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Clinical Controversy Surrounding the Differential Diagnosis of Branchiogenic Carcinoma. 枝源性癌鉴别诊断的临床争议。
IF 0.6 Pub Date : 2022-09-16 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4582262
Alexander Karatzanis, Kleanthi Mylopotamitaki, Eleni Lagoudaki, Emmanuel Prokopakis, Sofia Agelaki

Clinical evaluation, differential diagnosis, and management of a neck mass constitute commonly encountered problems for the head and neck surgeon. An asymptomatic neck mass in adults may be the only clinical sign of head and neck cancer. A 50-year-old female patient presented with a painless, slowly enlarging, left lateral neck lump. Ultrasonography described a possible lymph node with cystic degeneration, and fine needle aspiration biopsy only detected atypical cells of squamous epithelium. An open biopsy under general anesthesia was performed. Histopathological findings suggested the diagnosis of lymph node infiltration by squamous cell carcinoma of an unknown primary site, but differential diagnosis also included branchiogenic carcinoma arising in a branchial cleft cyst. A diagnostic algorithm for metastatic squamous cell carcinoma of an unknown primary site was followed, including positron emission tomography with computed tomography. The patient underwent panendoscopy and bilateral tonsillectomy, and an ipsilateral p16 positive tonsillar squamous cell carcinoma was detected. Further appropriate management followed. The existence of true branchiogenic carcinoma is controversial. When such a diagnosis is contemplated, every effort should be made to detect a possible primary site. Branchiogenic carcinoma, if exists at all, remains a diagnosis of exclusion.

临床评估、鉴别诊断和颈部肿块的处理是头颈部外科医生经常遇到的问题。成人无症状颈部肿块可能是头颈癌的唯一临床征象。一个50岁的女性病人表现为无痛,缓慢扩大,左侧颈部肿块。超声检查显示可能有淋巴结伴囊性变性,细针穿刺活检仅检出鳞状上皮的非典型细胞。全麻下行开放性活检。组织病理学结果提示原发部位未知的鳞状细胞癌淋巴结浸润,但鉴别诊断也包括鳃裂囊肿引起的鳃裂癌。一个诊断算法转移鳞状细胞癌的未知原发部位遵循,包括正电子发射断层扫描与计算机断层扫描。患者接受了全内窥镜检查和双侧扁桃体切除术,发现同侧p16阳性扁桃体鳞状细胞癌。随后进行了进一步的适当管理。真正的枝源性癌的存在是有争议的。当考虑这样的诊断时,应尽一切努力发现可能的原发部位。如果存在支原性癌,仍然是一种排除性诊断。
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引用次数: 1
Unusual Cause of Persistent Epistaxis with Severe Anemia in a Child. 儿童重度贫血持续性鼻出血的不寻常原因。
IF 0.6 Pub Date : 2022-08-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8557755
Yilkal Zemene, Tadele Hailu, Josh Wiedermann

Epistaxis in children can be caused by different systemic and local pathologies. Respiratory infections, nasal mucosa dryness, and foreign bodies are some local causes of bleeding from the nose. In developing countries, infestations still contribute a significant proportion of anemia in children. But it is very unusual for leech-causing persistent epistaxis with a consequence of severe anemia. We herein report a rare cause of severe anemia in a 5-year-old child presented to our clinic for persistent epistaxis. A leech was taken out with forceps, and his anemia was treated accordingly.

儿童鼻出血可由不同的全身和局部病理引起。呼吸道感染、鼻黏膜干燥、异物等是引起鼻出血的局部原因。在发展中国家,感染仍然是造成儿童贫血的很大一部分原因。但它是非常罕见的水蛭引起的持续鼻出血与严重贫血的后果。我们在此报告一个罕见的原因严重贫血的5岁儿童提出了我们的诊所持续鼻出血。医生用镊子取出一条水蛭,并对他的贫血进行了相应的治疗。
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引用次数: 0
Disturbed Pitch Perception during Antidepressant Therapy of a Combination of Lithium, Nortriptyline, and Oxazepam: A Rare Unexpected and Undesirable Side Effect for a Violinist. 在锂、去甲替林和奥西泮联合抗抑郁治疗期间,音调感知受到干扰:对小提琴家来说,这是一种罕见的意想不到的不良副作用。
IF 0.6 Pub Date : 2022-07-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4494284
Siwert de Groot

Disturbed pitch perception is a rare but well-known side effect of the antiepileptic drug carbamazepine and its derivates. A patient is presented who used three antidepressants because of depression. After recovering, the medication was continued, but as a violinist, the patient was told that his intonation was too low with the consequence that he was not allowed to participate in the orchestra where he had been for years. After phasing out the medications, his pitch perception returned to normal. This observation is unique as no other examples of this side effect are found in the literature in relation to antidepressants.

音调感知障碍是抗癫痫药物卡马西平及其衍生物的一种罕见但众所周知的副作用。一个病人被提出谁使用三种抗抑郁药,因为抑郁症。康复后,继续服药,但作为一名小提琴手,病人被告知他的语调太低,结果他被禁止参加他已经参加了多年的管弦乐队。在逐步停用药物后,他的音高感知恢复了正常。这一观察是独特的,因为在文献中没有发现与抗抑郁药有关的其他副作用的例子。
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引用次数: 0
An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection. 一名18岁女性在轻度COVID-19感染期间出现单侧声带麻痹。
IF 0.6 Pub Date : 2022-07-08 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6059487
John M Coggins, Charisse Wright, Michael P Underbrink

The COVID-19 pandemic has shown with certainty that SARS-CoV-2 can cause a variety of clinical findings, with some of the most notable being lasting chemosensory changes. Severe infections with SARS-CoV-2 can also lead to a variety of complications. For example, vocal cord paralysis can be caused by trauma sustained during intubation, which is a necessary procedure for many severe cases. Rarely, SARS-CoV-2 related vocal cord paralysis has occurred outside the context of intubation. These cases contribute to an emerging assortment of evidence supporting the neuropathic capacity of SARS-CoV-2. This report documents a case of COVID-19 related vocal cord paralysis in an 18-year-old female. The patient had a significant history of muscle tension dysphonia, chronic laryngitis, and vocal cord nodules. The patient developed vocal cord paralysis concurrently with the onset of mild viral symptoms and was never intubated or hospitalized. Based on the onset of symptoms and other causes being excluded with CT, a diagnosis of COVID-19-related vocal cord paralysis was performed.

COVID-19大流行已经明确表明,SARS-CoV-2可引起各种临床症状,其中一些最显著的是持续的化学感觉变化。SARS-CoV-2的严重感染也会导致各种并发症。例如,在插管期间持续的创伤可能导致声带麻痹,这是许多严重病例的必要手术。SARS-CoV-2相关的声带麻痹很少在插管之外发生。这些病例为支持SARS-CoV-2的神经病变能力提供了新的证据。本报告记录了一例18岁女性COVID-19相关声带麻痹病例。患者有明显的肌肉紧张性发声障碍、慢性喉炎和声带结节病史。患者在出现轻微病毒症状的同时出现声带麻痹,从未插管或住院。根据症状的出现和CT排除的其他原因,诊断为covid -19相关声带麻痹。
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引用次数: 1
An Extremely Rare Cause of Isolated Congenital Anosmia. 孤立性先天性嗅觉缺失的一种极为罕见的病因。
IF 0.6 Pub Date : 2022-07-07 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9692716
Chia Saw, Noel David Friesen, Anthony Bartley

A 14-year-old adolescent was referred to a regional paediatric outpatient clinic with anosmia by her family doctor in Western Australia. The patient has no recollection of her previous ability to smell, suggesting the possibility of congenital anosmia. She was assessed in the paediatric outpatient clinic. A "noncontrast high-resolution MRI-brain scan with Anosmia-Protocol" was requested as the first-line investigation of choice by the treating paediatrician. The MRI was reported as "absence of olfactory tracts with preserved olfactory bulb volume." We report an extremely rare case of "isolated agenesis of the olfactory tract with intact olfactory bulbs" and discuss the clinical approach in bedside assessment of isolated congenital anosmia (ICA). Congenital anosmia can be a presentation of olfactory bulb aplasia; however, little is known about isolated olfactory tract agenesis and its treatment options. The patient was counselled on the diagnosis and safety advice provided.

在西澳大利亚,一名14岁的青少年被她的家庭医生转介到一家地区儿科门诊,患有嗅觉缺失症。病人不记得她以前的嗅觉能力,提示可能是先天性嗅觉缺失。她在儿科门诊接受了评估。“非对比高分辨率mri脑扫描与缺失协议”被要求作为一线调查的选择由治疗儿科医生。MRI报告为“嗅束缺失,嗅球体积保留”。我们报告一例极其罕见的“孤立性嗅道发育不全且嗅球完整”的病例,并讨论孤立性先天性嗅觉缺失(ICA)床边评估的临床方法。先天性嗅觉缺失可能是嗅球发育不全的表现;然而,人们对孤立性嗅道发育不全及其治疗方案知之甚少。向患者提供诊断和安全建议。
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引用次数: 0
A Case of Cervical Intraneural Lipoma That Was Removed by Intercapsular Resection with No Resultant Postoperative Neurological Deficit. 颈神经内脂肪瘤经囊间切除无术后神经功能缺损1例。
IF 0.6 Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4618731
Hitoshi Sato, Yoshiro Saito, Tatsuya Kitajima, Shunya Egawa, Toshikazu Shimane

Intraneural lipomas in peripheral nerves of cervical lesions are extremely rare and have not been previously reported. We present a 48-year-old male with a gradually increasing right cervical mass since 5 years. He visited our department because of pain and difficulty in raising the right upper limb. A tumor about 80 mm in size was palpable in the right neck along the cervical nerve. The tumor was suspected to involve fatty degeneration in schwannoma of cervical nerve origin, for which intercapsular resection was performed under general anesthesia. Histopathologically, bifurcated growth of mature adipocytes with sparse fibrous septa and lack of tumor proliferation of Schwann cells was observed on H&E staining, suggesting a diagnosis of intraneural lipoma. The patient had no new motor or sensory deficits postoperatively and with improvement in his preoperative symptoms.

神经内脂肪瘤在宫颈周围神经病变是极其罕见的,并没有以前的报道。我们报告一位48岁男性,5年来右侧宫颈肿块逐渐增大。他因右上肢抬起疼痛和困难而来我科就诊。右颈部沿颈神经可触及约80毫米大小的肿瘤。怀疑肿瘤涉及颈神经源神经鞘瘤脂肪变性,在全身麻醉下行包膜间切除术。组织病理学上,H&E染色见成熟脂肪细胞分叉生长,纤维间隔稀疏,雪旺细胞未见肿瘤增生,提示神经内脂肪瘤。患者术后无新的运动或感觉缺陷,术前症状有所改善。
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引用次数: 0
Dedifferentiated Leiomyosarcoma of the Auricle with Heterologous Osteosarcoma Component: Case Report and Literature Review 伴有异体骨肉瘤成分的耳廓去分化平滑肌肉瘤:1例报告及文献复习
IF 0.6 Pub Date : 2022-05-31 DOI: 10.1155/2022/3684461
Andrea Dekanić, N. Jonjić, Anita Savić Vuković
Leiomyosarcomas are rare malignant tumors of smooth muscles. Head and neck involvement by this disease is very rare, and cutaneous leiomoysarcomas of the ear are even rarer. This is way clinically they are usually mistaken for either squamous or basal cell carcinomas, as was the case in an 85-year-old male patient presented in this report. However, the final diagnosis was even more interesting considering that it was a dedifferentiated leiomyosarcoma of the auricle with a heterologous component of osteosarcoma. The auricular cutaneous malignancies have a much higher rate of recurrence than the corresponding malignancy in other regions of the head and neck, even when resected with negative surgical margins, and dedifferentiated leiomyosarcoma is clinically even more aggressive. Thus, the treatment of choice is a total auriculectomy and great attention should be paid to appropriate margins.
摘要平滑肌肉瘤是一种罕见的平滑肌恶性肿瘤。这种疾病累及头颈部非常罕见,耳皮肤平滑肌肉瘤更罕见。这是临床上常被误认为鳞状细胞癌或基底细胞癌的原因,正如本报告中一位85岁男性患者的病例。然而,最后的诊断更加有趣,因为这是一种耳廓去分化平滑肌肉瘤,伴有骨肉瘤的异源成分。耳廓皮肤恶性肿瘤的复发率远高于头颈部其他部位的相应恶性肿瘤,即使在手术切缘阴性的情况下也是如此,而去分化平滑肌肉瘤在临床上更具侵袭性。因此,治疗的选择是全耳切除术,并应注意适当的边缘。
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引用次数: 0
The Youngest Case of Metachronous Bilateral Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Literature Review 最年轻的双侧异时性腮腺腺泡细胞癌1例报告并文献复习
IF 0.6 Pub Date : 2022-05-24 DOI: 10.1155/2022/8474741
Raid Alhayaza, M. Dababo, S. Velagapudi
Introduction Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that represents 17% of all salivary gland malignancies. It has a tendency to affect young individuals, especially females. ACC mainly originates in the parotid gland and has a potential for recurrence and metastases. Rarely, ACC can affect both parotid glands in a single individual. A bilateral ACC of the parotid gland could either present as a synchronous or a metachronous tumor. Case Report. Our patient is a 19-year-old female known case of ACC of the right parotid gland. The tumor was resected in December 2017. After 3 years, she presented with a left parotid pain and swelling, which raised the suspicion of a contralateral metachronous tumor of the left parotid gland. In September 30, 2020 we proceeded with ultrasound-guided fine needle aspiration of the left intraparotid lesion, and the results turned out to be consistent with ACC. Here, we report a case of a 19-year-old female presenting with metachronous bilateral ACC of the parotid gland with an interval of 3 years, which is the 6th of its kind in the literature and the youngest amongst them. Conclusion Despite the rareness of metachronous occurrence of bilateral ACC of the parotid gland, it is still encountered in the medical practice. Here, we are highlighting the importance of follow-up with a periodic clinical and radiological examinations, bearing in mind the contralateral nonaffected parotid gland.
腺泡细胞癌(ACC)是一种低级别恶性涎腺肿瘤,占所有涎腺恶性肿瘤的17%。它倾向于影响年轻人,尤其是女性。ACC主要起源于腮腺,有复发和转移的可能。罕见的是,ACC可以同时影响一个人的两个腮腺。双侧腮腺ACC可表现为同步或异时性肿瘤。病例报告。我们的病人是一名19岁的女性,已知右腮腺ACC病例。该肿瘤于2017年12月切除。3年后,她出现左侧腮腺疼痛和肿胀,这引起了对侧左腮腺异时性肿瘤的怀疑。我们于2020年9月30日行超声引导下左侧腮腺内病变细针穿刺,结果与ACC一致。在此,我们报告一例19岁女性腮腺异时性双侧ACC,间隔3年,这是文献中第6例,也是其中最年轻的一例。结论腮腺双侧ACC异时性发生虽少见,但在医疗实践中仍会遇到。在这里,我们强调随访的重要性,定期临床和放射检查,记住对侧未受影响的腮腺。
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引用次数: 0
Frontal Balloon Sinuplasty in Complicated Acute Pediatric Rhinosinusitis (ARS) 额窦球囊成形术治疗小儿复杂急性鼻窦炎
IF 0.6 Pub Date : 2022-05-14 DOI: 10.1155/2022/7232588
Smrithi Chidambaram, B. Wahle, D. Leonard
Utilization of frontal balloon sinuplasty in pediatric complicated acute rhinosinusitis (ARS) is demonstrated to be a safe and expedient alternative to other procedures such as trephination or functional endoscopic sinus surgery (FESS) in this case series. We performed a retrospective review of six pediatric cases of frontal balloon sinuplasty for ARS with intracranial complications at a tertiary academic center. Patients underwent unilateral (n = 5) or bilateral dilation (n = 1) in addition to functional endoscopic sinus surgery (FESS) including anterior ethmoidectomy (n = 5) and maxillary antrostomy (n = 6). This technique effectively addressed frontal sinus obstruction and served as an alternative to procedures such as trephination or functional endoscopic sinus surgery. No immediate or short-term complications of balloon dilation were observed in these cases. A larger cohort and extended follow-up are necessary to determine the use and long-term impact of this technique.
在本病例系列中,使用额叶球囊鼻窦成形术治疗儿童复杂的急性鼻窦炎(ARS)被证明是一种安全、方便的替代方法,可以替代其他手术,如穿刺或功能性内窥镜鼻窦手术(FESS)。我们对在某三级学术中心接受额叶球囊窦成形术治疗ARS合并颅内并发症的6例患儿进行回顾性分析。患者接受单侧(n = 5)或双侧扩张(n = 1),以及功能性内窥镜鼻窦手术(FESS),包括前筛窦切除术(n = 5)和上颌窦口造口术(n = 6)。这项技术有效地解决了额窦阻塞,并作为其他手术的替代方案,如穿甲术或功能性内窥镜鼻窦手术。在这些病例中没有观察到球囊扩张的立即或短期并发症。为了确定这项技术的使用和长期影响,有必要进行更大的队列研究和长期随访。
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引用次数: 1
Perilymph Fistula as a Complication of Eustachian Tube Dilation and Tympanoplasty 咽鼓管扩张和鼓室成形术的并发症——淋巴周围瘘
IF 0.6 Pub Date : 2022-05-07 DOI: 10.1155/2022/5978757
R. Kim, L. Scholtz, R. Jadeed, C. Pfeiffer, H. Sudhoff, I. Todt
Eustachian tube dilation (ETD) is an established, minimally invasive therapeutic approach for chronic eustachian tube dysfunction. The complications associated with performing a ETD are rare. A 22-year-old female patient presented with chronic otitis media on the right side and chronic obstructive tube dilation disorder on both sides. A type I tympanoplasty was performed on the right side because of a tympanic membrane perforation after a ETD on both sides without apparent complications. On the 5th postoperative day, she presented with headache, dizziness and hearing loss on the right side. There was a decrease of hearing threshold on the right side in the pure-tone audiogram and vHIT, cVEMP, and SVV were irregular. The β-2-transferrin test was positive. Since a right-sided perilymph fistula was suspected, an emergency tympanotomy was performed with a round window membrane cover with fascia on the right side. Intraoperatively, a regular, intact ossicular chain was found with a slightly moist middle ear mucosa. The round window membrane was covered by the promontorial lip. Under these measures, the patient's dizziness regressed. The right ear pure-tone threshold vHIT, cVEMP, and SVV normalized.
耳咽管扩张(ETD)是一种成熟的微创治疗慢性耳咽管功能障碍的方法。与ETD相关的并发症是罕见的。一位22岁的女性患者表现为右侧慢性中耳炎和两侧慢性阻塞性管道扩张障碍。由于双侧ETD后鼓膜穿孔,右侧行I型鼓室成形术,无明显并发症。术后第5天,患者出现头痛、头晕、右侧听力下降。纯音听力图右侧听阈降低,vHIT、cvpp、SVV不规则。β-2转铁蛋白试验呈阳性。由于怀疑右侧淋巴周围瘘管,我们在右侧进行了一个圆形膜覆盖的紧急鼓室切开术。术中发现规则完整的听骨链,中耳黏膜微湿。圆形的窗膜被突起的唇盖住。在这些措施下,病人的头晕消退了。右耳纯音阈值vHIT、cVEMP和SVV归一化。
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引用次数: 0
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Case Reports in Otolaryngology
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