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3D longitudinal changes in palatal morphology in growing subjects: A retrospective study 生长期受试者腭形态的三维纵向变化:一项回顾性研究
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-20 DOI: 10.1016/j.ortho.2025.101033
Judith Oropeza Araque , Marianne Saade , Srikant Natarajan , Bhoomi Kotak , Melih Motro , Goli Parsi

Introduction

The palate plays a crucial role in oral functions such as speech, breathing, and mastication. Understanding its development during growth is essential for diagnosis and treatment planning. This study aimed to assess changes in palatal depth, width, volume, and surface area at ages 8, 12, and 18.

Material and methods

This retrospective analysis of palatal characteristics was performed on dental casts obtained at 3 time points: 8, 12, and 18 years of age from untreated cases obtained from the Forsyth Twin Growth Study database collected from 1959–1975. The casts were scanned then eleven landmarks were plotted and a 3D analysis was performed to obtain the anterior and posterior widths and depths, surface area, and volume. Repeated measures ANOVA and posthoc Bonferroni's test were performed to evaluate the changes at different ages.

Results

Thirty subjects (16 females and 14 males) were included in this study. There was a statistically significant increase in volume and posterior depth among all age groups for both sexes. Surface area exhibited early growth from age 8 to 12 in males, plateauing after 12 years, while anterior depth significantly increased from ages 12 to 18 in both sexes. Anterior width grew significantly in females during the same period, with no significant changes in males. Posterior width showed a gradual increase with no significant difference between 8 and 12 years or 12 and 18 years.

Conclusions

There were consistent incremental changes in the palate's volume and posterior depth. The anterior width of the palate did not show consistent growth, as it only significantly increased dimensions from 12 to 18 years of age in females, whereas the surface area plateaued in males after 12 years, and posterior width changes were non-significant.
上颚在言语、呼吸和咀嚼等口腔功能中起着至关重要的作用。了解其在生长过程中的发展对诊断和治疗计划至关重要。本研究旨在评估8岁、12岁和18岁儿童腭深度、宽度、体积和表面积的变化。材料和方法本研究对1959-1975年收集的Forsyth双胞胎生长研究数据库中未经治疗的病例在3个时间点获得的牙模型进行了腭特征的回顾性分析:8岁、12岁和18岁。扫描铸型,绘制11个地标,并进行三维分析,以获得前后宽度和深度,表面积和体积。采用重复测量方差分析(ANOVA)和事后Bonferroni检验来评价不同年龄的变化。结果共纳入30例受试者,其中女性16例,男性14例。在所有年龄组中,男女的体积和后深度均有统计学意义的增加。男性在8岁至12岁时,表面面积呈现早期增长,12岁后趋于平稳,而在12岁至18岁期间,两性的前深度均显著增加。在同一时期,女性的前宽明显增加,而男性没有明显变化。后脉宽度在8 ~ 12岁、12 ~ 18岁间逐渐增加,差异无统计学意义。结论上颚体积和后腭深度有持续的增量变化。上颚前部宽度并没有持续的增长,因为女性在12 - 18岁时上颚的尺寸只显着增加,而男性上颚的表面积在12岁后趋于平稳,后腭宽度的变化不显著。
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引用次数: 0
Protraction of bilateral mandibular molars into the first molar extraction sites using long arm hooks with clear aligners of an adult Class II Division 2 with crowding: A case report 使用带清晰对准器的长臂钩将双侧下颌磨牙延伸至第一磨牙拔牙部位(成人II类2级):一例报告
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1016/j.ortho.2025.101029
Hio Cheng Ieong, Yang Cao, Chen Zhou, Weicai Wang
Protraction of mandibular bilateral second molars to substitute for the extracted first molars is challenging in clear aligner treatment due to biological and biomechanical limitations. This case report presents a 28-year old female patient with poor prognoses for the mandibular bilateral first molars, a mesially impacted mandibular left third molar, and crowding in both the upper and lower arches. After the extraction of mandibular bilateral first molars, long-distance mandibular molar protraction was achieved using clear aligners with a novel protraction appliance, “the long arm hook”. At the end of the treatment, a Class I canine and molar relationship and good root parallelism were achieved. The combination of long arm hooks and clear aligners has proven to be clinically effective for the protraction of mandibular molars, thereby expanding the scope of clear aligner treatment.
由于生物学和生物力学的限制,下颌双侧第二磨牙的延长以替代拔除的第一磨牙是清除矫正器治疗的挑战。这个病例报告了一个28岁的女性患者,下颌双侧第一磨牙,下颌近侧阻生左第三磨牙,上弓和下弓拥挤,预后不佳。下颌双侧第一磨牙拔除后,采用一种新型的“长臂钩”拔除器,采用清晰对准器实现下颌磨牙的长距离拔除。治疗结束时,获得了I级犬齿与磨牙关系和良好的根平行度。长臂钩与透明矫正器的结合在临床上对于下颌磨牙的拔除是有效的,从而扩大了透明矫正器的治疗范围。
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引用次数: 0
Mandibular molar protraction using round Australian wire and miniscrew anchorage with modified corticision in an adult with first molar loss: A case report 使用圆形澳洲金属丝和微型支抗结合改良皮质修复第一磨牙缺失的成人下颌磨牙:1例报告
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-06-12 DOI: 10.1016/j.ortho.2025.101032
Qingjuan Shi , Qinglian Zhang , Hong Zheng, Yi Wang
A 27-year-old adult female presented with the chief complaint of bilateral mandibular first molar absence and strongly preferred to use wisdom teeth rather than prosthetic replacements. Treatment was carried out using a round Australian wire fixed orthodontic technique. The second and third molars were mesially moved with a bilateral terminal helical loop combined with curved tip-back bends in Australian wire. Miniscrew anchorage was placed in the mandibular premolar area to assist in the protraction of the second and third molars. Additionally, a modified cortical drilling technique was employed to accelerate tooth movement. A neutral molar relationship was established while maintaining the patient's facial profile.
一位27岁的成年女性以双侧下颌第一磨牙缺失为主诉,强烈倾向于使用智齿而不是假体置换。使用圆形澳大利亚金属丝固定正畸技术进行治疗。第二磨牙和第三磨牙采用双侧末端螺旋环结合弯曲的澳大利亚金属丝近端移动。在下颌前磨牙区放置微型支抗,辅助第二、第三磨牙的拔除。此外,采用改良的皮质钻孔技术来加速牙齿的运动。在保持患者面部轮廓的同时,建立了中性磨牙关系。
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引用次数: 0
Three-dimensional assessment of mini-implant supported maxillary canine retraction with and without power arm in class II division 1 patients: A split-mouth randomized trial II类1级患者带或不带动力臂的微型种植体支持上颌犬齿牵开的三维评估:一项裂口随机试验
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-30 DOI: 10.1016/j.ortho.2025.101030
Anas Nedal Kassas, Ahmed Mohamed Kamel, Mohammad Hasan Mohammad, Maher Abd El-Salam Fouda, Mona Abdelaziz Montasser

Introduction

The primary objectives of this trial were to compare the mechanics of direct sliding (DS) and power arm sliding (PAS) methods for canine retraction in regard to the rate of retraction, rotation, and tipping. The secondary objectives included the evaluation of canine mobility, mini-implant stability, and pain.

Material and methods

This split-mouth study was conducted over a 12-month intervention period on young adult patients with Class II Division 1 malocclusion requiring extraction of the maxillary first premolars, recruited between July 2023 and January 2024. Retraction methods were randomly assigned to sides by coin toss. Closed coil springs applying 150 g retraction forces were stretched to the canine bracket hook on one side and the power arm on the contralateral side. Digital models were analysed to measure canine retraction rate, tipping, and rotation. Canine mobility and mini-implant stability were assessed with the periotest. The pain was evaluated using a visual analogue scale. Data were analysed using two-way mixed ANOVA, and intraclass correlation test. Blinding was only used during data analysis.

Results

Twenty patients (aged 18.35 ± 2.85) were included. The total retraction rate was greater in DS (4.42 ± 0.75 mm) compared to PAS (2.93 ± 0.56 mm) with P < 0.001. Tipping and rotation were significantly higher in DS compared to PAS with P < 0.001, P = 0.031, respectively. No statistically significant differences were observed between the 2 methods regarding mini-implant stability, and pain. However, canine mobility revealed a significant difference only during the first and second months (P = 0.005, P = 0.003, respectively) with higher periotest values recorded in the PAS group. No harm was observed during the trial.

Conclusions

The DS method resulted in a faster rate of retraction than the PAS method. However, the PAS method effectively reduced both tipping and rotation, facilitating a more controlled bodily movement during canine retraction.
Trial registration in Clinical-Trial.gov under identification number NCT06352996.
本试验的主要目的是比较直接滑动(DS)和动力臂滑动(PAS)方法在犬回缩、旋转和倾斜方面的力学性能。次要目标包括评估犬的活动能力,微型植入物的稳定性和疼痛。材料和方法该裂口研究在2023年7月至2024年1月期间招募了需要拔除上颌第一前磨牙的II类1类错颌年轻成年患者,干预期为12个月。通过抛硬币的方式随机分配收放方法。封闭的螺旋弹簧施加150g的收缩力拉伸到一侧的犬齿支架钩和对侧的动力臂。分析了数字模型来测量犬的缩回率,倾斜和旋转。用骨膜试验评估犬的活动能力和微型种植体的稳定性。使用视觉模拟量表评估疼痛。数据分析采用双向混合方差分析和类内相关检验。盲法仅在数据分析时使用。结果共纳入20例患者,年龄18.35±2.85岁。DS组的总缩回率(4.42±0.75 mm)高于PAS组(2.93±0.56 mm);0.001. 与PAS和P <相比,DS的倾斜和旋转显著高于PAS;0.001, P = 0.031。两种方法在微型种植体稳定性和疼痛方面无统计学差异。然而,犬的活动度仅在第1个月和第2个月有显著差异(P = 0.005, P = 0.003), PAS组的牙周炎值更高。在试验期间没有观察到任何伤害。结论DS法比PAS法的牵入速度快。然而,PAS方法有效地减少了倾斜和旋转,促进了犬在缩回过程中更可控的身体运动。在Clinical-Trial.gov注册试验,识别号为NCT06352996。
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引用次数: 0
Orthodontic tooth movement in alveolar bone augmentation area: A systematic review of animal studies 牙槽骨增强区正畸牙齿移动:动物研究的系统回顾
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-30 DOI: 10.1016/j.ortho.2025.101031
Si-Min Wang , Jia He , Wen-Yu Chuo , Lin Wu

Objectives

This systematic review aims to evaluate the optimal timing for orthodontic tooth movement (OTM) following alveolar bone augmentation, the types of alveolar bone graft materials used, and the associated animal models.

Material and methods

A systematic search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and grey literature databases, covering studies from January 1st, 2014, to November 30th, 2024. Studies addressing combined alveolar bone augmentation and OTM were selected, with outcomes such as OTM rate, bone formation, and root resorption assessed through imaging or histological methods. A control group was required in animal experiments. There were no language restrictions. Article screening and data extraction were performed independently by two reviewers. The SYRCLE risk-of-bias tool was used to evaluate study quality.

Results

Fourteen animal studies were included, with subjects comprising dogs, rats, mice, and rabbits. The graft materials predominantly consisted of allografts, xenografts, and alloplasts. The applied orthodontic force ranged from 10 g to 150 g, with OTM performed at intervals of 0 to 3 months. Methodologies included model measurements, imaging, and histological analyses.

Conclusion

OTM can be performed during the bone weaving stage, however, the use of alveolar bone grafts generally impedes OTM. Alloplasts are associated with less root resorption. Animal models should closely mirror human characteristics, considering factors such as sex, age, defect location and size, type of tooth movement, and force magnitude. Overall, the quality of the studies is suboptimal, and further well-designed animal and human studies are needed.
This systematic review has been registered with PROSPERO (CRD42025642198).
目的本系统综述旨在评价牙槽骨增强后正畸牙齿移动(OTM)的最佳时机、牙槽骨移植材料的类型以及相关的动物模型。材料与方法系统检索PubMed、Web of Science、Cochrane Library、Scopus和灰色文献数据库,涵盖2014年1月1日至2024年11月30日的研究。我们选择了结合牙槽骨增强和牙槽骨移植的研究,通过影像学或组织学方法评估牙槽骨移植率、骨形成和牙根吸收等结果。动物实验设对照组。没有语言限制。文章筛选和数据提取由两名审稿人独立完成。使用sycle偏倚风险工具评价研究质量。结果共纳入14项动物研究,实验对象包括狗、大鼠、小鼠和家兔。移植物材料主要包括同种异体移植物、异种移植物和同种异体。施加的正畸力从10克到150克不等,OTM每隔0到3个月进行一次。方法包括模型测量、成像和组织学分析。结论在骨编织阶段可以进行游离骨修复,但牙槽骨移植通常会阻碍游离骨修复。同种异体与较少的根吸收有关。动物模型应密切反映人类特征,考虑性别、年龄、缺陷位置和大小、牙齿运动类型和力大小等因素。总的来说,研究的质量是次优的,需要进一步精心设计的动物和人类研究。该系统评价已在普洛斯彼罗注册(CRD42025642198)。
{"title":"Orthodontic tooth movement in alveolar bone augmentation area: A systematic review of animal studies","authors":"Si-Min Wang ,&nbsp;Jia He ,&nbsp;Wen-Yu Chuo ,&nbsp;Lin Wu","doi":"10.1016/j.ortho.2025.101031","DOIUrl":"10.1016/j.ortho.2025.101031","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aims to evaluate the optimal timing for orthodontic tooth movement (OTM) following alveolar bone augmentation, the types of alveolar bone graft materials used, and the associated animal models.</div></div><div><h3>Material and methods</h3><div>A systematic search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and grey literature databases, covering studies from January 1st, 2014, to November 30th, 2024. Studies addressing combined alveolar bone augmentation and OTM were selected, with outcomes such as OTM rate, bone formation, and root resorption assessed through imaging or histological methods. A control group was required in animal experiments. There were no language restrictions. Article screening and data extraction were performed independently by two reviewers. The SYRCLE risk-of-bias tool was used to evaluate study quality.</div></div><div><h3>Results</h3><div>Fourteen animal studies were included, with subjects comprising dogs, rats, mice, and rabbits. The graft materials predominantly consisted of allografts, xenografts, and alloplasts. The applied orthodontic force ranged from 10<!--> <!-->g to 150<!--> <!-->g, with OTM performed at intervals of 0 to 3<!--> <!-->months. Methodologies included model measurements, imaging, and histological analyses.</div></div><div><h3>Conclusion</h3><div>OTM can be performed during the bone weaving stage, however, the use of alveolar bone grafts generally impedes OTM. Alloplasts are associated with less root resorption. Animal models should closely mirror human characteristics, considering factors such as sex, age, defect location and size, type of tooth movement, and force magnitude. Overall, the quality of the studies is suboptimal, and further well-designed animal and human studies are needed.</div><div>This systematic review has been registered with PROSPERO (CRD42025642198).</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101031"},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatibility of direct printed clear aligners: A systematic review of in vitro studies 直接印刷透明对准器的生物相容性:体外研究的系统回顾
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-28 DOI: 10.1016/j.ortho.2025.101028
Claire-Adeline Dantagnan , Sylvie Babajko , Ali Nassif , André Porporatti , Jean-Pierre Attal , Elisabeth Dursun , Jean-François Nguyen , Julia Bosco

Objective

Three-dimensional printing of aligners has gained in popularity as an alternative to thermoformed aligners. Only few studies evaluate the biological effects of these new materials. This systematic review aims to investigate the residual monomers leaching from direct printed clear aligners and their possible toxic effects.

Search methods

A search was conducted on several databases in accordance with PRISMA guidelines. In vitro, in vivo and clinical studies in English were included. The risk of bias of in vitro studies was assessed by QUIN Tool, for in vivo studies with the SYRCLE tool and for clinical studies with the RoB-2 tool.

Results

In all, 524 articles were initially identified and nine were included in the qualitative analysis. All the included studies were in vitro research with a moderate risk of bias. Seven studies were focused on cell toxicity and two on monomer release. Although mixed results are described, 3D printed aligners could present a slight cytotoxicity. Compared with thermoformed aligners, direct printed aligners had higher cytotoxicity levels. No estrogenic effects and no trace of Bisphenol A (BPA) release were detected from printed aligners when investigated but a leaching of Urethane Dimethacrylate (UDMA) have been reported in all studies. Post-curing was an important step to obtain satisfactory biocompatibility of printed aligners.

Conclusions

There is no consensus on the absence of cytotoxic effects of direct printed aligners but the release of some potentially active monomers including UDMA requires further investigations on long-term effects on patients’ health.
目的三维打印矫形器作为热成型矫形器的一种替代方法已经越来越受欢迎。只有少数研究评估了这些新材料的生物学效应。本系统综述旨在探讨直接印刷透明对准剂的残留单体浸出及其可能的毒性作用。检索方法按照PRISMA指南对几个数据库进行了检索。包括体外、体内和临床英文研究。体外研究的偏倚风险采用QUIN工具评估,体内研究采用sycle工具评估,临床研究采用rob2工具评估。结果共筛选到524篇文献,其中9篇纳入定性分析。所有纳入的研究均为具有中等偏倚风险的体外研究。其中7项研究关注细胞毒性,2项研究关注单体释放。虽然描述了不同的结果,但3D打印的对准器可能呈现轻微的细胞毒性。与热成型矫形剂相比,直接打印矫形剂具有更高的细胞毒性水平。在调查时,没有从印刷的校准器中检测到雌激素效应和双酚A (BPA)释放的痕迹,但在所有研究中都报告了二甲基丙烯酸乙酯(UDMA)的浸出。后固化是获得良好生物相容性的重要步骤。结论:对于直接打印的校正剂没有细胞毒性作用尚无共识,但包括UDMA在内的一些潜在活性单体的释放需要进一步研究对患者健康的长期影响。
{"title":"Biocompatibility of direct printed clear aligners: A systematic review of in vitro studies","authors":"Claire-Adeline Dantagnan ,&nbsp;Sylvie Babajko ,&nbsp;Ali Nassif ,&nbsp;André Porporatti ,&nbsp;Jean-Pierre Attal ,&nbsp;Elisabeth Dursun ,&nbsp;Jean-François Nguyen ,&nbsp;Julia Bosco","doi":"10.1016/j.ortho.2025.101028","DOIUrl":"10.1016/j.ortho.2025.101028","url":null,"abstract":"<div><h3>Objective</h3><div>Three-dimensional printing of aligners has gained in popularity as an alternative to thermoformed aligners. Only few studies evaluate the biological effects of these new materials. This systematic review aims to investigate the residual monomers leaching from direct printed clear aligners and their possible toxic effects.</div></div><div><h3>Search methods</h3><div>A search was conducted on several databases in accordance with PRISMA guidelines. In vitro, in vivo and clinical studies in English were included. The risk of bias of in vitro studies was assessed by QUIN Tool, for in vivo studies with the SYRCLE tool and for clinical studies with the RoB-2 tool.</div></div><div><h3>Results</h3><div>In all, 524 articles were initially identified and nine were included in the qualitative analysis. All the included studies were in vitro research with a moderate risk of bias. Seven studies were focused on cell toxicity and two on monomer release. Although mixed results are described, 3D printed aligners could present a slight cytotoxicity. Compared with thermoformed aligners, direct printed aligners had higher cytotoxicity levels. No estrogenic effects and no trace of Bisphenol A (BPA) release were detected from printed aligners when investigated but a leaching of Urethane Dimethacrylate (UDMA) have been reported in all studies. Post-curing was an important step to obtain satisfactory biocompatibility of printed aligners.</div></div><div><h3>Conclusions</h3><div>There is no consensus on the absence of cytotoxic effects of direct printed aligners but the release of some potentially active monomers including UDMA requires further investigations on long-term effects on patients’ health.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101028"},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandibular canal angle, length and curvature in the three facial growth patterns and their association with vertical dysplasia indicators in adult patients: A retrospective cross-sectional 2D cephalometric study 三种面部生长模式的下颌管角度、长度和曲率及其与成人患者垂直发育不良指标的关系:一项回顾性横断面头颅测量研究
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-22 DOI: 10.1016/j.ortho.2025.101026
Madhanraj Selvaraj, Piramanayagam Varshitha, Bhaskar Nivethitha, Balasubramanian Madhan

Objective

The study compared the cephalometric mandibular canal (MC) morphology in different facial growth patterns and its association with other common vertical dysplasia indicators (VDI).

Material and methods

Pretreatment lateral cephalograms of 111 individuals (18–40 years) were categorised as normodivergent (ND), hypodivergent (HypoD), and hyperdivergent (HyperD) growth patterns based on SNGoGn. The mandibular canal angle (MCA) and VDI were estimated using cephalometric software. The mandibular canal length (MCL) and mandibular canal curvature (MCC) were calculated using the B-spline curve fitting method. The statistical analyses included comparing the MC variables across the three growth patterns and assessing their correlations with other VDI. Linear models were used to evaluate the multivariate effects of growth pattern, age and sex on MC variables.

Results

The HyperD group showed the highest median MCA (150°) followed by ND (146°) and HypoD (141°), with all intergroup differences significant at P < 0.001. There was no statistically significant difference in the MCL between the groups (ND = 57 ± 4.3, HypoD = 58.2 ± 4.5, HyperD = 57.9 ± 5.1 mm). The MCC radius was higher in HyperD (44.9 ± 8.7 mm) than in ND (39.1 ± 11.7, P = 0.034) and HypoD group (38.7 ± 8.5 mm, P = 0.026), implying a less curved MC in HyperD group. The age and sex of the individual did not have any significant impact on the MC variables. While MCA demonstrated moderate to high correlation with many VDI, the other two were not correlated with most.

Conclusion

The mandibular canal angle and curvature are potential cephalometric indicators of facial growth patterns, with the former being more robust and practical for routine clinical applications.
目的比较不同面部生长模式的下颌管(MC)形态及其与其他常见垂直发育不良指标(VDI)的关系。材料和方法111例(18-40岁)的后处理侧位脑电图根据SNGoGn将其分为正常(ND)、低发散(HypoD)和高发散(HyperD)生长模式。应用头颅测量软件测量下颌管角(MCA)和VDI。采用b样条曲线拟合法计算下颌管长度(MCL)和下颌管曲率(MCC)。统计分析包括比较三种增长模式的MC变量,并评估它们与其他VDI的相关性。采用线性模型评价生长方式、年龄和性别对MC变量的多变量影响。结果HyperD组MCA中位值最高(150°),其次为ND(146°)和HypoD(141°),两组间P <差异均有统计学意义;0.001. 各组间MCL差异无统计学意义(ND = 57±4.3 mm, HypoD = 58.2±4.5 mm, HyperD = 57.9±5.1 mm)。HyperD组MCC半径(44.9±8.7 mm)高于ND组(39.1±11.7,P = 0.034)和HypoD组(38.7±8.5 mm, P = 0.026),表明HyperD组MCC弯曲程度较低。个体的年龄和性别对MC变量没有显著影响。虽然MCA与许多VDI表现出中度到高度的相关性,但其他两个与大多数VDI不相关。结论下颌管角度和弯曲度是潜在的面部生长模式的头侧测量指标,下颌管角度和弯曲度在常规临床应用中更为可靠和实用。
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引用次数: 0
Retention of pubertal cervical vertebral maturation stages in adults (20–45 years). Limitations of cervical vertebral maturation in growth status assessment: A cross-sectional study 保留成人(20-45岁)的青春期颈椎成熟阶段。颈椎成熟在生长状态评估中的局限性:一项横断面研究
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-20 DOI: 10.1016/j.ortho.2025.101027
Erum Amin , Sajid Ali , Rana Faiza , Marium Jamil , Qasim Khalid , Umar Hussain , Nikoloas Pandis

Objective

To evaluate the retention of pubertal cervical vertebral maturation (CVM) stages in adults and assess the association of vertical and sagittal skeletal patterns on this retention.

Methods

This cross-sectional study was conducted on pre-treatment records of 489 adult participants (286 females and 203 males) aged 20 to 45. Inclusion criteria were clear lateral cephalometric radiographs and the absence of systemic conditions or previous orthodontic treatment affecting skeletal maturation. Skeletal sagittal and vertical patterns were recorded. Associations between CVM stages and sex, skeletal sagittal, and vertical pattern were analysed using inverse probability weighting (IPW)-adjusted ordinal logistic regression for age.

Results

The mean age was 26.09 (4.84) years. CS4 was retained in 8.59% and CS5 in 19.63%. Age varied significantly across stages (P = 0.01) with participants in CS5 being older. A significant sex difference was observed (P = 0.01) with more males in CS6 and more females in CS5. Skeletal class was significantly associated with CVM stages (P = 0.001) with Class III subjects more likely to exhibit less mature CVM stages. However, the vertical pattern was not significantly associated with CVM stages (P = 0.63). Ordinal logistic regression showed that Class III participants had a significantly lower likelihood of attaining CS6 (OR = 0.30, 95% CI: 0.16–0.54, P < 0.001) while vertical pattern and sex were not significant predictors after age adjustment.

Conclusion

A higher proportion of adults did not attain the post-pubertal CVM stage, especially in Class III malocclusion, raising concerns about CVM's reliability. Multiple growth indicators in combination with physical appearance should be used for skeletal maturation assessment.
目的评价成人青春期颈椎成熟(CVM)阶段的保留,并评估垂直和矢状骨模式与这种保留的关系。方法对年龄在20 ~ 45岁之间的489名成人(女性286人,男性203人)的治疗前记录进行横断面研究。纳入标准为清晰的侧位头颅x线片,无系统性疾病或既往正畸治疗影响骨骼成熟。记录骨骼矢状和垂直模式。使用年龄的逆概率加权(IPW)调整有序逻辑回归分析CVM分期与性别、骨骼矢状和垂直模式之间的关系。结果患者平均年龄26.09(4.84)岁。CS4保留8.59%,CS5保留19.63%。年龄在各阶段差异显著(P = 0.01), CS5的参与者年龄较大。性别差异显著(P = 0.01), CS6雄性较多,CS5雌性较多。骨骼分类与CVM分期显著相关(P = 0.001), III类受试者更有可能表现出不太成熟的CVM分期。然而,垂直模式与CVM分期无显著相关性(P = 0.63)。有序逻辑回归显示,III类受试者达到CS6的可能性显著降低(OR = 0.30, 95% CI: 0.16-0.54, P <;0.001),而纵向模式和性别在年龄调整后无显著预测意义。结论成人未达到青春期后CVM阶段的比例较高,尤其是III类错颌畸形,值得关注CVM的可靠性。骨骼成熟度评估应结合多种生长指标和体格外观。
{"title":"Retention of pubertal cervical vertebral maturation stages in adults (20–45 years). Limitations of cervical vertebral maturation in growth status assessment: A cross-sectional study","authors":"Erum Amin ,&nbsp;Sajid Ali ,&nbsp;Rana Faiza ,&nbsp;Marium Jamil ,&nbsp;Qasim Khalid ,&nbsp;Umar Hussain ,&nbsp;Nikoloas Pandis","doi":"10.1016/j.ortho.2025.101027","DOIUrl":"10.1016/j.ortho.2025.101027","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the retention of pubertal cervical vertebral maturation (CVM) stages in adults and assess the association of vertical and sagittal skeletal patterns on this retention.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted on pre-treatment records of 489 adult participants (286 females and 203 males) aged 20 to 45. Inclusion criteria were clear lateral cephalometric radiographs and the absence of systemic conditions or previous orthodontic treatment affecting skeletal maturation. Skeletal sagittal and vertical patterns were recorded. Associations between CVM stages and sex, skeletal sagittal, and vertical pattern were analysed using inverse probability weighting (IPW)-adjusted ordinal logistic regression for age.</div></div><div><h3>Results</h3><div>The mean age was 26.09 (4.84) years. CS4 was retained in 8.59% and CS5 in 19.63%. Age varied significantly across stages (<em>P</em> <!-->=<!--> <!-->0.01) with participants in CS5 being older. A significant sex difference was observed (<em>P</em> <!-->=<!--> <!-->0.01) with more males in CS6 and more females in CS5. Skeletal class was significantly associated with CVM stages (<em>P</em> <!-->=<!--> <!-->0.001) with Class III subjects more likely to exhibit less mature CVM stages. However, the vertical pattern was not significantly associated with CVM stages (<em>P</em> <!-->=<!--> <!-->0.63). Ordinal logistic regression showed that Class III participants had a significantly lower likelihood of attaining CS6 (OR<!--> <!-->=<!--> <!-->0.30, 95% CI: 0.16–0.54, <em>P</em> <!-->&lt;<!--> <!-->0.001) while vertical pattern and sex were not significant predictors after age adjustment.</div></div><div><h3>Conclusion</h3><div>A higher proportion of adults did not attain the post-pubertal CVM stage, especially in Class III malocclusion, raising concerns about CVM's reliability. Multiple growth indicators in combination with physical appearance should be used for skeletal maturation assessment.</div></div>","PeriodicalId":45449,"journal":{"name":"International Orthodontics","volume":"23 4","pages":"Article 101027"},"PeriodicalIF":1.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in fixed orthodontic patients: A triple-blind, randomized controlled trial with 9-month follow-up 蜂胶、氟化物和益生菌漱口水对固定正畸患者变形链球菌和氧化应激的比较评价:一项随访9个月的三盲、随机对照试验
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-15 DOI: 10.1016/j.ortho.2025.101017
Praveen Chandrashekaraiah , Reshma Benzigar , Ramya Shivananjan , Selva Arockiam , Nithya Nandhini , Sangeetha Ulaganathan

Background

Fixed orthodontic appliances increase the risk of enamel demineralization due to plaque accumulation. While fluoride mouthwash is well established, propolis and probiotic formulations are emerging alternatives with antimicrobial and anti-inflammatory potential.

Aim

To compare the effects of propolis, fluoride, and probiotic mouthwashes on Streptococcus mutans levels and oxidative stress (8-OHdG) in patients undergoing fixed orthodontic treatment.

Materials and methods

Of 120 patients screened (March 2022–February 2023), 90 were randomized into three groups (n = 30 each): propolis, fluoride, and probiotic. S. mutans was quantified at baseline, 30 days, 3-, 6- and 9-months using Q-PCR. Salivary 8-OHdG was measured using ELISA. Dietary and oral hygiene behaviours were monitored through a mobile app, interviews and 24-hour dietary recalls.

Results

S. mutans levels (log10 CFU/mL) significantly decreased (P < 0.001) at 9 months: from 4.35 ± 0.45 to 0.89 ± 0.06 (propolis), 4.42 ± 0.49 to 2.74 ± 0.18 (fluoride), and 4.38 ± 0.50 to 3.21 ± 0.06 (probiotic). Ct values increased accordingly, confirming reduced bacterial load. Salivary 8-OHdG (ng/mL) declined significantly (P < 0.001): 3.8 ± 0.8 to 0.32 ± 0.14 (propolis), 3.9 ± 0.7 to 1.32 ± 0.18 (fluoride), 3.8 ± 0.6 to 2.42 ± 0.22 (probiotic).

Conclusion

Propolis mouthwash produced the greatest reductions likely due to the combined effect of standardized extract and essential oils added for taste. Fluoride remained effective for microbial control, while probiotics offered modest benefit. High compliance strengthened these findings. Further studies should isolate active components and assess long-term effects in broader settings.
背景:固定正畸矫治器由于牙菌斑的积累,会增加牙釉质脱矿的风险。虽然含氟漱口水已经很成熟,但蜂胶和益生菌制剂是具有抗菌和抗炎潜力的新兴替代品。目的比较蜂胶、氟化物和益生菌漱口水对固定正畸治疗患者变形链球菌水平和氧化应激(8-OHdG)的影响。材料与方法筛选120例患者(2022年3月- 2023年2月),90例随机分为蜂胶组、氟化物组和益生菌组,每组30例。采用Q-PCR在基线、30天、3个月、6个月和9个月对变形链球菌进行定量。采用ELISA法测定唾液8-OHdG。通过手机应用程序、访谈和24小时饮食回顾来监测饮食和口腔卫生行为。突变体水平(log10 CFU/mL)显著降低(P <;0.001):从4.35±0.45到0.89±0.06(蜂胶),从4.42±0.49到2.74±0.18(氟化物),从4.38±0.50到3.21±0.06(益生菌)。Ct值相应升高,证实细菌载量降低。唾液8-OHdG (ng/mL)显著下降(P <;0.001): 3.8±0.8,0.32±0.14(蜂胶),3.9±0.7,1.32±0.18(氟),3.8±0.6,2.42±0.22(益生菌)。结论蜂胶漱口水的减脂效果最大,可能是标准提取物和调味精油共同作用的结果。氟化物对微生物控制仍然有效,而益生菌则提供适度的益处。高依从性加强了这些发现。进一步的研究应分离出有效成分,并在更广泛的环境中评估长期效果。
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引用次数: 0
Accuracy of combining intraoral and facial scan in a single digital model of an orthodontic patient utilizing corresponding measurements on the model and on real photographs: A prospective cross-sectional study 利用模型和真实照片上的相应测量,在正畸患者的单个数字模型中结合口内和面部扫描的准确性:一项前瞻性横断面研究
IF 1.8 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-08 DOI: 10.1016/j.ortho.2025.101015
Michail Vasoglou , Ioanna Pouliezou , Konstantinos Apostolopoulos , Georgios Vasoglou

Objectives

To validate the accuracy of integration of intraoral scan to the facial scan acquired by the EM3D application, utilising the Blue Sky Plan 4 software, creating a digital model of an orthodontic patient, by comparing the same linear measurements on real photographs and images from the digital model of the patient.

Material and methods

Thirty patients (20 females and 10 males; age range 12–30 years) undergoing orthodontic treatment with fixed appliances were recruited in this prospective cross-sectional study from December 2024 to February 2025. Five facial landmarks were marked on each patient: Tragion right, Cheilion right and left, Subnasale and Pronasale. Intraoral scan and facial scan were performed at the same appointment. Facial scan was conducted using an iPhone 13 Pro with the EM3D face scanning application which utilizes the iPhone's TrueDepth camera technology while the patient was smiling. The STL (Stereolithography) and OBG (Object) files (acquired from intraoral and facial scan respectively) were combined in a digital model using the Blue Sky Plan 4 software. Lateral and frontal photographs of the patient's face, while smiling, were also acquired. Eight linear measurements (Tragion right – bracket #11, Tragion right – incisal #11, Cheilion right – #13, Cheilion left – #13, Subnasale – #11, Subnasale – #21, Pronasale – #11, Pronasale – #21) were digitally performed on the real and digital photographs of the patients using the facial landmarks and certain points on teeth and braces. Paired sample t-test and Wilcoxon signed-rank test were used for statistical analysis.

Results

Significantly statistical difference was detected only in one (Cheilion right – #13) measurement (P = 0.004).

Conclusion

Combining intraoral and facial scan using a special software provides a clinically useful digital model of an orthodontic patient for diagnosis, treatment planning and outcome assessment.
目的利用Blue Sky Plan 4软件创建正畸患者的数字模型,通过比较来自患者数字模型的真实照片和图像的相同线性测量值,验证EM3D应用程序获得的口腔内扫描与面部扫描整合的准确性。材料与方法30例患者(女性20例,男性10例;在这项前瞻性横断面研究中,从2024年12月至2025年2月招募了年龄在12-30岁之间接受固定矫治器正畸治疗的患者。在每个患者身上标记5个面部标志:右鼻梁、左鼻梁、鼻下和鼻前。口腔内扫描和面部扫描在同一时间进行。面部扫描是在患者微笑时使用带有EM3D面部扫描应用程序的iPhone 13 Pro进行的,该应用程序利用了iPhone的TrueDepth相机技术。使用Blue Sky Plan 4软件将STL (Stereolithography)和OBG (Object)文件(分别从口腔内和面部扫描获取)合并到一个数字模型中。研究人员还获取了患者微笑时的侧面和正面照片。使用面部标志和牙齿和牙套上的某些点,对患者的真实照片和数字照片进行了八次线性测量(右耳部-支架#11,右耳部-切牙#11,右耳部- 13,左耳部- 13,鼻下- 11,鼻下- 21,Pronasale - 11, Pronasale - 21)。采用配对样本t检验和Wilcoxon符号秩检验进行统计分析。结果只有一次(Cheilion right - #13)测量结果有显著统计学差异(P = 0.004)。结论口腔内扫描和面部扫描结合使用的特殊软件为正畸患者的诊断、治疗计划和结果评估提供了临床有用的数字模型。
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引用次数: 0
期刊
International Orthodontics
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