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Demographics and Various Clinical Considerations in Ophthalmic Injuries Associated with Zygomaticomaxillary Complex Fractures: A Retrospective Analysis of 412 Cases in an Indian Population. 颧骨-腋窝复合体骨折相关眼部损伤的人口统计学和各种临床考虑:对印度412例病例的回顾性分析。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-05-16 DOI: 10.1007/s12663-025-02550-z
Sreea Roy, G Srikanth, A Chithra, Adarsh Kudva, Sunil Nayak, Anand Deep Shukla, Sudha Menon, Surbhi Varshney

Introduction: The ZMC complex is crucial for orbital integrity as it forms most of the lateral wall and the floor of the orbit. Therefore, the fracture of the zygomaticomaxillary complex destroys the orbital skeleton causing various types of ophthalmic injuries in about 2.7 to 96% of cases. The variability of clinical features is due to differences in the amount of energy delivered, the impact vector, and the duration of the impact of energy.

Aim: To study the demographic distribution and clinical manifestation of different types of ophthalmic injuries in patients associated with ZMC fractures and to understand the need for evaluation by an ophthalmologist.

Objectives: To study the common fracture patterns, sex and age demographics, and etiology of ZMC fractures. To study the presence of various types of clinical manifestation in ZMC fractures.

Materials & methods: A retrospective study was conducted by the Manipal College of Dental Sciences, Manipal, Karnataka, India, by the Department of Oral and Maxillofacial Surgery studying ophthalmic consideration and clinical manifestation of patients having zygomaticomaxillary complex fracture from February 2019 to December 2022. Data collection was done from patient files and subjected to descriptive statistics.

Results: It was found that the affected population is mainly Indian males in the second decade of their life mostly due to road traffic accidents. A variety of ophthalmic injuries was noted. Periorbital oedema and ecchymosis are the most common ones.

ZMC复合体对轨道完整性至关重要,因为它形成了轨道的大部分侧壁和底。因此,约2.7 ~ 96%的病例中,颧腋复合体骨折破坏眶骨,造成不同类型的眼部损伤。临床特征的可变性是由于能量传递量、冲击矢量和能量冲击持续时间的差异。目的:研究ZMC骨折患者不同类型眼损伤的人口分布及临床表现,了解眼科医师评估的必要性。目的:探讨ZMC骨折的常见骨折类型、性别、年龄特征及病因。目的:探讨ZMC骨折的不同类型临床表现。材料与方法:回顾性研究2019年2月至2022年12月印度卡纳塔克邦马尼帕尔马尼帕尔口腔科学学院口腔颌面外科对颧骨-腋窝复合骨折患者的眼科考虑和临床表现进行研究。从患者档案中收集数据并进行描述性统计。结果:受影响人群以印度男性为主,年龄在20岁以上,主要受道路交通事故影响。观察到多种眼部损伤。眶周水肿和瘀斑是最常见的。
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引用次数: 0
The Effect of Kinesio Taping After Impacted Third Molar Surgery: A Randomized Control Trial. 第三磨牙阻生手术后肌内效贴贴的效果:一项随机对照试验。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-02-18 DOI: 10.1007/s12663-025-02487-3
Shradhaa Narayan, Chaitra Patil, Ramdas Balakrishna, Vinayaka T Banakar

Objective: To examine the effect of Kinesio taping on postoperative trismus, and soft tissue oedema and pain after surgical removal of impacted mandibular third molars.

Materials and methods: Forty patients with impacted mandibular third molars who required surgical extraction were randomly selected and allotted into two groups, a control and a study, and the patients in the study group were applied Kinesio Tape 2m*5m for 3 days postoperatively. In both groups, pain, trismus, and swelling preoperatively and postoperatively on day 3 and day 7 were measured. Facial swelling was measured using a flexible scale, using a five-point measurement, trismus using Vernier callipers, and pain using visual analogue scale.

Results: Forty patients were followed up for 7 days, and swelling, pain, and trismus were measured. Results showed significant improvement in trismus and swelling on postoperative day 3 and 7 in the study group.

Conclusion: The application of Kinesio tape is a non-invasive, easy economical, and medically relevant approach.

目的:探讨肌内效贴对下颌阻生第三磨牙拔除术后牙关紧闭、软组织水肿及疼痛的影响。材料与方法:随机选择40例需要手术拔牙的下颌阻生第三磨牙患者,分为对照组和研究组,实验组患者术后应用2米*5米的肌内效贴贴3天。两组患者术前、术后第3天、第7天分别测量疼痛、牙关、肿胀情况。面部肿胀采用弹性量表,采用五点测量法,牙牙咬合采用游标卡尺,疼痛采用视觉模拟量表。结果:40例患者随访7 d,测量肿胀、疼痛、牙关。结果显示研究组术后第3天和第7天牙关和肿胀明显改善。结论:肌内效贴是一种无创、简便、经济、符合医学要求的方法。
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引用次数: 0
The Distance from the Coronoid Notch to the Mandibular Lingula: Is This a Safe Reference Point for Bilateral Sagittal Split Osteotomy? 冠状切口到下颌舌骨的距离:这是双侧矢状面劈开截骨的安全参考点吗?
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-02-05 DOI: 10.1007/s12663-025-02460-0
Fahad S Al Qooz, Mohammad S Al Olaimat, Zaid R Alzoubi, Mohammed A Alkhawaldeh, Luma A Al Najada

Introduction: Sagittal split osteotomy is a standard procedure performed by maxillofacial surgeons. Patients usually present with either aesthetic or functional concerns. Surgical landmark identification is crucial to a successful surgical procedure. Various diagnostic preoperative tools have been used to identify these landmarks, such as imaging studies or cadaveric dissections. The cone-beam computed tomography (CBCT) is currently the most common preoperative tool used.

Aim: This study aims to identify whether the deepest part of the ascending ramus (coronoid notch) distance to the mandibular lingula can be used as a safe reference prior to performing medial horizontal osteotomies.

Materials & methods: Data were extracted from a database of patients who underwent CBCT scanning for various reasons. A total of 313 CBCT scans were included in this study. Patients younger than 18 years, with a history of mandibular pathology, or whose scans were suboptimal were excluded. Statistical analysis was performed via IBM SPSS v29 (IBM Corp., Armonk, NY, U.S.), and the predetermined p-value was < 0.05. Statistical significance was present in both the right and left measurements.

Results: A total of 313 (626 sides) CBCT were included in this study. Most patients were of the female gender, with 171 scans (54.6%) and 142 scans (45.4%) from males. Our study focused on the distance from the specific reference point, the coronoid notch (the most concave point at the ascending ramus in the retromolar area), to the anterior part of the mandibular lingula. For the total sample, the standard deviations for each side were 2.25 (p-value = < 0.001) and 2.07 (p-value = 0.003), left and right, respectively. This finding indicated that the distances on each side were statistically significant.

Conclusion: The authors suggest that the anterior aspect of the ramus can be used as a reference point for horizontal medial osteotomy, as both distances were statistically significant. This finding has important implications for the safety and efficiency of bilateral sagittal split osteotomy procedures, as it provides a reliable reference point for surgeons to use during the procedure, potentially reducing the risk of complications, surgical time, and improving patient outcomes.

矢状面劈开截骨术是颌面外科的标准手术。患者通常表现为审美或功能方面的问题。手术标志的识别是外科手术成功的关键。各种诊断术前工具已被用于识别这些标志,如成像研究或尸体解剖。锥束计算机断层扫描(CBCT)是目前最常用的术前工具。目的:本研究旨在确定升支最深部分(冠状切迹)到下颌舌的距离是否可以作为进行内侧水平截骨术之前的安全参考。材料与方法:数据取自因各种原因接受CBCT扫描的患者数据库。本研究共纳入313份CBCT扫描。年龄小于18岁、有下颌骨病理史或扫描结果不理想的患者排除在外。采用IBM SPSS v29 (IBM Corp., Armonk, NY, U.S.)进行统计分析,预定p值为。结果:本研究共纳入313张(626侧)CBCT。多数患者为女性,男性171例(54.6%),142例(45.4%)。我们的研究重点是从特定的参考点冠状切迹(臼齿后区升支最凹的点)到下颌舌前部的距离。对于总样本,左右两侧的标准差分别为2.25 (p-value = p-value = 0.003)。这一发现表明,两边的距离在统计学上是显著的。结论:作者认为分支的前部可以作为水平内侧截骨的参考点,因为这两个距离具有统计学意义。这一发现对双侧矢状面劈开截骨术的安全性和有效性具有重要意义,因为它为外科医生在手术过程中使用提供了可靠的参考点,有可能减少并发症的风险,缩短手术时间,改善患者的预后。
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引用次数: 0
Guided Bone Regeneration (GBR) Using a Collagen Membrane Barrier Technique Along With Full Thickness Buccal Mucoperiosteal Flap For the Preservation of the Alveolar Ridge Following Tooth Extraction. 应用胶原膜屏障技术及全厚颊粘膜骨膜瓣在牙槽嵴修复中的应用。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-02-13 DOI: 10.1007/s12663-024-02419-7
P K Rabha, Subhas Chandra Debnath, Anovili N Chishi, Priyangana Nath, A Dhanushya

Introduction: The preservation of the alveolar ridge following tooth extraction is important for maintaining optimal dental health and ensuring successful future dental interventions. Various techniques for alveolar ridge preservation are done, including socket grafting and the use of biomaterials, membranes, and growth factors, which have a plenty of clinical benefits, such as improved aesthetics and stability for dental implants along with potential cost-effectiveness compared to more invasive procedures, thus optimizing treatment outcomes and promoting long-term dental health.

Aim: To assess the effectiveness of bone graft material and collagen membrane for ridge preservation following tooth extraction compared to tooth extraction alone group.

Materials and method: Ninety patients presenting with the need for extraction were included in this study.They were divided into three groups. In group A, the socket was filled with bone allograft and protected with a fish derived collagen membrane without buccal thickness flap. In group B, buccal/labial thickness flap was elevated, socket was filled with bone allograft and protected with a fish derived collagen membrane barrier, and in group C, no bone graft and collagen membranes were placed.

Results: Showed that group A is much more beneficial and simpler than the group B procedures.

Conclusion: Bone regeneration using collagen membranes and inorganic bovine bone combination seems promising. But, there is obviously a need for long-term studies to confirm the success rate of ridge preservation procedures using buccal full thickness flap and without buccal full thickness flap.

摘牙后牙槽嵴的保存对于维持最佳牙齿健康和确保未来牙科干预的成功是重要的。牙槽嵴保存的各种技术,包括牙槽骨移植和生物材料、膜和生长因子的使用,这些技术具有许多临床益处,例如与更具侵入性的手术相比,牙种植体的美观性和稳定性得到改善,同时具有潜在的成本效益,从而优化治疗结果并促进长期牙齿健康。目的:对比单纯拔牙组和植骨材料联合胶原膜对拔牙后牙脊的保护效果。材料和方法:本研究纳入了90例有拔牙需求的患者。他们被分成三组。A组用同种异体骨填充牙槽,用鱼源性胶原膜保护牙槽,不带颊厚瓣。B组提升颊/唇厚瓣,用同种异体骨移植物填充牙槽,并用鱼源性胶原膜屏障保护牙槽;C组不放置骨移植物和胶原膜。结果:A组手术效果好,操作简便。结论:胶原膜与无机牛骨结合再生骨具有良好的应用前景。但是,显然需要长期的研究来证实使用颊全层皮瓣和不使用颊全层皮瓣的脊保留手术的成功率。
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引用次数: 0
Lateral Orbital Rim Access Osteotomy and Cryo-Assisted Approach for Surgical Management of Orbital Schwannoma: A Case Report. 外侧眶缘入路截骨和冷冻辅助入路治疗眼眶神经鞘瘤1例报告。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2024-12-16 DOI: 10.1007/s12663-024-02414-y
Srivalli Natarajan, Himika Gupta, Abhishek Das, Ruchita Balkawade, Padmakar Baviskar

A schwannoma is a benign, slow-growing peripheral nerve sheath tumour that originates from Schwann cells. Orbital schwannomas are rare, accounting for only 1% of all orbital neoplasms. Preoperative diagnosis of schwannoma is difficult because of its variable presentation and location. Appropriate early assessment of orbital tumours by CT or MRI and prompt management is warranted to prevent the development of severe complications. Authors would like to present here one such case of orbital schwannoma and management of the same.

神经鞘瘤是一种良性、生长缓慢的周围神经鞘肿瘤,起源于雪旺细胞。眼眶神经鞘瘤很少见,仅占所有眼眶肿瘤的1%。术前诊断神经鞘瘤是困难的,因为它的变化的表现和位置。通过CT或MRI对眼眶肿瘤进行适当的早期评估并及时处理是必要的,以防止严重并发症的发生。作者在此报告一例眶神经鞘瘤及其治疗。
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引用次数: 0
Mandibular Squamous Cell Carcinoma Mimicking Chronic Osteomyelitis: Diagnostic Dilemma. 模拟慢性骨髓炎的下颌鳞状细胞癌:诊断困境。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-02-07 DOI: 10.1007/s12663-025-02450-2
Rajarshi Ghosh, Namrata Sinha, Sajid Ansari, Srinjeeta Garg, Rajesh Kumar Gupta, Mitali Dandekar
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引用次数: 0
Application of Flexor Hallucis Longus Muscle in Mandibular Reconstruction for Hardware Coverage in Postoperative Radiotherapy. 拇长屈肌在下颌骨重建中的应用。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-04-22 DOI: 10.1007/s12663-025-02532-1
Sushree Mahapatra, Pranav Thusay, Pushkar P Waknis, Unnati B Mehta

Background: Mandibular reconstruction after head and neck cancer surgery is mostly a complex procedure, especially when followed by radiotherapy. Although the fibular free flap remains a reliable option, radiotherapy can compromise soft tissue healing, increasing the risk of hardware exposure and osteoradionecrosis.

Purpose: This technical note explores the use of the flexor hallucis longus (FHL) muscle in mandibular reconstruction, specifically for improving soft tissue coverage over reconstruction plates and minimizing radiation-related complications.

Methods: The FHL muscle was harvested alongside the fibular flap and was positioned over the reconstruction plate to provide a vascularized, durable layer of soft tissue. Its strong blood supply from the posterior tibial artery, combined with its bulk and resilience, was intended to offer better protection and healing in patients undergoing postoperative radiotherapy.

Results: Clinical experience showed that the FHL muscle helped reduce the risk of plate exposure and radiation-induced damage. Its vascularity not only promoted healing, while its bulk acted as a cushion against shear forces and tissue breakdown, but also this muscle also contributed to maintaining tissue integrity and minimizing the risk of osteoradionecrosis, with no significant increase in donor site morbidity.

Conclusion: Incorporating the FHL muscle in fibular flap-based mandibular reconstruction adds meaningful protection for patients receiving radiotherapy. It supports healing, safeguards underlying hardware, and improves both functional and aesthetic outcomes.

背景:头颈癌手术后下颌骨重建是一个复杂的过程,尤其是放疗后。虽然腓骨游离皮瓣仍然是一个可靠的选择,但放射治疗会损害软组织愈合,增加硬件暴露和骨放射性坏死的风险。目的:本技术报告探讨了拇长屈肌(FHL)在下颌骨重建中的应用,特别是用于改善重建板上的软组织覆盖范围,并最大限度地减少辐射相关并发症。方法:沿腓骨瓣采集FHL肌肉,并将其置于重建板之上,以提供一层血管化的、持久的软组织。其来自胫骨后动脉的强大血液供应,结合其体积和弹性,旨在为术后放疗患者提供更好的保护和愈合。结果:临床经验表明,FHL肌有助于降低钢板暴露和辐射损伤的风险。它的血管性不仅促进愈合,同时它的体积起到缓冲剪切力和组织破裂的作用,而且这种肌肉也有助于保持组织完整性和最大限度地减少骨放射性坏死的风险,没有显著增加供体部位的发病率。结论:应用FHL肌进行腓骨瓣下颌骨重建对放疗患者有一定的保护作用。它支持修复,保护底层硬件,并改善功能和美观结果。
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引用次数: 0
Assessing Complications and Outcomes of Pectoralis Major Myocutaneous Flap in Head and Neck Oncology: Insights from 150 Cases. 150例胸大肌肌皮瓣在头颈部肿瘤治疗中的并发症及预后评价。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2024-10-25 DOI: 10.1007/s12663-024-02359-2
Agil Babu, Suresh Singh, Kamal Kishor Lakhera, Pinakin Patel, Aishwarya Chatterjee, Pranav Mohan Singhal, Naina Kumar, Rajat Choudhari, Yashasvi Patel

Background: Reconstruction after tumor removal in the head and neck region presents a challenge for balancing functionality and aesthetics. The pectoralis major myocutaneous flap (PMMC) is a reliable option for post-tumor resection reconstruction. However, complications such as flap necrosis, detachment, donor site tumor recurrence, wound infections, and wound dehiscence have been encountered in 150 cases where PMMC was utilized. This retrospective study focuses on analyzing the complications and experiences associated with using PMMC in head and neck oncology.

Materials and methods: This analysis looks back at 150 cases of head and neck oncology that underwent PMMC flap reconstruction. Of these cases, 128 (85.3%) involved buccal mucosa reconstruction, while 22 (14.7%) focused on the tongue, floor of the mouth, and neck. Out of the total 150 cases, 141 cases (94%) were male, and 9 cases (6%) were female. We carefully documented any complications, paying specific attention to flap necrosis, detachment, donor site tumor recurrence, flap retraction, oro-cutaneous fistula, wound infections, and wound dehiscence.

Results: The study result concluded following complications were encountered, and there were instances of flap necrosis observed in 9 cases (6%). Additionally, 16 cases (10.7%) experienced flap detachment, which impacted postoperative recovery and necessitated further interventions, and 11 cases (7.3%) had flap retraction. Three cases (2%) exhibited tumor recurrence at the donor site following PMMC flap harvesting. Wound infections were prevalent, affecting 13 patients (8.6%). Two patients (1.3%) experienced donor site wound dehiscence postoperatively, and five patients (3.3%) had oro-cutaneous fistula.

Conclusion: The use of PMMC flaps in head and neck oncology requires careful consideration, surgical expertise, and postoperative care to minimize complications. Although it has been historically significant and useful, advanced surgical techniques and postoperative care protocols are necessary to optimize outcomes in PMMC flap reconstructions. Therefore, meticulous patient selection and vigilant postoperative care are essential for addressing and minimizing complications.

背景:头颈部肿瘤切除后的重建对平衡功能和美观提出了挑战。胸大肌肌皮瓣(PMMC)是肿瘤切除后重建的可靠选择。然而,在150例应用PMMC的病例中,出现了皮瓣坏死、脱离、供区肿瘤复发、创面感染、创面裂开等并发症。本回顾性研究的重点是分析在头颈部肿瘤中使用PMMC的并发症和经验。材料与方法:回顾分析150例头颈部肿瘤患者行PMMC皮瓣重建的病例。其中128例(85.3%)涉及颊黏膜重建,22例(14.7%)集中在舌、口底和颈部。150例中,男性141例(94%),女性9例(6%)。我们仔细记录了任何并发症,特别注意皮瓣坏死、脱离、供区肿瘤复发、皮瓣缩回、口-皮瘘、伤口感染和伤口开裂。结果:本研究共发生以下并发症,其中皮瓣坏死9例(6%)。此外,16例(10.7%)发生皮瓣脱离,影响术后恢复,需要进一步干预,11例(7.3%)发生皮瓣缩回。3例(2%)在PMMC皮瓣切除后出现供区肿瘤复发。伤口感染普遍存在,13例(8.6%)。术后供区创面裂开2例(1.3%),口皮瘘5例(3.3%)。结论:在头颈部肿瘤中使用PMMC皮瓣需要仔细考虑,外科专业知识和术后护理,以尽量减少并发症。虽然具有重要的历史意义和实用性,但先进的手术技术和术后护理方案对于优化PMMC皮瓣重建的结果是必要的。因此,细致的患者选择和警惕的术后护理是解决和减少并发症的必要条件。
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引用次数: 0
A Rare Presentation of Cemento-ossifying Fibroma with Inherent High Flow Vascular Malformation: A Wolf in Sheep's Clothing. 一例罕见的骨水泥骨化纤维瘤伴固有高流量血管畸形:一只披着羊皮的狼。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-02-05 DOI: 10.1007/s12663-025-02466-8
Murtaza Ali, Arjun Mahajan, Vyomika Bansal, Akhilesh Kumar Singh

Background: Cemento-ossifying fibroma (COF) is a rare subtype of benign fibro-osseous lesions predominantly affecting the craniofacial region. But tumor with combination of COF and vascular malformation has not been described in literature.

Case: Following is the case of 14-year-old female patient with extensive COF of right maxilla encroaching orbit, maxillary antrum, nasal cavity, and zygoma. During course of careful investigations, embedded vascular malformation based on right maxillary and facial artery was diagnosed, in which aspiration cytology played crucial role. After confirmation by computed tomographic (CT) angiography, proper vascular control was gained by superselective embolization followed by surgical resection as definitive management.

背景:骨水泥骨化纤维瘤(COF)是一种罕见的良性纤维骨性病变亚型,主要影响颅面区域。但合并COF和血管畸形的肿瘤尚未见文献报道。病例:14岁女性,右上颌广泛COF侵犯眶、上颌窦、鼻腔及颧骨。在仔细的检查过程中,诊断出基于右上颌和面动脉的嵌入性血管畸形,其中吸痰细胞学检查起了关键作用。经计算机断层扫描(CT)血管造影确认后,通过超选择性栓塞获得适当的血管控制,然后手术切除作为最终管理。
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引用次数: 0
Comparative Evaluation of Upfront Surgery and Neoadjuvant Chemotherapy Followed by Surgery in Locally Advanced Oral Squamous Cell Carcinoma. 局部晚期口腔鳞状细胞癌术前与术后新辅助化疗的比较评价。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-05-03 DOI: 10.1007/s12663-025-02549-6
Rathindra Nath Bera, Richik Tripathi, Ritusha Mishra

Introduction: Oral squamous cell carcinoma with stage T3 and above constitutes locally advanced disease without distant metastasis. Even with multimodality treatment, the 5-year survival is less than 50%. In this retrospective study, we shared our experience from a single center of the utility of neoadjuvant chemotherapy in the outcome of cT4 oral cavity squamous cell carcinoma.

Methods: Patients who underwent surgery either in the form of upfront resection or induction chemotherapy followed by surgery were considered for evaluation. Patients in the induction group underwent three cycles of NACT prior to response assessment. Patients with complete response underwent surgery, and partial responders were given fourth cycle of NACT prior to surgery. Patients with stable disease or disease progression were subjected to nonsurgical therapy. The primary endpoint assessment of the study was overall survival and disease-free survival. Secondary outcomes assessed were the extent of resectability after NACT, frequency of marginal mandibulectomies, postoperative radiotherapy and response following NACT.

Results: A total of 285 patients were initially screened for the review; of which 164 patients (Group A) underwent upfront surgical resection and 121 patients received NACT. The median DFS and OS in our study were 28 months and 30 months, respectively. There was no difference in DFS and OS between upfront surgery and NACT surgery. On subset analysis, NACT improved survival only in T4b patients. Positive margin, nodal metastasis and presence of extracapsular spread were the risk factors effecting survival.

Discussion: Induction chemotherapy improved survival only in T4b patients. There was no difference in survival in T4a patients with the addition of NACT. Overall no difference was seen in survival with the use of induction chemotherapy.

口腔鳞癌T3期及以上为局部晚期,无远处转移。即使采用多模式治疗,5年生存率仍低于50%。在这项回顾性研究中,我们分享了我们在cT4口腔鳞状细胞癌预后中新辅助化疗的应用经验。方法:对术前切除或术后诱导化疗的患者进行评估。诱导组患者在反应评估前进行了三个周期的NACT治疗。完全缓解的患者接受手术,部分缓解的患者在手术前给予第四个周期的NACT治疗。病情稳定或病情进展的患者接受非手术治疗。该研究的主要终点评估是总生存期和无病生存期。评估的次要结果是NACT后可切除的程度,下颌边缘切除术的频率,术后放疗和NACT后的反应。结果:共有285名患者被筛选入组;其中A组164例患者行前期手术切除,121例患者行NACT。我们研究的中位DFS和OS分别为28个月和30个月。前期手术与NACT手术的DFS和OS无差异。在亚群分析中,NACT仅改善了T4b患者的生存。切缘阳性、淋巴结转移和囊外扩散是影响生存的危险因素。讨论:诱导化疗仅改善T4b患者的生存。T4a患者加入NACT后生存率无差异。总的来说,诱导化疗在生存率方面没有差异。
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引用次数: 0
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Journal of Maxillofacial & Oral Surgery
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