing its relationship with three-dimensional changes in nasolabial soft tissues.</div></div><div><h3>Methods</h3><div>This retrospective study included 20 skeletal class III patients (8 men and 12 women; mean age: 25.0 ± 8.2 years) who underwent LFI using SuperFIXSORB-MX®. We investigated the correlation between maxillary movement and nasolabial soft tissue changes following LFI with detailed three-dimensional computed tomography by surface superimposition preoperatively (T0), 4 days postoperatively (T1), and 1 year postoperatively (T2). The “surgical maxillary movement” was evaluated by surface superimposition of virtual LFI segments at T0 and T1. The “soft tissue change” was evaluated by superimposing an unchanged cranial section of T0 and T2 and measuring the soft tissue reference points set on the soft tissue sections of T0 and T2.</div></div><div><h3>Results</h3><div>The upward movement of the pronasale and the anterior movement of the subnasale, labiale superior, and alare creases were significantly positively correlated with the anterior movement of point-A; only the labiale superior was significantly positively correlated with the upward movement of point-A. However, the external nasal morphology was not significantly correlated with the movement of point-A.</div></div><div><h3>Conclusions</h3><div>Using the preoperative virtual skull section as a reference enabled a highly detailed evaluation of maxillary movement and corresponding soft tissue changes. This method is expected to contribute to more effective surgical planning and improved patient informed consent.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 1","pages":"Pages 43-51"},"PeriodicalIF":0.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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