Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2023.04.005
Brenda J. Caro-Cocotle , Lucía Peñalosa , María-Fernanda Mejía-Ávila , Angélica Vargas-Guerrero , Manuel Martínez-Lavín
The sensitivity of plastic artists to human suffering has been expressed in different ways. This article recounts the circumstances that led the Spanish-Mexican surrealist painter, Remedios Varo, to depict in an original way the 2 cardinal manifestations of fibromyalgia; widespread pain and insomnia.
{"title":"Las manifestaciones primordiales de la fibromialgia, dolor generalizado e insomnio, en la pintura de Remedios Varo","authors":"Brenda J. Caro-Cocotle , Lucía Peñalosa , María-Fernanda Mejía-Ávila , Angélica Vargas-Guerrero , Manuel Martínez-Lavín","doi":"10.1016/j.reuma.2023.04.005","DOIUrl":"10.1016/j.reuma.2023.04.005","url":null,"abstract":"<div><p>The sensitivity of plastic artists to human suffering has been expressed in different ways. This article recounts the circumstances that led the Spanish-Mexican surrealist painter, Remedios Varo, to depict in an original way the 2 cardinal manifestations of fibromyalgia; widespread pain and insomnia.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45739131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2023.01.003
Sara Alonso , Isla Morante , Ignacio Braña , Rubén Queiro
Background and aims
Sleep problems are common in spondyloarthritis (SpA), but the factors associated with them are only partially known. In this study, responses to item #16 from the Assessment of SpondyloArthritis international Society-Health Index (ASAS HI) that explores the sleep category according to the International Classification of Functioning, Disability and Health (ICF) were compared between psoriatic arthritis (PsA) and axial SpA (axSpA).
Methods
Post hoc analysis of a multicentre cross-sectional study included a total of 201 consecutive patients. The prevalence, correlations, and disease factors associated with a positive response to item #16 were analyzed in both SpA populations.
Results
Forty-eight/111 (43.2%) patients with axSpA and 42/90 (46.7%) with PsA reported sleep problems. There was a moderate–high correlation between item #16 and the ASAS HI sum score in both populations (r ≥ .59). In axSpA, poor sleep was associated with disease activity (OR 8.45, p < .001), biological therapy use (OR .24, p < .05) and CRP levels (OR .16, p < .05). In PsA, disturbed sleep was independently associated with disease activity showing a dose-response effect (OR 1.16, p < .001). Taking both populations together, disease severity (OR 6.33, p < .001) and axSpA (OR .50, p < .05) were independently associated with a positive response to item #16. Correlations between the different components of the ASAS HI and item #16 were markedly different in both populations.
Conclusions
A positive response to item #16 was common in both SpA phenotypes. However, the link between inflammatory burden and disturbed sleep was higher in axSpA than in PsA.
背景和目的睡眠问题在脊椎关节炎(SpA)中很常见,但与之相关的因素仅部分为人所知。在这项研究中,对根据国际功能、残疾和健康分类(ICF)探讨睡眠类别的国际社会健康指数(ASAS HI)评估中的第16项的反应在银屑病关节炎(PsA)和轴向SpA (axSpA)之间进行了比较。方法对一项包括201例连续患者的多中心横断面研究进行事后分析。在两个SpA人群中分析了与项目#16阳性反应相关的患病率、相关性和疾病因素。结果axSpA患者中48 /111(43.2%)和PsA患者中42/90(46.7%)报告睡眠问题。在两个人群中,第16项与ASAS HI总分之间存在中-高相关性(r≥0.59)。在axSpA中,睡眠不足与疾病活动相关(OR 8.45, p <.001),生物疗法使用(OR .24, p <0.05)和CRP水平(OR .16, p <. 05)。在PsA中,睡眠障碍与疾病活动独立相关,显示出剂量-反应效应(OR 1.16, p <措施)。将这两个人群加在一起,疾病严重程度(OR 6.33, p <.001)和axSpA (OR .50, p <.05)与对第16项的积极反应独立相关。在两个人群中,ASAS HI和项目#16的不同成分之间的相关性显着不同。结论项目16的阳性反应在两种SpA表型中都很常见。然而,与PsA相比,axSpA中炎症负担和睡眠紊乱之间的联系更高。
{"title":"Altered sleep in axial spondyloarthritis and psoriatic arthritis: Post hoc comparative study based on a sleep-specific question from the ASAS health index","authors":"Sara Alonso , Isla Morante , Ignacio Braña , Rubén Queiro","doi":"10.1016/j.reuma.2023.01.003","DOIUrl":"https://doi.org/10.1016/j.reuma.2023.01.003","url":null,"abstract":"<div><h3>Background and aims</h3><p>Sleep problems are common in spondyloarthritis (SpA), but the factors associated with them are only partially known. In this study, responses to item #16 from the Assessment of SpondyloArthritis international Society-Health Index (ASAS HI) that explores the sleep category according to the International Classification of Functioning, Disability and Health (ICF) were compared between psoriatic arthritis (PsA) and axial SpA (axSpA).</p></div><div><h3>Methods</h3><p><em>Post hoc</em> analysis of a multicentre cross-sectional study included a total of 201 consecutive patients. The prevalence, correlations, and disease factors associated with a positive response to item #16 were analyzed in both SpA populations.</p></div><div><h3>Results</h3><p>Forty-eight/111 (43.2%) patients with axSpA and 42/90 (46.7%) with PsA reported sleep problems. There was a moderate–high correlation between item #16 and the ASAS HI sum score in both populations (<em>r</em> <!-->≥<!--> <!-->.59). In axSpA, poor sleep was associated with disease activity (OR 8.45, <em>p</em> <!--><<!--> <!-->.001), biological therapy use (OR .24, <em>p</em> <!--><<!--> <!-->.05) and CRP levels (OR .16, <em>p</em> <!--><<!--> <!-->.05). In PsA, disturbed sleep was independently associated with disease activity showing a dose-response effect (OR 1.16, <em>p</em> <!--><<!--> <!-->.001). Taking both populations together, disease severity (OR 6.33, <em>p</em> <!--><<!--> <!-->.001) and axSpA (OR .50, <em>p</em> <!--><<!--> <!-->.05) were independently associated with a positive response to item #16. Correlations between the different components of the ASAS HI and item #16 were markedly different in both populations.</p></div><div><h3>Conclusions</h3><p>A positive response to item #16 was common in both SpA phenotypes. However, the link between inflammatory burden and disturbed sleep was higher in axSpA than in PsA.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2023.01.001
Leire Cruz-Gambero , Alejandra Lucía Tuljak , Santiago Garcia Orza , Jorge H. Villafañe , Raquel Cantero-Téllez
Background and objectives
Osteoarthritis at the base of the thumb (CMC-1 OA) is a pathology that mainly affects postmenopausal women. The main symptoms including pain, decreased hand-thumb strength and fine motor capacity. Although a proprioceptive deficit has already been demonstrated in people with CMC-1 OA, there is insufficient evidence regarding the effects of proprioceptive training. The main objective of this study is to determine the effectiveness of proprioceptive training in functional recovery.
Materials and methods
A total of 57 patients were included in the study, 29 in the control group and 28 in the experimental group. Both groups underwent the same basic intervention programme, but the experimental group included a proprioceptive training protocol. Variables of the study were pain (VAS), perception of occupational performance (COMP), sense position (SP) and force sensation (FS).
Results
Statistically significant improvement was observed in the experimental group in pain (p < .05) and occupational performance (p < .001) after 3 months of treatment. No statistical differences were found in sense position (SP) or sensation of force (FS).
Discussion and conclusions
The results concord with previous studies focussing on proprioception training. The incorporation of a proprioceptive exercise protocol reduces pain and significantly improves occupational performance.
{"title":"Efectividad del entrenamiento propioceptivo en la recuperación funcional de la artrosis en la base del pulgar. Ensayo clínico multicéntrico con aleatorización simple no cegado","authors":"Leire Cruz-Gambero , Alejandra Lucía Tuljak , Santiago Garcia Orza , Jorge H. Villafañe , Raquel Cantero-Téllez","doi":"10.1016/j.reuma.2023.01.001","DOIUrl":"10.1016/j.reuma.2023.01.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Osteoarthritis at the base of the thumb (CMC-1 OA) is a pathology that mainly affects postmenopausal women. The main symptoms including pain, decreased hand-thumb strength and fine motor capacity. Although a proprioceptive deficit has already been demonstrated in people with CMC-1 OA, there is insufficient evidence regarding the effects of proprioceptive training. The main objective of this study is to determine the effectiveness of proprioceptive training in functional recovery.</p></div><div><h3>Materials and methods</h3><p>A total of 57 patients were included in the study, 29 in the control group and 28 in the experimental group. Both groups underwent the same basic intervention programme, but the experimental group included a proprioceptive training protocol. Variables of the study were pain (VAS), perception of occupational performance (COMP), sense position (SP) and force sensation (FS).</p></div><div><h3>Results</h3><p>Statistically significant improvement was observed in the experimental group in pain (p<!--> <!--><<!--> <!-->.05) and occupational performance (p<!--> <!--><<!--> <!-->.001) after 3 months of treatment. No statistical differences were found in sense position (SP) or sensation of force (FS).</p></div><div><h3>Discussion and conclusions</h3><p>The results concord with previous studies focussing on proprioception training. The incorporation of a proprioceptive exercise protocol reduces pain and significantly improves occupational performance.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48929701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2023.04.002
Luis Del Carpio-Orantes, Brenda López-Benjume, Sergio García-Méndez, Jesús Salvador Sánchez-Díaz, Ada Lili Rosas-Lozano, Saray Guadalupe Mejía-Ramos, Andrés Aguilar-Silva, Sara Nohemí Hernández-Hernández
Catastrophic antiphospholipid syndrome (CAPS) is a rare entity, approximately 600 cases have been reported around the world, and the prevalence in Mexico is unknown.
Objective
To determine the estimated prevalence of CAPS in Mexico.
Material and methods
A literature search of isolated clinical cases or case series was conducted in diverse search engines, using the terms: «catastrophic antiphospholipid syndrome» and «Mexico» in May 2022.
Results
We found a series of retrospective cases in autopsies that included 12 cases, two reports that included 2 cases each, and reports of 11 isolated clinical cases; these publications were generated between 2003 and 2020. In total, we collected data on 27 cases of CAPS, of which 16 correspond to primary antiphospholipid syndrome, 10 are associated with systemic lupus erythematosus, and 1 case corresponds to systemic sclerosis. The estimated prevalence rate in the Mexican population in 2022 is 2 cases per 10,000,000 inhabitants. The estimated mortality was 68% in this case series.
Conclusion
Cases of catastrophic antiphospholipid syndrome in Mexico are underreported; identifying them will help improve current diagnostic and therapeutic strategies used in the country, encouraging the implementation of triple therapy and, in refractory cases, the use of eculizumab, to reduce current mortality.
{"title":"Síndrome antifosfolípidos catastrófico en México. Revisión de la bibliografía","authors":"Luis Del Carpio-Orantes, Brenda López-Benjume, Sergio García-Méndez, Jesús Salvador Sánchez-Díaz, Ada Lili Rosas-Lozano, Saray Guadalupe Mejía-Ramos, Andrés Aguilar-Silva, Sara Nohemí Hernández-Hernández","doi":"10.1016/j.reuma.2023.04.002","DOIUrl":"10.1016/j.reuma.2023.04.002","url":null,"abstract":"<div><p>Catastrophic antiphospholipid syndrome (CAPS) is a rare entity, approximately 600 cases have been reported around the world, and the prevalence in Mexico is unknown.</p></div><div><h3>Objective</h3><p>To determine the estimated prevalence of CAPS in Mexico.</p></div><div><h3>Material and methods</h3><p>A literature search of isolated clinical cases or case series was conducted in diverse search engines, using the terms: «catastrophic antiphospholipid syndrome» and «Mexico» in May 2022.</p></div><div><h3>Results</h3><p>We found a series of retrospective cases in autopsies that included 12 cases, two reports that included 2 cases each, and reports of 11 isolated clinical cases; these publications were generated between 2003 and 2020. In total, we collected data on 27 cases of CAPS, of which 16 correspond to primary antiphospholipid syndrome, 10 are associated with systemic lupus erythematosus, and 1 case corresponds to systemic sclerosis. The estimated prevalence rate in the Mexican population in 2022 is 2 cases per 10,000,000 inhabitants. The estimated mortality was 68% in this case series.</p></div><div><h3>Conclusion</h3><p>Cases of catastrophic antiphospholipid syndrome in Mexico are underreported; identifying them will help improve current diagnostic and therapeutic strategies used in the country, encouraging the implementation of triple therapy and, in refractory cases, the use of eculizumab, to reduce current mortality.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43838721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2023.02.009
Natalia Gabriela Sanchez , Natalia Rebollo Domínguez , Eduwiges Martínez Luna , Pablo Villaseñor Ovies
Keloidal or nodular scleroderma (NS) is a variant of localized scleroderma (LS) frequently seen in patients with limited or diffuse systemic sclerosis (SSc). It presents as raised, firm plaques or nodules with extensive dermal fibrosis and hyalinized collagen bundles. We present a patient with SSc who presented with this rare entity.
{"title":"Nodular (keloidal) scleroderma","authors":"Natalia Gabriela Sanchez , Natalia Rebollo Domínguez , Eduwiges Martínez Luna , Pablo Villaseñor Ovies","doi":"10.1016/j.reuma.2023.02.009","DOIUrl":"https://doi.org/10.1016/j.reuma.2023.02.009","url":null,"abstract":"<div><p>Keloidal or nodular scleroderma (NS) is a variant of localized scleroderma (LS) frequently seen in patients with limited or diffuse systemic sclerosis (SSc). It presents as raised, firm plaques or nodules with extensive dermal fibrosis and hyalinized collagen bundles. We present a patient with SSc who presented with this rare entity.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.reuma.2022.07.005
Diego Benavent , Andrea Jochems , Dora Pascual-Salcedo , Gijs Jochems , Chamaida Plasencia-Rodríguez , Sofia Ramiro , Suzanne Arends , Anneke Spoorenberg , Alejandro Balsa , Victoria Navarro-Compán
Background
There is a lack of outcome measures for the assessment of physical activity in patients with axial spondyloarthritis (axSpA). For this matter, the modified Short QUestionnaire to Assess Health (mSQUASH) was developed and validated, originally in Dutch.
Objective
To translate and cross-culturally adapt the mSQUASH into Spanish and to evaluate the equivalence of the translated version in patients with axSpA.
Methods
The mSQUASH was translated following forward-backward procedure according to the protocol of Beaton. Two bi-lingual translators produced independent forward translations of the mSQUASH into Spanish, and the versions were harmonized in a consensual version. Another translator back translated the synthesized version into Dutch. A scientific committee reached consensus on discrepancies and developed a pre-final version of the questionnaire. The field test with cognitive debriefing involved 10 patients with axSpA with different gender, age, disease duration, educational level and working status.
Results
The translation process of the mSQUASH was completed without major issues. The first translation needed several iterations due to small discrepancies in the wording. Back-translation was performed without difficulties, and the scientific committee agreed upon a final version of the questionnaire. Cognitive debriefing showed the Spanish questionnaire to be clear, relevant, understandable and comprehensive. The preliminary version was accepted with minor modifications.
Conclusions
The resulting Spanish version of the mSQUASH showed good linguistic and face validity according to the field test, revealing potential for use in clinical practice and research. In order to conclude the cross-cultural adaptation of the mSQUASH into Spanish, the next step is the assessment of psychometric properties of the Spanish version.
{"title":"Translation and cross-cultural adaptation of the mSQUASH into Spanish","authors":"Diego Benavent , Andrea Jochems , Dora Pascual-Salcedo , Gijs Jochems , Chamaida Plasencia-Rodríguez , Sofia Ramiro , Suzanne Arends , Anneke Spoorenberg , Alejandro Balsa , Victoria Navarro-Compán","doi":"10.1016/j.reuma.2022.07.005","DOIUrl":"10.1016/j.reuma.2022.07.005","url":null,"abstract":"<div><h3>Background</h3><p><span>There is a lack of outcome measures for the assessment of physical activity in patients with </span>axial spondyloarthritis (axSpA). For this matter, the modified Short QUestionnaire to Assess Health (mSQUASH) was developed and validated, originally in Dutch.</p></div><div><h3>Objective</h3><p>To translate and cross-culturally adapt the mSQUASH into Spanish and to evaluate the equivalence of the translated version in patients with axSpA.</p></div><div><h3>Methods</h3><p>The mSQUASH was translated following forward-backward procedure according to the protocol of Beaton. Two bi-lingual translators produced independent forward translations of the mSQUASH into Spanish, and the versions were harmonized in a consensual version. Another translator back translated the synthesized version into Dutch. A scientific committee reached consensus on discrepancies and developed a pre-final version of the questionnaire. The field test with cognitive debriefing involved 10 patients with axSpA with different gender, age, disease duration, educational level and working status.</p></div><div><h3>Results</h3><p>The translation process of the mSQUASH was completed without major issues. The first translation needed several iterations due to small discrepancies in the wording. Back-translation was performed without difficulties, and the scientific committee agreed upon a final version of the questionnaire. Cognitive debriefing showed the Spanish questionnaire to be clear, relevant, understandable and comprehensive. The preliminary version was accepted with minor modifications.</p></div><div><h3>Conclusions</h3><p>The resulting Spanish version of the mSQUASH showed good linguistic and face validity according to the field test, revealing potential for use in clinical practice and research. In order to conclude the cross-cultural adaptation of the mSQUASH into Spanish, the next step is the assessment of psychometric properties of the Spanish version.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43166092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.1016/j.reuma.2023.04.004
Pablo González del Pozo, Stefanie Burger, Estefanía Pardo Campo, Mercedes Alperi López, Rubén Queiro Silva, Sara Alonso Castro
Hajdu-Cheney syndrome or acro-dento-osteo-dysplasia syndrome is a rare disease characterized by band osteolysis of distal phalanges and facial dysmorphia, among other manifestations. We present the case of a 45-year-old male who consulted for mechanical joint pain of both hands, facial dysmorphism, cranio-facial alterations, and digital telescoping with acroosteolysis.
{"title":"Acroosteólisis y dismorfia facial: un nuevo caso de síndrome de Hajdu-Cheney","authors":"Pablo González del Pozo, Stefanie Burger, Estefanía Pardo Campo, Mercedes Alperi López, Rubén Queiro Silva, Sara Alonso Castro","doi":"10.1016/j.reuma.2023.04.004","DOIUrl":"https://doi.org/10.1016/j.reuma.2023.04.004","url":null,"abstract":"<div><p>Hajdu-Cheney syndrome or acro-dento-osteo-dysplasia syndrome is a rare disease characterized by band osteolysis of distal phalanges and facial dysmorphia, among other manifestations. We present the case of a 45-year-old male who consulted for mechanical joint pain of both hands, facial dysmorphism, cranio-facial alterations, and digital telescoping with acroosteolysis.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49864826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-23DOI: 10.1016/j.reuma.2023.08.001
Beatriz Frade-Sosa, Raimon Sanmartí
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by the presence of autoantibodies. Research on the pathogenic mechanisms involved in systemic autoimmune diseases has largely focused on the involvement of the adaptive immune system with dysregulated responses of T and B cells. However, in recent years, there is increasing evidence of the significant role played by the innate immune system, particularly neutrophils, in these diseases, particularly in RA. Neutrophil extracellular traps (NETs) are extracellular structures composed of remodeled and concentrated chromatin with DNA, histones, and neutrophil proteins, and were first described in 2004. It has been studied that NETs may play a pathogenic role in RA and could be a source of autoantigens, increasing the immune response in the form of autoantibodies in this disease. The possible role of NETs and other markers of neutrophil activation as biomarkers of activity in RA and other immune-mediated diseases has also been studied.
This article reviews the role of NETs in RA. It discusses the role of neutrophils and the latest advances in NETs, especially their involvement in autoimmune phenomena in RA. Finally, a literature review is conducted on the determination of NETs in peripheral blood and their relationship as a biomarker of RA activity, as well as their potential role in disease monitoring.
{"title":"Neutrófilos, trampas extracelulares de neutrófilos y artritis reumatoide: una revisión actualizada para clínicos","authors":"Beatriz Frade-Sosa, Raimon Sanmartí","doi":"10.1016/j.reuma.2023.08.001","DOIUrl":"https://doi.org/10.1016/j.reuma.2023.08.001","url":null,"abstract":"<div><p>Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by the presence of autoantibodies. Research on the pathogenic mechanisms involved in systemic autoimmune diseases has largely focused on the involvement of the adaptive immune system with dysregulated responses of T and B cells. However, in recent years, there is increasing evidence of the significant role played by the innate immune system, particularly neutrophils, in these diseases, particularly in RA. Neutrophil extracellular traps (NETs) are extracellular structures composed of remodeled and concentrated chromatin with DNA, histones, and neutrophil proteins, and were first described in 2004. It has been studied that NETs may play a pathogenic role in RA and could be a source of autoantigens, increasing the immune response in the form of autoantibodies in this disease. The possible role of NETs and other markers of neutrophil activation as biomarkers of activity in RA and other immune-mediated diseases has also been studied.</p><p>This article reviews the role of NETs in RA. It discusses the role of neutrophils and the latest advances in NETs, especially their involvement in autoimmune phenomena in RA. Finally, a literature review is conducted on the determination of NETs in peripheral blood and their relationship as a biomarker of RA activity, as well as their potential role in disease monitoring.</p></div>","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49864827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.1016/j.reuma.2023.08.003
Carlos Abud-Mendoza, David Alejandro Herrera vanOostdam
{"title":"Dosis y tiempo de empleo de glucocorticoides en artritis reumatoide","authors":"Carlos Abud-Mendoza, David Alejandro Herrera vanOostdam","doi":"10.1016/j.reuma.2023.08.003","DOIUrl":"https://doi.org/10.1016/j.reuma.2023.08.003","url":null,"abstract":"","PeriodicalId":47115,"journal":{"name":"Reumatologia Clinica","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91984573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}