Industrial Revolution 4.0 is fundamentally changing the economy, the labor market, and the requirements for training professionals. The Concept of Education 4.0 and the Model of the University 4.0 link the requirements of the new industry and the information economy with the development and transformation of education. The study purpose is to identify areas for growth and areas of research excellence in the field of university readiness for the transition of the University 4.0 Model. The study is based on the method of systematic review. The study sample included initially 8389 research articles from the Scopus, World of Science, and Google Scholar databases, from which duplicate sources were filtered and 128 articles relevant to the research area of knowledge were selected. As a result of the algorithmic and human-assisted identification of the main research domains, it was found that the transformation of education toward University 4.0 is actively developing and has reached a peak in terms of the number of publications in 2022; discovery of significant differences in the processes of transformation of university education in different countries and the manifestation of special forms of digital inequality; the crucial role of distance learning and the formation of a digital environment for the transformation toward the University Model 4.0; and the greatest attention to the level of readiness of students and teachers to the processes of transformation of education. The significance and novelty of the study lies in closing the research gap of reviews of this field of research and predicting further research.