Pub Date : 2023-10-01Epub Date: 2023-07-18DOI: 10.1177/20494637231190191
Huda Anshasi, Mohammad Saleh, Maysoon S Abdalrahim, Omar Shamieh
Purpose: Cancer-related pain (CRP) is a common and distressing symptom experienced by many patients receiving palliative care. The purpose of this trial was to evaluate the effectiveness of the progressive muscle relaxation (PMR) technique in reducing CRP in patients receiving palliative care.
Methods: A total of 148 patients diagnosed with cancer and receiving palliative care were randomly allocated to either an intervention or control group. The intervention group received a 4-week daily course of PMR technique, while the control group received only usual care. Data was collected using a demographic and clinical characteristics form, as well as the Brief Pain Inventory (BPI). Blind evaluations were conducted prior to the start of the intervention (T0), at the end of the 4-week PMR intervention (T1), and at 1-month follow-up (T2).
Results: The results of this trial demonstrated a significant decrease in pain intensity scores for the PMR group compared to the control group at both T1 and T2 (p < 0.05). Furthermore, the PMR group also exhibited significant improvements in pain interference with general activity, mood, relations with others, sleep, and enjoyment of life scores compared to the control group at both T1 and T2 (p < 0.05).
Conclusion: The results of this trial suggest that the PMR technique may be an effective intervention for reducing pain intensity and improving pain interference with life activities in cancer patients receiving palliative care. However, further research is needed to provide more robust evidence for the effectiveness of this intervention.Clinical trial registration number: NCT04436705. Registered at ClinicalTrials.gov.
{"title":"The effectiveness of progressive muscle relaxation technique in reducing cancer-related pain among palliative care patients: A randomized controlled trial.","authors":"Huda Anshasi, Mohammad Saleh, Maysoon S Abdalrahim, Omar Shamieh","doi":"10.1177/20494637231190191","DOIUrl":"10.1177/20494637231190191","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer-related pain (CRP) is a common and distressing symptom experienced by many patients receiving palliative care. The purpose of this trial was to evaluate the effectiveness of the progressive muscle relaxation (PMR) technique in reducing CRP in patients receiving palliative care.</p><p><strong>Methods: </strong>A total of 148 patients diagnosed with cancer and receiving palliative care were randomly allocated to either an intervention or control group. The intervention group received a 4-week daily course of PMR technique, while the control group received only usual care. Data was collected using a demographic and clinical characteristics form, as well as the Brief Pain Inventory (BPI). Blind evaluations were conducted prior to the start of the intervention (T0), at the end of the 4-week PMR intervention (T1), and at 1-month follow-up (T2).</p><p><strong>Results: </strong>The results of this trial demonstrated a significant decrease in pain intensity scores for the PMR group compared to the control group at both T1 and T2 (<i>p</i> < 0.05). Furthermore, the PMR group also exhibited significant improvements in pain interference with general activity, mood, relations with others, sleep, and enjoyment of life scores compared to the control group at both T1 and T2 (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The results of this trial suggest that the PMR technique may be an effective intervention for reducing pain intensity and improving pain interference with life activities in cancer patients receiving palliative care. However, further research is needed to provide more robust evidence for the effectiveness of this intervention.Clinical trial registration number: NCT04436705. Registered at ClinicalTrials.gov.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 1","pages":"501-509"},"PeriodicalIF":1.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10722108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48770377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-09-07DOI: 10.1177/20494637231201716
Roxaneh Zarnegar
{"title":"Behaviour change in clinicians: When the triple tell'em don't work.","authors":"Roxaneh Zarnegar","doi":"10.1177/20494637231201716","DOIUrl":"10.1177/20494637231201716","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 1","pages":"424-425"},"PeriodicalIF":1.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10722102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44947733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.1177/20494637231203856
David Cameron, Joanna Harrison, Shiva Tripathi, James Edward Hill
Chronic pain constitutes a significant burden to patients and healthcare systems. For many patients, the only option is to attempt to manage their pain within their daily lives. Here, we review evidence provided by three systematic reviews for the effect of diet and diet supplements on patients’ experience of chronic pain.
{"title":"Pain and diet: A summary of the evidence for the role of diet modification in chronic pain","authors":"David Cameron, Joanna Harrison, Shiva Tripathi, James Edward Hill","doi":"10.1177/20494637231203856","DOIUrl":"https://doi.org/10.1177/20494637231203856","url":null,"abstract":"Chronic pain constitutes a significant burden to patients and healthcare systems. For many patients, the only option is to attempt to manage their pain within their daily lives. Here, we review evidence provided by three systematic reviews for the effect of diet and diet supplements on patients’ experience of chronic pain.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.1177/20494637231202744
Rebecca McLoughlin, Jenna Love, Jared G Smith, Whitney Scott, Tim Noblet
Background Pain is the prominent feature of sickle cell disease (SCD) and negatively affects quality of life. Delivery of pain management programmes (PMPs) has been suggested in clinical guidelines for pain management in SCD; however, further evidence of the feasibility and effectiveness of PMPs in this population is needed. This study explored the feasibility of delivering a sickle cell pain management programme (SCPMP) for adults within a haemoglobinopathies service. Methods A single arm, repeated-measures observational design was used to determine feasibility of delivering the SCPMP at one study site. Primary feasibility outcomes were recruitment, completion of treatment and outcome measures, satisfaction, credibility and acceptability to participants. Secondary feasibility outcomes were treatment outcomes and processes, frequency of vaso-occlusive crisis (VOC) and healthcare utilisation. Results Four of five feasibility criteria were met. Annual recruitment of eight participants to a SCPMP was not achieved. Twenty-nine people began a SCPMP during the study period. Twenty-five (86.2%) participants attended ≥5/8 sessions and 21(84%) programme completers provided all end of programme questionnaires. Mean scores of >7 on ten-point scales were seen across satisfaction and credibility questions. At least moderate (Hedges g >0.5) effect sizes were seen in pre-post SCPMP measures of pain interference, anxiety, depression, self-efficacy, pain-related worry and acceptance. A small (Hedges g 0.4) effect size was seen in HRQoL. Following SCPMP attendance, mean frequency of self-reported VOC and hospital admissions reduced. Conclusions This study suggests that, given an adequate source of referrals, a SCPMP is feasible to deliver and appears acceptable and credible to participants. Exploration of influences on recruitment, such as barriers to group interventions, would be illuminating, prior to investigating feasibility of an adequately powered randomised-controlled trial.
疼痛是镰状细胞病(SCD)的显著特征，并对生活质量产生负面影响。疼痛管理方案(pmp)的交付已被建议在SCD疼痛管理的临床指南;然而，需要进一步证明PMPs在这一人群中的可行性和有效性。本研究探讨了在血红蛋白病服务中为成人提供镰状细胞疼痛管理方案(SCPMP)的可行性。方法采用单臂、重复测量观察设计来确定在一个研究地点递送SCPMP的可行性。主要可行性结果包括招募、治疗完成和结果测量、满意度、可信度和参与者的可接受性。次要可行性结果是治疗结果和过程、血管闭塞危象(VOC)的频率和医疗保健利用。结果符合5项可行性标准中的4项。没有实现每年为方案管理方案征聘8名参与者。在研究期间，29人开始了SCPMP。25名(86.2%)参与者参加了≥5/8次会议，21名(84%)项目完成者提供了所有项目结束时的问卷。满意度和可信度问题的平均得分为7分(满分为10分)。在SCPMP前后对疼痛干扰、焦虑、抑郁、自我效能、疼痛相关担忧和接受的测量中，至少可以看到中等(Hedges g >0.5)的效应量。HRQoL的效应值较小(Hedges g 0.4)。参加SCPMP后，自我报告VOC的平均频率和住院次数减少。结论:本研究表明，如果有足够的转诊来源，SCPMP是可行的，并且对参与者来说是可接受和可信的。在调查充分有力的随机对照试验的可行性之前，探索对招募的影响，如群体干预的障碍，将具有启发性。
{"title":"Evaluating the feasibility of delivering a pain management programme for adults living with sickle cell disease","authors":"Rebecca McLoughlin, Jenna Love, Jared G Smith, Whitney Scott, Tim Noblet","doi":"10.1177/20494637231202744","DOIUrl":"https://doi.org/10.1177/20494637231202744","url":null,"abstract":"Background Pain is the prominent feature of sickle cell disease (SCD) and negatively affects quality of life. Delivery of pain management programmes (PMPs) has been suggested in clinical guidelines for pain management in SCD; however, further evidence of the feasibility and effectiveness of PMPs in this population is needed. This study explored the feasibility of delivering a sickle cell pain management programme (SCPMP) for adults within a haemoglobinopathies service. Methods A single arm, repeated-measures observational design was used to determine feasibility of delivering the SCPMP at one study site. Primary feasibility outcomes were recruitment, completion of treatment and outcome measures, satisfaction, credibility and acceptability to participants. Secondary feasibility outcomes were treatment outcomes and processes, frequency of vaso-occlusive crisis (VOC) and healthcare utilisation. Results Four of five feasibility criteria were met. Annual recruitment of eight participants to a SCPMP was not achieved. Twenty-nine people began a SCPMP during the study period. Twenty-five (86.2%) participants attended ≥5/8 sessions and 21(84%) programme completers provided all end of programme questionnaires. Mean scores of >7 on ten-point scales were seen across satisfaction and credibility questions. At least moderate (Hedges g >0.5) effect sizes were seen in pre-post SCPMP measures of pain interference, anxiety, depression, self-efficacy, pain-related worry and acceptance. A small (Hedges g 0.4) effect size was seen in HRQoL. Following SCPMP attendance, mean frequency of self-reported VOC and hospital admissions reduced. Conclusions This study suggests that, given an adequate source of referrals, a SCPMP is feasible to deliver and appears acceptable and credible to participants. Exploration of influences on recruitment, such as barriers to group interventions, would be illuminating, prior to investigating feasibility of an adequately powered randomised-controlled trial.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136130832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-20DOI: 10.1177/20494637231202078
Arvind Kendurkar, Jack Wilson, Matthew Sunderland, Adrian Dunlop, Chris Hayes, Christina Marel, Katherine L Mills
Introduction There is emerging evidence that posttraumatic-stress disorder may have mediating effects in development of chronic-non-cancer-pain and opioid-use-disorder independently, but its impact on the development of opioid-use-disorder in people with chronic-non-cancer pain is still unclear. Objectives (i) Estimate the risk of opioid-use-disorder among individuals with chronic-non-cancer-pain and posttraumatic-stress disorder, relative to those with chronic-non-cancer-pain only, and (ii) identify potential correlates of opioid-use-disorder among people with chronic-non-cancer-pain and posttraumatic-stress disorder. Methods This systematic review was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Longitudinal, epidemiological, cohort, follow-up, retrospective, prospective and cross-sectional studies reporting measures of variance on the likelihood of developing opioid-use-disorder with posttraumatic-stress disorder among individuals with chronic-non-cancer-pain were identified from six-electronic databases (Medline, Embase, Evidence-based Medicine reviews, PsycINFO, Scopus and Web of Science) until December 2022. Results Three out of the four studies, which met the selection criteria for this analysis reported statistically significant positive association between risk of developing opioid-use-disorder with posttraumatic-stress disorder among chronic-non-cancer-pain cohort (unadjusted Relative-Risk range: 1.51–5.27) but this association was not evident in the fourth study (adjusted Relative-Risk: 0.96; statistically non-significant), when adjusted for sociodemographic variables. The increased risk was noted particularly with females and chronic musculoskeletal pain conditions. Conclusions Posttraumatic-stress disorder can increase the risk of development of opioid-use-disorder among people with chronic-non-cancer-pain and a better understanding of this relationship will help to predict and prevent the development of opioid-use-disorder and may also help in reducing the disability and burden associated with chronic-non-cancer-pain. Perspective This review quantifies the risk of developing opioid-use-disorder in the context of posttraumatic-stress disorder among individuals with chronic-non-cancer-pain. Awareness and subsequent practice change will reduce the increasing global burden associated with the chronic-non-cancer-pain.
越来越多的证据表明，创伤后应激障碍可能在慢性非癌性疼痛和阿片类药物使用障碍的发展中具有独立的中介作用，但其对慢性非癌性疼痛患者阿片类药物使用障碍的影响尚不清楚。(i)相对于仅患有慢性非癌症性疼痛和创伤后应激障碍的患者，估计慢性非癌症性疼痛和创伤后应激障碍患者中阿片类药物使用障碍的风险;(ii)确定慢性非癌症性疼痛和创伤后应激障碍患者中阿片类药物使用障碍的潜在相关性。方法本系统评价按照系统评价和荟萃分析指南的首选报告项目进行。从六个电子数据库(Medline、Embase、循证医学评论、PsycINFO、Scopus和Web of Science)中确定了截至2022年12月的纵向、流行病学、队列、随访、回顾性、前瞻性和横断面研究，报告了慢性非癌性疼痛患者发生阿片类药物使用障碍合并创伤后应激障碍可能性的方差测量。结果符合本分析选择标准的4项研究中有3项报告慢性非癌性疼痛队列中发生阿片类药物使用障碍与创伤后应激障碍的风险存在统计学显著正相关(未调整相对风险范围:1.51-5.27)，但在第4项研究中这种关联不明显(调整相对风险:0.96;统计上不显著)，当调整了社会人口变量。这种风险的增加在女性和慢性肌肉骨骼疼痛患者中尤为明显。结论创伤后应激障碍可增加慢性非癌性疼痛患者发生阿片类药物使用障碍的风险，更好地了解这一关系将有助于预测和预防阿片类药物使用障碍的发生，并有助于减少与慢性非癌性疼痛相关的残疾和负担。本综述量化了慢性非癌性疼痛患者在创伤后应激障碍背景下发生阿片类药物使用障碍的风险。认识和随后的实践改变将减轻与慢性非癌性疼痛相关的日益增加的全球负担。
{"title":"Is post-traumatic stress disorder a risk factor for development of opioid use disorder among individuals with chronic non-cancer pain? A systematic review","authors":"Arvind Kendurkar, Jack Wilson, Matthew Sunderland, Adrian Dunlop, Chris Hayes, Christina Marel, Katherine L Mills","doi":"10.1177/20494637231202078","DOIUrl":"https://doi.org/10.1177/20494637231202078","url":null,"abstract":"Introduction There is emerging evidence that posttraumatic-stress disorder may have mediating effects in development of chronic-non-cancer-pain and opioid-use-disorder independently, but its impact on the development of opioid-use-disorder in people with chronic-non-cancer pain is still unclear. Objectives (i) Estimate the risk of opioid-use-disorder among individuals with chronic-non-cancer-pain and posttraumatic-stress disorder, relative to those with chronic-non-cancer-pain only, and (ii) identify potential correlates of opioid-use-disorder among people with chronic-non-cancer-pain and posttraumatic-stress disorder. Methods This systematic review was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Longitudinal, epidemiological, cohort, follow-up, retrospective, prospective and cross-sectional studies reporting measures of variance on the likelihood of developing opioid-use-disorder with posttraumatic-stress disorder among individuals with chronic-non-cancer-pain were identified from six-electronic databases (Medline, Embase, Evidence-based Medicine reviews, PsycINFO, Scopus and Web of Science) until December 2022. Results Three out of the four studies, which met the selection criteria for this analysis reported statistically significant positive association between risk of developing opioid-use-disorder with posttraumatic-stress disorder among chronic-non-cancer-pain cohort (unadjusted Relative-Risk range: 1.51–5.27) but this association was not evident in the fourth study (adjusted Relative-Risk: 0.96; statistically non-significant), when adjusted for sociodemographic variables. The increased risk was noted particularly with females and chronic musculoskeletal pain conditions. Conclusions Posttraumatic-stress disorder can increase the risk of development of opioid-use-disorder among people with chronic-non-cancer-pain and a better understanding of this relationship will help to predict and prevent the development of opioid-use-disorder and may also help in reducing the disability and burden associated with chronic-non-cancer-pain. Perspective This review quantifies the risk of developing opioid-use-disorder in the context of posttraumatic-stress disorder among individuals with chronic-non-cancer-pain. Awareness and subsequent practice change will reduce the increasing global burden associated with the chronic-non-cancer-pain.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136373247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-14DOI: 10.1177/20494637231188306
Claire Austen, Drusilla Redman, Matteo Martini
Introduction Playing-related musculoskeletal pain is highly prevalent among classical music students, affecting them physically and psychologically. Unlike athletes or dancers, musicians’ pain often goes untreated due to stigma and lack of specialised healthcare. While warm-up exercises are common practice in sports and dance, there is a lack of empirical research regarding physical warm-ups for musicians’ pain. This study aimed to investigate the effects of a 2-week daily warm-up exercise intervention on conservatoire students’ pain intensity, interference and psychological distress, at day 0 and after 2 weeks. Methods Two groups were considered: an exercise ( n = 9) and a waitlist control ( n = 7) group. Data were collected using online Qualtrics surveys at three different stages. Results 2 × 2 mixed ANOVAs indicated no significant effects on any of the outcome variables. However, when controlling for sleep, anxiety, depression and physical activity, the analyses revealed a significantly greater decrease in pain intensity in the exercise group compared to the control. In addition, bivariate correlations indicated that pain interference, anxiety and depression delta scores were significantly correlated for the exercise but not the control group. Anxiety and pain intensity delta scores were significantly correlated in both groups. Conclusions These findings suggest that daily warm-up exercises have the potential to reduce musicians’ pain intensity but only if certain variables are factored in. This pilot study highlights the multifactorial nature of musicians’ pain and unveils the role that mood, sleep and physical activity level may have when assessing the efficacy of interventions based on warm-up exercises.
{"title":"Warm-up exercises reduce music conservatoire students’ pain intensity when controlling for mood, sleep and physical activity: A pilot study","authors":"Claire Austen, Drusilla Redman, Matteo Martini","doi":"10.1177/20494637231188306","DOIUrl":"https://doi.org/10.1177/20494637231188306","url":null,"abstract":"Introduction Playing-related musculoskeletal pain is highly prevalent among classical music students, affecting them physically and psychologically. Unlike athletes or dancers, musicians’ pain often goes untreated due to stigma and lack of specialised healthcare. While warm-up exercises are common practice in sports and dance, there is a lack of empirical research regarding physical warm-ups for musicians’ pain. This study aimed to investigate the effects of a 2-week daily warm-up exercise intervention on conservatoire students’ pain intensity, interference and psychological distress, at day 0 and after 2 weeks. Methods Two groups were considered: an exercise ( n = 9) and a waitlist control ( n = 7) group. Data were collected using online Qualtrics surveys at three different stages. Results 2 × 2 mixed ANOVAs indicated no significant effects on any of the outcome variables. However, when controlling for sleep, anxiety, depression and physical activity, the analyses revealed a significantly greater decrease in pain intensity in the exercise group compared to the control. In addition, bivariate correlations indicated that pain interference, anxiety and depression delta scores were significantly correlated for the exercise but not the control group. Anxiety and pain intensity delta scores were significantly correlated in both groups. Conclusions These findings suggest that daily warm-up exercises have the potential to reduce musicians’ pain intensity but only if certain variables are factored in. This pilot study highlights the multifactorial nature of musicians’ pain and unveils the role that mood, sleep and physical activity level may have when assessing the efficacy of interventions based on warm-up exercises.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134911003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.1177/20494637231201502
Márcia Pitrez Santos, Francisco Lemos, Joana Gomes, José Manuel Romão, Dalila Veiga
Introduction Peripheral neuropathic pain (PNP) is one of the most challenging diseases to treat with a significant negative impact on the patients’ health-related quality of life (HRQoL). Capsaicin 8% patch has arisen in the last decades as an alternative to oral drugs in the treatment of PNP with fewer side effects and promising results in efficacy. Objectives This work aims to evaluate the effectiveness of the topical application of capsaicin in PNP and its impact on patients’ HRQoL based on the use of capsaicin in a tertiary hospital of Oporto. Methods This study included 100 patients with localized PNP with poor pain control and without improvement with previous treatments that were treated at least once with an 8% capsaicin patch. Effectiveness on pain relief, number of treatments needed, safety and impact on HRQoL were assessed through a set of questionnaires. Results Regarding the aetiology of PNP, 67.6% ( N = 46) have post-surgery or trauma induced PNP with 64.7% ( N = 44) of patients reporting pain in the lower limb. After the treatment, 30.9% ( N = 21) felt minimally improved, 22.1 ( N = 15) felt much improved and 13.2 ( N = 9) felt very much improved. On a scale from 1 to 10, in the week prior to the survey, the median intensity of pain was 6 and the median interference in quality of life was 7. The majority of patients still report limitations in mobility and daily activities and moderate pain. Conclusion Capsaicin 8% patch is effective in PNP treatment at least in the short term. Repeated applications may be important for long-term analgesia. The low systemic dose and few side effects mean that the treatment is generally well tolerated by patients. Due to the analgesic effect, capsaicin can improve the HRQoL of patients with PNP.
{"title":"Topical capsaicin 8% patch in peripheral neuropathic pain: Efficacy and quality of life","authors":"Márcia Pitrez Santos, Francisco Lemos, Joana Gomes, José Manuel Romão, Dalila Veiga","doi":"10.1177/20494637231201502","DOIUrl":"https://doi.org/10.1177/20494637231201502","url":null,"abstract":"Introduction Peripheral neuropathic pain (PNP) is one of the most challenging diseases to treat with a significant negative impact on the patients’ health-related quality of life (HRQoL). Capsaicin 8% patch has arisen in the last decades as an alternative to oral drugs in the treatment of PNP with fewer side effects and promising results in efficacy. Objectives This work aims to evaluate the effectiveness of the topical application of capsaicin in PNP and its impact on patients’ HRQoL based on the use of capsaicin in a tertiary hospital of Oporto. Methods This study included 100 patients with localized PNP with poor pain control and without improvement with previous treatments that were treated at least once with an 8% capsaicin patch. Effectiveness on pain relief, number of treatments needed, safety and impact on HRQoL were assessed through a set of questionnaires. Results Regarding the aetiology of PNP, 67.6% ( N = 46) have post-surgery or trauma induced PNP with 64.7% ( N = 44) of patients reporting pain in the lower limb. After the treatment, 30.9% ( N = 21) felt minimally improved, 22.1 ( N = 15) felt much improved and 13.2 ( N = 9) felt very much improved. On a scale from 1 to 10, in the week prior to the survey, the median intensity of pain was 6 and the median interference in quality of life was 7. The majority of patients still report limitations in mobility and daily activities and moderate pain. Conclusion Capsaicin 8% patch is effective in PNP treatment at least in the short term. Repeated applications may be important for long-term analgesia. The low systemic dose and few side effects mean that the treatment is generally well tolerated by patients. Due to the analgesic effect, capsaicin can improve the HRQoL of patients with PNP.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135826322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To evaluate the efficacy of conventional and novel non-pharmacologic, non-invasive therapeutic interventions in physiotherapy for the treatment of phantom limb pain (PLP) in post-amputee patients. Methods A systematic search for the articles was conducted in multiple electronic databases such as PUBMED, Google Scholar, EMBASE, Cochrane library and Physiotherapy Evidence Database (PEDro), following the PRISMA method and only published articles from the last 12 years (2010–2022) evaluating the efficacy of different physiotherapy interventions for the treatment of PLP in post-amputee patients were included. The methodological quality and risk of bias of the articles were assessed and evaluated by two independent reviewers using the PEDro scale, Methodological index for non-randomized studies scale (MINORS), and Cochrane collaboration’s assessment tool. Result A total of 1840 articles were identified, out of which 17 articles (11 RCTs and 6 pilot studies) were ultimately chosen after the full-text screening. After reviewing the articles, evidence identified in RCTs and pilot studies indicates towards significant improvement in reducing the severity of PLP in post-amputee patients by using different physiotherapy interventions. Conclusion and discussion Physiotherapy interventions with advance modalities and exercises can be used to increase the overall effectiveness of the treatment and to reduce the severity of phantom limb pain in post-amputee patients. However, due to the lack of consistent evidence for a given intervention, it becomes even more difficult to reach a majority consensus as to which intervention better assess all the mechanism of PLP thereby alleviating the problem of PLP in post-amputee patients. Therefore, more rigorous randomized controlled trials will be required in the future to reach a conclusion.
{"title":"Physiotherapy: A potential and novel treatment approach for phantom limb pain in post-amputee patients – A systematic review","authors":"Sunny Gautam, Adarsh Kumar Srivastav, Digvijay Sharma","doi":"10.1177/20494637231197002","DOIUrl":"https://doi.org/10.1177/20494637231197002","url":null,"abstract":"Objective To evaluate the efficacy of conventional and novel non-pharmacologic, non-invasive therapeutic interventions in physiotherapy for the treatment of phantom limb pain (PLP) in post-amputee patients. Methods A systematic search for the articles was conducted in multiple electronic databases such as PUBMED, Google Scholar, EMBASE, Cochrane library and Physiotherapy Evidence Database (PEDro), following the PRISMA method and only published articles from the last 12 years (2010–2022) evaluating the efficacy of different physiotherapy interventions for the treatment of PLP in post-amputee patients were included. The methodological quality and risk of bias of the articles were assessed and evaluated by two independent reviewers using the PEDro scale, Methodological index for non-randomized studies scale (MINORS), and Cochrane collaboration’s assessment tool. Result A total of 1840 articles were identified, out of which 17 articles (11 RCTs and 6 pilot studies) were ultimately chosen after the full-text screening. After reviewing the articles, evidence identified in RCTs and pilot studies indicates towards significant improvement in reducing the severity of PLP in post-amputee patients by using different physiotherapy interventions. Conclusion and discussion Physiotherapy interventions with advance modalities and exercises can be used to increase the overall effectiveness of the treatment and to reduce the severity of phantom limb pain in post-amputee patients. However, due to the lack of consistent evidence for a given intervention, it becomes even more difficult to reach a majority consensus as to which intervention better assess all the mechanism of PLP thereby alleviating the problem of PLP in post-amputee patients. Therefore, more rigorous randomized controlled trials will be required in the future to reach a conclusion.","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-07-17DOI: 10.1177/20494637231190866
Amanda C de C Williams
{"title":"Dubious data and contamination of the research literature on pain.","authors":"Amanda C de C Williams","doi":"10.1177/20494637231190866","DOIUrl":"10.1177/20494637231190866","url":null,"abstract":"","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 4","pages":"328-329"},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01Epub Date: 2023-04-20DOI: 10.1177/20494637231172496
Maysoon S Abdalrahim, Khaldoun M Hamdan, Abeer M Shaheen
Background: The importance and efficacy of Preemptive analgesia in reducing pain for patients undergoing painful procedures still debatable and seldom investigated. The aim of this study was to describe intensive care nurses' perception of the importance of pain assessment and Preemptive analgesia prior painful procedures in critical care settings in Jordan.
Method: A cross-sectional descriptive design was used. The sample consisted of 300 registered nurses recruited from 22 intensive care units in Jordan. The data was gathered using a self-administered questionnaire.
Results: The results showed that nurses considered pain assessment moderately and extremely important for surgical (n = 263, 87.7%), burn (n = 261, 87%), and trauma patients (n = 256, 85.3%). The majority of nurses rated pain assessment as moderately to extremely important for invasive line placement 80.3%, wound care 78.3%, and drain removal 69%. Nurses assessed the need for Preemptive analgesia more frequently before wound care 70.7%, and before invasive line placement 69.7%. Nurses perceived pain assessment for Preemptive analgesia as less priority for unconscious patients.
Conclusion: Effective assessment and management of pain for critically ill patients is mandatory. Thus, it is important to improve nurses' knowledge regarding the Preemptive analgesia and its effects in relieving post-procedural pain in critically ill patient. It is recommended to ensure proper clinical training on how to assess critically ill patients and auditing system.
{"title":"Importance of preemptive analgesia and pain assessment as perceived by intensive care unit nurses.","authors":"Maysoon S Abdalrahim, Khaldoun M Hamdan, Abeer M Shaheen","doi":"10.1177/20494637231172496","DOIUrl":"10.1177/20494637231172496","url":null,"abstract":"<p><strong>Background: </strong>The importance and efficacy of Preemptive analgesia in reducing pain for patients undergoing painful procedures still debatable and seldom investigated. The aim of this study was to describe intensive care nurses' perception of the importance of pain assessment and Preemptive analgesia prior painful procedures in critical care settings in Jordan.</p><p><strong>Method: </strong>A cross-sectional descriptive design was used. The sample consisted of 300 registered nurses recruited from 22 intensive care units in Jordan. The data was gathered using a self-administered questionnaire.</p><p><strong>Results: </strong>The results showed that nurses considered pain assessment moderately and extremely important for surgical (<i>n</i> = 263, 87.7%), burn (<i>n</i> = 261, 87%), and trauma patients (<i>n</i> = 256, 85.3%). The majority of nurses rated pain assessment as moderately to extremely important for invasive line placement 80.3%, wound care 78.3%, and drain removal 69%. Nurses assessed the need for Preemptive analgesia more frequently before wound care 70.7%, and before invasive line placement 69.7%. Nurses perceived pain assessment for Preemptive analgesia as less priority for unconscious patients.</p><p><strong>Conclusion: </strong>Effective assessment and management of pain for critically ill patients is mandatory. Thus, it is important to improve nurses' knowledge regarding the Preemptive analgesia and its effects in relieving post-procedural pain in critically ill patient. It is recommended to ensure proper clinical training on how to assess critically ill patients and auditing system.</p>","PeriodicalId":46585,"journal":{"name":"British Journal of Pain","volume":"17 4","pages":"400-407"},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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