Hans Kemperman, Ruben E A Musson, Wouter Tiel Groenestege, Carlyn V Kouwenberg
{"title":"Unexpected High Vitamin D Results.","authors":"Hans Kemperman, Ruben E A Musson, Wouter Tiel Groenestege, Carlyn V Kouwenberg","doi":"10.1093/jalm/jfaf146","DOIUrl":"https://doi.org/10.1093/jalm/jfaf146","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":"10 6","pages":"1768-1770"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on Abnormal Thyroid Function Test in a Patient Taking Carbamazepine.","authors":"Christopher W Farnsworth","doi":"10.1093/jalm/jfaf105","DOIUrl":"10.1093/jalm/jfaf105","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1727-1728"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bobby Li, Catherine Rollo, Richard King, Simon Thompson, Chris Florkowski
{"title":"Reference Intervals for Ceruloplasmin Should Account for Age, Sex, Method, and Local Population.","authors":"Bobby Li, Catherine Rollo, Richard King, Simon Thompson, Chris Florkowski","doi":"10.1093/jalm/jfaf121","DOIUrl":"10.1093/jalm/jfaf121","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1762-1763"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miyo K Chatanaka, Maria Pascual Lorén, Eleftherios P Diamandis
{"title":"Total Prostate-Specific Antigen Testing in Capillary Samples: Back to the Future.","authors":"Miyo K Chatanaka, Maria Pascual Lorén, Eleftherios P Diamandis","doi":"10.1093/jalm/jfaf113","DOIUrl":"10.1093/jalm/jfaf113","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1758-1759"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Reference Values of Ceruloplasmin across the Adult Age Range in a Large Italian Healthy Population.","authors":"","doi":"10.1093/jalm/jfaf122","DOIUrl":"10.1093/jalm/jfaf122","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1773"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sercan Erol, Evin Kocatürk, Özben Ö Işıklar, Hava Ü Teke
{"title":"From Suspicion of IVIG Interference to Diagnosis of Rare Syndrome.","authors":"Sercan Erol, Evin Kocatürk, Özben Ö Işıklar, Hava Ü Teke","doi":"10.1093/jalm/jfaf134","DOIUrl":"10.1093/jalm/jfaf134","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1715-1720"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Associations between Growth Differentiation Factor 15, Cardiac Troponin T, and N-terminal pro-B-type Natriuretic Peptide, and Future Myocardial Fibrosis Assessed by Cardiac Magnetic Resonance Imaging: Data from the Akershus Cardiac Examination 1950 Study.","authors":"","doi":"10.1093/jalm/jfaf086","DOIUrl":"10.1093/jalm/jfaf086","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1775"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Reply to Total Prostate-Specific Antigen Testing in Capillary Samples: Back to the Future.","authors":"Ravinder Sodi","doi":"10.1093/jalm/jfaf114","DOIUrl":"10.1093/jalm/jfaf114","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1760-1761"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on From Suspicion of Intravenous Immunoglobin Interference to Diagnosis of Rare Syndrome.","authors":"Mary Kathryn Bohn","doi":"10.1093/jalm/jfaf142","DOIUrl":"10.1093/jalm/jfaf142","url":null,"abstract":"","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1721-1722"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gema García de la Rosa, Silvia de Las Heras Flórez, Mercedes Carretero Pérez, Jorge Nuevo García
Background: Mass spectrometry (MS) is emerging as a transformative diagnostic tool for plasma cell disorders, including multiple myeloma, Waldenström macroglobulinemia, and light chain amyloidosis. Traditional diagnostic methods such as serum protein electrophoresis, immunofixation electrophoresis, and serum free light chain assays, though effective, have limitations in sensitivity and specificity. These techniques may miss small monoclonal proteins or be affected by therapeutic antibody interference.
Content: Recent advances focus on top-down MS techniques, particularly matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and monoclonal immunoglobulin rapid accurate mass measurement (miRAMM). These methods analyze intact monoclonal proteins to enhance detection sensitivity and specificity. MALDI-TOF offers a streamlined workflow suitable for clinical laboratories, while miRAMM provides highly precise mass measurements, albeit requiring more sophisticated instrumentation.MS has demonstrated superior capabilities in detecting monoclonal proteins, including the ability to distinguish them from therapeutic antibodies. Additionally, MS enables structural characterization of monoclonal proteins, such as glycosylation patterns linked to amyloidosis. Notably, emerging evidence indicates that MS may match or surpass the sensitivity of molecular techniques. These include next-generation sequencing and next-generation flow cytometry, which are commonly applied to bone marrow biopsy for minimal residual disease detection, providing a less invasive alternative for disease monitoring.
Summary: MS, particularly MALDI-TOF and miRAMM, represents a promising advancement in the diagnosis and monitoring of plasma cell disorders. Its high sensitivity, efficiency, and noninvasive nature support its potential to complement or replace existing diagnostic methods, improving patient care and clinical outcomes as the technology continues to evolve.
{"title":"The Transformative Role of Mass Spectrometry in Diagnosing and Monitoring Monoclonal Gammopathies and Plasma Cell Disorders.","authors":"Gema García de la Rosa, Silvia de Las Heras Flórez, Mercedes Carretero Pérez, Jorge Nuevo García","doi":"10.1093/jalm/jfaf133","DOIUrl":"10.1093/jalm/jfaf133","url":null,"abstract":"<p><strong>Background: </strong>Mass spectrometry (MS) is emerging as a transformative diagnostic tool for plasma cell disorders, including multiple myeloma, Waldenström macroglobulinemia, and light chain amyloidosis. Traditional diagnostic methods such as serum protein electrophoresis, immunofixation electrophoresis, and serum free light chain assays, though effective, have limitations in sensitivity and specificity. These techniques may miss small monoclonal proteins or be affected by therapeutic antibody interference.</p><p><strong>Content: </strong>Recent advances focus on top-down MS techniques, particularly matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and monoclonal immunoglobulin rapid accurate mass measurement (miRAMM). These methods analyze intact monoclonal proteins to enhance detection sensitivity and specificity. MALDI-TOF offers a streamlined workflow suitable for clinical laboratories, while miRAMM provides highly precise mass measurements, albeit requiring more sophisticated instrumentation.MS has demonstrated superior capabilities in detecting monoclonal proteins, including the ability to distinguish them from therapeutic antibodies. Additionally, MS enables structural characterization of monoclonal proteins, such as glycosylation patterns linked to amyloidosis. Notably, emerging evidence indicates that MS may match or surpass the sensitivity of molecular techniques. These include next-generation sequencing and next-generation flow cytometry, which are commonly applied to bone marrow biopsy for minimal residual disease detection, providing a less invasive alternative for disease monitoring.</p><p><strong>Summary: </strong>MS, particularly MALDI-TOF and miRAMM, represents a promising advancement in the diagnosis and monitoring of plasma cell disorders. Its high sensitivity, efficiency, and noninvasive nature support its potential to complement or replace existing diagnostic methods, improving patient care and clinical outcomes as the technology continues to evolve.</p>","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":"1658-1663"},"PeriodicalIF":1.9,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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