首页 > 最新文献

Craniomaxillofacial Trauma & Reconstruction最新文献

英文 中文
Current Evidence for the Management of Edentulous Atrophic Mandible Fractures: A PRISMA-SWiM Guided Review. 无牙萎缩性下颌骨骨折治疗的最新证据:prism - swim引导综述。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-12-01 DOI: 10.1177/19433875221115585
Rathindra N Bera, Preeti Tiwari

Study design: PRISMA-SWiM guided systematic review.

Objective: 1. Provide consistent evidence regarding the management of atrophic mandible fractures; 2. To search, evaluate and validate existing guidelines if any for the management; 3. Provide evidence regarding specific management of condylar fractures in the atrophic mandible; 4. To address the clinical applicability of bone grafts.

Methods: A systematic review was conducted using the PRISMA-SWiM protocol. PROSPERO ID: CRD42021235111. Studies with adequate data on outcome, treatment methods were selected. Isolated case reports, case series, and non-human studies were excluded. Quality assessment was done using Newcastle -Ottawa scale. The level of evidence was assessed using Oxford Level of Evidence.

Results: Mandibular body was the most common type of fracture. Self falls and RTA were the most common etiologies. Condylar fracture was most commonly managed conservatively with ORIF employed in few studies. For the mandible compression and non-compression osteosynthesis were used. Bone grafts were used in cases with segmental defects or cases requiring augmentation.

Conclusions: There is lack of proper evidence to definitely conclude any single treatment modality. However, the consensus is towards ORIF. Reconstruction plates are preferred by many authors. However, unilateral fractures may be managed by miniplates. Bilateral fractures require more rigid fixations. Open reduction and internal fixation of condylar fracture is indicated in cases with displacement or low-level fractures.

研究设计:prism - swim引导的系统评价。目的:1。为萎缩性下颌骨骨折的治疗提供一致的证据;2. 搜寻、评估及验证现有的管理指引(如有);3. 为萎缩性下颌骨髁突骨折的具体治疗提供证据;4. 探讨骨移植的临床适用性。方法:采用PRISMA-SWiM方案进行系统评价。普洛斯彼罗id: crd42021235111。选择具有足够结果和治疗方法数据的研究。排除了孤立病例报告、病例系列和非人类研究。质量评估采用纽卡斯尔-渥太华量表。证据水平采用牛津证据水平评估。结果:下颌体骨折是最常见的骨折类型。自我跌倒和RTA是最常见的病因。在少数研究中,髁突骨折通常采用ORIF保守治疗。下颌骨采用压迫式和非压迫式骨固定。骨移植用于有节段缺损或需要增强的病例。结论:缺乏适当的证据来确定任何单一的治疗方式。然而,共识是倾向于ORIF。许多作者首选重建钢板。然而,单侧骨折可以用微型钢板治疗。双侧骨折需要更坚固的固定。髁突骨折的切开复位内固定适用于移位或低位骨折。
{"title":"Current Evidence for the Management of Edentulous Atrophic Mandible Fractures: A PRISMA-SWiM Guided Review.","authors":"Rathindra N Bera, Preeti Tiwari","doi":"10.1177/19433875221115585","DOIUrl":"10.1177/19433875221115585","url":null,"abstract":"<p><strong>Study design: </strong>PRISMA-SWiM guided systematic review.</p><p><strong>Objective: </strong>1. Provide consistent evidence regarding the management of atrophic mandible fractures; 2. To search, evaluate and validate existing guidelines if any for the management; 3. Provide evidence regarding specific management of condylar fractures in the atrophic mandible; 4. To address the clinical applicability of bone grafts.</p><p><strong>Methods: </strong>A systematic review was conducted using the PRISMA-SWiM protocol. PROSPERO ID: CRD42021235111. Studies with adequate data on outcome, treatment methods were selected. Isolated case reports, case series, and non-human studies were excluded. Quality assessment was done using Newcastle -Ottawa scale. The level of evidence was assessed using Oxford Level of Evidence.</p><p><strong>Results: </strong>Mandibular body was the most common type of fracture. Self falls and RTA were the most common etiologies. Condylar fracture was most commonly managed conservatively with ORIF employed in few studies. For the mandible compression and non-compression osteosynthesis were used. Bone grafts were used in cases with segmental defects or cases requiring augmentation.</p><p><strong>Conclusions: </strong>There is lack of proper evidence to definitely conclude any single treatment modality. However, the consensus is towards ORIF. Reconstruction plates are preferred by many authors. However, unilateral fractures may be managed by miniplates. Bilateral fractures require more rigid fixations. Open reduction and internal fixation of condylar fracture is indicated in cases with displacement or low-level fractures.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77205215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of NGF and Photobiomodulation Therapy on Crush Nerve Injury and Fracture Healing: A Stereological and Histopathological Study in an Animal Model. 神经生长因子和光生物调节治疗对挤压神经损伤和骨折愈合的影响:动物模型的体视学和组织病理学研究。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-11-15 DOI: 10.1177/19433875221138175
Esengül Şen, Nilüfer Özkan, Mehmet Emin Önger, Süleyman Kaplan

Study design: A stereological and histopathological study in an animal model.

Objective: This study explores the effects of the nerve growth factor and photobiomodulation therapy on the damaged nerve tissue and fracture healing.

Methods: A total of 24 rabbits were divided into 4 groups: control group (n = 5), nerve growth factor (NGF) group (n = 7), photobiomodulation (PBMT) group (n = 6), and nerve growth factor and photobiomodulation therapy (NGF+PBMT) group (n = 6). The vertical fracture was performed between the mental foramen and the first premolar, and the mental nerve was crushed for 30 seconds with a standard serrated clamp with a force of approximately 50 N in all groups. The control group received an isotonic solution (.02 mL, .09% NaCl) to the operation site locally. The NGF group received 1 μg human NGF-β/.9% .2 mL NaCl solution for 7 days locally. The PBMT group received PBMT treatment (GaAlAs laser, 810 nm, .3 W, 18 J/cm2) every 48 hours for 14 sessions following the surgery. The NGF+PBMT group received both NGF and PBMT treatment as described above. After 28 days, the bone tissues and mental nerves from all groups were harvested and histologically and stereologically analyzed.

Results: According to the stereological results, the volume of the new vessel and the volume of the new bone were significantly higher in the PBMT group than in other groups (P < .001). According to the histopathological examinations, higher myelinated axons were observed in experimental groups than in the control group.

Conclusions: As a result, PBMT has beneficial effects on bone regeneration. Based on the light microscopic evaluation, more regenerated axon populations were observed in the NGF group than in the PBMT and PBMT + NGF groups in terms of myelinated axon content.

研究设计:在动物模型中进行立体学和组织病理学研究。目的:探讨神经生长因子和光生物调节治疗对损伤神经组织及骨折愈合的影响。方法:共有24只兔子被分为4组:对照组(n = 5),神经生长因子(神经生长因子)组(n = 7), photobiomodulation (PBMT)组(n = 6)和神经生长因子和photobiomodulation疗法(神经生长因子+ PBMT)组(n = 6)。之间的垂直裂缝进行精神孔和第一前磨牙和精神神经被30秒用一个标准的锯齿状的夹力的大约50 n组。对照组给予等渗溶液(。2 mL, 0.09% NaCl)局部滴入手术部位。NGF组给予人NGF-β/ 1 μg;9% .2 mL NaCl溶液局部浸泡7天。PBMT组术后每48小时接受PBMT治疗(GaAlAs激光,810 nm, 0.3 W, 18 J/cm2),共14次。NGF+PBMT组同时接受上述NGF和PBMT治疗。28 d后,取各组骨组织和精神神经进行组织学和立体学分析。结果:体视学结果显示,PBMT组新生血管体积和新生骨体积明显高于其他组(P < 0.001)。组织病理学检查显示,实验组的髓鞘轴突明显高于对照组。结论:PBMT对骨再生有一定的促进作用。通过光镜观察,在髓鞘轴突含量方面,NGF组比PBMT和PBMT + NGF组观察到更多的再生轴突种群。
{"title":"Effects of NGF and Photobiomodulation Therapy on Crush Nerve Injury and Fracture Healing: A Stereological and Histopathological Study in an Animal Model.","authors":"Esengül Şen, Nilüfer Özkan, Mehmet Emin Önger, Süleyman Kaplan","doi":"10.1177/19433875221138175","DOIUrl":"10.1177/19433875221138175","url":null,"abstract":"<p><strong>Study design: </strong>A stereological and histopathological study in an animal model.</p><p><strong>Objective: </strong>This study explores the effects of the nerve growth factor and photobiomodulation therapy on the damaged nerve tissue and fracture healing.</p><p><strong>Methods: </strong>A total of 24 rabbits were divided into 4 groups: control group (n = 5), nerve growth factor (NGF) group (n = 7), photobiomodulation (PBMT) group (n = 6), and nerve growth factor and photobiomodulation therapy (NGF+PBMT) group (n = 6). The vertical fracture was performed between the mental foramen and the first premolar, and the mental nerve was crushed for 30 seconds with a standard serrated clamp with a force of approximately 50 N in all groups. The control group received an isotonic solution (.02 mL, .09% NaCl) to the operation site locally. The NGF group received 1 μg human NGF-β/.9% .2 mL NaCl solution for 7 days locally. The PBMT group received PBMT treatment (GaAlAs laser, 810 nm, .3 W, 18 J/cm<sup>2</sup>) every 48 hours for 14 sessions following the surgery. The NGF+PBMT group received both NGF and PBMT treatment as described above. After 28 days, the bone tissues and mental nerves from all groups were harvested and histologically and stereologically analyzed.</p><p><strong>Results: </strong>According to the stereological results, the volume of the new vessel and the volume of the new bone were significantly higher in the PBMT group than in other groups (P < .001). According to the histopathological examinations, higher myelinated axons were observed in experimental groups than in the control group.</p><p><strong>Conclusions: </strong>As a result, PBMT has beneficial effects on bone regeneration. Based on the light microscopic evaluation, more regenerated axon populations were observed in the NGF group than in the PBMT and PBMT + NGF groups in terms of myelinated axon content.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82690653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motorcycle Accidents are the Strongest Risk Factor for Panfacial Fractures Among Pediatric Patients. 摩托车事故是儿童全面骨折的最大危险因素。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-08-03 DOI: 10.1177/19433875221116961
Dani Stanbouly, Dylan Koh, Jordan Halsey, Firat Selvi, Fereshteh Goudarzi, Kevin Arce, Sung-Kiang Chuang

Study design: A retrospective cohort study was conducted using the Kids' Inpatient Database from 2000 to 2014. Subjects were included if they were 18 years and younger and suffered any type of facial fracture.

Objective: The purpose this study was to determine the risk factors for incurring panfacial fractures among the pediatric population.

Methods: The primary predictor variables were a set of heterogenous variables that included patient characteristics, injury characteristics, hospitalization outcomes. The primary outcome variable was panfacial fracture. Logistic regression was used to determine the independent risk factors for panfacial fractures.

Results: Relative to infants and toddlers, teenagers were nearly three times more likely to sustain panfacial fractures (P < .01). Relative to no chronic conditions, patients with one or more chronic conditions were more likely to incur panfacial fractures. Motorcycle accidents were over three times more likely (P < .01) to result in panfacial fractures while car accidents were over two times more likely (P < .01) to result in panfacial fractures. Falls were less likely (OR, .39; P < .01) to result in panfacial fractures.

Conclusions: Motor vehicle accidents was a major risk factor for panfacial fractures. Teenagers are also found to have an increased risk for panfacial fractures relative to infants and toddlers. Each additional chronic condition was a significant risk factor for suffering panfacial fractures relative to not having any chronic condition at all. In contrast, falls independently decreased the risk of incurring a panfacial fractures. Special attention should be given to safety precautions when occupying a motor vehicle.

研究设计:采用2000 - 2014年儿童住院患者数据库进行回顾性队列研究。受试者年龄在18岁及以下,且患有任何类型的面部骨折。目的:本研究的目的是确定在儿童人群中发生全面骨折的危险因素。方法:主要预测变量是一组异质性变量,包括患者特征、损伤特征、住院结果。主要结局变量为全面骨折。采用Logistic回归确定全面骨折的独立危险因素。结果:青少年发生全面骨折的可能性是婴幼儿的近3倍(P < 0.01)。与无慢性疾病的患者相比,有一种或多种慢性疾病的患者更容易发生全面骨折。摩托车事故导致全面骨折的可能性是机动车事故的3倍以上(P < 0.01),机动车事故导致全面骨折的可能性是机动车事故的2倍以上(P < 0.01)。摔倒的可能性较小(OR, 0.39;P < 0.01)导致全面骨折。结论:机动车事故是全面骨折的主要危险因素。与婴幼儿相比,青少年患全面骨折的风险也更高。与没有任何慢性疾病相比,每一种额外的慢性疾病都是患全面骨折的重要危险因素。相反,单独跌倒可降低发生全面骨折的风险。乘坐机动车辆时,应特别注意安全预防措施。
{"title":"Motorcycle Accidents are the Strongest Risk Factor for Panfacial Fractures Among Pediatric Patients.","authors":"Dani Stanbouly, Dylan Koh, Jordan Halsey, Firat Selvi, Fereshteh Goudarzi, Kevin Arce, Sung-Kiang Chuang","doi":"10.1177/19433875221116961","DOIUrl":"10.1177/19433875221116961","url":null,"abstract":"<p><strong>Study design: </strong>A retrospective cohort study was conducted using the Kids' Inpatient Database from 2000 to 2014. Subjects were included if they were 18 years and younger and suffered any type of facial fracture.</p><p><strong>Objective: </strong>The purpose this study was to determine the risk factors for incurring panfacial fractures among the pediatric population.</p><p><strong>Methods: </strong>The primary predictor variables were a set of heterogenous variables that included patient characteristics, injury characteristics, hospitalization outcomes. The primary outcome variable was panfacial fracture. Logistic regression was used to determine the independent risk factors for panfacial fractures.</p><p><strong>Results: </strong>Relative to infants and toddlers, teenagers were nearly three times more likely to sustain panfacial fractures (<i>P</i> < .01). Relative to no chronic conditions, patients with one or more chronic conditions were more likely to incur panfacial fractures. Motorcycle accidents were over three times more likely (<i>P</i> < .01) to result in panfacial fractures while car accidents were over two times more likely (<i>P</i> < .01) to result in panfacial fractures. Falls were less likely (OR, .39; <i>P</i> < .01) to result in panfacial fractures.</p><p><strong>Conclusions: </strong>Motor vehicle accidents was a major risk factor for panfacial fractures. Teenagers are also found to have an increased risk for panfacial fractures relative to infants and toddlers. Each additional chronic condition was a significant risk factor for suffering panfacial fractures relative to not having any chronic condition at all. In contrast, falls independently decreased the risk of incurring a panfacial fractures. Special attention should be given to safety precautions when occupying a motor vehicle.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82697541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Study of Orbital and Orbitozygomaticomaxillary Complex Fractures Treated at Aalesund Hospital Between 2002 and 2017. 2002年至2017年在阿勒松医院治疗的眶、眶颧、腋窝复合骨折回顾性研究。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-11-10 DOI: 10.1177/19433875221135932
Ingvild Årøen Lein, Tore Bjørnland, Lado Lako Loro

Study design: Retrospective study.

Objective: To evaluate patient demographics, surgical management, and complications of orbital and orbitozygomaticomaxillary complex (OZMC) fractures treated at a district hospital in Norway.

Methods: The medical records of patients with orbital fractures treated at Aalesund hospital between January 2002 and July 2017 were reviewed. Data on demographics, signs and symptoms, cause of injury, fracture type, associated fractures, surgical management, and complications were collected.

Results: A total of 36 patients were reviewed. Males predominated (1:4.1), and fractures occurred mostly in patients 40-59 years (mean 41.8 years). Interpersonal violence was the leading cause of injury, followed by falls. Alcohol was significantly associated with assault caused fractures (P = .001). Orbitozygomaticomaxillary fractures were the most frequent, followed by pure orbital fractures. Clinical findings included periorbital ecchymosis (72%), swelling (56%), sensory nerve dysfunction (53%), diplopia (22%), and restricted eye motility (22%). Commotio cerebri was observed in more than half of our sample and 47% had other facial bone fractures. Referral to tertiary hospitals was done in 19% of the cases. The main treatment done was open reduction and internal fixation (ORIF) (45%). Infection was diagnosed in 17% and managed with antibiotics.

Conclusions: The incidence of orbital and OZMC fractures in Moere and Romsdal county in western Norway was low, occurring mainly in males over 40 years. The mechanism of injury was predominantly interpersonal violence and falls. A high proportion of the sample had minor traumatic brain injury (mTBI).

研究设计:回顾性研究。目的:评价挪威一家地区医院治疗的眼眶和眶颧腋窝复合体(OZMC)骨折的患者人口统计学、手术处理和并发症。方法:回顾性分析2002年1月至2017年7月在阿勒松医院治疗的眶部骨折患者的病历。收集了人口统计学、体征和症状、损伤原因、骨折类型、相关骨折、手术处理和并发症的数据。结果:共回顾36例患者。男性居多(1:4.1),骨折多发生在40-59岁(平均41.8岁)。人际暴力是造成伤害的主要原因,其次是跌倒。酒精与攻击引起的骨折显著相关(P = 0.001)。眶颧腋骨折最常见,其次为单纯眶骨折。临床表现包括眼眶周围淤斑(72%)、肿胀(56%)、感觉神经功能障碍(53%)、复视(22%)和眼球运动受限(22%)。在我们的样本中,超过一半的人观察到大脑活动,47%的人有其他面部骨折。19%的病例转诊到三级医院。主要治疗方法为切开复位内固定(ORIF)(45%)。17%的人被诊断为感染,并使用抗生素进行治疗。结论:挪威西部Moere和Romsdal县眶部和OZMC骨折发生率较低,主要发生在40岁以上的男性。伤害机制主要是人际暴力和跌倒。高比例的样本有轻度创伤性脑损伤(mTBI)。
{"title":"Retrospective Study of Orbital and Orbitozygomaticomaxillary Complex Fractures Treated at Aalesund Hospital Between 2002 and 2017.","authors":"Ingvild Årøen Lein, Tore Bjørnland, Lado Lako Loro","doi":"10.1177/19433875221135932","DOIUrl":"10.1177/19433875221135932","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective study.</p><p><strong>Objective: </strong>To evaluate patient demographics, surgical management, and complications of orbital and orbitozygomaticomaxillary complex (OZMC) fractures treated at a district hospital in Norway.</p><p><strong>Methods: </strong>The medical records of patients with orbital fractures treated at Aalesund hospital between January 2002 and July 2017 were reviewed. Data on demographics, signs and symptoms, cause of injury, fracture type, associated fractures, surgical management, and complications were collected.</p><p><strong>Results: </strong>A total of 36 patients were reviewed. Males predominated (1:4.1), and fractures occurred mostly in patients 40-59 years (mean 41.8 years). Interpersonal violence was the leading cause of injury, followed by falls. Alcohol was significantly associated with assault caused fractures (<i>P =</i> .001). Orbitozygomaticomaxillary fractures were the most frequent, followed by pure orbital fractures. Clinical findings included periorbital ecchymosis (72%), swelling (56%), sensory nerve dysfunction (53%), diplopia (22%), and restricted eye motility (22%). Commotio cerebri was observed in more than half of our sample and 47% had other facial bone fractures. Referral to tertiary hospitals was done in 19% of the cases. The main treatment done was open reduction and internal fixation (ORIF) (45%). Infection was diagnosed in 17% and managed with antibiotics.</p><p><strong>Conclusions: </strong>The incidence of orbital and OZMC fractures in Moere and Romsdal county in western Norway was low, occurring mainly in males over 40 years. The mechanism of injury was predominantly interpersonal violence and falls. A high proportion of the sample had minor traumatic brain injury (mTBI).</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77972820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resilience at the End of the Year: From Crisis to Innovation and the Future of Craniomaxillofacial Trauma and Reconstruction. 年底的恢复力:从危机到创新和颅颌面创伤与重建的未来。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2023-11-16 DOI: 10.1177/19433875231217130
{"title":"Resilience at the End of the Year: From Crisis to Innovation and the Future of Craniomaxillofacial Trauma and Reconstruction.","authors":"","doi":"10.1177/19433875231217130","DOIUrl":"https://doi.org/10.1177/19433875231217130","url":null,"abstract":"","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulating A Subcondylar Mandibular Fracture With Intraoral Open Reduction and Internal Fixation: A Novel Education Tool for Residents. 用口内切开复位和内固定模拟下颌髁下骨折:一种新的居民教育工具。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-09-21 DOI: 10.1177/19433875221129673
Francisco Rojas, Sebastian Tapia, Andrés Campolo, Alex Vargas, Hernán Ramírez, Benito K Benitez, Cristian Teuber

Study design: Face and content validation of a surgical simulation model.

Objective: Open reduction and internal fixation in displaced subcondylar mandibular fractures is standard care. This requires an extraoral (eg: retromandibular, transparotideal) or intraoral approach. An intraoral approach requires further training since specialized instrumentation such as the 90° screwdriver system and endoscopes might be needed. Currently, no simulation models are available for training residents in intraoral reduction and fixation of subcondylar mandibular fractures. Therefore, we present a validated simulation model for intraoral treatment of subcondylar mandibular fractures.

Methods: Based on a computer tomography data set, we designed and printed a 3D model of a mandible with a unilateral subcondylar fracture. To simulate intraoral work depth, it was positioned inside a dental phantom. We tested the model by a group of experts (n = 8), simulating intraoral reduction and fixation of a unilateral subcondylar fracture, using a 90° screwdriver system, a 1.0 subcondylar plate (lambda), and 5-6 mm screws.We assessed Face and Content validity by survey.

Results: We provided an open-source printable fracture model. Printing costs were approximately US $10. Experts "Agreed" the model resembling the real scenario and its use for training intraoral reduction and fixation of subcondylar mandibular fractures.

Conclusions: We developed a low cost, reproducible, open-source simulator for subcondylar mandibular fractures. Face and Content validity was achieved through evaluation by a group of experts.

研究设计:手术模拟模型的面部和内容验证。目的:切开复位内固定治疗移位的下颌髁下骨折是标准的治疗方法。这需要口外入路(如:下颌骨后、经鼻窦)或口内入路。口腔内入路需要进一步的培训,因为可能需要专门的器械,如90°螺丝刀系统和内窥镜。目前,没有模拟模型可用于培训住院医师进行下颌髁下骨折的口内复位和固定。因此,我们提出了一个有效的模拟模型,用于下颌髁下骨折的口腔内治疗。方法:基于计算机断层数据集,设计并打印单侧髁下骨折的下颌骨三维模型。为了模拟口腔内工作深度,将其放置在牙模内。我们由一组专家(n = 8)对模型进行了测试,使用90°螺丝刀系统、1.0髁下钢板(lambda)和5-6 mm螺钉模拟单侧髁下骨折的口内复位和固定。我们通过问卷调查来评估Face和Content效度。结果:我们提供了一个开源的可打印骨折模型。印刷费用约为10美元。专家“同意”该模型与真实场景相似,并将其用于训练下颌髁下骨折的口内复位和固定。结论:我们开发了一个低成本、可重复、开源的下颌髁下骨折模拟器。面孔效度和内容效度由专家小组评定。
{"title":"Simulating A Subcondylar Mandibular Fracture With Intraoral Open Reduction and Internal Fixation: A Novel Education Tool for Residents.","authors":"Francisco Rojas, Sebastian Tapia, Andrés Campolo, Alex Vargas, Hernán Ramírez, Benito K Benitez, Cristian Teuber","doi":"10.1177/19433875221129673","DOIUrl":"10.1177/19433875221129673","url":null,"abstract":"<p><strong>Study design: </strong>Face and content validation of a surgical simulation model.</p><p><strong>Objective: </strong>Open reduction and internal fixation in displaced subcondylar mandibular fractures is standard care. This requires an extraoral (eg: retromandibular, transparotideal) or intraoral approach. An intraoral approach requires further training since specialized instrumentation such as the 90° screwdriver system and endoscopes might be needed. Currently, no simulation models are available for training residents in intraoral reduction and fixation of subcondylar mandibular fractures. Therefore, we present a validated simulation model for intraoral treatment of subcondylar mandibular fractures.</p><p><strong>Methods: </strong>Based on a computer tomography data set, we designed and printed a 3D model of a mandible with a unilateral subcondylar fracture. To simulate intraoral work depth, it was positioned inside a dental phantom. We tested the model by a group of experts (n = 8), simulating intraoral reduction and fixation of a unilateral subcondylar fracture, using a 90° screwdriver system, a 1.0 subcondylar plate (lambda), and 5-6 mm screws.We assessed Face and Content validity by survey.</p><p><strong>Results: </strong>We provided an open-source printable fracture model. Printing costs were approximately US $10. Experts \"Agreed\" the model resembling the real scenario and its use for training intraoral reduction and fixation of subcondylar mandibular fractures.</p><p><strong>Conclusions: </strong>We developed a low cost, reproducible, open-source simulator for subcondylar mandibular fractures. Face and Content validity was achieved through evaluation by a group of experts.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89498756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Surgical Decompression and Steroid Therapy for the Management of Traumatic Optic Neuropathy: A Systematic Review and Meta-Analysis. 手术减压和类固醇治疗外伤性视神经病变的比较:系统回顾和荟萃分析。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-11-28 DOI: 10.1177/19433875221142682
Sameer Pandey, Gosla S Reddy, Ashi Chug, Ashutosh Dixit, Balgovind S Raja

Study design: A systematic review and meta-analysis.

Objective: Treatment of traumatic optic neuropathy (TON) has been a subject of debate for many decades due to the scarcity of evidence-based treatment protocols. This review compares surgical decompression (SD) and steroid therapy (ST) as treatment approaches in TON patients.

Methods: A PRISMA-guided systematic review using PubMed, Embase, Ovid and Scopus databases was performed till the last search date of July 31st 2021. The outcome of interest was an improvement in visual acuity. A meta-analysis of the odds ratio was performed using a random-effect model and sub-group analysis based upon criteria for assessment of improvement in visual acuity.

Results: Sixteen studies (including 1046 patients) were included in the review. The review could identify 590 patients treated with SD and 456 treated with ST. In addition, there was a second cohort of patients presenting with NLP (no light perception). A meta-analysis with a sub-group analysis revealed that there was statistically no significant difference between the two treatment approaches in terms of improvement in VA.

Conclusions: There is no difference in treatment results of SD or ST for TON. Several treatment protocols and different criteria for assessing visual acuity led to difficulty in generating evidence for selecting the correct treatment approach.

研究设计:系统回顾和荟萃分析。目的:由于缺乏基于证据的治疗方案,创伤性视神经病变(TON)的治疗已经争论了几十年。本综述比较了手术减压(SD)和类固醇治疗(ST)作为治疗TON患者的方法。方法:使用PubMed、Embase、Ovid和Scopus数据库进行prisma引导的系统评价,最后检索日期为2021年7月31日。结果是视力的改善。采用随机效应模型和基于视力改善评估标准的亚组分析对优势比进行meta分析。结果:16项研究(包括1046例患者)纳入本综述。该综述确定了590名接受SD治疗的患者和456名接受st治疗的患者。此外,还有第二组患者出现NLP(无光感知)。一项亚组分析的荟萃分析显示,两种治疗方法在va改善方面无统计学差异。结论:SD和ST治疗TON的治疗结果无差异。几种治疗方案和评估视力的不同标准导致难以产生选择正确治疗方法的证据。
{"title":"Comparison of Surgical Decompression and Steroid Therapy for the Management of Traumatic Optic Neuropathy: A Systematic Review and Meta-Analysis.","authors":"Sameer Pandey, Gosla S Reddy, Ashi Chug, Ashutosh Dixit, Balgovind S Raja","doi":"10.1177/19433875221142682","DOIUrl":"10.1177/19433875221142682","url":null,"abstract":"<p><strong>Study design: </strong>A systematic review and meta-analysis.</p><p><strong>Objective: </strong>Treatment of traumatic optic neuropathy (TON) has been a subject of debate for many decades due to the scarcity of evidence-based treatment protocols. This review compares surgical decompression (SD) and steroid therapy (ST) as treatment approaches in TON patients.</p><p><strong>Methods: </strong>A PRISMA-guided systematic review using PubMed, Embase, Ovid and Scopus databases was performed till the last search date of July 31st 2021. The outcome of interest was an improvement in visual acuity. A meta-analysis of the odds ratio was performed using a random-effect model and sub-group analysis based upon criteria for assessment of improvement in visual acuity.</p><p><strong>Results: </strong>Sixteen studies (including 1046 patients) were included in the review. The review could identify 590 patients treated with SD and 456 treated with ST. In addition, there was a second cohort of patients presenting with NLP (no light perception). A meta-analysis with a sub-group analysis revealed that there was statistically no significant difference between the two treatment approaches in terms of improvement in VA.</p><p><strong>Conclusions: </strong>There is no difference in treatment results of SD or ST for TON. Several treatment protocols and different criteria for assessing visual acuity led to difficulty in generating evidence for selecting the correct treatment approach.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87040928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-operative Scar Comparison With Supraorbital Eyebrow and Upper Blepharoplasty Approach in the Management of Zygomaticomaxillary Complex Fractures. 眶上眉与上睑成形术治疗颧颌复合体骨折的术后瘢痕比较。
IF 0.9 Pub Date : 2023-12-01 Epub Date: 2022-08-30 DOI: 10.1177/19433875221124406
Hamza H Mirza, Faheem Ahmed, Murtaza Rahber, Zahoor A Rana

Study design: A prospective randomized comparative study was conducted to evaluate the postsurgical scar with Supraorbital Eyebrow (SE) Approach and Upper Blepharoplasty (UB) Approach used for open reduction and internal fixation (ORIF) of zygomaticomaxillary complex (ZMC) fractures.

Objective: To evaluate and compare the post-operative scar using Vancouver Scar Scale (VSS) following ORIF of ZMC fractures with SE and UB approaches.

Methods: In this study, 88 patients with ZMC fractures requiring ORIF and meeting the inclusion criteria were recruited between 2019 and 2020. Patients were randomly divided into SE and UB group, 44 patients in each. Clinical and radiological assessment was done preoperatively and post-operative scar evaluation was carried out at different intervals over a period of 6 months using VSS. A blinded observer rated the scar.

Results: The results showed that after 6 months of surgery, all the 44 (100%) patients in UB group had a mild scar (VSS score 1-5), while in the SE group 34 (77.3%) patients had a mild scar (VSS score 1-5) and 10 (22.7%) had a moderate scar (VSS score 6-10). The difference between the 2 groups was statistically significant (P-value = .001).

Conclusions: The UB approach has been established to be superior to SE approach in terms of post-operative scar as the results were statistically significant. This study can be used to advocate more frequent use of UB approach as compared to the previously popular SE approach for the management of ZMC fractures.

研究设计:一项前瞻性随机对照研究,评估眶上眉(SE)入路和上睑成形术(UB)入路用于颧腋复合体(ZMC)骨折切开复位内固定(ORIF)的术后瘢痕。目的:应用温哥华疤痕评分法(VSS)评价和比较采用SE和UB入路的ZMC骨折ORIF术后疤痕。方法:本研究在2019年至2020年期间招募88例符合纳入标准的需要ORIF的ZMC骨折患者。患者随机分为SE组和UB组,每组44例。术前进行临床和影像学评估,术后在6个月的时间间隔内使用VSS对疤痕进行评估。一个盲目的观察者评价了伤疤。结果:手术6个月后,UB组44例(100%)患者均出现轻度瘢痕(VSS评分1-5分),SE组34例(77.3%)患者出现轻度瘢痕(VSS评分1-5分),10例(22.7%)患者出现中度瘢痕(VSS评分6-10分)。两组间差异有统计学意义(p值= 0.001)。结论:UB入路在术后瘢痕方面优于SE入路,结果具有统计学意义。与之前流行的SE入路相比,本研究可用于提倡更频繁地使用UB入路来治疗ZMC骨折。
{"title":"Post-operative Scar Comparison With Supraorbital Eyebrow and Upper Blepharoplasty Approach in the Management of Zygomaticomaxillary Complex Fractures.","authors":"Hamza H Mirza, Faheem Ahmed, Murtaza Rahber, Zahoor A Rana","doi":"10.1177/19433875221124406","DOIUrl":"10.1177/19433875221124406","url":null,"abstract":"<p><strong>Study design: </strong>A prospective randomized comparative study was conducted to evaluate the postsurgical scar with Supraorbital Eyebrow (SE) Approach and Upper Blepharoplasty (UB) Approach used for open reduction and internal fixation (ORIF) of zygomaticomaxillary complex (ZMC) fractures.</p><p><strong>Objective: </strong>To evaluate and compare the post-operative scar using Vancouver Scar Scale (VSS) following ORIF of ZMC fractures with SE and UB approaches.</p><p><strong>Methods: </strong>In this study, 88 patients with ZMC fractures requiring ORIF and meeting the inclusion criteria were recruited between 2019 and 2020. Patients were randomly divided into SE and UB group, 44 patients in each. Clinical and radiological assessment was done preoperatively and post-operative scar evaluation was carried out at different intervals over a period of 6 months using VSS. A blinded observer rated the scar.</p><p><strong>Results: </strong>The results showed that after 6 months of surgery, all the 44 (100%) patients in UB group had a mild scar (VSS score 1-5), while in the SE group 34 (77.3%) patients had a mild scar (VSS score 1-5) and 10 (22.7%) had a moderate scar (VSS score 6-10). The difference between the 2 groups was statistically significant (<i>P</i>-value = .001).</p><p><strong>Conclusions: </strong>The UB approach has been established to be superior to SE approach in terms of post-operative scar as the results were statistically significant. This study can be used to advocate more frequent use of UB approach as compared to the previously popular SE approach for the management of ZMC fractures.</p>","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86033536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms 多层螺旋CT、牙束CT及术中三维c型臂对面部颅骨区域有效辐射剂量的比较
Pub Date : 2023-11-10 DOI: 10.1177/19433875231213906
Sebastian Pietzka, Anne Grieser, Karsten Winter, Alexander Schramm, Marc Metzger, Wiebke Semper-Hogg, Michael Grunert, Marcel Ebeling, Andreas Sakkas, Frank Wilde
Study Design Experimental single-centre study of X-ray absorption using a phantom skull. Objective This experimental study aimed to compare the radiation doses of different 3D imaging devices used in maxillofacial surgery, including one Multidetector CT (MDCT), two Conebeam CT (CBCT) and four intraoperative 3D C-arms. Methods Thermoluminescent dosimeters (TLD) were used to determine the absorbed radiation in an Alderson-Rando phantom skull. The phantom skull was positioned in the before mentioned seven devices and a defined 3D facial skull image was acquired. Subsequently, the TLD’S were read out and the effective doses (ED) and the organ doses (OD) were calculated and compared. Results OD varied significantly between tissues as well as between the 3D X-ray devices. The OD of the 3D C-arms were significantly lower than those of all other devices. The OD of the CT, especially in the standard setting, was the highest. Only by special adjustments of the scan protocol regarding CMF requirements for traumatology, the MDCT could achieve almost equivalent doses as the two tested CBCT-scanners. The calculated effective doses were also lowest for the 3D C-arm devices (11.2 to 129.9 μSv). The ED of the MDCT were significant higher (284.52–844.97 μSv) than in all other devices. The ED of the CBCTs (173.7–184.9) were lower than for MDCT but still higher than those of the 3D C-arms. Conclusions Intraoperative imaging using 3D C-arm devices is an effective method to verify reduction results in maxillofacial surgery intraoperatively with significantly lower ED than postoperatively CBCT and MDCT imaging.
研究设计利用假颅骨对x射线吸收进行实验性单中心研究。目的比较1台多层螺旋CT (Multidetector CT, MDCT)、2台锥形束CT (Conebeam CT, CBCT)和4台术中三维c臂的放射剂量。方法采用热释光剂量仪(TLD)测定Alderson-Rando模型颅骨的吸收辐射。幻影颅骨定位在上述七个装置中,并获得定义的3D面部颅骨图像。随后,读取TLD,计算有效剂量(ED)和器官剂量(OD)并进行比较。结果不同组织间及不同三维x线设备间OD差异显著。3D c型臂的外径明显低于其他所有装置。CT的外径,特别是在标准设置下,是最高的。只有根据创伤学的CMF要求对扫描方案进行特殊调整,MDCT才能达到与两种被测试的cbct扫描仪几乎相同的剂量。三维c臂装置的计算有效剂量也最低(11.2 ~ 129.9 μSv)。MDCT的ED (284.52 ~ 844.97 μSv)显著高于其他所有装置。cbct的ED(173.7-184.9)低于MDCT,但仍高于3D c臂。结论术中三维c臂成像是验证颌面部手术复位效果的有效方法,术中ED明显低于术后CBCT和MDCT成像。
{"title":"Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms","authors":"Sebastian Pietzka, Anne Grieser, Karsten Winter, Alexander Schramm, Marc Metzger, Wiebke Semper-Hogg, Michael Grunert, Marcel Ebeling, Andreas Sakkas, Frank Wilde","doi":"10.1177/19433875231213906","DOIUrl":"https://doi.org/10.1177/19433875231213906","url":null,"abstract":"Study Design Experimental single-centre study of X-ray absorption using a phantom skull. Objective This experimental study aimed to compare the radiation doses of different 3D imaging devices used in maxillofacial surgery, including one Multidetector CT (MDCT), two Conebeam CT (CBCT) and four intraoperative 3D C-arms. Methods Thermoluminescent dosimeters (TLD) were used to determine the absorbed radiation in an Alderson-Rando phantom skull. The phantom skull was positioned in the before mentioned seven devices and a defined 3D facial skull image was acquired. Subsequently, the TLD’S were read out and the effective doses (ED) and the organ doses (OD) were calculated and compared. Results OD varied significantly between tissues as well as between the 3D X-ray devices. The OD of the 3D C-arms were significantly lower than those of all other devices. The OD of the CT, especially in the standard setting, was the highest. Only by special adjustments of the scan protocol regarding CMF requirements for traumatology, the MDCT could achieve almost equivalent doses as the two tested CBCT-scanners. The calculated effective doses were also lowest for the 3D C-arm devices (11.2 to 129.9 μSv). The ED of the MDCT were significant higher (284.52–844.97 μSv) than in all other devices. The ED of the CBCTs (173.7–184.9) were lower than for MDCT but still higher than those of the 3D C-arms. Conclusions Intraoperative imaging using 3D C-arm devices is an effective method to verify reduction results in maxillofacial surgery intraoperatively with significantly lower ED than postoperatively CBCT and MDCT imaging.","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of the Literature on the Current State of Periosteum-Mediated Craniofacial Bone Regeneration 骨膜介导颅面骨再生的文献综述
Pub Date : 2023-11-09 DOI: 10.1177/19433875231214068
Eyituoyo Okoturo
Study Design This is an article review on the current state of periosteum-mediated bone regeneration (PMBR). It is a known mandibular reconstruction option in children, and though poorly understood and unpredictable, the concerns of developmental changes to donor and recipient tissues shared by other treatment options are nonexistent. The definitive role of periosteum during bone regeneration remains largely unknown. Objective The objective is to review the literature on the clinical and molecular mechanism evidence of this event. Methods Our search methodology was modeled after the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Search strategies were categorized into search 1 for clinical evidence of mandibular regeneration and search 2 for gene expression review for craniofacial regeneration. The quality assessment of each publication was undertaken, and inclusion criteria comprise mandibular continuity defect for search 1 and use of gene expression assay propriety kit for search 2. Results 33 studies were selected for search 1 while four studies with non-human subjects were selected for search 2. Monitoring of PMBR onset was advised at 2 weeks post-operative, and the gene expression results showed an upregulation of genes responsible for angiogenesis, cytokine activities, and immune–inflammatory response in week 1 and skeletal development and signaling pathways in week 2. Conclusions The results suggest that young periosteum has a higher probability of PMBR than adult periosteum, and skeletal morphogenesis regulated by skeletal developmental genes and pathways may characterize the gene expression patterns of PMBR.
研究设计本文综述了骨膜介导骨再生(PMBR)的研究现状。这是一种已知的儿童下颌骨重建选择,尽管人们对其了解甚少且难以预测,但其他治疗方案对供体和受体组织发育变化的担忧并不存在。骨膜在骨再生中的决定性作用在很大程度上仍然未知。目的回顾有关该事件的临床和分子机制证据的文献。方法我们的搜索方法是按照PRISMA(系统评价和荟萃分析的首选报告项目)指南建模的。搜索策略分为搜索1下颌再生的临床证据和搜索2颅面再生的基因表达综述。对每份出版物进行质量评估,纳入标准包括搜索1的下颌连续性缺陷和使用基因表达测定专用试剂盒搜索2。结果检索1选择了33项研究,检索2选择了4项非人类研究。建议在术后2周监测PMBR的发生,基因表达结果显示,在第1周,负责血管生成、细胞因子活性和免疫炎症反应的基因上调,在第2周,负责骨骼发育和信号通路的基因上调。结论幼龄骨膜发生PMBR的概率高于成年骨膜,骨骼发育基因和途径调控的骨骼形态发生可能是PMBR基因表达模式的特征。
{"title":"Review of the Literature on the Current State of Periosteum-Mediated Craniofacial Bone Regeneration","authors":"Eyituoyo Okoturo","doi":"10.1177/19433875231214068","DOIUrl":"https://doi.org/10.1177/19433875231214068","url":null,"abstract":"Study Design This is an article review on the current state of periosteum-mediated bone regeneration (PMBR). It is a known mandibular reconstruction option in children, and though poorly understood and unpredictable, the concerns of developmental changes to donor and recipient tissues shared by other treatment options are nonexistent. The definitive role of periosteum during bone regeneration remains largely unknown. Objective The objective is to review the literature on the clinical and molecular mechanism evidence of this event. Methods Our search methodology was modeled after the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Search strategies were categorized into search 1 for clinical evidence of mandibular regeneration and search 2 for gene expression review for craniofacial regeneration. The quality assessment of each publication was undertaken, and inclusion criteria comprise mandibular continuity defect for search 1 and use of gene expression assay propriety kit for search 2. Results 33 studies were selected for search 1 while four studies with non-human subjects were selected for search 2. Monitoring of PMBR onset was advised at 2 weeks post-operative, and the gene expression results showed an upregulation of genes responsible for angiogenesis, cytokine activities, and immune–inflammatory response in week 1 and skeletal development and signaling pathways in week 2. Conclusions The results suggest that young periosteum has a higher probability of PMBR than adult periosteum, and skeletal morphogenesis regulated by skeletal developmental genes and pathways may characterize the gene expression patterns of PMBR.","PeriodicalId":46447,"journal":{"name":"Craniomaxillofacial Trauma & Reconstruction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135192014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Craniomaxillofacial Trauma & Reconstruction
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1