Lancet Microbe最新文献

{"title":"Thank you to The Lancet Microbe statistical and peer reviewers in 2025","authors":"The Lancet Microbe (Editors)","doi":"10.1016/j.lanmic.2026.101350","DOIUrl":"10.1016/j.lanmic.2026.101350","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101350"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USA300 North American epidemic meticillin-resistant Staphylococcus aureus in South America: new pathogenicity island","authors":"Gregory Melocco , Karine Dantas , Herrison Fontana , Caroline L Martini , Elder Sano , Felipe Vasquez-Ponce , Johana Becerra , Bruna Fuga , Fernanda Esposito , Mateus R Ribas , Alessandro C O Silveira , Nilton Lincopan","doi":"10.1016/j.lanmic.2025.101276","DOIUrl":"10.1016/j.lanmic.2025.101276","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101276"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance in bacterial meningitis caused by Streptococcus pneumoniae, Neisseria meningitidis, or Haemophilus influenzae (2010–24): a systematic review and meta-analysis","authors":"Gilbert Lazarus MD , Benjamin Caddey MSc , Anna Dean DVM MIPH PhD , Florentina Febrina BSc MD , Vincent Kharisma Wangsaputra MD MRes , Shafira Permata Radiani SKM , Yindi Xiong MSc , Prof John M Conly MD FRCPC , Prof Herman W Barkema DVM PhD FCAHS , Lorenzo Pezzoli DVM MSc PhD , Esther van Kleef PhD , Olga Tosas Auguet DVM PhD , Prof Paul Turner MBBS PhD , Kavita U Kothari MSc , Silvia Bertagnolio MD PhD , Diego B Nobrega DVM MSc PhD , Raph L Hamers MD PhD","doi":"10.1016/j.lanmic.2025.101238","DOIUrl":"10.1016/j.lanmic.2025.101238","url":null,"abstract":"<div><h3>Background</h3><div>There are fragmented data on the patterns of antimicrobial resistance in the main bacterial pathogens causing meningitis, especially in low-income and middle-income countries (LMICs) where the disease burden is highest. This review aimed to estimate meningitis-specific prevalence of antimicrobial resistance and time trends, globally and for each of the WHO regions, for the main antimicrobials used to treat or prevent meningitis.</div></div><div><h3>Methods</h3><div>In this systematic review and meta-analysis, we systematically searched Embase, Global Health Database, and MEDLINE for original, peer-reviewed articles in any language, published between Jan 1, 2010, and May 16, 2024, describing people diagnosed with a microbiologically confirmed meningitis caused by <em>Streptococcus pneumoniae</em>, <em>Neisseria meningitidis</em>, or <em>Haemophilus influenzae</em>, with antimicrobial susceptibility testing results. We excluded reports that did not describe specimen type, sampling period, geographical setting, denominators, or proportions for single-agent and class resistance. We used multilevel random-effect meta-analysis on summary data to estimate the prevalence and time trends of antimicrobial resistance for relevant pathogen–antimicrobial combinations in each WHO region and globally. To assess article quality, we adopted the Microbiology Investigation Criteria for Reporting Objectively (MICRO) checklist. This review was registered with PROSPERO (CRD42019155379).</div></div><div><h3>Findings</h3><div>The search yielded 1503 studies. After the removal of 606 duplicates, 665 from title and abstract screening, and 140 from full-text screening, 92 reports were eligible for inclusion. A further four were removed due to duplicate datasets. We included 88 reports and extracted data on 16 441 clinical isolates from 37 countries across all WHO regions, mostly LMICs. For <em>S pneumoniae</em> (81 reports, 13 295 isolates), prevalence of antimicrobial resistance was highest in the Western Pacific and Eastern Mediterranean regions, ranging across WHO regions from 14·7% (95% CI 4·5–29·5) to 58·0% (34·9–79·5) for benzylpenicillin (27·4% [19·0–36·6] globally), and from 3·8% (0·0–13·7) to 20·6% (2·2–50·8) for third-generation cephalosporins (3GCs; 8·8% [4·3–14·6] globally). Benzylpenicillin resistance in <em>S pneumoniae</em> meningitis increased over time in LMICs, whereas benzylpenicillin and 3GC resistance decreased over time in high-income countries. For <em>N meningitidis</em> (11 reports, 3001 isolates), prevalence of antimicrobial resistance was highest in the African region, ranging across WHO regions from 9·4% (7·2–11·8) to 44·9% (0·0–100·0) for benzylpenicillin (24·7% [5·3–52·3] globally, increasing over time); from 0·0% (0·0–0·1) to 17·0% (0·0–100·0) for 3GCs (4·6% [0·0–19·4] globally); and from 0·0% (0·0–0·2) to 17·1% (0·0–100·0) for ciprofloxacin (3·7% [0·0-25·9] globally). Among <em>H influenzae</em> isolates (five re","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101238"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global biological sample collections from tuberculosis studies: a scoping review","authors":"Cara Adolph PhD ,&nbsp;Simon C Mendelsohn PhD ,&nbsp;Laura E Via PhD ,&nbsp;Leonardo Martinez PhD ,&nbsp;Cecilia S Lindestam Arlehamn PhD ,&nbsp;Prof David M Lewinsohn PhD ,&nbsp;Jordi B Torrelles PhD ,&nbsp;Prof Philip C Hill MD","doi":"10.1016/j.lanmic.2025.101287","DOIUrl":"10.1016/j.lanmic.2025.101287","url":null,"abstract":"<div><div>Progress in tuberculosis vaccine development is hindered by the incomplete understanding of protective immunity and other disease mechanisms. An interconnected network of sample biorepositories from tuberculosis studies could help to address these gaps. To assess the feasibility of such a resource, we conducted a scoping review of tuberculosis observational studies and vaccine clinical trials. The included studies collected at least one biological sample from tuberculosis cases, contacts, or controls and had more than 100 participants. We contacted the corresponding authors of these studies to determine the sample availability and interest in interconnected biorepositories. For the period 2014–24, we identified 104 observational studies and 18 vaccine trials that collected biological samples from 35 075 tuberculosis cases, 39 450 contacts or controls, and 45 628 trial participants across 43 countries. The commonly collected samples were blood, human genomic DNA, RNA, and sputum. Interest among the contacted investigators was high. Interconnected sample biorepositories could facilitate large-scale investigations and accelerate progress towards tuberculosis vaccine development.</div></div>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101287"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemic potential of SFTSV: increasing evidence for non-vector-borne transmission","authors":"Wen Zheng ,&nbsp;Hong Zhou ,&nbsp;Michael J Carr ,&nbsp;Weifeng Shi","doi":"10.1016/j.lanmic.2025.101271","DOIUrl":"10.1016/j.lanmic.2025.101271","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101271"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health security at genomic artificial intelligence–antimicrobial resistance frontiers in low-income countries","authors":"Dickson Aruhomukama ,&nbsp;Dathan M Byonanebye ,&nbsp;Francis Kakooza","doi":"10.1016/j.lanmic.2025.101282","DOIUrl":"10.1016/j.lanmic.2025.101282","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101282"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Africa launches plan to eliminate cholera by 2030","authors":"Munyaradzi Makoni","doi":"10.1016/j.lanmic.2025.101284","DOIUrl":"10.1016/j.lanmic.2025.101284","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101284"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maldives achieves triple elimination of mother-to-child disease transmission","authors":"Priya Venkatesan","doi":"10.1016/j.lanmic.2025.101322","DOIUrl":"10.1016/j.lanmic.2025.101322","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101322"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis","authors":"Marjorie J Gibbon PhD ,&nbsp;Natacha Couto PhD ,&nbsp;Keira Cozens MSc ,&nbsp;Samia Habib PhD ,&nbsp;Lauren Cowley PhD ,&nbsp;Prof David M Aanensen PhD ,&nbsp;Prof Jukka Corander PhD ,&nbsp;Harry A Thorpe PhD ,&nbsp;Marit A K Hetland MSc ,&nbsp;Davide Sassera PhD ,&nbsp;Cristina Merla PhD ,&nbsp;Marta Corbella MSc ,&nbsp;Carolina Ferrari MSc ,&nbsp;Prof Katy M E Turner PhD ,&nbsp;Kwanrawee Sirikanchana PhD ,&nbsp;Punyawee Dulyayangkul PhD ,&nbsp;Nisanart Charoenlap PhD ,&nbsp;Prof Visanu Thamlikitkul MD ,&nbsp;Prof Matthew B Avison PhD ,&nbsp;Prof Edward J Feil PhD","doi":"10.1016/j.lanmic.2025.101236","DOIUrl":"10.1016/j.lanmic.2025.101236","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Klebsiella pneumoniae&lt;/em&gt; is an important pathogen of humans and animals. In the past five years, increasing reports of convergent strains that carry both virulence factors and antimicrobial resistance genes (ARGs) have raised serious public health concerns. The aim of this study is to describe the global diversity of plasmids carrying &lt;em&gt;iuc3&lt;/em&gt; (a key virulence factor in &lt;em&gt;K pneumoniae&lt;/em&gt; associated with pigs and clinical isolates) from diverse settings, and their role in the emergence of convergent strains through hybridisation with plasmids carrying ARGs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This population genomic analysis study was designed to describe both the global and local diversity of &lt;em&gt;iuc3&lt;/em&gt;-carrying plasmids from diverse sources, and the co-occurrence of &lt;em&gt;iuc3&lt;/em&gt; with ARGs. We used all 4148 &lt;em&gt;Klebsiella&lt;/em&gt; spp isolates from two large One-Health studies (SpARK, Italy, and OH-DART, Thailand), including 191 &lt;em&gt;Klebsiella&lt;/em&gt; isolates from pigs, 635 from clinical isolates, 1040 from hospital and community carriage, and 2282 from other sources. Short-read sequencing of &lt;em&gt;Klebsiella&lt;/em&gt; isolates was performed as part of the SpARK study. We sequenced &lt;em&gt;Klebsiella&lt;/em&gt; isolates from the OH-DART (MicrobesNG, Birmingham, UK; HiSeq and NovaSeq, Illumina San Diego, CA, USA; GridION, Oxford Nanopore Technologies, Oxford, UK) and SpARK (MinION or GridION, Oxford Nanopore Technologies, Oxford, UK) studies. We also retrieved plasmid sequences carrying &lt;em&gt;iuc3&lt;/em&gt; from the National Centre for Biotechnology Information (NCBI). To ascertain the degree of diversity, evolutionary dynamics, and structuring across ecological and geographical axes, we detected ARGs and virulence loci, analysed clustering patterns and generated approximate maximum-likelihood phylogenetic trees.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;We identified 48 &lt;em&gt;K pneumoniae&lt;/em&gt; isolates with &lt;em&gt;iuc3&lt;/em&gt; in the SpARK data and 79 in the OH-DART data. Three (2·4%) of these 127 isolates were from clinical sources, 73 (57·5%) were from pig or pork meat. &lt;em&gt;iuc3&lt;/em&gt; isolates corresponded to multiple (n=47) host sequence types (STs), with ST35, ST45, ST881, ST25, and ST967 harbouring &lt;em&gt;iuc3&lt;/em&gt; in both datasets. We generated hybrid assemblies for 44 (SpARK) and 36 (OH-DART) isolates, plus a single &lt;em&gt;iuc3&lt;/em&gt; isolate from Germany. 53 (65·4%) of these isolates were from pigs, three (3·7%) from clinical sources, and 25 (30·9%) from other sources. There were an additional 48 &lt;em&gt;iuc3&lt;/em&gt; positive isolates from our collections for which only short read data was available. A single &lt;em&gt;iuc3&lt;/em&gt;-positive &lt;em&gt;Klebsiella oxytoca&lt;/em&gt; isolate from a pig farm was detected in the SpARK data, which was also sequenced. We identified 330 &lt;em&gt;iuc3&lt;/em&gt;-positive isolates and 58 &lt;em&gt;iuc3&lt;/em&gt;-carrying plasmid assemblies from NCBI, of which 83 (21·4%) were from clinical sources, 120 from pigs (30·9%), and 185 (47·7%) from other sou","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101236"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular epidemiology of clinical carbapenem-resistant Citrobacter spp in China (2016–24)","authors":"Ying Fu ,&nbsp;Yanfei Wang ,&nbsp;Bingyan Yao ,&nbsp;Hua Zhou ,&nbsp;Jintao He","doi":"10.1016/j.lanmic.2025.101250","DOIUrl":"10.1016/j.lanmic.2025.101250","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":"7 2","pages":"Article 101250"},"PeriodicalIF":20.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}