European Journal of Translational Myology最新文献

Bell's palsy is the most common cause of facial paralysis, affecting one in every 60 people in their lifetime. Transcutaneously applied selective electrical muscle stimulation could potentially accelerate recovery from Bell's palsy but this intervention remains controversial. Studies have shown benefit, but concerns for lack of efficacy and potential for worsening synkinesis remain. We performed a prospective controlled trial comparing outcomes at initial recovery and six months later with selective electrical muscle stimulation and usual physical therapy versus usual physical therapy alone in adults with acute Bell's palsy. Outcomes were facial function assessed with the House Brackman and eFACE scales. Outcomes were evaluated at discharge and six months after discharge. Discharge occurred when participants were judged to be fully recovered by their treating therapist and supervisor. 38 adults participated in the study. Participants in the electrical stimulation group achieved maximal recovery twice as fast as the control group (2.5 weeks versus 5.2 weeks) with no significant differences in facial function or synkinesis between groups at any time point. This study is the first human trial of electrical stimulation in Bell's palsy to follow patients 6 months from recovery and supports that selective electrical muscle stimulation accelerates recovery and does not increase synkinesis.

Duchenne muscular dystrophy is a highly progressive muscle wasting disease of early childhood and characterized by complex pathophysiological and histopathological changes in the voluntary contractile system, including myonecrosis, chronic inflammation, fat substitution and reactive myofibrosis. The continued loss of functional myofibres and replacement with non-contractile cells, as well as extensive tissue scarring and decline in tissue elasticity, leads to severe skeletal muscle weakness. In addition, dystrophic muscles exhibit a greatly diminished regenerative capacity to counteract the ongoing process of fibre degeneration. In normal muscle tissues, an abundant stem cell pool consisting of satellite cells that are localized between the sarcolemma and basal lamina, provides a rich source for the production of activated myogenic progenitor cells that are involved in efficient myofibre repair and tissue regeneration. Interestingly, the self-renewal of satellite cells for maintaining an essential pool of stem cells in matured skeletal muscles is increased in dystrophin-deficient fibres. However, satellite cell hyperplasia does not result in efficient recovery of dystrophic muscles due to impaired asymmetric cell divisions. The lack of expression of the full-length dystrophin isoform Dp427-M, which is due to primary defects in the DMD gene,  appears to affect key regulators of satellite cell polarity causing a reduced differentiation of myogenic progenitors, which are essential for myofibre regeneration. This review outlines the complexity of dystrophinopathy and describes the importance of the pathophysiological role of satellite cell dysfunction. A brief discussion of the bioanalytical usefulness of single cell proteomics for future studies of satellite cell biology is provided.

Diabetes is a chronic disease. Some complications can be prevented, their effects can be slowed down.  Sedentary lifestyle increases the risk of obesity and consequently the predisposition to diabetes II. The article aimed to demonstrate the positive and negative effects of exercise on active and sedentary diabetics and on pathophysiology, evaluating the effects after 3 and 6 months. The study involved 90 participants, both male and female, with type II diabetes, aged 45, divided into two groups: Group A (n=50, sedentary) and Group B (n=40, active). We evaluated anthropometric parameters, blood chemistry values, which are fundamental for the transversal evaluation of the results. In group A improvements were less noticeable than group B. The most improved parameter is blood sugar, Glycemic values and BMI. Cholesterol and Hb1Ac decreased but more slowly than previous parameters. The expectations of the study were, not only in recognizing the therapeutic and preventive powers of exercise, but above all in choosing to program a motor protocol after a team work between diabetologist, sports doctor and kinesiologist and/ or personal trainer. Physical activity is an additional therapy to insulin.

In recent years, wearable sensors and mHealth applications are becoming an important part for recording and monitoring health parameters. The aim is to characterize bibli-ometric indicators on scientific productivity in the use of smart bracelets according to scientific journal, study topic and publication trend. A bibliometric study was per-formed. The data extracted from the articles were: year of publication, name of the journal, language of publication, country, type of study and subject matter. A total of 45 studies were identified (21 cross-sectional and 24 experimental), of which 43 were published in English, one in Spanish and one in German. A total of 32 scientific journals published eight research topics related to smartwatch use [active living with 17 studies (37.8%), followed by stress and anxiety with 7 studies (15.6%), nanogenerators (batteries) with 6 studies (13.3%), computing with 5 studies (11.1%), chronic diseases 4 studies (8.9%), COVID propagation 3 studies (6.7%), energy expenditure 2 studies (4.4%) and occupational health 1 study (2.2%)]. The journal Sensors (Basel) published the most articles in the last 6 years (n=7, 16%). The scientific productivity of both study types reflects a positive trend (cross-sectional studies R2= 0.82 and in experimental studies R2= 0.76). A total of 45 cross-sectional and experimental studies using smart-watches were verified in eight different study topics. The most investigated category was active living and the journal that published the highest number of articles was the journal Sensors (Basel).

Euthanasia is the most important ethical challenges in the entire field of medicine. Various factors may influence the medical students' attitudes toward euthanasia, including personal beliefs, values, and personality traits. This research aimed at examining spiritual intelligence as a moderator of the relationship between openness to experience and attitude toward euthanasia. In this cross-sectional study, a total of 219 medical students (85 men and 134 women) in Zahedan, Iran, in 2022, were selected by convenience sampling method and evaluated using the socio-demographic information form (including age, gender, and medical education level), Spiritual Intelligence Self-Report Inventory, 24-item Brief HEXACO Inventory, and Euthanasia Attitude Scale, followed by using SPSS v25 for data analysis. The study results showed that openness to experience positively and spiritual intelligence negatively associated with attitude toward euthanasia. Also, the regression analysis revealed that spiritual intelligence had a moderating role in the relationship between openness to experience and attitude toward euthanasia. It seems that paying attention to personality differences and spiritual intelligence training among medical students can play an important role in changing their attitudes toward euthanasia.

We read the comment by Šarabon and Sašek (Eur J Transl Myol 11846, 2023 doi: 10.4081/ejtm.2023.11846) on our study on the electromyographic results during squat at high-altitude. Their highlighting of the factors that may have biased our results is commendable, despite they criticized our work as if it were a controlled laboratory study. We considered the limitations and argued our interpretation with caution. We found no changes in median frequency, frequency's slope and conduction velocity of EMG signals at high altitude, and a slight decrease of root mean square. We argued that our results may have been due to a preventative mechanism that compensates for relatively greater effort during a fatiguing strength test involving large muscle masses, or to cumulative exertional stress on the muscles. The authors of the comment themselves somehow agree with these interpretations. Guidelines for collecting, reporting and interpreting data from EMG to obtain original information on the neuromuscular system should be integrated with the effort to maintain as much as possible those field conditions that offer unique opportunities.

We read with particular interest the study by Rua et al. (Eur J Transl Myol 33 (3) 11637, 2023 doi: 10.4081/ejtm.2023.11637) on the electromyographic (EMG) activity of the quadriceps muscle during squat at high-altitude. It offers interesting insights into how neural factors might alter muscle function during a multi-joint low-intensity motor task with sustained contraction after trekking under hypoxic conditions. However, the methodological processes and procedures used in the study could bias the interpretation of the outcomes. Therefore, we outline the procedural considerations that should be taken into account in further studies aimed at investigating the potential changes in quadriceps EMG activity during the squat as a result of trekking at high-altitude.

Age-related muscle loss poses a significant health concern in an aging population. This study aimed to assess the impact of a home Full-Body in-Bed Gym protocol on quality of life, pain and risk of sarcopenia in elderly subjects. A total of 22 subjects with a median age of 71.90 years were included in the study. Patients participating in the Full-Body in-Bed Gym program, with a frequency of three times a week for two months, demonstrated a significant enhancement in their quality of life, as indicated by the 12-Item Short Form Health Survey (SF-12) Mental Component Summary (p = 0.04), and an improvement in pain levels (p = 0.03). Although not statistically significant, there was also an improvement in sarcopenia risk. Patients were given the freedom to decide whether to continue treatment after the evaluation of outcomes. Patient compliance with the exercise protocol over six months indicated its feasibility and sustainability, even in the long term. These findings suggest that the Full-Body in-Bed Gym protocol may play a valuable role in mitigating age-related muscle loss, emphasizing the importance of further investigation into such rehabilitation and prevention strategies.

This study aimed to evaluate the antimicrobial effect of hydro-alcoholic extract of apple (Malus domestica Borkh. Vs.golab, with and without ZnO nanoparticles) on Streptococcus Mutans bacterium compared to 0.2% Chlorhexidine, Persica and suspension of ZnO nanoparticles. Study samples were examined in the groups of apple hydro-alcoholic extract with and without addition of ZnO nanoparticles, a positive control group (Chlorhexidine 0.2%, Persica and suspension of ZnO nanoparticles), and a negative control group (distilled water). In this experiment, a concentration of 500 PPM of ZnO nanoparticles with a diameter of 0.4 nm was used. Agar diffusion method was used to determine the Minimum Inhibitory Concentration (MIC) of apple hydro-alcoholic extract with and without adding ZnO nanoparticles. The concentrations used were 200, 100, 50 and 25 mg/ml. ANOVA statistical test was used to compare the average in the study groups. According to our results, hydro-alcoholic extract of apples alone had no effect on the target bacteria in any of the concentrations. In the group of apple hydro-alcoholic extract with ZnO nanoparticles, the mean inhibition zone was 13 mm at a concentration of 25 mg/ml. 0.2% Chlorhexidine, Persica and suspension of ZnO nanoparticles was observed with the mean inhibition zone of 20 mm, 16 mm and 15 mm, respectively. Hydro-alcoholic extract of apple with addition of ZnO nanoparticles in concentration of 25mg/ml, had growth inhibitory effect on Streptococcus Mutans, but it was not remarkably efficient in comparison with Chlorhexidine.

This correspondence discusses a published article on the effects of physical activity on Long COVID fatigue. Confounding factors are possible and should be acknowledged. When managing Long COVID-19 fatigue, you need to worry about other possible causes of the problem.