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Prehabilitation: The underutilised weapon for chronic pain management. 预康复:未被充分利用的慢性疼痛治疗武器。
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 Epub Date: 2024-04-29 DOI: 10.1177/20494637241250239
Lydia V Tidmarsh, Richard Harrison, Katherine A Finlay

Objective: Prehabilitation encompasses preparatory clinical intervention(s) delivered during the period between diagnosis and treatment commencement. Despite widespread successful usage preoperatively, psychological prehabilitation is neglected in outpatient chronic pain management. Although pain management waitlists are associated with treatment attrition and psychological and physical decline, this time window is underutilised in preventing escalation. Waitlists present an under-explored opportunity to 'prehabilitate' patients waiting for treatment. This topical review aimed to: (1) examine the effectiveness of psychological prehabilitation for pain services; (2) evaluate the psychological and physical decline associated with waiting for pain management; (3) highlight key psychological prehabilitative targets for increasing treatment engagement; (4) promote pain management psychological prehabilitation within personalised pain medicine, building recommendations for future interventions.

Methods: Studies regarding the impact of waitlists and prehabilitation for chronic pain were reviewed.

Results: Findings demonstrated that the psychological constructs of patient expectations, health locus of control, self-efficacy and pain catastrophizing dynamically influence attrition, treatment engagement and outcomes while waiting. These constructs are amenable to change, emphasising their potential utility within a targeted waitlist intervention.

Conclusions: Prehabilitating chronic pain patients towards treatment engagement could circumvent cycles of failed treatment seeking, preventing psychological and physical decline, and reducing healthcare utilisation. Utilising the waitlist to identify psychosocial risk factors (external health locus of control, low self-efficacy and high pain catastrophizing) would identify who requires additional support to prevent increased risk of treatment failure, enhancing personalised care before prescribed treatment is accessed. This review cements the urgent need for pain services to engage proactively with prehabilitation innovation.

目的:术前康复包括从诊断到开始治疗期间的准备性临床干预。尽管术前心理康复治疗被广泛应用,但在门诊慢性疼痛治疗中却被忽视。尽管疼痛治疗等待名单与治疗流失、心理和生理衰退有关,但这一时间窗口在防止治疗升级方面却未得到充分利用。候诊名单为等待治疗的患者提供了 "预康复 "的机会。本专题综述旨在(1)研究疼痛服务心理康复的有效性;(2)评估与等待疼痛治疗相关的心理和生理衰退;(3)强调提高治疗参与度的关键心理康复目标;(4)在个性化疼痛医学中促进疼痛治疗心理康复,为未来的干预措施提供建议:方法:回顾了有关慢性疼痛等待名单和预康复的影响的研究:研究结果表明,患者期望、健康控制点、自我效能感和疼痛灾难化等心理结构动态地影响着等待期间的流失、治疗参与度和治疗结果。这些心理结构易于改变,强调了它们在有针对性的候诊干预中的潜在作用:对慢性疼痛患者进行参与治疗前的康复训练,可以避免寻求治疗失败的循环,防止心理和生理衰退,减少医疗保健的使用。利用候诊清单来识别心理社会风险因素(外部健康控制定位、低自我效能感和高疼痛灾难化),可以确定哪些患者需要额外支持以防止治疗失败风险的增加,从而在接受处方治疗前加强个性化护理。本综述强调了疼痛服务部门主动参与康复前创新的迫切需要。
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引用次数: 0
The interaction between psychological factors and conditioned pain modulation. 心理因素与条件性疼痛调节之间的相互作用。
IF 1.5 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 Epub Date: 2024-06-19 DOI: 10.1177/20494637241263306
Kristian Kjær-Staal Petersen
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引用次数: 0
Experience of compassion-based practice in mindfulness for health for individuals with persistent pain. 以同情心为基础,为持续疼痛者提供正念保健实践的经验。
IF 1.5 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 Epub Date: 2024-02-23 DOI: 10.1177/20494637241232555
Callum Gray, Fergal Jones, Alessio Agostinis, Julia Morris

Purpose of the study: Research indicates that acquiring compassion is an integral part to positive outcomes to Mindfulness-based interventions (MBI), yet there is both theoretic and empirical literature suggesting that people with persistent pain are more likely to experience challenges and distress when engaging compassion-based practices. Mindfulness for Health is a standardised MBI for people with persistent pain and health conditions. This study sought to explore the positive, neutral and difficult experiences of compassion-based practice and meditation for participants in Mindfulness for Health to further understand implications and risks for participants of MBI's.

Method and design: A qualitative design using Interpretative Phenomenological Analysis was applied to explore how participants understood of the experience of compassion-based practice and the meaning they gave to it. Eight participants who had completed the Mindfulness for Health from four separate groups were interviewed about their experience.

Results: Five master themes were identified 'turning away from self-with-pain', 'self-with-pain experienced as shameful', 'facilitating change', 'turning towards self-with-pain', and 'accepting self'. Participants identified both perceived positive changes and difficult emotional experiences during the meditation practice, which they related to the context of compassion in their past and present life.

Conclusions: Developing compassion is an important part of Mindfulness for Health, which is salient for participants as both a challenging and potentially valuable experience. Acquisition of mindfulness skills, supporting group dynamics and modelling compassion are understood as helpful in overcoming personal barriers and challenging experiences. Further research is needed to understand processes involved and explore the experience of non-completers.

研究目的:研究表明,获得同情心是正念干预(MBI)取得积极成果不可或缺的一部分,但有理论和实证文献表明,持续性疼痛患者在参与以同情心为基础的实践时,更有可能遇到挑战和困扰。健康正念 "是一种针对持续性疼痛和健康状况患者的标准化 MBI。本研究旨在探索 "健康正念 "参与者在基于同情心的练习和冥想中的积极、中性和困难体验,以进一步了解 MBI 对参与者的影响和风险:采用解释性现象学分析法进行定性设计,探索参与者如何理解以同情为基础的练习体验以及他们赋予这种体验的意义。来自四个不同小组的八名完成了 "健康正念 "课程的参与者接受了关于其经历的访谈:结果:确定了五个主主题:"远离自我疼痛"、"自我疼痛是可耻的"、"促进改变"、"转向自我疼痛 "和 "接受自我"。参与者在冥想练习中发现了积极的变化和困难的情绪体验,并将其与过去和现在生活中的慈悲背景联系起来:培养慈悲心是 "健康正念 "的重要组成部分,这对参与者来说既是一种挑战,也是一种潜在的宝贵经验。获得正念技能、支持小组动力和树立慈悲榜样被认为有助于克服个人障碍和挑战性经历。需要进一步开展研究,以了解相关过程并探索未完成者的经历。
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引用次数: 0
A rapid systematic review of breakthrough pain definitions and descriptions 突破性疼痛定义和描述的快速系统回顾
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-25 DOI: 10.1177/20494637231208093
K. Greenfield, D. Schoth, Richard Hain, Simon Bailey, Christine Mott, Dilini Rajapakse, Emily Harrop, Kate Renton, Anna-Karenia Anderson, Bernie Carter, Margaret Johnson, C. Liossi
Breakthrough pain is common in life-limiting conditions and at end-of-life. Despite over 30 years of study, there is little consensus regarding the definition and characteristics of breakthrough pain. This study aims to update and expand a 2010 systematic review by Haugen and colleagues to identify (1) all definitions of breakthrough pain and (2) all descriptions and classifications of breakthrough pain reported by patients, caregivers, clinicians, and experts. This rapid systematic review followed the Cochrane Rapid Review Methods Group guidelines. A protocol is published on PROSPERO (CRD42019155583). CINAHL, MEDLINE, PsycINFO, and the Web of Science were searched for breakthrough pain terms from the inception dates of each database to 26th August 2022. We identified 65 studies that included data on breakthrough pain definitions, descriptions, or classifications from patients ( n = 30), clinicians ( n = 6), and experts ( n = 29), but none with data from caregivers. Most experts proposed that breakthrough pain was a sudden, severe, brief pain occurring in patients with adequately controlled mild-moderate background pain. However, definitions varied and there was no consensus. Pain characteristics were broadly similar across studies though temporal factors varied widely. Experts classified breakthrough pain into nociceptive, neuropathic, visceral, somatic, or mixed types. Patients with breakthrough pain commonly experienced depression, anxiety, and interference with daily life. Despite ongoing efforts, there is still no consensus on the definition of breakthrough pain. A compromise is needed on breakthrough pain nomenclature to collect reliable incidence and prevalence data and to inform further refinement of the construct.
突破性疼痛常见于危及生命的疾病和临终时。尽管经过了 30 多年的研究,但人们对突破性疼痛的定义和特征几乎没有达成共识。本研究旨在更新和扩展 Haugen 及其同事在 2010 年进行的系统性综述,以确定 (1) 突破性疼痛的所有定义和 (2) 患者、护理人员、临床医生和专家对突破性疼痛的所有描述和分类。该快速系统性综述遵循了 Cochrane 快速综述方法小组的指导方针。研究方案发布在 PROSPERO (CRD42019155583)上。我们在 CINAHL、MEDLINE、PsycINFO 和 Web of Science 上对突破性疼痛术语进行了检索,检索时间为各数据库的开始日期至 2022 年 8 月 26 日。我们确定了 65 项研究,其中包括来自患者(30 人)、临床医生(6 人)和专家(29 人)的有关突破性疼痛定义、描述或分类的数据,但没有一项研究包含来自护理人员的数据。大多数专家建议,突破性疼痛是指在轻度-中度背景疼痛得到充分控制的情况下,患者突然出现的剧烈、短暂的疼痛。然而,对突破性疼痛的定义各不相同,也没有达成共识。各项研究的疼痛特征大致相似,但时间因素差异很大。专家们将突破性疼痛分为痛觉型、神经病理性、内脏型、躯体型或混合型。突破性疼痛患者通常会出现抑郁、焦虑和对日常生活的干扰。尽管人们一直在努力,但仍未就突破性疼痛的定义达成共识。为了收集可靠的发病率和流行率数据,并为进一步完善这一概念提供信息,需要就突破性疼痛的命名达成妥协。
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引用次数: 0
Development and impact of a tailored eHealth resource on fibromyalgia patient’s self-management and self-efficacy: A mixed methods approach 开发量身定制的电子健康资源及其对纤维肌痛患者自我管理和自我效能的影响:混合方法
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-19 DOI: 10.1177/20494637231221647
Joanne O’Brien-Kelly, David Moore, Ian O’Leary, T. O’Connor, Zena Moore, D. Patton, L. Nugent
To develop an eHealth resource to support fibromyalgia patients and explore it for usability and impact on their self-management and self-efficacy. Fibromyalgia is a complex, non-progressive chronic condition characterised by a bewildering array of symptoms for patients to self-manage. International guidelines recommend patients receive illness-specific information once diagnosed to promote self-management and improve health-related quality of life. A 3-phase mixed methods exploratory sequential design. Qualitative interviews explored the information and self-management needs of fibromyalgia patients attending a large tertiary hospital in Dublin. Identified themes together with an extensive review of the literature of interventions proven to be impactful by patients with fibromyalgia were utilised in the design and development of the eHealth resource. The resource was tested for usability and impact using pre and post-intervention outcomes measures. Patient interviews highlighted a lack of easy accessible evidenced information to support self-management implicating the urgent need for a practical solution through development of a tailored eHealth resource. Six themes emerged for inclusion; illness knowledge, primary symptoms, treatment options, self-management strategies, practical support and reliable resources. Forty-five patients who tested the site for usability and impact demonstrated a statistically significant improvement in self-efficacy after 4 weeks access with a medium positive effect size. Patients with the most severe fibromyalgia impact scores pre-intervention demonstrated the most improvement after 4 weeks. Patients gave the resource a System Usability Score A rating, highly recommending it for fellow patients diagnosed with fibromyalgia. The study demonstrated how the development of a novel eHealth resource positively impacted fibromyalgia patients’ self-efficacy to cope with this debilitating condition. This study suggests that access to eHealth can positively impact patients self-efficacy, has the potential to be a template for eHealth development in other chronic conditions, supporting advanced nurse practitioners working in chronic disease management.
开发一种支持纤维肌痛患者的电子保健资源,并探索其可用性及其对患者自我管理和自我效能的影响。纤维肌痛是一种复杂的非进行性慢性疾病,其特点是患者需要自我管理的症状令人困惑。国际指南建议患者在确诊后接受针对具体疾病的信息,以促进自我管理并改善与健康相关的生活质量。采用三阶段混合方法探索性顺序设计。定性访谈探讨了在都柏林一家大型三甲医院就诊的纤维肌痛患者对信息和自我管理的需求。在设计和开发电子健康资源的过程中,利用了所确定的主题以及对纤维肌痛患者证明有效的干预措施文献的广泛回顾。利用干预前和干预后的结果测量,对该资源的可用性和影响进行了测试。对患者的访谈显示,他们缺乏易于获取的有据可查的信息来支持自我管理,这意味着迫切需要通过开发量身定制的电子健康资源来找到切实可行的解决方案。该网站包含六个主题:疾病知识、主要症状、治疗方案、自我管理策略、实际支持和可靠资源。45 名患者对网站的可用性和影响进行了测试,结果表明,在使用网站 4 周后,患者的自我效能感有了显著提高,且效果中等。干预前纤维肌痛影响评分最严重的患者在 4 周后的改善幅度最大。患者对该资源的系统可用性评分为 A 级,并强烈推荐给其他被诊断为纤维肌痛的患者。这项研究表明,开发新型电子健康资源如何对纤维肌痛患者应对这种衰弱病症的自我效能产生积极影响。这项研究表明,获取电子健康资源可对患者的自我效能产生积极影响,并有可能成为其他慢性病电子健康资源开发的模板,为从事慢性病管理的高级执业护士提供支持。
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引用次数: 0
Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development 针对接受阿片类药物治疗的顽固性疼痛患者提出的由执业药师主导的审查的可接受性:为制定干预措施提供信息的定性研究
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-19 DOI: 10.1177/20494637231221688
Nicola Cornwall, Charlotte Woodcock, Julie Ashworth, Sarah A Harrisson, L. Dikomitis, Simon White, T. Helliwell, Eleanor Hodgson, R. Knaggs, Tamar Pincus, M. Santer, Christian D Mallen, Clare Jinks
Regular review of patients prescribed opioids for persistent non-cancer pain (PCNP) is recommended but not routinely undertaken. The PROMPPT (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams) research programme aims to develop and test a pharmacist-led pain review (PROMPPT) to reduce inappropriate opioid use for persistent pain in primary care. This study explored the acceptability of the proposed PROMPPT review to inform early intervention development. Interviews ( n = 15) and an online discussion forum ( n = 31) with patients prescribed opioids for PCNP and interviews with pharmacists ( n = 13), explored acceptability of a proposed PROMPPT review. A prototype PROMPPT review was then tested and refined through 3 iterative cycles of in-practice testing (IPT) ( n = 3 practices, n = 3 practice pharmacists, n = 13 patients). Drawing on the Theoretical Framework of Acceptability (TFA), a framework was generated (including a priori TFA constructs) allowing for deductive and inductive thematic analysis to identify aspects of prospective and experienced acceptability. Patients felt uncertain about practice pharmacists delivering the proposed PROMPPT review leading to development of content for the invitation letter for IPT (introducing the pharmacist and outlining the aim of the review). After IPT, patients felt that pharmacists were suited to the role as they were knowledgeable and qualified. Pharmacists felt that the proposed reviews would be challenging. Although challenges were experienced during delivery of PROMPPT reviews, pharmacists found that they became easier to deliver with time, practise and experience. Recommendations for optimisations after IPT included development of the training to include examples of challenging consultations. Uptake of new healthcare interventions is influenced by perceptions of acceptability. Exploring prospective and experienced acceptability at multiple time points during early intervention development, led to mini-optimisations of the prototype PROMPPT review ahead of a non-randomised feasibility study.
建议对因持续性非癌性疼痛(PCNP)而处方阿片类药物的患者进行定期复查,但这并非常规做法。PROMPPT(由基层医疗团队中的临床药剂师牵头,对长期服用阿片类药物治疗顽固性疼痛的患者进行主动临床审查)研究项目旨在开发和测试一种由药剂师牵头的疼痛审查方法(PROMPPT),以减少基层医疗中因顽固性疼痛而不适当使用阿片类药物的情况。本研究探讨了建议的 PROMPPT 审查的可接受性,以便为早期干预措施的开发提供信息。通过对开具阿片类药物治疗 PCNP 的患者进行访谈(15 人)和在线讨论论坛(31 人),以及对药剂师进行访谈(13 人),探讨了建议的 PROMPPT 审查的可接受性。然后,通过 3 个迭代周期的实践测试 (IPT),对 PROMPPT 审查原型进行了测试和改进(3 个实践,3 个实践药剂师,13 名患者)。借鉴可接受性理论框架 (TFA),建立了一个框架(包括先验的 TFA 构建),允许进行演绎和归纳专题分析,以确定预期可接受性和经验可接受性的各个方面。患者对执业药剂师提供建议的 PROMPPT 审查感到不确定,这导致了 IPT 邀请函内容的制定(介绍药剂师并概述审查目的)。在 IPT 结束后,患者认为药剂师知识渊博、资质合格,适合担任这一角色。药剂师认为建议的复查具有挑战性。尽管在实施 PROMPPT 审查过程中遇到了挑战,但药剂师发现,随着时间的推移、实践和经验的积累,这些审查变得越来越容易实施。IPT 之后的优化建议包括开展培训,以纳入具有挑战性的咨询实例。对新医疗干预措施的接受程度受可接受性观念的影响。在早期干预开发过程中,在多个时间点探索预期和经验的可接受性,有助于在非随机可行性研究之前对 PROMPPT 审查原型进行小型优化。
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引用次数: 0
Intravenous S-ketamine’s analgesic efficacy in third molar surgery. A randomized placebo-controlled double-blind clinical trial 静脉注射S-氯胺酮对第三磨牙手术的镇痛效果。随机安慰剂对照双盲临床试验
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-15 DOI: 10.1177/20494637231222327
Lars B Eriksson, Torsten Gordh, Rolf Karlsten, Riccardo LoMartire, Andreas Thor, Åke Tegelberg
In most cases, a combination of paracetamol and ibuprofen are the optimal treatment for postoperative pain in third molar surgery. If stronger analgesia is required, opioids are traditionally administered. In day-case, surgery; however, opioids should be avoided. Thus, the anaesthetic agent S-ketamine in analgesic doses might be preferred. The study was designed as a randomized placebo-controlled double-blind clinical trial. The study enrolled healthy subjects according to the American Society of Anaesthesiologists classification; I or II (ASA), aged 18 to 44 years, with a body weight between 50 and 100 kg. The patients were randomized into three groups where two doses of S-ketamine were compared (high: 0.25 mg/kg or low: 0.125 mg/kg) with placebo (saline). A primary outcome of the study was that VAS at 4 h postoperatively, showed no significant difference between the placebo and high-dose S-ketamine group or in the low-dose group. We found a significant difference between the groups for the first 24 h, with a lower VAS-score in the high-dose S-ketamine group. The time to when 50% had taken their first rescue medication was 12 min later in the high-dose ketamine group. Pre-emptive S-ketamine 0.25 mg/kg gave a global significant reduction of pain by VAS during the first 24 h postoperatively. The time from end of surgery to first rescue medication were longer in the high-dose ketamine group compared to both low-dose ketamine and placebo groups.
在大多数情况下,扑热息痛和布洛芬是治疗第三磨牙手术术后疼痛的最佳药物。如果需要更强的镇痛效果,传统上会使用阿片类药物。但在日间手术中,应避免使用阿片类药物。因此,镇痛剂量的麻醉剂 S-Ketamine 可能是首选。该研究设计为随机安慰剂对照双盲临床试验。根据美国麻醉医师协会的分类,该研究招募了年龄在 18 至 44 岁之间、体重在 50 至 100 公斤之间的 I 类或 II 类(ASA)健康受试者。患者被随机分为三组,将两种剂量的S-氯胺酮(高剂量:0.25毫克/千克或低剂量:0.125毫克/千克)与安慰剂(生理盐水)进行比较。研究的主要结果是,术后 4 小时的 VAS 显示,安慰剂组和高剂量 S-Ketamine 组以及低剂量组之间没有显著差异。我们发现,在最初的 24 小时内,各组之间存在明显差异,高剂量 S-Ketamine 组的 VAS 评分较低。在大剂量氯胺酮组中,50%的患者服用第一种抢救药物的时间要晚12分钟。术前使用0.25毫克/千克的S-氯胺酮可在术后24小时内显著降低VAS评分。与低剂量氯胺酮组和安慰剂组相比,高剂量氯胺酮组从手术结束到首次使用抢救药物的时间更长。
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引用次数: 0
The efficacy, acceptability and safety of acceptance and commitment therapy for fibromyalgia – a systematic review and meta-analysis 接受和承诺疗法治疗纤维肌痛的疗效、可接受性和安全性--系统回顾和荟萃分析
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-12 DOI: 10.1177/20494637231221451
Florence Eastwood, Emma Godfrey
Fibromyalgia (FM) is a chronic pain disorder characterised by widespread pain, fatigue and cognitive symptoms. Acceptance and commitment therapy (ACT) aims to improve psychological flexibility and has been found to be beneficial in treating chronic pain; however, there are few studies evaluating its efficacy in treating FM. This systematic review and meta-analysis evaluated the efficacy of acceptance and commitment therapy in patients with fibromyalgia. PubMed, Embase and PsychInfo databases were searched. Randomised Controlled Trials (RCTs) were eligible for inclusion if participants had FM, and the intervention was based on the ACT framework/model, and not combined with any other active therapy; any non-ACT control was accepted. A meta-analysis was performed, with the primary outcomes pain acceptance (chronic pain acceptance questionnaire, CPAQ), health-related quality of life (fibromyalgia impact questionnaire, FIQ), attrition rate and frequency of adverse events, and the secondary outcomes pain intensity, disability, depression, anxiety, and fatigue. Six RCTs, with a total of 384, mostly-female, participants were included, with ACT being delivered online, in a group setting, or one-to-one. ACT was superior to controls in improving FIQ score at post-intervention (SMD −1.05, 95% CI −2.02, −0.09) and follow-up (SMD −1.43, 95% CI −2.17, −0.69) and CPAQ post-intervention (SMD 1.05, 95% CI 0.61, 1.49) and at follow-up (SMD 0.95, 95% CI 0.40, 1.49). Attrition was below 20% in 4/6 studies and no adverse events were reported as attributable to ACT. All secondary outcomes showed large-to-moderate pooled effect estimates post-intervention, indicating improvement in anxiety, depression, pain and disability. Fatigue also improved, with a large negative effect. The results suggest ACT improved outcomes in patients with FM: there was an overall improvement in all outcomes post-intervention, with most maintained at follow-up. This review was, however, limited by the small body of evidence and differing methodologies of included studies.
纤维肌痛(FM)是一种慢性疼痛疾病,以广泛性疼痛、疲劳和认知症状为特征。接纳与承诺疗法(ACT)旨在提高心理灵活性,已被发现对治疗慢性疼痛有益;然而,很少有研究评估其对治疗纤维肌痛的疗效。本系统综述和荟萃分析评估了接受和承诺疗法对纤维肌痛患者的疗效。检索了 PubMed、Embase 和 PsychInfo 数据库。只要参与者患有纤维肌痛,干预措施基于接纳与承诺疗法的框架/模式,且未与任何其他积极疗法相结合,任何非接纳与承诺疗法的对照研究均可纳入随机对照试验(RCT)。荟萃分析的主要结果为疼痛接受度(慢性疼痛接受度问卷,CPAQ)、健康相关生活质量(纤维肌痛影响问卷,FIQ)、减员率和不良事件频率,次要结果为疼痛强度、残疾、抑郁、焦虑和疲劳。六项研究共纳入了 384 名参与者,其中大部分为女性,ACT 采用在线、小组或一对一的方式进行。在改善干预后(SMD-1.05,95% CI -2.02,-0.09)和随访(SMD-1.43,95% CI -2.17,-0.69)的FIQ得分以及干预后(SMD 1.05,95% CI 0.61,1.49)和随访(SMD 0.95,95% CI 0.40,1.49)的CPAQ得分方面,ACT优于对照组。4/6项研究的自然减员率低于20%,无不良事件报告可归因于ACT。干预后,所有次要结果都显示出大到中等的集合效应估计值,表明焦虑、抑郁、疼痛和残疾状况有所改善。疲劳感也有所改善,并产生了较大的负效应。结果表明,ACT 可改善 FM 患者的预后:干预后所有预后均有整体改善,且大部分在随访时保持不变。然而,由于纳入研究的证据较少且研究方法各不相同,该综述受到了限制。
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引用次数: 0
Taking the pain out of pain. 从痛苦中解脱出来。
IF 1.8 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI: 10.1177/20494637231208167
Catharine Montgomery, Helen M Poole, Emma Begley, Yasir Abbasi
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引用次数: 0
Management of trigeminal neuralgia: A multi-centre case study in general practice. 三叉神经痛的治疗:全科多中心病例研究
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2023-12-01 Epub Date: 2023-09-01 DOI: 10.1177/20494637231199332
Zofia J Zakrzewska, Parinaz Hosseini-Ashrafi, Ishrat Hussain, Zachary James Moulder, Jithu Subhash, Melissa Tan, Martin Ewart Johnson, Joanna M Zakrzewska

Background and aims: Patients often first present with symptoms of trigeminal neuralgia (TN) to primary care. However, there has been little research to determine whether the diagnosis and management of this condition is carried out according to current guidelines. Furthermore, there is little up-to-date information regarding the prevalence of TN in the UK. The aim is to estimate the prevalence of TN and to audit the diagnosis and management process of TN in primary care.

Methods: Between 2019 and 2020 a search was made at five UK GP practices with a total patient population of 55,842 using EMIS and SystmOne patient record systems to review patient consultations to identify patients coded with TN or facial pain (FP). These records were reviewed to ascertain the basis for diagnosis, management in primary care and referral to secondary care.

Results: 157 patients were identified; 54 coded with FP and 103 with TN. These results indicate a prevalence of 22.3 in 10,000. There was no difference in documented symptoms between the two groups. Seven patients had all ICDH3 criteria recorded, with two meeting the requirements for TN diagnosis. 58.8% of patients with TN were started on carbamazepine, the current gold standard treatment, compared with 16.7% in the FP group. 38.2% of TN patients were referred to a range of different specialities.

Conclusion: The prevalence of TN may be higher than previously thought. Key diagnostic criteria are often omitted, leading to potential misdiagnosis or delays in diagnosis. Relatively few referrals are made, though all patients should be considered for imaging.

患者通常首先以三叉神经痛(TN)症状就诊。然而,很少有研究来确定这种情况的诊断和管理是否根据目前的指导方针进行。此外,几乎没有关于TN在英国流行的最新信息。目的是估计TN的患病率,并审计初级保健中TN的诊断和管理过程。在2019年至2020年期间,研究人员使用EMIS和SystmOne患者记录系统对5家英国全科医生诊所进行了搜索,总患者人数为55,842人,以审查患者咨询,以识别编码为TN或面部疼痛(FP)的患者。对这些记录进行了审查,以确定诊断、初级保健管理和转介到二级保健的基础。确认157例患者;54个编码FP, 103个编码TN。这些结果表明患病率为22.3 / 10000。两组之间的记录症状没有差异。7例患者全部符合ICDH3标准,2例符合TN诊断要求。58.8%的TN患者开始使用卡马西平,这是目前的金标准治疗,而FP组的这一比例为16.7%。38.2%的TN患者被转诊到不同的专科。TN的流行率可能比以前认为的要高。关键的诊断标准往往被忽略,导致潜在的误诊或延误诊断。虽然所有患者都应考虑影像学检查,但转诊病例相对较少。
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British Journal of Pain
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