Squamous cell carcinoma (SCC) rarely arises from the epithelial lining of odontogenic cysts, and is referred to as primary intraosseous squamous cell carcinoma (PISCC), which mainly originates from long-standing odontogenic cysts. The incidence of malignant changes in odontogenic cysts is between 0.3 % and 3 %. Approximately 25 % of PISCC derived from odontogenic cysts had a dysplastic lining. The report aims to describe an unusual occurrence of dysplastic changes in the epithelial lining of an odontogenic cyst with keratinization that was primarily diagnosed as an odontogenic keratocyst.
{"title":"Dysplastic epithelial changes in an odontogenic cyst with keratinization: A rare occurrence","authors":"Alireza Pournabi , Zahra Zolfaghari Saravi , Naghi Abbaszadeh , Hossein Ghorbani","doi":"10.1016/j.ajoms.2025.05.015","DOIUrl":"10.1016/j.ajoms.2025.05.015","url":null,"abstract":"<div><div>Squamous cell carcinoma (SCC) rarely arises from the epithelial lining of odontogenic cysts<span><span>, and is referred to as primary intraosseous squamous cell carcinoma (PISCC), which mainly originates from long-standing odontogenic cysts. The incidence of malignant changes in odontogenic cysts is between 0.3 % and 3 %. Approximately 25 % of PISCC derived from odontogenic cysts had a dysplastic lining. The report aims to describe an unusual occurrence of dysplastic changes in the epithelial lining of an odontogenic cyst with keratinization that was primarily diagnosed as an </span>odontogenic keratocyst.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1309-1313"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Odontogenic infection is the most common cause of necrotizing fasciitis of the head and neck, and underlying diseases, time to surgery, and spread of inflammation to the mediastinum are significant prognostic factors. Among them, jugular vein thrombophlebitis due to spread of a primary infection via the cervical fascia or cervical lymphatic system is rare. Herein, we report a case of Lemierre’s syndrome (LS) as a complication of a severe odontogenic infection in a patient who refrained from medical examinations for several years.
A 43-year-old man was referred to our hospital with pain and swelling in the left mandible. Based on the clinical and imaging findings, the patient was diagnosed with acute osteomyelitis, complicated with cervical cellulitis and LS. Multiple external jugular vein thromboses and distant infections were observed. Surgical drainage, sequestrectomy for mandibular osteomyelitis, and tooth extraction were performed, and antibiotics were administered for 9 weeks. No evidence of infection was observed 1 year after surgery.
{"title":"Lemierre’s syndrome associated with acute osteomyelitis: A case report and review of the literature","authors":"Masahito Hara, Tomofumi Naruse, Ayaka Takemura, Keisuke Omori, Kota Morishita, Tomohiro Yamada","doi":"10.1016/j.ajoms.2025.05.014","DOIUrl":"10.1016/j.ajoms.2025.05.014","url":null,"abstract":"<div><div>Odontogenic infection is the most common cause of necrotizing fasciitis of the head and neck, and underlying diseases, time to surgery, and spread of inflammation to the mediastinum are significant prognostic factors. Among them, jugular vein thrombophlebitis due to spread of a primary infection via the cervical fascia or cervical lymphatic system is rare. Herein, we report a case of Lemierre’s syndrome (LS) as a complication of a severe odontogenic infection in a patient who refrained from medical examinations for several years.</div><div>A 43-year-old man was referred to our hospital with pain and swelling in the left mandible. Based on the clinical and imaging findings, the patient was diagnosed with acute osteomyelitis, complicated with cervical cellulitis and LS. Multiple external jugular vein thromboses and distant infections were observed. Surgical drainage, sequestrectomy for mandibular osteomyelitis, and tooth extraction were performed, and antibiotics were administered for 9 weeks. No evidence of infection was observed 1 year after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1263-1268"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-05-02DOI: 10.1016/j.ajoms.2025.05.002
Ayumi Yamamoto, Sho Ishida, Yasuo Hanazawa
Juvenile xanthogranuloma (JXG) is a rare non-Langerhans cell histiocytosis that typically presents as a self-limiting dermatological condition in young children, and oral mucosal involvement is exceedingly rare. We report the case of a 2-year-old boy, in whom a pink exophytic nodule gradually enlarged for 3 months and subsequently changed to an orange submucosal mass in approximately 1 month. Excisional biopsy was performed to obtain a definitive diagnosis. Histopathological examination revealed diffuse proliferation of foamy histiocytes and Touton giant cells within the lesion. Based on these results, the patient was diagnosed with JXG. Herein, we present an uncommon case of oral JXG to increase awareness about this lesion. The patient is currently healthy, and no recurrence has been observed 2 years after surgical excision.
{"title":"Juvenile xanthogranuloma of the tongue: A case report","authors":"Ayumi Yamamoto, Sho Ishida, Yasuo Hanazawa","doi":"10.1016/j.ajoms.2025.05.002","DOIUrl":"10.1016/j.ajoms.2025.05.002","url":null,"abstract":"<div><div><span>Juvenile xanthogranuloma<span> (JXG) is a rare non-Langerhans cell histiocytosis that typically presents as a self-limiting dermatological condition<span> in young children, and oral mucosal involvement is exceedingly rare. We report the case of a 2-year-old boy, in whom a pink exophytic nodule gradually enlarged for 3 months and subsequently changed to an orange submucosal mass in approximately 1 month. Excisional biopsy was performed to obtain a definitive diagnosis. Histopathological examination revealed diffuse proliferation of foamy </span></span></span>histiocytes and Touton giant cells within the lesion. Based on these results, the patient was diagnosed with JXG. Herein, we present an uncommon case of oral JXG to increase awareness about this lesion. The patient is currently healthy, and no recurrence has been observed 2 years after surgical excision.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1294-1298"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A retrospective study of 66 patients with oral squamous cell carcinoma was conducted, focusing on the outcomes and treatment-related adverse events of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia on metastatic lymph nodes.
Methods
The superficial temporal and occipital arteries were catheterized. The treatment consisted of superselective intra-arterial chemotherapy (docetaxel, 60 mg/m2; cisplatin, 150 mg/m2) and daily concurrent radiotherapy (60 Gy) combined with hyperthermia for 6 weeks. Hyperthermia was induced once or twice weekly for 50 min during chemoradiotherapy.
Results
The 3-year locoregional control and overall survival rates were 82 % and 78 %, respectively. Treatment-related adverse events included grade 3 and 4 oral mucositis in 97 % of patients, radiation dermatitis in 50 %, and grade 1 and 2 neck skin burns in 59 % of patients.
Conclusions
This combination therapy has led to good outcomes in patients with advanced oral cancer and lymph node metastases.
{"title":"Thermochemoradiation therapy using retrograde superselective intra-arterial infusion for patients with cervical lymph node metastases from advanced oral squamous cell carcinoma: A retrospective study of 66 cases","authors":"Toshiyuki Koizumi , Takashi Ohya , Masaki Iida , Yuichiro Hayashi , Senri Oguri , Toshinori Iwai , Mitomu Kioi , Kenji Mitsudo","doi":"10.1016/j.ajoms.2025.06.003","DOIUrl":"10.1016/j.ajoms.2025.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>A retrospective study of 66 patients with oral squamous cell carcinoma<span><span> was conducted, focusing on the outcomes and treatment-related adverse events of retrograde superselective intra-arterial </span>chemoradiotherapy<span> combined with hyperthermia on metastatic lymph nodes.</span></span></div></div><div><h3>Methods</h3><div><span>The superficial temporal and occipital arteries were catheterized. The treatment consisted of superselective intra-arterial chemotherapy (docetaxel, 60 mg/m</span><sup>2</sup><span>; cisplatin, 150 mg/m</span><sup>2</sup><span>) and daily concurrent radiotherapy (60 Gy) combined with hyperthermia for 6 weeks. Hyperthermia was induced once or twice weekly for 50 min during chemoradiotherapy.</span></div></div><div><h3>Results</h3><div>The 3-year locoregional control and overall survival<span><span> rates were 82 % and 78 %, respectively. Treatment-related adverse events included grade 3 and 4 oral mucositis in 97 % of patients, </span>radiation dermatitis in 50 %, and grade 1 and 2 neck skin burns in 59 % of patients.</span></div></div><div><h3>Conclusions</h3><div>This combination therapy has led to good outcomes in patients with advanced oral cancer and lymph node metastases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1196-1202"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-05-10DOI: 10.1016/j.ajoms.2025.04.003
S. Sowmya , R. Sangavi , Pradeep kumar yadalam
Objective
Forensic odontology is a field of dentistry that applies dental science to the legal system, examining and analyzing dental evidence in criminal investigations, civil litigation, and other legal proceedings. It plays a crucial role in determining the gender of individuals whose bones have been significantly deformed in a catastrophic event. Forensic dentists use morphological and genetic studies to determine an individual's gender, relying on sexual dimorphism and remnants. The mandible and gonial angle, formed by the lower mandible and ramus, aid in gender determination and age estimation. The study aimed to assess the comparison of neural networks and gradient boosting in the prediction of gender based on gonial angle measurements.
Methods
Two hundred CBCT and 200 OPG images were retrieved from Oral and Maxillofacial Radiology archives, involving 100 males and 100 females. Before evaluation, CBCT scans underwent manual reorientation for standardization. The coronal view was adjusted by aligning the software's vertical reference line with the median sagittal plane. The axial reconstruction line was aligned with the mandibular body. The sagittal reconstruction image thickness was increased to 35 millimeters, with two lines for demarcation of the Gonion point. After obtaining the dataset, outliers were removed and normalized, and data were split into 80 % percent and 20 % percent test data and subjected to gradient boosting and neural networks.
Result
The study compares Neural Networks' and gradient-boosting models' performance on a task, finding that the Neural Network outperformed the latter with an Area Under the Curve (AUC) of 0.922 and a higher F1 score (Harmonic mean of Precision and Recall).
Conclusion
The study demonstrates that the gonial angle, a mandibular measure, can accurately determine gender, with conventional statistical methods and machine learning models predicting it, but with limitations
目的法医牙医学是将牙科学应用于法律体系的一个领域，在刑事调查、民事诉讼和其他法律诉讼中检查和分析牙科学证据。它在确定在灾难性事件中骨骼严重变形的个体的性别方面起着至关重要的作用。法医牙医利用形态学和遗传学研究来确定一个人的性别，依靠两性二态性和残余物。由下颌骨和支组成的下颌骨和角角有助于确定性别和估计年龄。该研究旨在评估神经网络和梯度增强在基于卵形角测量的性别预测中的比较。方法从口腔颌面放射学档案中检索CBCT图像200张，OPG图像200张，男、女各100张。在评估之前，CBCT扫描进行了手动重新定位以标准化。通过将软件的垂直参考线与正中矢状面对齐来调整冠状视图。轴向重建线与下颌骨体对齐。矢状面重建图像厚度增加到35毫米，用两条线划分Gonion点。获得数据集后，对异常值进行去除和归一化处理，将数据分成80% % %和20% % %的测试数据，并进行梯度增强和神经网络处理。结果比较了神经网络和梯度增强模型在某一任务上的表现，发现神经网络的曲线下面积（AUC）为0.922，F1分数（Precision and Recall的调和平均值）更高，优于梯度增强模型。结论下颌角是下颌的一个测量指标，可以准确地判断性别，传统的统计方法和机器学习模型可以预测，但存在局限性
{"title":"Gradient boosting based prediction of gender based on gonial angle measurements","authors":"S. Sowmya , R. Sangavi , Pradeep kumar yadalam","doi":"10.1016/j.ajoms.2025.04.003","DOIUrl":"10.1016/j.ajoms.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>Forensic odontology is a field of dentistry that applies dental science to the legal system, examining and analyzing dental evidence in criminal investigations, civil litigation, and other legal proceedings. It plays a crucial role in determining the gender of individuals whose bones have been significantly deformed in a catastrophic event. Forensic dentists use morphological and genetic studies to determine an individual's gender, relying on sexual dimorphism and remnants. The mandible and gonial angle, formed by the lower mandible and ramus, aid in gender determination and age estimation. The study aimed to assess the comparison of neural networks and gradient boosting in the prediction of gender based on gonial angle measurements.</div></div><div><h3>Methods</h3><div>Two hundred CBCT and 200 OPG images were retrieved from Oral and Maxillofacial Radiology archives, involving 100 males and 100 females. Before evaluation, CBCT scans underwent manual reorientation for standardization. The coronal view was adjusted by aligning the software's vertical reference line with the median sagittal plane. The axial reconstruction line was aligned with the mandibular body. The sagittal reconstruction image thickness was increased to 35 millimeters, with two lines for demarcation of the Gonion point. After obtaining the dataset, outliers were removed and normalized, and data were split into 80 % percent and 20 % percent test data and subjected to gradient boosting and neural networks.</div></div><div><h3>Result</h3><div>The study compares Neural Networks' and gradient-boosting models' performance on a task, finding that the Neural Network outperformed the latter with an Area Under the Curve (AUC) of 0.922 and a higher F1 score (Harmonic mean of Precision and Recall).</div></div><div><h3>Conclusion</h3><div>The study demonstrates that the gonial angle, a mandibular measure, can accurately determine gender, with conventional statistical methods and machine learning models predicting it, but with limitations</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 921-928"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-02-14DOI: 10.1016/j.ajoms.2025.02.012
Carlos M. Ardila , Pradeep K. Yadalam
{"title":"Advancing the utility of ultrasound texture analysis for lymph node metastasis detection in oral cancer","authors":"Carlos M. Ardila , Pradeep K. Yadalam","doi":"10.1016/j.ajoms.2025.02.012","DOIUrl":"10.1016/j.ajoms.2025.02.012","url":null,"abstract":"","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1031-1032"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-04-18DOI: 10.1016/j.ajoms.2025.04.009
Hiroyuki Kano , Yusuke Kato , Naoyuki Sato , Mai Nozawa‑Kobayashi , Tadaharu Kobayashi
Pyostomatitis vegetans (PV) is a rare, benign, and chronic disorder of the oral mucosa characterized by the presence of multiple pustules with an erythematous base and is an unusual oral expression of inflammatory bowel disease, such as ulcerative colitis (UC) or Crohn’s disease. Herein, a case of successful treatment for PV associated with UC is described. A 62-year-old male exhibited numerous tiny pustules and shallow erosions fusing to form characteristic “snail track” appearances were noted extensively on the gingiva. He had been diagnosed with UC five years previously and had been treated with steroid suppositories and other medications. Histological examination of a biopsy specimen of the upper left gingiva revealed a diagnosis of PV. Treatment for PV and UC was initiated with ATM therapy in which three antibiotics (amoxicillin, tetracycline and metronidazole) should be co-administered simultaneously three times a day, for two weeks. Then, the patient administered prednisolone at 30 mg/day. Two weeks later, significant improvement of oral mucosal lesions was observed. Although prednisolone was reduced gradually to 5 mg⁄ day after that, the erosions and ulcers of the rectalmucosa were not found endoscopically four months after the administration of systemic corticosteroids. Thereafter, treatment and management of UC was continued by his attending gastroenterologist, and no recurrence of PV has been observed for more than five years after the PV was cured.PV may accompany or precede active UC despite the absence of intestinal symptoms and can be used as a good mucocutaneous sign to determine the occurrence of active UC at an early stage.
{"title":"Pyostomatitis vegetans associated with ulcerative colitis: A case report","authors":"Hiroyuki Kano , Yusuke Kato , Naoyuki Sato , Mai Nozawa‑Kobayashi , Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2025.04.009","DOIUrl":"10.1016/j.ajoms.2025.04.009","url":null,"abstract":"<div><div>Pyostomatitis vegetans (PV) is a rare, benign, and chronic disorder of the oral mucosa characterized by the presence of multiple pustules with an erythematous base and is an unusual oral expression of inflammatory bowel disease, such as ulcerative colitis (UC) or Crohn’s disease. Herein, a case of successful treatment for PV associated with UC is described. A 62-year-old male exhibited numerous tiny pustules and shallow erosions fusing to form characteristic “snail track” appearances were noted extensively on the gingiva. He had been diagnosed with UC five years previously and had been treated with steroid suppositories and other medications. Histological examination of a biopsy specimen of the upper left gingiva revealed a diagnosis of PV. Treatment for PV and UC was initiated with ATM therapy in which three antibiotics (amoxicillin, tetracycline and metronidazole) should be co-administered simultaneously three times a day, for two weeks. Then, the patient administered prednisolone at 30 mg/day. Two weeks later, significant improvement of oral mucosal lesions was observed. Although prednisolone was reduced gradually to 5 mg⁄ day after that, the erosions and ulcers of the rectalmucosa were not found endoscopically four months after the administration of systemic corticosteroids. Thereafter, treatment and management of UC was continued by his attending gastroenterologist, and no recurrence of PV has been observed for more than five years after the PV was cured.PV may accompany or precede active UC despite the absence of intestinal symptoms and can be used as a good mucocutaneous sign to determine the occurrence of active UC at an early stage.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1077-1080"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Myeloid sarcoma (MS) commonly occurs in various body parts and most frequently develops in patients with acute myeloid leukemia (AML). MS in the oral cavity under non-leukemic conditions is rare and may be challenging to diagnose. Herein, we report a case of MS that presented with initial symptoms in the oral cavity under non-leukemic conditions. A 41-year-old woman presented to our hospital with swelling of the right upper gingiva, buccal region, and neck. Although several biopsies of the oral cavity were performed, none confirmed MS. Since positron emission tomography-computed tomography showed abnormal fluorodeoxyglucose uptake in the breast, a breast biopsy was performed; MS diagnosis was accordingly made. Subsequently, the patient received chemotherapy but died 11 months after initiating primary treatment. This report shows that the initial symptoms of MS may appear in the oral cavity under non-leukemic conditions and confirming MS requires histopathological examination. However, many cases are misdiagnosed and their diagnoses delayed. Diagnostic and treatment delays can impact prognosis. Clinicians should consider biopsies of suspicious oral lesions to ensure early diagnosis.
{"title":"Myeloid sarcoma presenting initially in the oral cavity under non-leukemic conditions: A case report","authors":"Yuria Onishi , Takuma Watanabe , Takehiro Watanabe , Tatsuya Kawamura , Shu Inoue , Yoko Shirai","doi":"10.1016/j.ajoms.2025.03.001","DOIUrl":"10.1016/j.ajoms.2025.03.001","url":null,"abstract":"<div><div>Myeloid sarcoma (MS) commonly occurs in various body parts and most frequently develops in patients with acute myeloid leukemia (AML). MS in the oral cavity under non-leukemic conditions is rare and may be challenging to diagnose. Herein, we report a case of MS that presented with initial symptoms in the oral cavity under non-leukemic conditions. A 41-year-old woman presented to our hospital with swelling of the right upper gingiva, buccal region, and neck. Although several biopsies of the oral cavity were performed, none confirmed MS. Since positron emission tomography-computed tomography showed abnormal fluorodeoxyglucose uptake in the breast, a breast biopsy was performed; MS diagnosis was accordingly made. Subsequently, the patient received chemotherapy but died 11 months after initiating primary treatment. This report shows that the initial symptoms of MS may appear in the oral cavity under non-leukemic conditions and confirming MS requires histopathological examination. However, many cases are misdiagnosed and their diagnoses delayed. Diagnostic and treatment delays can impact prognosis. Clinicians should consider biopsies of suspicious oral lesions to ensure early diagnosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 994-999"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orthognathic surgery causes functional and esthetic changes that may affect patients’ quality of life (QOL) and cause psychological changes. This study evaluated the effects of orthognathic surgery on QOL, psychological changes, and postoperative satisfaction in patients with facial asymmetry based on assessments immediately before and after surgery.
Methods
Subjective and objective asymmetry in patients with facial asymmetry were examined. Data were prospectively collected using the Oral Health Impact Profile (OHIP), State-Trait Anxiety Inventory (STAI), and postoperative satisfaction questionnaire.
Results
A total of 132 participants were included in the study, with 100 (23 males and 77 females) and 32 participants in the jaw deformity and normal groups, respectively. Their ages ranged from 17 to 48 years (mean 25.4 years). Orthognathic surgery contributed to improved oral-related QOL and positive psychological changes but not to the level of normal occlusions during the observation period (P < 0.01). In addition, patients with facial asymmetry showed less improvement in oral-related QOL and fewer positive psychological changes in the postoperative period than those without facial asymmetry. Functional limitation (P < 0.01), psychological discomfort (P < 0.01), and psychological disability (P < 0.01) were significantly lower postoperatively in the asymmetry group. In particular, there was little tendency for improvement in patients with subjective facial asymmetry. STAI results showed that patients with facial asymmetry had less positive psychological changes (P = 0.7363).
Conclusions
Information on oral-related QOL, psychological changes, and postoperative satisfaction related to the impact on patients with facial asymmetry, can help oral surgeons gain a more detailed understanding of patients’ surgical expectations and contribute to patient satisfaction.
{"title":"Impact of orthognathic surgery on oral-related quality of life and psychological changes in patients with facial asymmetry: A study of the oral health impact profile (OHIP-14) and state-trait anxiety inventory (STAI)","authors":"Kenichiro Katsuno, Daigo Yoshiga, Yuki Mori, Hiroki Tsurushima, Osamu Sakaguchi, Taishi Ohtani, Izumi Yoshioka","doi":"10.1016/j.ajoms.2025.02.013","DOIUrl":"10.1016/j.ajoms.2025.02.013","url":null,"abstract":"<div><h3>Objective</h3><div>Orthognathic surgery causes functional and esthetic changes that may affect patients’ quality of life (QOL) and cause psychological changes. This study evaluated the effects of orthognathic surgery on QOL, psychological changes, and postoperative satisfaction in patients with facial asymmetry based on assessments immediately before and after surgery.</div></div><div><h3>Methods</h3><div>Subjective and objective asymmetry in patients with facial asymmetry were examined. Data were prospectively collected using the Oral Health Impact Profile (OHIP), State-Trait Anxiety Inventory (STAI), and postoperative satisfaction questionnaire.</div></div><div><h3>Results</h3><div>A total of 132 participants were included in the study, with 100 (23 males and 77 females) and 32 participants in the jaw deformity and normal groups, respectively. Their ages ranged from 17 to 48 years (mean 25.4 years). Orthognathic surgery contributed to improved oral-related QOL and positive psychological changes but not to the level of normal occlusions during the observation period (<em>P</em> < 0.01). In addition, patients with facial asymmetry showed less improvement in oral-related QOL and fewer positive psychological changes in the postoperative period than those without facial asymmetry. Functional limitation (<em>P</em> < 0.01), psychological discomfort (<em>P</em> < 0.01), and psychological disability (<em>P</em> < 0.01) were significantly lower postoperatively in the asymmetry group. In particular, there was little tendency for improvement in patients with subjective facial asymmetry. STAI results showed that patients with facial asymmetry had less positive psychological changes (<em>P</em> = 0.7363).</div></div><div><h3>Conclusions</h3><div>Information on oral-related QOL, psychological changes, and postoperative satisfaction related to the impact on patients with facial asymmetry, can help oral surgeons gain a more detailed understanding of patients’ surgical expectations and contribute to patient satisfaction.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 883-890"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-03-04DOI: 10.1016/j.ajoms.2025.02.021
Débora Frota Colares, Julliany Taverny Sousa, André Luis Alves Borges, Bárbara de Assis Araújo, José Sandro Pereira da Silva, Lélia Batista de Souza
Heterotopic gastrointestinal cyst (HGIC) is a rare congenital cyst that may result from the displacement of gastric mucosal cells into other regions of the gastrointestinal tract. Although uncommon in the oral cavity, HGICs can cause feeding, swallowing, phonation, and breathing difficulties and may clinically resemble other soft tissue lesions. In this paper, we present a new case of oral HGIC in an infant and provide update on the existing literature regarding this condition in pediatric patients, with a focus on its clinical and pathological features. A 6-month-old female presented with a painless nodule in the ventral surface of the tongue, present since birth. Fine needle aspiration yielded a saliva-like fluid, and a clinical diagnosis of mucocele was initially made, followed by excisional biopsy in hospital setting. Histopathological examination showed a cystic lesion lined with epithelium of varying morphology, with the cystic capsule displaying muscle tissue and glandular elements beneath the cystic wall. Thus, the diagnosis of oral HGIC was established. The patient remains under follow-up with no signs of recurrence. Given its predilection for infants, oral HGICs should be considered in the differential diagnosis of nodules on the ventral tongue and floor of the mouth in pediatric patients.
{"title":"Large oral heterotopic gastrointestinal cyst in a child: A case report and update","authors":"Débora Frota Colares, Julliany Taverny Sousa, André Luis Alves Borges, Bárbara de Assis Araújo, José Sandro Pereira da Silva, Lélia Batista de Souza","doi":"10.1016/j.ajoms.2025.02.021","DOIUrl":"10.1016/j.ajoms.2025.02.021","url":null,"abstract":"<div><div>Heterotopic gastrointestinal cyst (HGIC) is a rare congenital cyst that may result from the displacement of gastric mucosal cells into other regions of the gastrointestinal tract. Although uncommon in the oral cavity, HGICs can cause feeding, swallowing, phonation, and breathing difficulties and may clinically resemble other soft tissue lesions. In this paper, we present a new case of oral HGIC in an infant and provide update on the existing literature regarding this condition in pediatric patients, with a focus on its clinical and pathological features. A 6-month-old female presented with a painless nodule in the ventral surface of the tongue, present since birth. Fine needle aspiration yielded a saliva-like fluid, and a clinical diagnosis of mucocele was initially made, followed by excisional biopsy in hospital setting. Histopathological examination showed a cystic lesion lined with epithelium of varying morphology, with the cystic capsule displaying muscle tissue and glandular elements beneath the cystic wall. Thus, the diagnosis of oral HGIC was established. The patient remains under follow-up with no signs of recurrence. Given its predilection for infants, oral HGICs should be considered in the differential diagnosis of nodules on the ventral tongue and floor of the mouth in pediatric patients.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1137-1140"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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