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The effect of pregabalin on postoperative pain after anterior cruciate ligament reconstruction: A systematic review of randomized clinical trials. 普瑞巴林对前十字韧带重建术后疼痛的影响:随机临床试验的系统回顾。
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2023-08-01 Epub Date: 2023-02-08 DOI: 10.1177/20494637231152967
Seyyed Morteza Kazemi, Emad Kouhestani, Seyyed Mehdi Hosseini

Background: Despite the enormous success of anterior cruciate ligament (ACL) reconstruction, acute neuropathic pain can develop postoperatively and is both distressing and difficult to treat once established. Pregabalin, an anticonvulsant agent that selectively affects the nociceptive process, has been used as a pain relief agent. The purpose of this systematic review of randomized controlled trials (RCTs) was to evaluate the pain control effect of pregabalin versus placebo after ACL reconstruction.

Method: A search of the literature was performed from inception to June 2022, using PubMed, Scopus, Google Scholar, Web of Science, Cochrane and EBSCO. Studies considered for inclusion were RCTs that reported relevant outcomes (postoperative pain scores, cumulative opioid consumption, adverse events) following administration of pregabalin in patients undergoing ACL reconstruction.

Result: Five placebo-controlled RCTs involving 272 participants met the inclusion criteria. 75 mg and 150 mg oral pregabalin was used in included trials. Two studies used a single dose of pregabalin one hour before anesthesia induction. Two studies used pregabalin 1 hour before anesthesia induction and 12 hours after. One study used daily pregabalin 7 days before and 7 days after surgery. Out of five papers, three papers found significantly lower pain intensity and cumulative opioid consumption in pregabalin group compared with placebo group. However, a decrease in pain scores was found in all trials. Pregabalin administration was associated with dizziness and nausea.

Conclusion: The use of pregabalin may be a valuable asset in pain management after ACL reconstruction. However, future studies with larger sample size and longer follow-up period are required.

背景:尽管前交叉韧带(ACL)重建术取得了巨大成功,但术后仍可能出现急性神经病理性疼痛,这种疼痛既令人痛苦又难以治疗。普瑞巴林是一种选择性影响痛觉过程的抗惊厥药,已被用作止痛药。本研究对随机对照试验(RCTs)进行了系统回顾,旨在评估前交叉韧带重建术后普瑞巴林与安慰剂的止痛效果:方法:使用 PubMed、Scopus、Google Scholar、Web of Science、Cochrane 和 EBSCO 对从开始到 2022 年 6 月的文献进行了检索。纳入的研究均为报道前交叉韧带重建术患者使用普瑞巴林后相关结果(术后疼痛评分、阿片类药物累积用量、不良事件)的RCT研究:结果:有五项安慰剂对照研究符合纳入标准,共有 272 人参与。纳入的试验均使用 75 毫克和 150 毫克口服普瑞巴林。两项研究在麻醉诱导前一小时使用单剂量普瑞巴林。两项研究在麻醉诱导前 1 小时和麻醉诱导后 12 小时使用普瑞巴林。一项研究在手术前 7 天和手术后 7 天每天使用普瑞巴林。在五篇论文中,有三篇论文发现普瑞巴林组的疼痛强度和阿片类药物累积用量明显低于安慰剂组。然而,所有试验均发现疼痛评分有所下降。普瑞巴林用药与头晕和恶心有关:结论:使用普瑞巴林可能是前交叉韧带重建术后疼痛治疗的宝贵资产。结论:普瑞巴林可能是前交叉韧带重建术后疼痛治疗的重要药物,但未来的研究需要更大的样本量和更长的随访时间。
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引用次数: 0
Exploring the lived experiences of debilitating period pain management in the UK. 探索英国人经期疼痛治疗的生活经历。
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2023-08-01 Epub Date: 2023-04-26 DOI: 10.1177/20494637231172674
Parmis Vafapour, Esther Murray

Background: Five to ten percent of women experience period pains that disrupt their lives yet 4 in 5 women believe that their claims for their dysmenorrhea are not taken seriously. Within the process of seeking support and understanding about their pain, they face various barriers that prevent them from finding the answers they deserve.

Methods: Semi-structured interviews were conducted with 8 women aged 20-28 to discuss their experiences with dysmenorrhea throughout their time since menarche.

Results: Using Scheper-Hughes and Lock understanding of the mindful body, this research explores women's experiences of dysmenorrhea through their physical body (relationship with the body and needing control), the social body (cultural concepts and comparisons to others) and the body politic (medicalisation, the medical team and the transvaginal ultrasound).

Conclusions: The impact of these aspects of their mindful bodies developed arguments showing how different actors had an impact on preventing them obtaining the patient-centred care they required without resistance. More must be done to honour the experience of pain women have regarding their periods, especially by healthcare professionals. There must be consistency in the way women are approached for their dysmenorrhea to prevent discrepancies of support. This must be done with clearer guidance on what is offered to women with dysmenorrhea, especially in the primary care setting.

背景:5%到10%的女性都经历过经痛,经痛扰乱了她们的生活,但每5名女性中就有4人认为她们对痛经的诉求没有得到认真对待。在寻求支持和理解痛经的过程中,她们面临各种障碍,无法找到应有的答案:方法:对 8 名 20-28 岁的女性进行了半结构式访谈,讨论她们自月经初潮以来的痛经经历:本研究利用 Scheper-Hughes 和 Lock 对正念身体的理解,通过她们的生理身体(与身体的关系和需要控制)、社会身体(文化观念和与他人的比较)和身体政治(医疗化、医疗团队和经阴道超声波)探讨了女性的痛经经历:这些方面对她们心智身体的影响形成了一些论点,表明不同的行为者是如何阻止她们获得所需的以患者为中心的护理而不产生抵触情绪的。必须做更多的工作来尊重妇女在月经期间的疼痛体验,尤其是医护人员。接触痛经妇女的方式必须保持一致,以防止支持出现偏差。必须为痛经妇女提供更明确的指导,尤其是在初级保健领域。
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引用次数: 0
Is England facing an opioid epidemic? 英国正面临阿片类药物泛滥吗?
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 DOI: 10.1177/20494637231160684
Antonia-Olivia Roberts, Georgia C Richards

The opioid crisis in the United States (US) is one of the most high-profile public health scandals of the 21st century with millions of people unknowingly becoming dependent on opioids. The United Kingdom (UK) had the world's highest rate of opioid consumption in 2019, and opiate-related drug poisoning deaths have increased by 388% since 1993 in England and Wales. This article explores the epidemiological definitions of public health emergencies and epidemics in the context of opioid use, misuse, and mortality in England, to establish whether England is facing an opioid crisis.

美国的阿片类药物危机是21世纪最引人注目的公共卫生丑闻之一,数百万人在不知不觉中依赖阿片类药物。2019年,英国是世界上阿片类药物消费量最高的国家,自1993年以来,英格兰和威尔士与阿片类药物有关的药物中毒死亡人数增加了388%。本文探讨了在英国阿片类药物使用、滥用和死亡率背景下突发公共卫生事件和流行病的流行病学定义,以确定英国是否面临阿片类药物危机。
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引用次数: 2
Reliability and minimal detectable difference of pressure pain thresholds in a pain-free population. 无痛人群压力痛阈值的可靠性和最小检测差异。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 Epub Date: 2022-12-23 DOI: 10.1177/20494637221147185
Ryan Gl Koh, Tracy M Paul, Karlo Nesovic, Daniel West, Dinesh Kumbhare, Richard D Wilson

The objective of this work was to evaluate the inter-rater and intra-rater reliability and minimal detectable difference (MDD) of pressure pain thresholds (PPTs) in pain-free participants with two examiners over two consecutive days in a cross-sectional study design. Examiners used a standardized method to measure and locate a specific testing site over tibialis anterior for PPT testing with a hand-held algometer. The mean of each examiner's three PPT measurements was used to calculate the intraclass correlation coefficient, inter-rater reliability, and intra-rater reliability. The minimal detectable difference (MDD) was calculated. Eighteen participants were recruited (11 female). The inter-rater reliability was 0.94 and 0.96 on day 1 and day 2, respectively. Intra-rater reliability for the examiners was 0.96 and 0.92 on day 1 and day 2, respectively. The MDD on day 1 was 1.24 kg/cm2 (CI: 0.76-2.03) and the MDD on day 2 was 0.88 kg/cm2 (CI: 0.54-1.43). This study demonstrates high inter- and intra-rater reliability and the MDD values for this method of pressure algometry.

这项研究的目的是在一项横断面研究设计中,评估两名检查者在连续两天内对无痛参试者进行压力痛阈值(PPT)测试的评分者之间和评分者内部的可靠性以及最小可检测到差异(MDD)。检查人员使用标准化方法测量和定位胫骨前方的特定测试部位,并使用手持式压力计进行 PPT 测试。每位考官三次 PPT 测量结果的平均值用于计算类内相关系数、考官间可靠性和考官内部可靠性。同时还计算了最小可检测差异(MDD)。共招募了 18 名参与者(11 名女性)。第 1 天和第 2 天的评分者间信度分别为 0.94 和 0.96。第 1 天和第 2 天的检查者内部信度分别为 0.96 和 0.92。第 1 天的 MDD 为 1.24 kg/cm2(CI:0.76-2.03),第 2 天的 MDD 为 0.88 kg/cm2(CI:0.54-1.43)。这项研究证明了这种压力算法在评分者之间和评分者内部的高度可靠性和 MDD 值。
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引用次数: 0
The effects of high-definition transcranial direct current stimulation on pain modulation and stress-induced hyperalgesia. 高清晰度经颅直流电刺激对疼痛调节和压力诱发的痛觉过敏的影响。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 Epub Date: 2023-01-03 DOI: 10.1177/20494637221150333
Constantino Toufexis, Molly Macgregor, Aidan Lewis, Andrew Flood

Background: The dorsolateral prefrontal cortex (DLPFC) has been implicated in the modulation of pain-related signals. Given this involvement, manipulation of the DLPFC through transcranial direct current stimulation (tDCS) may influence internal pain modulation and decrease pain sensitivity. Acute stress is also thought to affect pain, with increased pain sensitivity observed following the presentation of an acute stressor.

Methods: A total of 40 healthy adults (50% male), ranging in age from 19 to 28 years (M = 22.13, SD = 1.92), were randomly allocated to one of two stimulation conditions (active and sham). High-definition tDCS (HD-tDCS) was applied for 10 min at 2 mA, with the anode placed over the left DLPFC. Stress was induced after HD-tDCS administration using a modified version of the Trier Social Stress Test. Pain modulation and sensitivity were assessed through the conditioned pain modulation paradigm and pressure pain threshold measurements, respectively.

Results: Compared to sham stimulation, active stimulation produced a significant increase in pain modulation capacity. No significant change in pain sensitivity and stress-induced hyperalgesia was observed following active tDCS.

Conclusion: This research shows novel evidence that anodal HD-tDCS over the DLPFC significantly enhances pain modulation. However, HD-tDCS had no effect on pain sensitivity or stress-induced hyperalgesia. The observed effect on pain modulation after a single dose of HD-tDCS over the DLPFC is a novel finding that informs further research into the utility of HD-tDCS in the treatment of chronic pain by presenting the DLPFC as an alternative target site for tDCS-induced analgesia.

背景:背外侧前额叶皮层(DLPFC)与疼痛相关信号的调节有关。鉴于这种参与,通过经颅直流电刺激(tDCS)操纵 DLPFC 可能会影响内部疼痛调节并降低疼痛敏感性。急性应激也被认为会影响疼痛,在出现急性应激源后可观察到疼痛敏感性增加:共有 40 名健康成年人(50% 为男性)被随机分配到两种刺激条件(主动刺激和假刺激)中的一种,他们的年龄从 19 岁到 28 岁不等(M = 22.13,SD = 1.92)。高清晰度 tDCS(HD-tDCS)以 2 mA 的电流持续 10 分钟,阳极置于左侧 DLPFC 上。在施用 HD-tDCS 后,使用改良版的特里尔社会压力测试法诱发压力。疼痛调制和敏感性分别通过条件性疼痛调制范式和压力痛阈测量进行评估:结果:与假刺激相比,主动刺激能显著提高疼痛调节能力。结果:与假刺激相比,主动刺激对疼痛的调节能力有明显提高,但在主动 tDCS 刺激后,疼痛敏感性和应激诱导的痛觉减退没有明显变化:这项研究提供了新的证据,证明在DLPFC上的正极HD-tDCS能显著增强疼痛调节能力。然而,HD-tDCS 对疼痛敏感性或应激诱导的痛觉减退没有影响。在DLPFC单剂量HD-tDCS后观察到的对疼痛调节的影响是一项新发现,通过将DLPFC作为tDCS诱导镇痛的另一个靶点,为进一步研究HD-tDCS在治疗慢性疼痛方面的效用提供了信息。
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引用次数: 0
Delivering equitable pain care: Lessons from the Scottish Service Model for Chronic Pain. 提供公平的疼痛护理:苏格兰慢性疼痛服务模式的经验教训。
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2023-06-01 Epub Date: 2023-05-30 DOI: 10.1177/20494637231180485
Cassandra Macgregor, Christopher Seenan, David N Blane
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引用次数: 0
A systematic review of screening diagnostic tools for trigeminal neuralgia. 三叉神经痛筛查诊断工具的系统综述。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 DOI: 10.1177/20494637221146854
Thn Teshima, J M Zakrzewska, R Potter

Background and objective: Trigeminal neuralgia (TN) is a rare chronic neuropathic pain condition of sudden and severe pain, often described as an electric shock. Diagnosis is challenging for non-expert clinicians, particularly in primary care settings. We wanted to identify and assess the diagnostic accuracy of existing screening tools for TN and orofacial pain that could be used to support the diagnosis of TN in primary care.

Databases and data treatment: We searched key databases (MEDLINE, ASSIA, Embase, and Web of Knowledge and PsycINFO) supplemented by citation tracking from January 1988 to 2021. We used an adapted version of the Quality of Diagnostic Accuracy Studies (QUADAS-2) to assess the methodological quality of each study.

Results: Searches identified five studies, from the UK, USA and Canada; three validated self-report questionnaires; and two artificial neural networks. All screened for multiple orofacial pain diagnoses, including dentoalveolar pain, musculoskeletal pain (temporomandibular disorders) and neurological pain (trigeminal neuralgia, headache, atypical facial pain and postherpetic neuralgia). The overall quality assessment was low for one study.

Conclusions: Diagnosis of TN can be challenging for non-expert clinicians. Our review found few existing screening tools to diagnose TN, and none is currently suitable to be used in primary care settings. This evidence supports the need to adapt an existing tools or to create a new tool for this purpose. The development of an appropriate screening questionnaire could assist non-expert dental and medical clinicians to identify TN more effectively and empower them to manage or refer patients for treatment more effectively.

背景与目的:三叉神经痛(TN)是一种罕见的慢性神经性疼痛,通常表现为突然和剧烈的疼痛,通常被描述为电击。诊断是非专家临床医生具有挑战性,特别是在初级保健机构。我们想确定和评估现有筛查工具对TN和口面部疼痛的诊断准确性,这些工具可用于支持初级保健中TN的诊断。数据库和数据处理:我们检索了关键数据库(MEDLINE, ASSIA, Embase, Web of Knowledge和PsycINFO),并辅以1988年1月至2021年的引文跟踪。我们使用了诊断准确性研究质量(QUADAS-2)的改编版本来评估每项研究的方法学质量。结果:检索确定了来自英国、美国和加拿大的五项研究;三份有效的自我报告问卷;还有两个人工神经网络。所有患者均筛查了多种口腔面部疼痛诊断,包括牙槽痛、肌肉骨骼痛(颞下颌疾病)和神经疼痛(三叉神经痛、头痛、非典型面部疼痛和带状疱疹后神经痛)。其中一项研究的总体质量评价较低。结论:TN的诊断对非专家临床医生具有挑战性。我们的回顾发现很少有现有的筛查工具来诊断TN,目前没有一个适合在初级保健机构中使用。这一证据支持有必要为此目的调整现有工具或创建新工具。制定适当的筛查问卷可以帮助非专家牙科和医疗临床医生更有效地确定TN,并使他们能够更有效地管理或转诊患者进行治疗。
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引用次数: 1
A Comparison of Social Exclusion Towards People with Depression or Chronic Back Pain. 抑郁症和慢性背痛患者的社会排斥比较。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 DOI: 10.1177/20494637221148337
Lucy Roberts-West, Amy Gravatt, Natasha Guest, Ashley Hunt, Laraib Siddique, Danijela Serbic

Objectives: Research comparing mental and physical health stigma is scarce. The aim of this study was to compare social exclusion towards hypothetical males and females with depression or chronic back pain. Furthermore, the study investigated whether social exclusion is associated with participant's empathy and personality traits, while controlling for their sex, age and personal exposure to mental/physical chronic health conditions.

Design: This study employed a cross-sectional questionnaire design.

Methods: Participants (N = 253) completed an online vignette-based questionnaire and were randomly allocated to either a depression or chronic back pain study condition. Measures of social exclusion through respondents' willingness to interact with hypothetical individuals, empathy and the Big Five personality traits were completed.

Results: Willingness to interact scores did not significantly differ depending on the diagnosis or sex of the hypothetical person in the vignette. For depression, higher levels of conscientiousness significantly predicted less willingness to interact. Whilst being a female participant and having higher empathy significantly predicted greater willingness to interact. For chronic back pain, higher empathy significantly predicted greater willingness to interact, with no significant predictors found from the Big Five personality traits.

Conclusion: Findings indicate that females and males with depression or chronic back pain face similar levels of social exclusion, with empathy being a core variable driving social exclusion behaviours. These findings enhance our understanding of potential variables driving social exclusion, in-turn informing campaign development to reduce public stigma towards depression and chronic back pain.

目的:比较心理和身体健康病耻感的研究很少。这项研究的目的是比较假设患有抑郁症或慢性背痛的男性和女性的社会排斥。此外,本研究还调查了社会排斥是否与参与者的共情和人格特征有关,同时控制了他们的性别、年龄和个人精神/身体慢性健康状况。设计:本研究采用横断面问卷设计。方法:参与者(N = 253)完成了一份基于小视频的在线问卷,并被随机分配到抑郁症或慢性背痛研究状态。通过受访者与假设个体互动的意愿、同理心和五大人格特征来完成社会排斥的测量。结果:互动意愿得分没有显著差异取决于诊断或性别假想的人在小插图。对于抑郁症来说,较高的责任心显著预示着更少的互动意愿。而作为女性参与者,同理心越强,互动意愿越高。对于慢性背痛,更高的同理心显著预示着更大的互动意愿,而五大人格特质中没有发现显著的预测因素。结论:研究结果表明,患有抑郁症或慢性背痛的女性和男性面临相似的社会排斥水平,共情是驱动社会排斥行为的核心变量。这些发现增强了我们对导致社会排斥的潜在变量的理解,进而为运动发展提供信息,以减少公众对抑郁症和慢性背痛的耻辱感。
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引用次数: 0
An updated audit of the patient selection process for pain management programmes in a speciality care service before and during the COVID-19 pandemic. 在COVID-19大流行之前和期间对专科护理服务中疼痛管理规划的患者选择过程进行的最新审计。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 DOI: 10.1177/20494637221147200
Valentina Buscemi, Joe Chicken, Tim Mahy, Lucie Knight, Whitney Scott

Background: The provision of pain management programmes (PMPs) changed substantially in response to the COVID-19 pandemic with virtual delivery implemented in many services. Little is known about patient selection processes for virtual PMPs and how this might differ from in-person programmes. The aim of this audit was to document the patient selection process for PMPs at a speciality pain service prior to and during the pandemic.

Methods: This retrospective audit used data from consecutive patients attending a multidisciplinary assessment to determine the suitability of a PMP. Anonymized data were extracted from assessment letters and hospital records in the months prior to the pandemic (n =168) and during the start of the pandemic once the service began delivering virtual PMPs (n =171).

Results: For the standard pain management pathway, most patients were offered a PMP option within the service before and during the pandemic, although a greater proportion of patients were offered treatment during the pandemic. For the neuromodulation pathway, most patients were offered a pre-neuromodulation PMP option, and this was similar before and during the pandemic. Psychosocial complexities and unwillingness to engage in a pain management approach that does not principally focus on pain reduction were the most common reasons that patients were not offered a programme.

Discussion: This audit points to a pattern of more inclusive assessment outcomes within our service over time and particularly during the pandemic. Offering a range of in-person and virtual PMPs can meet a wider range of patient need. Research is needed to understand how to best assess and match patients with the breadth of treatment delivery formats now available.

背景:为应对COVID-19大流行,疼痛管理规划(pmp)的提供发生了重大变化,许多服务实施了虚拟交付。人们对虚拟pmp的患者选择过程知之甚少,也不知道这与面对面的项目有何不同。这次审计的目的是记录在大流行之前和期间在专业疼痛服务中选择pmp患者的过程。方法:回顾性审计使用了参加多学科评估的连续患者的数据,以确定PMP的适用性。从大流行前几个月(n =168)和大流行开始期间(n =171)的评估信和医院记录中提取匿名数据。结果:对于标准疼痛管理途径,在大流行之前和期间,大多数患者在服务中提供了PMP选项,尽管在大流行期间提供了更大比例的患者治疗。对于神经调节途径,大多数患者接受了神经调节前的PMP选择,这在大流行之前和期间是相似的。心理社会复杂性和不愿意参与疼痛管理方法,而不是主要侧重于减轻疼痛是患者没有提供方案的最常见原因。讨论:这次审计表明,随着时间的推移,特别是在大流行期间,我们的服务部门的评估结果更具包容性。提供一系列面对面和虚拟的pmp可以满足更广泛的患者需求。需要进行研究,以了解如何最好地评估和匹配患者与目前可用的治疗提供形式的广度。
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引用次数: 3
'Power to the People, to the people': Training for social prescribers improves support of persistent pain. “权力给人民,给人民”:对社会开处方者的培训改善了对持续性疼痛的支持。
IF 1.8 Q2 Medicine Pub Date : 2023-06-01 DOI: 10.1177/20494637231152979
Alex Corline, Frances Cole, Louise Trewern, Chris Penlington

Introduction: Supported self-management is an important aspect of managing pain, however widely held beliefs about the biomedical nature of pain and limited time availability can make it a tricky concept to introduce to patients. Social prescribers are in an ideal position to support self-management of pain if appropriate training is available to support them. This study aimed to evaluate training for social prescribers and to explore their opinions and experiences about providing self-management support.

Methods: This was a mixed methods study. Repeated measures t-tests were used to compare the reported confidence of attendees in supporting different facets of self-management before and after the training. Thematic analysis of interviews was used to develop a deeper understanding of how participants related the training to their work with patients.

Results: Average confidence improved in all aspects of supporting self-management, and particularly with regard to supporting understanding pain, acceptance, pacing, setting goals, sleep and managing setbacks. Challenges were identified around explaining pain in an accurate and accessible way in order to provide a meaningful rationale for self-management.

Conclusion: Training for social prescribers in self-management support is feasible and leads to improvements in self-reported confidence. Further research is needed to determine the impact on patients and over a longer period of time.

导言:支持性自我管理是疼痛管理的一个重要方面,然而,人们普遍认为疼痛的生物医学性质和有限的时间可用性使其成为一个棘手的概念,以介绍给患者。如果有适当的培训,社会开处方者处于支持自我管理疼痛的理想地位。本研究旨在评估社会处方医师的培训,并探讨他们对自我管理支持的意见和经验。方法:采用混合方法进行研究。使用重复测量t检验来比较培训前后参与者在支持自我管理不同方面的报告信心。访谈的专题分析被用来更深入地了解参与者如何将培训与他们与患者的工作联系起来。结果:在支持自我管理的各个方面的平均信心都有所提高,特别是在支持理解痛苦、接受、节奏、设定目标、睡眠和管理挫折方面。为了为自我管理提供有意义的理论基础,我们确定了以准确和可访问的方式解释疼痛的挑战。结论:对社会开处方者进行自我管理支持培训是可行的,可提高自述信心。需要进一步的研究来确定对患者和更长时间的影响。
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引用次数: 3
期刊
British Journal of Pain
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