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Prodromes and biological markers in schizophrenia: Importance for the dopamine, glutamate, and neurodevelopmental hypothesis 精神分裂症的前驱症状和生物学标记:多巴胺、谷氨酸和神经发育假说的重要性
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-10-04 DOI: 10.17711/sm.0185-3325.2022.033
J. Díaz-Sánchez, Héctor Solís-Chagoyán, G. Benítez-King
Background. Since schizophrenia is a multifactorial mental illness, a basic understanding of its etiological components improves its understanding, diagnosis, and the selection of therapeutic targets. Objective. To identify the prodromes and biological markers in schizophrenic or ultra-high risk (UHR) patients and elucidate their specificity. Method. Narrative review of relevant sources in English and Spanish in the Medline-PubMed database on minor physical abnormalities, cognitive abnormalities, neuroanatomical, and synaptic and cell changes present in schizophrenic patients and/or subjects with a high risk of developing schizophrenia Results. Patients with SZ and, to a lesser extent, UHR subjects present phenotypic and behavioral manifestations that correlate with underlying cell processes. The study of the latter makes it possible to characterize diagnostic biomarkers. At present, its clinical application is limited by factors such as poorly understood pathophysiology, lack of study models, homology with other psychiatric disorders, and the dearth of clinical trials conducted. Discussion and conclusion. Schizophrenia is the final manifestation of damage to prenatal and post-natal neurodevelopment and is reflected during the prodromal stage in early biological markers with clinical relevance. It is necessary to establish new study models that will increase knowledge to offer specific biomarkers for use in early clinical diagnosis.
背景。由于精神分裂症是一种多因素精神疾病,对其病因成分的基本了解有助于对其认识、诊断和治疗靶点的选择。目标。鉴定精神分裂症或超高危险(UHR)患者的前驱症状和生物学标志物,并阐明其特异性。方法。对Medline-PubMed数据库中有关轻微生理异常、认知异常、神经解剖、突触和细胞变化的相关英文和西班牙文资料进行叙事性回顾,这些变化存在于精神分裂症患者和/或发展为精神分裂症的高风险受试者中。SZ患者和较小程度的UHR患者表现出与潜在细胞过程相关的表型和行为表现。后者的研究使得表征诊断生物标志物成为可能。目前,其临床应用受到病理生理学认识不清、缺乏研究模型、与其他精神疾病同源性、缺乏临床试验等因素的限制。讨论与结论。精神分裂症是产前和产后神经发育受损的最终表现,在前驱阶段就反映在具有临床相关性的早期生物学标志物中。有必要建立新的研究模型,以增加知识,为早期临床诊断提供特定的生物标志物。
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引用次数: 0
Attachment styles predict personality traits according to a pilot study of patients with anxiety and mood disorders 根据一项针对焦虑和情绪障碍患者的初步研究,依恋类型可以预测人格特征
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-10-04 DOI: 10.17711/sm.0185-3325.2022.031
Victor Israel Cervera-Solís, Manuel Alejandro Muñoz Suárez, J. Cortés Sotres, José Octavio Hernández Lagunas, A. Díaz-Anzaldúa
Introduction. The mother and child attachment could have an important and long-lasting impact. An insecure attachment could lead to emotional development difficulties. It has been suggested that maternal care in infants is associated with personality. However, more studies in adults are needed. Objective. To determine if attachment styles in subjects with affective or anxiety disorders are associated with the expression of personality traits, and if this effect can be modulated by the presence of the short allele of the 5-HTTLPR polymorphism. Method. Our sample included 87 patients with mood or anxiety disorders. The NEO-PI-R questionnaire and the Adult Attachment questionnaire by Melero were used. Results. Insecure attachment styles were associated with a higher expression of neuroticism, and a lower expression of extraversion, conscientiousness, and agreeableness, especially in individuals with the most insecure attachment. An interaction was identified between the attachment style and the 5-HTTLPR genotype on the expression of agreeableness. Higher neuroticism, and lower extraversion and conscientiousness tended to be present in carriers of the S allele. Discussion and conclusion. There was a significant association between the attachment styles and the expression of neuroticism, extraversion, agreeableness, and conscientiousness-responsibility according to the Big Five Model. The short allele may be associated with the modulation of certain aspects of personality. Prevention strategies should be established to promote adequate attachments between infants and caregivers to avoid a possible risk factor for future maladaptive personality traits.
介绍。母子之间的依恋关系可能会产生重要而持久的影响。不安全的依恋会导致情感发展困难。有人认为,母婴护理与婴儿的个性有关。然而,需要对成人进行更多的研究。目标。确定情感障碍或焦虑障碍受试者的依恋类型是否与人格特征的表达相关,以及这种影响是否可以通过5-HTTLPR多态性短等位基因的存在来调节。方法。我们的样本包括87名患有情绪或焦虑障碍的患者。采用NEO-PI-R问卷和Melero成人依恋问卷。结果。不安全依恋类型与较高的神经质表达、较低的外向性、严谨性和宜人性表达相关,尤其是在最不安全依恋的个体中。依恋类型与5-HTTLPR基因型在亲和性表达上存在交互作用。高神经质,低外向性和尽责性倾向于存在于S等位基因携带者。讨论与结论。根据大五人格模型,依恋类型与神经质、外向性、宜人性和尽责性-责任感的表达有显著的相关性。短等位基因可能与人格某些方面的调节有关。应制定预防策略,以促进婴儿和照顾者之间的适当依恋,以避免未来适应不良人格特征的可能风险因素。
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引用次数: 0
Machine learning approaches to identify profiles and predictors of psychosocial discomfort among Italian college students 机器学习方法识别概况和预测心理社会不适的意大利大学生
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-10-04 DOI: 10.17711/sm.0185-3325.2022.028
C. Buizza, J. Dagani, C. Ferrari, Herald Cela, A. Ghilardi
Introduction. College students live a crucial period of transition from late adolescence to adulthood when they have to deal with important stressful tasks. Thus, university often represents a stressful environment, pushing students to cope with a high academic pressure. As a result, this period constitutes a sensitive age for the onset of mental disorders. Typically, students are not aware of the early signs of their own compromised mental health until symptoms aggravate to an overt disorder. Therefore, it is important to timely detect subthreshold symptoms mostly related to generic mental distress. Objective. First, to assess psychophysical well-being and mental distress among college students in northern Italy, and to detect predictors, among socio-demographic and academic characteristics, and risky drug use of these two outcomes. Method. The study involved 13,886 students who received an email explaining the purpose of the e-research. The questionnaires used were the General Health Questionnaire (GHQ-12), the University Stress Scale (USS), and a modified version of World Health Organization-ASSIST v3.0. Results. 3,754 students completed the web-survey. Students showed poor well-being and mental distress. The strongest predictor of mental distress and compromised well-being was physical health, followed by sex, study field, risky drug use, and academic performance concerns. Discussion and conclusion. This study shows that it is very important to promote in college students healthy behaviors in order to increase their physical exercise and reduce substance use. Moreover, it would be desirable to improve academic counselling facilities as an important front-line service to intercept mental health issues among young adults.
介绍。大学生正处于从青春期晚期到成年的关键过渡时期,他们必须处理重要的压力任务。因此,大学通常代表着一个充满压力的环境,迫使学生应对巨大的学术压力。因此,这一时期是精神疾病发病的敏感年龄。通常情况下,学生没有意识到自己的心理健康受损的早期迹象,直到症状加重到明显的障碍。因此,及时发现阈下症状是很重要的,这些症状大多与一般性精神困扰有关。目标。首先,评估意大利北部大学生的心理健康和心理困扰,并在社会人口统计学和学术特征中发现预测因素,以及这两种结果的危险药物使用。方法。这项研究涉及13886名学生,他们收到了一封解释电子研究目的的电子邮件。使用的问卷为一般健康问卷(GHQ-12)、大学压力量表(USS)和世界卫生组织assist v3.0修订版。结果:3754名学生完成了网络调查。学生表现出较差的幸福感和精神压力。最能预测精神压力和健康受损的因素是身体健康,其次是性别、学习领域、高风险药物使用和学习成绩问题。讨论与结论。本研究表明,促进大学生健康行为对于增加体育锻炼,减少物质使用具有重要意义。此外,最好改善学术咨询设施,将其作为阻断年轻人心理健康问题的重要一线服务。
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引用次数: 0
Intersection of public health, nutrition, and mental health: Challenges to progress 公共卫生、营养和心理健康的交叉:进步的挑战
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-10-04 DOI: 10.17711/sm.0185-3325.2022.027
S. Barquera
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引用次数: 0
Assessment of corona-phobia in university students with the COVID-19 Phobia Scale (C19P-S): A cross-sectional analysis 用COVID-19恐惧量表(C19P-S)评估大学生的冠状病毒恐惧:一项横断面分析
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-10-04 DOI: 10.17711/sm.0185-3325.2022.032
M. Salman, Z. Mustafa, Abdul Wahab Javaid, N. Shehzadi, Tauqeer Hussain Mallhi, Yusra Habib Khan, F. Masood, K. Hussain
Introduction. Disease phobia may impose distressing manifestations along with compromised quality of life, particularly in young age. COVID-19 caused substantial psychological concerns in general population which required the attention of health authorities to address the issue as soon as possible. Objective. This study was aimed to determine COVID-19 phobia in Pakistani youth during the current pandemic. Method. A cross-sectional study was conducted to ascertain the extent of fear of COVID-19 among university students in Lahore, Pakistan using the COVID-19 Phobia Scale (C19P-S). Psychological, somatic, social, and economic factors were ascertained among students. The relationship of demographics with the phobia score was determined through appropriate statistical tests. Result. This study included 374 students with a male preponderance (64.7%). The mean C19P-S score was 59.08 ± 14.44 (IQR: 50 - 70), with no significant difference among demographics except gender (male 57.65 ± 14.77 vs female 61.70 ± 13.47; p = .009). The mean psychological, psycho-somatic, economic, and social subscale scores were 19.59 ± 5.00 (25th percentile = 16 and 75th percentile = 24), 12.29 ± 4.56 (25th percentile = 10 and 75th percentile = 15), 11.22 ± 3.67 (25th percentile = 8 and 75th percentile = 14) and 15.97 ± 4.04 (25th percentile = 13.75 and 75th percentile = 19), respectively. Male students had a significantly lower score on social and psychological subscales than females (p #abr# .05). Discussion and conclusion. One fourth of the students achieved a fear score #cer# 70 on C19P-S. These results indicate the need of dire maneuvers for reducing corona-phobia among university students.
介绍。疾病恐惧症可能会带来痛苦的表现,并降低生活质量,特别是在年轻时。COVID-19在普通人群中引起了严重的心理担忧,这需要卫生当局的关注,以尽快解决这一问题。目标。本研究旨在确定当前大流行期间巴基斯坦青年的COVID-19恐惧症。方法。使用COVID-19恐惧症量表(C19P-S)进行了一项横断面研究,以确定巴基斯坦拉合尔大学生对COVID-19的恐惧程度。对学生的心理、身体、社会和经济因素进行了调查。通过适当的统计检验确定人口统计学与恐惧症得分的关系。结果。本研究包括374名学生,男性占优势(64.7%)。平均C19P-S评分为59.08±14.44 (IQR: 50 ~ 70),除性别外,其他人口统计学差异无统计学意义(男性57.65±14.77 vs女性61.70±13.47;P = .009)。心理、心身、经济和社会亚量表的平均得分分别为19.59±5.00(第25百分位= 16和75百分位= 24)、12.29±4.56(第25百分位= 10和75百分位= 15)、11.22±3.67(第25百分位= 8和75百分位= 14)和15.97±4.04(第25百分位= 13.75和75百分位= 19)。男学生的社会和心理分量表得分显著低于女学生(p #abr# 0.05)。讨论与结论。四分之一的学生在C19P-S测试中获得了70分左右的恐惧得分。这些结果表明,需要采取可怕的策略来减少大学生的冠状病毒恐惧症。
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引用次数: 1
Repercussions of the COVID-19 lockdown for autistic people in Mexico: The caregivers’ perspective COVID-19封锁对墨西哥自闭症患者的影响:护理人员的角度
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-08-15 DOI: 10.17711/sm.0185-3325.2022.022
Georgina Perez Liz, Andy Torres, A. Ramírez, Cecilia Montiel Nava
Introduction. The COVID-19 lockdown has posed new challenges for individuals with autism spectrum disorder (ASD), including service suspension and reductions in support. Objective. To explore the perspectives of caregivers on the impact of the COVID-19 lockdown on people with ASD in Mexico. Method. 126 caregivers from Mexico completed a survey on the impact of lockdown on people with ASD. Results. Suspension of at least one service was reported for 38.9% of subjects, with no significant association being found between symptom worsening and service administration modality. Discussion and conclusion. Service suspension for people with ASD in Mexico has been a side effect of the pandemic, negatively impacting their behavior. Results indicate that certain services could be remotely maintained and provided to individuals with ASD in underserved areas.
介绍。COVID-19封锁给自闭症谱系障碍(ASD)患者带来了新的挑战,包括服务暂停和支持减少。目标。探讨护理人员对COVID-19封锁对墨西哥ASD患者影响的看法。方法:来自墨西哥的126名护理人员完成了一项关于封锁对自闭症患者影响的调查。结果。38.9%的受试者至少暂停一项服务,症状恶化与服务给药方式之间未发现显著关联。讨论与结论。在墨西哥,暂停对自闭症患者的服务是疫情的副作用,对他们的行为产生了负面影响。结果表明,某些服务可以远程维护并提供给服务不足地区的ASD患者。
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引用次数: 1
Implications of the COVID-19 lockdown for the emotional well-being of the adult population in Mexico COVID-19封锁对墨西哥成年人情绪健康的影响
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-08-15 DOI: 10.17711/sm.0185-3325.2022.024
Consuelo Cervantes-Muñoz, J. Mora-Ríos, Teresa Saltijeral-Méndez, L. Ramos-Lira
Introduction. After several months of COVID-19 lockdown, addressing the implications related to the emotional distress and well-being of the population during confinement has become increasingly evident. Objective. To explore, through a lexicometric and content-based approach, the responses related to discomfort and emotional well-being during the first confinement due to the COVID-19 lockdown. Method. Subjects included 2,555 adults in Mexico, mainly women (78.3%), with an average age of 46. Data were drawn from an online survey published on social networks from June 3 to July 5, 2020. The open answers of the subjects about discomfort and emotional well-being during lockdown, together with suggestions to improve the handling of the pandemic, were analyzed using word frequency analysis (clouds) and thematic content analysis. Result. Findings highlighted the implications of lockdown, including loss of social interaction, teleworking and overexposure to the news, associated with discomfort. In turn, activities related to self-care, doing household repairs, and sharing activities with the family were linked to well-being. Discussion and conclusion. Findings show that time was a key factor to transition from well-being to boredom, where space and material resources played a preponderant role during confinement.
介绍。在COVID-19封锁几个月后,解决与封锁期间人口情绪困扰和福祉相关的影响变得越来越明显。目标。通过词汇计量学和基于内容的方法,探索因COVID-19封锁而首次禁闭期间与不适和情绪健康相关的反应。方法。研究对象包括2555名墨西哥成年人,主要是女性(78.3%),平均年龄46岁。数据来自2020年6月3日至7月5日在社交网络上发布的在线调查。利用词频分析(云)和主题内容分析,分析了受试者对封锁期间不适和情绪健康的公开回答,以及改善大流行处理的建议。结果。调查结果强调了封锁的影响,包括失去社交互动、远程工作和过度接触新闻,这些都与不适有关。反过来,与自我照顾、做家务修理和与家人分享活动有关的活动与幸福有关。讨论与结论。研究结果表明,时间是从幸福过渡到无聊的关键因素,其中空间和物质资源在禁闭期间发挥了主导作用。
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引用次数: 1
Doctoring and mothering during the SARS-COV2 pandemic: Characteristics of physicians-mothers during COVID-19 and their impact on mental health SARS-COV2大流行期间的医生和母亲:COVID-19期间医生母亲的特征及其对心理健康的影响
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-08-15 DOI: 10.17711/sm.0185-3325.2022.025
I. Vargas-Huicochea, S. Berenzon, S. A. Tafoya, Diana Guízar-Sánchez, N. Kelsall, A. Rodríguez-Machain, Atenea Lanz-Uribe
Introduction. During COVID-19, health workers faced increased stress accentuated by gender roles, such as motherhood. Objective. This study analyzed the characteristics of a group of physicians-mothers, its impact on mental health, and their experiences during this pandemic. Method. Mixed methods study using an online survey to investigate sociodemographic, family, emotional, and professional aspects, in addition to the personal experience of 537 doctors-mothers during the first stage of COVID-19. Results. Due to the pandemic, most of the participants changed their daily activities. The hours dedicated to professional work (HM = 5.08, p  #abr#  .0001), childcare (HM = 3.74, p  #abr#  .0001), and food planning and preparation (HM = -6.96, p  #abr#  .0001) were increased, while the hours dedicated to physical exercise (MH = 8.67, p  #abr#  .0001) and personal care (MH = 9.54, p  #abr#  .0001) decreased. It has been pointed out that this pandemic has generated a lack of well-defined spaces, resulting in multitasking. Fear and guilt were two common words in the speeches of the participants. Fear of getting sick and dying, or fear of infecting their families. Guilt at feeling that they did not play a good role either as doctors or as mothers. Most common psychological symptoms were insomnia, sadness or discouragement, and constant worry or tension. Discussion and conclusion. The pandemic evidenced and exacerbated both the disparities faced by these female doctors in the medical field, as well as the inequity in housework and home-care. The loss of boundaries between the public and the private showed the mothers-doctor struggling to reconcile their personal and professional life with substantial repercussions for their mental health.
介绍。在2019冠状病毒病期间,卫生工作者面临着性别角色(如母亲)加剧的压力。目标。这项研究分析了一组医生母亲的特征、对心理健康的影响以及她们在这次大流行期间的经历。方法。混合方法研究通过在线调查调查社会人口、家庭、情感和专业方面,以及537名医生母亲在COVID-19第一阶段的个人经历。结果。由于疫情,大多数参与者改变了他们的日常活动。从事专业工作(HM = 5.08, p #abr# .0001)、儿童保育(HM = 3.74, p #abr# .0001)和食物计划和准备(HM = -6.96, p #abr# .0001)的时间有所增加,而从事体育锻炼(HM = 8.67, p #abr# .0001)和个人护理(MH = 9.54, p #abr# .0001)的时间有所减少。有人指出,这次大流行病造成缺乏明确界定的空间,导致多任务处理。恐惧和内疚是参与者演讲中常见的两个词。害怕生病和死亡,或者害怕感染他们的家人。内疚的感觉,他们没有发挥良好的作用,无论是作为医生或母亲。最常见的心理症状是失眠、悲伤或沮丧、持续的担忧或紧张。讨论与结论。大流行病证明并加剧了这些女医生在医疗领域面临的不平等,以及家务和家庭护理方面的不平等。公共和私人之间界限的丧失表明,身为母亲的医生正在努力调和她们的个人生活和职业生活,这对她们的心理健康产生了重大影响。
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引用次数: 1
The SARS-COV2 pandemic: Changing the way we live SARS-COV2大流行:改变我们的生活方式
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-08-15 DOI: 10.17711/sm.0185-3325.2022.020
F. M. Moreno Sánchez
Adaptation to change is the way a species manages to survive the natural phenomena that jeopardize the existence of life. Late 2019 marked the start of a different type of natural disaster that threatened the lives of all human beings who watched what was happening incredulously, forcing them to change © 2022. Salud Mental.All Rights Reserved.
适应变化是一个物种设法在危及生命存在的自然现象中生存下来的方式。2019年底标志着一场不同类型的自然灾害的开始,这场自然灾害威胁着所有人的生命,他们难以置信地看着发生的事情,迫使他们改变©2022。祝您健康心理。版权所有。
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引用次数: 0
Health psychology on long COVID: Strategies based on NICE and WHO guidelines recommendations 长期COVID的健康心理学:基于NICE和世卫组织指南建议的策略
IF 1.3 4区 医学 Q4 PSYCHIATRY Pub Date : 2022-08-15 DOI: 10.17711/sm.0185-3325.2022.026
J. F. Mora-Romo
Background. The chronic aspect that begins to characterize long COVID appeals to the need for interventions proposed by institutions such as the World Health Organization (WHO) and the National Institute for Health and Care Excellence (NICE) to manage the disease, emphasizing behavioral change and self-care. Objective. To perform a narrative review of the psychological literature that offers intervention strategies in alignment with the recommendations of the long COVID management guidelines proposed by WHO and NICE. Method. MEDLINE, EBSCO, Google Scholar, SciELO, PsycINFO, PubMed, Cochrane, and CONRICYT databases were consulted, using Boolean operators and keywords for an exhaustive search. Results. The contributions of the studies were categorized into five intervention strategies based on WHO and NICE recommendation guidelines: Psychoeducation, Self-care, Support networks, Relaxation, and Goal setting. These are given a brief introduction and their relevance to the management of long COVID symptomatology is described. Discussion and conclusion. The persistent condition of COVID-19 symptoms makes it necessary to recognize that lifestyle changes must be made, primarily focused on health care and prevention of worsening disease sequelae. These lifestyle changes can be achieved through behavior modification, focusing on protective factors such as education, self-care, support networks, relaxation techniques and, setting appropriate goals.
背景。长期COVID开始表现出的慢性方面,呼吁世界卫生组织(世卫组织)和国家卫生与保健卓越研究所(NICE)等机构提出干预措施,以管理疾病,强调行为改变和自我保健。目标。对心理学文献进行叙述性审查,根据世卫组织和NICE提出的COVID管理长期指南的建议,提供干预策略。方法。参考MEDLINE, EBSCO, Google Scholar, SciELO, PsycINFO, PubMed, Cochrane和CONRICYT数据库,使用布尔运算符和关键字进行穷尽搜索。结果。根据WHO和NICE的推荐指南,这些研究的贡献被分为五种干预策略:心理教育、自我护理、支持网络、放松和目标设定。对这些进行了简要介绍,并描述了它们与长COVID症状管理的相关性。讨论与结论。COVID-19症状的持续状态使我们有必要认识到,必须改变生活方式,主要关注卫生保健和预防疾病后遗症恶化。这些生活方式的改变可以通过行为矫正来实现,注重保护因素,如教育、自我照顾、支持网络、放松技巧和设定适当的目标。
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引用次数: 0
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Salud Mental
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