Pub Date : 2023-04-25DOI: 10.1177/0143831X231167497
Arūnas Žiedelis, J. Lazauskaitė-Zabielskė, I. Urbanavičiūtė
Although working from home and various other forms of flexible work are often presented as measures to strengthen work–life balance, research depicts a less optimistic picture. Previous research has shown that the impact of telework on work–home conflict is controversial, depending on various factors that are also frequently gender-specific. In this study, the authors evaluate and compare the effects of external expectations (i.e., an organizational overwork climate) and internal expectations (i.e., high personal standards) on changes in work–home conflict between working men and women during the COVID-19 pandemic in Lithuania. Both types of expectations were associated with difficulties reconciling work and private life. Due to their interactions with stereotypical gender roles, organizational expectations encouraging overtime work had a more pronounced effect on male employees. Results suggest that an overwork climate within organizations is a problem not only for employees’ well-being but also poses a risk to gender equality in work and private life.
{"title":"The gendered effect of an overwork climate and high personal standards for work–home conflict during the pandemic","authors":"Arūnas Žiedelis, J. Lazauskaitė-Zabielskė, I. Urbanavičiūtė","doi":"10.1177/0143831X231167497","DOIUrl":"https://doi.org/10.1177/0143831X231167497","url":null,"abstract":"Although working from home and various other forms of flexible work are often presented as measures to strengthen work–life balance, research depicts a less optimistic picture. Previous research has shown that the impact of telework on work–home conflict is controversial, depending on various factors that are also frequently gender-specific. In this study, the authors evaluate and compare the effects of external expectations (i.e., an organizational overwork climate) and internal expectations (i.e., high personal standards) on changes in work–home conflict between working men and women during the COVID-19 pandemic in Lithuania. Both types of expectations were associated with difficulties reconciling work and private life. Due to their interactions with stereotypical gender roles, organizational expectations encouraging overtime work had a more pronounced effect on male employees. Results suggest that an overwork climate within organizations is a problem not only for employees’ well-being but also poses a risk to gender equality in work and private life.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47192608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-23DOI: 10.1177/0143831x231167451
Petr Mezihorak, A. Murgia
By focusing on three groups of whistleblowers in Slovakia speaking out against the use of bogus self-employment in their companies, this study contributes to the debate on the political dimension of whistleblowing. Specifically, it conceptualises whistleblowing as a practice that opens up broader societal, ethical and political questions by examining its relationship to institutions, with particular interest in those institutions that create the law. In doing so, the study analyses how labour law and enforcement institutions are deconstructed through the long process of whistleblowing, which involves the interactions of multiple institutions and social actors in a regulatory space that tend to sustain (bogus) self-employment.
{"title":"From resentment to deconstruction: Whistleblowing as a politico-legal tool of labour law enforcement","authors":"Petr Mezihorak, A. Murgia","doi":"10.1177/0143831x231167451","DOIUrl":"https://doi.org/10.1177/0143831x231167451","url":null,"abstract":"By focusing on three groups of whistleblowers in Slovakia speaking out against the use of bogus self-employment in their companies, this study contributes to the debate on the political dimension of whistleblowing. Specifically, it conceptualises whistleblowing as a practice that opens up broader societal, ethical and political questions by examining its relationship to institutions, with particular interest in those institutions that create the law. In doing so, the study analyses how labour law and enforcement institutions are deconstructed through the long process of whistleblowing, which involves the interactions of multiple institutions and social actors in a regulatory space that tend to sustain (bogus) self-employment.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48333607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.1177/0143831x231161837
Bilal Hassan
This study investigates the political spillover and stealth democracy hypotheses as complementary mechanisms to account for any relationship between workplace democracy and democratic legitimacy in Europe from micro (employee-level) and macro (country-level) perspectives. The results from the micro-level analyses reveal that neither workplace democracy nor self-reported membership in trade unions has any direct impact on democratic legitimacy; rather, past union membership produces a negative impact. However, the effect of workplace democracy on democratic legitimacy becomes salient only when mediated by job satisfaction and political interest. On the other hand, the macro-level analysis demonstrates that union density, a measure of workplace democracy at the country level, plays a significant role in explaining democratic legitimacy. The relevance of union density may indicate that employees wish to keep democratic institutions in check by recruiting into the trade unions and applying legal and mobilizational pressure on the mainstream political institutions.
{"title":"Workplace democracy and democratic legitimacy in Europe","authors":"Bilal Hassan","doi":"10.1177/0143831x231161837","DOIUrl":"https://doi.org/10.1177/0143831x231161837","url":null,"abstract":"This study investigates the political spillover and stealth democracy hypotheses as complementary mechanisms to account for any relationship between workplace democracy and democratic legitimacy in Europe from micro (employee-level) and macro (country-level) perspectives. The results from the micro-level analyses reveal that neither workplace democracy nor self-reported membership in trade unions has any direct impact on democratic legitimacy; rather, past union membership produces a negative impact. However, the effect of workplace democracy on democratic legitimacy becomes salient only when mediated by job satisfaction and political interest. On the other hand, the macro-level analysis demonstrates that union density, a measure of workplace democracy at the country level, plays a significant role in explaining democratic legitimacy. The relevance of union density may indicate that employees wish to keep democratic institutions in check by recruiting into the trade unions and applying legal and mobilizational pressure on the mainstream political institutions.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42817181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.1177/0143831x231161840
Irene Dingeldey, Ilana Nussbaum Bitran
The proposal of a European minimum wage directive by the European Commission was supposed to improve working conditions. This article asks why such an initiative created a challenge to the unity of unions, but not of employers’ associations at transnational level. The authors provide a network analysis of the communication structure of social partners. Applying Scharpf’s concepts of positive and negative integration and Hirschman’s typology of exit, voice and loyalty, the authors use qualitative methods to show how employers stayed loyal and united towards negative integration, while different voices arose within the European Trade Union Confederation (ETUC) leading to the temporary ‘exit’ of the Swedish Trade Union Confederation.
{"title":"The European Minimum Wage Directive – and why it is a challenge to trade unions’ but not employers’ unity","authors":"Irene Dingeldey, Ilana Nussbaum Bitran","doi":"10.1177/0143831x231161840","DOIUrl":"https://doi.org/10.1177/0143831x231161840","url":null,"abstract":"The proposal of a European minimum wage directive by the European Commission was supposed to improve working conditions. This article asks why such an initiative created a challenge to the unity of unions, but not of employers’ associations at transnational level. The authors provide a network analysis of the communication structure of social partners. Applying Scharpf’s concepts of positive and negative integration and Hirschman’s typology of exit, voice and loyalty, the authors use qualitative methods to show how employers stayed loyal and united towards negative integration, while different voices arose within the European Trade Union Confederation (ETUC) leading to the temporary ‘exit’ of the Swedish Trade Union Confederation.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":"1 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42061299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-24DOI: 10.1177/0143831x231160820
Using interview and survey data, in this article the authors compare discrepancies between emic (how union members classify their union participation) and etic (how researchers classify union participation) conceptualizations of union participation. Interview data were used to create activity-level profiles that link how study participants labelled their level of union participation to the union activities they participated in. Survey data were used to determine the relationship between type of participation (i.e. active, passive) and generational cohort to how members view their level of union participation. Qualitative and quantitative findings are compared and implications drawn concerning how researchers/practitioners should conceptualize the union participation construct offered.
{"title":"The union participation construct: A mixed-methods assessment","authors":"","doi":"10.1177/0143831x231160820","DOIUrl":"https://doi.org/10.1177/0143831x231160820","url":null,"abstract":"Using interview and survey data, in this article the authors compare discrepancies between emic (how union members classify their union participation) and etic (how researchers classify union participation) conceptualizations of union participation. Interview data were used to create activity-level profiles that link how study participants labelled their level of union participation to the union activities they participated in. Survey data were used to determine the relationship between type of participation (i.e. active, passive) and generational cohort to how members view their level of union participation. Qualitative and quantitative findings are compared and implications drawn concerning how researchers/practitioners should conceptualize the union participation construct offered.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46540585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-24DOI: 10.1177/0143831x231161839
Seán Ó Riain, A. Healy
The article investigates the emergence of ‘new’ forms of working such as ‘lean production’ and ‘learning organisations’ in Western Europe, 1995–2015. First, the article identifies the dominant forms of work organisation (‘workplace regimes’) across Western Europe, including new ‘pressure’ and ‘extreme’ varieties of previously identified regimes. Second, the article analyses the implications of these workplace regimes for various important worker outcomes – insecurity, income, intensity of work and intrusion of work into non-working life – and assesses the ‘trade-offs’ of different outcomes across regimes. Third, the article assesses the changing distribution of these regimes, whether certain forms such as Lean Production are coming to dominate the division of labour, and where and for whom. The shape of the ‘new world of work’ is increasingly Lean, but remains open to political contestation – both in how regimes themselves are organised and in the mix of regimes in particular societies and for particular workers.
{"title":"Workplace regimes in Western Europe, 1995–2015: Implications for intensification, intrusion, income and insecurity","authors":"Seán Ó Riain, A. Healy","doi":"10.1177/0143831x231161839","DOIUrl":"https://doi.org/10.1177/0143831x231161839","url":null,"abstract":"The article investigates the emergence of ‘new’ forms of working such as ‘lean production’ and ‘learning organisations’ in Western Europe, 1995–2015. First, the article identifies the dominant forms of work organisation (‘workplace regimes’) across Western Europe, including new ‘pressure’ and ‘extreme’ varieties of previously identified regimes. Second, the article analyses the implications of these workplace regimes for various important worker outcomes – insecurity, income, intensity of work and intrusion of work into non-working life – and assesses the ‘trade-offs’ of different outcomes across regimes. Third, the article assesses the changing distribution of these regimes, whether certain forms such as Lean Production are coming to dominate the division of labour, and where and for whom. The shape of the ‘new world of work’ is increasingly Lean, but remains open to political contestation – both in how regimes themselves are organised and in the mix of regimes in particular societies and for particular workers.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47186450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.1177/0143831x231161388
J. M. Kraak, Yannick Griep, Y. Altman
This qualitative research explores the psychological contract (PC) of a sample of self-initiated expatriates (SIEs) working in the French hospitality sector, focusing on PC evaluation as well as reactions to PC breach and feelings of violation. The authors found evidence of a psychological contract type not discussed before in empirical studies. The employer in this research intentionally disrupts the exchange relationship, creating a destructive PC. In these cases, it is assumed that employees would exit such an employment relationship, but instead the study found a mix of dysfunctional behavior in the form of neglect, workplace deviance and revenge cognitions. Accounting for the limitations of the study the authors highlight the implications of the findings for theory, practice and future research.
{"title":"Self-initiated expatriates in menial jobs: Destructive psychological contracts in the hospitality sector","authors":"J. M. Kraak, Yannick Griep, Y. Altman","doi":"10.1177/0143831x231161388","DOIUrl":"https://doi.org/10.1177/0143831x231161388","url":null,"abstract":"This qualitative research explores the psychological contract (PC) of a sample of self-initiated expatriates (SIEs) working in the French hospitality sector, focusing on PC evaluation as well as reactions to PC breach and feelings of violation. The authors found evidence of a psychological contract type not discussed before in empirical studies. The employer in this research intentionally disrupts the exchange relationship, creating a destructive PC. In these cases, it is assumed that employees would exit such an employment relationship, but instead the study found a mix of dysfunctional behavior in the form of neglect, workplace deviance and revenge cognitions. Accounting for the limitations of the study the authors highlight the implications of the findings for theory, practice and future research.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47275622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.1177/0143831x231155975
T. Probst, Jasmina Tomas, L. Roll, Darja Maslić Seršić, Lixin Jiang, Melissa R. Jenkins
Research indicates job insecurity (JI) is related to lower job satisfaction, partially mediated by psychological contract breach (PCB; a perceived breaking of the implicit exchange relationship between employer and employee). The authors investigated the extent to which providing a positive organizational learning climate (OLC) might attenuate the relationships between (a) qualitative JI and PCB and (b) PCB and job satisfaction. Using cross-sectional survey data from higher education industry employees within the US ( N = 372), South Africa ( N = 1096), and Croatia ( N = 719), the study found consistent results across all three settings. Qualitative JI was negatively associated with job satisfaction both directly and indirectly via PCB. Although a positive OLC did not attenuate the relationship between JI and PCB, it did buffer the relationship between PCB and job satisfaction. The findings are discussed in light of Conservation of Resources theory and the need to identify practical organizational interventions to alleviate the adverse effects of qualitative JI.
{"title":"Attenuating the relationship between job insecurity and job satisfaction: An examination of the role of organizational learning climate in three countries","authors":"T. Probst, Jasmina Tomas, L. Roll, Darja Maslić Seršić, Lixin Jiang, Melissa R. Jenkins","doi":"10.1177/0143831x231155975","DOIUrl":"https://doi.org/10.1177/0143831x231155975","url":null,"abstract":"Research indicates job insecurity (JI) is related to lower job satisfaction, partially mediated by psychological contract breach (PCB; a perceived breaking of the implicit exchange relationship between employer and employee). The authors investigated the extent to which providing a positive organizational learning climate (OLC) might attenuate the relationships between (a) qualitative JI and PCB and (b) PCB and job satisfaction. Using cross-sectional survey data from higher education industry employees within the US ( N = 372), South Africa ( N = 1096), and Croatia ( N = 719), the study found consistent results across all three settings. Qualitative JI was negatively associated with job satisfaction both directly and indirectly via PCB. Although a positive OLC did not attenuate the relationship between JI and PCB, it did buffer the relationship between PCB and job satisfaction. The findings are discussed in light of Conservation of Resources theory and the need to identify practical organizational interventions to alleviate the adverse effects of qualitative JI.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44973723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-17DOI: 10.1177/0143831x231157866
D. Alves, A. Duarte, Miriam Rosa, Sílvia da Silva
This study looked into how workers’ perception of their team’s functional indispensability motivates them to engage in promotive voice behavior. The mediating role of psychological ownership and the moderator roles of job insecurity and organizational ambidexterity were also examined. Data from 820 Portuguese workers from different business sectors were analyzed using multiple regression techniques. Results indicate that perceived functional indispensability is positively associated with employee voice behavior, and this relationship is mediated by increased psychological ownership of the organization. Moreover, quantitative job insecurity weakens the link between indispensability and ownership, while ambidexterity reinforces the relationship between indispensability and voice.
{"title":"Do they need us? Linking functional indispensability and voice behavior: The role of psychological ownership, job insecurity and organizational ambidexterity","authors":"D. Alves, A. Duarte, Miriam Rosa, Sílvia da Silva","doi":"10.1177/0143831x231157866","DOIUrl":"https://doi.org/10.1177/0143831x231157866","url":null,"abstract":"This study looked into how workers’ perception of their team’s functional indispensability motivates them to engage in promotive voice behavior. The mediating role of psychological ownership and the moderator roles of job insecurity and organizational ambidexterity were also examined. Data from 820 Portuguese workers from different business sectors were analyzed using multiple regression techniques. Results indicate that perceived functional indispensability is positively associated with employee voice behavior, and this relationship is mediated by increased psychological ownership of the organization. Moreover, quantitative job insecurity weakens the link between indispensability and ownership, while ambidexterity reinforces the relationship between indispensability and voice.","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46514948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01Epub Date: 2022-12-21DOI: 10.1080/10428194.2022.2157676
Diva Baggio, Cameron Wellard, Eliza Chung, Dipti Talaulikar, Colm Keane, Stephen Opat, Pratyush Giri, Adrian Minson, Chan Yoon Cheah, Tasman Armytage, Denise Lee, Geoffrey Chong, Anna Johnston, Tara Cochrane, Neil Waters, Nada Hamad, Erica M Wood, Eliza A Hawkes
Bruton's tyrosine kinase inhibitors (BTKi) have an established role in the management of patients with relapsed/refractory mantle cell lymphoma (MCL). However, scant data exist on outcomes of patients ineligible for clinical trials testing these therapies. We describe a contemporary cohort of relapsed/refractory MCL patients from the Australasian Lymphoma and Related Diseases Registry treated with ibrutinib December 2014 until July 2018, to determine the proportion potentially eligible for original trials, reasons for ineligibility and survival outcomes. Of 44 patients, 41% met one or more exclusion criteria from previous phase II/III MCL BTKi studies. Median progression-free and overall survival were 13.7 months (95% CI 6.2-28.1) and 15.6 months (95% CI 10.8-29.6) respectively and were shorter in patients excluded from clinical trials based on ECOG ≥2. Ibrutinib has demonstrable clinical effectiveness in a population enriched for unfit and trial-ineligible patients, and a need for more inclusive enrollment criteria in future BTKi studies is highlighted.
布鲁顿酪氨酸激酶抑制剂（BTKi）在复发/难治套细胞淋巴瘤（MCL）患者的治疗中发挥着重要作用。然而，关于不符合这些疗法临床试验条件的患者的疗效数据却很少。我们描述了澳大利亚淋巴瘤及相关疾病登记处（Australasian Lymphoma and Related Diseases Registry）2014年12月至2018年7月接受伊布替尼治疗的复发/难治性MCL患者的当代队列，以确定可能符合原始试验条件的比例、不符合条件的原因和生存结果。在44名患者中，41%符合之前II/III期MCL BTKi研究的一项或多项排除标准。无进展生存期和总生存期的中位数分别为13.7个月（95% CI 6.2-28.1）和15.6个月（95% CI 10.8-29.6），因ECOG≥2而被排除在临床试验之外的患者生存期更短。伊布替尼在不适合和不符合试验条件的患者群体中具有明显的临床疗效，因此需要在未来的BTKi研究中采用更具包容性的入组标准。
{"title":"Australian experience with ibrutinib in patients with relapsed/refractory mantle cell lymphoma: a study from the Lymphoma and Related Diseases Registry.","authors":"Diva Baggio, Cameron Wellard, Eliza Chung, Dipti Talaulikar, Colm Keane, Stephen Opat, Pratyush Giri, Adrian Minson, Chan Yoon Cheah, Tasman Armytage, Denise Lee, Geoffrey Chong, Anna Johnston, Tara Cochrane, Neil Waters, Nada Hamad, Erica M Wood, Eliza A Hawkes","doi":"10.1080/10428194.2022.2157676","DOIUrl":"10.1080/10428194.2022.2157676","url":null,"abstract":"<p><p>Bruton's tyrosine kinase inhibitors (BTKi) have an established role in the management of patients with relapsed/refractory mantle cell lymphoma (MCL). However, scant data exist on outcomes of patients ineligible for clinical trials testing these therapies. We describe a contemporary cohort of relapsed/refractory MCL patients from the Australasian Lymphoma and Related Diseases Registry treated with ibrutinib December 2014 until July 2018, to determine the proportion potentially eligible for original trials, reasons for ineligibility and survival outcomes. Of 44 patients, 41% met one or more exclusion criteria from previous phase II/III MCL BTKi studies. Median progression-free and overall survival were 13.7 months (95% CI 6.2-28.1) and 15.6 months (95% CI 10.8-29.6) respectively and were shorter in patients excluded from clinical trials based on ECOG ≥2. Ibrutinib has demonstrable clinical effectiveness in a population enriched for unfit and trial-ineligible patients, and a need for more inclusive enrollment criteria in future BTKi studies is highlighted.</p>","PeriodicalId":47456,"journal":{"name":"Economic and Industrial Democracy","volume":"28 1","pages":"621-627"},"PeriodicalIF":2.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87441355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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