Pub Date : 2018-08-16DOI: 10.1007/s11888-018-0412-y
M. Sonbol, T. Bekaii-Saab, A. Puccini, M. Salem
{"title":"Young Patients with Colorectal Cancer: Risk, Screening, and Treatment","authors":"M. Sonbol, T. Bekaii-Saab, A. Puccini, M. Salem","doi":"10.1007/s11888-018-0412-y","DOIUrl":"https://doi.org/10.1007/s11888-018-0412-y","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2018-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0412-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42862251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-23DOI: 10.1007/s11888-018-0408-7
Joseph R Iacona, Daniel E. Marks, Nicholas J Monteleone, C. Lutz
{"title":"Deciphering the Far-Reaching Functions of Non-coding RNA in Colorectal Cancer","authors":"Joseph R Iacona, Daniel E. Marks, Nicholas J Monteleone, C. Lutz","doi":"10.1007/s11888-018-0408-7","DOIUrl":"https://doi.org/10.1007/s11888-018-0408-7","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"115-127"},"PeriodicalIF":0.0,"publicationDate":"2018-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0408-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42370461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-12DOI: 10.1007/s11888-018-0405-x
A. Madkhali, Faisal A Alalem, Ghadeer R Aljuhani, Abdulsalam Alsharaabi, F. Alsaif, M. Hassanain
{"title":"Preoperative Selection and Optimization for Liver Resection in Colorectal Cancer Liver Metastases","authors":"A. Madkhali, Faisal A Alalem, Ghadeer R Aljuhani, Abdulsalam Alsharaabi, F. Alsaif, M. Hassanain","doi":"10.1007/s11888-018-0405-x","DOIUrl":"https://doi.org/10.1007/s11888-018-0405-x","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2018-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0405-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48427714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-28DOI: 10.1007/s11888-018-0407-8
E. Luterstein, A. Raldow, Yingli Yang, Percy Lee
{"title":"Functional Imaging Predictors of Response to Chemoradiation","authors":"E. Luterstein, A. Raldow, Yingli Yang, Percy Lee","doi":"10.1007/s11888-018-0407-8","DOIUrl":"https://doi.org/10.1007/s11888-018-0407-8","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"106-114"},"PeriodicalIF":0.0,"publicationDate":"2018-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0407-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46867713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-22DOI: 10.1007/s11888-018-0406-9
M. Allaix, A. Arezzo, M. Morino
{"title":"Current Trends on the Status of Transanal Endoscopic Microsurgery","authors":"M. Allaix, A. Arezzo, M. Morino","doi":"10.1007/s11888-018-0406-9","DOIUrl":"https://doi.org/10.1007/s11888-018-0406-9","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"98-105"},"PeriodicalIF":0.0,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0406-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48009708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-08DOI: 10.1007/s11888-018-0404-y
I. Park
{"title":"Outcomes of Rectal Cancer Patients With Low Sphincter-Preserving Operations Compared to Patients With Abdominoperineal Resection","authors":"I. Park","doi":"10.1007/s11888-018-0404-y","DOIUrl":"https://doi.org/10.1007/s11888-018-0404-y","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"81-88"},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0404-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49524847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-01Epub Date: 2018-03-01DOI: 10.1007/s11888-018-0403-z
Sarah F Andres, Kathy N Williams, Anil K Rustgi
Purpose of review: Metastatic colorectal cancer (CRC) is a vexing clinical problem. In contrast to early stage disease, once CRC metastasizes to other organs, long-term survival is compromised. We seek to review the molecular pathogenesis, animal models, and functional genomics for an enhanced understanding of how CRC metastasizes and how this can be exploited therapeutically.
Recent findings: Mouse models may recapitulate certain aspects of metastatic human CRC and allow for studies to identify regulators of metastasis. Modulation of transcription factors, onco-proteins, or tumor suppressors have been identified to activate known metastatic pathways. CD44 variants, microRNAs and RNA binding proteins are emerging as metastatic modulators.
Summary: CRC metastasis is a multi-faceted and heterogeneous disease. Despite common pathways contributing to metastatic development, there are numerous variables that modulate metastatic signals in subsets of patients. It is paramount that studies continue to investigate metastatic drivers, enhancers and inhibitors in CRC to develop therapeutic targets and improve disease outcomes.
{"title":"The Molecular Basis of Metastatic Colorectal Cancer.","authors":"Sarah F Andres, Kathy N Williams, Anil K Rustgi","doi":"10.1007/s11888-018-0403-z","DOIUrl":"10.1007/s11888-018-0403-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Metastatic colorectal cancer (CRC) is a vexing clinical problem. In contrast to early stage disease, once CRC metastasizes to other organs, long-term survival is compromised. We seek to review the molecular pathogenesis, animal models, and functional genomics for an enhanced understanding of how CRC metastasizes and how this can be exploited therapeutically.</p><p><strong>Recent findings: </strong>Mouse models may recapitulate certain aspects of metastatic human CRC and allow for studies to identify regulators of metastasis. Modulation of transcription factors, onco-proteins, or tumor suppressors have been identified to activate known metastatic pathways. CD44 variants, microRNAs and RNA binding proteins are emerging as metastatic modulators.</p><p><strong>Summary: </strong>CRC metastasis is a multi-faceted and heterogeneous disease. Despite common pathways contributing to metastatic development, there are numerous variables that modulate metastatic signals in subsets of patients. It is paramount that studies continue to investigate metastatic drivers, enhancers and inhibitors in CRC to develop therapeutic targets and improve disease outcomes.</p>","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 2","pages":"69-79"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141197/pdf/nihms947362.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36511266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-02DOI: 10.1007/s11888-018-0401-1
L. Taveras, H. Cunningham, J. Imran
{"title":"Can We Reliably Predict a Clinical Complete Response in Rectal Cancer? Current Trends and Future Strategies","authors":"L. Taveras, H. Cunningham, J. Imran","doi":"10.1007/s11888-018-0401-1","DOIUrl":"https://doi.org/10.1007/s11888-018-0401-1","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"56-63"},"PeriodicalIF":0.0,"publicationDate":"2018-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0401-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42483864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-26DOI: 10.1007/s11888-018-0402-0
P. Bangeas, A. Chorti, T. Papavramidis, G. Tsoulfas
{"title":"Current Trends on the Treatment Sequence for Colorectal Cancer with Liver Metastases","authors":"P. Bangeas, A. Chorti, T. Papavramidis, G. Tsoulfas","doi":"10.1007/s11888-018-0402-0","DOIUrl":"https://doi.org/10.1007/s11888-018-0402-0","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0402-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46551406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-08DOI: 10.1007/s11888-018-0397-6
F. Swaid, A. Tsung
{"title":"Current Management of Liver Metastasis From Colorectal Cancer","authors":"F. Swaid, A. Tsung","doi":"10.1007/s11888-018-0397-6","DOIUrl":"https://doi.org/10.1007/s11888-018-0397-6","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":"14 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"2018-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0397-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47727281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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