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An analysis of different concepts of "identity" in the heritable genome editing debate. 对可遗传基因组编辑辩论中不同 "身份 "概念的分析。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI: 10.1007/s11019-023-10189-1
Ying-Qi Liaw

Human heritable genome editing (HHGE) involves editing the genes of human gametes and/or early human embryos. Whilst 'identity' is a key concept underpinning the current HHGE debate, there is a lack of inclusive analysis on different concepts of 'identity' which renders the overall debate confusing at times. This paper first contributes to reviewing the existing literature by consolidating how 'identity' has been discussed in the HHGE debate. Essentially, the discussion will reveal an ontological and empirical understanding of identity when different types of identity are involved. Here, I discuss genetic, numerical, qualitative and narrative and how each of them is relevant in the HHGE context. Secondly, given the different types of identity, the paper explores how we could navigate these different interpretations of identity in a way that promotes an inclusive and informed discussion between primary stakeholders and the general public in the HHGE debate. Here, I argue for and refine a multi-faceted concept of identity as a suitable framework for discussing the ethical and societal implications of HHGE because it not only could integrate different understandings of identity but also highlight the interconnectedness between these different understandings.

人类可遗传基因组编辑(HHGE)涉及编辑人类配子和/或人类早期胚胎的基因。虽然 "身份 "是当前 HHGE 辩论的一个关键概念,但缺乏对不同 "身份 "概念的包容性分析,这使得整个辩论有时令人困惑。本文首先对现有文献进行了梳理,归纳了在关于 HHGE 的讨论中对 "身份 "的讨论。从本质上讲,讨论将揭示在涉及不同类型身份时对身份的本体论和经验论理解。在此,我将讨论遗传、数字、定性和叙事,以及每种类型如何与高等性别平等问题相关。其次,考虑到身份的不同类型,本文探讨了我们如何以一种促进主要利益相关者和公众在 HHGE 辩论中进行包容和知情讨论的方式来驾驭这些对身份的不同解释。在此,我主张并完善一个多层面的身份概念,将其作为讨论 HHGE 的伦理和社会影响的合适框架,因为它不仅可以整合对身份的不同理解,还可以强调这些不同理解之间的相互联系。
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引用次数: 0
A reply to Gillham on the impairment principle. 对Gillham关于减值原则的答复。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2024-03-01 Epub Date: 2023-10-30 DOI: 10.1007/s11019-023-10180-w
Bruce P Blackshaw

The impairment argument claims that abortion is immoral, because it results in a greater impairment to a fetus than other actions that are clearly immoral, such as inflicting fetal alcohol syndrome. Alex Gillham argues that the argument requires clarification of the meaning of greater impairment. He proposes two definitions, and points out the difficulties with each. In response, I argue that while the impairment argument's definition of greater impairment is narrow in scope, it is sufficient for its intended purpose. Broadening its scope to more controversial comparisons of impairment is likely to undermine the intuitive appeal of the impairment principle that the argument is based upon.

损害论点声称堕胎是不道德的,因为它对胎儿的损害比其他明显不道德的行为更大,比如造成胎儿酒精综合症。Alex Gillham认为,这一论点需要澄清更大损害的含义。他提出了两个定义,并指出了每个定义的难点。作为回应,我认为,虽然减值论点对更大减值的定义范围狭窄,但足以达到其预期目的。将其范围扩大到更有争议的减值比较,可能会破坏该论点所基于的减值原则的直观吸引力。
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引用次数: 0
Potentiality switches and epistemic uncertainty: the Argument from Potential in times of human embryo-like structures. 潜能转换与认识的不确定性:人类胚胎样结构时代的潜能论。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2024-03-01 Epub Date: 2023-10-30 DOI: 10.1007/s11019-023-10181-9
Ana M Pereira Daoud, Wybo J Dondorp, Annelien L Bredenoord, Guido M W R De Wert

Recent advancements in developmental biology enable the creation of embryo-like structures from human stem cells, which we refer to as human embryo-like structures (hELS). These structures provide promising tools to complement-and perhaps ultimately replace-the use of human embryos in clinical and fundamental research. But what if these hELS-when further improved-also have a claim to moral status? What would that imply for their research use? In this paper, we explore these questions in relation to the traditional answer as to why human embryos should be given greater protection than other (non-)human cells: the so-called Argument from Potential (AfP). According to the AfP, human embryos deserve special moral status because they have the unique potential to develop into persons. While some take the development of hELS to challenge the very foundations of the AfP, the ongoing debate suggests that its dismissal would be premature. Since the AfP is a spectrum of views with different moral implications, it does not need to imply that research with human embryos or hELS that (may) have 'active' potential should be completely off-limits. However, the problem with determining active potential in hELS is that this depends on development passing through 'potentiality switches' about the precise coordinates of which we are still in the dark. As long as this epistemic uncertainty persists, extending embryo research regulations to research with specific types of hELS would amount to a form of regulative precaution that as such would require further justification.

发育生物学的最新进展使人类干细胞能够产生胚胎样结构,我们称之为人类胚胎样结构(hELS)。这些结构提供了很有前途的工具,可以补充并可能最终取代人类胚胎在临床和基础研究中的使用。但是,如果这些hELS在进一步改进后也有道德地位的主张呢?这对他们的研究用途意味着什么?在这篇论文中,我们探讨了这些问题,并将其与传统的答案联系起来,即为什么人类胚胎应该比其他(非)人类细胞得到更大的保护:所谓的潜能论证(AfP)。根据AfP的说法,人类胚胎应该享有特殊的道德地位,因为它们具有发育成人的独特潜力。虽然一些人认为hELS的发展挑战了AfP的基础,但正在进行的辩论表明,解雇它为时过早。由于AfP是一系列具有不同道德含义的观点,它不需要意味着对人类胚胎或具有“活跃”潜力的hELS的研究应该完全禁止。然而,在hELS中确定活性电位的问题是,这取决于通过关于精确坐标的“电位开关”的发展,而我们仍然不知道该坐标的精确坐标。只要这种认识上的不确定性持续存在,将胚胎研究法规扩展到特定类型hELS的研究将相当于一种监管预防措施,因此需要进一步的论证。
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引用次数: 0
COVID-19 vaccine refusal as unfair free-riding. COVID-19 疫苗拒绝接种是不公平的搭便车行为。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI: 10.1007/s11019-023-10188-2
Joshua Kelsall

Contributions to COVID-19 vaccination programmes promise valuable collective goods. They can support public and individual health by creating herd immunity and taking the pressure off overwhelmed public health services; support freedom of movement by enabling governments to remove restrictive lockdown policies; and improve economic and social well-being by allowing businesses, schools, and other essential public services to re-open. The vaccinated can contribute to the production of these goods. The unvaccinated, who benefit from, but who do not contribute to these goods can be morally criticised as free-riders. In this paper defends the claim that in the case of COVID-19, the unvaccinated are unfair free-riders. I defend the claim against two objections. First, that they are not unfair free-riders because they lack the subjective attitudes and intentions of free-riders; second, that although the unvaccinated may be free-riders, their free-riding is not unfair.

对 COVID-19 疫苗接种计划的捐助是宝贵的集体财富。疫苗接种计划可以产生群体免疫力,减轻不堪重负的公共卫生服务压力,从而为公众和个人健康提供支持;使政府能够取消限制性封锁政策,从而为行动自由提供支持;使企业、学校和其他基本公共服务机构能够重新开放,从而改善经济和社会福祉。接种疫苗的人可以为这些产品的生产做出贡献。没有接种疫苗的人虽然从这些产品中获益,但却没有为这些产品做出贡献,因此在道德上会被批评为搭便车者。在本文中,我将为 "在 COVID-19 的情况下,未接种者是不公平的搭便车者 "这一主张进行辩护。我针对两种反对意见进行了辩护。第一,他们不是不公平的搭便车者,因为他们缺乏搭便车者的主观态度和意图;第二,尽管未接种疫苗者可能是搭便车者,但他们的搭便车行为并不不公平。
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引用次数: 0
Sharing a medical decision. 分享医疗决定
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2024-03-01 Epub Date: 2023-11-27 DOI: 10.1007/s11019-023-10179-3
Coos Engelsma

During the last decades, shared decision making (SDM) has become a very popular model for the physician-patient relationship. SDM can refer to a process (making a decision in a shared way) and a product (making a shared decision). In the literature, by far most attention is devoted to the process. In this paper, I investigate the product, wondering what is involved by a medical decision being shared. I argue that the degree to which a decision to implement a medical alternative is shared should be determined by taking into account six considerations: (i) how the physician and the patient rank that alternative, (ii) the individual preference scores the physician and the patient (would) assign to that alternative, (iii) the similarity of the preference scores, (iv) the similarity of the rankings, (v) the total concession size, and (vi) the similarity of the concession sizes. I explain why shared medical decisions are valuable, and sketch implications of the analysis for the physician-patient relationship.

在过去的几十年里,共同决策(SDM)已经成为一种非常流行的医患关系模式。SDM可以指过程(以共享的方式做出决策)和产品(做出共享的决策)。在文献中,到目前为止,大多数注意力都集中在这个过程上。在本文中,我调查了该产品,想知道共享医疗决策涉及什么。我认为,实施医疗替代方案的决定在多大程度上是共享的,应该通过考虑六个因素来确定:(I)医生和患者如何对该替代方案进行排名,(ii)医生和患者(将)分配给该替代方案的个人偏好得分,(iii)偏好得分的相似性,(iv)排名的相似性,(v)总让步大小,以及(vi)让步大小的相似性。我解释了为什么共同的医疗决策是有价值的,并概述了分析对医患关系的影响。
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引用次数: 0
A fair exchange: why living kidney donors in England should be financially compensated. 公平交换:英国活体肾脏捐献者应获得经济补偿的原因。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2023-12-01 Epub Date: 2023-08-24 DOI: 10.1007/s11019-023-10171-x
Daniel Rodger, Bonnie Venter

Every year, hundreds of patients in England die whilst waiting for a kidney transplant, and this is evidence that the current system of altruistic-based donation is not sufficient to address the shortage of kidneys available for transplant. To address this problem, we propose a monopsony system whereby kidney donors can opt-in to receive financial compensation, whilst still preserving the right of individuals to donate without receiving any compensation. A monopsony system describes a market structure where there is only one 'buyer'-in this case the National Health Service. By doing so, several hundred lives could be saved each year in England, wait times for a kidney transplant could be significantly reduced, and it would lessen the burden on dialysis services. Furthermore, compensation would help alleviate the common disincentives to living kidney donation, such as its potential associated health and psychological costs, and it would also help to increase awareness of living kidney donation. The proposed system would also result in significant cost savings that could then be redirected towards preventing kidney disease and reducing health disparities. While concerns about exploitation, coercion, and the 'crowding out' of altruistic donors exist, we believe that careful implementation can mitigate these issues. Therefore, we recommend piloting financial compensation for living kidney donors at a transplant centre in England.

每年,英国都有数百名病人在等待肾脏移植期间死亡,这证明现行的利他捐赠制度不足以解决可供移植的肾脏短缺问题。为了解决这一问题,我们提出了一种单利制度,即肾脏捐献者可以选择接受经济补偿,同时仍保留个人在不接受任何补偿的情况下进行捐献的权利。垄断体系是指只有一个 "买方 "的市场结构,在这里指的是国家医疗服务机构。通过这种方式,英国每年可挽救数百人的生命,肾移植的等待时间可大大缩短,并可减轻透析服务的负担。此外,补偿将有助于减轻活体肾脏捐献的常见抑制因素,如潜在的相关健康和心理成本,还将有助于提高人们对活体肾脏捐献的认识。拟议的系统还将节省大量成本,这些成本可转而用于预防肾脏疾病和减少健康差异。虽然存在对剥削、胁迫和 "排挤 "利他主义捐赠者的担忧,但我们相信,精心实施可以减轻这些问题。因此,我们建议在英格兰的一个移植中心试行对活体肾脏捐献者进行经济补偿。
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引用次数: 1
Foucault and medicine: challenging normative claims. 福柯与医学:挑战规范性主张。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2023-12-01 Epub Date: 2023-09-25 DOI: 10.1007/s11019-023-10170-y
Chris A Suijker

Some of Michel Foucault's work focusses on an archeological and genealogical analysis of certain aspects of the medical episteme, such as 'Madness and Civilization' (1964/2001), 'The Birth of the Clinic' (1973) and 'The History of Sexuality' (1978/2020a). These and other Foucauldian works have often been invoked to characterize, but also to normatively interpret mechanisms of the currently existing medical episteme. Writers conclude that processes of patient objectification, power, medicalization, observation and discipline are widespread in various areas where the medical specialty operates and that these aspects have certain normative implications for how our society operates or should operate. The Foucauldian concepts used to describe the medical episteme and the normative statements surrounding these concepts will be critically analyzed in this paper.By using Foucault's work and several of his interpreters, I will focus on the balance between processes of subjectification and objectification and the normative implications of these processes by relating Foucault's work and the work of his interpreters to the current medical discipline. Additionally, by focusing on the discussion of death and biopower, the role of physicians in the negation and stigmatization of death is being discussed, mainly through the concept of biopower. Lastly, based on the discussion of panopticism in the medical discipline, this paper treats negative and positive forms power, and a focus will be laid upon forms of resistance against power. The discussed aspects will hopefully shed a different and critical light on the relationship between Foucault's work and medicine, something that eventually can also be deduced from Foucault's later work itself.

米歇尔·福柯的一些作品侧重于对医学认识论某些方面的考古学和系谱学分析,如《疯狂与文明》(1964/2001)、《诊所的诞生》(1973)和《性史》(1978/2020)。这些和其他傅的著作经常被用来描述,但也被用来规范地解释目前存在的医学认识论的机制。作者得出结论,患者客体化、权力化、医学化、观察和纪律化的过程在医学专业运作的各个领域都很普遍,这些方面对我们的社会如何运作或应该如何运作具有一定的规范意义。本文将批判性地分析用于描述医学认识论的傅尔概念以及围绕这些概念的规范性陈述。通过使用福柯的作品和他的几位口译员,我将通过将福柯的工作和他的口译员的工作与当前的医学学科联系起来,重点关注主体化和客体化过程之间的平衡以及这些过程的规范含义。此外,通过集中讨论死亡和生物权力,主要通过生物权力的概念来讨论医生在否定和污名化死亡中的作用。最后,在对医学学科中的全景主义进行讨论的基础上,本文论述了权力的消极形式和积极形式,并将重点放在对权力的抵抗形式上。所讨论的方面有望对福柯的工作与医学之间的关系提供不同的、批判性的见解,这最终也可以从福柯后来的工作本身中推断出来。
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引用次数: 0
Authenticity and the argument from testability: a bottom-up approach : Author. 真实性与可检验性论证:一种自下而上的方法:作者。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2023-12-01 Epub Date: 2023-08-16 DOI: 10.1007/s11019-023-10166-8
Jasper Debrabander

Jesper Ahlin Marceta published an article in this journal in which he formulated his "argument from testability", stating that it is impossible, at least practically, to operationalize procedural authenticity. That is, using procedural accounts of authenticity, one cannot reliably differentiate between authentic and inauthentic desires. There are roughly two ways to respond to the argument from testability: top-down and bottom-up. Several authors have endeavored the top-down approach by trying to show that some conceptions of authenticity might be operationalizable after all. At present, however, the bottom-up approach has not been put to the test. That is, no attempt has been made to use a currently existing assessment tool to guide the development of an account of authenticity. In this paper, I will investigate what it means to develop an account of authenticity bottom-up based on measures of concordance. More specifically, I will investigate the following three research questions. First, how do concordance and authenticity relate at a conceptual level? As crucial similarities exist between these concepts, concordance measures seem to offer a good starting point for the bottom-up approach. Second, how do judgements of concordance differ from judgements of authenticity? Both their scope and the way they are justified will turn out to be different. This suggests novel ways to react to Marceta's argument from testability. Third, should we develop a theory of concordance? The positive answer to this question will point towards a central limitation of the bottom-up approach.

Jesper Ahlin Marceta 在该杂志上发表了一篇文章,提出了他的 "可检验性论点",指出至少在实践中,程序真实性是不可能操作化的。也就是说,使用程序真实性的说法,人们无法可靠地区分真实和不真实的欲望。对于可检验性的论证,大致有两种回应方式:自上而下和自下而上。一些学者已经尝试了自上而下的方法,试图证明某些真实性概念毕竟是可操作的。然而,目前自下而上的方法还没有得到验证。也就是说,目前还没有人尝试使用现有的评估工具来指导真实性论述的发展。在本文中,我将探究在一致性测量的基础上自下而上地发展真实性论述的意义。更具体地说,我将研究以下三个研究问题。首先,一致性和真实性在概念层面上有什么关系?由于这两个概念之间存在着重要的相似性,一致性测量似乎为自下而上的方法提供了一个良好的起点。其次,对一致性的判断与对真实性的判断有何不同?它们的范围和证明方式都会有所不同。这就提出了对马塞塔的可检验性论证做出反应的新方法。第三,我们是否应该发展一种一致性理论?对这个问题的肯定回答将指出自下而上方法的一个核心局限。
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引用次数: 0
Correction: Editors' statement on the responsible use of generative AI technologies in scholarly journal publishing. 更正:编辑关于在学术期刊出版中负责任地使用人工智能生成技术的声明。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2023-12-01 DOI: 10.1007/s11019-023-10183-7
Gregory E Kaebnick, David Christopher Magnus, Audiey Kao, Mohammad Hosseini, David Resnik, Veljko Dubljević, Christy Rentmeester, Bert Gordijn, Mark J Cherry
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引用次数: 0
Abortion, euthanasia, and the limits of principlism. 堕胎,安乐死,以及原则的极限。
IF 2.1 2区 哲学 Q1 ETHICS Pub Date : 2023-12-01 Epub Date: 2023-07-20 DOI: 10.1007/s11019-023-10162-y
Brieann Rigby, Xavier Symons

Principlism is an ethical framework that has dominated bioethical discourse for the past 50 years. There are differing perspectives on its proper scope and limits. In this article, we consider to what extent principlism provides guidance for the abortion and euthanasia debates. We argue that whilst principlism may be considered a useful framework for structuring bioethical discourse, it does not in itself allow for the resolution of these neuralgic policy discussions. Scholars have attempted to use principlism to analyse the ethics and legality of abortion and euthanasia; but such efforts are methodologically problematic. We close with a consideration of the proper scope of principlism in bioethics-a vision that is more modest than the manner in which principlism is often deployed in contemporary academic bioethics and medical education.

原则主义是一个伦理框架,在过去的50年里一直主导着生物伦理学的论述。对其适当的范围和限制有不同的看法。在本文中,我们考虑原则主义在多大程度上为堕胎和安乐死的辩论提供了指导。我们认为,虽然原则主义可能被认为是构建生物伦理话语的有用框架,但它本身并不允许解决这些神经痛政策讨论。学者们试图用原则主义来分析堕胎和安乐死的伦理性和合法性;但这些努力在方法上存在问题。我们以对生命伦理学中原则的适当范围的考虑作为结束——这一愿景比在当代学术生命伦理学和医学教育中经常采用的原则方式更为温和。
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引用次数: 0
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